阅读说明：本技术 一种多通道冷冻消融系统及控制方法 (Multi-channel cryoablation system and control method ) 是由 喻为秋 徐彬凯 于 2021-08-12 设计创作，主要内容包括：本发明公开了一种多通道冷冻消融系统,使用高压氮气作为气源,该系统包括气体主管路、复温管路、冷冻高压管路、冷冻低压管路,所述气体主管路上设有气源输入口,所述复温管路连通所述气体主管路,所述复温管路分为N路复温分支通道；所述冷冻高压管路连通所述气体主管路,所述冷冻低压管路连通所述气体主管路,并且,所述冷冻低压管路与所述与冷冻高压管路后段共同一段供气通路,该供气通路连通至N路冷冻分支通道；N路通道管路,每路通道管路的一端用于连接一消融针,另一端用于连接一路冷冻分支通道和/或一路复温分支通道；其中,N为大于等于2的正整数。(The invention discloses a multi-channel cryoablation system, which uses high-pressure nitrogen as a gas source and comprises a gas main pipeline, a rewarming pipeline, a freezing high-pressure pipeline and a freezing low-pressure pipeline, wherein the gas main pipeline is provided with a gas source input port, the rewarming pipeline is communicated with the gas main pipeline, and the rewarming pipeline is divided into N rewarming branch channels; the freezing high-pressure pipeline is communicated with the gas main pipeline, the freezing low-pressure pipeline and the rear section of the freezing high-pressure pipeline share one gas supply passage, and the gas supply passage is communicated to N freezing branch channels; one end of each channel pipeline is connected with an ablation needle, and the other end of each channel pipeline is connected with a freezing branch channel and/or a rewarming branch channel; wherein N is a positive integer greater than or equal to 2.)

1. A multi-channel cryoablation system using high pressure nitrogen as a gas source, comprising:

the gas main pipeline is provided with a gas source input port, a first pressure measuring device and a gas main valve, wherein the gas source input port is used for being connected with a high-pressure nitrogen gas source, the first pressure measuring device is used for obtaining the gas pressure of the high-pressure nitrogen gas bottle, and the gas main valve can realize the connection/disconnection of high-pressure nitrogen gas in the main pipeline;

the rewarming pipeline is communicated with the gas main pipeline; the rewarming pipeline is provided with a first gas output pressure regulating device, a second pressure measuring device and a rewarming pipeline main valve, the first gas output pressure regulating device can regulate the gas output pressure of the rewarming pipeline, the second pressure measuring device is used for acquiring the output pressure of the first gas output pressure regulating device, and the rewarming pipeline main valve can realize the on/off of high-pressure nitrogen in the rewarming pipeline; the rewarming pipeline is divided into N rewarming branch channels behind the rewarming pipeline main valve, and each rewarming branch channel is provided with a branch channel valve for realizing on/off of a gas channel;

the freezing high-pressure pipeline and the freezing low-pressure pipeline are respectively communicated with the gas main pipeline; the system comprises a freezing high-pressure pipeline, a freezing high-pressure pipeline main valve, a first gas output pressure regulating device, a second gas output pressure measuring device and a freezing high-pressure pipeline main valve, wherein the freezing high-pressure pipeline is provided with the second gas output pressure regulating device, the third pressure measuring device and the freezing high-pressure pipeline main valve; the freezing low-pressure pipeline is provided with a third gas output pressure regulating device, a fourth pressure measuring device and a freezing low-pressure pipeline main valve, the third gas output pressure regulating device can regulate the gas output pressure of the freezing low-pressure pipeline, the fourth pressure measuring device is used for acquiring the output pressure of the third gas output pressure regulating device, and the freezing low-pressure pipeline main valve can realize the on/off of high-pressure nitrogen in the freezing low-pressure pipeline; the part of the freezing low-pressure pipeline behind the freezing low-pressure pipeline main valve and the part of the freezing high-pressure pipeline behind the freezing high-pressure pipeline main valve share a section of gas passage, the gas passage is communicated to N freezing branch channels, and each freezing branch channel is provided with a branch channel valve for realizing gas passage on/off;

one end of each channel pipeline is connected with an ablation needle, and the other end of each channel pipeline is connected with a freezing branch channel and/or a rewarming branch channel; each channel pipeline is also provided with a fifth pressure measuring device, a pipeline exhaust hole and a valve for controlling the pipeline exhaust hole to open and close; each ablation needle is connected with an air outlet or is provided with an air outlet;

wherein N is a positive integer greater than or equal to 2.

2. The multi-channel cryoablation system of claim 1 wherein N is a positive integer greater than or equal to 3.

3. The multi-channel cryoablation system of claim 1, wherein the gas main valve, the rewarming line main valve, the freezing high-pressure line main valve and the freezing low-pressure line main valve are solenoid valves, the branch channel valve is a solenoid valve, and the valve for controlling the opening and closing of the pipeline exhaust hole is a solenoid valve.

4. A multi-channel cryoablation system according to claim 1 wherein said first/second/third gas output pressure regulating device is a pressure relief valve.

5. The multi-channel cryoablation system of claim 3, wherein said ablation needle further comprises an electrical interface comprising a temperature measuring device wire, a re-temperature thermal resistance wire, and an identification interface wire; the multichannel cryoablation system further comprises a control module, the control module comprises a pressure measurement module, a temperature measurement module, a switch module, an ablation needle locking module and an ablation needle identification module, wherein the control module is used for acquiring data of all pressure measurement devices through the pressure measurement module, acquiring all temperatures of the ablation needle through the temperature measurement module, controlling the electromagnetic valve and the switch of the rewarming power supply of the ablation needle through the switch module, locking the ablation needle with the gas interface of the channel pipeline through the ablation needle identification module, and identifying the ablation needle.

6. A multi-channel cryoablation control method implementable within the multi-channel cryoablation system of any of claims 1-5, the method comprising:

preparing an ablation needle: marking each ablation needle as prepared or not in a control module, wherein the marking that the ablation needle is prepared needs to meet the requirements that an ablation needle locking interface is locked, the temperature of the ablation needle can be acquired, a rewarming power supply is available and an ablation needle identification interface is available, and if any one of the conditions is not met, marking the corresponding ablation needle as not prepared;

selecting a freezing high-pressure pipeline and a freezing low-pressure pipeline: in the control module, the freezing high-pressure pipeline or the freezing low-pressure pipeline is determined to be selected according to the number of ablation needles prepared in the ablation needle preparation stage; when more than three ablation needles are used, a freezing high-pressure pipeline is selected, and when less than three ablation needles are used, a freezing low-pressure pipeline is selected;

use of an ablation needle: freezing, ablating and rewarming the selected one or more ablation needles; when the on-off of the gas circuit is controlled at a certain stage of the freezing, melting and rewarming processes of each ablation needle, the gas main valve, the rewarming pipeline main valve, the freezing high-pressure pipeline main valve and the freezing low-pressure pipeline main valve need to be opened and closed according to the requirements of the gas circuit on the stage of treatment of the other ablation needles using the same pipeline.

