阅读说明：本技术 人体自然通道肿瘤无创靶向治疗镜及其控制方法 (Noninvasive targeting therapeutic mirror for human body natural channel tumor and control method thereof ) 是由 韩俊霞 于 2020-05-06 设计创作，主要内容包括：本发明,是一种通过对人体自然通道肿瘤大面积加热的方法,杀死恶性肿瘤细胞的治疗系统。本治疗镜由视频图像采集单元、可精准测控温度的加热段组成。控制器和治疗镜通过导线与控制器相连接,控制器通过触摸屏操作,对治疗镜进行温度测控,使治疗镜的加热段杀死癌细胞达到灭活癌细胞的物理治疗目的。本发明,涉及电热传感控温技术和生物热传导原理。(The invention relates to a treatment system for killing malignant tumor cells by a method of heating a large area of a tumor in a natural channel of a human body. The therapeutic mirror consists of a video image acquisition unit and a heating section capable of accurately measuring and controlling temperature. The controller and the therapeutic mirror are connected with the controller through wires, and the controller is operated through the touch screen to measure and control the temperature of the therapeutic mirror, so that the heating section of the therapeutic mirror kills cancer cells to achieve the aim of physical therapy of inactivating the cancer cells. The present invention relates to electrothermal sensing temperature control technology and biological heat conducting principle.)

1. The noninvasive target therapy mirror of human natural channel tumor comprises:

a video image acquisition unit (11);

a heating unit (123);

a temperature measuring unit (121);

a drug injection unit (122);

a soft sleeve (1) which can enter the natural channel of the human body;

the front end of the video image acquisition unit is provided with a transparent hemispherical cover (111) and a video mirror (112);

the front end to the tail end of the soft sleeve (1) are marked on the surface of the soft sleeve (1).

2. Human natural passage tumour does not have target therapy controller of wound, includes:

a display interface with a video image acquisition unit (11) capable of monitoring in real time;

an electric cabinet and a temperature display interface which can control the temperature of the heating unit (123);

a display interface with a temperature value real-time monitoring temperature unit (121);

a display interface is provided for controlling the injection amount of the drug injection unit (122).

3. A method for controlling noninvasive targeted therapy of natural channel tumors of a human body comprises the following steps: the controller may set an optimal temperature value for the heating unit (123); operating the therapeutic mirror to enter a human body channel to be treated; observing a display interface of the controller image acquisition unit (11), recording the scale value on the external human body natural channel soft sleeve (1) when an irregular tumor body initial end (31) appears on the display interface, recording the scale value on the external human body natural channel soft sleeve (1) when the therapeutic mirror continues to enter the therapeutic mirror to an irregular tumor body tail end (32), and recording the difference of the scale values twice, namely the length of the irregular tumor body; operating the heating unit (123) at the position of the irregular tumor to be treated; the controller is operated to send an instruction to the heating unit (123) to heat the treatment part, when the temperature measuring unit (121) rises to a set temperature value, the controller can record the temperature value of the temperature measuring unit (121) at the moment, and the constant temperature value of the heating unit (123) can be ensured through the control of the controller; the natural channel tumor of the human body is treated by heating for a set time through the controller.

4. The set temperature value of claim 3, wherein: the temperature value is within the range of 45-60 ℃, according to different conditions, the temperature can be fixed at a temperature value and the affected part is heated at constant temperature, and the required temperature value can be changed in real time to heat the affected part.

5. The setup time of claim 3, wherein: the time is in the range of 45 minutes to 240 minutes.

6. The noninvasive target treatment system for the human body natural channel tumor can stimulate the organism immune recognition and kill cancer cells.

The technical field is as follows:

the invention relates to the technical field of electric heating sensing technology and automation control. The scheme can be directly applied to clinical non-invasive thermal physical inactivation of tumor lesion tissues (including benign and malignant tumor lesion tissues) in natural channels of human bodies such as a respiratory tract system, a digestive tract system, a colorectal tract system, a cervical and vaginal system and the like.

