阅读说明：本技术 一种治疗痛风性关节炎的配方 (Formula for treating gouty arthritis ) 是由 何彦生 于 2021-10-12 设计创作，主要内容包括：本发明公开了一种治疗痛风性关节炎的配方,由以下重量的原料制备而成：苍术15g、秦皮10g、川牛膝20g、薏苡仁30g、丹皮12g、赤芍15g、萆薢20g、土茯苓20g、威灵仙15g、独活15g、香附15g、山慈菇15g、土鳖虫10g、地龙15g、延胡索20g。本发明根据中医传统理论,以泻浊化瘀的指导思想组方,该方通过泻浊解毒、活血化瘀、通利关节以达到改善关节功能、减轻疼痛、促进尿酸排泄、降低高尿酸症、提高生活质量的目的,在临床上取得了较好的疗效；符合中医理论又切中痛风性关节炎的病机特点,疗效确切,安全性高,对肝肾的代谢几乎没有损害。(The invention discloses a formula for treating gouty arthritis, which is prepared from the following raw materials in parts by weight: 15g of rhizoma atractylodis, 10g of cortex fraxini, 20g of radix cyathulae, 30g of semen coicis, 12g of cortex moutan, 15g of radix paeoniae rubra, 20g of rhizoma dioscoreae hypoglaucae, 20g of rhizoma smilacis glabrae, 15g of radix clematidis, 15g of radix angelicae pubescentis, 15g of rhizoma cyperi, 15g of edible tulip, 10g of ground beetle, 15g of earthworm and 20g of rhizoma corydalis. The traditional Chinese medicine composition is prepared according to the traditional Chinese medicine theory and the guiding thought of purging turbidity and removing blood stasis, achieves the purposes of improving joint function, relieving pain, promoting uric acid excretion, reducing hyperuricemia and improving life quality by purging turbidity, detoxifying, activating blood and removing blood stasis and easing joint movement, and achieves better curative effect clinically; the traditional Chinese medicine composition accords with the theory of traditional Chinese medicine and aims at the pathogenesis characteristics of gouty arthritis, has definite curative effect and high safety, and hardly has damage to the metabolism of liver and kidney.)

1. The formula for treating gouty arthritis is characterized by being prepared from the following raw materials in parts by weight: 15g of rhizoma atractylodis, 10g of cortex fraxini, 20g of radix cyathulae, 30g of semen coicis, 12g of cortex moutan, 15g of radix paeoniae rubra, 20g of rhizoma dioscoreae hypoglaucae, 20g of rhizoma smilacis glabrae, 15g of radix clematidis, 15g of radix angelicae pubescentis, 15g of rhizoma cyperi, 15g of edible tulip, 10g of ground beetle, 15g of earthworm and 20g of rhizoma corydalis.

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a formula for treating gouty arthritis.

Background

Gout (gout) is a heterogeneous disease formed by abnormal increase of blood uric acid level of a human body due to purine metabolic disorder and uric acid excretion disorder and deposition of urate crystals among tissues, and the clinical characteristics of hyperuricemia, tophus deposition, repeated attack of characteristic acute and chronic arthritis and even renal failure seriously affect the life quality of patients.

The traditional Chinese medicine considers that the innate endowment is insufficient, and the acquired preference to eating the thick taste of the ointment beam gradually damages the spleen, so that the dampness and turbidity are not dissolved for a long time until the dampness and turbidity are accumulated and the joints are unfavorable; or the dysfunction of spleen and kidney after aging is the main cause of gouty arthritis, and has a certain relationship with the causes of fatigue, diet, environment, exopathic infection and the like.

Modern medicine has the following medicines for treating acute gouty arthritis: non-steroidal anti-inflammatory drugs, colchicine, glucocorticoids, biological agents and the like. The 2012 ACR guidelines recommend that monotherapy or combination therapy be applied depending on the severity of the arthritis and the number of affected joints. When the non-steroidal anti-inflammatory drug is applied, adverse reactions such as thrombotic cardiovascular events, gastrointestinal perforation, ulcer, bleeding and the like are easily induced.

