阅读说明：本技术 一种药物代谢动力学采样和数据收集系统 (A kind of sampling of pharmacokinetics and data gathering system ) 是由 顾哲明 于 2018-05-25 设计创作，主要内容包括：本发明公开了一种药物代谢动力学采样和数据收集系统,包括采样室、离心电机和离心试管,所述离心试管的底部通过卡槽与转动盘的端面固定卡装,所述密封盖内部端面对应离心试管的顶部通过转动盖板固定设置有卡位座,所述转动盖板的周边通过转动盘与密封盖固定安装。该药物代谢动力学采样和数据收集系统,具备便于对采集受试者静脉血液后直接输出至离心设备内部对血浆离心操作,并对不同时段采集的血液信息明确区分,提高对药动力学数据收集的便捷性的优点,解决了现有对药动力学血浆采集后对血浆离心操作时需要中转,增加了血浆感染空气中细菌的几率,并且对血浆采集数据标示较为不便,易对采集血浆的数据混淆的问题。(The invention discloses a kind of sampling of pharmacokinetics and data gathering systems, including sampler chamber, centrifugation motor and centrifuge tube, the bottom of the centrifuge tube is clamped by the way that the end face of card slot and rotating disc is fixed, the top that the sealing cover internal end surface corresponds to centrifuge tube is fixedly installed detent seat by rotating plate, and the periphery of the rotating plate is fixedly mounted by rotating disc and sealing cover.Pharmacokinetics sampling and data gathering system, have and is convenient for being directly output to interior of centrifugal device to blood plasma centrifugally operated to after acquisition subject's venous blood, and the blood information of different periods acquisition is clearly distinguished, the advantages of convenience that medicine dynamics data is collected in raising, transfer is needed when solving after the existing dynamics sampled plasma to medicine to blood plasma centrifugally operated, increase the probability of bacterium in blood plasma infection air, and it is more inconvenient to sampled plasma data mark, easily to the data obfuscation of acquisition blood plasma the problem of.)

1. a kind of pharmacokinetics sampling and data gathering system, including sampler chamber (1), centrifugation motor (2) and centrifugation examination It manages (3), it is characterised in that: be fixedly installed with rotating disc (11) inside the sampler chamber (1), the end face of the rotating disc (11) is opened Equipped with card slot (31) corresponding with centrifuge tube (3) bottom, the bottom of the centrifuge tube (3) passes through card slot (31) and rotating disc (11) end face is fixed to be clamped, and is fixedly installed with sealing cover (13) at the top of the sampler chamber (1), the sealing cover (13) is internal The top that end face corresponds to centrifuge tube (3) is fixedly installed detent seat (132), the rotating plate by rotating plate (131) (131) it is fixedly mounted by rotating disc (133) and sealing cover (13), the end face of the sealing cover (13) corresponds to detent seat (132) Center offer through-hole (321), and be fixedly installed seal rubber plug (32) by through-hole (321), the sealing cover (13) End face is inlaid with the display screen (33) for touching structure, and the input terminal of the display screen (33) is electrically connected with processor (22), institute The input terminal for stating processor (22) is connected with input keyboard (221) and data statistics module (222), and the centrifugation motor (2) is solid Dingan County is mounted in the bottom of sampler chamber (1), and the input terminal of centrifugation motor (2) and the output end of processor (22) are electrically connected, The output end of centrifugation motor (2) is fixedly mounted by the bottom of output shaft (21) and rotating disc (11).

2. a kind of pharmacokinetics sampling according to claim 1 and data gathering system, it is characterised in that: described The bottom end face that the bottom of sampler chamber (1) corresponds to rotating disc (11) is provided with guiding axis (12), rotating disc (11) bottom end Face is fixedly mounted by guide holder (121) and guiding axis (12).

3. a kind of pharmacokinetics sampling according to claim 1 and data gathering system, it is characterised in that: described Sampler chamber (1) and centrifuge tube (3) are all made of transparent configuration setting, and the centrifuge tube (3) is distributed in by card slot (31) Sampler chamber (1) interior periphery.

4. a kind of pharmacokinetics sampling according to claim 1 and data gathering system, it is characterised in that: described The end face of seal rubber plug (32) is provided with time identifier plate (322).

5. a kind of pharmacokinetics sampling according to claim 1 and data gathering system, it is characterised in that: described Data statistics module (222) is statistical table software, and the output end of the processor (22) is electrically connected with data storage module (23), the input terminal of the data statistics module (222) passes through the output of data acquisition module (223) and input keyboard (221) End is electrically connected.

Technical field

The present invention relates to pharmacokinetic data acquisition technique field, specially a kind of pharmacokinetics samples sum number According to collection system.