Background art:

the medical field admits that the tumor cells are heated to 40-43 ℃ and die after being heated for 20 minutes (namely the tumor cell killing threshold value); while normal tissue cells begin to die gradually (i.e., normal cell killing threshold) when heated to above 45-47 ℃ (Roemer, 1999).

The common problem faced by the existing thermotherapy methods is how to directionally deliver heat to the tumor tissue in the target area, which can effectively kill the tumor tissue without damaging the normal tissue. At present, various heat treatment methods do not have the function of measuring temperature in real time, and are far away from clinical application, and the reasons for the condition are mainly limited by the heating mode (physics of tumor heat treatment, P17 Liu Jing, physical and chemical institute of Chinese academy of sciences, 2008.5).

To solve the problem of heat-inactivating tumor tissue with temperature without damaging surrounding normal tissue, an ideal heating pattern must be achieved: heating the tumor tissue to the killing threshold temperature of the tumor tissue, namely above 40-43 ℃, and maintaining for a sufficient time required for thoroughly destroying the lesion tissue; meanwhile, normal tissues except tumor tissues are controlled to be below the threshold temperature of normal cell killing, namely 45 ℃, so that the normal tissues or organs around the tumor are prevented from being injured due to overheating (Physics of tumor thermotherapy, P4 Liu Jing, physical and chemical institute of Chinese academy, 2008.5).

The notion of absence of quantities is not scientific. Also, there is no precise control of temperature, and there is no tumor hyperthermia (leiding jiu, 2003). All hyperthermia treatments have to date to a large extent been controlled by the personal experience and experience of the physician, however, the results of experience deviations from the actual situation are often seen in medicine (tumor hyperthermia technology and clinical practice, p107. liu jia, host of the radiotherapy department, the thermotherapy laboratory in the tumor hospital, hu nan, 2009.8). Obviously, if the ideal heating mode of tumor thermotherapy can be met, the method is very important for improving the reliability of treatment accuracy.

Therefore, to meet the ideal heating pattern and really realize tumor targeted hyperthermia, the medical device must meet the following basic requirements:

1. the heat release should produce as high a temperature as possible only in the target area (i.e. the tumor site), with the remaining healthy sites being in a safe temperature range.

2. The isothermal heating is continued for a time sufficient for the treatment in order to be as disposable as possible for the heat inactivation of the tumor.

3. The tumor tissue is completely included in the temperature above 40 ℃ to ensure the integrity of the tumor tissue to be killed.

The invention content is as follows:

the invention designs a noninvasive target therapy mirror for human body natural channel tumor, which solves the technical problems that:

in order to change the current situation that tumor patients suffer great pain, high recurrence rate and high metastasis rate due to improper treatment modes (such as surgical operation, radiotherapy and chemotherapy) of tumor lesion tissues of various parts of human bodies, so that the treatment is ineffective, the invention provides a treatment mirror (system) for measuring and controlling the natural channel tumors of the human bodies accurately, non-invasively, purely-targeted and thermally and physically inactivating the natural channel tumors of the human bodies and a treatment method thereof, according to clinical needs, the temperature between the tumor cell killing threshold and the normal cell killing threshold can be accurately, real-timely, controllably and constantly provided for target tissues (namely benign and malignant tumor lesion tissues) in a natural channel of a human body, the constant temperature treatment time is sufficiently long (generally 20-40 minutes), thereby carrying out one-time and complete thermal physical inactivation on tumor lesion tissues at different positions in the cavity without damaging adjacent normal tissue cells.

In the following description, reference is made to the accompanying drawings that are not necessarily drawn to scale, but that are shown without departing from the spirit and scope of the invention. The description is not intended to limit the contents of the following examples.

The noninvasive target therapy mirror of human natural channel tumor comprises: a video image acquisition unit 11; a heating unit 123; a temperature measuring unit 121; a drug infusion unit 122; a soft sleeve 1 which can enter the natural channel of the human body;

in some embodiments of the present invention, the front end of the video image capturing unit is a transparent hemispherical cover 111 and a video mirror 112;

in some embodiments of the present invention, the soft sleeve 1 has a scale mark on the surface of the soft sleeve 1 from the front end to the end.

