阅读说明：本技术 一种灭菌装置 (Sterilization device ) 是由 谢和兵 尼玛次仁 白玛旦增 于 2021-08-21 设计创作，主要内容包括：本发明公开了一种基于低温等离子体的灭菌装置,包括机体、气流循环管道、送风装置、灭菌介质蒸汽生成装置、空气净化装置以及真空装置,所述气流循环管道分为进气管道与出气管道,所述机体内部设有灭菌腔、等离子体发生装置以及流体网板。本发明可用于中药材饮片、粉剂或中药配方颗粒剂或中成药的灭菌,以解决现有中药材饮片、粉剂或中药配方颗粒剂或中成药灭菌技术中灭菌试剂易残留、耗能大、灭菌穿透力弱、容易破坏易氧化或不耐热成分、挥发性成分易逸散等问题。(The invention discloses a low-temperature plasma-based sterilization device, which comprises a machine body, an airflow circulating pipeline, an air supply device, a sterilization medium steam generation device, an air purification device and a vacuum device, wherein the airflow circulating pipeline is divided into an air inlet pipeline and an air outlet pipeline, and a sterilization cavity, a plasma generation device and a fluid screen plate are arranged in the machine body. The sterilization agent can be used for sterilizing traditional Chinese medicine decoction pieces, powder or traditional Chinese medicine formula granules or traditional Chinese medicines, and solves the problems that sterilization reagents in the traditional Chinese medicine decoction pieces, powder or traditional Chinese medicine formula granules or traditional Chinese medicines sterilization technology are easy to remain, energy consumption is large, sterilization penetrating power is weak, easily-oxidized or thermolabile components are easy to damage, volatile components are easy to dissipate and the like.)

1. A sterilization device, includes the organism, its characterized in that: the machine body is internally provided with a sterilization cavity, a plasma generating device and a fluid screen plate, and the fluid screen plate is arranged between the sterilization cavity and the plasma generating device.

2. A sterilization apparatus according to claim 1, characterized in that: the machine body is characterized in that a feeding hole and a discharging hole are formed in the upper end and the lower end of the machine body respectively, a feeding baffle is arranged between the feeding hole and the sterilization cavity, and a discharging baffle is arranged between the discharging hole and the sterilization cavity.

3. A sterilization apparatus according to claim 1, characterized in that: including air current circulating line and air supply arrangement, air current circulating line divide into admission line and pipeline of giving vent to anger, admission line connects between plasma generating device and air supply arrangement, the pipeline of giving vent to anger is connected between sterilization chamber top and air supply arrangement, and the junction is equipped with dustproof otter board.

4. A sterilization apparatus according to claim 3, characterized in that: comprises a sterilization medium steam generating device which is connected with an air inlet pipeline.

5. A sterilization apparatus according to claim 3 or 4, characterized in that: the air purification device is connected with the air supply device, an air inlet valve is arranged at the joint, the vacuum device is connected with the sterilization cavity, and a vacuum valve and a dustproof screen plate are arranged at the joint.

Technical Field

The invention belongs to the technical field of sterilization equipment, and particularly relates to a sterilization device based on low-temperature plasma, which can be used for sterilizing traditional Chinese medicine decoction pieces, powder or traditional Chinese medicine formula granules or traditional Chinese medicines.

Background

The sterilization is to reduce the residual probability of the contaminated microorganisms in the articles to a certain level by a physical or chemical method so as to ensure the sterility of the articles. In the modern production of traditional Chinese medicinal materials, the raw powder is used as a common processing technology in the production of Chinese patent medicines, health-care foods and the like. The Chinese medicinal granule is a dosage form which is convenient to carry and take and is prepared by specially processing Chinese medicinal materials according to the Chinese medicinal theory and clinical application requirements. The Chinese medicinal granule can also be an intermediate for Chinese patent medicine production.

For traditional Chinese medicine decoction pieces, powder or traditional Chinese medicine formula granules, microbiological examination is carried out, the traditional Chinese medicine preparation can be used as a medicine according with the requirement of microbial limit, and the traditional Chinese medicine preparation including Tibetan medicine is sold in the market according with the requirement of microbial limit. Therefore, the sterilization operation is an important link in the production process of the traditional Chinese medicine decoction pieces, the powder or the traditional Chinese medicine formula granules or the traditional Chinese medicine. The currently commonly used sterilization methods include ethylene oxide sterilization, ozone sterilization, ultraviolet sterilization, microwave sterilization, superheated steam sterilization, dry heat sterilization, and microwave sterilization,⁶⁰Co-gamma irradiation sterilization method.

