阅读说明：本技术 挤压瓶 (Squeeze bottle ) 是由 池田直浩 固城浩幸 于 2018-04-13 设计创作，主要内容包括：本发明涉及一种挤压瓶,其一体化地具备：含有用于收容液状组合物的收容部及与所述收容部连接设置的倒出口的容器主体、以及以密封所述倒出口的开口部的方式与所述容器主体接合的盖,所述容器主体包含含有环状烯烃类及聚乙烯类的树脂。(The present invention relates to a kind of squeeze bottles, it integrally has: connect containing the receiving portion for accommodating liquid composition and with the receiving portion pouring spout of setting container body and the opening portion to seal the pouring spout in a manner of the lid that is engaged with the container body, the container body includes the resin containing cyclic olefin and polyethylene kind.)

1. a kind of squeeze bottle, integrally has: containing for accommodating liquid composition receiving portion and with the receiving portion It is connect in a manner of the container body of the pouring spout of connection setting and the opening portion to seal the pouring spout with the container body The lid of conjunction,

The container body includes the resin containing cyclic olefin and polyethylene kind.

2. squeeze bottle according to claim 1, wherein the area of the opening portion of the pouring spout is 0.15~20.0mm²。

3. squeeze bottle according to claim 1 or 2, wherein the compressive strength of the side of the receiving portion is 20~250N/ mm。

4. squeeze bottle described in any one of claim 1 to 3, wherein the container body is in 400~700nm of wavelength Visible light region in light transmittance maximum value be 50% or more.

5. squeeze bottle according to any one of claims 1 to 4, wherein the container body is by containing internal layer and outer layer 2 or more layers constitute, the internal layer to connect with the liquid composition include contain cyclic olefin and polyethylene kind Resin.

6. squeeze bottle according to any one of claims 1 to 5, wherein the polyethylene kind be low density polyethylene (LDPE) and/ Or linear low density polyethylene.

7. squeeze bottle described according to claim 1~any one of 6, wherein to contain the cyclic olefin and polyethylene On the basis of the total amount of the resin of class, in the resin layer containing cyclic olefin and polyethylene kind that connects with the liquid composition The cyclic olefin total content be 50~99 mass %.

8. squeeze bottle according to any one of claims 1 to 7, wherein the liquid composition is ophthalmic composition.

Technical field

The present invention relates to a kind of squeeze bottles.

Background technique

As the container of receiving aqueous pharmaceutical preparations, For example, Patent Document 1 discloses a kind of plastic ampoule bottles, lead to Cross blowing encapsulating (BFS) method and being integrally melted into for the filling of the molding, aqueous pharmaceutical preparation that are carried out continuously container and the sealing of container Type forms.

Summary of the invention

The technical problem to be solved in the present invention

On the other hand, in the squeeze bottle of the liquid compositions such as ophthalmic of the receiving containing drug, it is being added dropwise or is pouring out liquid When shape composition, it is desirable that drop easy to form certainly can be added dropwise or be poured on the parts such as eyes or contact lenses and energy Enough good operability for steadily controlling dripping quantity or flow capacity.

The purpose of the present invention is to provide a kind of for accommodating the squeeze bottle of liquid composition, which is integrated chemical conversion Squeeze bottle made of type, the operability when being added dropwise or pouring out are excellent.

Solve the technological means of technical problem

Present inventor is it was unexpectedly observed that carry out integration using the resin containing cyclic olefin and polyethylene kind Operability of the squeeze bottle being molded with when being added dropwise or pouring out is excellent.

The present invention is based on above-mentioned opinions to form, and provides each invention below.

[1] a kind of squeeze bottle, integrally has: containing for accommodating liquid composition receiving portion and with the receipts Appearance portion connection setting pouring spout container body and the opening portion to seal the pouring spout in a manner of with the container master The lid of body engagement,

The container body includes the resin containing cyclic olefin and polyethylene kind.

[2] squeeze bottle according to [1], wherein the area of the opening portion of the pouring spout is 0.15~20.0mm²。

[3] squeeze bottle according to [1] or [2], wherein the compressive strength of the side of the receiving portion be 20~ 250N/mm。

[4] squeeze bottle according to any one of [1]~[3], wherein the container body is in 400~700nm of wavelength Visible light region in light transmittance maximum value be 50% or more.

