阅读说明：本技术 病理药物作用监测系统及方法 (Pathological drug action monitoring system and method ) 是由 张弟龙 谢永 袁琴 张艺川 殷冲 李欣 于 2021-08-31 设计创作，主要内容包括：本发明涉及药物筛选技术领域,具体为一种病理药物作用监测系统及方法,其中系统包括：数据库存储生物大分子模型、药物分子模型和生物大分子的分子动力学模型；仿真加载模块根据调取的模型,进行仿真,形成药物作用下的分子运动过程；三维模型模块根据分子运动过程,建立三维可视化模型；数据提取分析模块提取分子运动过程中的关键数据,进行计算处理；药物作用分析模块根据计算处理的结果,分析药物作用；验证分析模块根据分析出的药物作用,查询相关的验证资料,判断药物作用中符合验证资料的条数占比,根据条数占比,定义药物作用可信度。本方案能降低开发成本,直观反应药物作用下的分子运动,帮助研究人员进行判断分析。(The invention relates to the technical field of drug screening, in particular to a pathological drug action monitoring system and a method, wherein the system comprises: the database stores a biological macromolecule model, a drug molecule model and a biological macromolecule molecular dynamics model; the simulation loading module simulates according to the called model to form a molecular motion process under the action of the medicine; the three-dimensional model module establishes a three-dimensional visual model according to the molecular motion process; the data extraction and analysis module extracts key data in the molecular motion process and carries out calculation processing; the drug action analysis module analyzes the drug action according to the calculation and processing result; the verification analysis module inquires related verification data according to the analyzed drug action, judges the number ratio of the drug action according with the verification data, and defines the drug action reliability according to the number ratio. The scheme can reduce development cost, visually reflect molecular motion under the action of the drug and help researchers to judge and analyze.)

1. Pathological drug action monitoring system, its characterized in that: the method comprises the following steps: the system comprises a database, a selection module, a simulation loading module, a three-dimensional model module, a data extraction and analysis module, a drug action analysis module and a verification and analysis module;

the database is used for storing a biological macromolecule model, a drug molecule model and a biological macromolecule molecular dynamics model, wherein the drug molecule model comprises drug molecule action information;

the selection module is used for receiving a biomacromolecule model selection signal, a drug molecule model selection signal and a molecular dynamics model selection signal and calling a corresponding model from a database;

the simulation loading module is used for simulating the drug action according to the called biomacromolecule model, the drug molecule model and the molecular dynamics model to form a molecular motion process under the drug action;

the three-dimensional model module is used for establishing and displaying a three-dimensional visual model according to the molecular motion process under the action of the medicament formed by the simulation loading module;

the data extraction and analysis module is used for extracting key data in the molecular motion process under the action of the medicine and performing calculation processing;

the drug action analysis module is used for analyzing the drug action according to the result of calculation processing;

and the verification analysis module is used for inquiring related verification data according to the analyzed drug action, judging the number ratio of the drug action according with the verification data, and defining the drug action reliability according to the number ratio.

2. The pathological drug action monitoring system of claim 1, wherein: further comprising: a model management module;

the model management module is used for managing a biomacromolecule model, a medicine molecule model and a molecular dynamics model in a database, and comprises: adding a model, deleting a model and replacing a model;

the model is added, the biomacromolecule state and the drug molecule state are captured by adopting a cryoelectron microscope technology, the biomacromolecule model and the drug molecule model are constructed through three-dimensional reconstruction, the molecular motion data are monitored by adopting a molecular motion capture instrument, a molecular dynamics model is constructed, and the successfully constructed biomacromolecule model, the drug molecule model and the molecular dynamics model are added into a database.

3. The pathological drug action monitoring system of claim 1, wherein: the method for defining the action credibility of the medicine according to the number ratio comprises the following steps:

if the number ratio is greater than or equal to the first preset ratio, the reliability of the action of the medicine is defined to be high;

if the number ratio is less than the first preset ratio and greater than or equal to the second preset ratio, defining the drug action reliability as middle;

if the number ratio is smaller than the second preset ratio, the reliability of the action of the medicine is defined to be low;

and the verification analysis module is also used for inquiring the existing related research direction according to the drug action which does not accord with the verification data if the credibility of the drug action is defined to be low, and generating a corresponding research subject suggestion.

