阅读说明：本技术 用于光动力治疗的激光精准照射系统及方法 (Laser accurate irradiation system and method for photodynamic therapy ) 是由 陈德福 刘莹 顾瑛 邱海霞 杨健 于 2021-08-24 设计创作，主要内容包括：用于光动力治疗的激光精准照射系统及方法,能够实现光斑对黏膜组织病灶的精准覆盖,进一步提高光动力疗法的疗效,减小副作用。诊断激光经长波通二向色镜的反射和透镜的透射照射到病灶(7),激发出荧光,荧光再经透镜、长波通二向色镜、长波通滤光片进入CCD相机,经CCD相机成像在计算机系统的屏幕上,得到病灶图像；对病灶图像进行图像处理,划定治疗范围,建立二维治疗坐标系,确定哪些坐标点需要照光哪些坐标点不需要,以及不同患病级别照光坐标点设置不同光强；治疗激光经过反射镜、长波通二向色镜、光斑调节部分出射,同步控制器使检流计振镜系统偏转与治疗激光出射同步进行。(The laser accurate irradiation system and method for photodynamic therapy can realize accurate coverage of light spots on mucous membrane tissue focuses, further improve the curative effect of the photodynamic therapy and reduce side effects. The diagnostic laser irradiates a focus (7) through the reflection of the long-wave-pass dichroic mirror and the transmission of the lens, so as to excite fluorescence, the fluorescence enters the CCD camera through the lens, the long-wave-pass dichroic mirror and the long-wave-pass optical filter, and is imaged on a screen of a computer system through the CCD camera, so as to obtain a focus image; processing the focus image, defining a treatment range, establishing a two-dimensional treatment coordinate system, determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated, and setting different light intensities for the irradiation coordinate points with different disease levels; the therapeutic laser is emitted through the reflector, the long-wave-pass dichroic mirror and the light spot adjusting part, and the synchronous controller enables the galvanometer system to deflect and emit the therapeutic laser synchronously.)

1. A accurate irradiation system of laser for photodynamic treatment which characterized in that: it includes: the device comprises a computer system (1), diagnostic laser (2), a CCD camera (3), a long-wave pass filter (4), a long-wave pass dichroic mirror (5), a lens (6), a synchronous controller (8), therapeutic laser, a reflecting mirror (12), the long-wave pass dichroic mirror, a light spot adjusting part (15) and a galvanometer mirror system (16);

the diagnostic laser irradiates a focus (7) through the reflection of the long-wave-pass dichroic mirror and the transmission of the lens, so as to excite fluorescence, the fluorescence enters the CCD camera through the lens, the long-wave-pass dichroic mirror and the long-wave-pass optical filter, and is imaged on a screen of a computer system through the CCD camera, so as to obtain a focus image; processing the focus image, defining a treatment range, establishing a two-dimensional treatment coordinate system, determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated, and setting different light intensities for the irradiation coordinate points with different disease levels; the therapeutic laser is emitted through the reflector, the long-wave-pass dichroic mirror and the light spot adjusting part, and the synchronous controller enables the galvanometer system to deflect and emit the therapeutic laser synchronously.

2. The laser precision irradiation system for photodynamic therapy according to claim 1, characterized in that: the wavelength of the diagnostic laser is 405 nm.

3. The laser precision irradiation system for photodynamic therapy according to claim 2, characterized in that: the synchronous controller synchronously triggers the galvanometer vibrating mirror system and the treatment laser, so that the galvanometer vibrating mirror deflection and the treatment laser emission are synchronously carried out, and the treatment laser is emitted according to corresponding synchronous time sequence.

4. The laser precision irradiation system for photodynamic therapy according to claim 3, characterized in that: the galvanometer mirror system includes: the X-axis vibration mirror system comprises an X-axis driving circuit, an X-axis driving motor (16-1), an X-axis lens (16-2), a Y-axis driving circuit, a Y-axis driving motor (16-3) and a Y-axis lens (16-4), wherein an X-axis vibration mirror and the Y-axis vibration mirror are orthogonally arranged, and the relation between a focus coordinate point and the voltage for driving the X-axis vibration mirror system and the Y-axis vibration mirror system is obtained according to the vertical distance between the two vibration mirrors and the distance between the vibration mirror and a focus, so that the deflection angle of the vibration mirror is changed by changing the driving voltage.

