阅读说明：本技术 一种应用于制药配液系统中的无菌辅助灭菌装置 (A kind of sterile assisted sterilization device applied in pharmacy liquid mixing system ) 是由 王宪其 于 2019-07-31 设计创作，主要内容包括：本发明涉及一种应用于制药配液系统中的无菌辅助灭菌装置,包括精密过滤器、无菌转子变量泵、无菌气液扑集装置,精密过滤器经进气管路连接无菌转子变量泵的进气口,无菌转子变量泵的排气口经排水排气管路连接无菌气液扑集装置的进气口,无菌气液扑集装置的顶部开有蒸汽回流口,经灭菌管路连接无菌转子变量泵的蒸汽灭菌口。无菌转子变量泵的转子采用腰型结构,使得转子与转子之间以及转子与泵壳之间互不接触,实现高转速、高抽气率,本发明完成了抽排气、气液分离、高温蒸汽灭菌、液体回收等多功能,为一体式的无菌辅助灭菌装置。(The present invention relates to a kind of sterile assisted sterilization devices applied in pharmacy liquid mixing system, acquisition means are flutterred including accurate filter, sterile rotor variable pump, sterile gas-liquid, accurate filter connects the air inlet of sterile rotor variable pump through air inlet pipeline, the exhaust outlet of sterile rotor variable pump flutters the air inlet of acquisition means through the sterile gas-liquid of drainage exhaust piping connection, sterile gas-liquid, which is flutterred at the top of acquisition means, is provided with opposing steam flow mouth, the steam sterilizing mouth of the sterilized sterile rotor variable pump of piping connection.The rotor of sterile rotor variable pump uses waist type structure, so that being not in contact with each other between rotor and rotor and between rotor and pump case, realize high revolving speed, high suction performance, the present invention completes that exhaust, gas-liquid separation, high-temp steam sterilizing, liquids recovery etc. are multi-functional, is the sterile assisted sterilization device of integral type.)

1. a kind of sterile assisted sterilization device applied in pharmacy liquid mixing system, it is characterised in that: including accurate filter (1), sterile rotor variable pump (2), sterile gas-liquid are flutterred acquisition means (3), and accurate filter (1) connects sterile through air inlet pipeline (4) The exhaust outlet of the air inlet of rotor variable pump (2), sterile rotor variable pump (2) connects sterile gas-liquid through drainage exhaust pipeline (12) The air inlet of acquisition means (3) is flutterred, sterile gas-liquid, which is flutterred at the top of acquisition means (3), is provided with opposing steam flow mouth, sterilized pipeline (6) connection The steam sterilizing mouth of sterile rotor variable pump (2).

2. the sterile assisted sterilization device according to claim 1 applied in pharmacy liquid mixing system, it is characterised in that: institute A pair of of rotor (5) that sterile rotor variable pump (2) includes pump case He is arranged in pump case is stated, the rotor (5) is waist type structure And the molded line of rotor (5) is involute.

3. the sterile assisted sterilization device according to claim 1 applied in pharmacy liquid mixing system, it is characterised in that: institute Sterile gas-liquid is stated to flutter acquisition means (3) as drum-type container structure and be from top to bottom divided into cushion chamber, splitter cavity and collecting chamber, cushion chamber It is interior to be equipped with cleaning spray ball (8), it cleans spray ball (8) and passes through external connection water washing device at the top of cushion chamber, splitter cavity is using burning Eliminant metal filtration plate (11) is separated with collecting chamber, and collecting chamber bottom connects recyclable device (14).

4. the sterile assisted sterilization device according to claim 3 applied in pharmacy liquid mixing system, it is characterised in that: institute State sterile gas-liquid and flutter the inner walls of acquisition means (3) and handled using mirror finish, outer wall successively wrap up from inside to outside temperature-control coating (10) and Insulating layer (9), temperature-control coating (10) upper and lower ends are equipped with connecting pipe, are passed through cooling water or high-temperature steam for recycling.