4. The pathological drug action monitoring system of claim 3, wherein: the database is also used for storing molecular motion processes under the action of the drugs formed by the simulation loading module, extraction data and calculation processing results of the data extraction and analysis module, the drug action analyzed by the drug action analysis module and the drug action reliability defined by the verification and analysis module;

the data extraction and analysis module is further used for carrying out AI prejudgment, inquiring whether a calculation processing result similar to the selected model exists in the historical calculation processing results in the database or not according to the selected biomacromolecule model, the drug molecule model and the molecular dynamics model, and if so, extracting key data extracted from the similar calculation processing result.

5. The pathological drug action monitoring method is characterized by comprising the following steps: the method comprises the following steps:

a model selection step: receiving a biomacromolecule model selection signal, a drug molecule model selection signal and a molecular dynamics model selection signal, and calling a corresponding model, wherein the drug molecule model comprises drug molecule action information;

simulation: according to the called biological macromolecule model, the medicine molecule model and the molecule dynamics model, the medicine action simulation is carried out, and a molecule movement process under the medicine action is formed;

three-dimensional visualization: establishing a three-dimensional visual model according to the molecular motion process under the action of the medicament formed by the simulation loading module, and displaying the three-dimensional visual model;

key data processing steps: extracting key data in the molecular motion process under the action of the medicine, and performing calculation processing;

analyzing the drug action: analyzing the drug action according to the result of the calculation processing;

and (3) verification and analysis steps: inquiring related verification data according to the analyzed drug action, judging the number ratio of the drug action according with the verification data, and defining the drug action reliability according to the number ratio.

6. The pathological drug action monitoring method of claim 5, wherein: the method for defining the action credibility of the medicine according to the number ratio comprises the following steps:

if the number ratio is greater than or equal to the first preset ratio, the reliability of the action of the medicine is defined to be high;

if the number ratio is less than the first preset ratio and greater than or equal to the second preset ratio, defining the drug action reliability as middle;

if the number ratio is smaller than the second preset ratio, the reliability of the action of the medicine is defined to be low;

and the step of verification analysis further comprises the step of inquiring the existing related research direction according to the drug action which does not accord with the verification data if the credibility of the drug action is defined to be low, and generating a corresponding research subject suggestion.

7. The pathological drug action monitoring method of claim 5, wherein: the key data processing step further comprises: and (4) performing AI prejudgment, inquiring whether a historical calculation processing result has a calculation processing result similar to the selected model or not according to the selected biological macromolecule model, the selected drug molecule model and the selected molecular dynamics model, and if so, extracting key data extracted from the similar calculation processing result.

Technical Field

The invention relates to the technical field of drug screening, in particular to a pathological drug action monitoring system and a pathological drug action monitoring method.

Background

The medicine is used for preventing, treating and diagnosing human diseases, purposefully regulating the physiological function of human and prescribing indications or functional indications, administration and dosage, and comprises traditional Chinese medicines, chemical medicines, biological products and the like. The medicine plays an important role in the life of people, and the treatment of various diseases is not separated from the medicine.

According to statistics, the research and development of a new medicine needs 12-15 years on average, the cost is over hundred million, the cost is huge, the development of the research and development of the new medicine is severely restricted, but with the rapid development of computers and information technologies, people begin to use computer technology to assist in developing the new medicine, the research and development cost of the new medicine is effectively reduced, and the success rate of the research and development of the new medicine is improved.

However, the current computer technology assists in developing new drugs, molecular motion under the action of drugs cannot be intuitively reflected, and the correctness of the analyzed drug action conclusion cannot be preliminarily judged, so that subsequent experiments are needed for judgment, and the judgment and analysis of researchers are not facilitated.