5. The laser precision irradiation system for photodynamic therapy according to claim 4, characterized in that: the treatment laser comprises: first (9), second (10), third (11) treatment laser light, the long wave pass dichroic mirror includes: a first long-wave-pass dichroic mirror (13), a second long-wave-pass dichroic mirror (14); the wavelength of the first therapeutic laser (9) is 660nm, and the first therapeutic laser is reflected by a reflecting mirror (12) and is transmitted by a first long-wave-pass dichroic mirror (13) and a second long-wave-pass dichroic mirror (14); the wavelength of the second treatment laser (10) is 630nm, and the second treatment laser is reflected by the first long-wave-pass dichroic mirror (13) and transmitted by the second long-wave-pass dichroic mirror (14); the wavelength of the third therapeutic laser (11) is 532nm, and the third therapeutic laser is reflected by the dichroic mirror (14) through the second long wave; the direction and position of the three kinds of emergent light are the same.

6. The laser precision irradiation system for photodynamic therapy according to claim 5, characterized in that: the light spot adjusting part comprises a beam expanding system and an adjustable diaphragm; the beam expansion system uses an inverted galilean telescopic system; firstly, selecting proper focal length of the lens according to requirements to make the beam expansion ratio as large as possible and to make the laser spot after passing through the beam expansion system as large as possible, then dividing the treatment range into a certain number of coordinate points according to the requirements, finally, adjusting the variable diaphragm to adjust the spot adjusting part into the spot size corresponding to the spot adjusting part.

7. The laser accurate irradiation method for photodynamic therapy is characterized by comprising the following steps: which comprises the following steps:

(1) the diagnostic laser irradiates a focus through the reflection of the long-wave-pass dichroic mirror and the transmission of the lens, excites fluorescence, the fluorescence enters the CCD camera through the lens, the long-wave-pass dichroic mirror and the long-wave-pass optical filter, and is imaged on a screen of a computer system through the CCD camera to obtain a focus image;

(2) carrying out image processing on the focus image to obtain refined division of the focus, distinguishing a diseased part and a healthy part of the focus, and carrying out disease grade evaluation on different areas of the diseased part;

(3) according to the specific characteristics of the focus image after image processing, a treatment range is defined, one point is selected as an origin, and a two-dimensional treatment coordinate system is established;

(4) dividing the treatment range into a certain number of coordinate points according to a certain size, and adjusting the light spot adjusting part into the corresponding light spot size;

(5) selecting treatment laser with proper wavelength according to needs and determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated according to the evaluation result of the disease level, and setting different light intensities for the irradiation coordinate points with different disease levels;

(6) the synchronous controller synchronously triggers the galvanometer system and the treatment laser, so that the galvanometer deflection and the treatment laser emission are synchronously carried out, the treatment laser is emitted according to a corresponding synchronous time sequence, and the treatment laser is accurately irradiated on a coordinate point of a mucous membrane tissue focus until the focus part is irradiated.

8. The laser precision irradiation method for photodynamic therapy according to claim 7, characterized in that: in the step (4), segmentation is performed according to specific characteristics of the focus, light spots covering the focus are customized according to the segmentation number and the segmentation size, and one large light spot is used for covering the focus or a plurality of small light spots are used for scanning the focus.

9. The laser precision irradiation method for photodynamic therapy according to claim 8, characterized in that: in the step (4), segmentation is performed according to specific characteristics of the focus, and if the focus is large and round in shape, the number of segmentation is small, the light spot is large, and if the focus is sharp and complex in shape, the number of segmentation is large, and the light spot is small.