5. the sterile assisted sterilization device according to claim 1 applied in pharmacy liquid mixing system, it is characterised in that: also Including temperature control device, the temperature control device includes that operation temperature controller and the temperature being connected with the operation temperature controller pass Sensor and alarm, the temperature sensor are mounted in accurate filter (1) cavity.

6. the sterile assisted sterilization device according to claim 5 applied in pharmacy liquid mixing system, it is characterised in that: institute Drainage exhaust pipeline (12) are stated equipped with motor-operated control valve (13), are electrically connected with operation temperature controller, for controlling electronic control The open and close of valve (13) processed.

7. the sterile assisted sterilization device according to claim 1 applied in pharmacy liquid mixing system, it is characterised in that: institute It states opposing steam flow mouth and connects the air inlet that sterile gas-liquid flutters acquisition means (3) through opposing steam flow pipeline (7).

Technical field

The present invention relates to technical field of fine more particularly to a kind of sterile auxiliary applied in pharmacy liquid mixing system Bactericidal unit.

Background technique

Filter element of precision filter needs to sterilize online during pharmaceutical manufacturing, and the temperature to sterilize online is usually 121 DEG C, The saturated vapour pressure being equivalent under 0.12MPa.Filter core is that wet, wet filter core can generate moisture film when online sterilizing, so And the pure steam under 0.3MPa can not all penetrate filter core.Therefore online sterilizing is not thorough.To achieve the purpose that thoroughly to sterilize, utilize The working principle of vacuum pump aspirates filter core cavity, so that the intracorporal gas-liquid of chamber be made to extract out together, conventional vacuum pump can not be held By, and gas-liquid can be expelled directly out, and easily cause secondary pollution.It is difficult to meet pharmaceutical manufacturing environmental impact assessment requirement.

Summary of the invention

The purpose of the present invention is to provide a kind of sterile assisted sterilization devices applied in pharmacy liquid mixing system, solve essence Close filter element sterilizes halfway problem during pharmaceutical manufacturing.

To achieve the above object, technical scheme is as follows:

A kind of sterile assisted sterilization device applied in pharmacy liquid mixing system, including accurate filter, sterile rotor become Amount pump, sterile gas-liquid flutter acquisition means, and accurate filter connects the air inlet of sterile rotor variable pump, sterile rotor through air inlet pipeline The exhaust outlet of variable pump flutters the air inlet of acquisition means through the sterile gas-liquid of drainage exhaust piping connection, and sterile gas-liquid flutters the top of acquisition means Portion is provided with opposing steam flow mouth, the steam sterilizing mouth of the sterilized sterile rotor variable pump of piping connection.

Further, the sterile rotor variable pump includes pump case and a pair of of rotor for being arranged in pump case, the rotor Molded line for waist type structure and rotor is involute.

Further, the sterile gas-liquid flutters packaging and is set to drum-type container structure and is from top to bottom divided into cushion chamber, shunts Chamber and collecting chamber, cushion chamber is interior to be equipped with cleaning spray ball, and cleaning sprays ball and passes through external connection water washing device at the top of cushion chamber, point Stream chamber is separated using sintered type metal filtration plate with collecting chamber, and collecting chamber bottom connects recyclable device.

Further, the inner wall of the drum-type container is handled using mirror finish, and outer wall successively wraps up temperature adjustment from inside to outside Layer and insulating layer, the temperature-control coating upper and lower ends are equipped with connecting pipe, are passed through cooling water or high-temperature steam for recycling.

Further, further include temperature control device, the temperature control device include operation temperature controller and with the operation temperature Controller connected temperature sensor and alarm are spent, the temperature sensor is mounted in accurate filter cavity.

Further, the drainage exhaust pipeline is equipped with motor-operated control valve, is electrically connected, is used for operation temperature controller Control the open and close of motor-operated control valve.

Further, the opposing steam flow mouth flutters the air inlet of acquisition means through the sterile gas-liquid of opposing steam flow piping connection.

