阅读说明：本技术 制造眼部植入物输送装置的方法 (The method for manufacturing ocular implants conveying device ) 是由 查尔斯·雷蒙德·小卡利娜 巴里·林恩·惠特利 加里·兰热尔-费里德曼 于 2019-09-12 设计创作，主要内容包括：本公开公开了一种制造可输送多个眼内植入物的装置的方法,包括：将第一壳体部分放置在工件保持器的定心销上,使得定心销延伸穿过第一壳体部分；将锤凸轮放置在定心销上,使第一壳体部分设置在锤凸轮和工件保持器之间；将夹头保持器安置在第一壳体部分上,使夹头保持器的夹头从动件与锤凸轮的凸轮表面直接接触；将管组件的夹头固定到夹头保持器；将管组件的套管针固定到第一壳体部分；将管组件的插入管固定到第一壳体部分；将第二壳体部分紧固到第一壳体部分以形成外部壳体；以及从工件保持器移除外部壳体。本公开的方法使得可以在不从眼睛移除输送装置的情况下将各个植入物输送到眼睛内的不同位置处,精确度提高且降低了制造成本。(The present disclosure discloses a kind of methods for manufacturing and can transport the device of multiple intraocular implants, comprising: first shell is partially disposed on the centring pin of Workpiece Holders, so that centring pin extends through first shell part；Process of malleus wheel is placed on centring pin, first shell part is set between process of malleus wheel and Workpiece Holders；Collet retainer is placed on first shell part, contacts the collet driven member of collet retainer directly with the cam face of process of malleus wheel；The collet of tube assembly is fixed to collet retainer；The trochar of tube assembly is fixed to first shell part；The insertion tube of tube assembly is fixed to first shell part；Second shell part is fastened to first shell part to form external shell；And external shell is removed from Workpiece Holders.At the different location that disclosed method allows to that each implantation material is transported in eyes in the case where not removing conveying device from eyes, accuracy improves and reduces manufacturing cost.)

1. a kind of method that manufacture can convey the device of multiple intraocular implants, which comprises

First shell is partially disposed on the centring pin of Workpiece Holders, so that the centring pin extends through the first shell Body portion；

Process of malleus wheel is placed on the centring pin, the first shell part setting is kept in the process of malleus wheel and the workpiece Between device；

Collet retainer is placed on the first shell part so that the collet driven member of the collet retainer with it is described The cam face of process of malleus wheel directly contacts；

The collet of tube assembly is fixed to the collet retainer；

The trochar of the tube assembly is fixed to the first shell part；

The insertion tube of the tube assembly is fixed to the first shell part；

Second shell part is fastened to the first shell part to form external shell；And

The external shell is removed from the Workpiece Holders.

2. according to the method described in claim 1, further comprising being located so that the implantation material being arranged in the collet The distal end of the implantation material is flushed with the distal end of the collet, wherein described sleeve pipe needle is being fixed to described the Positioning implants are executed before one housing parts.

3. according to the method described in claim 2, wherein, positioning implants include grasped with locator tool described sleeve pipe needle with And with the locator tool relative to the mobile described sleeve pipe needle of the collet.

4. according to the method described in claim 2, further comprise make implantation material relative to the collet deviate an offset distance, Wherein, offset is executed after positioning the implantation material.

5. according to the method described in claim 4, wherein, after deviating implantation material, the distal end quilt of the implantation material It is arranged to distad exceed the distal end of the collet.

6. according to the method described in claim 4, wherein, after deviating implantation material, the distal end of the collet is set It is set to the distal end for distad exceeding the implantation material.

7. according to the method described in claim 1, wherein, fixed described sleeve pipe needle includes that described sleeve pipe needle is integrated to described the The well of one housing parts.

8. according to the method described in claim 7, wherein, described sleeve pipe needle is integrated to the well using adhesive.

9. according to the method described in claim 8, wherein, the well is cylindrical, and combining and being included in described sleeve pipe Needle alignment adds binder to the well to extend along the diameter of the well later.

10. according to the method described in claim 1, further comprise the collet retainer and the first shell part it Between load collet reset spring so that the collet reset spring press collet driven member against the process of malleus wheel CAM table Face.

11. according to the method described in claim 1, wherein, the fixed insertion tube include the insertion tube is integrated to it is described The boss of first shell part.

12. according to the method for claim 11, wherein the boss is cylindrical, and will be described in conjunction with being included in Insertion tube alignment adds binder to the boss to extend along the diameter of the boss later.

13. according to the method described in claim 1, further comprise position insertion tube make the distal end of the insertion tube with The distal end of the collet flushes, wherein executes positioning before the insertion tube is fixed to the first shell part The insertion tube.

14. according to the method for claim 13, further comprising keeping the insertion tube inclined relative to collet offset one Move distance, wherein execute offset after positioning the insertion tube.

15. according to the method for claim 14, wherein after deviating the insertion tube, the distal side of the insertion tube End is configured to distad exceed the distal end of the collet.

16. according to the method for claim 14, wherein the insertion tube is made to deviate the offset distance relative to the collet From the conveying distance of bracket has been determined.

17. according to the method described in claim 1, wherein, pin gap between the centring pin and the process of malleus wheel at 5 μm and Between 75 μm.

18. according to the method described in claim 4, wherein, the offset distance is between 0.00762mm and 0.0254mm.

19. according to the method described in claim 1, further comprising making the Workpiece Holders along transmission device from the first work Make station and is moved to second work station.

20. according to the method described in claim 1, wherein, from the Workpiece Holders remove the external shell include along The first shell part is moved far from the Workpiece Holders in the direction for being parallel to the longitudinal axis of the centring pin.

Technical field

The disclosure relates generally to implantation material is transported to the device that eye disease (such as glaucoma) is treated in eyes And the manufacture of this device.In some respects, the method for manufacturing the device that can transport multiple intraocular implants is disclosed.

Background technique

Intraocular implant (for example, current divider or bracket) can be implanted into the outflow in eyes in order to aqueous humor, to drop Low intraocular pressure.Method and system for multiple implantation materials to be transported in same eyes is usually required to remove from eyes and be conveyed Instrument and make its second implantation material of reloading.This process of reloading increases operating time, increases due to exposure With infection risk caused by the excess processes to implantation material, and due in notch it is multiple entrance and increase to eye injuries Risk.

Summary of the invention

Need a kind of milder multiple implantation materials being transported in eyes, more convenient, smaller invasive and smaller wound The mode of property.In some embodiments of the present disclosure, manufacture is provided for multiple ocular implants to be transported to internal eye group Needing at multiple implantation positions in knitting while only the method for the system of the single notch in external ocular tissue.