[5] squeeze bottle according to any one of [1]~[4], wherein the container body is by containing internal layer and outer layer 2 or more layers constitute, the internal layer to connect with the liquid composition include contain cyclic olefin and polyethylene kind Resin.

[6] squeeze bottle according to any one of [1]~[5], wherein the polyethylene kind is low density polyethylene (LDPE) And/or linear low density polyethylene.

[7] squeeze bottle according to any one of [1]~[6], wherein to contain the cyclic olefin and polyethylene On the basis of the total amount of the resin of class, in the resin layer containing cyclic olefin and polyethylene kind that connects with the liquid composition The cyclic olefin total content be 50~99 mass %.

[8] squeeze bottle according to any one of [1]~[7], wherein the liquid composition is ophthalmic combination Object.

[9] a kind of manufacturing method of squeeze bottle comprising: it is carried out using containing the resin of cyclic olefin and polyethylene kind Integrated molding.

[10] a kind of method for the operability for improving the liquid composition that discharge is housed in squeeze bottle comprising: pass through Integrated molding is carried out using the resin containing cyclic olefin and polyethylene kind, manufactures squeeze bottle.

Invention effect

In accordance with the invention it is possible to provide a kind of for accommodating the squeeze bottle of liquid composition, it is molded with for integration Squeeze bottle, when being added dropwise or pouring out operability it is excellent.

Detailed description of the invention

(a) of Fig. 1 is the main view for indicating the structure of squeeze bottle of an embodiment of the invention,

(b) of Fig. 1 is the left view for indicating the structure of the squeeze bottle of an embodiment of invention.

Fig. 2 is the main view for indicating structure made of connecting the squeeze bottle of multiple an embodiment of the invention.

Fig. 3 is the perspective view for indicating the method for measurement maximum test force.

(a) of Fig. 4 is the main view for indicating the structure of manufactured squeeze bottle in test example 4, and (b) of Fig. 4 is to indicate The left view of the structure of manufactured squeeze bottle in test example 4, (c) of Fig. 4 are to be shown schematically in manufactured in test example 4 squeeze The figure in the section (along the section in the direction vertical with the direction for being added dropwise or pouring out liquid composition) of the receiving portion of pressure bottle.

Fig. 5 is the main view for indicating the squeeze bottle of manufactured multiple connection status in test example 4.

Specific embodiment

Hereinafter, mode for carrying out the present invention is described in detail.But the present invention is not by embodiment party below Formula limits.

(a) of Fig. 1 is the main view for indicating the structure of squeeze bottle of an embodiment of the invention, and (b) of Fig. 1 is table Show the left view of the structure of the squeeze bottle of an embodiment of invention.As Fig. 1 (a) and (b) shown in, the integration of squeeze bottle 1 Ground has: the container body of the pouring spout 4 of setting is connect comprising the receiving portion 3 for accommodating liquid composition and with receiving portion 3 2, the lid 6 engaged in a manner of the opening portion 5 for sealing pouring spout 4 with container body 2.In addition, the squeeze bottle of present embodiment can Further integrally have the opening portion 5 of connection pouring spout 4 and the thinner wall section of lid 6.In above structure, received by grip Appearance portion 3 and lid 6, twist pull apart mutually, round about thus the opening portion 5 for pouring spout 4 of breaking seal.

Fig. 2 is the main view for indicating structure made of connecting the squeeze bottle of multiple an embodiment of the invention.Such as Fig. 2 It is shown, it can be formed with the state for being connected to the squeeze bottle 1 of 2 or more (for 5 in Fig. 2).At this point, can be with squeeze bottle The side of the side and/or lid 6 of the side of 1 receiving portion 3 and/or the side of lid 6 and the receiving portion 3 of other adjacent squeeze bottles 1 The state of face part connection is formed, and 1 squeeze bottle is separated from the squeeze bottle of multiple connections.

The squeeze bottle of present embodiment is the discharge container of the liquid composition of discharge receiving.Liquid composition passes through dropwise addition Or it pours out and is discharged to outside squeeze bottle.