The sterile assisted sterilization device being applied in pharmacy liquid mixing system of the invention has the advantages that

1, the rotor of sterile rotor variable pump uses waist type structure so that between rotor and rotor and rotor and pump case it Between be not in contact with each other, realize high revolving speed, high suction performance；Meanwhile sterile rotor variable pump can be used alone, and complete to corrosive media Feeding work；

2, the inner surface that sterile gas-liquid flutters acquisition means is handled using mirror finish, had not only been met cleaning requirement but also can have been gone out with high temperature Bacterium, disengagement chamber are separated using sintered type metal filtration plate and collecting chamber.Using the structure of sandwich-type, when high-temperature steam is inhaled into point Chamber is flowed, temperature-control coating will be condensed into the condensed water of recoverable by cooling water, high-temperature steam.Acquisition means are being flutterred by setting The refluxing opening at top is collected and secondary use the high-temperature steam for having not enough time to condensation, increases the fractional energy savings of equipment；

3, the present invention complete exhaust, gas-liquid separation, liquids recovery, sterile steam sterilizing etc. it is multi-functional, be integral type Sterile assisted sterilization device.

Detailed description of the invention

Fig. 1 is the structural representation for the sterile assisted sterilization device being applied in pharmacy liquid mixing system in one embodiment of the invention Figure；

Description of symbols: 1, accurate filter, 2, sterile rotor variable pump, 3, sterile gas-liquid flutter acquisition means, 4, air inlet Pipeline, 5, rotor, 6, sterilizing pipeline, 7, opposing steam flow pipeline, 8, cleaning spray ball, 9, insulating layer, 10, temperature-control coating, 11, metal Filter plate, 12, drainage exhaust pipeline, 13, motor-operated control valve, 14, recyclable device.

Specific embodiment

Technical solution of the present invention is described in further detail with reference to the accompanying drawings and examples.

Such as Fig. 1, a kind of sterile assisted sterilization device applied in pharmacy liquid mixing system of the invention, including secondary filter Device 1, sterile rotor variable pump 2 and sterile gas-liquid flutter acquisition means 3, wherein the upper end side of sterile rotor variable pump 2 is equipped with air inlet Mouthful, the upper end other side be equipped with steam sterilizing mouth, lower end side be equipped with exhaust outlet, sterile gas-liquid flutter acquisition means 3 side be equipped with into Port, top are equipped with opposing steam flow mouth.Accurate filter 1 connects the air inlet of sterile rotor variable pump 2, nothing through air inlet pipeline 4 The exhaust outlet of bacterium rotor variable pump 2 connects the air inlet that sterile gas-liquid flutters acquisition means 3 through drainage exhaust pipeline 12, and sterile gas-liquid is flutterred The sterilized pipeline 6 of opposing steam flow mouth at 3 top of acquisition means connects the steam sterilizing mouth of sterile rotor variable pump 2.

Wherein, sterile rotor variable pump 2 is mainly made of pump case and a pair of of the waist type construction rotor 5 being arranged in pump case, The upper end of pump case is equipped with air inlet and steam sterilizing mouth, and lower end is equipped with exhaust outlet, steam sterilizing mouth and exhaust outlet dislocation point Cloth, can effectively avoid short circuit phenomenon when steam sterilizing, waist type structure makes between rotor 5 and rotor 5, rotor 5 and pump case it Between be not in contact with each other, and gap control is in 0.5-0.8mm, meanwhile, the molded line of rotor 5 is involute, and volume is big, and utilization rate is high, is turned Son 5 is connected to the motor through bearing, is electrified, sterile rotor variable pump 2 can work.

It is drum-type container structure that sterile gas-liquid, which flutters acquisition means 3, is made of the stainless steel of S316L material, and from top to bottom It is divided into cushion chamber, splitter cavity and collecting chamber.Wherein, cleaning spray ball 8 is equipped in cushion chamber, cleaning spray ball 8 passes through cushion chamber Top external connection water washing device is used for on-line cleaning container intracavity；Splitter cavity uses sintered type metal filtration plate 11, plays Filter centrifugation；Collecting chamber bottom connects recyclable device 14.Opposing steam flow mouth is provided at the top of drum-type container, through opposing steam flow pipe Road 7 connects the air inlet of drum-type container, and opposing steam flow pipeline 7 is equipped with valve, for controlling the flow direction for not flutterred the steam of collection.