Disclosure of Invention

One of the objectives of the present invention is to provide a pathological drug action monitoring system to reduce the development cost, visually reflect the molecular motion under the action of drugs, determine the reliability of the analyzed drug action, and help researchers to perform the determination and analysis.

The invention provides a basic scheme I: pathological drug action monitoring system comprising: the system comprises a database, a selection module, a simulation loading module, a three-dimensional model module, a data extraction and analysis module, a drug action analysis module and a verification and analysis module;

the database is used for storing a biological macromolecule model, a drug molecule model and a biological macromolecule molecular dynamics model, wherein the drug molecule model comprises drug molecule action information;

the selection module is used for receiving a biomacromolecule model selection signal, a drug molecule model selection signal and a molecular dynamics model selection signal and calling a corresponding model from a database;

the simulation loading module is used for simulating the drug action according to the called biomacromolecule model, the drug molecule model and the molecular dynamics model to form a molecular motion process under the drug action;

the three-dimensional model module is used for establishing and displaying a three-dimensional visual model according to the molecular motion process under the action of the medicament formed by the simulation loading module;

the data extraction and analysis module is used for extracting key data in the molecular motion process under the action of the medicine and performing calculation processing;

the drug action analysis module is used for analyzing the drug action according to the result of calculation processing;

and the verification analysis module is used for inquiring related verification data according to the analyzed drug action, judging the number ratio of the drug action according with the verification data, and defining the drug action reliability according to the number ratio.

The beneficial effects of the first basic scheme are as follows: researchers select a biomacromolecule model, a drug molecule model and a molecular dynamics model through a selection module according to needs, call corresponding models from a database, perform drug action simulation through a simulation loading module according to the called biomacromolecule model, the drug molecule model and the molecular dynamics model to form a molecular motion process under the action of drugs, so that the molecular motion condition of the biomacromolecule under the action of the drugs, namely under the action of the drug molecules, can be reflected, a three-dimensional visual model is established through a three-dimensional model module and displayed, so that the researchers can directly observe, study and analyze conveniently, and can preliminarily judge whether the drugs can play a preset effect through the molecular motion process under the action of the drugs, and further judge whether to perform subsequent experimental verification or not, so that the cost of drug development is reduced, and the fundamental judgment of the molecular motion is performed, the analysis of the drug action is facilitated, and the further improvement of the drug is assisted;

the data extraction and analysis module extracts key data in the molecular motion process under the action of the medicine and performs calculation processing; the drug action analysis module analyzes the drug action according to the calculation processing result so that researchers can know the drug action in the simulation process, the verification analysis module inquires related verification data including biological theory and drug action verified by biological experiments according to the analyzed drug action, the number proportion of the drug action conforming to the verification data is judged, and the drug action reliability is defined according to the number proportion, so that the researchers can judge the reliability of the drug theory not conforming to the verification data according to the drug action reliability, and the researchers are helped to select whether to verify the drug action.

Further, the system further comprises: a model management module;

the model management module is used for managing a biomacromolecule model, a medicine molecule model and a molecular dynamics model in a database, and comprises: adding a model, deleting a model and replacing a model;

the model is added, the biomacromolecule state and the drug molecule state are captured by adopting a cryoelectron microscope technology, the biomacromolecule model and the drug molecule model are constructed through three-dimensional reconstruction, the molecular motion data are monitored by adopting a molecular motion capture instrument, a molecular dynamics model is constructed, and the successfully constructed biomacromolecule model, the drug molecule model and the molecular dynamics model are added into a database.

Has the advantages that: the model management module is used for managing the biomacromolecule model, the medicine molecule model and the molecular dynamics model in the database, so that the model in the database is convenient to update and maintain, and the model is added by adopting a refrigeration electron microscope technology, a molecular motion capture instrument and a three-dimensional reconstruction technology, so that the model can be accurately constructed.

Further, the defining the credibility of the drug action according to the number ratio comprises:

if the number ratio is greater than or equal to the first preset ratio, the reliability of the action of the medicine is defined to be high;

if the number ratio is less than the first preset ratio and greater than or equal to the second preset ratio, defining the drug action reliability as middle;

if the number ratio is smaller than the second preset ratio, the reliability of the action of the medicine is defined to be low;

and the verification analysis module is also used for inquiring the existing related research direction according to the drug action which does not accord with the verification data if the credibility of the drug action is defined to be low, and generating a corresponding research subject suggestion.