The container body of the squeeze bottle of present embodiment include the resin containing cyclic olefin and polyethylene kind (sometimes Write a Chinese character in simplified form work " resin containing cyclic olefin and polyethylene kind ").

As cyclic olefin, such as cyclic olefin polymer (also writing a Chinese character in simplified form work " COP " sometimes), cyclic olefin can be enumerated Copolymer (also writes a Chinese character in simplified form work " COC ") sometimes.From the angle for playing effect brought by the present invention more significantly, as ring-type Olefines, preferably COC.

As long as cyclic olefins COP two or more containing polymer made of copolymerization individually a kind of cyclic olefin or copolymerization Made of polymer or these polymer hydride, then be not particularly limited.The open loop that COP preferably comprises cyclic olefin is poly- Close object or its hydride.In addition, COP preferably comprises unbodied polymer.

As long as COC does not have containing polymer or their hydride made of copolymerization cyclic olefin and non-cyclic olefin Especially limitation.

As cyclic olefin, such as monocyclic or polycycle cycloalkane, monocyclic or more with vinyl can be enumerated Ring type cycloolefin and their derivative.As cyclic olefin, preferably norbornene, tetracyclododecane and their derivative Object.As non-cyclic olefin, such as the alpha-olefins such as ethylene, propylene, 1- butylene, 1- amylene, 1- hexene can be enumerated.

It preferably comprises from the angle for playing effect brought by the present invention more significantly as COP and has norborneol The polymer of the cyclic olefin of alkene skeleton or its hydride.Go out from the angle for playing effect brought by the present invention more significantly Hair preferably comprises the polymer as made of norbornene and ethylene copolymer as COC.In addition, by cyclic olefin and non-annularity Constituent in polymer made of olefin-copolymerization, containing other monomers as the polymer.

The glass transition temperature of cyclic olefin for example can be 60~200 DEG C, 60~180 DEG C, 60~160 DEG C, 60 ~150 DEG C, 60~140 DEG C, 65~130 DEG C, 65~120 DEG C, 65~110 DEG C, 65~100 DEG C or 65~90 DEG C.Vitrifying turns Temperature can be measured by the method on the basis of ISO11375.

Cyclic olefin is not particularly limited, and commercial goods can be used.As the COP of commercial goods, such as can enumerate ZEONEX (registered trademark) (ZEON CORPORATION manufacture), ZEONOR (registered trademark) (ZEON CORPORATION system It makes).As the COC of commercial goods, for example, can enumerate TOPAS (registered trademark) (Polyplastics Co., Ltd manufacture), APEL (registered trademark) (Mitsui Chemicals, Inc. manufacture).

As polyethylene (PE) class, such as high density polyethylene (HDPE) (HDPE), medium density polyethylene (MDPE), low can be enumerated Density polyethylene (LDPE), linear low density polyethylene (LLDPE).From the angle for playing effect brought by the present invention more significantly Degree sets out, as polyethylene kind, preferably LDPE, LLDPE, more preferable LLDPE.

Polyethylene kind can be homopolymer, or copolymer.As comonomer, 1- butylene, 1- penta can be enumerated The alpha-olefins such as alkene, 1- hexene, 1- octene, 1- decene.

The density of polyethylene kind for example can be 0.900~0.980kg/m³, 0.900~0.942kg/m³, 0.902~ 0.940kg/m³, 0.902~0.930kg/m³, 0.905~0.927kg/m³Or 0.908~0.920kg/m³。

Polyethylene kind is not particularly limited, and commercial goods can be used.As the polyethylene kind of commercial goods, such as can enumerate NOVATEC (registered trademark) (Japan Polyethylene Corporation manufacture), ULTZEX (registered trademark) out (Mitsui Chemicals, Inc. manufacture), EVOLUE (registered trademark) (Prime Polymer Co., Ltd. manufacture), UBE Polyethylene (registered trademark) B128H (UBE-MARUZEN POLYETHYLENE manufacture), umerit (registered trademark) (Prime Polymer Co., Ltd. manufacture), Petrothene (registered trademark) (TOSOH CORPORATION manufacture), Nipolon (registered trademark) (TOSOH CORPORATION manufacture), LUMITAC (registered trademark) (TOSOH CORPORATION Manufacture), suntec (registered trademark) (Asahi Kasei Corporation manufacture), Purell PE (registered trademark) (LyondellBasell Co., Ltd. manufacture).