10. The laser precision irradiation method for photodynamic therapy according to claim 9, characterized in that: in the step (6), the treatment laser includes: first (9), second (10), third (11) treatment laser light, the long wave pass dichroic mirror includes: a first long-wave-pass dichroic mirror (13), a second long-wave-pass dichroic mirror (14); the wavelength of the first therapeutic laser (9) is 660nm, and the first therapeutic laser is reflected by a reflecting mirror (12) and is transmitted by a first long-wave-pass dichroic mirror (13) and a second long-wave-pass dichroic mirror (14); the wavelength of the second treatment laser (10) is 630nm, and the second treatment laser is reflected by the first long-wave-pass dichroic mirror (13) and transmitted by the second long-wave-pass dichroic mirror (14); the wavelength of the third therapeutic laser (11) is 532nm, and the third therapeutic laser is reflected by the dichroic mirror (14) through the second long wave; the direction and position of the three kinds of emergent light are the same.

Technical Field

The invention relates to the technical field of photoelectric detection, in particular to a laser accurate irradiation system for photodynamic therapy and a method adopted by the laser accurate irradiation system for the photodynamic therapy.

Background

The photodynamic therapy is a novel minimally invasive therapy for treating tumors after surgery, radiotherapy and chemotherapy. The photodynamic therapy is characterized in that a photosensitizer is administered to a patient in a local coating or intravenous injection mode, the photosensitizer irradiates a focus with laser after administration for a certain time, and the photosensitizer generates active oxygen with cytotoxicity after excitation so as to kill focus cells. The photodynamic therapy integrates the advantages of high selectivity, small wound, safety, repeatable treatment, no drug resistance and the like, has incomparable advantages of the traditional therapy, does not need to excise diseased tissues, and can protect the structure and the function of tissues and organs to the maximum extent.

Therapeutic light and photosensitizers are two major essential elements of photodynamic therapy. Numerous tumor lesions are irregularly distributed, and the traditional circular light spot irradiation adopted by the photodynamic therapy cannot accurately cover the focus area, so that the curative effect of the photodynamic therapy is poor, and even normal tissue damage is caused.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention provides a laser precise irradiation system for photodynamic therapy, which can realize precise coverage of light spots on focuses, further improve the curative effect of the photodynamic therapy and reduce side effects.

The technical scheme of the invention is as follows: the laser precision irradiation system for photodynamic therapy comprises: the device comprises a computer system (1), diagnostic laser (2), a CCD camera (3), a long-wave pass filter (4), a long-wave pass dichroic mirror (5), a lens (6), a synchronous controller (8), therapeutic laser, a reflecting mirror (12), the long-wave pass dichroic mirror, a light spot adjusting part (15) and a galvanometer mirror system (16);

the diagnostic laser irradiates a focus (7) through the reflection of the long-wave-pass dichroic mirror and the transmission of the lens, so as to excite fluorescence, the fluorescence enters the CCD camera through the lens, the long-wave-pass dichroic mirror and the long-wave-pass optical filter, and is imaged on a screen of a computer system through the CCD camera, so as to obtain a focus image; processing the focus image, defining a treatment range, establishing a two-dimensional treatment coordinate system, determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated, and setting different light intensities for the irradiation coordinate points with different disease levels; the therapeutic laser is emitted through the reflector, the long-wave-pass dichroic mirror and the light spot adjusting part, and the synchronous controller enables the galvanometer system to deflect and emit the therapeutic laser synchronously.

The invention irradiates focus tissues by diagnostic laser, excites fluorescence, and images on a computer screen by a CCD camera to obtain a focus image; processing the focus image, defining a treatment range, establishing a two-dimensional treatment coordinate system, determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated, and setting different light intensities for the irradiation coordinate points with different disease levels; the synchronous controller makes the deflection of the galvanometer vibrating mirror and the emission of the treatment laser synchronously carried out; therefore, the accurate coverage of the focus by the light spots can be realized, the curative effect of the photodynamic therapy is further improved, and the side effect is reduced.