7. The multi-channel cryoablation control method of claim 6 further comprising the following venting method: before the unlocking operation of the ablation needle gas interface is carried out, air is exhausted.

8. The multi-channel cryoablation control method of claim 6 further comprising the following venting method: after the freezing function or the rewarming function of the ablation needle is completed, an air exhausting operation is performed.

9. The multi-channel cryoablation control method of claim 6 further comprising: when the first pressure measuring device detects that the pressure value of the gas cylinder is lower than the preset lower limit pressure value, a prompt signal is sent.

10. The multi-channel cryoablation control method of claim 6 wherein the output pressure of the first/second/third gas output pressure adjusting device is manually adjusted, and after the adjustment of the first/second/third gas output pressure adjusting device is completed, the control module determines whether the output pressure of the first/second/third gas output pressure adjusting device is within a predetermined range based on the pressure value, and further determines a failure condition of the first/second/third gas output pressure adjusting device.

11. The multi-channel cryoablation control method of claim 6 further comprising: and the control module judges whether the gas reaches the position according to the pressure value measured by the fifth pressure measuring device on each channel of pipeline.

12. The multi-channel cryoablation control method of claim 6 further comprising: when the exhaust function of the ablation needle is executed, if the control module receives the information that the pressure value measured by the fifth pressure measuring device on the channel pipeline is close to 0, the control module judges that the gas in the exhaust pipeline on the channel pipeline is exhausted.

13. A multi-channel cryoablation system using high pressure nitrogen as a gas source, comprising:

the gas main pipeline is provided with a gas source input port, and the gas source input port is used for being connected with a high-pressure nitrogen gas source; the gas main pipeline is respectively connected and communicated with at least one rewarming pipeline and at least one freezing pipeline; wherein the content of the first and second substances,

each rewarming pipeline is provided with a first gas output pressure regulating device, and the first gas output pressure regulating device can regulate the gas output pressure of the corresponding rewarming pipeline; each rewarming pipeline is divided into N rewarming branch channels after the first gas output pressure regulating device, each rewarming branch channel is provided with a branch channel valve, and the branch channel valve can realize the on-off of high-pressure nitrogen in the rewarming branch channel;

each freezing pipeline is provided with a second gas output pressure adjusting device, and the second gas output pressure adjusting device can adjust the gas output pressure of the freezing pipeline; each freezing pipeline is divided into N freezing branch channels after the second gas output pressure regulating device, each freezing branch channel is provided with a branch channel valve, and the branch channel valve can realize the on-off of high-pressure nitrogen in the freezing branch channel;

one end of each channel pipeline is connected with an ablation needle, and the other end of each channel pipeline is connected with a freezing branch channel and/or a rewarming branch channel;

wherein N is a positive integer greater than or equal to 2.

14. The multi-channel cryoablation system of claim 13 comprising more than two cryolines, wherein the pressure in each cryoline is different from the pressure in each cryoline.

15. A multi-channel cryoablation system according to claim 14 wherein more than two cryolines are configured in a multiplexed configuration, at least two of the cryolines sharing a common line segment after their respective second gas output pressure regulating devices, the common line segment being connectable to each of the cryobranch channels.

16. The multi-channel cryoablation system of claim 13, wherein each of the rewarming lines has a rewarming line main valve, the rewarming line main valve enabling the high pressure nitrogen in the rewarming line to be turned on and off; and each freezing pipeline is provided with a freezing pipeline main valve, and the freezing pipeline main valve can realize the on-off of high-pressure nitrogen in the freezing pipeline.

17. A multi-channel cryoablation system according to claim 13 or 16, wherein a main gas line is provided with a main gas valve, and the main gas line can be opened and closed by high-pressure nitrogen gas in the main gas line.

18. A multi-channel cryoablation system according to claim 13, further comprising said first pressure measuring device on said gas main for measuring the gas pressure of said high pressure nitrogen gas cylinder.

19. A multi-channel cryoablation system according to claim 13 or 18 wherein each of said rewarming conduits is provided with a second pressure measuring device for obtaining the output pressure of said first gas output pressure regulating device; and each freezing pipeline is provided with a third pressure measuring device, and the third pressure measuring device is used for acquiring the output pressure of the second gas output pressure regulating device.

20. A multi-channel cryoablation system according to claim 13 wherein a pressure measuring device is further provided in each of said channel lines.

21. A multi-channel cryoablation system according to claim 13 wherein each of said plurality of channels is further provided with a channel vent and a valve for controlling the opening and closing of said channel vent; each ablation needle is connected with an air outlet or is provided with an air outlet.

22. A multi-channel cryoablation system according to claim 18 or 19 wherein all valves used in the circuit that perform the on-off function are solenoid valves.

23. A multi-channel cryoablation system according to claim 13 wherein said first/second gas output pressure regulating device is a pressure relief valve.

24. The multi-channel cryoablation system of claim 22 wherein said ablation needle is provided with an electrical interface comprising a temperature measuring device wire, a re-temperature thermal resistance wire, an identification interface wire; the multichannel cryoablation system further comprises a control module, the control module comprises a pressure measurement module, a temperature measurement module, a switch module, an ablation needle locking module and an ablation needle identification module, wherein the control module is used for acquiring data of all pressure measurement devices through the pressure measurement module, acquiring all temperatures of the ablation needle through the temperature measurement module, controlling the electromagnetic valve and the switch of the rewarming power supply of the ablation needle through the switch module, locking the ablation needle with the gas interface of the channel pipeline through the ablation needle identification module, and identifying the ablation needle.

Technical Field

The invention relates to a multi-channel cryoablation system using high-pressure nitrogen as a gas source and a multi-channel cryoablation control method implemented on the system.

