阅读说明：本技术 用于颅内顺应性的无创确定和/或监测的方法和设备 (Methods and apparatus for non-invasive determination and/or monitoring of intracranial compliance ) 是由 米罗斯劳·罗贝尔 于 2020-03-27 设计创作，主要内容包括：本发明涉及用于生物材料(02)的颅内顺应性的无创确定和/或监测的方法,其具有以下步骤：a)进行生物材料(02)的声谱学,所述生物材料(02)是人或动物颅骨；b)将传输的声信号与相应接收的声信号进行比较,其中确定表征生物材料(02)的n维函数和传播时间值；c)确定生物材料(02)的增大,测量生物材料(02)的长度和/或体积增大；和d)基于在步骤b)中进行的比较和在步骤c)中进行的测量来确定生物材料(02)的颅内顺应性。本发明还涉及用于生物材料(02)的颅内顺应性的无创确定和/或监测的设备。(The invention relates to a method for non-invasive determination and/or monitoring of intracranial compliance of a biological material (02), having the following steps: a) performing sonography of a biological material (02), the biological material (02) being a human or animal skull; b) comparing the transmitted acoustic signals with the corresponding received acoustic signals, wherein an n-dimensional function and a propagation time value characterizing the biological material (02) are determined; c) determining an increase in the biological material (02), measuring the increase in length and/or volume of the biological material (02); and d) determining the intracranial compliance of the biological material (02) based on the comparison made in step b) and the measurement made in step c). The invention also relates to a device for non-invasive determination and/or monitoring of intracranial compliance of a biological material (02).)

1. A method for non-invasive determination and/or monitoring of intracranial compliance of a biological material (02), comprising the steps of:

a) performing acoustic spectroscopy of the biomaterial (02), emitting a plurality of acoustic transmission signals of different frequencies and/or amplitudes into the biomaterial (02) and receiving corresponding reflected and/or transmitted acoustic reception signals of different frequencies and/or amplitudes after having passed through the biomaterial (02), and the biomaterial (02) being a human or animal skull; and

b) comparing the acoustic transmission signals with corresponding acoustic reception signals, determining an n-dimensional function and a time-of-flight value that are characteristic of the biological material (02); and

c) determining the swelling of the biological material (02), measuring the linear and/or volume swelling of the biological material (02), and

d) determining the intracranial compliance of the biological material (02) based on the comparison made in step b) and the measurement made in step c).

2. The method of claim 1, wherein the first and second light sources are selected from the group consisting of,

wherein the method further comprises the steps of:

e) determining an intracranial pressure, cerebral blood flow and/or pathological condition of the biological material (02) based on the intracranial compliance determined in step d).

3. The method according to claim 1 or 2, wherein the method further comprises the steps of:

f) displaying said determination made in step d) and/or in step e).

4. The method according to any one of claims 1 to 3, wherein the acoustic transmission signal is emitted at a first position (X1) of the biological material (02) and wherein the acoustic reception signal is received at a second position (X2) of the biological material (02), and wherein the first and second positions (X1, X2) are identical or are arranged opposite to each other.

5. The method according to any one of claims 1 to 4, wherein the determination of the sonography and/or the distension of the biological material (02) is performed substantially in the area of the left and right brain and the cerebral longitudinal fissure.

6. The method according to any one of claims 1 to 5, wherein the determination of the sonography and/or the expansion of the biomaterial (02) is made slightly above the external ear canal substantially in the direction of the frontal plane of the skull.

7. A device (01) for non-invasive determination and/or monitoring of intracranial compliance of a biological material (02) according to any of the preceding method claims,

a first apparatus (10) having a sound spectroscopy for performing the biomaterial (02), wherein the first apparatus (10) comprises a sound transmitting element (11) for transmitting a plurality of sound transmitting signals of different frequencies and/or amplitudes into the biomaterial (02) and a sound receiving element (12) for receiving a corresponding reflected and/or transmitted sound receiving signal of different frequencies and/or amplitudes after having passed through the biomaterial (02), and wherein the biomaterial (02) is a human or animal skull;

having an evaluation unit (20) for comparing the acoustic transmission signals with corresponding acoustic reception signals, wherein an n-dimensional function and a time-of-flight value can be determined as a characteristic of the biological material (02); and

having a second device (30) for determining the expansion of the biological material (02), wherein the second device (30) comprises a measuring apparatus (31) for measuring the linear expansion and/or the volume expansion of the biological material (02); and

having an analysis unit (40) for determining the intracranial compliance of the biological material (02) based on the comparison made and the measurement made.

8. The device (01) according to claim 7, wherein the analysis unit (40) is configured to determine an intracranial pressure, a cerebral blood flow and/or a pathological condition of the biological material (02) based on the determined intracranial compliance.

9. The device (01) according to claim 7 or 8, wherein it comprises an output unit for displaying said determination made by said analysis unit (40).

10. The device (01) according to any one of claims 7 to 9, wherein the sound transmitting element (11) is arranged at a first position (X1) of the biological material (02) and wherein the sound receiving element (12) is arranged at a second position (X2) of the biological material (02), and wherein the first and second positions (X1, X2) are identical or arranged opposite to each other.

11. Device (01) according to any one of claims 7 to 10, wherein the sonography and/or the determination of the distension of the biological material (02) is performed substantially in the area of the left and right brain and the cerebral longitudinal fissure.

12. The device (01) according to any one of claims 7 to 11, wherein the determination of the sonography and/or the expansion of the biomaterial (02) is made slightly above the external ear canal substantially in the direction of the frontal plane of the skull.

13. The apparatus (01) according to any one of claims 7 to 12, wherein the first device (10), the second device (30), the evaluation unit (20), the analysis unit (40) and/or the output unit (50) are provided in one assembly.

14. The device (01) according to any of claims 7 to 13, wherein the device (01) is realized to be rotatable and/or movable.