Background technique

Pharmacokinetics mainly studies a science of the processing rule of drug in vivo, passes through principle of dynamics combination number Learn absorption, metabolism, distribution and the discharge process of drug after model quantitative study is taken medicine.Its research achievement can be used for that new drug is instructed to set Meter, improvement type, improves drug effect, reduces side effect Optimized Regimen.

Calculate the key data of pharmacokinetic parameter after being taken medicine in different time points blood plasma when the concentration of drug.Medicine The dynamic research object learned is divided into human body and animal.By taking kinesiology is studied as an example, key step is as follows: firstly, clinical doctor Subject's drug centainly measured is given according to dosage regimen is designed by institute, and then different time points acquire subject after administration Venous blood, centrifugal separation plasma is placed on to be posted in the test tube of label in advance, is placed in low temperature refrigerator and is saved, assay laboratory Detection blood plasma drug concentration simultaneously analyzes data.

After needing blood to be extracted by syringe after at present taking subject's venous blood and inject centrifuge tube inner part From blood plasma, easily lead to bacterium of blood during transfer in ingress of air, influences the acquisition quality to blood, and for Data after blood collection rely only on label and indicate to data, inconvenient to the information data collection of blood.

Summary of the invention

The purpose of the present invention is to provide a kind of sampling of pharmacokinetics and data gathering systems, have convenient for adopting Interior of centrifugal device is directly output to blood plasma centrifugally operated after collection subject's venous blood, and to the blood of different periods acquisition The advantages of information is clearly distinguished, and the convenience collected to medicine dynamics data is improved solves and existing adopts to medicine dynamics blood plasma Transfer is needed when after collection to blood plasma centrifugally operated, increases the probability of bacterium in blood plasma infection air, and to sampled plasma number It is more inconvenient according to mark, easily to the data obfuscation of acquisition blood plasma the problem of.

To achieve the above object, the invention provides the following technical scheme: a kind of sampling of pharmacokinetics and data are received Collecting system, including sampler chamber, centrifugation motor and centrifuge tube are fixedly installed with rotating disc, the rotation inside the sampler chamber The end face of disk offers card slot corresponding with centrifuge tube bottom, and the bottom of the centrifuge tube passes through the end of card slot and rotating disc Face is fixed to be clamped, and is fixedly installed with sealing cover at the top of the sampler chamber, the sealing cover internal end surface corresponds to centrifuge tube Top is fixedly installed detent seat by rotating plate, and the periphery of the rotating plate is pacified by the way that rotating disc and sealing cover are fixed Dress, the center that the end face of the sealing cover corresponds to detent seat offers through-hole, and is fixedly installed seal rubber plug by through-hole, institute The end face for stating sealing cover is inlaid with the display screen for touching structure, and the input terminal of the display screen is electrically connected with processor, described The input terminal of processor is connected with input keyboard and data statistics module, and the centrifugation motor is fixedly mounted on the bottom of sampler chamber Portion, the input terminal of the centrifugation motor and the output end of processor are electrically connected, and the output end of the centrifugation motor passes through output The bottom of axis and rotating disc is fixedly mounted.

Preferably, the bottom end face that the bottom of the sampler chamber corresponds to rotating disc is provided with guiding axis, the rotating disc bottom End surface is fixedly mounted by guide holder and guiding axis.When being centrifuged motor operation by output shaft drive turn disc, turn Moving plate improves rotating disc and drives centrifuge tube rotation to centrifuge tube inside blood by guide holder guided rotation inside guiding axis Starch the stability of centrifugally operated.

Preferably, the sampler chamber and centrifuge tube are all made of transparent configuration setting, and the centrifuge tube is equal by card slot It is distributed in sampler chamber interior periphery.Experimenter takes out the blood inside centrifuge tube according to the blood after the centrifugation to different periods It takes, the centrifuge tube and sampler chamber of transparent configuration are convenient for experimenter according to analysis centrifugal test tube interior plasma layer extraction operation.

Preferably, the end face of the seal rubber plug is provided with time identifier plate.Different periods are taken out by time identifier plate It takes the time identifier of subject's venous blood, and when extracting blood to subject is directly output to the blood of extraction opposite Inside centrifuge tube corresponding to time identifier plate.

Preferably, the data statistics module is statistical table software, and the output end of the processor is electrically connected with number According to storage module, the input terminal of the data statistics module is electrically connected by the output end of data acquisition module and input keyboard It connects.Experimenter inputs the time taken blood and extraction amount according to the time extracted to subject's blood, by input keyboard, Data acquisition module acquires data and exports to data statistics module table corresponding with the time, and processor passes through data Storage module is input to the data storage of data acquisition module to input keyboard, convenient for the data after to medicine dynamics sampling analysis It compares so as to drug, the drug effect concentration data of different periods is checked in subject's body.