Several embodiments of the invention have the following advantages that in it is one or more: (i) conveys multiple one at a time Stacked implantation material, without allowing unintentionally to convey multiple implantation materials simultaneously；(ii) tighter tolerances between holding member, in order to avoid Increase the overall dimensions of conveying device；(iii) each implantation material is transported in the case where not removing conveying device from eyes At different location in eyes；(iv) accuracy improves；(v) glaucoma is treated；(vi) by during the assembling of device feature Engineering tolerances are considered to reduce manufacturing cost；(vii) it is dropped by the accuracy of the raising of the collet positioned relative to implantation material Low implantation material size；And/or the quantity of multiple implantation materials that (viii) is loaded in conveying device increases.

In some respects, this disclosure relates to which a kind of manufacture the method that can transport the device of multiple intraocular implants, the side Method includes: that first shell is partially disposed on the centring pin of Workpiece Holders, so that the centring pin extends through described One housing parts.The method further includes: process of malleus wheel is placed on the centring pin, the first shell part setting Between the process of malleus wheel and the Workpiece Holders.The method further includes: collet retainer is placed in described On one housing parts, so that the collet driven member of the collet retainer is directly contacted with the cam face of the process of malleus wheel.Institute The method of stating further comprises: the collet of tube assembly is fixed to collet retainer；The trochar of the tube assembly is fixed to institute State first shell part；And the insertion tube of the tube assembly is fixed to the first shell part.The method is further It include: that second shell part is fastened to the first shell part to form external shell；And from the Workpiece Holders Remove the external shell.

In some respects, the method may further include: the implantation material being arranged in the collet is positioned to make The distal end for obtaining the implantation material is flushed with the distal end of the collet, and wherein positioning implants are fixed to by trochar It is executed before the first shell part.In some respects, positioning implants may include with locator tool grasp trochar with And with the locator tool relative to the mobile described sleeve pipe needle of the collet.In some respects, the method can be wrapped further It includes: so that implantation material is deviated an offset distance relative to the collet, wherein executing offset after positioning implants.In some sides Face, the method can include: after deviating implantation material, the distal end of implantation material is arranged to distad beyond the collet Distal end.In some respects, the method can include: after deviating implantation material, the distal end of the collet is set It is set to the distal end for distad exceeding implantation material.In some respects, fixed described sleeve pipe needle may include being integrated to trochar In the well of the first shell part.In some respects, described sleeve pipe needle is integrated to the well using adhesive.In some sides Face, the well can be it is cylindrical, and in conjunction with may include being prolonged with the diameter along the well being aligned described sleeve pipe needle The well is added binder to after stretching.In some respects, the method can further comprise: collet reset spring is loaded Between collet retainer and the first shell part, so that the collet reset spring presses collet driven member against described The cam face of process of malleus wheel.In some respects, the fixed insertion tube may include that the insertion tube is integrated to the first shell The boss of body portion.In some respects, the boss can be cylindrical, and in conjunction with may include by the insertion tube pair Standard adds binder to the boss to extend along the diameter of the boss later.In some respects, the method can be into One step include: insertion tube is located so that the distal end of the insertion tube is flushed with the distal end of the collet, wherein It is executed before the insertion tube is fixed to the first shell part and positions the insertion tube.In some respects, the side Method can further comprise: so that the insertion tube is deviated an offset distance relative to the collet, wherein positioning the insertion tube Offset is executed later.In some respects, after deviating the insertion tube, the distal end of the insertion tube is arranged to remote Side exceeds the distal end of the collet.In some respects, the insertion tube is made to deviate the offset distance relative to the collet From the conveying distance of the bracket has been determined.In some respects, the pin gap between the centring pin and the process of malleus wheel can be with Between 5 μm and 75 μm.In some respects, offset distance can be between 0.00762mm and 0.0254mm.In some respects, The method can further comprise: the Workpiece Holders being made to be moved to the second work from first work station along transmission device It stands.In some respects, removing the external shell from the Workpiece Holders may include along being parallel to the vertical of the centring pin The first shell part is moved far from the Workpiece Holders to the direction of axis.

Detailed description of the invention

These and other feature of the disclosure, aspect and excellent are described referring now to the attached drawing of the embodiment of the present invention Point, these embodiments are intended to show that rather than limit the scope of the present disclosure.

Fig. 1 is the perspective view for showing the embodiment of more intraocular implant conveying devices.

Fig. 2 is the longitdinal cross-section diagram at the needle end of more intraocular implant conveying devices of Fig. 1, and it illustrates prepare the more of conveying A ocular implants.

Fig. 3 A shows the distal end of more intraocular implant conveying devices before conveying the first intraocular implant Sectional view.

Fig. 3 B show retracted in collet with separate farthest side implantation material so as to Fig. 3 A after conveying conveying dress It sets.

Fig. 3 C, which is shown, to be pushed along trochar by farthest side implantation material in collet and enters Fig. 3 A's after ocular tissue Conveying device.

Fig. 4 is the top view of the conveying device in partially assembled state.

Fig. 5 shows the embodiment of the assembly line for assembling more intraocular implant conveying devices.

Fig. 6 shows the loading plate for the transfer device between the work station of assembly line.

Fig. 7 shows the right shell body of conveying device being arranged on the centring pin of Workpiece Holders.

Fig. 8 shows the embodiment of the conveying device in partially assembled state, and wherein process of malleus wheel is arranged to the shell of device On body portion.

Fig. 9 shows the embodiment of the conveying device in partially assembled state, and intermediate tube assembly is arranged to the shell of device On body portion.

Figure 10 shows tube assembly the putting to the position of the collet retainer for tube assembly to be attached to device of device It sets.

Figure 11 shows locator tool, is used to before collet is attached to collet retainer adjust the position of collet It sets.

Figure 12 shows the top view of collet, and collet is held and locate by locator tool for collet to be attached to folder Head retainer.

Figure 13 A shows more Vitreous cavities before locator tool has been used for adjusting position of the implantation material in collet The distal end of object conveying device.

Figure 13 B shows the more of Figure 13 A after locator tool has been used for position of the adjusting implantation material in collet The distal end of intraocular implant conveying device.

Figure 13 C is shown after locator tool has made farthest side implantation material be moved to and flush with the distal end of collet More intraocular implant conveying devices distal end sectional view.

Figure 14 shows the top view that the collet of well of collet retainer is integrated to by adhesive.

Figure 15 shows the locator tool for getting out the insertion tube of grasping tube assembly.

Figure 16 is shown has made insertion tube be moved to more after flushing with the distal end of collet in locator tool The sectional view of the distal end of implant conveying device.

Figure 17 shows the top view of insertion tube, the insertion tube by adhesive be integrated to setting it is defeated in more intraocular implants Send the boss on the shell of device.

Figure 18 shows the embodiment of the bedding for being inserted into tube assembly in insertion sleeve.

Figure 19 shows the embodiment of the conveying device in partially assembled state, wherein insertion sleeve is installed to device In tube assembly.

Figure 20 shows the embodiment of the conveying device in partially assembled state, wherein insertion sleeve button connecting rod installation Onto the shell of device.

