阅读说明：本技术 一种目镜式瞳孔对光反射自动检测设备 (A kind of eyepiece formula pupillary light reflex automatic checkout equipment ) 是由 陈伟 刘志勇 刘建仁 于 2019-05-05 设计创作，主要内容包括：本发明涉及一种目镜式瞳孔对光反射自动检测设备,包括相机,用于获取人眼图像；光刺激源,为用户提供至少一种刺激光源；距离测量传感器,用于测量相机到人眼的距离；以及对瞳孔进行补全的图像分析模块和根据数据测量传感器的数值及补全后的瞳孔图像获取瞳孔数据的数据分析模块。本发明的优点在于：便于携带、兼容性佳；提供了多种光源和声源,便于选择刺激类型,通过半反光镜满足暗室要求,通过红外补光灯对瞳孔进行补光,便于获取清晰图像；通过距离测量传感器,准确获取瞳孔与检测设备的距离；通过补全算法,能够准确提取瞳孔对光反射各项客观参数,非常适合神经科、眼科及精神科临床及科研需要。(The present invention relates to a kind of eyepiece formula pupillary light reflex automatic checkout equipments, including camera, for obtaining eye image；Polished bard stimulus provides at least one stimulating light source for user；Distance measurement sensor, the distance for measuring camera to human eye；And the image analysis module of completion is carried out to pupil and obtains the data analysis module of pupil data according to the pupil image after the numerical value of DATA REASONING sensor and completion.The present invention has the advantages that easy to carry, compatible good；Various light sources and sound source are provided, convenient for selection stimulus type, darkroom is met by semi reflective mirror and is required, light filling are carried out to pupil by infrared light compensating lamp, convenient for obtaining clear image；By distance measurement sensor, the accurate pupil that obtains is at a distance from detection device；By completion algorithm, pupillary light reflex items objective parameter can be accurately extracted, is very suitable to neurology department, ophthalmology and psychiatric department clinic and scientific research needs.)

1. a kind of eyepiece formula pupillary light reflex automatic checkout equipment, it is characterised in that: including

Camera, for obtaining eye image；

Polished bard stimulus provides at least one stimulating light source for user；

Distance measurement sensor, the distance for measuring camera to human eye；

And to the image analysis module of pupil progress completion and according to the pupil after the numerical value of distance measurement sensor and completion The data analysis module of image acquisition pupil data；

The signal output end of the camera and the signal input part of image analysis module communicate to connect, the letter of distance measurement sensor Number output end and data analysis module signal input part communicate to connect, and the signal output end and data of image analysis module analyze mould The signal input part of block communicates to connect.

2. a kind of eyepiece formula pupillary light reflex automatic checkout equipment according to claim 1, it is characterised in that: the figure The method that completion is carried out to pupil as analysis module are as follows:

Step A: obtaining image, extracts pupil edge, judges whether pupil is blocked；If pupil is blocked, go to step B, otherwise go to step E；

Step B: the center of circle of circle and radius where taking up an official post and three pixels is taken to calculate pupil at pupil edge, the step for repetition, Until all pixels point on traversal pupil edge；

Step C: minimum two journey methods are carried out to all centers of circle obtained in step B and radius and are fitted to obtain the center of circle of fitting circle and half Diameter；

Step D: variance analysis is carried out to fitting circle and pupil edge, judges whether fitting precision meets the requirements, if fitting precision It is unsatisfactory for requiring, adjusts fitting parameter, go to step C；If fitting precision is met the requirements, go to step E；

Step E: pupil edge data are transferred to data analysis module.

3. a kind of eyepiece formula pupillary light reflex automatic checkout equipment according to claim 2, it is characterised in that: work as fitting When the round variance confidence level with pupil edge is greater than 0.95, fitting precision is met the requirements.

4. a kind of eyepiece formula pupillary light reflex automatic checkout equipment according to claim 2, it is characterised in that: step A If area < 100 pixel in pupil point set envelope region, judges that pupil is blocked in；Otherwise judge that pupil is not blocked.

