阅读说明：本技术 温感组合物以及含有该温感组合物的气溶胶制剂 (Warming composition and aerosol preparation containing the warming composition ) 是由 上条北斗 中岛康友 胁原徹 米泽泰夫 于 2017-05-22 设计创作，主要内容包括：本发明的问题在于,提供一种长期保存后的分散稳定性良好、温感刺激性强、沸石特有的使用感的降低得以改善的温感组合物以及含有该温感组合物的气溶胶制剂。因含有平均粒径为500nm以下的沸石纳米粒子的温感组合物的沸石与水分的水合反应而产生的热使组合物的温度迅速上升,由此解决了问题。(Problem of the invention is that the warming composition that a kind of dispersion stabilization after providing long-term preservation is good, warming irritation is strong, the distinctive use feeling of zeolite reduction is improved and the aerosol preparation containing the warming composition.The heat generated due to the hydration reaction of the zeolite containing the warming composition that average grain diameter is 500nm zeolite nanoparticle below and moisture rises rapidly the temperature of composition, thus solves the problems, such as.)

1. a kind of warming composition, wherein

It is 500nm zeolite nanoparticle below containing average grain diameter.

2. warming composition according to claim 1, wherein

Also contain polyalcohol.

3. warming composition according to claim 1 or 2, wherein

Also contain tackifier or dispersing agent.

4. warming composition described in any one of claim 1 to 3, wherein

The warming composition is gel dosage form or creams dosage form.

5. a kind of aerosol preparation, wherein

The second container of the first container and storage second chamber of storing first chamber is accommodated in the row for having output mechanism Out in container, and it is filled with stock solution being formed in the space in discharge container between the first container and second container, Wherein, the first chamber at least contains composition according to any one of claims 1 to 4, and the second chamber is extremely Contain water less.

6. a kind of aerosol preparation, wherein

The first container of storage first chamber is accommodated in the discharge container for having output mechanism, and the shape in discharge container Stock solution is filled at the space between the first container and the next door of discharge container, wherein the first chamber at least contains Composition described in having the right to require any one of 1~4.

7. aerosol preparation according to claim 6, wherein

The filler of the first container and the filler of the second container is discharged simultaneously in the output mechanism.

8. a kind of aerosol preparation, wherein

The second container of the first container and filling second chamber of filling first chamber is accommodated in the row for having output mechanism Out in container, and it is filled with stock solution in the space being formed between discharge container and the first container and second container, In, it is 500nm zeolite nanoparticle below that the first chamber, which at least contains average grain diameter, and the second chamber is at least Containing water,

It is contacted using the discharged first chamber of the stock solution and the second chamber, thus heat production.

Technical field

The present invention relates to a kind of warming composition containing pyrogen and the aerosol systems containing the warming composition Agent.

Background technique

There is heat generation if making the composition of the skin suitable for human body, can expect the various of referred to as thermogenetic effect Effect, such as following effects: the pleasant sensation because of caused by warming when coating；Skin swashs because of caused by sanguimotor promotion (fatigue recovery, activeization of metabolism, beautiful raising etc.) living；The epidermis dirt because of caused by the expansion of pore, heat Removal improves；Deng.

As the preparation for the heat generation for bringing such effect, a kind of composition has been developed, it will be containing zeolite, polynary The composition of alcohol is suitable for skin, generates heat and the moisture with skin reacts (for example, with reference to 1~patent of patent document Document 3).These preparations are filled primarily with to be saved in pipe (tube) etc., as a result, existing at the Kaifeng of lid etc. The case where zeolite, polyalcohol adsorb the moisture in air, there are problems for storage stability.Additionally, there are in the amount of moisture of skin Limited, warming irritation (warming impact) is weak.

For such problems, it is known that enclose into airtightness high aerosol container heat generation composition, thus mention High storage stability.For example, in patent document 4, using with stock solution filling space and two stostes filling space Aerosol container airtightness is improved by using such aerosol container, the further sky by making to fill pyrogen Between with filling water space separate, mixed using injection, can be improved warming irritation.

Summary of the invention

Problem to be solved by the invention

The inventors of the present invention contemplate following situation: containing the composition of zeolite and only using polyalcohol as heating composition progress The composition used compares, and generates the reduction (harsh feeling) of the distinctive use feeling of zeolite.In addition, also there is following such dispersion The problem of stability, that is, after saving for a long time in the container of filled compositions, the zeolite as powder can settle that (first asks Topic).

