阅读说明：本技术 可植入腔室外压力传感器 (Implantable chamber external pressure sensor ) 是由 达米恩·C·罗杰 戴聿昌 马克·S·胡马云 奥布里·M·夏皮罗 阿比纳弗·阿格瓦尔 A·埃 于 2018-04-09 设计创作，主要内容包括：描述了一种微型低功率电子压力传感器,其具有用于保护其微机电系统(MEMS)压敏膜的第一充油腔室和填充有盐水或体液的第二腔室,该盐水或体液通过导管连接到身体中需要压力感测的器官,例如眼球。该导管将压力从器官内的敏感区域传递到电子压力传感器。该压力传感器可以与外部读取器无线通信,并将数据传递给服务器或其他计算机。沿着导管行进的是用于引流和卸压的另一个导管。这些导管或套管可以共用一个通向器官的开口,以将所需的孔数减至最小。该导管可以被模制成单个椭圆形截面、同轴地组合或者共用进入器官壁的部分的内腔,以便促进愈合。(Describe a kind of miniature low power electronics pressure sensor; it has for protecting the first oil-filled chamber of its MEMS (MEMS) pressure-sensitive film and the second chamber filled with salt water or body fluid; the salt water or body fluid are connected to the organ that pressure-sensing is needed in body, such as eyeball by conduit.Pressure is transmitted to electronic pressure transmitter from intraorganic sensitizing range by the conduit.The pressure sensor can be wirelessly communicated with external reader, and pass data to server or other computers.What it is along conduit traveling is for draining and another conduit of release.These conduits or casing can share one and lead to organotropic opening, and required hole count is minimized.The conduit can be molded into single elliptic cross-section, coaxially combine or share the inner cavity into the part of organ walls, to promote to heal.)

1. a kind of implantable pressure sensor apparatus, comprising:

Electronic pressure transmitter, the electronic pressure transmitter have pressure-sensitive film；

Oil-in chamber, the oil-in chamber encapsulate the pressure-sensitive film, and the oil-in chamber is oily filled with biocompatibility, and at least one Side has flexible membrane；

Salt water chamber, the salt water chamber are located at the opposite side with the oil-in chamber of the flexible membrane；

Casing is sensed, the sensing casing, which has, extends to the inner cavity in the salt water chamber；

Drainage casing tube, the drainage casing tube have and the part for sensing box abutment and extending in parallel；With

Current limiter, the current limiter is in the drainage casing tube.

2. the apparatus according to claim 1, further includes:

The filling wedge in recess portion between the sensing casing and the drainage casing tube of adjoining, the filling wedge, sensing casing and institute It states drainage casing tube and forms oval cross section.

3. the apparatus of claim 2, wherein the filling wedge extends to the drainage casing tube and sensing set of the adjoining The end of pipe.

4. device according to claim 3, wherein the end is inclined.

5. the apparatus of claim 2, wherein the filling wedge includes cure silicone rubber.

6. the apparatus according to claim 1, wherein the current limiter close to the free end of the drainage casing tube, it is described from It is opposite with having the end of part that is adjacent and extending in parallel by holding.

7. the apparatus according to claim 1, wherein the sensing casing and the drainage casing tube are in the adjoining and parallel At the part of extension coaxially to each other.

8. the apparatus according to claim 1, wherein the sensing casing and the drainage casing tube are intersected with public interior The common cannula of chamber.

9. the apparatus according to claim 1, further includes:

Microballon, for the microballon in the current limiter, the assembling of the microballon is configured to limit fluid flowing.

10. device according to claim 9, further includes:

Injection port, on the current limiter, the injection port is configured as allowing to connect by spicule the injection port The nearly microballon.

11. the apparatus according to claim 1, wherein the current limiter includes mechanical valve.

12. the apparatus according to claim 1, further includes:

Flexible printed circuit board (PCB)；

Coil, the coil are connect with the PCB；

Wireless transmitter, the wireless transmitter are connect with the coil；With

Integrated circuit (IC), the integrated circuit are configured as through the wireless transmitter and coil transmission from the electronics The pressure reading of pressure sensor.

13. the apparatus according to claim 1, wherein the compatible oil of the silicon of the biocompatibility includes silicone oil.

14. the apparatus according to claim 1, wherein the flexible membrane includes Parylene.

15. the apparatus according to claim 1, further includes:

Glass plate, the glass plate are suspended in above the flexible membrane.

16. the apparatus according to claim 1, wherein the salt water chamber is made of semi-rigid polymer.

17. a kind of method for manufacturing implantable pressure sensor apparatus, which comprises

The lid of electronic pressure transmitter is removed to expose the pressure-sensitive silicon fiml in groove；

The groove around the pressure-sensitive silicon fiml is filled with oil；

By parylene deposition to form flexible membrane on the oil, the flexible membrane forms the side of oil-filled chamber；With

Installation has the lid of conduit on the flexible membrane, to establish salt water chamber and sensing casing.

18. according to the method for claim 17, wherein the adjacent sensing casing of drainage casing tube is simultaneously parallel to the sensing Casing extends.

19. according to the method for claim 18, wherein the drainage casing tube includes current limiter.

20. according to the method for claim 18, further includes:

The implantable pressure sensor apparatus is attached on eyeball by surgical operation；With

The end of the sensing casing and the drainage casing tube is inserted by the notch in the orbiculus ciliaris of eyeball.

1. technical field

The embodiment of the present invention relates generally to the biography of the pressure for measuring the pressure in the chamber interior in patient body Sensor, the pressure sensor include the implantable electronic sensor for measuring intraocular intraocular pressure (IOP), the implantable biography Sensor facilitates the maintenance of pressure relief devices.

