阅读说明：本技术 低温导管和低温控制系统 (Cryogenic catheter and low-temperature control system ) 是由 吉训明 李明 尹志臣 丁玉川 姜缪文 高原 吴川杰 吴隆飞 鲍路姿 于 2019-08-26 设计创作，主要内容包括：本发明提供了一种低温导管和低温控制系统,低温导管包括导管本体(10),导管本体(10)内形成有并行的第一管道(11)、第二管道(12)、回流管道(13),导管本体(10)的一端形成有吸热腔(14),第一管道(11)、第二管道(12)以及回流管道(13)均与吸热腔(14)连通；第一管道(11)用于输送第一反应液,第二管道(12)用于输送第二反应液,第一反应液和第二反应液在吸热腔(14)混合后经回流管道(13)回流,第一反应液和第二反应液混合后能够发生吸热反应。由于只有在第一反应液和第二反应液混合后才能发生吸热反应,所以该低温导管只在导管的吸热腔产生低温区域；从而减少了对血管壁的刺激,降低了血管痉挛发生的可能。(The present invention provides a kind of cryogenic catheter and low-temperature control systems, cryogenic catheter includes catheter body (10), parallel first pipe (11), second pipe (12), reflux line (13) are formed in catheter body (10), one end of catheter body (10) is formed with heat-absorbing chamber (14), and first pipe (11), second pipe (12) and reflux line (13) are connected to heat-absorbing chamber (14)；First pipe (11) is for conveying the first reaction solution, second pipe (12) is for conveying the second reaction solution, first reaction solution and the second reaction solution flow back after heat-absorbing chamber (14) mix through reflux line (13), and the endothermic reaction can occur after the first reaction solution and the mixing of the second reaction solution.Since the endothermic reaction only could occur after the first reaction solution and the mixing of the second reaction solution, so the cryogenic catheter only generates low-temperature region in the heat-absorbing chamber of conduit；To reduce the stimulation to vascular wall, the possibility of vasopasm generation is reduced.)

1. a kind of cryogenic catheter, which is characterized in that including catheter body (10), be formed in the catheter body (10) parallel One end of first pipe (11), second pipe (12), reflux line (13), the catheter body (10) is formed with heat-absorbing chamber (14), the first pipe (11), second pipe (12) and reflux line (13) are connected to the heat-absorbing chamber (14)；

The first pipe (11) is for conveying the first reaction solution, and the second pipe (12) is for conveying the second reaction solution, institute The first reaction solution and second reaction solution is stated to flow back after the heat-absorbing chamber (14) mixing through the reflux line (13), it is described The endothermic reaction can occur after first reaction solution and second reaction solution mixing.

2. cryogenic catheter according to claim 1, which is characterized in that the first pipe (11) and the second pipe (12) the first one-way flow unit (111) and the second one-way flow unit (121) for preventing from flowing backwards are separately provided in.

3. cryogenic catheter according to claim 2, which is characterized in that the channel of the first one-way flow unit (111) Inner wall is formed with multiple flexible first valves (112), and the edges of multiple first valves (112) is to place channel Center extends and presses together, and the extending direction of multiple first valves (112) and the circulating direction in place channel tilt；

The vias inner walls of the second one-way flow unit (121) are formed with multiple flexible second valves (122), multiple The edge of second valve (122) extends and presses together to the center in place channel, multiple second valves (122) Extending direction and place channel circulating direction tilt.

4. cryogenic catheter according to claim 1, which is characterized in that the cross section of the catheter body (10) is circle, The cross section of the first pipe (11) and the second pipe (12) is shuttle shape, and the reflux line (13) is described first Gap between pipeline (11) and the second pipe (12).

5. cryogenic catheter according to claim 1, which is characterized in that the cross section of the catheter body (10) is circle, The cross section of the first pipe (11), second pipe (12) and reflux line (13) is circle.

6. a kind of low-temperature control system characterized by comprising cryogenic catheter as described in claim 1-5 any one, with First reaction liquid injection system (20) of first pipe (11) connection is reacted with the second of the second pipe (12) connection Liquid injection system (30) and the mixed liquor recovery system (40) being connected to the reflux line (13).

7. low-temperature control system according to claim 6, which is characterized in that further include: turn-key system (50) and temperature prison It surveys device (61), the temperature monitoring device (61) is used to monitor the temperature in the heat-absorbing chamber (14), first reaction solution Injected system (20), the second reaction liquid injection system (30) and temperature monitoring device (61) are electric with the turn-key system (50) Connection, the turn-key system (50) can control first reaction solution according to the monitoring data of the temperature monitoring device (61) The injection flow of injected system (20) and second reaction liquid injection system (30).

8. low-temperature control system according to claim 7, which is characterized in that further include: flow monitoring device (62), it is described Turn-key system (50) is electrically connected with the flow monitoring device (62), and the flow monitoring device (62) is for monitoring described first The injection flow of liquid injection system (20) and second reaction liquid injection system (30) is reacted, and will test data feedback to institute State turn-key system (50).