Because the traditional Chinese medicine components are complex, the methods have some defects, such as: ethylene oxide is flammable and explosive for sterilization, residues can cause product variation, and the application in the aspect of medicine production is limited. Ozone sterilization is not suitable for sterilization of easily oxidizable species because it has weak penetration, and its temperature and humidity also affect the sterilization effect. Ultraviolet rays have weak penetrating power and can only be used for sterilizing air and object surfaces. The microwave sterilization method has the advantages that the sterilization effect is easily influenced by the water content of the materials, and is not suitable for medicinal materials and medicinal powder with low water content and materials containing heat-sensitive components. The superheated steam sterilization method is easy to solidify or denature protein, and easily causes degradation of heat-sensitive traditional Chinese medicine components, thereby causing reduction of curative effect or generation of toxic and side effects. The dry heat sterilization method is easy to cause the color of the medicinal powder to become dark, block and cause the dissipation of volatile components, and the medicinal fine powder containing volatile oil components and sugar or grease components in high proportion is not suitable for the dry heat sterilization method. 60 Co-gamma has residue, which affects the safety of the medicine.

Plasma refers to minute particles generated by ionization of gas under the action of energetic particles generated by a specific device, and highly ionized gas consisting of free electrons, anions and cations, atoms and molecules in a ground state or an excited state, various free radicals, an electromagnetic field, and photons. The number of positive and negative charges of the minute particles are exactly equal, so the overall particles behave electrically neutral and are therefore called plasma. The plasma may be generated in a low pressure, atmospheric pressure, high pressure environment. The plasma can be further classified into a high temperature plasma and a low temperature plasma according to the temperature of the excited electrons. Currently, the sterilization plasma used in the food industry and the medical industry is generally a low temperature plasma. The generation method includes Dielectric Barrier Discharge (DBD), Atmospheric Pressure Plasma Jet (APPJ), corona discharge, sliding arc discharge, microwave discharge, glow discharge, corona discharge plasma jet, etc. Among them, the devices used by the DBD and the APPJ are common because of their simple structure and easy modification.

The mechanism of the low-temperature plasma for generating the sterilization effect mainly comprises the effects of UV, pH, an electric field, high-speed electrons, active oxygen, active nitrogen and other sterilization substances. Research shows that the surfaces of the bacterial and viral membranes are positively charged, the normal distribution of charges on the membranes is beneficial to the absorption of bacteria and viruses on nutrient substances, but when the charges on the membranes are interfered by charged particles, the charges on the membranes cannot be normally distributed, and the death of the bacteria and the viruses caused by the normal physiological activities of the bacteria and the viruses is further broken. Active particles in the plasma impact the microbial cell membrane, and when the quantity of the active particles reaches a certain number, the active particles can penetrate the cell membrane and chemically react with substances such as protein and nucleic acid in the cell to destroy the electrolyte balance of the cell, and even penetrate into the cell to puncture the cell nucleus to cause cell death. Particle action generated in the plasma field may volatilize leaking proteins and nucleic acids. In addition, ultraviolet rays are generated during the generation of plasma, and nucleic acids are destroyed by absorbing such high-energy ultraviolet photons.

The low-temperature plasma sterilization technology is widely applied to sterilization and disinfection of medical instruments at present, and has been widely researched in a laboratory scale as a novel non-thermal sterilization technology in the field of food sterilization. The low-temperature plasma sterilization technology can meet the sterilization requirements of traditional Chinese medicine decoction pieces, powder or traditional Chinese medicine formula granules or traditional Chinese medicines, and has the advantages of low energy consumption, environmental protection and wide application range.

Disclosure of Invention

The invention discloses a low-temperature plasma-based sterilization device which can be used for sterilizing traditional Chinese medicine decoction pieces, powder or traditional Chinese medicine formula granules or traditional Chinese medicines, and solves the problems that sterilization reagents in the traditional Chinese medicine decoction pieces, powder or traditional Chinese medicine formula granules or traditional Chinese medicines sterilization technology are easy to remain, large in energy consumption, weak in sterilization penetrating power, easy to damage easily-oxidized or thermolabile components, easy to dissipate volatile components and the like.