Polypropylene (PP), poly- carbonic acid can for example be contained in the resin containing cyclic olefin and polyethylene kind of present embodiment Ester, (methyl) acrylic polymer, polystyrene (PS), polyethylene naphthalate (PEN), poly terephthalic acid second two The other polymers such as alcohol ester (PET) and polyarylate.In addition, the resin containing cyclic olefin and polyethylene kind of present embodiment can Contain stabilizer, modifying agent, colorant, ultraviolet absorbing agent, metal oxide, oxygen absorbent, antibacterial agent, plasticizer, glass fibers The additives such as dimension.In addition, preferably existing when the container body of squeeze bottle is made of 2 or more the layers containing internal layer and outer layer Outer layer contains these additives.

The container body of the squeeze bottle of present embodiment can be comprising the resin containing cyclic olefin and polyethylene kind Single layer structure is also possible to the multilayered structure for the layer for having comprising the resin containing cyclic olefin and polyethylene kind.Work as squeeze bottle Container body be multilayered structure when, i.e., when being made of 2 or more the layers containing internal layer and outer layer, comprising contain cyclic olefin And the layer of the resin of polyethylene kind can be the internal layer that connects with liquid composition, or not with the liquid composition phase The outer layer (or middle layer) connect, from the angle for playing effect brought by the present invention more significantly, preferably internal layer.This Outside, when the container body of squeeze bottle is multilayered structure and comprising the layer containing cyclic olefin and the resin of polyethylene kind is and liquid When the internal layer that shape composition connects, the type for forming the resin of outer layer (or middle layer) is not particularly limited, such as can contain choosing Free polyethylene (PE) class, polypropylene (PP), polyethylene terephthalate (PET), polystyrene (PS), acrylic nitrile-butadiene Styrene (ABS), polycarbonate, polymethyl methacrylate, ethylene vinyl acetate copolymer and ethylene-vinyl alcohol The polymer of one or more of the group of copolymer composition is as constituent.From playing effect brought by the present invention more significantly The angle of fruit is set out, as the resin for forming outer layer (or middle layer), preferably polyethylene (PE) class, polypropylene (PP), ethylene-second Enol copolymer, more preferable LDPE, LLDPE, PP, further preferred LDPE.

When the container body of the squeeze bottle of present embodiment is to include the list containing cyclic olefin and the resin of polyethylene kind When layer structure, or when the container body of the squeeze bottle of present embodiment is to have comprising containing cyclic olefin and polyethylene kind The multilayered structure of the layer of resin and include that the layer of the resin containing cyclic olefin and polyethylene kind connects with liquid composition When internal layer, layer (single layer or and the liquid comprising the resin containing cyclic olefin and polyethylene kind that connect with liquid composition The internal layer that composition connects) in the content of cyclic olefin be not particularly limited, can according to the type of cyclic olefin, other The type and content etc. for blending ingredient is appropriately configured.Go out from the angle for playing effect brought by the present invention more significantly Hair, as resin layer (single layer or and the liquid composition containing cyclic olefin and polyethylene kind to connect with liquid composition The internal layer to connect) in cyclic olefin content, such as using the total amount containing cyclic olefin and the resin of polyethylene kind as base Standard, the total content of cyclic olefin can be 10~99 mass %, 30~99 mass %, 50~99 mass %, 55~99 matter Measure %, 60~99 mass %, 65~99 mass %, 70~99 mass %, 75~96 mass %, 80~96 mass %, 85~96 Quality % or 90~96 mass %.