Disclosure of Invention

The invention aims to provide a formula for treating gouty arthritis, which is formed by considering that the main pathogenesis of gout is damp turbidity and stasis internal resistance, and the formula is formulated according to the guiding concept of purging turbidity and removing stasis, and achieves the aims of improving joint functions, relieving pain and improving life quality by purging turbidity, removing toxicity, promoting blood circulation and removing blood stasis and easing joint movement, thereby obtaining better curative effect clinically.

In order to solve the technical problems, the invention adopts the following technical scheme:

the invention provides a formula for treating gouty arthritis, which is characterized by being prepared from the following raw materials in parts by weight: 15g of rhizoma atractylodis, 10g of cortex fraxini, 20g of radix cyathulae, 30g of semen coicis, 12g of cortex moutan, 15g of radix paeoniae rubra, 20g of rhizoma dioscoreae hypoglaucae, 20g of rhizoma smilacis glabrae, 15g of radix clematidis, 15g of radix angelicae pubescentis, 15g of rhizoma cyperi, 15g of edible tulip, 10g of ground beetle, 15g of earthworm and 20g of rhizoma corydalis.

The taking method comprises the following steps:

1. decocting with water 1 dose 450ml daily, and orally taking 3 times, 150ml each time, and 7 days as a treatment course.

2. Making into powder, pill or capsule at a certain proportion, 3 times daily, 10g each time.

The invention has the beneficial effects that:

1. according to the traditional theory of traditional Chinese medicine, the traditional Chinese medicine is prepared according to the guiding thought of purging turbidity and removing blood stasis, and the formula achieves the purposes of improving joint function, relieving pain, promoting uric acid excretion, reducing hyperuricemia and improving life quality by purging turbidity and detoxifying, activating blood and removing blood stasis and easing joint movement, and achieves better curative effect clinically.

2. The traditional Chinese medicine composition accords with the theory of traditional Chinese medicine and aims at the pathogenesis characteristics of gouty arthritis, has definite curative effect and high safety, and hardly has damage to the metabolism of liver and kidney.

3. The formula has obvious clinical curative effect on treating acute gouty arthritis, can obviously improve the clinical effect of patients, and has great significance for tracking and treating the illness state of the patients.

The following further explains the beneficial effects of the invention by combining the effects of the main components in the invention:

rhizoma atractylodis: [ PROPERTIES AND WESTERN CHANNELS ] is pungent, bitter and warm in flavor. It enters spleen, stomach and liver meridians. [ FUNCTIONS INDICATIONS ] can eliminate dampness, invigorate the spleen, dispel wind and cold, and improve eyesight. Can be used for treating abdominal distention, diarrhea, edema, tinea pedis, paralysis 36484m, rheumatalgia, common cold due to wind-cold evil, and night blindness.

Cortex fraxini: [ PROPERTIES AND DENSITY ] is cold in nature, bitter and astringent in taste. It enters liver meridian, gallbladder meridian and large intestine meridian. [ EFFECT AND ACTION ] can clear heat, eliminate dampness, astringe, and improve eyesight. The modern pharmacological research has very good functions of promoting uric acid excretion and diuresis.

Radix cyathulae: [ PROPERTIES, WEI GUIJING ] bitter, sour and mild. It enters liver and kidney meridians. [ FUNCTIONS ] can tonify liver and kidney, strengthen tendons and bones, dispel blood stasis, dredge channels, and draw blood downward. Can be used for treating soreness of waist and knees, weakness of tendons and bones, amenorrhea, abdominal mass, and vertigo due to liver-yang.

Coix seed: [ PROPERTIES AND FLAVOUR DEFING CHANNEL ] is sweet, bland and cool. It enters spleen, stomach and lung meridians. [ FUNCTIONS INDICATION ] can invigorate spleen, eliminate dampness, relieve arthralgia, arrest diarrhea, clear heat and expel concentration. Can be used for treating edema, loempe, dysuresia, damp arthralgia, spasm, spleen deficiency, diarrhea, pulmonary abscess, and intestinal abscess; flat warts.