Compared with prior art, beneficial effects of the present invention are as follows:

1, the present invention installs centrifuge tube by rotating disc inside sampler chamber, and setting passes through processor at the top of sealing cover It is connected with the display screen of data acquisition module, by the end fixing card master of centrifuge tube on the card slot of rotation side surface, sealing Lid seals the top of centrifuge tube by the detent seat of rotating plate internal end surface and clamps, and is adopted to subject according to different periods When collecting blood, after being extracted by the syringe that extraction blood uses to subject's venous blood, and worn by the syringe needle that syringe extracts It crosses inside seal rubber plug and centrifuge tube and communicates, the blood taken is directly output to the centrifugation of corresponding different periods by syringe Test tube interior, centrifugation motor connection city's electricity operation drive turn disc by output shaft, and rotating disc drives centrifuge tube rotation To centrifuge tube inside blood plasma centrifugally operated, the rotating plate at sealing cover center is by rotating disc as centrifuge tube is with auxiliary Help rotating disc to blood rotation centrifugation in centrifuge tube, when to blood analysis after centrifugation, experimenter is by extracting needle tubing to needing Blood plasma inside the centrifuge tube to be analyzed extracts analysis, and experimenter passes through input according to the time extracted to subject's blood The time and extraction amount that blood is taken in keyboard input, data acquisition module data acquires and export to data statistics module and Inside time corresponding table, processor is stored up by the data that data storage module is input to data acquisition module to input keyboard Deposit, convenient for after to medicine dynamics sampling analysis data compare it is dense with the drug effect to drug different periods in subject's body Degree is it is investigated that see.

2, the present invention seal rubber plug end face be arranged time identifier plate, by time identifier plate to different periods extract by The time identifier of examination person's venous blood, and the blood of extraction is directly output to the opposite time when extracting blood to subject Inside centrifuge tube corresponding to marking plate.

Detailed description of the invention

Fig. 1 is overall structure of the present invention；

Fig. 2 is Fig. 1 overlooking structure diagram of the present invention；

Fig. 3 is processor theory structure schematic diagram of the present invention.

In figure: 1 sampler chamber；11 rotating discs；12 guiding axis；122 guide holders；13 sealing covers；131 rotating plates；132 detents Seat；133 rotating discs；2 centrifugation motors；21 output shafts；22 processors；221 input keyboards；222 data statistics modules；223 data Acquisition module；23 data storage modules；3 centrifuge tubes；31 card slots；32 seal rubber plugs；321 through-holes；322 time identifier plates；33 Display screen.

Specific embodiment

Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.

Please refer to Fig. 1-3, a kind of pharmacokinetics sampling and data gathering system, including sampler chamber 1, centrifugation motor 2 and centrifuge tube 3, rotating disc 11 is fixedly installed with inside the sampler chamber 1, and the end face of the rotating disc 11 offers and is centrifuged The bottom of the corresponding card slot 31 in 3 bottom of test tube, the centrifuge tube 3 is clamped by the way that the end face of card slot 31 and rotating disc 11 is fixed, The bottom end face that the bottom of the sampler chamber 1 corresponds to rotating disc 11 is provided with guiding axis 12, and 11 bottom end face of rotating disc is logical It crosses guide holder 121 and guiding axis 12 is fixedly mounted.When being centrifuged the operation of motor 2 by the drive rotation of rotating disc 11 of output shaft 21, Rotating disc 11 by guide holder 121 in 12 inside guided rotation of guiding axis, improve rotating disc 11 drive the rotation of centrifuge tube 3 to from The stability of 3 inside blood plasma centrifugally operated of heart test tube.The sampler chamber 1 and centrifuge tube 3 are all made of transparent configuration setting, described Centrifuge tube 3 is distributed in 1 interior periphery of sampler chamber by card slot 31.Experimenter is according to the blood after the centrifugation to different periods Blood inside centrifuge tube 3 is extracted, the centrifuge tube 3 and sampler chamber 1 of transparent configuration are convenient for experimenter according to analysis centrifugal 3 inside plasma layer extraction operation of test tube.The top of the sampler chamber 1 is fixedly installed with sealing cover 13, inside the sealing cover 13 The top that end face corresponds to centrifuge tube 3 is fixedly installed detent seat 132, the week of the rotating plate 131 by rotating plate 131 Side is fixedly mounted by rotating disc 133 and sealing cover 13, and the center that the end face of the sealing cover 13 corresponds to detent seat 132 offers Through-hole 321, and seal rubber plug 32 is fixedly installed by through-hole 321, the end face of the seal rubber plug 32 is provided with time identifier Plate 322.By time identifier plate 322 different periods are extracted with the time identifier of subject's venous blood, and is taken out to subject It takes and the blood of extraction is directly output to inside centrifuge tube 3 corresponding to opposite time identifier plate 322 when blood.It is described close The end face of capping 13 is inlaid with the display screen 33 for touching structure, and the input terminal of the display screen 33 is electrically connected with processor 22, The input terminal of the processor 22 is connected with input keyboard 221 and data statistics module 222, and the centrifugation motor 2 is fixedly mounted In the bottom of sampler chamber 1, the input terminal of the centrifugation motor 2 and the output end of processor 22 are electrically connected, the centrifugation motor 2 Output end be fixedly mounted by the bottom of output shaft 21 and rotating disc 11.The data statistics module 222 is that statistical table is soft Part, the output end of the processor 22 are electrically connected with data storage module 23, and the input terminal of the data statistics module 222 is logical The output end for crossing data acquisition module 223 and input keyboard 221 is electrically connected.Experimenter according to subject's blood extract when Between, the time taken by the input of input keyboard 221 to blood and extraction amount, data acquisition module 223 acquire data and defeated Out to inside the table corresponding with the time of data statistics module 222, processor 22 is by data storage module 23 to input keyboard 221 are input to the data storage of data acquisition module 223, convenient for after to medicine dynamics sampling analysis data compare with right Drug drug effect concentration data of different periods in subject's body is checked.