Background

The cryoablation is used as a minimally invasive targeted operation, has the characteristics of small wound, small toxic and side effect and definite curative effect, and also has the advantages of clear ablation ice ball boundary, capability of participating in activating the tumor immune function of an organism, no damage to large blood vessels, no obvious pain and the like, so that the ultralow-temperature targeted freezing and thermal therapy of tumors become reality. In recent years, cryosurgery has been widely used for the treatment of metastatic liver cancer, prostate cancer, kidney cancer, and the like.

The multi-channel cryoablation system has the function of combining a plurality of ablation needles. Because the freezing area formed by a single ablation needle on the tumor tissue of a human body is limited, when the tumor tissue is large in size, the freezing area can be enlarged by jointly using a plurality of ablation needles, and the large tumor tissue can be effectively covered. The cryoablation system is designed to be provided with a plurality of channels, can be connected with a plurality of ablation needles, and can ablate tumor tissues with different volumes through the combination of the number of the ablation needles, so that the applicability of the device is stronger.

The mainstream multichannel cryoablation systems in the market at present have the following two types:

argon-helium cryogenic systems, related patent documents such as CN208756146U, which discloses a cryosurgical system using 3000psi argon as the source of cryogenic gas;

liquid nitrogen cryoablation systems, related patent documents such as CN210582629U, disclose a cryoablation system that uses cryogenic liquid nitrogen as the freezing source.

A multi-channel cryoablation device or system using high pressure nitrogen as a gas source has not been developed.

Disclosure of Invention

The invention provides a multi-channel cryoablation system and a control method, which are suitable for using high-pressure nitrogen as a gas source.

The technical scheme of the invention is as follows:

a multi-channel cryoablation system using high pressure nitrogen as a gas source, comprising:

the gas main pipeline is provided with a gas source input port, a first pressure measuring device and a gas main valve, wherein the gas source input port is used for being connected with a high-pressure nitrogen gas source, the first pressure measuring device is used for obtaining the gas pressure of the high-pressure nitrogen gas bottle, and the gas main valve can realize the connection/disconnection of high-pressure nitrogen gas in the main pipeline;

the rewarming pipeline is communicated with the gas main pipeline; the rewarming pipeline is provided with a first gas output pressure regulating device, a second pressure measuring device and a rewarming pipeline main valve, the first gas output pressure regulating device can regulate the gas output pressure of the rewarming pipeline, the second pressure measuring device is used for acquiring the output pressure of the first gas output pressure regulating device, and the rewarming pipeline main valve can realize the on/off of high-pressure nitrogen in the rewarming pipeline; the rewarming pipeline is divided into N rewarming branch channels behind the rewarming pipeline main valve, and each rewarming branch channel is provided with a branch channel valve for realizing on/off of a gas channel;

the freezing high-pressure pipeline and the freezing low-pressure pipeline are respectively communicated with the gas main pipeline; the system comprises a freezing high-pressure pipeline, a freezing high-pressure pipeline main valve, a first gas output pressure regulating device, a second gas output pressure measuring device and a freezing high-pressure pipeline main valve, wherein the freezing high-pressure pipeline is provided with the second gas output pressure regulating device, the third pressure measuring device and the freezing high-pressure pipeline main valve; the freezing low-pressure pipeline is provided with a third gas output pressure regulating device, a fourth pressure measuring device and a freezing low-pressure pipeline main valve, the third gas output pressure regulating device can regulate the gas output pressure of the freezing low-pressure pipeline, the fourth pressure measuring device is used for acquiring the output pressure of the third gas output pressure regulating device, and the freezing low-pressure pipeline main valve can realize the on/off of high-pressure nitrogen in the freezing low-pressure pipeline; the part of the freezing low-pressure pipeline behind the freezing low-pressure pipeline main valve and the part of the freezing high-pressure pipeline behind the freezing high-pressure pipeline main valve share a section of gas passage, the gas passage is communicated to N freezing branch channels, and each freezing branch channel is provided with a branch channel valve for realizing gas passage on/off;

one end of each channel pipeline is connected with an ablation needle, and the other end of each channel pipeline is connected with a freezing branch channel and/or a rewarming branch channel; each channel pipeline is also provided with a fifth pressure measuring device, a pipeline exhaust hole and a valve for controlling the pipeline exhaust hole to open and close; each ablation needle is connected with an air outlet or is provided with an air outlet;

wherein N is a positive integer greater than or equal to 2. When N is a positive integer equal to 2, the multi-channel cryoablation system is a two-channel cryoablation system. And so on.

In a preferred embodiment, N is a positive integer of 3 or more. When N is a positive integer equal to 3, the multi-channel cryoablation system is a three-channel cryoablation system. And so on.

In a preferred embodiment, the gas main valve, the rewarming line main valve, the freezing high-pressure line main valve and the freezing low-pressure line main valve are solenoid valves, the branch channel valve is a solenoid valve, and the valve for controlling the opening and closing of the pipeline exhaust hole is a solenoid valve. The selection of the electromagnetic valve facilitates automatic control through the control module.

In a preferred embodiment, the first/second/third gas output pressure regulating device is a pressure reducing valve. The pressure reducing valve can be a manually adjusted pressure reducing valve or a pressure reducing valve automatically controlled by a control module.

In a preferred embodiment, the ablation needle is further provided with an electrical interface, and the electrical interface comprises a temperature measuring device wire, a rewarming thermal resistance wire and an identification interface wire; the multichannel cryoablation system further comprises a control module, the control module comprises a pressure measurement module, a temperature measurement module, a switch module, an ablation needle locking module and an ablation needle identification module, wherein the control module is used for acquiring data of all pressure measurement devices through the pressure measurement module, acquiring all temperatures of the ablation needle through the temperature measurement module, controlling the electromagnetic valve and the switch of the rewarming power supply of the ablation needle through the switch module, locking the ablation needle with the gas interface of the channel pipeline through the ablation needle identification module, and identifying the ablation needle. The multi-channel cryoablation system is high in automation degree due to the arrangement.

