阅读说明：本技术 离体器官灌注设备 (Isolated organ perfusion equipment ) 是由 陈静瑜 卫栋 于 2019-08-26 设计创作，主要内容包括：本发明涉及一种离体器官灌注设备,包括：控制装置和容器组件,控制装置包括灌注组件和控制器,灌注组件包括用于提供灌注动力的第一动力泵,第一动力泵与控制器电性连接,容器组件包括托盘、支撑膜和动力泵头,支撑膜固定设置在托盘上以支撑离体器官,托盘的底部设有用于容置灌注液的储液槽,储液槽设有第一出液口,支撑膜上开设用于与储液槽连通的通孔,动力泵头与第一动力泵的输出端连接,动力泵头设有用于与第一出液口管路连通的第一进液接口和用于与离体器官的动脉管路连通的第一出液接口,上述离体器官灌注设备可在常温环境下实现离体器官的长时间保存,提升移植手术的成功率。(The present invention relates to a kind of isolated organ perfusion equipments, it include: control device and container assemblies, control device includes perfusion component and controller, perfusion component includes for providing the first kinetic pump of perfusion power, first kinetic pump and controller are electrically connected, container assemblies include pallet, support membrane and power pump head, support membrane is fixed on pallet to support isolated organ, the bottom of pallet is equipped with the reservoir for accommodating perfusion liquid, reservoir is equipped with the first liquid outlet, the through-hole for being connected to reservoir is opened up on support membrane, power pump head is connect with the output end of the first kinetic pump, power pump head be equipped with for the first feed liquor interface of the first liquid outlet pipeline connection and for the arterial line with isolated organ be connected to first out liquid interface, above-mentioned isolated organ perfusion equipment can realize the long-time of isolated organ under normal temperature environment It saves, promotes the success rate of transfer operation.)

1. a kind of isolated organ perfusion equipment, which is characterized in that the isolated organ perfusion equipment includes: control device and appearance Device assembly, the control device include perfusion component and controller, and the perfusion component includes being perfused the of power for providing One kinetic pump, first kinetic pump and the controller are electrically connected, and the container assemblies include pallet, support membrane and power Pump head, the support membrane are fixed on the pallet to support isolated organ, and the bottom of the pallet is equipped with for accommodating The reservoir of perfusion liquid, the reservoir are equipped with the first liquid outlet, open up on the support membrane for being connected to the reservoir Through-hole, the power pump head connect with the output end of first kinetic pump, and the power pump head is equipped with for described the First feed liquor interface of one liquid outlet pipeline connection and for being connected to the arterial line of the isolated organ first go out liquid connect Mouthful.

2. a kind of isolated organ perfusion equipment according to claim 1, which is characterized in that the isolated organ is Isolated-lung Dirty, the control device further includes breathing component, and the breathing component includes ventilator, the ventilator and controller electricity Property connection, the ventilator is equipped with air feed interface and return-air interface, the air feed interface, the tracheae of the in vitro lungs and described Successively pipeline connection forms circulatory and respiratory gas circuit to return-air interface.

3. a kind of isolated organ perfusion equipment according to claim 2, which is characterized in that the breathing component further includes using In the battery powered to the ventilator.

4. a kind of isolated organ perfusion equipment according to claim 2, which is characterized in that the breathing component further includes using In the first operator control panel for showing and inputting respiratory function parameter, first operator control panel and the controller are electrically connected.

5. a kind of isolated organ perfusion equipment according to claim 1, which is characterized in that the control device further includes changing Hot component, the heat-exchanging component include insulating box and the second kinetic pump, and the insulating box is for accommodating heat exchange liquid, the insulating box The interior heating member being equipped with for heating the heat exchange liquid, the container assemblies further include going out liquid in described first by piping connection Oxygenator between interface and the artery, the insulating box and the oxygenator form circulating picture-changing heat pipe by pipeline connection Road, second kinetic pump are used to provide the described the dynamic power of heat exchange liquid recycle stream, the perfusion liquid in the oxygenator with The heat exchange liquid carries out heat exchange, and second kinetic pump and the heating member are electrically connected with the controller.

6. a kind of isolated organ perfusion equipment according to claim 5, which is characterized in that the perfusion component further includes One temperature detecting module, first temperature detecting module are used to detect the temperature of the perfusion liquid, first temperature detection Module and the controller are electrically connected.

7. a kind of isolated organ perfusion equipment according to claim 5, which is characterized in that the container assemblies further include white Cell filter, the leucocyte filter is by piping connection between the oxygenator and the artery.