In addition, the inventors of the present invention to using warming composition as aerosol preparation carry out using situation studied, As a result there are the following problems: although aerosol preparation has the output mechanism for spraying composition using stock solution, Using in the aerosol preparation of zeolite, the zeolite as powder can make output mechanism block (Second Problem).

The present invention solves these problems.

The solution to the problem

In order to solve these problems, the inventors of the present invention have made intensive studies, it was found that: by using the boiling of nano-scale Stone replaces the zeolite of the micron-scale used in the past, is able to solve the above problem.

First purport of the invention is a kind of warming composition, and at least containing average grain diameter is 500nm zeolite below Nanoparticle.

Preferably, the warming composition also contains polyalcohol.

In addition, the second purport of the invention is a kind of aerosol preparation, the first container and storage of first chamber are stored The second container of second chamber is accommodated in the discharge container for having output mechanism, and is being formed in discharge container and the Space between one container and second container is filled with stock solution, wherein the first chamber at least has containing average Partial size is the composition of 500nm zeolite nanoparticle below, and the second chamber at least has water.

Preferably, the first chamber also contains polyalcohol, it is preferred that stores the first container of first chamber It is accommodated in the discharge container for having output mechanism, and is formed in the first container in discharge container and the next door of container is discharged Between space be filled with stock solution, the filler of the first container and the filler of the second container is discharged simultaneously.

In addition, third purport of the invention is a kind of aerosol preparation, the first container for storing first chamber is accommodated in Have in the discharge container of output mechanism, and is formed in the first container in discharge container and is discharged between the next door of container Space is filled with stock solution, wherein it is 500nm zeolite nanometer below that the first chamber, which at least has containing average grain diameter, The composition of particle.

Preferably, the first chamber also contains polyalcohol.

In addition, the 4th purport of the invention is a kind of aerosol preparation, the first container and filling of first chamber are filled The second container of second chamber is accommodated in the discharge container for having output mechanism, and is being formed in discharge container and first Space between container and second container is filled with stock solution, wherein the first chamber is at least containing average grain diameter 500nm zeolite nanoparticle below, the second chamber at least contain water, utilize the stock solution discharged described One composition and second chamber contact, thus heat production.

Preferably, the first chamber also contains polyalcohol.

Invention effect

In accordance with the invention it is possible to which a kind of dispersion stabilization after providing long-term preservation is good, warming irritation is strong, zeolite is special The warming composition that the reduction of some use feelings is improved.

In addition, aerosol preparation of the invention can prevent in the blocking of output mechanism and the air during preservation The aggravation of moisture and the zeolite in warming composition reacted.In turn, in aerosol container, by warming composition and contain The composition of water encloses different spaces respectively, is mixed these compositions using injection, thereby, it is possible to improve warming stimulation Property, and it is unrelated with the amount of moisture for being present in skin.

Detailed description of the invention

Fig. 1 is the schematic front view of the aerosol preparation of one embodiment of the present invention.

Fig. 2 is the schematic front view of the aerosol preparation of one embodiment of the present invention.

Fig. 3 is the schematic front view of the aerosol preparation of one embodiment of the present invention.

Fig. 4 is to indicate the photo of the dispersion stabilization of warming composition of one embodiment of the present invention (instead of attached drawing Photo).

Fig. 5 is the skeleton diagram for measuring the device of warming composition to heat up at any time.

Fig. 6 is the curve graph to heat up at any time for indicating the warming composition of one embodiment of the present invention.

Specific embodiment

The present invention will be described for embodiment described below, but the present invention is not limited only to specific embodiment.

First embodiment of the invention is a kind of warming composition, and at least containing average grain diameter is that 500nm is below Zeolite nanoparticle.

" warming composition " used in the present invention refers to, the composition to be generated heat and reacting with water is being discharged To human body palm when and the moisture of palm react and generate heat, or it is anti-by occurring with the water (aqueous solution) separately prepared It answers and generates heat.

Zeolite nanoparticle used in the present invention refers to that average grain diameter is 500nm zeolite nanoparticle below, passes through Hydration heat is blended to produce with water.The lower limit value of average grain diameter is not particularly limited, preferably 5nm or more, more preferably 10nm More than, further preferably 20nm or more is even more preferably 25nm or more.In addition, upper limit value be preferably 400nm hereinafter, More preferably 300nm hereinafter, further preferably 200nm hereinafter, even more preferably be 150nm or less.

Average grain diameter illustrates in greater detail below, is the value of the number average bead diameter determined by scanning electron microscope.

As zeolite used in warming composition of the invention, it can enumerate and be registered in International SiO among the skeleton of Zeolite Association (International Zeolite Association)₂/Al₂O₃Than for 40 or less, preferably 20 or less, More preferably 6 zeolites below.