Figure 21 shows the embodiment of the conveying device in partially assembled state, and middle sleeve retract button is installed to dress On the shell set.

Figure 22 shows the embodiment of the conveying device in partially assembled state, wherein insertion sleeve button connecting rod positioning At the button connecting rod harness for being connected to insertion sleeve.

Figure 23 shows the embodiment of the buckle fixed link of the right shell body for left shell to be fastened to conveying device.

Figure 24 is shown after left shell and right shell body are already fixed to together, and what is removed from Workpiece Holders is mostly intraocular The embodiment of implantation material conveying device.

Specific embodiment

Method this document describes manufacture for conveying the high-precision device of multiple ocular implants.In the following description, Numerous specific details are set forth to provide a thorough understanding of the embodiments；However, those skilled in the relevant art will be based on this Text disclosure recognize, can in the case where detail described in none or more, or otherwise, Component, material etc. practice technique described herein.In other cases, be not shown or described in detail well-known structure, Material or operation are to avoid fuzzy some aspects.

Fig. 1 is the perspective view of the non-restrictive illustrative embodiment of conveying equipment 100, and the conveying equipment 100 is constructed It is transported in the ocular tissue of patient at by multiple intraocular implants.For brevity, it will assemble

The manufacturing method of the disclosure of described in the text up and down of more implantation material conveying equipments 100 shown in Fig. 1.However, this The method that text provides can be used for manufacturing other implantation material transportation systems, including but not limited to non-ocular implants transportation system and structure Cause the ocular implants transportation system (for example, non-more ocular implants transportation systems) for only conveying single ocular implants.

As shown in fig. 1, more implantation material conveying equipments 100 may include external shell 102, and external shell 102 includes remote Side end 105 and proximal end 106, main body extend between distal end 105 and proximal end 106.External shell 102 can be with Including right shell body 101 and left shell 103, the two tightens together to form external shell 102.In the shown embodiment, distal side End 105 is tapered to form nose cone 104, and insertion sleeve 108 extends from nose cone 104.Being inserted into sleeve may include needle.Such as figure Shown, the proximal end 106 of more implantation material conveying equipments 100 can also be tapered and can optionally include marking plate 110, external shell 102 for example can be fixed to by engaging, gluing, welding or other combination methods.External shell 102 into One step includes that button openings 112, sleeve retract button 114 and trigger button 116 are prominent from button openings 112, for by making User's actuating, as described herein.

More implantation material conveying equipments 100 are shaped so as to grasp and manipulate with advantageously meeting ergonomics, and have There is the general global shape for being similar to traditional writing instrument (such as pen).In one embodiment, more implantation material conveying equipments 100 can be grasped between thumb and middle finger by user, wherein index finger freely engages sleeve retract button 114 and triggering is pressed Button 116.In certain embodiments, more implantation material conveying equipments 100 can grasped to provide for user on external shell 102 Tactile ridge (not shown) is set at the position of stronger grasping.

Fig. 2 shows the longitdinal cross-section diagrams of the distal end of the insertion sleeve 108 of more implantation material conveying equipments 100.Such as figure It is shown, multiple ocular implants 200 can be pre-loaded onto trochar 120 or on.More implantation material conveying equipments 100 can be used for The multiple ocular implants 200 are transported to the intraocular multiple desired locations of mammal (for example, people).For example, insertion Sleeve 108 can be advanced through preformed notch or opening in eyes.In another embodiment, insertion sleeve 108 can To travel across external ocular tissue (for example, cornea, corneal limbus and/or sclera), to be generated when it is advanced in ocular tissue Pass through the notch or opening of eyes.

Trigger button 116 (Fig. 1) presses the more implantation material conveying equipments 100 of actuating and conveys the first implantation material 200 Required first position in patient's internal eye tissues.In one embodiment, more implantation material conveyings can then be relocated Second implantation material 200 can be transported between first position by equipment 100 without removing insertion sleeve 108 from notch The second position separated.In another embodiment, insertion sleeve 108 can remove from notch and pass through separated notch inserts again Enter through ocular tissue, so that the second implantation material 200 is transported to the second implant site.According to several embodiments, the multiple eye The conveying of portion's implantation material executes advantageously during outpatient operation without largely performing the operation.

The combination of entire external shell shape and sleeve retract button 114 and the certain position of trigger button 116, allows User is mainly controlled the positioning of insertion sleeve 108 by the manipulation of thumb and middle finger and keeps its stability.Index finger is simultaneously The actuating of more implantation material conveying equipments 100 is controlled, and therefore controls multiple desired locations of these implantation materials 200 in eyes Implantation.The design effectively separates location control and actuation control, so that reducing conveying implantation material can cause unintentionally More implantation material conveying equipments 100 are mobile and make the practical placement of implantation material not in the risk of desired locations.

With continued reference to Fig. 2, during the assembling of conveying equipment 100, four ocular implants 200 can be pre-loaded onto casing On needle 120.In some embodiments, more implantation material conveying equipments 100 can receive more or less than four implantation materials 200 to plant Enter into internal eye tissues.In certain embodiments, these ocular implants 200 along trochar 120 longitudinal axis sequence Ground setting (for example, arranging in tandem).In various embodiments, in assembling, trochar 120 is maintained in collet 122. In some embodiments, trochar 120 can vertically move in collet 122.In other embodiments, trochar 120 is opposite It is fixed in collet 122.In various embodiments, in assembling, collet 122 is contained in insertion tube 124, and insertion tube 124 can phase It is fixed for trochar 120.Insertion tube 124 can advantageously comprise the hollow hypodermic tube being made of stainless steel.It is substituting In embodiment, insertion tube 124 can be made of any rigid material (such as metal, plastics or polymer).Insertion tube 124 it is interior straight The range of diameter can be in about 0.125mm to about 2mm, about 0.25mm to about 0.75mm, about 0.38mm to about 0.50mm or its overlapping model In enclosing.Entitled " the SYSTEM AND METHOD FOR that the additional detail of conveying device can be authorized on January 31st, 2017 It is found in the United States Patent (USP) 9,554,940 of DELIVERING MULTIPLE OCULAR IMPLANTS ", the disclosure of which passes through Reference is integrally incorporated herein.

Fig. 3 A- Fig. 3 C shows conveying of the first implantation material 200A at the first expectation implant site.Fig. 3 A is shown The initial initial position of the distal end of collet 122 before user's first time pressing trigger button 116.As shown, casing Needle 120 travels across trabecular network 10 at desired implant site.In the shown embodiment, implantation material 200A-200D along The longitudinal axis of trochar 120 is arranged in tandem.Each of implantation material 200A-200D includes interior lumen, trochar 120 at least part extends through interior lumen.The initial seed point of the distal end of collet 122 corresponds to the first implantation material The front end of 200A, and can be spaced apart with the distal end of trochar 120.