When the container body of the squeeze bottle of present embodiment is to include the list containing cyclic olefin and the resin of polyethylene kind Layer structure, or when the container body of the squeeze bottle of present embodiment is to have comprising the tree containing cyclic olefin and polyethylene kind The multilayered structure of the layer of rouge and include the resin containing cyclic olefin and polyethylene kind layer be connect with liquid composition in Layer when, connect with liquid composition containing cyclic olefin and polyethylene kind resin layer (single layer or with liquid composition phase The internal layer connect) in the content of polyethylene kind be not particularly limited, can according to the type of polyethylene kind, other blend the kind of ingredients Class and content etc. are appropriately configured.From the angle for playing effect brought by the present invention more significantly, as with liquid In the resin layer (single layer or the internal layer to connect with liquid composition) containing cyclic olefin and polyethylene kind that composition connects Polyethylene kind content, such as on the basis of the total amount containing cyclic olefin and the resin of polyethylene kind, polyethylene kind it is total Content can for 1~50 mass %, 5~50 mass %, 10~50 mass %, 15~50 mass %, 20~50 mass %, 25~ 45 mass %, 30~45 mass %, 35~45 mass % or 40~45 mass %.

The content of polyethylene kind in the container body of the squeeze bottle of present embodiment is not particularly limited, can be according to poly- second The type of alkenes, type and content of other blending ingredients etc. are appropriately configured.It is brought from the present invention is played more significantly The angle of effect set out, as the content of the polyethylene kind in container body, such as on the basis of the quality of container body, gather The total content of vinyl can for 10~95 mass %, 30~95 mass %, 35~90 mass %, 40~85 mass %, 40~ 83 mass %, 40~80 mass %, 45~78 mass %, 45~75 mass %, 45~70 mass %, 50~65 mass % or 50 ~60 mass %.

When the container body of the squeeze bottle of present embodiment is to include the list containing cyclic olefin and the resin of polyethylene kind When layer structure, or when the container body of the squeeze bottle of present embodiment is to have comprising containing cyclic olefin and polyethylene kind The multilayered structure of the layer of resin and include that the layer of the resin containing cyclic olefin and polyethylene kind connects with liquid composition When internal layer, resin layer (single layer or and the liquid composition containing cyclic olefin and polyethylene kind that connect with liquid composition The internal layer to connect) in polyethylene kind be not particularly limited relative to the blending ratio of cyclic olefin, can be according to cyclic olefin Class and the type of polyethylene kind, type and content of other blending ingredients etc. are appropriately configured.From playing this hair more significantly The angle of effect brought by bright is set out, as the resin containing cyclic olefin and polyethylene kind to connect with liquid composition Blending ratio of the polyethylene kind relative to cyclic olefin in layer (single layer or the internal layer to connect with liquid composition), such as phase For 1 mass parts of total content of cyclic olefin, the total content of polyethylene kind can be 0.01~9.0 mass parts, 0.01~2.5 Mass parts, 0.01~1.0 mass parts, 0.01~0.81 mass parts, 0.02~0.66 mass parts, 0.02~0.53 mass parts, 0.02~0.42 mass parts, 0.05~0.33 mass parts, 0.05~0.25 mass parts, 0.05~0.17 mass parts or 0.05~ 0.11 mass parts.

The resin of lid for forming the squeeze bottle of present embodiment is not particularly limited, from can be by blowing encapsulating (BFS) method The angle of container body and lid integrated molding is set out, resin preferably identical with container body.

From the angle for playing effect brought by the present invention more significantly, the pouring spout of the squeeze bottle of present embodiment The area of opening portion for example can be 0.15~20.0mm², 0.2~20.0mm², 0.2~18.0mm², 0.2~16.0mm²、 0.2~14.0mm², 0.2~12.6mm², 0.2~11.0mm², 0.2~9.7mm², 0.5~8.0mm², 0.79~7.1mm²、 0.79~6.2mm²Or 0.79~5.0mm².The area of the opening portion of pouring spout can be by using slide calliper rule, micrometer caliper, omnipotent Projector, stereomicroscope etc. measure the diameter of opening portion or major diameter and the minor axis of opening portion and are calculated.As long as in addition, energy It is enough to play effect brought by the present invention, then the shape of the opening portion of pouring spout can be carried out appropriately designed.From sending out more significantly The angle for waving effect brought by the present invention is set out, preferably circular or oval.