8. a kind of isolated organ perfusion equipment according to claim 5, which is characterized in that the container assemblies further include micro- Bolt filter, the Micro- Bolt Filter by piping connection between the oxygenator and the artery or the power pump head with Between the oxygenator.

9. a kind of isolated organ perfusion equipment according to claim 1, which is characterized in that the control device further includes Two peristaltic pumps and third peristaltic pump, the container assemblies further include Huan Ye mechanism, and the Huan Ye mechanism includes dialyzer, waste liquid tank And sealant supplement cylinder, the reservoir are additionally provided with the second liquid outlet, the dialyzer simultaneously with the waste liquid tank, the sealant supplement cylinder and institute The second liquid outlet pipeline connection is stated, second peristaltic pump is used to provide to the perfusion liquid flowed out from second liquid outlet The power for entering the waste liquid tank and the sealant supplement cylinder after the dialyzer is flowed through, the sealant supplement cylinder and the reservoir pipeline connect Logical, the third peristaltic pump is set on the pipeline between the sealant supplement cylinder and the reservoir, second peristaltic pump and described Third peristaltic pump is electrically connected with the controller.

10. -9 described in any item a kind of isolated organ perfusion equipments according to claim 1, which is characterized in that the perfusion group Part further includes first pressure detection module, and the first pressure detection module is for detecting the perfusion liquid for flowing into the artery Pressure, the first pressure detection module and the controller are electrically connected.

11. -9 described in any item a kind of isolated organ perfusion equipments according to claim 1, which is characterized in that the perfusion group Part further includes flow detection module, and the flow detection module is used to detect the flow of the perfusion liquid, the flow detection mould Block and the controller are electrically connected.

12. -9 described in any item a kind of isolated organ perfusion equipments according to claim 1, which is characterized in that the perfusion group Part further includes the second operator control panel for showing and inputting perfusion functional parameter, and second operator control panel and the controller are electrical Connection.

13. -9 described in any item a kind of isolated organ perfusion equipments according to claim 1, which is characterized in that the perfusion group Part further includes the second battery for powering to first kinetic pump.

14. -9 described in any item a kind of isolated organ perfusion equipments according to claim 1, which is characterized in that the control dress Setting further includes alarm module, and the alarm module and the controller are electrically connected.

15. -9 described in any item a kind of isolated organ perfusion equipments according to claim 1, which is characterized in that the control dress Setting further includes communication module and mobile terminal, and the communication module and the controller are electrically connected, the mobile terminal and institute State communication module electric connection.

16. -9 described in any item a kind of isolated organ perfusion equipments according to claim 1, which is characterized in that the support membrane It is recessed to close to the reservoir direction.

17. -9 described in any item a kind of isolated organ perfusion equipments according to claim 1, which is characterized in that the control dress Setting further includes shell, and the first inner chamber for accommodating the perfusion component is equipped in the shell, and the container assemblies are set to institute It states on shell, the shell is equipped with the opening for being placed in the first inner chamber for the power pump head, the power pump head It is detachably connected with the output end of first kinetic pump.

18. a kind of isolated organ perfusion equipment according to claim 17, which is characterized in that be additionally provided with peace on the shell Door is filled, the installation door is corresponding with the first inner chamber position.

Technical field

The present invention relates to medical assistance equipment technology fields, more particularly to a kind of isolated organ perfusion equipment.

Background technique

When carrying out organ transplant, the preservation of organ can directly determine the success or failure of transfer operation.

Currently, the method that low temperature static preservation is usually used carries out the preservation of isolated organ, i.e., device is reduced by low temperature Function consumption, the holding time of Lai Yanchang organ.

But prolonged low temperature environment, histocyte can be caused to be damaged on isolated organ, organ ischemia etc. asks Topic, to reduce the success rate of transfer operation.

Summary of the invention

Based on this, it is necessary in view of the above technical problems, a kind of isolated organ perfusion equipment is provided, by continuing in vitro Organ perfusion's perfusion liquid to realize that the long-time of isolated organ saves under normal temperature environment, and then effectively avoids low temperature environment institute The problems such as bring such as histocyte is damaged, organ ischemia, promotes the success rate of transfer operation.

To achieve the above object, the present invention provides a kind of isolated organ perfusion equipment, the isolated organ perfusion equipment It include: control device and container assemblies, the control device includes perfusion component and controller, and the perfusion component includes being used for The first kinetic pump of perfusion power is provided, first kinetic pump and the controller are electrically connected, and the container assemblies include Pallet, support membrane and power pump head, the support membrane are fixed on the pallet to support isolated organ, the pallet Bottom is equipped with the reservoir for accommodating perfusion liquid, and the reservoir is equipped with the first liquid outlet, opens up and be used on the support membrane The through-hole being connected to the reservoir, the power pump head are connect with the output end of first kinetic pump, the power pump head Equipped with for the first feed liquor interface with the first liquid outlet pipeline connection and for the arterial line with the isolated organ The first of connection goes out liquid interface.