Human natural passage tumour does not have target therapy controller of wound, includes: a display interface with a real-time monitoring video image acquisition unit 11; an electric cabinet and a temperature display interface which can control the temperature of the heating unit 123; a display interface with a real-time monitoring temperature value of the temperature unit 121; a display interface for controlling the injection amount of the medicine injection unit 122.

A method for controlling noninvasive targeted therapy of natural channel tumors of a human body comprises the following steps: the controller may set an optimal temperature value for the heating unit 123; operating the therapeutic mirror to enter the human body channel to be treated; observing a display interface of the controller image acquisition unit 11, recording the scale value on the external human body natural channel soft sleeve 1 when the display interface has an irregular tumor body initial end 31, continuously entering a treatment mirror to an irregular tumor body tail end 32, recording the scale value on the external human body natural channel soft sleeve 1, and recording the difference of the scale values twice, namely the length of the irregular tumor body; operating the heating unit 123 at the position of the irregular tumor to be treated; the operation controller sends an instruction to the heating unit 123 to heat the treatment part, when the temperature measuring unit 121 rises to a set temperature value, the controller records the temperature value of the temperature measuring unit 121 at the moment, and the constant temperature value of the heating unit 123 can be ensured through the control of the controller; the natural channel tumor of the human body is treated by heating for a set time through the controller.

In some embodiments of the invention, the set temperature value is in a range of 45-60 ℃, and according to different conditions, the temperature value can be fixed to heat the affected part at a constant temperature, and the required temperature value can be changed in real time to heat the affected part.

In some embodiments of the invention, the set time is in the range of 45 minutes to 240 minutes.

The invention has the beneficial effects that:

the method utilizes the natural channel of the human body as the path, avoids the pain of the patient caused by the large trauma methods such as operation, excision and the like, really achieves the aims of no wound and no pain, is easy to accept by the psychology of the patient, and is beneficial to the immediate recovery of the healthy normality of the patient after the operation.

The method utilizes a lens video means, so that a doctor can directly look at an internal target area for operation through video and accurately position the position of the pathological change, thereby really realizing a pure targeted treatment method and being beneficial to improving the intuitiveness and the safety of the doctor in the inactivation operation.

The method utilizes the low-heat inactivation principle, and the heating section has three functions of ultra-high-precision heating, temperature measurement and temperature control, so that the adjacent normal tissue is not damaged, the heating inactivation time which is long enough for continuous clinical needs of the pathological tissue can be realized, and the one-time and integrity of tumor pathological tissue inactivation can be realized.

The method utilizes the low heat inactivation principle, and the inactivated tumor lesion tissue is not carbonized and gasified, so that various complications such as 'heat absorption' and the like after operation can not appear, and the method is more favorable for a human body to quickly absorb the inactivated tumor target tissue, so that the lesion tissue quickly disappears in the body.

The method still has the gene characteristics and expression of the tumor cells because the tumor lesion tissue cells inactivated by low heat are not carbonized and gasified, and in the process that a human body absorbs the inactivated tumor lesion tissue, a large amount of antigens with the gene characteristics of the tumor cells are released, so that the organism is stimulated to generate anti-tumor immunity, the method is favorable for killing the free tumor cells in the whole body and eliminating the possibility of tumor metastasis and recurrence.

The method can stimulate organism to generate anti-tumor immunity, so it has great significance for developing tumor vaccine.

The method adopts a precise, real-time, visual and controllable mode in the whole treatment process, so that the method is favorable for regulating and controlling the operation process and evaluating afterwards.