Has the advantages that: and defining the reliability according to the number ratio, dividing the reliability into high, low and medium, and if the reliability of the drug action is defined to be low, inquiring the existing related research direction according to the drug action which does not accord with the verification data, and generating a corresponding research subject suggestion, thereby assisting researchers to establish the direction of the research subject.

Further, the database is also used for storing molecular motion processes under the action of the drugs formed by the simulation loading module, extraction data and calculation processing results of the data extraction and analysis module, the drug action analyzed by the drug action analysis module and the drug action credibility defined by the verification and analysis module;

the data extraction and analysis module is further used for carrying out AI prejudgment, inquiring whether a calculation processing result similar to the selected model exists in the historical calculation processing results in the database or not according to the selected biomacromolecule model, the drug molecule model and the molecular dynamics model, and if so, extracting key data extracted from the similar calculation processing result.

Has the advantages that: the key data are extracted according to the historical data, so that effective key data can be extracted as soon as possible, the memory occupation is reduced, and the operation rate is improved.

The invention also aims to provide a pathological drug action monitoring method, which is used for reducing the development cost, visually reflecting the molecular motion under the action of the drug, judging the reliability of the analyzed drug action and helping researchers to judge and analyze.

The invention provides a second basic scheme: the pathological drug action monitoring method comprises the following steps:

a model selection step: receiving a biomacromolecule model selection signal, a drug molecule model selection signal and a molecular dynamics model selection signal, and calling a corresponding model, wherein the drug molecule model comprises drug molecule action information;

simulation: according to the called biological macromolecule model, the medicine molecule model and the molecule dynamics model, the medicine action simulation is carried out, and a molecule movement process under the medicine action is formed;

three-dimensional visualization: establishing a three-dimensional visual model according to the molecular motion process under the action of the medicament formed by the simulation loading module, and displaying the three-dimensional visual model;

key data processing steps: extracting key data in the molecular motion process under the action of the medicine, and performing calculation processing;

analyzing the drug action: analyzing the drug action according to the result of the calculation processing;

and (3) verification and analysis steps: inquiring related verification data according to the analyzed drug action, judging the number ratio of the drug action according with the verification data, and defining the drug action reliability according to the number ratio.

The second basic scheme has the beneficial effects that: researchers select a biological macromolecule model, a drug molecule model and a molecular dynamics model according to requirements, call corresponding models, according to the called biological macromolecule model, the medicine molecule model and the molecule dynamics model, the medicine action simulation is carried out to form the molecular motion process under the medicine action, thereby reflecting the medicine action, namely the molecular motion condition of the biomacromolecule under the action of the drug molecule, and establishes a three-dimensional visual model for displaying, thereby being convenient for researchers to directly observe, study and analyze, and whether the medicine can play the preset effect or not can be preliminarily judged through the molecular motion process under the action of the medicine, and whether follow-up experimental verification is carried out or not is further judged, so that the cost is reduced in the drug development, the fundamental judgment of molecular motion is carried out, the analysis of the drug action is facilitated, and the further improvement of the drug is assisted.

Extracting key data in the molecular motion process under the action of the medicine, and performing calculation processing; according to the result of the calculation processing, the drug action is analyzed so that researchers can conveniently know the drug action in the simulation process, relevant verification data including biological theory and the drug action verified through biological experiments are inquired according to the analyzed drug action, the number proportion of the drug actions conforming to the verification data is judged, and the drug action reliability is defined according to the number proportion, so that the researchers can judge the reliability of the drug theory not conforming to the verification data according to the drug action reliability, and the researchers can be helped to select whether to verify the drug action or not.