Above-mentioned isolated organ perfusion equipment compared with the background art, at least has the advantages that in vitro device first Official is placed on support membrane, and perfusion liquid is injected in reservoir, and the first feed liquor interface of power pump head is then passed through pipeline It is connected to the first liquid outlet of reservoir, goes out liquid interface for the first of power pump head and connected by the artery of pipeline and isolated organ It is logical, power on later, controller controls the operating of the first kinetic pump, and driving perfusion liquid flows in pipeline, and perfusion liquid is from liquid storage Slot the first liquid outlet outflow after, followed by the first feed liquor interface, first go out liquid interface and artery, finally from isolated organ to Circulating for perfusion liquid is so realized in outer discharge, and the through-hole through support membrane is back in reservoir, thus realize continue to Perfusion liquid is perfused in isolated organ, to realize that the long-time of isolated organ saves under normal temperature environment, and then effectively avoids low temperature ring The problems such as such as histocyte brought by border is damaged, organ ischemia；Meanwhile perfusion liquid is driven to follow by the first kinetic pump Circulation is dynamic, can effectively remove thrombus, inflammatory factor or other foreign matter harmful substances in isolated organ, and then can maintain in vitro The function vascular patency of organ, so as to improve pulmonary edema, improve cardiopulmonary oxygen conjunction ability etc., and can to isolated organ into Row repairing and treating reduces the risk that postoperative graft loses function, effectively promoted donor organ utilization rate and transfer operation at Power.

In one embodiment, the isolated organ is in vitro lungs, and the control device further includes breathing component, institute Stating breathing component includes ventilator, and the ventilator and the controller are electrically connected, the ventilator be equipped with air feed interface and Return-air interface, successively pipeline connection formation circulation is exhaled for the air feed interface, the tracheae of the in vitro lungs and the return-air interface Air-breathing road.

In one embodiment, the breathing component further includes the battery for powering to the ventilator.

In one embodiment, the breathing component further includes the first behaviour for showing and inputting respiratory function parameter Work shields, and first operator control panel and the controller are electrically connected.

In one embodiment, the control device further includes heat-exchanging component, the heat-exchanging component include insulating box and Second kinetic pump, the insulating box are equipped with the heating for heating the heat exchange liquid for accommodating heat exchange liquid in the insulating box Part, the container assemblies further include going out the oxygenator between liquid interface and the artery, institute in described first by piping connection It states insulating box and the oxygenator and circulating heat exchanging pipe is formed by pipeline connection, second kinetic pump, which is used to provide the described, to be changed The power of hydrothermal circulation flowing, the perfusion liquid carry out heat exchange in the oxygenator with the heat exchange liquid, and described second is dynamic Power pump and the heating member are electrically connected with the controller.

In one embodiment, the perfusion component further includes the first temperature detecting module, first temperature detection Module is used to detect the temperature of the perfusion liquid, and first temperature detecting module and the controller are electrically connected.

In one embodiment, the container assemblies further include leucocyte filter, and the leucocyte filter passes through Piping connection is between the oxygenator and the artery.

In one embodiment, the container assemblies further include Micro- Bolt Filter, and the Micro- Bolt Filter passes through pipeline Be connected between the oxygenator and the artery or the power pump head and the oxygenator between.

In one embodiment, the control device further includes the second peristaltic pump and third peristaltic pump, the container group Part further includes Huan Ye mechanism, and the Huan Ye mechanism includes dialyzer, waste liquid tank and sealant supplement cylinder, and the reservoir is additionally provided with second and goes out Liquid mouth, for the dialyzer simultaneously with the waste liquid tank, the sealant supplement cylinder and the second liquid outlet pipeline connection, described second is compacted Dynamic pump for after flowing through the dialyzer from the perfusion liquid offer that second liquid outlet flow out into the waste liquid tank With the power of the sealant supplement cylinder, the sealant supplement cylinder and the reservoir pipeline connection, the third peristaltic pump are set to the fluid infusion On pipeline between tank and the reservoir, second peristaltic pump and the third peristaltic pump electrically connect with the controller It connects.

In one embodiment, the perfusion component further includes first pressure detection module, the first pressure detection Module is used to detect the pressure for the perfusion liquid for flowing into the artery, the first pressure detection module and controller electricity Property connection.