Based on the same inventive concept, the present invention also provides a multi-channel cryoablation control method, which can be implemented in any one of the above multi-channel cryoablation systems, and the method comprises:

preparing an ablation needle: marking each ablation needle as prepared or not in a control module, wherein the marking that the ablation needle is prepared needs to meet the requirements that an ablation needle locking interface is locked, the temperature of the ablation needle can be acquired, a rewarming power supply is available and an ablation needle identification interface is available, and if any one of the conditions is not met, marking the corresponding ablation needle as not prepared;

selecting a freezing high-pressure pipeline and a freezing low-pressure pipeline: in the control module, the freezing high-pressure pipeline or the freezing low-pressure pipeline is determined to be selected according to the number of ablation needles prepared in the ablation needle preparation stage; when more than three ablation needles are used, a freezing high-pressure pipeline is selected, and when less than three ablation needles are used, a freezing low-pressure pipeline is selected;

use of an ablation needle: freezing, ablating and rewarming the selected one or more ablation needles; when the on-off of the gas circuit is controlled at a certain stage of the freezing, melting and rewarming processes of each ablation needle, the gas main valve, the rewarming pipeline main valve, the freezing high-pressure pipeline main valve and the freezing low-pressure pipeline main valve need to be opened and closed according to the requirements of the gas circuit on the stage of treatment of the other ablation needles using the same pipeline.

In a preferred embodiment, the control method further includes an exhaust method of: before the unlocking operation of the ablation needle gas interface is carried out, air is exhausted.

In a preferred embodiment, the control method further includes an exhaust method of: after the freezing function or the rewarming function of the ablation needle is completed, an air exhausting operation is performed.

In a preferred embodiment, the control method further includes: when the first pressure measuring device detects that the pressure value of the gas cylinder is lower than the preset lower limit pressure value, a prompt signal is sent.

In a preferred embodiment, the output pressure of the first/second/third gas output pressure regulating device is manually regulated, and after the regulation of the first/second/third gas output pressure regulating device is completed, the control module determines whether the output pressure of the first/second/third gas output pressure regulating device is within a predetermined range according to the pressure value, and further determines the fault condition of the first/second/third gas output pressure regulating device.

In a preferred embodiment, the control method further includes: and the control module judges whether the gas reaches the position according to the pressure value measured by the fifth pressure measuring device on each channel of pipeline.

In a preferred embodiment, the control method further includes: when the exhaust function of the ablation needle is executed, if the control module receives the information that the pressure value measured by the fifth pressure measuring device on the channel pipeline is close to 0, the control module judges that the gas in the exhaust pipeline on the channel pipeline is exhausted.

Based on the same inventive concept, the present invention also provides a multi-channel cryoablation system using high-pressure nitrogen as a gas source, comprising:

the gas main pipeline is provided with a gas source input port, and the gas source input port is used for being connected with a high-pressure nitrogen gas source; the gas main pipeline is respectively connected and communicated with at least one rewarming pipeline and at least one freezing pipeline; wherein the content of the first and second substances,

each rewarming pipeline is provided with a first gas output pressure regulating device, and the first gas output pressure regulating device can regulate the gas output pressure of the corresponding rewarming pipeline; each rewarming pipeline is divided into N rewarming branch channels after the first gas output pressure regulating device, each rewarming branch channel is provided with a branch channel valve, and the branch channel valve can realize the on-off of high-pressure nitrogen in the rewarming branch channel;

each freezing pipeline is provided with a second gas output pressure adjusting device, and the second gas output pressure adjusting device can adjust the gas output pressure of the freezing pipeline; each freezing pipeline is divided into N freezing branch channels after the second gas output pressure regulating device, each freezing branch channel is provided with a branch channel valve, and the branch channel valve can realize the on-off of high-pressure nitrogen in the freezing branch channel;

one end of each channel pipeline is connected with an ablation needle, and the other end of each channel pipeline is connected with a freezing branch channel and/or a rewarming branch channel;

wherein N is a positive integer greater than or equal to 2.

For the above-described multi-channel cryoablation system of the present invention, the number of cryolines may be one, two, three, or more. Whether one or multiple freezing pipelines are adopted is determined according to the number of designed channels and the number of actually used channels of the system, for example, if the multi-channel cryoablation system is provided with three channels, high-pressure/low-pressure pipelines need to be distinguished, if the multi-channel cryoablation system is only provided with two channels, the pipelines only have low-pressure pipelines and do not have high-pressure pipelines; if three channels are designed, only two of the three channels are used in actual use, and only a low-pressure pipeline is used; and when three channels are actually used, a high-pressure pipeline is needed. If the passages are sufficiently large, e.g., more than three passages, then a chilled high/medium/low pressure line may be provided.

In a preferred embodiment, the multi-channel cryoablation system comprises more than two cryolines, wherein the pressure in each cryoline is different from the pressure in the other cryolines. In the two-way freezing pipeline structure, the gas pressure values in the freezing pipelines are different, and the two-way freezing pipeline structure can be called as a freezing high-pressure pipeline and a freezing low-pressure pipeline; in the three-way freezing pipeline structure, the gas pressure values in the freezing pipelines are different, and the three-way freezing pipeline structure can be called as a freezing high-pressure pipeline, a freezing medium-pressure pipeline and a freezing low-pressure pipeline.

For a multi-channel cryoablation system with more than two freezing pipelines, each freezing pipeline may be provided with a freezing branch channel, but more preferably, the more than two freezing pipelines may be designed as a multiplexing structure, at least two freezing pipelines share a pipeline section behind the respective second gas output pressure regulating device, and the shared pipeline section can be communicated to each freezing branch channel. The refrigerating pipeline above the refrigerating fluid is designed into a multiplex structure, so that the number of refrigerating branch channels can be greatly saved, and the cost and the equipment installation complexity are reduced.

In a preferred embodiment, each rewarming pipeline is provided with a rewarming pipeline main valve, and the rewarming pipeline main valve can realize the on-off of high-pressure nitrogen in the rewarming pipeline; and each freezing pipeline is provided with a freezing pipeline main valve, and the freezing pipeline main valve can realize the on-off of high-pressure nitrogen in the freezing pipeline. The arrangement of the main valve on each pipeline can ensure that the air path control on each pipeline is more reliable.

In a preferred embodiment, a gas main valve is arranged on the gas main pipeline, and the gas main valve can realize the on-off of high-pressure nitrogen in the main pipeline. The gas circuit control on the gas main pipeline can be more reliable due to the arrangement of the gas main valve.

In a preferred embodiment, the system further comprises the first pressure measuring device arranged on the gas main pipeline, and the first pressure measuring device is used for measuring the gas pressure of the high-pressure nitrogen gas cylinder. And a first pressure measuring device is arranged, and whether the air source is available or not can be judged according to the pressure measuring result and a preset lower limit value.

In a preferred embodiment, each of the reheating pipelines is provided with a second pressure measuring device, and the second pressure measuring device is used for acquiring the output pressure of the first gas output pressure regulating device; and each freezing pipeline is provided with a third pressure measuring device, and the third pressure measuring device is used for acquiring the output pressure of the second gas output pressure regulating device. By arranging the pressure measuring devices, whether the output pressure of the corresponding pressure reducing valve is in a preset range or not can be judged according to the measured pressure values, and whether the pressure reducing valve has a fault or not can be further judged.