In use, the different periods is identified by 322 pairs of time identifier plate different centrifuge tubes 3, by centrifuge tube 3 End fixing card master on the card slot 31 of 11 end face of rotating disc, sealing cover 13 passes through the detent of 131 internal end surface of rotating plate The top of 132 pairs of centrifuge tubes 3 of seat, which seals, to be clamped, and when acquiring blood according to different periods to subject, is made by extracting blood After syringe extracts subject's venous blood, and seal rubber plug 32 and centrifuge tube 3 are passed through by the syringe needle that syringe extracts Inside communicates, and the blood taken is directly output to inside the centrifuge tube 3 of corresponding different periods by syringe, is centrifuged motor 2 It connects city's electricity operation and drives rotating disc 11 to rotate by output shaft 21, rotating disc 11 drives the rotation of centrifuge tube 3 to centrifuge tube 3 Internal blood plasma centrifugally operated, the rotating plate 131 at 13 center of sealing cover is by rotating disc 133 as centrifuge tube 3 is with auxiliary Help rotating disc 11 to blood rotation centrifugation in centrifuge tube 3, when to blood analysis after centrifugation, experimenter is by extracting needle tubing pair Blood plasma inside the centrifuge tube 3 for needing to analyze extracts analysis, and experimenter is according to the time extracted to subject's blood, by defeated Enter keyboard 221 and input the time taken blood and extraction amount, data acquisition module 223 acquires data and exports to data and unites It counts inside the table corresponding with the time of module 222, processor 22 is input to number to input keyboard 221 by data storage module 23 According to the data storage of acquisition module 223, convenient for after to medicine dynamics sampling analysis data compare with to drug tested The drug effect concentration data of different periods is checked in person's body.

In summary: a kind of pharmacokinetics sampling and data gathering system pass through rotation inside sampler chamber 1 Disk 11 installs centrifuge tube 3, and is connected with the aobvious of data statistics module 222 by processor 22 in the setting of the top of sealing cover 13 Display screen 33, by the end fixing card master of centrifuge tube 3 on the card slot 31 of 11 end face of rotating disc, sealing cover 13 passes through rotating plate The top of 132 pairs of centrifuge tubes 3 of detent seat of 131 internal end surfaces, which seals, to be clamped, and acquires blood according to different periods to subject When, after extracting by the syringe that extraction blood uses to subject's venous blood, and sealing is passed through by the syringe needle that syringe extracts It communicates inside rubber plug 32 and centrifuge tube 3, is tried the centrifugation that the blood taken is directly output to corresponding different periods by syringe Inside pipe 3, centrifugation motor 2 connects city's electricity operation and drives rotating disc 11 to rotate by output shaft 21, and rotating disc 11 drives centrifugation examination The rotation of pipe 3 to 3 inside blood plasma centrifugally operated of centrifuge tube, the rotating plate 131 at 13 center of sealing cover by rotating disc 133 with Centrifuge tube 3 with auxiliary rotating disc 11 to blood rotation centrifugation in centrifuge tube 3, it is real when to blood analysis after centrifugation The person of testing extracts analysis by extracting the blood plasma inside the centrifuge tube 3 that needle tubing analyzes needs, and experimenter is according to subject's blood The time that liquid extracts inputs the time taken blood and extraction amount, 223 logarithm of data acquisition module by input keyboard 221 According to acquiring and exporting to the table corresponding with the time of data statistics module 222, processor 22 passes through data storage module 23 The data storage of data acquisition module 223 is input to input keyboard 221, it is right after the existing dynamics sampled plasma to medicine to solve Transfer is needed when blood plasma centrifugally operated, increases the probability of bacterium in blood plasma infection air, and sampled plasma data are indicated It is more inconvenient, easily to the data obfuscation of acquisition blood plasma the problem of.

It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.