Description of the drawings:

FIG. 1: is a structure diagram of a common type therapeutic mirror;

FIG. 2: is a principle diagram for simulating the heat inactivation of irregular tumor lesion tissues or medicine heat inactivation growing in the natural channel of a human body;

FIG. 3: is a schematic component composition diagram of a temperature automatic controller of a human body natural channel tumor noninvasive target treatment mirror;

FIG. 4: is a component composition schematic diagram of a video mirror display instrument of a human body natural channel tumor noninvasive target treatment mirror;

FIG. 5: is a pathologic morphology analysis report chart of vascular wall necrosis in malignant tumor tissues after heating treatment;

FIG. 6: is a report chart for pathomorphism analysis of vascular lumen occlusion in malignant tumor tissues after heat treatment;

FIG. 7: is a report picture of the pathological morphology analysis of the extensive necrosis of malignant tumor tissues after heat treatment;

FIG. 8: is a report picture of the pathological morphology analysis of the extensive necrosis of malignant tumor tissues after heat treatment;

FIG. 9: is a report chart for the pathological morphology analysis of a large number of immune lymphocytes in malignant tumor tissues after heat treatment;

FIG. 10: is a report picture of the pathological morphology analysis of a large number of immune plasma cells in malignant tumor tissues after heat treatment.

Figure 1, insulating outer wall soft sleeve; 111. a transparent hemispherical cover; 112. a video mirror; 121. the temperature sensor is positioned at the edge of the heating section; 122. a drug injection hole; 123. a heating element; 11. a video image acquisition section; 12. a heating section; 13. a wire transmission section; 14. a handle; 15. a wire; 2. the inner wall of the natural channel of the human body; 3. irregular tumor lesion tissues growing on the inner wall; 31. the beginning of the lesion tissue; 32. a terminal end of a diseased tissue; 4. a natural passage port of a human body.

The specific implementation mode is as follows:

the therapeutic mirror is composed of three connected functional sections (as shown in figure 1), namely a front end 11, a middle end 12 and a rear end 13, and is regulated and controlled by a set of video acquisition and automatic temperature control device. The front end 11 is a video image acquisition section and comprises a transparent hemispherical cover 111 and a video mirror 112; the middle end 12 is a heating section capable of accurately measuring and controlling temperature, and comprises an ultra-high sensitivity (capable of sensing 0.1 ℃ in 0.1 second) micro temperature sensor 121, a medicine injection hole 122 and a heating element 123 which are positioned at the inner edge of the heating section, and the manufacturing materials can be flexible insulating heat conductors such as medical soft silica gel and the like according to the treatment part and clinical requirements; the rear end 13, which is a wire transmission section, includes a handle 14 and a plurality of wires 15. Considering the difference of the internal diameters and the contraction and expansion degrees of intestines and cavities at different parts of a human body and the difference of the sizes of pathological tissues, the middle-end heating section 12 can be designed into a medical-grade insulating outer-wall soft sleeve 1 with different sizes, such as thickness, thinness, length and length along with the whole therapeutic mirror, and millimeter-grade length units are engraved on the surface of the outer wall of the sleeve. The temperature sensor and the heating element in the front-end image acquisition part 11 and the middle-end heating part 12 in the treatment mirror are connected by a wire, form an integral treatment mirror body with a medical insulation outer wall soft sleeve and a handle, are connected with a control device by the wire, and are manually or automatically regulated and controlled by a touch control screen to form a video acquisition and temperature control treatment mirror system.

As shown in fig. 1, in the middle-end heating section 12, the value of the temperature sensor 121 at the edge is set, the alarm value is preset to be 44 ℃ (the temperature is between the tumor cell and the normal cell killing threshold), after the central heating element 123 is electrified and heated, the edge of the heating section also starts to be heated after a short time according to the heat conduction principle of the heat conductor material, when the edge temperature rises to 44 ℃ and simultaneously triggers the alarm of the edge temperature sensor 121, the measurement and control device sends an automatic (or manual) "stop continuing heating" instruction to the central heating element 123 through the touch screen, so that the whole heating section is in a constant temperature state with the edge temperature of 44 ℃ (± 0.1 ℃) for 20-40 minutes. The method can provide accurate, real-time, controllable and constant temperature and last for a long enough time, can inactivate the tumor lesion tissues at one time, and greatly improve the controllability, flexibility and safety of clinical operation and the effectiveness of treatment. The whole heating section has three functions of heating, temperature measurement and temperature control,

in addition, according to clinical requirements, the required medicine can be injected into the lesion part through the medicine injection hole 122 when necessary, so that the purpose of purely targeting medicine and thermal physical inactivation of target tissues (namely lesion tissues) is achieved, and the curative effect is improved.