The specific technical scheme is as follows: a sterilization device comprises a machine body, wherein a sterilization cavity, a plasma generation device and a fluid mesh plate are arranged in the machine body, the fluid mesh plate has air permeability, is arranged between the sterilization cavity and the plasma generation device, and is used for containing Chinese medicinal decoction pieces, powder or Chinese medicinal formula granules or Chinese patent medicaments in the sterilization process. The plasma generating device adopts an atmospheric pressure low-temperature plasma jet array form and comprises a discharging assembly and a plasma generator, wherein the discharging assembly is connected with the plasma generator. The plasma plume generated by the plasma generating device can enter the Chinese medicinal decoction pieces, powder or Chinese medicinal formula granules or Chinese patent medicines through the fluid mesh plate to play a role in sterilization.

Further, the upper end and the lower end of the machine body of the sterilization device are respectively provided with a feeding hole and a discharging hole, a feeding baffle is arranged between the feeding hole and the sterilization cavity, and a discharging baffle is arranged between the discharging hole and the sterilization cavity. The feeding baffle and the discharging baffle can control feeding and discharging respectively, and both have the function of sealing the sterilization cavity.

Further, sterilization apparatus includes air current circulating line and air supply arrangement, air current circulating line divide into admission line and pipeline of giving vent to anger, admission line connects between plasma generating device and air supply arrangement, the pipeline of giving vent to anger is connected between sterilization chamber top and air supply arrangement, and the junction is equipped with dustproof otter board. In the sterilization process, the air supply device provides high-speed airflow to the air inlet pipeline, the airflow passes through the plasma generating device and sends the generated plasma into the sterilization cavity, and the airflow in the sterilization cavity enters the air supply device through the air outlet pipeline, so that the airflow containing the plasma is in a high-speed circulation state and continuously passes through the traditional Chinese medicine decoction pieces, the powder or the traditional Chinese medicine formula granules or the traditional Chinese medicine. In the process, the Chinese medicinal decoction pieces, powder, Chinese medicinal granule or Chinese medicinal herb are subjected to high-speed circulating airflow to maintain fluidization state.

Further, the sterilization device comprises a sterilization medium steam generation device, and the sterilization medium steam generation device is connected with the air inlet pipeline. The sterilizing medium steam generating device vaporizes a sterilizing medium (such as hydrogen peroxide) and then leads the vaporized sterilizing medium into the air inlet pipeline, and the sterilizing medium steam is excited into plasma through the plasma generating device, so that the plasma concentration in the circulating air flow is improved, and the sterilizing efficiency is further improved.

Further, the sterilization device comprises an air purification device and a vacuum device, the air purification device is connected with the air supply device, an air inlet valve is arranged at the joint, the vacuum device is connected with the sterilization cavity, and a vacuum valve is arranged at the joint. Before sterilization, residual solvent in Chinese medicinal decoction pieces, powder or Chinese medicinal granule or Chinese patent medicine can be removed by a vacuum device and an air purification device, and the air in the sterilization cavity is kept pure. After sterilization, residual sterilization medium steam in the sterilization cavity can be removed through a vacuum device and an air purification device.

Compared with the prior art, the invention has the following beneficial effects:

1. the invention provides a low-temperature plasma-based sterilization device, which is characterized in that a plasma generator is used for exciting active particles containing various ions, such as free radicals, photons, electrons, excited atoms, excited molecules and other high energy, ultraviolet light and the like, so as to sterilize traditional Chinese medicine decoction pieces, powder or traditional Chinese medicine formula granules or Chinese patent medicines, the whole process is non-toxic and harmless, the whole reaction system can be kept at a low temperature even close to the room temperature, and easily-oxidized components, thermolabile components or volatile components can not be damaged.

2. In the sterilization process, the traditional Chinese medicine decoction pieces, the powder or the traditional Chinese medicine formula granules or the traditional Chinese medicine is kept in a fluidized state under the action of the high-speed circulating airflow, the contact area and the contact time with the plasma are increased, and in addition, the circulating airflow continuously passes through the plasma generating device, so that the concentration of the plasma in the sterilization cavity is ensured to be in a saturated state, and the sterilization efficiency is improved.