As discussed herein, the first implantation material 200A can be in the manufacture of conveying device 100 relative to the position of collet 122 Or it is set during assembling.In some respects, methods herein allows implantation material 200 to be set relative to the initial position of collet 122 It is set to all parts (for example, implantation material 200, trochar 120, collet 122, external shell 102) independently of conveying device 100 Engineering tolerances.As used herein term " engineering tolerances " is broad terms, is intended to include in numerous similar products The change in size occurred in manufacturing process.In figure 3 a, for the sake of clarity, the distal end 123 of collet 122 is shown as and the The distal end 223 of one implantation material 200A is slightly spaced.In some embodiments, the distal end 123 of collet 122 can be with The distal end 223 of one implantation material 200A flushes.In some embodiments, the distal end 123 of collet 122 can be in device 100 Original position be arranged in the first implantation material 200 distal end 223 nearside or distal side, the initial position quilt of device 100 It is defined as tightly being pressed in the trigger button 116 of device 100 with the position before the conveying of the first implantation material 200A of actuating.In In some embodiments, by relative to 200 movable chuck 122 of implantation material being loaded on trochar 120, in device 100 The initial position of the first implantation material 200A is set during assembling, as discussed herein.

Fig. 3 B, which is shown, has been retracted to first in the distal end that user has pressed trigger button 116 and collet 122 The distal end of collet 122 after position between the proximal end of implantation material 200A and the distal end of the second implantation material 200B Position.At point B, collet 122 engages the proximal end of the first implantation material 200A, to be effectively isolated or " separation " first Implantation material 200A is for conveying.Fig. 3 C is shown when the first implantation material 200A is implanted due to the driving force of collet 122 And rest upon the position of the distal end of collet 122 when in the expectation implant site across trabecular network 10 securely now.

As shown in Figure 3B, in order to which implantation material 200 to be separated from each other, initial position of the collet 122 relative to implantation material 200 Must be accurate enough with movement, so that the distal end 123 of collet 122 is longitudinally landed in setting along trochar 120 the In touch-down zone 125 between the proximal end of one implantation material 200A and the distal end of the second implantation material 200B.Although it is not shown, But the second touch-down zone 125 can be limited to the proximal end of the second implantation material 200B and the distal end of third implantation material 200C Between, third touch-down zone 125 can be limited to the proximal end of third implantation material 200C and the distal end portion of the 4th implantation material 200D Between portion, and the 4th touch-down zone 125 can be limited near the proximal end of the 4th implantation material 200D.The distal side of collet 122 End 123 will land convey the second implantation material 200B in the second touch-down zone 125, and landing conveys the in third touch-down zone Three implantation material 200C, and land in the 4th touch-down zone to convey the 4th implantation material 200D.It is including being more than four implantation materials In 200 embodiment, this mode of touch-down zone 125 and implantation material 200 will continue along trochar 120 to nearside.

In some embodiments, the longitudinal length of implantation material 200 can be between about 300 μm and 400 μm, and implantation material 200 can be stacked close to each other on trochar 120, so that the longitudinal length in touch-down zone 125 is much smaller than implantation material 200 itself. For example, in some embodiments, collet 122 must be configured to land in the touch-down zone 125 with about 5 μm of longitudinal length, So that conveying device 100 conveys multiple implantation materials as shown in Fig. 3 A- Fig. 3 C.In some embodiments, system disclosed herein The method of making provides a kind of ocular implants conveying device 100, can be advantageous by the distal end 123 for making collet 122 Landing has the longitudinal length between about 20 μm and 1000 μm, 50 μm and 500 μm, 75 μm and 200 μm, 100 μm and 150 μm Touch-down zone 125 in and from multiple stacked implantation materials separate implantation material 200.In one embodiment, touch-down zone 125 has There is 135 μm of maximum longitudinal length.In some embodiments, conveying device 100 is configured to that collet 122 is made to land in four differences Touch-down zone in (as described above), to separate each of four implantation materials 200 for being sequentially arranged with each other.In some implementations In example, conveying device 100 keeps two implantation materials 200 just, and is configured to land in two different touch-down zones just Collet 122, to separate each of the two implantation materials 200, the two implantation materials 200 are every in implantation material 200 It is sequentially arranged with each other on the trochar 120 of a central lumen.

In some respects, manufacturing method disclosed herein allows during the assembling of device 100 " dial-out " or adjusts defeated The engineering tolerances of each movable part of device 100 are sent, so that these tolerances will not be superposed on one another.If not preventing engineering public Difference is superposed on one another, then must reduce each tolerance with the total effect for ensuring these tolerances and still allow for the distal end portion of collet 122 It lands in the touch-down zone 125 between about 20 μm and 1000 μm in portion 123.For in the different piece of conveying device 100 Each individually reducing tolerance can make the manufacture of conveying device 100 prohibitively expensive.In contrast, manufacturing method disclosed herein It can be by avoiding that tolerance is summed it up to the manufacturing cost for reducing device 100 together during the assembling of device 100.In some sides Face, method disclosed herein generate more implantation material conveying devices 100, can more reliably convey multiple stacked implantation materials.Such as The conveying device 100 of assembling described herein can provide the more repeatable and accurate movement of collet 122, to allow conveying device Multiple small implantation materials that 100 separation are aligned in tandem closely to each other.The tolerance provided by this assemble method " is dialled Generation can reliably land the distal end of collet 122 defeated in the touch-down zone of narrow (for example, length is less than 135 μm) out " Send device 100.

Fig. 4 shows the top view that can be used for manufacturing or assembling the embodiment of Workpiece Holders 300 of conveying device 100. Workpiece Holders 300 may be configured to that conveying device 100 is maintained at relative to workbench or work during the assembling of device 100 The fixation position stood.In Fig. 4, conveying device 100 is illustrated at partly assembled state.As shown, the right side of device 100 Shell 101 can be placed in Workpiece Holders 300.Workpiece Holders 300 have centring pin 302 (Fig. 7), keep from workpiece The top surface of device 300 extends vertically.As described herein, centring pin 302 can provide reference point, in assembling conveying device The position of other components of device 100 is limited during 100.

As shown in Figure 4, the process of malleus wheel 140 of conveying device 100 can be arranged on centring pin 302, so that centring pin 302 Across the rotation axis of process of malleus wheel 140 and aligned therewith.During the use of device 100, process of malleus wheel 140 be it is spring-loaded simultaneously And it is configured to rotate about a part of axis rotation revolution once trigger button 116 is pressed.The rotation of process of malleus wheel 140 is driven Dynamic collet retainer 150 is mobile in a manner of longitudinal movement back and forth.Collet retainer 150 is fixed to collet 122, so that process of malleus wheel 140 rotation can drive collet 122 to vertically move along trochar 120, with the conveying as described in above for Fig. 3 A- Fig. 3 C Implantation material 200.