Wherein, as in the present invention it is preferable to use zeolite, type A zeolite nanoparticle can be enumerated, for example, (1-x) Na₂O·xK₂O·Al₂O₃·2SiO₂The synthetic zeolite 3A type of (x≤0.95), Na₂O·Al₂O₃·2SiO₂Synthetic zeolite 4A Type, (1-x) Na₂O·0.5xCaO·Al₂O₃·2SiO₂The synthetic zeolite 5A type of (x≤0.95) etc..

In 100 mass % of warming composition, the content of zeolite nanoparticle is usually 1~70 mass %, and lower limit is preferred For 3 mass % or more, more preferably 5 mass % or more, in addition, the upper limit is preferably 60 mass % hereinafter, more preferably 50 matter Measure % or less.

The content of zeolite within the above range in the case where, can obtain warming composition sufficient warming effect, Temperature, which will not occur, becomes excessively high to the degree for leading to skin scald.In addition, warming composition is discharged from aerosol container When have viscosity appropriate.

Preferably, warming composition contains polyalcohol.Polyalcohol reacts with water and is generated heat, in addition, can become The principal component of the liquid medium of zeolite.

It as the concrete example of polyalcohol used in warming composition, such as can enumerate: propylene glycol (PG), 1,3-BDO (BG), the polyalcohol being in a liquid state under the room temperature such as polyethylene glycol (PEG), glycerol, polyglycereol (20 DEG C of temperature).These polyalcohols can be with One kind is used alone, two or more combinations can also be carried out using.

Wherein, from the viewpoint of the effect of sufficient warming can be obtained from warming composition, preferably polyethylene glycol.In addition, As polyethylene glycol, it is preferably 1000 polyethylene glycol below containing average molecular weight, average molecular weight also can be used together Polyethylene glycol greater than 1000.

In 100 mass % of warming composition, the content of polyalcohol is usually 30~99 mass %, and lower limit is preferably 40 matter Measure % or more, more preferably 50 mass % or more, in addition, the upper limit be preferably 97 mass % hereinafter, more preferably 95 mass % with Under.

In order to be dispersed stably in zeolite nanoparticle in warming composition, warming composition can also contain tackifier Or dispersing agent.

As the example of tackifier or dispersing agent, it is preferable to use natural polymer, synthesis macromolecule, surfactant, nothing Machine particle (inorganic substances and lamellar compound of micronized), specially xanthan gum, carbomer, nonionic surfactant, Fumed silica (fumed silica).These tackifier or dispersing agent can be used alone, can also by two kinds with Upper combination carry out using.Tackifier can be hydrophily, can also be hydrophobicity.

In 100 mass % of warming composition, the content of tackifier or dispersing agent is usually 0.01~20 mass %, lower limit Preferably 0.1 mass % or more, more preferably 0.5 mass % or more, in addition, the upper limit is preferably 15 mass % hereinafter, more preferably For 10 mass % or less.

In addition, being set as 20 DEG C and using Brookfield viscometer to sample for the viscosity of the warming composition after preparation The value being measured is usually 1~100000mPas, and lower limit is preferably 100mPas or more, more preferably 1000mPas More than, in addition, the upper limit is preferably 70000mPas hereinafter, more preferably 50000mPas or less.

It should be noted that it is preferable to use fumed silicas for tackifier in the case where polyalcohol uses polyethylene glycol. Fumed silica can be hydrophily, can also be hydrophobicity.

The preparation method of warming composition is not particularly limited, and is conventionally prepared.That is, with above-mentioned note The ratio of load puts into polyalcohol, tackifier etc. into dissolution kettle, and carrying out heating makes its uniform dissolution, forms gel.Then, it connects Investment mixing dispersion as the plastochondria of principal component and carried out using zeolite nanoparticle, make into split-phase and homogenize, composition is made.

For composition of the filling into aerosol preparation, desired discharge rate in order to obtain, separately Outside, in order to maintain good dispersibility for a long time in the composition containing powder, preferably there is the viscosity of appropriateness.The inventors of the present invention Have found new problem, that is, make in the present invention it is preferable to use polyethylene glycol thickening be very difficult.In order to solve this problem and It has made intensive studies, as a result, contemplating: the tackifier fumed silica for viscosifying polyethylene glycol sufficiently.It can recognize For fully improving viscosity this opinion by the way that fumed silica is incorporated into polyethylene glycol can be applied not only to this hair Bright warming composition, additionally it is possible to be widely applicable for the composition containing polyethylene glycol.