3. The invention can select a sterilizing medium steam generating device to vaporize a sterilizing medium (such as hydrogen peroxide) and then introduce the vaporized sterilizing medium into the air inlet pipeline, thereby improving the plasma concentration in the circulating air flow and further improving the sterilizing efficiency.

4. By adjusting the using method of the invention, the continuous sterilization of the traditional Chinese medicine decoction pieces, the powder or the traditional Chinese medicine formula granules or the traditional Chinese patent medicine can be realized, and the production efficiency is improved.

Drawings

FIGS. 1 and 2 are schematic structural views of the present invention;

the figure is as follows: the device comprises a machine body 1, a sterilization cavity 11, a plasma generating device 12, a fluid screen plate 13, a feeding hole 2, a discharging hole 3, a feeding baffle 21, a discharging baffle 31, an air supply device 5, an air inlet pipeline 41, an air outlet pipeline 42, a dustproof screen plate 13, a dustproof screen plate 14, a sterilization medium steam generating device 7, an air purifying device 8, an air inlet valve 81, a vacuum device 9 and a vacuum valve 91.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention are described below in detail and completely with reference to the accompanying drawings and examples.

Example 1:

as shown in fig. 1, the embodiment discloses a sterilization device based on low-temperature plasma, which is used for sterilizing traditional Chinese medicine powder or traditional Chinese medicine granules, and comprises a machine body 1, an airflow circulating pipeline, an air supply device 5, a sterilization medium steam generating device 7, an air purifying device 8 and a vacuum device 9. The air circulation duct is divided into an inlet duct 41 and an outlet duct 42.

The machine body 1 is internally provided with a sterilization cavity 11, a plasma generating device 12 and a fluid mesh plate 13, wherein the fluid mesh plate 13 has air permeability and is arranged between the sterilization cavity 11 and the plasma generating device 12. The plasma generating device 12 is in the form of an atmospheric pressure low temperature plasma jet array and comprises a discharge assembly and a plasma generator, wherein the discharge assembly is connected with the plasma generator.

The upper end and the lower end of the machine body 1 are respectively provided with a feeding hole 2 and a discharging hole 3, a feeding baffle 21 is arranged between the feeding hole 2 and the sterilizing cavity 11, and a discharging baffle 31 is arranged between the discharging hole 3 and the sterilizing cavity 11. The feeding baffle plate 21 and the discharging baffle plate 31 can control feeding and discharging respectively and have the function of sealing the sterilization cavity 11.

The air inlet duct 41 is arranged between the plasma generating device 12 and the air supply device 5; the air outlet pipeline 42 is connected between the top end of the sterilization cavity 11 and the air supply device 5, and the connection part is provided with a dustproof mesh plate 13.

The sterilizing medium steam generating device 7 is connected with the air inlet pipeline 41; the air purification device 8 is connected with the air supply device 5, and an air inlet valve 81 is arranged at the joint; the vacuum device 9 is connected with the sterilization cavity 11, and a vacuum valve 91 and a dustproof mesh plate 14 are arranged at the connection position.

The using method of the embodiment comprises the following steps:

the method comprises the steps of putting traditional Chinese medicine decoction pieces, powder or traditional Chinese medicine formula granules or traditional Chinese medicines to be sterilized into a feed inlet 2, opening a feed baffle 21, opening an air supply device 5, enabling the air supply device 5 to provide high-speed airflow to an air inlet pipeline 41, enabling the airflow to pass through a plasma generation device 12, enter a sterilization cavity 11 through a fluid mesh plate 13, and finally enter the air supply device 5 through an air outlet pipeline 42, enabling the traditional Chinese medicine decoction pieces, the powder or the traditional Chinese medicine formula granules or the traditional Chinese medicines to enter the sterilization cavity 11 from the feed inlet 2 under the action of high-speed circulating airflow, and forming a fluidized state on the fluid mesh plate 13.