Further, the defining the credibility of the drug action according to the number ratio comprises:

if the number ratio is greater than or equal to the first preset ratio, the reliability of the action of the medicine is defined to be high;

if the number ratio is less than the first preset ratio and greater than or equal to the second preset ratio, defining the drug action reliability as middle;

if the number ratio is smaller than the second preset ratio, the reliability of the action of the medicine is defined to be low;

and the step of verification analysis further comprises the step of inquiring the existing related research direction according to the drug action which does not accord with the verification data if the credibility of the drug action is defined to be low, and generating a corresponding research subject suggestion.

Has the advantages that: and defining the reliability according to the number ratio, dividing the reliability into high, low and medium, and if the reliability of the drug action is defined to be low, inquiring the existing related research direction according to the drug action which does not accord with the verification data, and generating a corresponding research subject suggestion, thereby assisting researchers to establish the direction of the research subject.

Further, the key data processing step further includes: and (4) performing AI prejudgment, inquiring whether a historical calculation processing result has a calculation processing result similar to the selected model or not according to the selected biological macromolecule model, the selected drug molecule model and the selected molecular dynamics model, and if so, extracting key data extracted from the similar calculation processing result.

Has the advantages that: the key data are extracted according to the historical data, so that effective key data can be extracted as soon as possible, the memory occupation is reduced, and the operation rate is improved.

Drawings

FIG. 1 is a logic diagram of a pathological drug effect monitoring system according to a first embodiment of the present invention;

FIG. 2 is a flowchart of a second embodiment of the method for monitoring pathological drug action according to the present invention.

Detailed Description

The following is further detailed by way of specific embodiments:

example one

The embodiment is basically as shown in the attached figure 1: pathological drug action monitoring system comprising: the system comprises a database, a model management module, a selection module, a simulation loading module, a three-dimensional model module, a data extraction and analysis module, a drug action analysis module and a verification and analysis module;

the database adopts mySQL and is used for storing a biological macromolecule model, a drug molecule model and a biological macromolecule molecular dynamics model, wherein the drug molecule model comprises drug molecule action information, the drug molecule action basically expresses that drug molecules are combined with receptors on the biological macromolecule as ligands and can cause cell function change, the drug comprises a plurality of drug molecules, different drug molecules jointly act on the biological macromolecule to play a drug role, namely, the initial effect between the drug and the cell is an motivity, is a molecular reaction mechanism and has specificity. And the database is also used for storing the molecular motion process under the action of the medicine formed by the simulation loading module, the extraction data and the calculation processing result of the data extraction and analysis module, the medicine action analyzed by the medicine action analysis module and the medicine action reliability defined by the verification and analysis module so as to be called later.

The model management module is used for managing the biomacromolecule model, the medicine molecule model and the molecular dynamics model in the database and comprises: adding a model, deleting a model and replacing a model; the method comprises the steps of adding a model, including capturing the biomacromolecule state and the drug molecule state by adopting a cryoelectron microscope technology, constructing the biomacromolecule model and the drug molecule model through three-dimensional reconstruction, monitoring molecular motion data by adopting a molecular motion capture instrument, constructing a molecular dynamics model, namely a quantum dynamics model, and adding the successfully constructed biomacromolecule model, the drug molecule model and the molecular dynamics model into a database.

And the selection module is used for receiving the biomacromolecule model selection signal, the drug molecule model selection signal and the molecular dynamics model selection signal and calling the corresponding model from the database.

The simulation loading module is used for simulating the drug action according to the called biomacromolecule model, the drug molecule model and the molecular dynamics model to form a molecular motion process under the drug action, and specifically comprises the following steps: different drug molecules bind as ligands to different receptors on different biological macromolecules and can cause changes in cell function and thus alter molecular movement processes.

The three-dimensional model module is used for establishing and displaying a three-dimensional visual model according to the molecular motion process under the action of the medicament formed by the simulation loading module; existing three-dimensional visualization services can be employed to build three-dimensional visualization models.