From the angle for playing effect brought by the present invention more significantly, the receiving portion of the squeeze bottle of present embodiment The compressive strength of side for example can be 20~250N/mm, 20~240N/mm, 20~230N/mm, 20~220N/mm, 20 ~210N/mm, 20~200N/mm, 20~190N/mm, 20~180N/mm, 20~170N/mm, 20~160N/mm, 20~ 150N/mm, 20~140N/mm, 20~130N/mm, 20~120N/mm, 20~110N/mm, 20~100N/mm, 20~90N/ Mm, 20~85N/mm, 20~80N/mm, 20~75N/mm, 20~70N/mm, 20~65N/mm, 20~60N/mm or 20~ 55N/mm.Herein, " side of receiving portion " includes the position usually held with finger when being added dropwise or pour out liquid composition.Separately Outside, when the section of the receiving portion of the squeeze bottle of present embodiment is (along the side vertical with the direction for being added dropwise or pouring out liquid composition To section) shape be round or oval when, " side of receiving portion " refers to " peripheral surface of receiving portion ".

The compressive strength of the side of receiving portion for example can be used accurate universal testing machine (Autograph AGS-X, Shimadzu Corporation manufacture), it is found out by following manner.Fig. 3 be indicate when receiving portion section (along be added dropwise or Pour out the section in the vertical direction in direction of liquid composition) shape when being round or oval, measure maximum test force The perspective view of method.In addition, on side (peripheral surface) 3a of receiving portion, being drawn in the short transverse of container body in Fig. 3 On dotted line indicate the part that connects with side (peripheral surface) 3a of receiving portion of plane 10.

1) it breaks seal the opening portion 5 of pouring spout 4, by the squeeze bottle 1 for not accommodating liquid composition with opening portion 5 towards lateral Mode is placed on plane 10 (for example, measurement platform of accurate universal testing machine).

2) it in side (peripheral surface) 3a of receiving portion, is used in dropwise addition or pours out the usual with finger tip of liquid composition The position 12 of grip is (at 1；It is also referred to as " maximum test force measurement site " below) it is contacted with measurement probe 11, it measures with 100mm/ The speed of min is squeezed to a half-distance (h/2) Shi Suoxu's of the distance between maximum test force measurement site 12 and plane 10 h The maximum value of power (hereinafter, also referred to as " maximum test force ").In addition, as measurement probe 11, suitably select its end face whole with The maximum test force measurement site 12 of side (peripheral surface) 3a of receiving portion connects and not through the side (periphery of receiving portion Surface) 3a shape probe.In addition, the bottom surface 3b of receiving portion is not the position for measuring maximum test force.

3) value with the maximum test force measured divided by the thickness of maximum test force measurement site is calculated according to following formula 1 (below also referred to as " maximum test force of per unit thickness ").

Maximum test force (N/mm)=maximum test force/measurement receiving portion side (outer weekly form of [formula 1] per unit thickness Face) maximum test force position thickness

4) for 5 squeeze bottles 1 with same composition and shape, the maximum examination of the per unit thickness of same area is calculated Power is tested, the average value (below also referred to as " average value of the maximum test force of per unit thickness ") of 5 be calculated value.

5) for multiple maximum test force measurement site 12 (3 in side (peripheral surface) 3a of the receiving portion of squeeze bottle 1 It is more than place), the average value of the maximum test force of per unit thickness is calculated, by the maximum of obtain 3 or more per unit thickness Minimum value in the average value of test force is as " compressive strength of the side (peripheral surface) of receiving portion ".

The section of the receiving portion of the squeeze bottle of present embodiment is (along vertical with the direction for being added dropwise or pouring out liquid composition The section in direction) shape can carry out it is appropriately designed.It is excellent from the angle for playing effect brought by the present invention more significantly It is selected as round, ellipse, rectangle or polygon, more preferably ellipse or rectangle.

From the angle for playing effect brought by the present invention more significantly, from pouring out for the squeeze bottle of present embodiment The dripping quantity for every drop that mouth is added dropwise can be set as 1~130 μ L, preferably 1~99 μ L, more preferably 1~79 μ L, further preferably 7~79 μ L are even more preferably 13~79 μ L.The dripping quantity of every drop can by by the area of the opening portion of pouring spout, receiving The compressive strength setting of the peripheral surface in portion is waited within the above range and is adjusted.