2. description of related art

Glaucoma is to lead to the second largest reason of blindness, influences global 60,000,000 people.One main hazard of glaucoma because Element is that intraocular pressure (IOP) is increased, this can damage optic nerve and cause to blind.Currently used for monitor IOP nursing standard be Goldmann applanation tonometry, wherein patient periodically arrives the single measurements that doctor's office registration is gone to a doctor every time.Many institutes Known, IOP whole day fluctuation, measurement infrequently may miss raised IOP peak value, lead to the assessment of inaccuracy.

For Accurate Diagnosis, need continuously to can plant IOP monitor to monitor treatment and avoid preventible permanent Visual loss.

Since the sensor as caused by chemical-biological factor (such as hydrolysis corrosion and biological attachment (biofouling)) floats It moves, implantable IOP sensor is difficult to securely maintain in the case where not recalibrating < and the clinical accuracy target of 2mmHg is super Spend one month.The so short service life prevents the use of IOP monitoring implantation material with having reason.

The 2016/0287101A1 United States patent publication for authorizing Tai et al. discloses a kind of implantable sensor envelope Dress, the encapsulation are separated body fluid by surrounding sensing film with liquid from sensing film.This sensor encapsulation design is extending The average time between failures (MTBF) and service life aspect of implantable pressure sensor show fabulous prospect.

Measurement pressure is the half of problem.Release is the other half.It can be eased off the pressure with implantable shunt pipe.However, being used for Discharge eye fluids and the conduit for mitigating eye pressure are also often subject to biological attachment.Due to biological attachment, it is implanted into sometimes more Root conduit, in this way, if a blocking, it is likely that be smooth another.

Need the improved device and method of the IOP for measuring IOP and mitigation patient's eye.

Brief overview

Generally speaking, content proposed in this paper is related to a kind of miniature implantable pressure sensor, which has Oil-filled bag (oil-filled bag) or the other flexible membranes for protecting its film sensors.Pressure sensor is mounted on eyeball sclera Outside, conduit (casing) pass through orbiculus ciliaris from pressure sensor and enter eyeball.Meanwhile drainage catheter (casing) is along pressure Power conduit extends into eyeball, shares the operative incision into orbiculus ciliaris.Drainage catheter has an eye outside eyes The current limiter that section doctor is easy to use.

Other than eyes, the also available service of other organs.For example, bladder, brain, aorta or other organs can There is the implantable pressure sensor being outside it and enter the sensor and drainage catheter in them.

In the region that conduit passes through operative incision, catheter pressure and drainage catheter can be coaxial, share one and lead Pipe, or it is conformal to form smooth oval cross-section with wedge.It can be with the spicule of doctor to the injection on current limiter Microballon is filled up in port.

Some embodiments of the present invention are related to implantable pressure sensor apparatus.The device includes: electronic pressure transmitter, The electronic pressure transmitter has pressure-sensitive film；Oil-in chamber, the oil-in chamber encapsulate pressure-sensitive film, which is filled with biocompatibility Oil, and there is flexible membrane at least side；Salt water chamber, the salt water chamber are located at the opposite side with oil-in chamber of flexible membrane； Casing is sensed, which, which has, extends to the inner cavity in salt water chamber；Drainage casing tube, which has covers with sensing Part pipe adjoining and extended in parallel；And current limiter, the current limiter is in drainage casing tube.

The apparatus may include: the filling wedge in recess portion between sensing casing and adjacent drainage casing tube, filling wedge, sensing Casing and drainage casing tube form oval cross section.Filling wedge extends to the end of adjacent drainage casing tube and sensing casing Portion.The end can be inclined.Filling wedge can be cure silicone rubber.

Current limiter can be close to the free end of drainage casing tube, the free end and the end with part that is adjacent and extending in parallel Portion is opposite.Sensing casing and drainage casing tube can be at parts that is adjacent and extending in parallel coaxially to each other.Sense casing and drainage Casing can intersect (for example, being connected with Y-shaped or with "T"-shaped connection) into the common cannula with public inner cavity.

There can be microballon in current limiter, the assembling of microballon is configured as limitation fluid flowing.There can be injection on current limiter Port, the injection port are configured as allowing to contact microballon by spicule.Alternatively, or in combination with, current limiter may include machine Tool valve.

The device can also include flexible printed circuit board (PCB), connect with PCB coil, connect with coil it is wireless It transmitter and is configured as transmitting the integrated of the pressure reading from electronic pressure transmitter by wireless transmitter and coil Circuit (IC).

Biocompatibility oil can be the compatible silicone oil of silicon (Si).Silicone oil is typically superior to silica gel, because absorbed on silica gel water steams Gas, and water can cause to corrode.Flexible membrane can be made of Parylene.Glass plate can be suspended in above flexible membrane.Salt water cavity Room can be made of semi-rigid polymer.

Some embodiments are related to a kind of method for manufacturing implantable pressure sensor apparatus.This method comprises: removing The lid of electronic pressure transmitter is to expose the pressure-sensitive silicon fiml in groove；It is filled with oil described recessed around the pressure-sensitive silicon fiml Slot；By parylene deposition to form flexible membrane in oil meter face, which forms the side of oil-filled chamber；And soft Property film on installation have conduit lid, with establish salt water chamber and sensing casing.

Drainage casing tube box abutment and can be extended in parallel with sensing.Drainage casing tube may include current limiter.This method is also It may include: that implantable pressure sensor apparatus is attached on eyeball by surgical operation；And the ciliary body for passing through eyeball The end of notch insertion sensing casing and drainage casing tube in flat part.