In a preferred embodiment, each of the passage pipes is further provided with a pressure measuring device. Thus, the following steps are realized: when the freezing and rewarming functions of the ablation needle are executed, the pressure value measured by the pressure measuring device can judge whether the gas on the corresponding channel pipeline reaches the position, and if the pipeline between the channel pipeline and the gas source is blocked, the gas may not reach the position. In addition, when the exhaust function is executed, when the pressure value measured by the pressure measuring device is close to 0, the exhaust pipeline is known to be exhausted.

The above pressure measuring device may be a pressure sensor.

In a preferred embodiment, each channel pipeline is further provided with a pipeline exhaust hole and a valve for controlling the opening and closing of the pipeline exhaust hole; each ablation needle is connected with an air outlet or is provided with an air outlet. Such an arrangement enables venting of the channel lines and the ablation needle.

In a preferred embodiment, all valves used in the circuit that perform the on-off function are solenoid valves. The selection of the electromagnetic valve facilitates automatic control through the control module.

In a preferred embodiment, the first/second gas output pressure regulating device is a pressure reducing valve. The pressure reducing valve can be a manually adjusted pressure reducing valve or a pressure reducing valve automatically controlled by a control module.

In a preferred embodiment, an electrical interface is arranged on the ablation needle, and comprises a temperature measuring device wire, a re-temperature thermal resistance wire and an identification interface wire; the multichannel cryoablation system further comprises a control module, the control module comprises a pressure measurement module, a temperature measurement module, a switch module, an ablation needle locking module and an ablation needle identification module, wherein the control module is used for acquiring data of all pressure measurement devices through the pressure measurement module, acquiring all temperatures of the ablation needle through the temperature measurement module, controlling the electromagnetic valve and the switch of the rewarming power supply of the ablation needle through the switch module, locking the ablation needle with the gas interface of the channel pipeline through the ablation needle identification module, and identifying the ablation needle.

In the above, the symbol "/" represents "and/or", "and", or ".

Compared with the prior art, the invention has the following beneficial effects:

the invention provides a multi-channel cryoablation system using high-pressure nitrogen as an air source and a control method thereof for the first time, so that the high-pressure nitrogen can be used in the multi-channel system, and the advantages of high refrigeration capacity of the high-pressure nitrogen, low price and easiness in taking of the air source and the like can be utilized.

Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.

Drawings

FIG. 1 is a schematic view of an air circuit of a multi-channel cryoablation system in accordance with an embodiment of the present invention;

FIG. 2 is a schematic view of the channel tubing and ablation needle electrical interface of the multi-channel cryoablation system of an embodiment of the present invention;

FIG. 3 is a hardware block diagram of a control module of the multi-channel cryoablation system in accordance with an embodiment of the present invention;

FIG. 4 is a flow chart of the preparation of an ablation needle in the multi-channel cryoablation control method according to the embodiment of the present invention;

fig. 5 is a reference view of the use of the ablation needle 41 in the multi-channel cryoablation control method according to the embodiment of the present invention;

fig. 6 is a flowchart illustrating the control of the solenoid valve in the multi-channel cryoablation control method according to the embodiment of the invention.

Detailed Description

Although a multi-channel cryoablation system using argon or cryogenic liquid nitrogen as a cold source exists in the prior art, the change of the cold source can cause the change of the consideration factors of the design of the whole device or system, so that when the multi-channel cryoablation device or system using high-pressure nitrogen as a gas source is designed, the existing multi-channel cryoablation system using argon or cryogenic liquid nitrogen as the cold source cannot be simply and directly used for reference, and an overall design theory needs to be established again according to the use characteristics of the high-pressure nitrogen for design and development of the technical scheme.

The multi-channel cryoablation system provided by the invention is a low-temperature cryotherapy system which uses high-pressure nitrogen as an air source and is precooled by a host machine and then throttled by a cutter head, the refrigerating capacity is high, and the air source is cheaper and easier to obtain. In the multi-channel cryoablation system, high-pressure nitrogen is used as a gas source, so that the use problem of the nitrogen gas source when the required gas source available pressure ranges are different when a plurality of channels and a few channels are used for completing an operation is solved; the problems that when a plurality of ablation needle channels exist and each channel has the functions of freezing, rewarming, exhausting and the like, each channel has an exclusive device and also has a shared structure, the channels are isolated and exclusive access to single resources is achieved are solved; the problems that a plurality of channels exist, each channel can be inserted with an ablation needle, and the ablation needles of the channels are identified and the states of the ablation needles are judged are solved.

The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Examples

The gas pipeline of the multi-channel cryoablation system comprises a gas source input port for connecting a nitrogen gas cylinder, a plurality of pressure sensors, a plurality of electromagnetic valves, a plurality of pressure reducing valves, a plurality of pipeline exhaust holes, a plurality of ablation needle exhaust holes and a plurality of channel pipelines connected with ablation needles. In the following, referring to fig. 1, a three-channel cryoablation system is taken as an example to describe the gas pipeline, and on the premise that the three-channel cryoablation system is disclosed in the present invention, a person skilled in the art can easily obtain the specific structure of the cryoablation system with other number of channels, such as two channels, four channels, etc., and these modified embodiments are all within the protection scope of the present invention.

Referring to fig. 1, a gas pipeline of the multi-channel cryoablation system of the present embodiment is shown, in which a nitrogen gas cylinder 20 is connected to a gas main pipeline through a gas source input port, a pressure sensor 11 is used to obtain a gas pressure of the nitrogen gas cylinder 20, and an electromagnetic valve 21 is a gas main valve and can be controlled to switch on and off high-pressure nitrogen gas in the gas main pipeline.