In one embodiment, the perfusion component further includes flow detection module, and the flow detection module is used for The flow of the perfusion liquid is detected, the flow detection module and the controller are electrically connected.

In one embodiment, the perfusion component further includes the second behaviour for showing and inputting perfusion functional parameter Work shields, and second operator control panel and the controller are electrically connected.

In one embodiment, the perfusion component further includes the second electric power storage for powering to first kinetic pump Pond.

In one embodiment, the control device further includes alarm module, the alarm module and the controller It is electrically connected.

In one embodiment, the control device further includes communication module and mobile terminal, the communication module with The controller is electrically connected, and the mobile terminal and the communication module are electrically connected.

In one embodiment, the support membrane is recessed to close to the reservoir direction.

In one embodiment, the control device further includes shell, is equipped in the shell for accommodating the filling The first inner chamber of component is infused, the container assemblies are set on the shell, and the shell is equipped with for supplying the power pump head It is placed in the opening of the first inner chamber, the output end of the power pump head and first kinetic pump is detachably connected.

In one embodiment, installation door, the installation door and the first inner chamber position are additionally provided on the shell It is corresponding.

Detailed description of the invention

Fig. 1 is the structural schematic diagram of isolated organ perfusion equipment described in one embodiment of the invention；

Fig. 2 is the schematic diagram of internal structure of the control device in isolated organ perfusion equipment shown in Fig. 1；

Fig. 3 is the schematic diagram of internal structure of the container assemblies in isolated organ perfusion equipment shown in Fig. 1；

Fig. 4 is the structural schematic diagram of the pallet in container assemblies shown in Fig. 3；

Fig. 5 is the structural schematic diagram of the power pump head of the container assemblies in isolated organ perfusion equipment shown in Fig. 1；

Fig. 6 is the partial sectional view of the container assemblies in isolated organ perfusion equipment shown in Fig. 1；

Fig. 7 is the structural schematic diagram of the oxygenator in container assemblies shown in Fig. 3；

Fig. 8 is the structural schematic diagram of the leucocyte filter in container assemblies shown in Fig. 3；

Fig. 9 is the structural schematic diagram of the Micro- Bolt Filter in container assemblies shown in Fig. 3；

Figure 10 is the attachment structure schematic diagram of the container assemblies in isolated organ perfusion equipment shown in Fig. 1；

Figure 11 is the attachment structure schematic diagram of the heat-exchanging component in control device shown in Fig. 2.

10, control device, the 111, first kinetic pump, the 112, first temperature detecting module, 113, flow detection module, 114, Second operator control panel, the 115, second battery, 121, ventilator, 1211, air feed interface, 1212, return-air interface, 1213, oxygen connects Entrance, 1214, air access port, the 122, first operator control panel, 131, insulating box, 1311, heating member, 1312, heat exchange liquid import, 1313, heat exchange liquid outlet, 1314, second temperature detection module, 1315, drain valve, the 132, second kinetic pump, 14, shell, 141, Opening, 142, installation door, 15, infusion strut, 20, container assemblies, 21, pallet, 211, support membrane, 2111, through-hole, 212, liquid storage Slot, the 2121, first liquid outlet, the 2122, second liquid outlet, 22, power pump head, the 221, first feed liquor interface, 222, first goes out liquid Interface, 23, cover, 24, oxygenator, the 241, second feed liquor interface, 242, second goes out liquid interface, 243, heat exchange import, and 244, change Heat outlet, 25, leucocyte filter, 251, third feed liquor interface, 252, third go out liquid interface, 26, Micro- Bolt Filter, 261, the Four feed liquor interfaces, the 262, the 4th goes out liquid interface, 27, waste liquid tank, 28, sealant supplement cylinder, 29, dialyzer, the 30, second peristaltic pump, and 40, the Three peristaltic pumps.

Specific embodiment

To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing Give better embodiment of the invention.But the invention can be realized in many different forms, however it is not limited to herein Described embodiment.On the contrary, the purpose of providing these embodiments is that making to understand more the disclosure Add thorough and comprehensive.

It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to To another element or it may be simultaneously present centering elements.On the contrary, when element is referred to as " directly existing " another element "upper", There is no intermediary elements.Heretofore described " first ", " second ", " third ", " the 4th " do not represent specific quantity and sequence, It is only used for the differentiation of title.

