阅读说明：本技术 一种监测血液中物质浓度用的三通管路及监测系统 (Three-way pipeline and monitoring system for monitoring concentration of substances in blood ) 是由 陈治宇 郝祥仪 样渐彬 董炎 魏鸿晶 于 2021-10-12 设计创作，主要内容包括：本发明公开了一种监测血液中物质浓度用的三通管路及监测系统,三通管路包括三通连接件、探针管、体液管、检测管。三通连接件内设有一个Y形管,Y形管同一端的两个支管分别连接探针管、体液管,Y形管另一端连接检测管；检测管上预设位置设有照射管。物质浓度监测系统包括试剂助推器、微渗透管、光谱分析仪及上述的三通管路。试剂助推器连接有检测试剂管,检测试剂管另一端与探针管连接；微渗透管一端用于埋入人体血管内并采集血液,另一端与体液管连接；光谱分析仪用于检测分析血液中的物质浓度值。可以实时监测患者体内的血糖、抗生素或者麻醉药浓度,提供更加准确、具有代表性的物质浓度值。(The invention discloses a three-way pipeline for monitoring the concentration of substances in blood and a monitoring system. A Y-shaped pipe is arranged in the three-way connecting piece, two branch pipes at the same end of the Y-shaped pipe are respectively connected with the probe pipe and the body fluid pipe, and the other end of the Y-shaped pipe is connected with the detection pipe; the preset position on the detection tube is provided with an irradiation tube. The substance concentration monitoring system comprises a reagent booster, a micro-permeation tube, a spectrum analyzer and the three-way pipeline. The reagent booster is connected with a detection reagent tube, and the other end of the detection reagent tube is connected with a probe tube; one end of the micro-osmotic tube is used for embedding into a blood vessel of a human body and collecting blood, and the other end is connected with the body fluid tube; the spectrum analyzer is used for detecting and analyzing the concentration value of substances in blood. The blood sugar, antibiotic or narcotic concentration in the body of the patient can be monitored in real time, and a more accurate and representative substance concentration value is provided.)

1. A three-way pipeline for monitoring the concentration of substances in blood is characterized by comprising a three-way connecting piece (4), and a probe tube (1), a body fluid tube (2) and a detection tube (3) which are respectively connected with the three-way connecting piece (4);

a Y-shaped pipe (41) is arranged in the three-way connecting piece (4), two branch pipes at the same end of the Y-shaped pipe (41) are respectively connected with the probe pipe (1) and the body fluid pipe (2), the other end of the Y-shaped pipe (41) is connected with the detection pipe (3), and female luer connectors (11) are arranged at the other ends of the probe pipe (1) and the body fluid pipe (2);

an irradiation tube (31) is arranged at a preset position on the detection tube (3), the irradiation tube (31) is a quartz tube or a PMMA tube, a glass tube fixing block (32) is arranged outside the irradiation tube (31), and a through hole (321) is formed in the side wall of the glass tube fixing block (32).

2. The three-way tube for monitoring the concentration of substances in blood according to claim 1, wherein the inner diameters of the probe tube (1), the body fluid tube (2) and the detection tube (3) are all 30 μm to 300 μm, and the wall thickness of the tube is all 0.5mm to 2.5 mm.

3. The three-way tube for monitoring the concentration of substances in blood according to claim 1 or 2, wherein the three-way tube is made of PTFE tube or other high-strength modified plastic tube with the material bearing capacity of 3N-15N.

4. The three-way tube for monitoring the concentration of substances in blood according to claim 3, wherein the probe tube (1) and the body fluid tube (2) have lengths within the interval of 0.5m to 2.5m, and the detection tube (3) has a length within the interval of 0.5m to 1.5 m.