Also provided is a laser precision irradiation method for photodynamic therapy, which comprises the following steps:

(1) the diagnostic laser irradiates a focus through the reflection of the long-wave-pass dichroic mirror and the transmission of the lens, excites fluorescence, the fluorescence enters the CCD camera through the lens, the long-wave-pass dichroic mirror and the long-wave-pass optical filter, and is imaged on a screen of a computer system through the CCD camera to obtain a focus image;

(2) carrying out image processing on the focus image to obtain refined division of the focus, distinguishing a diseased part and a healthy part of the focus, and carrying out disease grade evaluation on different areas of the diseased part;

(3) according to the specific characteristics of the focus image after image processing, a treatment range is defined, one point is selected as an origin, and a two-dimensional treatment coordinate system is established;

(4) dividing the treatment range into a certain number of coordinate points according to a certain size, and adjusting the light spot adjusting part into the corresponding light spot size;

(5) selecting treatment laser with proper wavelength according to needs and determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated according to the evaluation result of the disease level, and setting different light intensities for the irradiation coordinate points with different disease levels;

(6) the synchronous controller synchronously triggers the galvanometer system and the treatment laser, so that the galvanometer deflection and the treatment laser emission are synchronously carried out, the treatment laser is emitted according to a corresponding synchronous time sequence, and the treatment laser is accurately irradiated on a coordinate point of a mucous membrane tissue focus until the focus part is irradiated.

Drawings

Fig. 1 shows a schematic structural diagram of a laser precision irradiation system for photodynamic therapy according to the present invention.

Fig. 2 is a schematic structural diagram illustrating a spot adjusting part of a laser precision irradiation system for photodynamic therapy according to the present invention.

Fig. 3 shows a schematic structural diagram of a galvanometer mirror system of a laser precision irradiation system for photodynamic therapy according to the invention.

Fig. 4 is a view illustrating an example of an image-processed lesion image of a laser precision irradiation system for photodynamic therapy according to the present invention.

Fig. 5 is a timing diagram illustrating a galvanometer mirror and laser synchronous triggering of a laser precision irradiation system for photodynamic therapy according to the present invention.

Fig. 6 shows a flowchart of a laser precision irradiation method for photodynamic therapy according to the present invention.

Detailed Description

In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that the term "comprises/comprising" and any variations thereof in the description and claims of the present invention and the above-described drawings is intended to cover non-exclusive inclusions, such that a process, method, apparatus, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

As shown in fig. 1, the laser precision irradiation system for photodynamic therapy includes: the device comprises a computer system (1), diagnostic laser (2), a CCD camera (3), a long-wave pass filter (4), a long-wave pass dichroic mirror (5), a lens (6), a synchronous controller (8), therapeutic laser, a reflecting mirror (12), the long-wave pass dichroic mirror, a light spot adjusting part (15) and a galvanometer mirror system (16);

the diagnostic laser irradiates a focus (7) through the reflection of the long-wave-pass dichroic mirror and the transmission of the lens, so as to excite fluorescence, the fluorescence enters the CCD camera through the lens, the long-wave-pass dichroic mirror and the long-wave-pass optical filter, and is imaged on a screen of a computer system through the CCD camera, so as to obtain a focus image; processing the focus image, defining a treatment range, establishing a two-dimensional treatment coordinate system, determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated, and setting different light intensities for the irradiation coordinate points with different disease levels; the therapeutic laser is emitted through the reflector, the long-wave-pass dichroic mirror and the light spot adjusting part, and the synchronous controller enables the galvanometer system to deflect and emit the therapeutic laser synchronously.

The invention irradiates focus tissues by diagnostic laser, excites fluorescence, and images on a computer screen by a CCD camera to obtain a focus image; processing the focus image, defining a treatment range, establishing a two-dimensional treatment coordinate system, determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated, and setting different light intensities for the irradiation coordinate points with different disease levels; the synchronous controller makes the deflection of the galvanometer vibrating mirror and the emission of the treatment laser synchronously carried out; therefore, the accurate coverage of the focus by the light spots can be realized, the curative effect of the photodynamic therapy is further improved, and the side effect is reduced.