As shown in Fig. 1 to 5, a kind of isolated organ perfusion equipment, be applicable in normal temperature environment to such as in vitro lungs, The isolated organs such as isolated heart carry out long-time preservation, while being also applied for repairing isolated organ, which includes: control Device 10 and container assemblies 20 processed, control device 10 include perfusion component and controller (not identifying in attached drawing), and component is perfused Including for providing the first kinetic pump 111 of perfusion power, the first kinetic pump 111 is electrically connected with controller, container assemblies 20 Including pallet 21, support membrane 211 and power pump head 22, support membrane 211 is fixed on pallet 21 to support isolated organ, support The bottom of disk 21 is equipped with the reservoir 212 for accommodating perfusion liquid, and reservoir 212 is equipped with the first liquid outlet 2121, support membrane 211 On open up through-hole 2111 for being connected to reservoir 212, power pump head 22 is connect with the output end of the first kinetic pump 111, is moved Power pump head 22 is equipped with for the first feed liquor interface 221 with 2121 pipeline connection of the first liquid outlet and for dynamic with isolated organ The first of arteries and veins pipeline connection goes out liquid interface 222.

In the application, isolated organ is placed on support membrane 211 first, and injects perfusion liquid in reservoir 212, connect The first feed liquor interface 221 of power pump head 22 is connected to by pipeline with the first liquid outlet 2121 of reservoir 212, by power The first of pump head 22 goes out liquid interface 222 and be connected to the artery of isolated organ by pipeline, powers on later, and controller controls the The operating of one kinetic pump 111, driving perfusion liquid flow in pipeline, and perfusion liquid is flowed out from the first liquid outlet 2121 of reservoir 212 Afterwards, go out liquid interface 222 and artery followed by the first feed liquor interface 221, first, finally discharged from isolated organ, and pass through The through-hole 2111 of support membrane 211 is back in reservoir 212, so realizes that perfusion liquid circulates, thus realize continue to Perfusion liquid is perfused in isolated organ, to realize that the long-time of isolated organ saves under normal temperature environment, and then effectively avoids low temperature ring The problems such as such as histocyte brought by border is damaged, organ ischemia；Meanwhile it being driven and being perfused by the first kinetic pump 111 Liquid recycle stream is dynamic, can effectively remove thrombus, inflammatory factor or other foreign matter harmful substances in isolated organ, and then can maintain The function vascular patency of isolated organ, so as to improve pulmonary edema, raising cardiopulmonary oxygen conjunction ability etc., and can be in vitro Organ carries out repairing and treating, reduces the risk that postoperative graft loses function, effectively promotes the utilization rate and transplanting hand of donor organ The success rate of art.

Specifically, incorporated by reference to Fig. 3, through-hole 2111 has multiple, and multiple through-holes 2111 are evenly distributed on support membrane 211 On.

Specifically, please continue to refer to Fig. 3, container assemblies 20 further include cover 23, and pallet 21 and support membrane 211 are set to cover In body 23, isolated organ is sealed.

Specifically, perfusion liquid is mixed by DMEM/F12 medium component, albumin and 70 ratio of ficoll.

In one embodiment, incorporated by reference to Fig. 1 and Fig. 2, isolated organ is in vitro lungs, and control device 10 further includes breathing group Part, breathing component include ventilator 121, and ventilator 121 and controller are electrically connected, and ventilator 121 is equipped with air feed interface 1211 With return-air interface 1212, successively pipeline connection forms circulation for air feed interface 1211, the tracheae of in vitro lungs and return-air interface 1212 Breathing circuit.In vitro lungs both need that perfusion liquid is perfused when stored, while being also required to oxygen supply, after being powered up, control Device processed controls the first kinetic pump 111 of perfusion simultaneously and ventilator 121 starts, and the first kinetic pump 111 is conveying filling in vitro lungs While fluid injection, by being in vitro lungs sustainable supply oxygen by the tracheae pipeline connection of ventilator 121 and in vitro lungs, with In vitro lungs are kept to carry out multiple Zhang Yundong.

Specifically, incorporated by reference to Fig. 2, ventilator 121 is additionally provided with oxygen access port 1213 and air access port 1214, and oxygen connects Entrance 1213 is not for (showing that) pipeline connection with source of oxygen in attached drawing, air access port 1214 is used for and air compressor (not showing that in attached drawing) pipeline connection, oxygen and air supply in vitro lungs after ratio is mixed to form mixed gas, to protect It holds in vitro lungs and carries out multiple Zhang Yundong.