The inner wall of drum-type container is handled using mirror finish, and outer wall successively wraps up temperature-control coating 10 and insulating layer 9 from inside to outside, Temperature-control coating 10 can be passed through cooling water and high-temperature steam, and insulating layer 9 plays the role of being isolated from the outside, and play protection staff. When needing high-temperature steam becoming condensed water, to prevent water short-circuit, intake from the connecting pipe of 10 lower end of temperature-control coating, from temperature adjustment The connecting pipe water outlet of 10 upper end of layer, bottom in and top out, circulation are passed through cooling water, thus by high-temperature steam be condensed into it is clean, can return The condensed water of receipts is recycled.When carrying out the sterilizing of sterile rotor variable pump 2, if sterile gas-liquid flutters the steaming of the high temperature in acquisition means 3 Vapour is not achieved 121 °, is passed through high-temperature steam, company of the high-temperature steam from 10 lower end of temperature-control coating from the connecting pipe of 10 upper end of temperature-control coating Adapter tube is said, and circulation is passed through high-temperature steam, so that sterile gas-liquid flutters the heating of the high-temperature steam in acquisition means 3, obtains that nothing can be made The high-temperature steam that bacterium rotor variable pump 2 sterilizes.

In one embodiment, further include temperature control device, temperature control device include operation temperature controller and with operation temperature control Device processed connected temperature sensor and alarm.Wherein, the model PT-7 series of operation temperature controller, supports PID+ Fuzzy+ programmable control model, the model PT100 of temperature sensor, temperature sensor are mounted on 1 cavity of accurate filter It is interior, for measuring the temperature in accurate filter 1, when reaching the setting value of operation temperature controller, alarm starting, together When, operation temperature controller control motor-operated control valve 13 open so that the steam and liquid extracted out by sterile rotor variable pump 2 into Enter sterile gas-liquid to flutter in acquisition means 3, filling circulation cooling water in temperature-control coating 10, thus by high-temperature steam be condensed into it is clean, can return The condensed water of receipts.

In one embodiment, the sterilized pipeline 6 of opposing steam flow mouth that sterile gas-liquid flutters acquisition means 3 connects sterile rotor variable The both ends of the steam sterilizing mouth of pump 2, sterilizing pipeline 6 are equipped with valve, when sterile rotor variable pump 2 needs to sterilize, sterile gas Liquid flutters the pure high-temperature steam in acquisition means 3 and enters sterile rotor variable pump 2 by sterilizing pipeline 6, in sterile rotor variable pump 2 Portion's structure carries out sterilizing works, plays the effect for recycling high-temperature steam.

In pharmacy procedure, sterile rotor variable pump 2 starts, and is made by pushing that is synchronous to waist type rotor 5, reversely rotating Vacuumizing and exhausting function is realized with mobile gas, and contains steam in pumped gas, and sterile rotor variable pump 2 is through drainage tracheae Steam and condensed water are sent into sterile gas-liquid and flutter acquisition means 3 by road 12, and through cushion chamber, part vapor is tempered the cooling water in layer Condensation becomes condensed water, recycles after the filtering of metal filtration plate 11, is not flutterred the vapor collected through opposing steam flow pipeline 7 again Acquisition means 3 are flutterred into sterile gas-liquid, are recycled again, circulation repeatedly flutters collection recycling.

Above-described specific embodiment has carried out further the purpose of the present invention, technical scheme and beneficial effects It is described in detail, it should be understood that the foregoing is merely a specific embodiment of the invention, the guarantor that is not intended to limit the present invention Range is protected, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should all be contained in this hair Within bright protection scope.