Fig. 2 shows the principle of the thermal physical inactivation of the lesion tissue by the above-described operation. The inner wall 2 of the natural passage (such as intestine and cavity) of the human body, namely the shadow part is any irregular tumor lesion tissue 3 simulating the growth of the inner wall of the natural passage of the human body; if the length of the video image acquisition section 3 is 2 cm and the length of the lesion tissue 2 is 5 cm, a treatment mirror with the length of the heating section 12 being 5 cm and suitable for the diameter of the natural channel of the lesion tissue is selected; the treatment mirror enters the end port 4 from the natural channel of the human body and extends into the position of the lesion tissue 3 along the inner wall 2 of the natural channel (such as intestine and cavity) of the human body; assuming that when the top end of the video capturing section 11 contacts the starting end 31 of the lesion tissue and the length unit of the surface of the scope at the entrance end of the observation channel has been extended to assume 50 cm, then the scope is extended to 7 cm (i.e. the length of the "starting end 31" and the "end 32"), i.e. the total length of the scope extended from the entrance of the observation channel is 57 cm, then the two ends of the heating section "12" having a length of 5 cm are respectively placed at the position between the starting end 31 and the end 32 of the lesion tissue, so that the whole heating section 12 is precisely matched with the position of the lesion tissue 3, thereby achieving precise targeting. Next, the operation can be performed according to the working principle of "fig. 1", and the lesion tissue is thermally inactivated once or is treated by injecting medicine at the same time.

The heating element 123 is a core unit for performing tumor inactivation, so that precise temperature control is critical, and the requirement on a heating power supply is high. The voltage value of the stable direct current power supply is required to be within a safe voltage range of 36V. And a 24V direct current switch voltage-stabilized power supply is selected to ensure the safety and reliability of the power supply.

Fig. 3 shows an automatic temperature controller:

the temperature control device is composed of a digital temperature display unit, a heating temperature control unit, a preset temperature unit and the like, wherein the digital temperature display unit is composed of real-time temperature display and preset temperature display.

The heating temperature control is to connect the heating power source and the heating element together, compare the feedback temperature value input by the temperature sensor 121 of the heating element 123 with the preset temperature feed value, and control the increase and decrease of the electric quantity of the heating element 123 by the difference value, and control and adjust the temperature of the heating element to be equal to the preset temperature. The comparison is carried out by a precise temperature sensor and a sensitive comparator. When the sensing temperature is higher than the preset temperature by 0.1 ℃, the real-time temperature starts to be adjusted downwards, and when the sensing temperature is higher than the preset temperature by 0.1 ℃, the real-time temperature starts to be adjusted upwards, so that the temperature of the heating element is always in the range of the preset temperature value +/-0.1 ℃ to highly kill the tumor at the fixed temperature, and the healthy organism can not be damaged.

The real-time heating temperature value is simultaneously transmitted to the real-time temperature display unit for displaying.

The preset temperature is output to the heating temperature control unit and is also output to the preset temperature display unit for displaying.

Fig. 4 shows a video mirror display:

through the gradual approach of the video mirror in the natural channel of the human body, the specific part of the tumor lesion tissue can be found on the screen of the video mirror display instrument in an intuitive mode of video images, and meanwhile, the heating section is accurately positioned at the lesion position, so that the purpose of accurate targeting is achieved. In the video image capturing section 11 in fig. 3, the video signal captured by the camera is output to the video mirror display in fig. 4, and the video image completely shows the operation process of the treatment.

The above is a complete pass through of the implementation, processing, monitoring, detection of the embodiments.

The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.