Further, please continue to refer to Fig. 2, breathing component further includes the first battery for powering to ventilator 121 (not identified in attached drawing), wherein the first battery is chosen as lithium battery, ickel-cadmium cell or Ni-H cell, particularly, to guarantee Power supply can be provided sustainedly and stably, and the first battery is preferably lithium battery.It transported in the event of a loss of power or in isolated organ Cheng Zhong, the first battery can be used as power supply and power to ventilator 121, with 121 continuous running of the machine of ensuring respiration, to make Isolated-lung Dirty holding carries out multiple Zhang Yundong, and in vitro lungs is effectively avoided to cause the case where damaging because respiratory function stops.

Further, please continue to refer to Fig. 1, breathing component further includes first for showing and inputting respiratory function parameter Operator control panel 122, the first operator control panel 122 are electrically connected with controller.User can need in the first operator control panel 122 according to experiment Corresponding respiratory function parameter is inputted, controller works according to above-mentioned respiratory function state modulator ventilator 121, effectively improves behaviour Make convenience.

In one embodiment, incorporated by reference to Fig. 2, Fig. 3 and Figure 11, control device 10 further includes heat-exchanging component, heat-exchanging component packet Insulating box 131 and the second kinetic pump 132 are included, insulating box 131 is equipped in insulating box 131 and changes for heating for accommodating heat exchange liquid The heating member 1311 of hydrothermal solution, container assemblies 20 further include going out the oxygenator between liquid interface and artery in first by piping connection 24, insulating box 131 and 24 pipeline connection of oxygenator form circulating heat exchanging pipe, and the second kinetic pump 132 is followed for providing heat exchange liquid The dynamic power of circulation, perfusion liquid carry out heat exchange in oxygenator 24 with heat exchange liquid, and the second kinetic pump 132 and heating member 1311 are equal It is electrically connected with controller.Please continue to refer to Figure 11, insulating box 131 and oxygenator 24 pass through pipeline connection formation circulating picture-changing heat pipe Road, power pump head 22, oxygenator 24, isolated organ are connected to form circumfusion pipeline with reservoir 212, and perfusion liquid is in oxygenator Heat exchange is carried out with heat exchange liquid in 24, to keep the temperature of perfusion liquid to be mutually suitable for isolated organ.

Specifically, incorporated by reference to Fig. 1 and Fig. 7, insulating box 131 is equipped with heat exchange liquid import 1312 and heat exchange liquid outlet 1313, oxygen Clutch 24 is equipped with the second feed liquor interface 241, second and goes out liquid interface 242, heat exchange import 243 and heat exchange outlet 244, reservoir 212 The first liquid outlet 2121, the first feed liquor interface 221 of power pump head 22, power pump head 22 first go out liquid interface 222, second Successively pipeline connection forms above-mentioned circumfusion pipeline to the artery of liquid interface 242 and isolated organ to feed liquor interface 241, second out, Successively pipeline connection forms above-mentioned follow for heat exchange liquid outlet 1313, heat exchange import 243, heat exchange outlet 244 and heat exchange liquid import 1312 Ring heat exchanging pipe.

Specifically, heat exchange liquid is chosen as aseptic deionized water.

In one embodiment, incorporated by reference to Fig. 2, it further includes the first temperature detecting module 112, the first temperature detection that component, which is perfused, Module 112 is used to detect the temperature of perfusion liquid, and the first temperature detecting module 112 is electrically connected with controller.First temperature detection Module 112 detect to the temperature of perfusion liquid and temperature data is fed back to controller in real time, when the temperature for detecting perfusion liquid When deviation occur in degree and set temperature, controller adjusts the heating power of heating member 1311, so that perfusion liquid is returned to setting temperature Degree, is further ensured that the temperature of perfusion liquid is mutually suitable for isolated organ.

Further, incorporated by reference to Figure 11, insulating box 131 is interior to be equipped with second temperature detection module 1314, second temperature detection Module 1314 and controller are electrically connected, and the temperature that second temperature detection module 1314 exchanges hydrothermal solution in real time carries out detection and will be warm Degree is according to controller is fed back to, and when deviation occur in the temperature and set temperature that detect heat exchange liquid, controller adjusts heating member 1311 heating power further guarantees the temperature and isolated organ of heat exchange liquid so that heat exchange liquid is returned to set temperature Mutually it is suitable for.

Specifically, incorporated by reference to Figure 11, insulating box 131 is additionally provided with drain valve 1315, after completing isolated organ perfusion operation Openable drain valve 1315 discharges the heat exchange liquid in insulating box 131, avoids long-time Seal and preservation and bacterium is caused to grow It is raw.