The gas main pipeline is then communicated with a rewarming pipeline, a freezing high-pressure pipeline and a freezing low-pressure pipeline, wherein,

in the rewarming pipeline, the reducing valve 31 is used for controlling the gas output pressure in the rewarming pipeline, the pressure sensor 12 is used for obtaining the output pressure of the reducing valve 31, the electromagnetic valve 22 is a rewarming pipeline main valve and can realize the on-off of high-pressure nitrogen in the rewarming pipeline through control, the rewarming pipeline is divided into three rewarming branch passages behind the electromagnetic valve 22, and the electromagnetic valves 25, 26 and 27 are branch passage valves on the three rewarming branch passages of the rewarming pipeline respectively; in other embodiments, there are several channels, i.e. several branch channel valves are correspondingly arranged;

in the freezing high-pressure pipeline, the pressure reducing valve 32 is used for controlling the output pressure of the freezing high-pressure pipeline, the pressure sensor 13 is used for acquiring the output pressure of the pressure reducing valve 32, and the electromagnetic valve 23 is a main valve of the freezing high-pressure pipeline and can realize the on-off of high-pressure nitrogen in the freezing high-pressure pipeline through control;

in the freezing low-pressure pipeline, a pressure reducing valve 33 is used for controlling the output pressure of the freezing low-pressure pipeline, a pressure sensor 14 is used for acquiring the output pressure of the pressure reducing valve 33, and an electromagnetic valve 24 is a main valve of the freezing low-pressure pipeline and can realize the on-off of high-pressure nitrogen in the freezing low-pressure pipeline through control;

in fig. 1, the freezing high-pressure line and the freezing low-pressure line are multiplexed, that is, the freezing high-pressure line and the freezing low-pressure line share a section of line after the solenoid valves 23 and 24, the line can be communicated to the three-way freezing branch passage, and the solenoid valves 28, 29 and 210 respectively serve as branch passage valves on the three-way freezing branch passage.

The gas pipeline of the multi-channel cryoablation system shown in fig. 1 further includes three-way channel pipelines, i.e., three-way pipelines connected to the ablation needle, the three-way channel pipelines are identical in structural configuration, one end of each of the three-way channels is divided into two branches, one channel valve of the rewarming branch channel of the rewarming pipeline and one channel valve of the freezing branch channel of the freezing pipeline (the freezing high-pressure pipeline and the freezing low-pressure pipeline are multiplexed) are respectively connected to each of the three-way channel pipelines, each of the three-way channel pipelines is further connected to one channel exhaust solenoid valve and a pipeline exhaust hole, each of the three-way channel pipelines is further connected to a pressure sensor, the other end of each of the three-way channel pipelines is connected to the ablation needle, and the ablation needle is connected to or has an air outlet hole. Specifically, the left side of the first channel pipeline is connected with the electromagnetic valves 27 and 28, the right side of the first channel pipeline is connected with the ablation needle 41, the ablation needle 41 is connected with the air outlet hole 51 or provided with the air outlet hole 51, in addition, the first channel pipeline is also connected with a branch, the branch is provided with the electromagnetic valve 211 for pipeline exhaust and a pipeline exhaust hole 61, and the first channel pipeline is also connected with the pressure sensor 15; the left side of the second channel pipeline is connected with the electromagnetic valves 26 and 29, the right side of the second channel pipeline is connected with the ablation needle 42, the ablation needle 42 is connected with the air outlet 52 or is provided with the air outlet 52, in addition, the second channel pipeline is also connected with a branch, the branch is provided with an electromagnetic valve 212 for exhausting the pipeline and a pipeline exhaust hole 62, and the second channel pipeline is also connected with the pressure sensor 16; the left side of the third channel pipeline is connected with the electromagnetic valves 25 and 210, the right side of the third channel pipeline is connected with the ablation needle 43, the ablation needle 43 is connected with the air outlet 53 or is provided with the air outlet 53, in addition, the third channel pipeline is also connected with a branch, the branch is provided with an electromagnetic valve 213 for exhausting the pipeline and a pipeline exhaust hole 63, and the third channel pipeline is also connected with a pressure sensor 17.

If the high-pressure freezing of the first channel pipeline (connected to the ablation needle 41) is carried out, nitrogen flows from the nitrogen gas bottle 20 through the electromagnetic valve 21, the pressure reducing valve 32, the electromagnetic valve 23 and the electromagnetic valve 28 to reach the ablation needle 41, and then reaches the air outlet 51 through the air outlet pipe of the ablation needle to be discharged.

If the first channel pipeline (connected with the ablation needle 41) is re-warmed, nitrogen flows from the nitrogen gas bottle 20 through the electromagnetic valve 21, the pressure reducing valve 31, the electromagnetic valve 22 and the electromagnetic valve 27 to reach the ablation needle 41, and then reaches the air outlet 51 through the air outlet pipe of the ablation needle to be discharged.

If a high/low pressure freeze, re-warm of the second/three-way channel line is performed, a similar nitrogen flow path as described above can be obtained with reference to fig. 1.

All the pressure sensors are collectively called pressure sensor 1, and all the solenoid valves are collectively called solenoid valve 2.

Fig. 2 shows a detailed view of the connection of one channel of the pipeline with the ablation needle, and the channel of the channel is connected with the pipeline (an air outlet pipe and an air inlet pipe) in the ablation needle through a locking mechanism. The ablation needle further comprises an electrical interface, and the electrical interface can specifically comprise a temperature sensor wire, a complex temperature thermal resistance wire, an identification interface wire and the like.

In this embodiment, the multi-channel cryoablation system further includes a control circuit board, please refer to fig. 3, and take triple-channel cryoablation shown in fig. 1 as an example, the control circuit board 7 obtains all pressure data measured by all pressure sensors 1 through the pressure measurement module 71, obtains all ablation needle temperature data measured by all temperature sensors 8 through the temperature measurement module 72, controls the switches of the electromagnetic valve 2 and the ablation needle rewarming power supply 9 through the switch module 73, locks the gas interfaces between the ablation needles and the corresponding channel pipelines through the ablation needle locking module 74, and identifies each ablation needle through the ablation needle identification module 75. In this embodiment, all pressure relief valves in FIG. 1 are manually adjusted, and furthermore, all duct vents and air outlets need not be controlled using a control module.

The following illustrates a control method for performing cryoablation therapy by using the multi-channel cryoablation system, which mainly comprises the following steps:

first, ablation needle preparation

Before the formal cryoablation is performed, the ablation needle needs to be prepared, and the preparation of the ablation needle means that the ablation needle is identified as being available by the control circuit board. Before the ablation needle is prepared, the number of the ablation needles to be used is determined according to the volume of tumor tissues.

In this step, each ablation needle is prepared independently, and the ablation needles of the multiple channels do not interfere with each other in the preparation step.