5. A real-time on-line monitoring system for substance concentration comprises a reagent booster (5), a micro-permeation tube (6), a spectrum analyzer and a three-way pipeline for monitoring the substance concentration in blood as claimed in claim 4;

the reagent booster (5) is connected with a detection reagent tube (51), the other end of the detection reagent tube (51) is connected with the probe tube (1) through a female luer connector (11), and the reagent booster (5) is used for loading a reagent for detecting the concentration of a substance and pushing the detection reagent into the probe tube (1);

one end of the micro-osmotic tube (6) is provided with an osmotic membrane (62), the micro-osmotic tube (6) at the other end is used for embedding into a human body blood vessel and collecting blood, the other end of the micro-osmotic tube (6) is connected with the body fluid tube (2) through a female luer connector (11), the micro-osmotic tube (6) is provided with a body fluid driver (61), and the body fluid driver (61) is used for pushing the collected blood into the body fluid tube (2);

the spectrometer is used for detecting the concentration value of an analyte by irradiating the irradiation tube (31) through the through hole (321).

6. The system for real-time online monitoring of the concentration of a substance according to claim 5, wherein the other end of the detection tube (3) is connected with a waste liquid treatment mechanism (7), and the waste liquid treatment mechanism (7) is used for treating waste liquid flowing out of the irradiation tube (31).

7. The system for real-time on-line monitoring of substance concentration according to claim 5 or 6, is used for detecting any one of blood glucose concentration, antibiotic concentration and anesthetic concentration in blood.

Technical Field

The invention relates to the technical field of blood substance concentration detection, in particular to a three-way pipeline and a monitoring system for monitoring the concentration of substances in blood.

Background

Hospitalized patients, particularly severe patients and perioperative patients, may have severe clinical consequences and affect the prognosis of patients due to rapid fluctuation of some substances in their blood caused by critical conditions and various stress reactions. At present, medical staff mostly adopt two modes of venous blood drawing and rapid fingertip peripheral blood to detect the concentration of blood sugar, antibiotics or narcotic drugs of a patient so as to timely respond to the change of the state of an illness, but the concentration of substances in a human body is a variable which changes along with time and is influenced by a plurality of factors such as mood, diet, blood sampling amount, proficiency of an operator and the like, so the concentration value of the blood substances measured at a single time has great randomness. In order to make the measured blood substance concentration value representative, medical staff needs to repeatedly take blood samples by needle puncture for patients, but the intermittent concentration measurement also causes medical pain for patients.

Disclosure of Invention

In order to solve the defects of the prior art, the invention provides a three-way pipeline and a monitoring system for monitoring the concentration of substances in blood, which can monitor the concentration of substances in a patient body in real time and provide a more accurate and representative blood substance concentration value; but also reduce the operation of frequently sampling blood for patients and relieve the pain of the patients.

In order to realize the purpose of the invention, the following scheme is adopted:

a three-way pipeline for monitoring the concentration of substances in blood comprises a three-way connecting piece, and a probe tube, a body fluid tube and a detection tube which are respectively connected with the three-way connecting piece.

A Y-shaped pipe is arranged in the three-way connecting piece, two branch pipes at the same end of the Y-shaped pipe are respectively connected with the probe pipe and the body fluid pipe, the other end of the Y-shaped pipe is connected with the detection pipe, and female luer connectors are arranged at the other ends of the probe pipe and the body fluid pipe;

the detection tube is provided with an irradiation tube at a preset position, the irradiation tube is a quartz tube or a PMMA tube, a glass tube fixing block is arranged outside the irradiation tube, and a through hole is formed in the side wall of the glass tube fixing block.

Furthermore, the inner diameters of the probe tube, the body fluid tube and the detection tube are all 30-300 mu m, and the wall thickness of the tube is 0.5-2.5 mm.

Furthermore, the three-way pipeline is made of a PTFE pipe or other high-strength modified plastic pipes with the material bearing capacity of 3N-15N.

Furthermore, the lengths of the probe tube and the body fluid tube are both within the interval of 0.5m-2.5m, and the length of the detection tube is 0.5m-1.5 m.