The capacity of the squeeze bottle of present embodiment is not particularly limited, and is appropriately configured depending on the application.In addition, squeezing Pressure bottle can be the container of the liquid composition of multiple (for example, the 25 times or more) usage amount of receiving, or few (example of receiving Such as, 2 times more than and less than 25 times) container of the liquid composition of usage amount can also be the liquid group of receiving single use amount Close the container of object.The squeeze bottle of present embodiment is preferably the container for accommodating the liquid composition of few time or single use amount.

When the squeeze bottle of present embodiment is, for example, to accommodate eye drops, contact lens wearing liquid, eyewash or nasal drop When container, capacity can be 0.01mL or more 50mL or less, 0.05mL or more 40mL or less, 0.1mL or more 25mL or less.When crowded Pressure bottle is, for example, to accommodate eye drops, contact lens wearing liquid, eyewash, nasal drop, educate mao agent or issue additional the container of agent, and using When the container of number be few time (for example, 2 times more than and less than 25 times) or single, capacity can for 0.01mL or more 7mL or less, 0.05mL or more 6mL or less, 0.1mL or more 5mL or less, 0.1mL or more 4mL or less, 0.1mL or more 3mL or less, 0.1mL with Upper 2.5mL or less, 0.2mL or more 2mL or less, 0.2mL or more 1.5mL or less, 0.2mL or more 1mL or less.

From can to visually observe the angle of confirmation foreign matter, confirmation surplus etc., the squeeze bottle of present embodiment Container body preferably has the transparency.It can be colourless, or have as long as the container body of squeeze bottle has the transparency Color.Guarantee as long as the container body of squeeze bottle has to be observed visually the transparency of the internal visibility of internal degree If ensuring above-mentioned internal visibility in a part of container body, the entire surface for not needing container body has The even transparency.As the transparency, such as the maximum of light transmittance of the squeeze bottle in the visible light region of 400~700nm of wavelength Value (below also referred to as " maximum transmission rate ") can for 50% or more, 55% or more, 60% or more, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more or 95% or more.Maximum transmission rate for example microplate reader etc. can be used to survey It is scheduled on the light transmittance of every 10nm between 400~700nm of wavelength, is found out by obtained each light transmittance.

From the angle for playing effect brought by the present invention more significantly, the container master of the squeeze bottle of present embodiment The thickness of body for example can for 0.01~2.0mm, 0.05~1.8mm, 0.08~1.5mm, 0.08~1.2mm, 0.08~ 1.0mm, 0.08~0.8mm, 0.1~0.6mm, 0.1~0.5mm or 0.1~0.4mm.When the appearance of the squeeze bottle of present embodiment When device main body is made of 2 or more layers, from the angle for playing effect brought by the present invention more significantly, comprising containing ring The thickness of the layer of the resin of shape olefines and polyethylene kind for example can for 0.01~1.0mm, 0.05~0.8mm, 0.08~ 0.6mm, 0.08~0.5mm, 0.08~0.4mm, 0.08~0.3mm or 0.1~0.2mm.

As long as the liquid composition being housed in the squeeze bottle of present embodiment has the receiving portion that can be filled in container Mobility.

As long as pharmaceutically, being housed in present embodiment pharmacologically (in pharmacy) or in the range of physiologically allowing Squeeze bottle in the viscosity of liquid composition be not particularly limited.It is viscous as the viscosity of liquid composition, such as using rotation It is viscous at 20 DEG C of degree meter (RE550 type viscosimeter, TOKI SANGYO CO., LTD. manufacture, rotor: 1 ° of 34 ' × R24) measurement Degree can be 0.5~1000mPa 〃 s, 0.8~500mPa 〃 s, 1.0~250mPa 〃 s, 1.0~100mPa 〃 s, 1.0~80mPa 〃 S, 1.0~70mPa 〃 s, 1.0~60mPa 〃 s, 1.0~50mPa 〃 s, 1.0~40mPa 〃 s, 1.0~30mPa 〃 s, 1.0~ 25mPa 〃 s, 1.0~20mPa 〃 s, 1.0~15mPa 〃 s, 1.0~10mPa 〃 s, 1.0~8.0mPa 〃 s, 1.0~7.0mPa 〃 s, 1.0~6.0mPa 〃 s, 1.0~5.0mPa 〃 s, 1.0~4.0mPa 〃 s, 1.0~3.0mPa 〃 s or 1.0~2.0mPa 〃 s.