With continued reference to Fig. 4, Workpiece Holders 300 can have multiple rigid posts 304, from the top table of Workpiece Holders 300 Face extends.Rigid post 304 may be disposed to the movement of constraint workpiece (for example, right shell body 101), so that workpiece is kept relative to workpiece Device 300 is fixed.In some respects, column 304 can assist alignment second workpiece (for example, left shell 103) so that second workpiece is appropriate It disposes and is attached on right shell body 101.In some respects, column 304 can prevent left shell 103 from shifting during assembly.Some Aspect, column 304 can prevent misalignment of the process of malleus wheel bore between right shell body 101 and left shell 103, to prevent collet retainer 150 move during assembly and subsequently result in backing positions and change during assembly.Work station can have fixture 160, folder Tool 160 synergistically works with rigid post 304, and workpiece is locked in place relative to Workpiece Holders 300.Work station may include lock Determine tower arm 170.As discussed herein, locking tower arm 170 can be during the assembling of device 100 by one of device 100 or more Multiple components (for example, collet retainer 150) are held in place.In the shown embodiment, by by the internal part group of device 100 Carry out manufacturing device 100 in the right shell body 101 of device 100.It in right shell body 101 is mounted in the internal part of device 100 Afterwards, left shell 103 (Figure 21) can be fastened on right shell body 101, to complete the assembling of external shell 102 (Fig. 1).Some In embodiment, the internal part of device 100 be can be assembled on left shell 103, and then right shell body 101 can be fastened to left shell 103 On to complete the assembling of external shell 102.As shown, work station may include trigger button supporting pin 171, it is used to assemble Period support trigger button 116 simultaneously keeps alignment of the trigger button 116 between right shell body 101 and left shell 103.In shown reality It applies in example, trigger button supporting pin 171 slightly presses trigger button 116, so that the engagement right shell body 101 on trigger button 116 Institute will not be interfered during the assembling (for example, being fastened togather) of right shell body 101 and left shell 103 with the flange of left shell 103 State shell 101,103.

Fig. 5 shows the embodiment of the assembly line 500 for manufacturing conveying device 100.Assembly line 500 can have such as figure Shown three be arranged in juxtaposition different work station 502A, 502B, 502C.In some embodiments, assembly line 500 may include More than three work station 502 or only two work stations 502.In some embodiments, structure can be carried out using only a work station 502 Build or assemble conveying device 100.For example, conveying device 100 can construct at single discrete unit or work station 502 or group Dress, rather than use the assembly line of two or more work stations 502.In some embodiments, work station 502 may be disposed to that This forms closed loop rather than arranges side by side.In some embodiments, work station 502 can be configured in conveying device 100 Different tasks is executed in assembling.In some respects, there may be the single workpiece guarantors of the mobile assembly line by work station 502 Holder 300.In some respects, multiple Workpiece Holders 300 can simultaneously, concurrently and be separated from each other movement pass through The assembly line of work station.In some embodiments, the movement of one to eight Workpiece Holders 300 can passes through assembly line.Extremely In few one embodiment, there are four the movements of Workpiece Holders 300 to pass through assembly line.

It may include the track or transmission dress that another work station is extended to from a work station that Fig. 6, which shows assembly line 500, Set 504.For example, transmission device 504 can extend from first work station 500A referring briefly to Fig. 5, pass through second work station 500B, and extend to 3rd work station 500C.Fig. 6 is passed again to, Workpiece Holders 300 can couple by loading plate 506 To transmission device 504.Workpiece Holders 300 can be fixed relative to loading plate 506.Loading plate 506 can have locking reconciliation Lock structure.When loading plate 506 is in unlocking structure, loading plate 506 can move (for example, sliding) along transmission device 504.When When loading plate 506 is in locked configuration, loading plate 506 can be fixed relative to transmission device 504.In this way, transmission device 504 can make Workpiece is obtained to move and fix during the assembling process of device 100.

Fig. 7 shows the device 100 in assembling early stage.Right shell body 101 can be arranged on Workpiece Holders 300 And it is held in place by fixture 160.As shown, right shell body 101 may include the edge 107 for surrounding opening, the opening scale It is very little to pass through right shell body 101 from Workpiece Holders 300 at permission centring pin 302.Insertion sleeve retracts spring 109 and is shown attached to Right shell body 101.

Fig. 8 shows the device 100 after process of malleus wheel 140 is installed on right shell body 101.As shown, process of malleus wheel 140 may include the center hub 142 with cylindrical hole.In some embodiments, centring pin 302, which can be sized to have, is more than The longitudinal length of the longitudinal length of center hub 142 allows pin 302 to extend fully through the hole of center hub 142.In order to avoid When left shell 103 is attached to right shell body 101 damage centring pin 302, left shell 103 can shape shape be receiving centring pin 302 Extend beyond the part of center hub 142.In some respects, left shell 103 may include through-hole, when left shell 103 is attached to right shell When body 101, which receives and accommodates a part of one or two of centring pin 302 and center hub 142.In some implementations In example, left shell 103 does not include a part for being sized to accommodate one or two of centring pin 302 and center hub 142 Through-hole.In some embodiments, centring pin 302 is sized such that centring pin 302 does not extend out the left housing side of center hub 142 Opening.In some embodiments, centring pin 302 is flushed with the left shell side opening of center hub 142.In right shell body 101 and left housing After body 103 links, device 100 (including center hub 142) can be removed from Workpiece Holders 300, and centring pin 302 is made to stay in attachment To the position of Workpiece Holders 300.

Centring pin 302 can be sized in the hole for concentrically fitting in center hub 142.Centring pin 302 can have between pin Gap, the pin gap are defined as between the surface and centring pin 302 in the hole of center hub 142 extended through towards centring pin 302 Gap.In some embodiments, centring pin 302 can be sized to the pin gap with 50 μm.In some embodiments, fixed Heart pin 302 is sized to provide at 2 μm to 1000 μm, 5 μm to 500 μm, 5 μm to 75 μm, 10 μm to 200 μm, 20 μm to 100 μ M, the pin gap between 40 μm to 60 μm etc..

Position of the hole that centring pin 302 can be configured to accurately fix process of malleus wheel 140 relative to right shell body 101.Conveying The assembly precision of device 100 can allow device 100 will not significant ground shifting bracket with the attachment of left shell 103 to right shell body 101 100 assemble relative to the mode of the final position of collet 122.Centring pin 302 can be sized to allow process of malleus wheel 140 around centering Pin 302 rotates (for example, to wind the spring of process of malleus wheel 140).During the arranged concentric of center hub 142 and centring pin 302 can prevent Heart hub 142 is tilted relative to Workpiece Holders 300.In some embodiments, centring pin 302 may be configured to orient and keep process of malleus Wheel 140, so that center hub 142 is approximately perpendicular to Workpiece Holders 300.In some respects, centring pin 302 can position conveying dress Set all precision parts in 100.In this way, centring pin 302 is considered " world centre " reference point, it is fixed, makes The precision parts obtained in conveying device 100 accurately can be referred to or be positioned relative to centring pin 302.In some respects, it feels relieved The position of pin 302 is so important for the accurate assembling of conveying device 100, so that centring pin 302 can be by ceramics (for example, carbonization Silicon) it is made, to ensure that centring pin 302 is broken before the bend.The centring pin 302 of fracture is preferable over the centring pin 302 of bending, because For bending centring pin 302 will lead to conveying device 100 precision parts misalignment.The centring pin 302 or and shell of bending 101 centring pins 302 with too wide arc gap can significantly affect the scrappage (for example, increasing scrappage) of finished conveying device 100.