Preferably, the diagnostic laser has a wavelength of 405 nm.

Preferably, the synchronous controller synchronously triggers the galvanometer vibrating mirror system and the treatment laser, so that the deflection of the galvanometer vibrating mirror and the emission of the treatment laser are synchronously carried out, and the treatment laser is emitted according to corresponding synchronous time sequence.

Preferably, the galvanometer mirror system comprises: the X-axis vibration mirror system comprises an X-axis driving circuit, an X-axis driving motor (16-1), an X-axis lens (16-2), a Y-axis driving circuit, a Y-axis driving motor (16-3) and a Y-axis lens (16-4), wherein an X-axis vibration mirror and the Y-axis vibration mirror are orthogonally arranged, and the relation between a focus coordinate point and the voltage for driving the X-axis vibration mirror system and the Y-axis vibration mirror system is obtained according to the vertical distance between the two vibration mirrors and the distance between the vibration mirror and a focus, so that the deflection angle of the vibration mirror is changed by changing the driving voltage.

Preferably, the treatment laser comprises: first (9), second (10), third (11) treatment laser light, the long wave pass dichroic mirror includes: a first long-wave-pass dichroic mirror (13), a second long-wave-pass dichroic mirror (14); the wavelength of the first therapeutic laser (9) is 660nm, and the first therapeutic laser is reflected by a reflecting mirror (12) and is transmitted by a first long-wave-pass dichroic mirror (13) and a second long-wave-pass dichroic mirror (14); the wavelength of the second treatment laser (10) is 630nm, and the second treatment laser is reflected by the first long-wave-pass dichroic mirror (13) and transmitted by the second long-wave-pass dichroic mirror (14); the wavelength of the third therapeutic laser (11) is 532nm, and the third therapeutic laser is reflected by the dichroic mirror (14) through the second long wave; the direction and position of the three kinds of emergent light are the same.

Preferably, the light spot adjusting part comprises beam expanding systems (15-1, 15-2) and an adjustable diaphragm (15-3); the beam expansion system uses an inverted galilean telescopic system; firstly, selecting proper focal length of the lens according to requirements to make the beam expansion ratio as large as possible and to make the laser spot after passing through the beam expansion system as large as possible, then dividing the treatment range into a certain number of coordinate points according to the requirements, finally, adjusting the variable diaphragm to adjust the spot adjusting part into the spot size corresponding to the spot adjusting part.

As shown in fig. 6, there is also provided a laser precision irradiation method for photodynamic therapy, which includes the following steps:

(1) the diagnostic laser irradiates a focus through the reflection of the long-wave-pass dichroic mirror and the transmission of the lens, excites fluorescence, the fluorescence enters the CCD camera through the lens, the long-wave-pass dichroic mirror and the long-wave-pass optical filter, and is imaged on a screen of a computer system through the CCD camera to obtain a focus image;

(2) carrying out image processing on the focus image to obtain refined division of the focus, distinguishing a diseased part and a healthy part of the focus, and carrying out disease grade evaluation on different areas of the diseased part;

(3) according to the specific characteristics of the focus image after image processing, a treatment range is defined, one point is selected as an origin, and a two-dimensional treatment coordinate system is established;

(4) dividing the treatment range into a certain number of coordinate points according to a certain size, and adjusting the light spot adjusting part into the corresponding light spot size;

(5) selecting treatment laser with proper wavelength according to needs and determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated according to the evaluation result of the disease level, and setting different light intensities for the irradiation coordinate points with different disease levels;

(6) the synchronous controller synchronously triggers the galvanometer system and the treatment laser, so that the galvanometer deflection and the treatment laser emission are synchronously carried out, the treatment laser is emitted according to a corresponding synchronous time sequence, and the treatment laser is accurately irradiated on a coordinate point of a mucous membrane tissue focus until the focus part is irradiated.

Preferably, in the step (4), segmentation is performed according to specific features of the lesion, spots covering the lesion are customized according to the number of the segmentation and the segmentation size, and one large spot is used to cover the lesion or a plurality of small spots are used to scan the lesion.