In one embodiment, incorporated by reference to Fig. 3, container assemblies 20 further include leucocyte filter 25, leucocyte filter 25 Through piping connection between oxygenator 24 and artery.Perfusion liquid from oxygenator 24 outflow after enter leucocyte filter 25 in into Row leukoreduction filter effectively reduces the damage that isolated organ occurs because being irrigated perfusion, while can effectively delay organ Naltrindole occurs, and further promotes the utilization rate of donor organ and the success rate of transfer operation.

Specifically, incorporated by reference to Fig. 8 and Figure 10, leucocyte filter 25 is equipped with third feed liquor interface 251 and third goes out liquid and connects Mouthfuls 252, third feed liquor interface 251 goes out 242 pipeline connection of liquid interface with second, and third goes out moving for liquid interface 252 and isolated organ Arteries and veins pipeline connection.

In one embodiment, incorporated by reference to Fig. 3, container assemblies 20 further include Micro- Bolt Filter 26, and Micro- Bolt Filter 26 passes through Piping connection is between oxygenator 24 and artery or between power pump head 22 and oxygenator 24.Perfusion liquid flow into oxygenator 24 before or Enter in Micro- Bolt Filter 26 after the outflow of oxygenator 24, Micro- Bolt Filter 26 is used to filter out various micro- bolts in perfusion liquid, prevents The embolism that the capilary of isolated organ is only caused because of various micro- bolts such as thrombus or aeroembolism, effectively improves the blood of human microvascular Perfusion further promotes the utilization rate of donor organ and the success rate of transfer operation.

Specifically, incorporated by reference to Fig. 9 and Figure 10, Micro- Bolt Filter 26 is equipped with the 4th feed liquor interface 261 and the 4th and goes out liquid interface 262, the 4th feed liquor interface 261 and second goes out 242 pipeline connection of liquid interface, and the 4th goes out the artery of liquid interface 262 and isolated organ Pipeline connection.

Further, incorporated by reference to Fig. 3, aforementioned two embodiment is combined, by leucocyte filter 25 and Micro- Bolt Filter 26 It is connected between oxygenator 24 and isolated organ simultaneously, wherein the connection between leucocyte filter 25 and Micro- Bolt Filter 26 Sequencing is unlimited, further the utilization rate of promotion isolated organ and the success rate of transfer operation.

In one embodiment, incorporated by reference to Fig. 6 and Figure 10, control device 10 further includes the second peristaltic pump 30 and third peristaltic pump 40, container assemblies 20 further include Huan Ye mechanism, and Huan Ye mechanism includes dialyzer 29, waste liquid tank 27 and sealant supplement cylinder 28, reservoir 212 Be additionally provided with the second liquid outlet 2122, dialyzer 29 simultaneously with 2122 pipeline connection of waste liquid tank 27, sealant supplement cylinder 28 and the second liquid outlet, Second peristaltic pump 30 be used for after flowing through dialyzer 29 from the offer of perfusion liquid that the second liquid outlet 2122 flow out into waste liquid tank 27 With the power of sealant supplement cylinder 28, sealant supplement cylinder 28 and 212 pipeline connection of reservoir, third peristaltic pump 40 are set to sealant supplement cylinder 28 and reservoir On pipeline between 212, the second peristaltic pump 30 and third peristaltic pump 40 are electrically connected with controller.Filling after repeatedly recycling Fluid injection is flowed out from the second liquid outlet 2122 of reservoir 212, and perfusion liquid flows through dialyzer 29 under the driving of the second peristaltic pump 30 Afterwards, a part flows into waste liquid tank 27, another part and the new filling flowed out under the driving of third peristaltic pump 40 from sealant supplement cylinder 28 Fluid injection accumulates to be flowed into reservoir 212 all the way, realizes the supplement displacement of perfusion liquid, and controller controls the second peristaltic pump 30 and the The revolving speed of three peristaltic pumps 40, to guarantee the perfusion liquid capacity constant in reservoir 212.

In one embodiment, perfusion component further includes first pressure detection module (not identifying in attached drawing), first pressure Detection module is used to detect the pressure for the perfusion liquid for flowing into artery, and first pressure detection module and controller are electrically connected.First Pressure detecting module real-time detection flows into the pressure of the perfusion liquid of artery and pressure data is fed back to controller, controller according to Above-mentioned pressure data controls the power of the first kinetic pump 111, to control the injection pressure of perfusion liquid, avoids injection pressure and in vitro Organ is not suitable for and causes the arterial injury of isolated organ, further promoted donor organ utilization rate and transfer operation at Power.