After the feeding is finished, the feeding baffle 21 is closed, the vacuum device 9, the vacuum valve 91, the air purification device 8 and the air inlet valve 81 are opened, and after residual solvents in the traditional Chinese medicine decoction pieces, the traditional Chinese medicine powder or the traditional Chinese medicine formula granules or the traditional Chinese medicine are removed, the vacuum device 9, the vacuum valve 91, the air purification device 8 and the air inlet valve 81 are closed.

The plasma generating device 12 is started, and the generated plasma plume repeatedly enters the traditional Chinese medicine decoction pieces, the powder or the traditional Chinese medicine formula granules or the traditional Chinese medicine interior along with the circulating airflow for sterilization. The sterilization medium steam generating device 7 is opened, hydrogen peroxide is used as the sterilization medium, and the hydrogen peroxide medium is vaporized and enters the plasma generating device 12 through the air inlet pipe 41 to be excited into plasma.

After sterilization, the sterilization medium steam generating device 7 and the plasma generating device 12 are closed, the vacuum device 9, the vacuum valve 91, the air purifying device 8 and the air inlet valve 81 are opened, after residual plasma gas in the sterilization cavity is removed, the discharge baffle plate 31 is opened, and the Chinese medicinal decoction pieces, the Chinese medicinal powder or the Chinese medicinal formula granules or the Chinese medicinal herbs leave the sterilization cavity 11 from the discharge hole 3 under the action of circulating air flow.

Example 2:

as shown in fig. 2, the present embodiment discloses a low-temperature plasma-based sterilization apparatus, which can continuously sterilize decoction pieces, powder, or granules or Chinese traditional medicine by adjusting the use method.

Comprises a machine body 1, an airflow circulating pipeline, an air supply device 5 and a sterilizing medium steam generating device 7. The air circulation duct is divided into an inlet duct 41 and an outlet duct 42.

The machine body 1 is internally provided with a sterilization cavity 11, a plasma generating device 12 and a fluid mesh plate 13, wherein the fluid mesh plate 13 has air permeability and is arranged between the sterilization cavity 11 and the plasma generating device 12. The plasma generating device 12 is in the form of an atmospheric pressure low temperature plasma jet array and comprises a discharge assembly and a plasma generator, wherein the discharge assembly is connected with the plasma generator.

The upper end and the lower end of the machine body 1 are respectively provided with a feeding hole 2 and a discharging hole 3, a feeding baffle 21 is arranged between the feeding hole 2 and the sterilizing cavity 11, and a discharging baffle 31 is arranged between the discharging hole 3 and the sterilizing cavity 11. The feeding baffle plate 21 and the discharging baffle plate 31 can control feeding and discharging respectively and have the function of sealing the sterilization cavity 11.

The air inlet duct 41 is arranged between the plasma generating device 12 and the air supply device 5; the air outlet pipeline 42 is connected between the top end of the sterilization cavity 11 and the air supply device 5, and the connection part is provided with a dustproof mesh plate 13. The sterilization medium steam generator 7 is connected to the air inlet duct 41.

The using method of the embodiment comprises the following steps:

the blower 5 is turned on, and the plasma generator 12 and the sterilizing medium steam generator 7 are started. The traditional Chinese medicine decoction pieces, the powder or the traditional Chinese medicine formula granules or the traditional Chinese medicine Chinese patent medicine to be sterilized are put into the feeding hole 2, the feeding baffle 21 and the discharging baffle 31 are opened, the traditional Chinese medicine decoction pieces, the powder or the traditional Chinese medicine formula granules or the traditional Chinese patent medicine enters the sterilizing cavity from the feeding hole 2 under the action of high-speed circulating airflow to form a fluidized state, and the traditional Chinese medicine decoction pieces, the powder or the traditional Chinese medicine formula granules or the traditional Chinese patent medicine enters the sterilizing cavity 11 from the discharging hole 3. In the next process, the plasma carried by the circulating air flow continuously passes through the Chinese medicinal decoction pieces, the powder or the Chinese medicinal formula granules or the Chinese patent medicines to finish sterilization. By controlling the blocking range of the feeding baffle plate 21 and the discharging baffle plate 31, the speed of Chinese medicinal decoction pieces, powder or Chinese medicinal granule or Chinese medicinal herb flowing through the sterilizing cavity 11 can be controlled, thereby ensuring the sterilizing time and effect.