That is, another embodiment of the present invention is the thickening method of the composition containing polyethylene glycol, being includes addition The method of the process of fumed silica.

In this embodiment, the PEG content in composition is usually 10 mass % or more, preferably 30 mass % with On, more preferably 50 mass % or more.

The average grain diameter of fumed silica used in present embodiment is usually 5~50nm, it is preferable to use 10~ The fumed silica of 30nm.It should be noted that average grain diameter is the value determined using transmission electron microscope.

It is commercially available to have the (Japan of AEROSIL (registered trademark) 200 as the example for the fumed silica for meeting these physical property AEROSIL society system).

It, will be as the first chamber of warming composition and/or extremely in aerosol preparation alternatively Few second chamber containing water is filled to discharge container.In order to assign the viscosity of filled composition appropriateness, can make to Few second chamber containing water further contains the tackifier such as esters, water-soluble polymer.

Especially in the case where being suitable for human body use, esters make as moisturizer or emollient (emollient) etc. It is played a role with sense modifying agent etc..

It as esters, such as can enumerate: ethyl linoleate, isopropyl myristate, isopropyl palmitate, isostearic acid Isopropyl ester, lanolin fatty isopropyl propionate, the own ester of lanoceric acid, myristyl myristate, lactic acid cetyl ester, nutmeg It is sour octyldodecyl, decyl oleate, octyldodecyl oleate, Cetyl octanoate, dioctyl succinate, three pungent Acid glyceride, three glyceryl isostearates, two sad propylene glycol esters, ethyl oleate, cetyl palmitate, three (capryl/ Capric acid) high-grade aliphatic esters such as glyceride.These esters can be used alone, and two or more combinations can also be made With.

It as water-soluble polymer, can enumerate: guar gum, carrageenan, xanthan gum, glucan, hyaluronic acid, bright The natural polymers such as glue, casein, albumin, collagen, alginate；Polyvinyl alcohol, polyvinylpyrrolidone, carboxyl second Alkenyl polymer, (methyl) acrylic acid series polymeric compounds, cellulose-based polymer etc. synthesize macromolecule.These water-soluble polymers can One kind is used alone, two or more combinations can also be carried out using.

In 100 mass % of second chamber, the content of the tackifier in second chamber is usually 0.01~10 matter Measure %, preferably 0.05~5 mass %, more preferably 0.1~3 mass %.

The content of tackifier in second chamber within the above range in the case where, especially be suitable for human body use When, sticky feeling etc. will not be generated, good use feeling can be obtained.

Second chamber at least contains water, in addition to this, can also contain the alcohol such as ethyl alcohol, normal propyl alcohol, isopropanol, butanol.

In another embodiment, so that the purpose of skin moisture-keeping, first chamber can also be made, in second chamber Either one or both contains oil components.

As oil components, can example go out: the oil such as olive oil, soybean oil, sesame oil, rapeseed oil, avocado oil, castor oil Rouge；The waxes such as beeswax, Brazil wax, SIMMONDSIA CHINENSIS SEED OIL；Hexadecanol, stearyl alcohol, oleyl alcohol, docosyl alcohol, laruyl alcohol, myristyl alcohol are contour Grade alcohol；The hydrocarbon such as paraffin, polyisobutene, saualane, vaseline；Lauric acid, myristic acid, palmitinic acid, stearic acid, oleic acid etc. are advanced Fatty acid；The esters such as adipic acid isopropyl ester, isopropyl myristate, geoceric acid stearyl alcohol ester, isopropyl palmitate；The poly- silicon of dimethyl The organosilicons such as oxygen alkane, methyl phenyl silicone, Siloxane-Oxyalkylene Copolymers, alkyl-modified polysiloxanes；Ethylene glycol, glycerol etc. Polyalcohol.

In addition to this, also can according to need, make first chamber, either in second chamber or two sides contain it is anti- Rotten agent, stabilization agent, pH regulator, antioxidant, chelating agent, excipient, fragrance, UV resistant agent, moisturizer, surface-active Agent, other pyrogens (such as pepper extract or magnesium sulfate) etc..

In the present embodiment, the dosage form of first chamber and second chamber is not particularly limited, and uses in cosmetic preparation In the case where way, from the viewpoint of playing its effect, preferably gel dosage form or creams dosage form.First chamber, second group Conjunction object also can according to need to be emulsified using well known surfactant.

In addition, the container of filling warming composition is able to use well known container.Specifically, be able to use pipe, pump, Aerosol container etc..