In one embodiment, incorporated by reference to Fig. 2, it further includes flow detection module 113, flow detection module 113 that component, which is perfused, For detecting the flow of perfusion liquid, flow detection module 113 and controller are electrically connected.113 real-time detection of flow detection module Data on flows is simultaneously fed back to controller by perfusion flow quantity, and controller controls the first kinetic pump 111 according to above-mentioned data on flows Power, to control the flow of perfusion liquid.

In one embodiment, incorporated by reference to Fig. 1, it further includes second for showing and inputting perfusion functional parameter that component, which is perfused, Operator control panel 114, the second operator control panel 114 are electrically connected with controller.User can need in the second operator control panel 114 according to experiment Corresponding perfusion functional parameter is inputted, controller works according to above-mentioned the first kinetic pump of perfusion functional state modulator 111, effectively mentions Height operation convenience.

In one embodiment, incorporated by reference to Fig. 2, it further includes that second for powering to the first kinetic pump 111 stores that component, which is perfused, Battery 115, wherein the second battery 115 is chosen as lithium battery, ickel-cadmium cell or Ni-H cell, particularly, to guarantee power supply energy It sustainedly and stably provides, the second battery 115 is preferably lithium battery.In the event of a loss of power or in isolated organ transport process In, the second battery 115 can be used as power supply and power to the first kinetic pump 111, to guarantee 111 continuous running of the first kinetic pump, from And guarantee to continue to be perfused perfusion liquid to isolated organ, effectively avoid isolated organ from causing the case where damaging because perfusion functional stops Occur.

In one embodiment, control device 10 further includes alarm module (not showing that in attached drawing), alarm module and control Device is electrically connected.When controller recognizes operation irregularity according to acquired supplemental characteristic, alarm module will start, with notice User takes corresponding measure in time, avoids working long hours exception and isolated organ is caused to damage, further promote donor device The utilization rate of official and the success rate of transfer operation.

In one embodiment, control device 10 further includes communication module (not showing that in attached drawing) and mobile terminal (attached drawing In do not show that), communication module and controller are electrically connected, and mobile terminal and communication module are electrically connected.Wherein, communication module It can be Internet of Things module, can include but is not limited to WIFI module, GPRS module, 3G module, 4G module etc., communication module will be from Generated related data uploads in the database in Cloud Server in body organ perfusion process, and transplanting expert can pass through movement Terminal checks above-mentioned data, periodically guards to isolated organ to facilitate and assesses isolated organ situation, to guarantee isolated organ It can obtain effectively saving for a long time.

In one embodiment, incorporated by reference to Fig. 3, support membrane 211 is recessed to close to 212 direction of reservoir, mentions for isolated organ For more shelf spaces, avoids isolated organ from being oppressed in filling process and cause to damage, particularly, support membrane 211 Flexible soft film can be used, such as Silicon moulds further avoid isolated organ and are damaged.

In one embodiment, incorporated by reference to Fig. 1, control device 10 further includes shell 14, is equipped in shell 14 and fills for accommodating The first inner chamber (not identifying in attached drawing) of component is infused, container assemblies 20 are set on shell 14, and shell 14 is equipped with for for dynamic Power pump head 22 is placed in the opening 141 of first inner chamber, and power pump head 22 and the output end of the first kinetic pump 111 are detachably connected. During installation, power pump head 22 is penetrated from opening 141 and connect installation with the first kinetic pump 111 afterwards, in filling process, Perfusion liquid is not in contact with control device 10, can be by power pump head 22 from the first kinetic pump 111 after completing perfusion operation It splits out, so that container assemblies 20 are unloaded and be thrown aside from control device 10, when carrying out next isolated organ perfusion operation, more The container assemblies 20 that renew and the installation of control device 10 connect, so that complete machine is more after the completion of avoiding each isolated organ from being perfused It changes, use cost is effectively reduced.

Specifically, it is additionally provided with the second inner chamber (not identifying in attached drawing) for accommodating breathing component in shell 14 and is used for Accommodate the third inner cavity (not identifying in attached drawing) of heat-exchanging component.

In one embodiment, please continue to refer to Fig. 1, installation door 142 is additionally provided on shell 14, in installation door 142 and first Chamber position is corresponding, and the openable installation door 142 of user carries out the attended operation of power pump head 22 and the first kinetic pump 111, improves Property easy to use.

Specifically, incorporated by reference to Fig. 2, be additionally provided with infusion strut 15 on shell 14, infusion strut 15 for hang bottled medicine, Surgical instrument etc. further increases property easy to use.Particularly, telescopic rod can be selected in infusion strut 15, to pass through telescopic adjustment Different height requirements is adapted to, property easy to use is further improved.

Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.

The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.