This step requires the corresponding hardware: for 3 ablation needles, 3 respective independent ablation needle identification interfaces, 3 respective independent ablation needle locking interfaces, 3 respective independent ablation needle rewarming power interfaces, and 3 respective independent temperature measurement interfaces need to be equipped. The interface for identifying the ablation needle is used for reading information such as ID (identity) of the ablation needle through the interface equipment, and software in the control circuit board can identify the corresponding ablation needle by using the ID information; the ablation needle locking interface is a gas interface of the ablation needle and corresponding equipment in the multi-channel cryoablation system, and the interface needs to be locked by using a locking structure due to high gas pressure flowing through the ablation needle, so that the ablation needle is prevented from being flushed out during ventilation; the re-warming power interface is an interface between a re-warming resistance wire in the ablation needle and a re-warming power output wire in the equipment; the temperature measurement interface is an interface between a temperature sensor in the ablation needle and a temperature measurement module in the device.

As shown in fig. 4, after the ablation needle preparation step, each ablation needle is marked as prepared or not prepared within the software. The ablation needle preparation process comprises the steps of judging whether a gas interface is locked, whether the temperature of the ablation needle can be collected, whether a rewarming power supply is connected or not, and whether ID identification is available, and marking the ablation needle to be prepared or not by the control circuit board after the judgment. The ablation needle is marked as being prepared, the gas interface is required to be locked, the temperature of the ablation needle can be collected, the rewarming power supply can be switched on, the ID identification can be used, and if any condition is not met, the ablation needle is marked as being not prepared. In fig. 4, the above judging order of the conditions is only an example, and the invention need not be implemented in consideration of the order shown in the judging flow of fig. 4, and the marking result of the ablation needle can be obtained only by completing the judgment of the above four conditions, and the invention is not limited to the judging order of the four conditions.

During the operation stage, the freezing and rewarming control is required to be completed according to the temperature of the ablation needle, so that the temperature of the ablation needle can be acquired when the ablation needle is prepared. If the temperature sensor in the ablation needle breaks down, the temperature measuring module of the control circuit board cannot acquire the temperature of the ablation needle or the acquired temperature value is abnormal through the temperature measuring interface, the ablation needle is marked as being not prepared, and subsequent operation risks can be effectively avoided.

In the rewarming stage, software in the control circuit board starts a rewarming power supply of the ablation needle, and the ablation needle rewrites. The ablation needle uses the rewarming thermal resistance wire to heat and rewarm, and the function is completed on the premise that the thermal resistance wire is intact and not broken. When the ablation needle is prepared, the switch module of the control circuit board can detect the on-off of the hot resistance wire of the ablation needle, so that possible risks are eliminated in advance.

Each ablation needle preparation can be performed with reference to the above method steps, but not every time all ablation needles are required to be prepared, the number of ablation needles to be prepared may be the number of ablation needles to be used, which is determined according to the volume of the tumor tissue.

Second, selection of freezing high pressure line and freezing low pressure line

Gas source pressure is important for multi-channel cryoablation systems. Ideally, the pressure of the nitrogen gas source is as high as possible, but the pressure is limited by the tolerance of the pipeline, the industrial nitrogen gas pressure which can be generally purchased, and the actual gas source pressure should be in a certain range.

For example, with 15MPa (about 2200psi) of industrial nitrogen, the pressure sensor 11 can detect the cylinder pressure after the cylinder 20 is connected to the inlet port (also referred to as the source gas inlet port) of the multi-channel cryoablation system. Along with the use of nitrogen gas in the operation, the pressure of the gas cylinder can be gradually reduced, and when the pressure is lower than the lower limit pressure value, the ablation needle cannot reach the operation temperature, the operation cannot be continued, and the fact that the pressure of the gas cylinder is low and the operation cannot be performed is prompted.

For the multi-channel cryoablation system of the present invention, the lower pressure limit is different when different numbers of ablation needles are used simultaneously. The more the number of the ablation needles used at the same time, the higher the lower limit pressure value.

The gas pressure in the freezing high-pressure pipeline is controlled by using a pressure reducing valve 32, and the pressure reducing valve 32 is adjusted to enable the output gas pressure to be the lower limit pressure value 1;

the gas pressure in the low-pressure freezing pipeline is controlled by using a pressure reducing valve 33, and the pressure reducing valve 33 is adjusted to make the output gas pressure be the lower limit pressure value 2.

As can be seen from the foregoing, the lower limit pressure value 2 of the freezing low-pressure pipeline is less than the lower limit pressure value 1 of the freezing high-pressure pipeline is less than the cylinder pressure.

Therefore, in the present embodiment, when 3 ablation needles are used simultaneously, a freezing high-pressure pipeline is used; when less than 3 ablation needles are used simultaneously, a cryo-low pressure line should be used.

Therefore, after the preparation of the ablation needles in the previous step is completed, the number of the ablation needles to be used is determined according to the volume of the tumor tissue, and the software of the control circuit board can judge the number of the ablation needles prepared in the preparation stage of the ablation needles and select the freezing high-pressure pipeline or the freezing low-pressure pipeline.

For the rewarming pipeline, the pressure reducing valve 31 is used to control the gas pressure in the pipeline, and the pressure reducing valve 31 is adjusted to make the output gas pressure be the lower limit pressure value 3, wherein the lower limit pressure value 3 is far lower than the lower limit pressure value 2. Usually, the situation that the pressure of the rewarming gas is not enough in the operation stage does not exist, and the rewarming requirement can be met only if the pressure of the gas cylinder can meet the freezing requirement, so that the selection of the rewarming pressure is not needed.

Third, use of an ablation needle

The situation that three ablation needles are used simultaneously covers the situation that one ablation needle is used independently due to the control complexity. The following description will be given by taking the simultaneous use of only three ablation needles as an example.

The three ablation needles are used simultaneously, the function of each ablation needle corresponding to a channel is independent, and each channel is provided with freezing, rewarming and exhausting steps. As mentioned in the previous step, three ablation needles are used simultaneously, and a freezing high-pressure pipeline is used for freezing.

The freezing, rewarming and venting processes of the ablation needle 41 will be described with reference to fig. 1 and 5.

Freezing of the ablation needle 41: the electromagnetic valves 21, 23 and 28 are opened, and nitrogen gas flows from the nitrogen gas bottle 20, flows through the electromagnetic valve 21 to the pressure reducing valve 32 (high-pressure pipeline), then reaches the electromagnetic valve 23, reaches the ablation needle 41 through the electromagnetic valve 28, and then reaches the air outlet 51 through the ablation needle air outlet pipe to be discharged.