5. a kind of eyepiece formula pupillary light reflex automatic checkout equipment according to claim 1, it is characterised in that: the number When pupil data according to analysis module acquisition includes the incubation period of pupil change procedure, stable diameter, minimum diameter, pupil contraction Peak acceleration and maximum speed.

6. a kind of eyepiece formula pupillary light reflex automatic checkout equipment according to claim 5, it is characterised in that: the number The method for obtaining pupil data according to analysis module are as follows:

Step 1: setting filtering parameter is filtered the pupil data of complete stimulating course, putting down when calculating normal condition Minimum diameter when steady diameter and pupil minimum；

Step 2: to two o'clock corresponding on consecutive image, calculating speed and acceleration traverse all diameters of entire stimulating course Data obtain maximum speed and peak acceleration that pupil stress change；If there is continuously speed is greater than 10mm/s's three times Point, the then time started for stress reaction record the position data；

Step 3: output pupil data.

7. a kind of eyepiece formula pupillary light reflex automatic checkout equipment according to claim 1, it is characterised in that: further include Parameter setting module and single-chip microcontroller, signal input part and parameter setting module, the camera and range measurement of the single-chip microcontroller sense The signal output end of device communicates to connect, and the signal output end and polished bard stimulus of single-chip microcontroller, image analysis module and data analyze mould The signal input part of block communicates to connect；Instruction can be issued as single-chip microcontroller by the parameter setting module change the production of polished bard stimulus Raw luminous intensity, time and frequency.

8. a kind of eyepiece formula pupillary light reflex automatic checkout equipment according to claim 1, it is characterised in that: the light Stimulus further includes three groups of optical filters of red, green, blue；The pupil detection equipment further includes infrared light compensating lamp and by infrared light compensating lamp Light be reflected into the half-reflecting half mirror of pupil region, when pupil faces front, normal direction and the sight angle of half-reflecting half mirror are in 30 ~ 60 °, a length of 850 ~ 940nm of infrared waves that infrared light compensating lamp issues.

9. a kind of eyepiece formula pupillary light reflex automatic checkout equipment according to claim 7, it is characterised in that: further include The Sound stimulat source of signal input part and the communication connection of single-chip microcomputer signal output end, the Sound stimulat source can be according to parameter setting mould The instruction of block issues stimulation sound source.

10. a kind of eyepiece formula pupillary light reflex automatic checkout equipment according to claim 6, it is characterised in that: described Image analysis module, data analysis module and parameter setting module are integrated in computer software, and the computer software is electricity Brain software or cell phone software or embedded software or webpage.

Technical field

The present invention relates to pupil physiological datas to obtain equipment technical field more particularly to a kind of eyepiece formula pupillary light reflex Automatic checkout equipment.

Background technique

Pupillary light reflex is a kind of physiological phenomenon, refers to pupil when by radiation of visible light, pupil can reduce, and light source is removed Afterwards, pupil can restore to the original state rapidly.Pupil detection is usually required that and is carried out under darkroom, it is preferable to have fully closed shade Border.

As inspection method by a kind of neurology department simple bed of classics, pupillary light reflex neurotrosis, the disturbance of consciousness, Play a significant role in the judgement of brain disorder.With modern neuro the reach of science, more and more evidences prompt this Check equally has important reference value in terms of Parkinson's disease, cognitive disorder, dysautonomia, and has Hoping becomes a kind of electro physiology marker that can objectively respond disease subtypes.Traditionally, pupillary light reflex rely primarily on flashlight, Examiner is by checking by hand, visually observing completion assessment, and as a result relatively subjective, no quantitative analysis is not easy to multicenter number According to homogeneity management.Currently, quantitative pupillary light reflex checks equipment mainly from American-European countries in the market, price is high It is expensive, it is domestic still to lack the instrument for possessing independent intellectual property right.