The liquid composition being housed in the squeeze bottle of present embodiment can be water-based composition, or oiliness group Close object, preferably water-based composition.In addition, as the specific of the liquid composition in the squeeze bottle for being housed in present embodiment Example, such as the external applications liquid compositions such as ophthalmic composition, ear nose section composition, skin composition can be enumerated, taken orally With liquid composition, preferably ophthalmic composition.

When the liquid composition in the squeeze bottle for being housed in present embodiment is water-based composition, from playing more significantly The angle of effect brought by the present invention is set out, and as the content of water, such as on the basis of the total amount of liquid composition, water contains Amount can for 15w/v% more than and less than 100w/v%, 20w/v% more than and less than 100w/v%, 25w/v% more than and less than 99.5w/v%, 30w/v% more than and less than 99.5w/v%, 40w/v% more than and less than 99.2w/v%, 50w/v% or more and Less than 99.2w/v%, 60w/v% more than and less than 99.2w/v%, 70w/v% more than and less than 99w/v%, 80w/v% or more And it is less than 99w/v%, 85w/v% more than and less than 99w/v% or 90w/v% more than and less than 98.5w/v%.

When the liquid composition in the squeeze bottle for being housed in present embodiment is ophthalmic composition, as squeeze bottle Type, specifically, can be for example eye drip container, collyrium accepting container, contact lens wearing liquid accepting container, stealthy eye Mirror nursing liquid accepting container (including contact lens cleaning solution accepting container, contact lenses save liquid accepting container, contact lenses Thimerosal accepting container, contact lenses multifunction nursing liquid accepting container etc.).The type of squeeze bottle is preferably eye drip container, washes Ocular fluid accepting container, contact lens wearing liquid accepting container, contact lens care liquid accepting container.In addition, present embodiment Operability of the squeeze bottle in the liquid composition that discharge (be added dropwise or pour out) accommodates it is excellent, therefore can be according to user's It is intended to discharge liquid composition.Particularly suitable as discharge container, the i.e. eye drip container for storing liquid composition, the liquid Shape composition is used to be prone to eye closure reflex and pain or damage as caused by drying when in use and suitable application region is lesser Eye.In addition, " contact lenses " include hard contact lens, soft contact lens (both comprising ionic and nonionic, Include both silicone hydrogel contact lenses and non-silicone hydrogel contact lenses).

The squeeze bottle of present embodiment can for example be manufactured by encapsulating (BFS) method of blowing recorded in patent document 1.Tool For body, the squeeze bottle containing the container body being made of single layer can manufacture by the following method: by as squeeze bottle material Material carries out extrusion molding containing the resin of cyclic olefin and polyethylene kind, and parison is made.Then, it is pressed from both sides using split mold Hold obtained parison, by be internally pressed into air or the vacuum hole by being arranged on metal die surface to parison carry out Suction, is thus formed (blowing step) to each section of the container body of squeeze bottle, and liquid combination is filled in receiving portion Object (filling work procedure).Then, it can be clamped by using split mold and carry out shaping cover, the opening portion for sealing pouring spout is (close Seal process).Other than using the multilayered structure parison made of the conventional method in multi-layer blow molding, containing by multiple The squeeze bottle for the container body that layer is constituted, can be by identical as the above-mentioned squeeze bottle containing the container body being made of single layer is manufactured Method manufactured.In addition, as long as the layer structure of multilayered structure parison layer structure according to required by squeeze bottle carries out suitably Setting.

The squeeze bottle of present embodiment also can be used as contained in the squeeze bottle liquid composition product (eye drops, Eyewash, contact lenses Related product, toner, beautifying liquid, hair growth liquor, cosmetics, scalp care agent, educate a mao agent, additional issue agent, Beverage etc.) and provide.