Rewarming the ablation needle 41: the electromagnetic valves 21, 22 and 27 are opened, and nitrogen flows from the nitrogen gas bottle 20, flows through the electromagnetic valve 21 to the pressure reducing valve 31, then flows through the electromagnetic valve 22, reaches the ablation needle 41 through the electromagnetic valve 27, and then reaches the air outlet 51 through the ablation needle air outlet pipe to be discharged.

Exhausting by the ablation needle 41: the exhaust means to exhaust the residual high pressure gas in the channel pipeline, and the gas is exhausted through the outlet pipe of the ablation needle during freezing and rewarming, but the gas in the channel pipeline cannot be exhausted, where the channel pipeline refers to the pipeline cut by the electromagnetic valves 27 and 28 and the inlet pipe in the ablation needle 41, and the pipeline is provided with the pipeline exhaust hole 61, the electromagnetic valve 211 and the pressure sensor 15, as shown in fig. 5. When the channel pipe is exhausted, the electromagnetic valves 27 and 28 are closed, the electromagnetic valve 211 is opened, and the gas in the channel pipe can be exhausted through the pipe exhaust hole 61. Exhaust is an auxiliary function that may be used in various stages. For example, venting should occur before an operation to unlock the ablation needle gas interface is performed. Further, an air exhausting operation may be performed immediately after the freezing function or the rewarming function is completed.

As can be seen from the above, in the case of using three ablation needles, the gas cylinder 20, the solenoid valve 21, the solenoid valve 22, and the solenoid valve 23 are common to different functions of the gas passages of the three ablation needles, and the freezing, rewarming, and exhausting functions cannot be used simultaneously for the same gas passage of the ablation needle. Due to the above limitations, the control complexity of each electromagnetic valve in the system is increased, and the control method of each electromagnetic valve needs to ensure that the equipment can complete the expected function, and is convenient and quick.

Fig. 6 shows a solenoid valve control flow, in fig. 6, a channel 1 indicates a channel of the ablation needle 41, a channel 2 indicates a channel of the ablation needle 42, a channel 3 indicates a channel of the ablation needle 43, and "/" in fig. 6 represents "and".

As shown in fig. 6, if the freezing of the channel 1 needs to be stopped, the electromagnetic valves 21, 23, 28 cannot be directly closed, and it is first necessary to confirm whether the channels 2, 3 are freezing, and if the channels 2, 3 are freezing, it is stated that the electromagnetic valves 21, 23 are also opened, and at this time, the freezing of the channel 1 can be stopped only by closing the electromagnetic valve 28; if the channels 2 and 3 are not frozen, whether the channels 2 and 3 are in rewarming or not needs to be confirmed, if the channels 2 and 3 are in rewarming, the electromagnetic valve 21 is opened, and at the moment, the freezing of the channel 1 is stopped, and only the electromagnetic valves 23 and 28 can be closed; if neither freeze nor rewarming of the passages 2, 3 is present, stopping freeze to passage 1 closes the solenoid valves 21, 23, 28.

Referring to fig. 5 in combination, if the rewarming of the channel 1 needs to be stopped, the electromagnetic valves 21, 22 and 27 cannot be directly closed, it is first necessary to determine whether the channels 2 and 3 are rewarming, if the channels 2 and 3 are rewarming, it is described that the electromagnetic valves 21 and 22 are also opened, and at this time, the rewarming of the channel 1 is stopped, and only the electromagnetic valve 27 is closed; if the channels 2 and 3 are not rewarmed, whether the channels 2 and 3 are freezing or not needs to be confirmed, if the channels 2 and 3 are freezing, the electromagnetic valve 21 is opened, and at the moment, the rewarming of the channel 1 is stopped, and only the electromagnetic valves 22 and 27 can be closed; stopping the rewarming of lane 1 closes solenoid valves 21, 22, 27 if lanes 2, 3 are neither frozen nor rewarmed.

The use of the venting function of the ablation needle is described in detail below.

The freezing and rewarming functions are basic functions of the cryoablation operation, and the air exhausting function is also described in the using steps of the ablation needle. Exhaust is an auxiliary function that may be used in various stages.

Referring to fig. 5, the channel pipeline of the exhaust function requiring exhaust gas is a tee joint, which connects the freezing pipeline and the rewarming pipeline of the channel 1 and the air inlet pipeline of the ablation needle 41 at the same time. When residual high-pressure gas is present in the channel line, the gas interface of the ablation needle and the device cannot be unlocked, because the ablation needle may be flushed out after unlocking. Therefore, venting should be performed before the operation of unlocking the ablation needle gas interface is performed.

In addition, the freezing function and the rewarming function have different lower limit pressure values corresponding to the pressure reducing valve, which means that the residual gas pressure in the passage pipe is different, and the residual gas pressure after the freezing function is finished is higher than the residual gas pressure after the rewarming is finished. If the rewarming function is activated immediately after the freezing function is finished, a failure occurs in which the pressure at the output port of the pressure reducing valve 31 is briefly higher than its actual output pressure due to residual gas in the passage line. Based on the above, an air exhausting operation can be performed immediately after the freezing function or the rewarming function is completed.

The control method of the present embodiment further includes the use of a pressure sensor.

Specifically, the pressure sensor 11 is used for detecting the pressure of the nitrogen gas cylinder, and when the pressure value of the nitrogen gas cylinder is lower than the lower limit pressure value 1 or the lower limit pressure value 2, the control method of the invention prompts that the operation can not be continued through the control circuit board.

The pressure sensors 12, 13, 14 are used for detecting the output pressure of the corresponding pressure reducing valve, and when the output pressure of the pressure reducing valve is manually adjusted, the output pressure value can be fed back to an adjuster, so that the output pressure of the pressure reducing valve can be conveniently adjusted. Meanwhile, after the pressure reducing valve is adjusted, the control circuit board can judge whether the output pressure value of the pressure reducing valve detected by the pressure sensor is in a preset range or not, and further judge the fault of the corresponding pressure reducing valve.

The pressure sensors 15, 16, 17 are used to detect the pressure values of the respective channel lines. When the freezing and rewarming functions are executed, whether the gas reaches the position can be judged according to the detected pressure value. If the pipe becomes blocked, gas may not reach this point. Further, the exhaust process can be judged based on the pressure values detected by the pressure sensors 15, 16, 17, and when the exhaust function is performed, when the pressure value detected by the pressure sensor approaches 0, it is known that the gas in the corresponding exhaust pipe is exhausted.

The control method can be realized by software built in the control circuit board.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention. The invention is limited only by the claims and their full scope and equivalents.