Under normal circumstances, common people's pupil is 2 ~ 6 millimeters of diameter of circle, and two sides pupil size is essentially identical, by When light stimulation, analysis to the change procedure of pupil diameter, using certain algorithm, can obtain multiple parameters such as incubation period, The parameters such as the maximum speed of peak acceleration, pupil contraction when stable diameter, minimum diameter, pupil contraction.These data tool There is significant clinical meaning.

Pupillary light reflex quantitative detection usually uses camera acquisition pupil and is calculated by image analysis technology Then pupil diameter D as unit of pixel uses formula F: pupil actual size (M, unit are millimeter)=pupil diameter (D) * again The pupil actual physical size (K, unit are related at a distance from millimeter/pixel, with camera to pupil) that each pixel represents, obtains To the physics size of pupil.Pupil diameter is detected using electronically, it is necessary to the true of pupil is obtained according to aforementioned formula F Material object reason size.And current existing equipment, either fixed detection case or hand-held tester, camera and pupil Distance is not a stationary value, and different subjects is due to various reasons, it is impossible to accomplish that pupil and camera distance are consistent, because This, the problem of bringing is exactly the pupil diameter that existing equipment detected, since K is a definite value, but according to previous reasons, K It is practically impossible to be a definite value, there is the error for being difficult to eliminate so as to cause pupil actual size and test value.

In addition, the prior art there is problems:

1, existing detection device requires that pupil is complete in the image of acquisition, could effectively calculate pupil when handling pupil Diameter, and in actual clinical environment, subject is different in test to be surely completely exposed pupil, cannot be quasi- so as to cause pupil diameter Really calculate

2, stimulating light source fixed single cannot accomplish that multiple color light source switches

3, Sound stimulat cannot be provided

4, fixed detection case volume is larger, has certain requirement to inspection place, does not have portability.

5, hand-held tester does not have light-proofness.

Summary of the invention

In view of the above-mentioned problems, the application provides a kind of pupil detection that can eliminate influence of the distance change to pupillometry Equipment.

The application is to solve above-mentioned technical problem by the following technical programs.

A kind of eyepiece formula pupillary light reflex automatic checkout equipment, including

Camera, for obtaining eye image；

Polished bard stimulus provides at least one stimulating light source for user；

Distance measurement sensor, the distance for measuring camera to human eye；

And to the image analysis module of pupil progress completion and according to the pupil after the numerical value of distance measurement sensor and completion The data analysis module of image acquisition pupil data；

The signal output end of the camera and the signal input part of image analysis module communicate to connect, the letter of distance measurement sensor Number output end and data analysis module signal input part communicate to connect, and the signal output end and data of image analysis module analyze mould The signal input part of block communicates to connect.

Preferably, the method that described image analysis module carries out completion to pupil are as follows:

Step A: obtaining image, extracts pupil edge, judges whether pupil is blocked；If pupil is blocked, go to step B, otherwise go to step E；

Step B: the center of circle of circle and radius where taking up an official post and three pixels is taken to calculate pupil at pupil edge, the step for repetition, Until all pixels point on traversal pupil edge；

Step C: minimum two journey methods are carried out to all centers of circle obtained in step B and radius and are fitted to obtain the center of circle of fitting circle and half Diameter；

Step D: variance analysis is carried out to fitting circle and pupil edge, judges whether fitting precision meets the requirements, if fitting precision It is unsatisfactory for requiring, adjusts fitting parameter, go to step C；If fitting precision is met the requirements, go to step E；

Step E: pupil edge data are transferred to data analysis module.

Preferably, when fitting circle and the variance confidence level at pupil edge are greater than 0.95, fitting precision is met the requirements.

Preferably, if in step A pupil point set envelope region area < 100 pixel, judge that pupil is blocked；It is no Then judge that pupil is not blocked.

Preferably, the pupil data that the data analysis module obtains includes the incubation period of pupil change procedure, stablizes directly Peak acceleration and maximum speed when diameter, minimum diameter, pupil contraction.