Fig. 9 shows the device 100 after collet retainer 150 is placed on right shell body 101.Tube assembly 180 It is shown as extending and exceeding the distal end 105 of right shell body 101 from collet retainer 150.Tube assembly 180 may include implantation material 200, trochar 120, collet 122 and insertion tube 124.Trochar 120 may be provided in collet 122.Implantation material 200 can be loaded into On trochar 120.Trochar 120 can extend across the central lumen of implantation material 200.As discussed herein, collet retainer 150 and tube assembly 180 can be mounted in the sub-component on right shell body 101.

Group shown in Fig. 9 decorates place, and the part of tube assembly 180 can be mobile relative to collet retainer 150, and tube assembly 180 other parts are fixed to collet retainer 150.Trochar 120 can also be mobile relative to collet 122 at this time.Such as this paper institute Description, then trochar 120 can be fixed on right shell body 101 relative to the position of 122 adjusting sleeve pipe needle 120 of collet. Tube assembly 180 and its component can be individually adjusted during the assembling of device 100 (for example, implantation material 200, trochar 120, folder First position 122), to reduce the variation of the final position of each component relative to each other in the assembling of finishing device 100.This Sample can pass through the opposite position of adjusting implantation material 200, trochar 120, collet 122 and insertion tube 124 as described herein It sets and is compensated come the engineering tolerances of the component to device 100.In some respects, tube assembly is adjusted during the assembling of device 100 180 and its position of component can eliminate the final position of as caused by the engineering tolerances of all parts of device 100 component Variation.

Figure 10, which shows locking tower arm 170 and a pair of of pliers 172, can be used for collet retainer 150 being placed in right shell body On 101 track 111.As shown, collet reset spring 152, which can compress, is placed on right shell body 101 and collet retainer 150 Between.152 pressable collet retainer 150 of collet reset spring is against process of malleus wheel 140.When process of malleus wheel 140 rotates, process of malleus wheel 140 cam face can drive collet retainer 150 to overcome the reaction force of reset spring 152, thus movable chuck 122 with Conveying implantation material 200 as described herein.Collet retainer 150 can be suspended at 101 top of shell and by locking tower arm Three holding screws 173 on 170 be appropriately positioned in +Z direction (for example, along centring pin 302 axis and towards locking tower The direction of arm 170) on.By promoting collet retainer 150 with pliers 172 as shown in the figure, collet retainer 150 can be in the side+Z It is properly located upwards.Collet retainer 150 can be by collet reset spring 152 and by collet retainer 150 and process of malleus wheel What 140 contact generated frictionally holds in place.

Tube assembly 180 can extend along the central axis of screw chuck reset spring 152.As shown, trochar 120 can It is proximally away from reset spring 152 and extends across the well 154 being arranged on right shell body 101.Insertion tube 124 can be far from reset bullet Spring 152 is distally extending and passes through the boss 156 being arranged on right shell body 101.Well 154 and boss 156 can respectively have and make The groove that insertion tube 124 and trochar 120 are aligned with the diameter of boss 156 and well 154 respectively.In the shown embodiment, it is inserted into The proximal end of pipe 124 is located near the distal end of reset spring 152.Collet 122 can be seen by the gap of reset spring 152 It arrives, and is shown as extening proximally to the distal end far from reset spring 152.The proximal end of collet 122 is attached to folder The distal face of head retainer 150, and trochar 120 can be seen and extend proximally over the distal face of collet retainer 150 simultaneously And cross the diameter of well 154.As described herein, the insertion sleeve 124 (Fig. 2) of tube assembly 180 can fix (for example, glued) Trochar 120 to boss 156, and tube assembly 180 can fix (for example, glued) to well 154.Collet 122 can reset bullet Spring 152 is nearby fixed to collet retainer 150.As discussed herein, it is installed on right shell body 101 in collet retainer 150 Before, collet 122 can be pre-assembled to collet retainer 150.As shown, collet retainer 150 can have window 153, window 153 are sized to that collet retainer 150 is allowed to slide past well 154, so that when process of malleus wheel 140 drives collet retainer 150, Collet 122 can be mobile relative to insertion sleeve 124.

Figure 11 show by tube assembly 180 (for example, trochar 120 and insertion sleeve 124) be fixed to right shell body 101 it Before, the position that the locator tool that such as pneumatic tweezers 190 are equal adjusts the component of tube assembly 180 can be used.In shown implementation In example, pneumatic tweezers 190 are positioned between the well 154 for being arranged in right shell body 101 and reset spring 152 of grasping trochar 120 Part.In some embodiments, pneumatic tweezers 190 may be configured to along trochar 120 well 154 and process of malleus wheel 140 it Between extend part grasping trochar 120.

Figure 12 shows the top view of the pneumatic tweezers 190 of grasping trochar 120.In some embodiments, video is overlooked System can be used for assisting the placement of locator tool (for example, pneumatic tweezers 190).The display of video system is overlooked shown in In, it can be seen that pneumatic tweezers 190 grasp the trochar 120 of tube assembly 180.It can be seen that the fluting insertion tube 124 of tube assembly 180 Extend distad and on the boss of right shell body 101 156 far from reset spring 152.As shown, the nearside of trochar 120 End sections can extend above well 154.

Locator tool may include controlling locator tool along the freqency fine adjustment machine of the longitudinal axis of tube assembly 180 moved Structure (for example, micrometer).Locator tool can grasp and move the first component of tube assembly 180, to adjust the first component The position of another component relative to tube assembly 180.In some respects, collet 122 is positively retained at resting position (that is, not moving It is dynamic), and trochar 120 can be moved to relative to 122 locating support 200A of collet.In some embodiments, pneumatic tweezers 190 can be such that trochar 120 moves in collet 122, and implantation material 200 is located in collet 122.In some embodiments, Pneumatic tweezers 190 can make to be inserted into the position that sleeve 124 is mobile, with adjusting insertion sleeve relative to collet 122.In some embodiments In, pneumatic tweezers 190 can be such that insertion sleeve moves distally on collet 122.