Preferably, in the step (4), the segmentation is performed according to specific characteristics of the lesion, and if the lesion has a large and round shape, the number of segmentation is small, the light spot is large, and if the lesion has a sharp and complex shape, the number of segmentation is large, and the light spot is small.

Preferably, in the step (6), the treatment laser includes: first (9), second (10), third (11) treatment laser light, the long wave pass dichroic mirror includes: a first long-wave-pass dichroic mirror (13), a second long-wave-pass dichroic mirror (14); the wavelength of the first therapeutic laser (9) is 660nm, and the first therapeutic laser is reflected by a reflecting mirror (12) and is transmitted by a first long-wave-pass dichroic mirror (13) and a second long-wave-pass dichroic mirror (14); the wavelength of the second treatment laser (10) is 630nm, and the second treatment laser is reflected by the first long-wave-pass dichroic mirror (13) and transmitted by the second long-wave-pass dichroic mirror (14); the wavelength of the third therapeutic laser (11) is 532nm, and the third therapeutic laser is reflected by the dichroic mirror (14) through the second long wave; the direction and position of the three kinds of emergent light are the same.

Specific examples of the present invention are described in detail below.

When the lesion tissues are diagnosed, the fluorescence excitation is carried out by using diagnostic laser with the wavelength of 405 nm. The diagnostic laser (2) is reflected by the long-wave-pass dichroic mirror (5) and transmitted by the lens (6) to irradiate the focal tissues, fluorescence is excited, then enters the CCD camera through the lens (6), the long-wave-pass dichroic mirror (5) and the long-wave-pass optical filter (4), and is imaged on a computer screen through the CCD camera to obtain a focal image. And carrying out image processing on the focus image to obtain refined division of the focus, distinguishing a diseased part and a healthy part of the focus, and carrying out disease grade evaluation on different areas of the diseased part. According to the specific characteristics of the focus image after image processing, a treatment range is defined, a proper point is selected as an origin, and a two-dimensional treatment coordinate system is established. The treatment range is divided into a certain number of coordinate points according to a certain size, and the coordinate points are divided according to the specific characteristics of the focus, wherein the focus is large in shape and round, the division number is small, the light spot is large, the focus is sharp and complex in shape, the division number is large, and the light spot is small. According to the segmentation quantity and the segmentation size, the light spots covering the focus are customized, one large light spot can be used for covering the focus, and a plurality of small light spots can be used for scanning the focus. The light spot adjusting part comprises a beam expanding system and an adjustable diaphragm. An inverted galilean telescopic system is used in the apparatus as the beam expanding system. Firstly, selecting proper focal length of the lens according to requirements, enabling the beam expansion ratio to be as large as possible, enabling laser spots passing through the beam expansion system to be as large as possible, and finally, adjusting the iris diaphragm to be in the size of the corresponding laser spots. And selecting the treatment laser with proper wavelength according to the requirement, wherein the wavelength of the treatment laser (9) can be 660nm, the wavelength of the treatment laser (10) can be 630nm, and the wavelength of the treatment laser (11) can be 532 nm. Therapeutic laser with the wavelength of 660nm is selected, and is reflected by a reflecting mirror (12), and a long-wave-pass dichroic mirror (13) and a long-wave-pass dichroic mirror (14) are transmitted; selecting treatment laser with the wavelength of 630nm, reflecting the treatment laser by a long-wave-pass dichroic mirror (13), and transmitting the treatment laser by a long-wave-pass dichroic mirror (14); the treatment laser with the wavelength of 532nm is selected and needs to be reflected by a long-wave-pass dichroic mirror (14). The treatment laser is selected to be different, but the position of the emitting direction is not changed. And determining which coordinate points need to be illuminated and which coordinate points do not need to be illuminated according to the disease level evaluation result, and setting different light intensities for the illumination coordinate points with different disease levels. The synchronous controller synchronously triggers the galvanometer vibrating mirror system and the treatment laser, so that the galvanometer vibrating mirror deflection and the treatment laser emission are synchronously carried out, and the treatment laser is emitted according to corresponding synchronous time sequence. The galvanometer mirror vibrating system comprises an X-axis driving circuit, an X-axis driving motor (16-1), an X-axis lens (16-2), a Y-axis driving circuit, a Y-axis driving motor (16-3) and a Y-axis lens (16-4), wherein the X-axis mirror vibrating system and the Y-axis mirror vibrating system are orthogonally placed, and the relation between a focus coordinate point and the voltage for driving the X-axis mirror vibrating system and the Y-axis mirror vibrating system is obtained according to the vertical distance between the two mirrors and the distance between the mirrors and the focus, so that the deflection angle of the mirrors is changed by changing the driving voltage.