Cortex moutan: [ PROPERTIES AND FLAVOUR GUIDING CHANNEL ] is bitter, pungent and slightly cold. It enters heart, liver and kidney meridians. [ FUNCTIONS INDICATIONS ] can clear heat and cool blood, and promote blood circulation to remove blood stasis. Can be used for treating toxic heat, speckle, hematemesis, epistaxis, nocturnal fever, morning cool, anhidrosis, amenorrhea, dysmenorrhea, carbuncle, swelling, sore, traumatic injury, and pain.

Red peony root: [ PROPERTIES AND FLAVOUR DEFINITION ] bitter and slightly cold. It enters liver meridian. [ FUNCTIONS ] can clear heat and cool blood, remove blood stasis and relieve pain. Can be used for treating macula due to toxic heat, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Rhizoma Dioscoreae Septemlobae: [ PROPERTIES, WESTERN AND CHANNEL FENCH ] is bitter and neutral. Enters liver, stomach and bladder meridians. [ FUNCTIONS ] can dispel pathogenic wind and remove dampness. It is indicated for stubborn arthralgia due to wind-damp, pain in waist and knees, difficult urination, stranguria with turbid urine, spermatorrhea, damp-heat and sore-toxin.

Glabrous greenbrier rhizome: [ PROPERTIES AND FLAVOUR DEFINITION ] sweet, bland and mild. It enters liver and stomach meridians. [ FUNCTIONS INDICATIONS ] can remove dampness, remove toxic substance, and relieve joint pain. Can be used for treating damp-heat stranguria with turbid discharge, leukorrhagia, carbuncle swelling, scrofula, scabies, tinea, syphilis and limb spasm and arthralgia and myalgia caused by mercury poisoning.

Clematis root: [ PROPERTIES, WESTERN AND CHANNEL GUIDANGSHEN ] is pungent, salty in flavor and warm in nature. It enters bladder meridian. [ FUNCTIONS INDICATIONS ] has the functions of dispelling wind-damp and dredging the channels and collaterals; can be used for treating rheumatalgia, numbness of limbs, spasm of tendons and vessels, and difficulty in flexion and extension.

Radix angelicae pubescentis: [ PROPERTIES AND FLAVOUR GUIDING CHANNEL ] is pungent, bitter and slightly warm. It enters liver, kidney and bladder meridians. [ FUNCTIONS INDICATION ] can dispel pathogenic wind and dampness; dispel cold and alleviate pain. Can be used for treating arthralgia due to wind-cold-dampness; pain in the loins and knees; shaoyin wind-prone headache, headache and toothache.

Rhizoma cyperi: [ PROPERTIES AND WESTERPHIS ] is pungent, slightly bitter, sweet and mild. [ FUNCTIONS INDICATION ] can soothe the liver, regulate qi, regulate menstruation and relieve pain. Mainly used for treating liver qi stagnation, chest distress, hypochondriac pain, gastropathy and abdominal pain; and menoxenia and dysmenorrhea.

And (3) edible tulip: [ PROPERTIES AND DENSITY OF CHANNELS ] is sweet, slightly pungent and cool. It enters liver and spleen meridians. [ FUNCTIONS INDICATION ] can clear away heat and toxic materials, resolve phlegm and dissipate nodulation. Can be used for treating carbuncle, furuncle, scrofula, subcutaneous nodule, lymphoid tuberculosis, snake and insect bite.

Ground beetle: [ PROPERTIES, WESTERN AND CHANNEL GUIDING ] is salty and cold; has little toxicity. It enters liver meridian. [ FUNCTIONS INDICATIONS ] can break blood stasis and reunite tendons and bones. Can be used for treating fracture of tendons and bones, amenorrhea due to blood stasis, and abdominal mass.