The data extraction and analysis module is used for extracting key data in the molecular motion process under the action of the medicine and performing calculation processing, including calculating the binding rate of different receptors and ligands and the related index change of cells after binding; before extracting the key data, the data extraction and analysis module may be further configured to perform AI pre-judgment, query, according to the selected biomacromolecule model, the drug molecule model, and the molecular dynamics model, whether a computation processing result similar to the currently selected model exists in the historical computation processing results in the database, and if so, extract the key data extracted from the similar computation processing result, for example: the method comprises the following steps of selecting a drug molecular model A, a biological macromolecular model B and a molecular motion model C, wherein receptors a, B and C are arranged on the biological macromolecular model B; and if the historical calculation processing results comprise calculation processing results of the action of the receptor a on the drug molecule model R and the biomacromolecule model B, and the drug molecule model R is similar to the drug molecule model A, namely the receptors combined by the two drug molecules are the same, directly calling the relevant data of the receptor a on the drug molecule model A and the biomacromolecule model B for calculation processing.

And the drug action analysis module is used for analyzing the drug action according to the calculation processing result, and the drug contains multiple drug molecules, so that the drug action can also be multiple drug actions.

The verification analysis module is used for inquiring related verification data according to the analyzed drug action, wherein the verification data comprises a biological theory and a drug action verified by a biological experiment, the number of the verification data in the drug action is judged, and the drug action credibility is defined according to the number of the verification data, and the verification analysis module comprises:

if the number ratio is greater than or equal to the first preset ratio, the reliability of the action of the medicine is defined to be high;

if the number ratio is less than the first preset ratio and greater than or equal to the second preset ratio, defining the drug action reliability as middle;

if the number ratio is smaller than a second preset ratio, the reliability of the action of the medicine is defined to be low, and if the reliability of the action of the medicine is defined to be low, the existing related research directions are inquired according to the action of the medicine which does not accord with the verification data, and corresponding research subject suggestions are generated, for example: the medicine contains a plurality of medicine molecules, the medicine action analysis module analyzes ten medicine actions according to the calculation processing result, related verification data is inquired, only three medicine actions conform to the related verification data, the number proportion is 3/10, the second preset proportion is seventy percent in the embodiment, the reliability of the medicine actions is low, at the moment, the medicine actions are classified according to the medicine actions which do not conform to the related verification data and are divided into first-class medicine actions and second-class medicine actions, wherein the first-class medicine actions are medicine actions which are repellent to the existing related verification data, the second-class medicine actions are medicine actions which are not mentioned in the related verification data, the existing related research directions are inquired according to the first-class medicine actions and the second-class medicine actions respectively, and if the research directions related to a certain medicine action are pushed to researchers, if the first type of medicine is not related, firstly generating a research subject suggestion opposite to the verification data according to the action of the first type of medicine, pushing the research subject suggestion to a researcher and prompting that the pushed research subject suggestion is completely opposite to the verification data, so that the research researcher can be helped to break through inherent thinking and conduct related research, and then generating a research subject suggestion according to the action of the second type of medicine, pushing the research subject suggestion to the researcher and prompting that the pushed research subject suggestion has no related verification data, so that the research researcher can be helped to find out the unexplored subject and conduct related research.

Example two

The embodiment is basically as shown in the attached figure 2: the pathological drug action monitoring method comprises the following steps:

a model selection step: receiving a biomacromolecule model selection signal, a drug molecule model selection signal and a molecular dynamics model selection signal, and calling a corresponding model, wherein the drug molecule model comprises drug molecule action information, the basic expression of the drug molecule action is that drug molecules are combined with receptors on biomacromolecules as ligands and can cause cell function change, the drug comprises a plurality of drug molecules, different drug molecules act on the biomacromolecules together to play a drug action, namely the initial action between the drug and the cells is a cause, is a molecular reaction mechanism and has specificity; mySQL is adopted in the embodiment to store a biological macromolecule model, a drug molecule model and a biological macromolecule molecular dynamics model;

simulation: according to the called biological macromolecule model, the medicine molecule model and the molecule dynamics model, the medicine action simulation is carried out, and a molecule movement process under the medicine action is formed; the method specifically comprises the following steps: different drug molecules as ligands are combined with different receptors on different biological macromolecules and can cause the function change of cells, thereby changing the molecular motion process;