Preferably, the method that the data analysis module obtains pupil data are as follows:

Step 1: setting filtering parameter is filtered the pupil data of complete stimulating course, putting down when calculating normal condition Minimum diameter when steady diameter and pupil minimum；

Step 2: to two o'clock corresponding on consecutive image, calculating speed and acceleration traverse all diameters of entire stimulating course Data obtain maximum speed and peak acceleration that pupil stress change；If there is continuously speed is greater than 10mm/s's three times Point, the then time started for stress reaction record the position data；

Step 3: output pupil data.

It preferably, further include parameter setting module and single-chip microcontroller, the signal input part and parameter setting mould of the single-chip microcontroller The signal output end of block, camera and distance measurement sensor communicates to connect, the signal output end and polished bard stimulus, image of single-chip microcontroller The communication connection of the signal input part of analysis module and data analysis module；It can be sent out as single-chip microcontroller by the parameter setting module Instruction changes luminous intensity, time and the frequency that polished bard stimulus generates out.

Preferably, the polished bard stimulus further includes three groups of optical filters of red, green, blue；The pupil detection equipment further includes red Outer light compensating lamp and the half-reflecting half mirror that the light of infrared light compensating lamp is reflected into pupil region, when pupil faces front, half anti-half The normal direction and sight angle of lens are in 30 ~ 60 °, a length of 850 ~ 940nm of infrared waves that infrared light compensating lamp issues.

It preferably, further include the Sound stimulat source of signal input part and the communication connection of single-chip microcomputer signal output end, the sound thorn Stimulus can issue stimulation sound source according to the instruction of parameter setting module.

Preferably, described image analysis module, data analysis module and parameter setting module are integrated in computer software, The computer software is computer software or cell phone software or embedded software or webpage.

The present invention provides a kind of the advantages of eyepiece formula pupillary light reflex automatic checkout equipment and is: based on eyepiece, It is easy to carry, compatible good；Various light sources and sound source are provided, convenient for selection stimulus type, darkroom is met by semi reflective mirror It is required that light filling is carried out to pupil by infrared light compensating lamp, convenient for obtaining clear image；By distance measurement sensor, accurately obtain It takes pupil at a distance from detection device, eliminates error；By completion algorithm, pupil data can be accurately extracted, light is reflected each Item objective parameter is very suitable to neurology department, ophthalmology and psychiatric department clinic and scientific research needs.

Detailed description of the invention

Fig. 1 is the composition schematic diagram of pupil detection equipment provided by the embodiment of the present invention.

Specific embodiment

As shown in Figure 1, a kind of eyepiece formula pupillary light reflex automatic checkout equipment, including the phase for obtaining eye image Machine 1, the polished bard stimulus 2 that stimulating light source is provided for user, measurement camera 1 to human eye relative distance distance measurement sensor 3, And to the image analysis module 41 of pupil image progress completion and according to the figure after the numerical value of distance measurement sensor 3 and completion Data analysis module 42 as obtaining pupil data；When in use, it will test equipment to be placed in front of human eye, enable the camera lens of camera 1 It is directed at pupil, emitting beam by polished bard stimulus 2 stimulates human eye, and camera 1 records the change procedure of pupil and sends an image to Image analysis module 41, image analysis module 41 are sent to data analysis module after carrying out completion to incomplete pupil image 42, at the same distance measurement sensor 3 by collected data transmission to data analysis module 42, range measurement in preferred embodiment Sensor 3 select infrared sensor ranging, the data directly obtained be the distance between distance measurement sensor 3 and pupil, Due to camera 1 and distance measurement sensor 3 relative position it has been determined that can use pupil and distance measurement sensor 3 it Between relative distance calculate the distance between pupil and camera 1；Then pupil is obtained by the image after the distance and completion The data in hole.

By introducing distance-measurement module 3, can be determined respectively for different users pupil and camera 1 it is opposite away from From raising measure data precision；In preferred embodiment, the camera 1 selects infrared camera to improve image quality.