9. low-temperature control system according to claim 8, which is characterized in that further include: pressure monitoring device (63), it is described Turn-key system (50) is electrically connected with the pressure monitoring device (63), and the pressure monitoring device (63) is for monitoring described first Pressure in pipeline (11), the second pipe (12) and the reflux line (13), and will test data feedback to described Turn-key system (50), the turn-key system (50) can cut off the first reaction solution note when testing result reaches given threshold Enter system (20) and second reaction liquid injection system (30).

10. low-temperature control system according to claim 6, which is characterized in that first reaction liquid injection system (20) For injecting glycerin chlorination ammonium suspension, second reaction liquid injection system (30) is for injecting water.

Technical field

The present invention relates to medical instruments fields, and in particular to a kind of cryogenic catheter and low-temperature control system.

Background technique

Acute ischemic cerebral apoplexy is a kind of common disease, and disability rate and the death rate are high.2015, it is published in New England The multinomial large-scale clinical study results of medical journal confirm, for patients with acute ischemic stroke caused by vessel occlusion, blood Treatment is better than simple medication in pipe.However, due to the strictly equal limitation of endovascular treatment indication, it is clinically practical to receive The Proportion of patients of revascularization treatment is very limited.In addition, statistics indicate that, even if receiving effective revascularization treatment, patient The ratio of postoperative 90 days functional independences is less than 50%, and the death rate is still up to 15% or so.The reason of leading to this phenomenon and blood Reperfusion injury after Guan Zaitong is related, may cause the brain edema even generation of cerebral hemorrhage, endangers the life security of patient.

Mild hypothermia therapy is a kind of potent neuroprotection mode.It can be by reducing brain metabolism, inhibiting inflammatory reaction hair The mechanisms plays neuroprotection such as raw and Apoptosis and protection blood-brain barrier.Therefore, it is proposed that by endovascular treatment The theory that technology and Mild Hypothermal neuroprotection combine, to improve endovascular treatment effect, mitigate reperfusion injury, to make soldier Middle patient benefits.

Existing technology mainly has: intravascular low temperature is realized by way of cryogenic catheter, it is main at present low by being perfused The mode of warm coolant liquid is implemented.Major technique are as follows: be inserted into Research of Intravascular Catheterization from Human Femoral Artery, be passed through inside interposing catheter Perfusion liquid is imported the intra-arterial in cerebral infarction dead zone by conduit, to reach the mesh of cooling by 4 DEG C or so of hypothermia perfusion liquid 's.

From the point of view of the above-mentioned prior art, there are mainly two types of the technologies that improve cooling effect: cryogenic fluid perfusion technique and Hot-bulb capsule heat transfer technology, the two to cooling have the shortcomings that it is respective, it is specific as follows:

(1) since conduit heat-proof quality used is poor, two kinds of technologies all undesirably increase other than the cerebrovascular with lead The cooling risk of pipe contact-segment blood vessel increases and does not need the blood vessel of cooling and be cooled the risks of the complication such as spasm.So this is specially Benefit proposes a kind of temperature flow based on the endothermic reaction from response controllable type mild hypothermia therapy conduit, and the advantages of the method is When conduit is inserted into arteria carotis from femoral artery, the endothermic reaction only occurs in catheter head, remaining region applies without continuous external to drop Temperature can keep conduit temperature and vascular wall temperature close.

(2) compared to more hot-bulb capsule heat transfer technologies, hot-bulb capsule exchanges heat, and often conduit diameter is larger (because of cladding for cryogenic catheter Multiple sacculus) it is excessive so as to cause conduit diameter, such catheter position is limited to can be only inserted into main artery blood vessel, further results in Too far apart from cerebral infarction dead zone, such low temperature blood flow is easily neutralized that cooling effect is not achieved cooling initial point.This patent saves Slightly hot balloons technique, both reduces difficulty of processing, it is also possible that catheter head realizes that size is smaller, it is relatively thin so as to protrude into Blood vessel in, improve cooling effect.

(3) brain tissue is very sensitive to temperature change, and low temperature can be such that the oxygen requirement of brain cell reduces, and maintains the supply and demand of brain oxygen flat Weighing apparatus, plays cerebral protection, is the important component of cerebral resuscitation complex treatment.Every l DEG C of the reduction of body temperature can be such that metabolic rate declines 5%~6%.Therefore realize that the precisely cooling in cerebral infarction dead zone is significant.However at present although office may be implemented in cryogenic catheter Portion's cooling purpose, but the temperature of target area cannot achieve and be precisely controlled.

Summary of the invention

The object of the present invention is to provide a kind of cryogenic catheter and low-temperature control systems, to solve at least one in background technique A technical problem.