Example 1: the focus tissue is oral mucosa tissue

The diagnostic laser (2) is reflected by the long-wave-pass dichroic mirror (5) and transmitted by the lens (6) to irradiate the focus tissue of the oral mucosa, fluorescence is excited, then enters the CCD camera through the lens (6), the long-wave-pass dichroic mirror (5) and the long-wave-pass optical filter (4), and is imaged on a computer screen through the CCD camera, so that an image of the focus tissue of the oral mucosa is obtained. And carrying out image processing on the focus image to obtain refined division of the focus, distinguishing a diseased part and a healthy part of the focus, and carrying out disease grade evaluation on different areas of the diseased part. According to the specific characteristics of the focus image after image processing, a treatment range is defined, a proper point is selected as an origin, and a two-dimensional treatment coordinate system is established. The therapeutic range is divided into a certain number of coordinate points according to a certain size, and the light spot adjusting part is adjusted to the corresponding light spot size. According to the requirements, selecting the treatment laser with proper wavelength and according to the disease level evaluation result, determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated, and setting different light intensities for the irradiation coordinate points with different disease levels.

The synchronous controller synchronously triggers the galvanometer vibrating mirror system and the treatment laser, so that the galvanometer vibrating mirror deflection and the treatment laser emission are synchronously carried out, the treatment laser is emitted according to a corresponding synchronous time sequence, and the treatment laser accurately irradiates a focus coordinate point of oral mucosa tissue until the focus position is irradiated.

The treated oral mucosa tissue has good curative effect and no damage to normal tissue.

Example 2: the focus tissue is cervical mucosa tissue

The diagnosis laser (2) is reflected by the long-wave-pass dichroic mirror (5) and transmitted by the lens (6) to irradiate the cervical mucosa focal tissue, fluorescence is excited, then enters the CCD camera through the lens (6), the long-wave-pass dichroic mirror (5) and the long-wave-pass optical filter (4), and is imaged on a computer screen through the CCD camera, and the cervical mucosa focal tissue image is obtained. And carrying out image processing on the focus image to obtain refined division of the focus, distinguishing a diseased part and a healthy part of the focus, and carrying out disease grade evaluation on different areas of the diseased part. According to the specific characteristics of the focus image after image processing, a treatment range is defined, a proper point is selected as an origin, and a two-dimensional treatment coordinate system is established. The therapeutic range is divided into a certain number of coordinate points according to a certain size, and the light spot adjusting part is adjusted to the corresponding light spot size. According to the requirements, selecting the treatment laser with proper wavelength and according to the disease level evaluation result, determining which coordinate points need to be irradiated and which coordinate points do not need to be irradiated, and setting different light intensities for the irradiation coordinate points with different disease levels.

The synchronous controller synchronously triggers the galvanometer system and the treatment laser to enable the galvanometer deflection and the treatment laser to be synchronously emitted, the treatment laser is emitted according to a corresponding synchronous time sequence, and the treatment laser is accurately irradiated on a lesion coordinate point of cervical mucosa tissue until the lesion part is irradiated.

The treated cervical mucosa tissue has good curative effect and no damage to normal tissues.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and all simple modifications, equivalent variations and modifications made to the above embodiment according to the technical spirit of the present invention still belong to the protection scope of the technical solution of the present invention.