three-dimensional visualization: establishing a three-dimensional visual model according to the molecular motion process under the action of the medicament formed by the simulation loading module, and displaying the three-dimensional visual model; the three-dimensional visualization model can be established by adopting the existing Huashi three-dimensional visualization service;

key data processing steps: extracting key data in the molecular motion process under the action of the drug, and performing calculation processing, including calculating the binding rate of different receptors and ligands and the related index change of cells after binding; the embodiment also provides another key data processing step: performing AI prejudgment, inquiring whether a computation processing result similar to the selected model exists in the historical computation processing result or not according to the selected biological macromolecule model, the selected drug molecule model and the selected molecular dynamics model, if so, extracting key data extracted from the similar computation processing result, performing computation processing, and extracting the key data according to the historical data, so that effective key data can be extracted as soon as possible, the memory occupation is reduced, and the computation rate is improved, for example: the method comprises the following steps of selecting a drug molecular model A, a biological macromolecular model B and a molecular motion model C, wherein receptors a, B and C are arranged on the biological macromolecular model B; if the historical calculation processing results comprise calculation processing results of the action of the receptor a on the drug molecule model R and the biomacromolecule model B, and the drug molecule model R is similar to the drug molecule model A, namely the receptors combined by the two drug molecules are the same, directly calling the relevant data of the receptor a on the drug molecule model A and the biomacromolecule model B for calculation processing;

analyzing the drug action: analyzing the drug action according to the result of the calculation processing, wherein the drug comprises a plurality of drug molecules, so that the drug action can be a plurality of drug actions;

and (3) verification and analysis steps: inquiring related verification data according to the analyzed drug action, judging the number ratio of the pieces which accord with the verification data in the drug action, and defining the drug action reliability according to the number ratio, wherein the method comprises the following steps:

if the number ratio is greater than or equal to the first preset ratio, the reliability of the action of the medicine is defined to be high;

if the number ratio is less than the first preset ratio and greater than or equal to the second preset ratio, defining the drug action reliability as middle;

if the number ratio is smaller than the second preset ratio, the reliability of the action of the medicine is defined to be low;

the step of verification analysis further comprises the step of inquiring the existing related research direction according to the drug action which does not conform to the verification data if the credibility of the drug action is defined to be low, and generating a corresponding research subject suggestion; for example: the medicine contains a plurality of medicine molecules, the medicine action analysis module analyzes ten medicine actions according to the calculation processing result, related verification data is inquired, only three medicine actions conform to the related verification data, the number proportion is 3/10, the second preset proportion is seventy percent in the embodiment, the reliability of the medicine actions is low, at the moment, the medicine actions are classified according to the medicine actions which do not conform to the related verification data and are divided into first-class medicine actions and second-class medicine actions, wherein the first-class medicine actions are medicine actions which are repellent to the existing related verification data, the second-class medicine actions are medicine actions which are not mentioned in the related verification data, the existing related research directions are inquired according to the first-class medicine actions and the second-class medicine actions respectively, and if the research directions related to a certain medicine action are pushed to researchers, if the first type of medicine is not related, firstly generating a research subject suggestion opposite to the verification data according to the action of the first type of medicine, pushing the research subject suggestion to a researcher and prompting that the pushed research subject suggestion is completely opposite to the verification data, so that the research researcher can be helped to break through inherent thinking and conduct related research, and then generating a research subject suggestion according to the action of the second type of medicine, pushing the research subject suggestion to the researcher and prompting that the pushed research subject suggestion has no related verification data, so that the research researcher can be helped to find out the unexplored subject and conduct related research.

The foregoing is merely an example of the present invention, and common general knowledge in the field of known specific structures and characteristics is not described herein in any greater extent than that known in the art at the filing date or prior to the priority date of the application, so that those skilled in the art can now appreciate that all of the above-described techniques in this field and have the ability to apply routine experimentation before this date can be combined with one or more of the present teachings to complete and implement the present invention, and that certain typical known structures or known methods do not pose any impediments to the implementation of the present invention by those skilled in the art. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.