Figure 13 A- Figure 13 C is shown using locator tool (for example, pneumatic tweezers 190) the mobile implantation in collet 122 Object 200.Figure 13 A shows trochar 120, collet 122 and distal part in each of insertion tube 124 of slotting.It can be seen that most Distal implant 200A is arranged in collet 122.Figure 13 B is shown have been distally advanced in collet 122 in trochar 120 Implantation material 200 is appropriately placed in collet 122 position of farthest side implantation material 200A later, as described herein. Figure 13 C is shown makes the distal end of farthest side implantation material 200A advance with remote with collet 122 using positioning tool The sectional view of the distal part of tube assembly 180 after side end 123 flushes.Video display system can be used for assisting to plant farthest side Enter object 200A to be positioned to flush with the distal end 123 of collet 122.

In some embodiments, after farthest side implantation material 200A is flushed with the distal end 123 of collet 122, positioning The micro-adjusting mechanism (for example, micrometer) of device tool (for example, pneumatic tweezers 190) can be relative to the mobile trochar 120 1 of collet 122 Offset distance.In some embodiments, offset distance causes implantation material 200 distad to protrude past the distal end of collet 122 123.In some embodiments, offset distance causes the distal end 123 of collet 122 to extend distally beyond implantation material 200 Distal end.In some embodiments, offset distance is between 0.00254mm and 0.0508mm, 0.00762mm and 0.0254mm Between, between 0.01016mm and 0.02032mm.In some embodiments, locator tool can be such that farthest side is implanted into Object 200A distad moves the offset distance of 0.01524mm relative to the distal end of collet 123.The initial position of bracket 200 The adjusting of distal end 123 relative to collet 122 improves the accuracy that collet 122 can be isolated by multiple brackets 200.When When setting initial position of the bracket 200 relative to the distal end 123 of collet 122, this method consider such as right shell body 101, The engineering tolerances of the device feature of process of malleus wheel 140 and collet retainer 150 etc..This generates can be by the small of arrangement close to each other Bracket 200 separate reliable and accurate conveying device 100.

Figure 14, which shows adhesive 20 (for example, Loctite), can be used for trochar 120 being fixed to well 154.In some realities Apply in example, adhesive 20 can be it is transparent or translucent, to allow to have applied in adhesive 20 with trochar 120 is fixed Visualization of the trochar 120 in well 154 after to well 154.As discussed, the side wall of well 154, which can have, extends through well The centring recesses of 154 diameter.The appropriate alignment for the trochar 120 that adhesive 20 allows visual confirmation to be fixed in well 154. In the shown embodiment, trochar 120 is confirmed by the gap (black arrow) between trochar 120 and the side wall of well 154 Appropriate alignment.In some embodiments, the appropriate side wall to alignment request trochar 120 and well 154 of trochar 120 will not be each other Directly contact.

Figure 15 shows the (figure of tube assembly 180 after trochar 120 has been secured to well 154 near reset spring 152 11) top view.In the nearside of reset spring 152, it can be seen that trochar 120 is glued to well 154 by adhesive 20.As schemed Show, insertion tube 124 is distally extending far from reset spring 152 and passes through the diameter of boss 156.Pneumatic tweezers 190 are positioned to grab Hold insertion tube 124.As explained about the trochar 120 in Figure 13, pneumatic tweezers 190 can be close to insertion tube 124 and making Insertion tube 124 is mobile relative to collet 122.

Figure 16 is to have made insertion tube 124 relative to the movement of collet 122 so that the distal side of insertion tube 124 in locator tool The sectional view of the distal end of tube assembly 180 after end is flushed with the distal end of collet 122.In some embodiments, In After the distal end of insertion tube 124 is flushed with the distal end of collet 122, locator tool (for example, pneumatic tweezers 190) Micro-adjusting mechanism (for example, micrometer) can be relative to mobile 124 1 offset distance of insertion tube of collet 122.In use, insertion tube 124 Can be located in front of conveying device 100 is activated near ocular tissue (for example, trabecular network), with collet 122 along trochar 120 driving implantation materials 200.In some respects, the offset distance of insertion tube 124 can determine that bracket 200 is transported in ocular tissue Distance or depth.In some embodiments, offset distance causes collet 122 distad to protrude past the distal side of insertion tube 124 End.In some embodiments, offset distance causes the distal end 124 of insertion tube 124 to extend distally beyond collet 122 Distal end.In some embodiments, offset distance between 0.254mm and 5.08mm, between 0.508mm and 2.54mm, Between 0.762mm and 1.016mm.In some embodiments, locator tool can make insertion tube 124 relative to collet The offset distance of 122 mobile 0.9144mm

It can be used for insertion tube 124 being fixed to the convex of right shell body 101 Figure 17 shows adhesive 20 (for example, Loctite) Platform 156.As discussed, the side wall of boss 156 can have the centring recesses for the diameter for extending through boss 156.Adhesive 20 Allow the appropriate alignment of the visual confirmation insertion tube 124 after insertion tube 124 is glued to boss 156.In the shown embodiment, The appropriate alignment of insertion tube 124 is confirmed by the gap (black arrow) between insertion tube 124 and the side wall of boss 156.One In a little embodiments, the appropriate of insertion tube 124 does not contact alignment request insertion tube 124 directly with the side wall of boss 156, or only exists It extends past and is directly contacted on the side of the groove of the diameter of boss 156.

Figure 18 is shown after tube assembly 180 has been secured to well 154 and boss 156 (as described above), is inserted into sleeve 108 It is mountable in tube assembly 180.In the shown embodiment, insertion sleeve 108 is placed in matrix 320, to help to cover insertion Cylinder 108 is directed on tube assembly 180.Being inserted into sleeve 108 has button connecting rod harness 188, and insertion sleeve 108 is connected to Sleeve retract button 114.As discussed, insertion sleeve 108 may be coupled to sleeve retract button 114, so that when pressing lower sleeve When retract button 114, insertion sleeve 108 is drawn proximally in tube assembly 180.Insertion sleeve 108 is moved proximally to The distal end that the distal end of tube assembly 180 can be manifested to insertion sleeve 108 in tube assembly 180, to position tube assembly 180 to convey implantation material 200.

Figure 19, which is shown, is inserted into insertion sleeve in the proximal end opening that tube assembly 180 has passed through insertion sleeve 108 The device 100 partly assembled after in 108.In the proximal end for being attached to insertion sleeve 108 of button connecting rod harness 188 Place is it can be seen that "T"-shaped reception slit 187.

Figure 20 shows the partly assembling after insertion sleeve button connecting rod 192 has been mounted in right shell body 101 Device 100.It attaches as shown, insertion sleeve retracts spring 109 to the proximal end of insertion sleeve button connecting rod 192. The distal end of insertion sleeve button connecting rod 192 can have protrusion 194, which is sized to and button connecting rod harness 188 "T"-shaped reception slit 187 (Figure 19) connection.