A real-time on-line monitoring system for substance concentration comprises a reagent booster, a micro-permeation tube, a spectrum analyzer and the three-way pipeline for monitoring the substance concentration in blood.

The reagent booster is connected with a detection reagent tube, the other end of the detection reagent tube is connected with the probe tube through a female luer connector, and the reagent booster is used for bearing a reagent for detecting the concentration of a substance and pushing the detection reagent into the probe tube;

one end of the micro-osmotic tube is provided with an osmotic membrane, the micro-osmotic tube at the one end is used for embedding into a human body blood vessel and collecting blood, the other end of the micro-osmotic tube is connected with a body fluid tube through a female luer connector, the micro-osmotic tube is provided with a body fluid driver, and the body fluid driver is used for pushing the collected blood into the body fluid tube;

the spectrum analyzer is used for irradiating the irradiation tube through the through hole to detect the concentration value of the analysis substance.

Furthermore, the other end of the detection tube is connected with a waste liquid treatment mechanism, and the waste liquid treatment mechanism is used for treating waste liquid flowing out of the irradiation tube.

Furthermore, the kit is used for detecting any one of blood sugar concentration, antibiotic concentration and narcotic concentration in blood.

The invention has the beneficial effects that:

1. the three-way pipeline is provided with a probe pipe, a body fluid pipe and a detection pipe, the probe pipe and the body fluid pipe are respectively used for collecting a substance detection reagent and blood of a patient, the reagent and the blood are mixed in the three-way connecting piece and then flow into the detection pipe for detection, the structure is simple, the use is convenient, the inner diameter of the pipe of the three-way pipeline is between 30 and 300 mu m, and a PTFE pipe or other high-strength modified plastic pipes with the bearing capacity between 3 and 15N are used;

2. the body fluid tube is connected with the micro-osmotic tube, the osmotic membrane at one end of the micro-osmotic tube is used for embedding into a blood vessel of a human body and collecting blood, and the osmotic membrane can enable small molecules such as glucose, water and the like in the blood to pass through, so that the collected blood flows into the body fluid tube under the action of the body fluid driver, compared with the intermittent blood collection detection of the concentration of a substance, the micro-osmotic tube is always embedded into the blood vessel of a patient, the concentration of the substance in the body of the patient can be monitored in real time, the frequent blood collection operation is reduced, the pain of the patient is relieved, and more accurate and representative blood sugar, antibiotic or anesthetic concentration values are provided;

3. the method utilizes the spectrum analyzer to irradiate the irradiation tube to detect the concentration value of the substance in the blood, and compared with the conventional test paper detection method, the method has the advantages that the detected blood sugar value is more accurate, and the consumed materials are less; the invention is also additionally provided with a waste liquid treatment mechanism which is used for treating the blood waste liquid flowing out of the irradiation tube and treating the medical waste liquid in time, thereby effectively reducing the risk of cross infection in a hospital.

Drawings

FIG. 1 is a plan view of a three-way pipe according to example 1;

FIG. 2 is an enlarged partial perspective view of A in FIG. 1;

FIG. 3 is a plan perspective view of the three-way connection member of embodiment 1;

FIG. 4 is a plan view of the substance concentration real-time on-line monitoring system of example 2;

FIG. 5 is a flow chart of the liquid flow in example 2.

Detailed Description

Example 1

As shown in fig. 1, the present embodiment provides a three-way pipeline for monitoring the concentration of a substance in blood, which includes a three-way connector 4, and a probe tube 1, a body fluid tube 2, and a detection tube 3 respectively connected to the three-way connector 4.

Specifically, as shown in fig. 3, a Y-shaped tube 41 is arranged in the three-way connecting piece 4, two branch tubes at the same end of the Y-shaped tube 41 are respectively connected with the probe tube 1 and the body fluid tube 2, the other end of the Y-shaped tube 41 is connected with the detection tube 3, the other ends of the probe tube 1 and the body fluid tube 2 are both provided with female luer connectors 11, and for convenience of use, the two female luer connectors 11 are different in color.