Fig. 1 be second or the 4th embodiment aerosol preparation schematic front view.Aerosol preparation 100 is having shell It is stored in the discharge container of body 4 and output mechanism 5 and is sealed with the first container 1 and second container 2.In the first container 1 Filled with the first chamber at least containing zeolite nanoparticle, in addition, in second container 2 filled at least containing water second Composition.In discharge container, space 3 is formed between shell 4 and the first container 1 and second container 2, in the space 3 Filled with the stock solution for first chamber and second chamber to be discharged from output mechanism 5.Output mechanism 5 is respectively provided with Will be filled in the first container 1 and second container 2 composition discharge outlet, from outlet be discharged first chamber and The second chamber contact, thus, it is possible to form the warming composition of heat production.

Fig. 2 be second or the 4th embodiment aerosol preparation schematic front view.Aerosol preparation 200 is by having One outer container 11b, the second outer container 12b and have output mechanism 15 lid 16 aerosol component (aerosol set) It constitutes.The first content 11a is accommodated in first outer container 11b, and filled at least containing average in the first content 11a Partial size is the first chamber of 500nm zeolite nanoparticle below.It is accommodated with second inner container 12a in second outer container 12b, And filled at least containing the second chamber of water in second inner container 12a.In aerosol component, in the first outer container Space is respectively formed between 11b and the first content 11a and between the second outer container 12b and second inner container 12a 13, filled with the stock solution for first chamber and second chamber to be discharged from output mechanism 15 in the space.Discharge Mechanism 15, which is respectively provided with, to be filled in the outlet of the composition discharge of the first content 11a and second inner container 12a, from row The first chamber and second chamber contact of discharge are exported, thus, it is possible to form warming composition.Hold outside described first Device and second outer container can be able to carry out dismounting relative to the lid.Make lid and the first outer container and/or second Outer container is able to carry out dismounting, the feelings that the surplus of the composition in the container of outer container for being accommodated in a side tails off as a result, Under condition, it is able to carry out replacement.

Fig. 3 is the schematic front view of the aerosol preparation of third embodiment.For aerosol preparation 300, as The first content 11a of folding flexible bag (bag) is packaged on the opening portion of the downside of output mechanism 25, is restricted or prevented Be filled in the first content is at least the first chamber and presence of 500nm zeolite nanoparticle below containing average grain diameter In the mixing of the moisture in the outside of the first content 11a.It is formed between the first outer container 11b and the first content 11a free Between 23, filled with the stock solution for first chamber to be discharged from output mechanism 25 in the space.Output mechanism 25 has will The outlet for being filled in the composition discharge of the first content 11a is generated in valve working towards the flow path outside sack.It is logical The pressure from the stock solution being configured between the first content 11a and the first outer container 11b is crossed, generates and is directed to the first content The pressurization of 11a, the first chamber filled are discharged to outside the first outer container 11b.The first chamber being discharged be present in Contact with moisture in air or on the skin of human body, thus, it is possible to form warming composition.Present embodiment is commonly referred to as capsule Valve (bag-on-valve) or capsule tank (bag-in-can), such as can be used when distributing gel composition.Capsule valve is used Aerosol preparation which kind of angle no matter can similarly be discharged the content of sack from, can be whole by 99% content Discharge.

The stock solution being filled in discharge container or aerosol container is not particularly limited, and liquefied gas can be used, can also To use compressed gas.The aerosol preparation of present embodiment be by by first chamber and second chamber from discharge container Or therefore aerosol container discharge, the preparation for contacting them and generating heat are not necessarily required to be mixed after the exit, The flammable liquefied gas such as liquefied petroleum gas, dimethyl ether can be used as stock solution, but it is preferable to use highly-safe compressed gas.

Compressed gas is not particularly limited, as described above, considering the gas, it is preferable to use non-combustible from a security point Body.Specifically, can enumerate: carbon dioxide, nitrogen, nitrous oxide etc..

In the present embodiment, output mechanism is not particularly limited, it is preferred that can be by first chamber and second The structure that composition is discharged simultaneously with desired amount.Furthermore it is possible to output mechanism outlet be hung on net etc., so as to Water when contacting first chamber with second chamber contained by second chamber is sufficiently mixed with zeolite nanoparticle.

Such warming creams composition formation aerosol product of the invention can be used in various uses, especially exist Extremely good warming effect is played when suitable for human body, therefore is suitable as human body use.

Specifically, can be used as the comb such as the cosmetic preparations such as cosmetic cream, face film agent and foundation cream, shaving cream, Cleansing Foam Adornment (toiletry) articles.