Earthworm: [ PROPERTIES, WESTERN AND CHANNEL tropism ] is salty and cold. It enters liver, spleen and bladder meridians. [ FUNCTIONS INDICATIONS ] can clear heat, arrest convulsion, dredge collaterals, relieve asthma and induce diuresis. Can be used for treating hyperpyrexia, unconsciousness, epilepsy, convulsion, arthralgia, numbness of limbs, hemiplegia, cough and asthma due to lung heat, oliguria, edema, and hypertension.

Rhizoma corydalis: [ PROPERTIES AND FLAVOUR GUIDING CHANNEL ] is pungent, bitter and warm. It enters liver and spleen meridians. [ FUNCTIONS ] can dispel blood circulation, promote qi circulation, and relieve pain. Can be used for treating chest and hypochondrium, abdominal pain, amenorrhea, dysmenorrhea, puerperal blood stasis, traumatic injury, and swelling and pain.

Detailed Description

The technical solutions of the present invention will be described clearly and completely in the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

A formula for treating gouty arthritis is prepared from the following raw materials in parts by weight: 15g of rhizoma atractylodis, 10g of cortex fraxini, 20g of radix cyathulae, 30g of semen coicis, 12g of cortex moutan, 15g of radix paeoniae rubra, 20g of rhizoma dioscoreae hypoglaucae, 20g of rhizoma smilacis glabrae, 15g of radix clematidis, 15g of radix angelicae pubescentis, 15g of rhizoma cyperi, 15g of edible tulip, 10g of ground beetle, 15g of earthworm and 20g of rhizoma corydalis.

The compatibility of the components is characterized in that:

cortex Fraxini has effects of clearing heat, eliminating dampness and detoxicating, rhizoma Smilacis Glabrae has effects of removing toxic substance, eliminating dampness and promoting diuresis, Pseudobulbus Cremastrae Seu pleiones has effects of clearing heat, detoxicating, eliminating phlegm and resolving masses, rhizoma Dioscoreae Septemlobae has effects of removing dampness and eliminating turbid, dispelling pathogenic wind and eliminating dampness, and can be used for strengthening heat, eliminating dampness and detoxicating. Rhizoma atractylodis has the effects of eliminating dampness, strengthening spleen, expelling wind and removing cold, semen coicis has the effects of strengthening spleen, removing dampness, eliminating arthralgia, detoxifying, dissipating stagnation, and rhizoma cyperi has the effects of soothing liver, regulating spleen and stomach qi activity (invigorating spleen and stomach qi activity, stopping phlegm generation source), and has the effects of dissolving turbidity and detoxifying.

The red peony root and the root bark of the peony tree have the effects of clearing heat, cooling blood, removing toxicity and removing blood stasis, the corydalis tuber and the achyranthes root have the effects of activating blood, promoting qi circulation, removing blood stasis and relieving pain, and the ground beetle has the effects of activating blood, removing blood stasis, relieving swelling and relieving pain.

The clematis root and the pubescent angelica root can dispel wind-damp, and the earthworm can dredge collaterals and induce diuresis to enhance the effects of dispelling wind and removing dampness, dredging collaterals and relieving pain. The above components can relieve rheumatic pain of gouty arthritis.

Clinical trials applying the present invention:

the experimental personnel had 60 patients with acute gouty arthritis, and the treatment groups were: 50 men and 10 women, age 23-58.

The treatment method comprises the following steps: after continuously taking the medicine for 7 days, 1 dose of the medicine is taken every day, 450ml of the medicine is decocted with water, and the medicine is taken three times in the morning, at noon and at night.

Diagnostic criteria

The effect is shown: the joint red swelling and hot pain disappear, no abnormal reaction exists locally, the activity is normal, and the blood uric acid value is reduced to the normal level.

The method has the following advantages: the swelling of joints disappears, the pain is relieved, and the blood uric acid value is reduced but not reached the normal range.

And (4) invalidation: the symptoms of red swelling and hot pain of joints are not obviously improved, the activity is still affected, and the blood uric acid value is not reduced.

As a result: 60 treatment personnel have 28 significant effects and 29 effective effects, and the effective rate is 95%.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.