Figure 21 shows the dress partly assembled after sleeve retract button 114 has been mounted on right shell body 101 Set 100.Sleeve retract button 114 may be coupled to fin 196, and fin 196 extends to the slit of insertion sleeve button connecting rod 192 In 198.As shown, fin 196 can be configured to when pressing lower sleeve retract button 114 to the mobile insertion sleeve button of nearside Connecting rod 192.The mobile compressible insertion sleeve of nearside for being inserted into sleeve button connecting rod 192 retracts spring 109.When no longer press sleeve When retract button 114, the insertion sleeve of compression, which retracts spring 109 and can make to be inserted into sleeve button connecting rod 192 to be distally moved, to be returned to Its resting position.As discussed, insertion sleeve button connecting rod 192 can (for example, via button connecting rod harness 188) be attached to it is slotting Enter sleeve 108, so that the distal side movement of insertion sleeve button connecting rod 192 can make insertion sleeve 108 move distally to tube assembly On 180.In some embodiments, when sleeve retract button 114 is no longer pressed and is allowed to be returned to its resting position, Insertion sleeve 108 can move distally in tube assembly 180 so that tube assembly 180 to be pulled completely into insertion sleeve 108.

Figure 22, which shows insertion sleeve button connecting rod 192, may be coupled to button connecting rod harness 188.In the shown embodiment, The distal end for being inserted into sleeve button connecting rod 192 includes protrusion 194, and protrusion 194 is sized to and button connecting rod harness 188 "T"-shaped reception slit 187 connects, as discussed.When protrusion 194 is attached to "T"-shaped reception slit 187, insertion sleeve is pressed The mobile corresponding nearside for causing to be inserted into sleeve 108 of the nearside of button connecting rod 192 and distal side or distal side are mobile, as will be explained herein 's.

Figure 23 shows the fastening on left shell 103 to right shell body 101.As shown, working as left shell 103 and right shell body 101 when being pressed together, and buckle fixed link 400 can be used for applying equal pressure on the longitudinal length of left shell 103.Such as figure Shown, the top surface 402 of buckle fixed link 400 may include concave portion, which is sized to receive assembling device 100 People finger tip.Multiple liners 404 can extend from the bottom surface of bar 400.Each of liner 404 can be coupled by spring 406 To buckle fixed link 400.Compressed spring 406 is configured so to be applied to the pressure edge of the top surface 402 of buckle fixed link 400 The longitudinal length of left shell 103 be equably transmitted to liner 404.

Figure 24 is shown device 100 after left shell 103 has been fastened on right shell body 101 from Workpiece Holders 300 remove.As shown, fixture 160 is detached from from the state of holding meanss 100, and device 100 is in its distally and proximally end 105, it 106 is nearby grasped.Device 100 is along the direction being aligned with the longitudinal axis of centring pin 302 (Fig. 7) from Workpiece Holders 300 are lifted out directly up.

Although specific embodiment and it is exemplary it is disclosed in the context that manufacture ocular implants conveying device side Method, but it should be appreciated by those skilled in the art it is real to other substitutions that component extends beyond specifically disclosed embodiment Apply the purposes and its certain modifications and equivalent of example and/or embodiment.For example, although the method for assembling is retouched in some drawings State as wherein loading the conveying device there are four intraocular implant, but disclosed inventive concept can with there is dress The conveying device of be loaded in conveying device one, two, three or more than three intraocular implant is used in combination.

It is emphasized that can carry out many change and modification to the embodiments described herein, element is understood that For in other acceptable examples.All such modifications and variations be intended to be included in the scope of the present disclosure and by with Attached claim protection.In addition, any step described herein may be performed simultaneously or to be different from step as defined herein Rapid sequence executes.Additionally it should which it is clear that the feature and attribute of specific embodiment disclosed herein can be with different sides Formula is combined to form additional embodiment, and all these embodiments are both fallen in the scope of the present disclosure.

Unless expressly stated otherwise, or it is as used understand in other ways within a context, otherwise used here as Conditional statement, such as " can with ", " can with ", " possibility ", "available", " such as " etc. be typically aimed at and convey some embodiments to include Certain features, element and/or state, and other embodiments do not include these features, element and/or state.Therefore, this condition Language is generally not intended to imply that one or more embodiments need the feature, element and/or state in any way, or One or more embodiments must include for determining these features, member in the case where being with or without author's input or prompt Whether part and/or state include the logic that will be executed in any specific embodiment or in any specific embodiment.

In addition, following term may have been used herein.Unless the context clearly determines otherwise, otherwise singular " one, " one " and " being somebody's turn to do (described) " includes that plural number refers to object.Thus, for example, referring to including to one or more projects to project Refer to.Term " one " refers to one, two or more, and is commonly available to select some or all quantity.Term is " more It is a " refer to two or more projects.Term " about " or " approximation " be exponential quantity, size, size, configuration, parameter, shape and Other characteristics need not be accurately, but can according to need it is approximate and/or greater or lesser, with reflect acceptable tolerance, Conversion factor rounds up, measurement error etc. and other factors well known by persons skilled in the art.Term " substantially " means institute It states characteristic, parameter or value not needing accurately to realize, but the effect for not interfering the characteristic to be intended to provide may quantitatively occur The deviation or variation of fruit, including for example tolerance, measurement error, measuring accuracy limitation and it is well known by persons skilled in the art other Factor.

Numeric data may be indicated or be presented with range format.It is to be understood that this range format is just to side Just it and succinctly uses, and therefore should be interpreted flexibly to not only include the number clearly enumerated as the boundary of range Value, but also be interpreted as including comprising in the range all subranges or single number, such as each numerical value and sub- model It encloses and is expressly recited equally.As explanation, the numberical range of " about 1 to 5 " should be construed to include about 1 clearly enumerated To about 5 value, and should also be construed to further include each value and subrange in indicated range.Therefore, it is included in In the numberical range is individual value and such as " about 1 to about 3 ", " about 2 to about 4 " and " about 3 to about of such as 2,3 and 4 etc. 5 ", the subrange of " 1 to 3 ", " 2 to 4 ", " 3 to 5 " etc..This identical principle is suitable for only enumerating a numerical value (for example, " big In about 1 ") range, and no matter range width or described feature how to be all suitable for.For convenience's sake, Ke Neng Multiple projects are presented in common list.However, these lists should be interpreted that each component in list is identified separately For independent and unique component.Therefore, in the case where not opposite expression, the either member in this list shall not The equivalent being based only on the fact that they occur in common group and are interpreted any other component in same list. In addition, they should be interpreted broadly in the case where term "and" and "or" are used together with bulleted list, wherein institute Any one of project listed or more can be used alone or be used in combination with other projects being listed.Term " alternatively " refer to one selected in two or more alternative solutions, and be not intended to and selection is only restricted in those lists Alternative solution or be only restricted in listed alternative solution every time one, unless the context clearly indicates otherwise.