To achieve the goals above, present invention firstly provides a kind of cryogenic catheter, including catheter body, the catheter bodies It is inside formed with parallel first pipe, second pipe, reflux line, one end of the catheter body is formed with heat-absorbing chamber, described First pipe, second pipe and reflux line are connected to the heat-absorbing chamber；

The first pipe is for conveying the first reaction solution, and the second pipe is for conveying the second reaction solution, and described the One reaction solution and second reaction solution flow back after heat-absorbing chamber mixing through the reflux line, first reaction solution and The endothermic reaction can occur after the second reaction solution mixing.

Optionally, the first one-way flow for preventing from flowing backwards is separately provided in the first pipe and the second pipe Moving cell and the second one-way flow unit.

Optionally, the vias inner walls of the first one-way flow unit are formed with multiple flexible first valves, more The edge of a first valve extends and presses together to the center in place channel, the extension side of multiple first valves It is tilted to the circulating direction in place channel；

The vias inner walls of the second one-way flow unit are formed with multiple flexible second valves, and multiple described The edge of two valves extends and presses together to the center in place channel, the extending direction of multiple second valves and place The circulating direction in channel tilts.

Optionally, the cross section of the catheter body is circle, the cross section of the first pipe and the second pipe It is shuttle shape, gap of the reflux line between the first pipe and the second pipe.

Optionally, the cross section of the catheter body is circle, the first pipe, second pipe and reflux line Cross section is circle.

Another aspect of the present invention provides a kind of low-temperature control system, comprising: cryogenic catheter provided by the invention, with described First reaction liquid injection system of one pipeline connection, reacts liquid injection system, Yi Jiyu with the second of second pipe connection The mixed liquor recovery system of the reflux line connection.

Optionally, further includes: turn-key system and temperature monitoring device, the temperature monitoring device is for monitoring the heat absorption Intracavitary temperature, it is described first reaction liquid injection system, second reaction liquid injection system and temperature monitoring device with it is described Turn-key system electrical connection, the turn-key system can control first reaction according to the monitoring data of the temperature monitoring device The injection flow of liquid injection system and the second reaction liquid injection system.

Optionally, further includes: flow monitoring device, the turn-key system is electrically connected with the flow monitoring device, described Flow monitoring device is used to monitor the injection flow of the first reaction liquid injection system and the second reaction liquid injection system, And it will test data feedback to the turn-key system.

Optionally, further includes: pressure monitoring device, the turn-key system is electrically connected with the pressure monitoring device, described Pressure monitoring device is used to monitor the pressure in the first pipe, the second pipe and the reflux line, and will inspection Measured data feeds back to the turn-key system, and the turn-key system can cut off described first when testing result reaches given threshold React liquid injection system and the second reaction liquid injection system.

Optionally, the first reaction liquid injection system is for injecting glycerin chlorination ammonium suspension, second reaction solution Injected system is for injecting water.

Cryogenic catheter provided by the invention, due to could only be inhaled after the first reaction solution and the mixing of the second reaction solution Thermal response, so the cryogenic catheter only generates low-temperature region in the heat-absorbing chamber of conduit；To reduce the stimulation to vascular wall, drop The possibility that low vasopasm occurs.

Detailed description of the invention

Fig. 1 is the overall schematic of cryogenic catheter in embodiment of the present invention；

Fig. 2 is the stereoscopic schematic diagram of cryogenic catheter in the embodiment of the present invention one；

Fig. 3 is the cross-sectional view of cryogenic catheter in Fig. 2；

Fig. 4 be in Fig. 3 cryogenic catheter along the schematic cross-section in the direction A-A；

Fig. 5 is the stereoscopic schematic diagram of cryogenic catheter in the embodiment of the present invention two；

Fig. 6 is the cross-sectional view of cryogenic catheter in Fig. 5；

Fig. 7 be in Fig. 6 cryogenic catheter along the schematic cross-section in the direction B-B；

Fig. 8 is the schematic diagram of low-temperature control system in embodiment of the present invention.

Appended drawing reference:

10- catheter body；11- first pipe；111- the first one-way flow unit；The first valve of 112-；12- second is managed Road；121- the second one-way flow unit；The second valve of 122-；

13- reflux line；14- heat-absorbing chamber；

20- first reacts liquid injection system；

30- second reacts liquid injection system；

40- mixed liquor recovery system；

50- turn-key system；

61- temperature monitoring device；62- flow monitoring device；63- pressure monitoring device.

Specific embodiment

To better understand the objects, features and advantages of the present invention, with reference to the accompanying drawings and examples The present invention is described in further detail.It is understood that described embodiment is a part of the embodiments of the present invention, Instead of all the embodiments.Specific embodiment described herein is used only for explaining the present invention, rather than to limit of the invention It is fixed.Based on described the embodiment of the present invention, those of ordinary skill in the art's every other embodiment obtained is belonged to The scope of protection of the invention.

Technology involved in present embodiment is the cryogenic catheter design in the protection of Mild Hypothermal brain, and the purpose is in cerebral infarction Region forms topically effective low temperature environment, the Mild Hypothermal range for making the tissue temperature at cerebral infarction be down to 30~35 DEG C, to reach To the temperature requirement of mild hypothermia therapy.