Specifically, as shown in fig. 2, an irradiation tube 31 is arranged at a preset position on the detection tube 3, the distance between the irradiation tube 31 and the three-way connecting piece 4 is 15cm-30cm, a glass tube fixing block 32 is arranged outside the irradiation tube 31, a through hole 321 is arranged on the side wall of the glass tube fixing block 32, and the irradiation tube 31 is matched with a spectrum analyzer and used for detecting the concentration of a substance.

More specifically, the probe tube 1, the body fluid tube 2 and the detection tube 3 are all 30-300 μm, the wall thickness of the tubes is 0.5-2.5 mm, the three-way pipeline is made of PTFE tubes or other high-strength modified plastic tubes with the material bearing capacity of 3-15N, the length of the probe tube 1 and the length of the body fluid tube 2 are all within the range of 0.5-2.5 m, and the length of the detection tube 3 is 0.5-1.5 m.

As one preferred embodiment, the three-way pipeline is a PTFE (Polytetrafluoroethylene) pipe made of a material with the bearing capacity of 10N, the inner diameters of the probe pipe 1, the body fluid pipe 2 and the detection pipe 3 are all 300 mu m, the wall thicknesses of the pipes are all 1.3mm, the lengths of the probe pipe 1 and the body fluid pipe 2 are all 0.59m, and the length of the detection pipe 3 is 1.2 m.

Example 2

As shown in fig. 4, the present embodiment provides a real-time online monitoring system for substance concentration, which comprises a reagent booster 5, a micro-permeation tube 6, a spectrum analyzer and the three-way pipeline for monitoring the substance concentration in blood in embodiment 1.

Specifically, the reagent booster 5 is connected to a detection reagent tube 51, the other end of the detection reagent tube 51 is connected to the probe tube 1 via a female luer 11, and the reagent booster 5 is used for loading a reagent for detecting the concentration of a substance and pushing the detection reagent into the probe tube 1.

Specifically, one end of the micro-osmotic tube 6 is provided with an osmotic membrane 62, the micro-osmotic tube 6 at the one end is used for embedding into a human blood vessel and collecting blood, the osmotic membrane 62 can enable small molecules such as glucose and water in the blood to pass through, the other end of the micro-osmotic tube 6 is connected with the body fluid tube 2 through a female luer connector 11, the micro-osmotic tube 6 is provided with a body fluid driver 61, and the body fluid driver 61 is used for pushing the collected blood into the body fluid tube 2.

Specifically, the spectrometer is used for detecting the concentration value of the analyte by irradiating the irradiation tube 31 through the through-hole 321.

More specifically, the other end of the detection tube 3 is connected to a waste liquid treatment mechanism 7, and the waste liquid treatment mechanism 7 is used for treating waste liquid flowing out from the irradiation tube 31.

More specifically, the method is used for detecting any one of blood glucose concentration, antibiotic concentration and anesthetic concentration in blood.

As shown in fig. 5, the liquid flow route of the present embodiment is: the blood passes through the osmotic membrane 62 and the micro-osmotic tube 6 in sequence and then flows into the body fluid tube 2 and the three-way connecting piece 4 under the assistance of the body fluid driver 61; the detection reagent flows into the detection reagent pipe 51, the probe pipe 1 and the three-way connecting piece 4 from the reagent booster 5 in sequence; the blood and the detection reagent flow into the detection tube 3 together after being mixed in the three-way connecting piece 4; the laser beam from the spectrometer is irradiated on the irradiation tube 31 to detect the concentration value of the substance in the blood; the waste liquid flowing out from the irradiation tube 31 continues to flow along the detection tube 3 into the waste liquid treatment mechanism 7.

The above embodiments are only for illustrating the technical ideas and features of the present invention, and are not meant to be exclusive or limiting of the present invention. It will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the scope of the invention.