Further, pupil detection equipment provided in this embodiment also has Sound stimulat source 6, in order to study sonic stimulation Influence to pupil contraction.In order to probe into influence of the light to pupil contraction of different colours, the polished bard stimulus 2 can be used can Alternating light selects luminescent color as needed；Optical filter, the optical filter can also be set between polished bard stimulus 2 and pupil Including three groups of red, green, blue, so as to provide the light of red, green, blue, Bai Si kind color for user, if you need to other colors, choosing With the combination of corresponding optical filter or multiple optical filters.

In order to further increase the image quality of camera 1, the pupil detection equipment further includes that (figure is not for infrared light compensating lamp Show) and the light of infrared light compensating lamp is reflected into the half-reflecting half mirror (not shown) of pupil region, when pupil faces front, half is anti- The normal direction and sight angle of pellicle mirror are in 30 ~ 60 °, preferably 45 °；It is 850 ~ 940nm's that the infrared light compensating lamp, which provides wavelength, Infrared light.

The pupil detection equipment further includes parameter setting module 43 and single-chip microcontroller 5, the signal input part of the single-chip microcontroller 5 It is communicated to connect with the signal output end of parameter setting module 43, camera 1 and distance measurement sensor 3, the signal output of single-chip microcontroller 5 End and the signal input part of polished bard stimulus 2, Sound stimulat source 6, image analysis module 41 and data analysis module 42 communicate to connect, figure As the signal output end of analysis module 41 and the signal input part of data analysis module 42 communicate to connect.The parameter setting module 43 issue instructions to single-chip microcontroller 5, single-chip microcontroller 5 according to the switch and luminous intensity of instruction control 2 harmony stimulus 6 of polished bard stimulus, when Between, frequency and corresponding audio parameter.

Described image analysis module 41 to pupil carry out completion method the following steps are included:

Step A: obtaining image, pupil edge is extracted, if area < 100 pixel in pupil point set envelope region, then it is assumed that pupil It is blocked, go to step B, and otherwise go to step E；

Step B: the center of circle of circle and radius where taking up an official post and three pixels is taken to calculate pupil at pupil edge, the step for repetition, Until all pixels point on traversal pupil edge；

Step C: minimum two journey methods are carried out to all centers of circle obtained in step B and radius and are fitted to obtain the center of circle of fitting circle and half Diameter；

Step D: variance analysis is carried out to fitting circle and pupil edge, judges whether fitting precision meets the requirements, if fitting precision It is unsatisfactory for requiring, adjusts fitting parameter, go to step C；If fitting precision is met the requirements, go to step E；

Step E: pupil edge data are transferred to data analysis module.

Wherein, when fitting circle and the variance confidence level at pupil edge are greater than 0.95, it is believed that fitting precision is met the requirements.

The pupil data that data analysis module 42 obtains includes incubation period of pupil change procedure, stable diameter, minimum straight Peak acceleration and maximum speed when diameter, pupil contraction etc., the method that data analysis module 42 obtains above-mentioned data are as follows:

Step 1: setting filtering parameter is filtered the pupil data of complete stimulating course, putting down when calculating normal condition Minimum diameter when steady diameter and pupil minimum；

Step 2: to two o'clock corresponding on consecutive image, calculating speed and acceleration traverse all diameters of entire stimulating course Data obtain maximum speed and peak acceleration that pupil stress change；If there is continuously speed is greater than 10 mm/s' three times Point, the then time started for stress reaction record the position data；Start by comparing the time and stress reaction that provide stimulation Time available pupil stress reaction incubation period；

Step 3: output pupil data.

Described image analysis module 41, data analysis module 42 and parameter setting module 43 can be write with conventional controller Enter related algorithm to realize corresponding function, they can also be integrated in computer software, by calling electronic equipment certainly The processor of body is handled；The computer software is computer software or cell phone software or embedded software or webpage.