阅读说明：本技术 一种可用于治疗肿瘤的电场装置 (Electric field device for treating tumor ) 是由 孙岚 刘宣力 齐晓龙 于来强 杨定华 刘春华 于 2021-08-26 设计创作，主要内容包括：本发明提出了一种可用于治疗肿瘤的电场装置。所述电场装置包括波形发生装置、放大电路组、交替控制电路和输出电极组；所述波形发生装置与所述放大电路组电连接；所述放大电路组与所述交替控制电路电连接；所述交替控制电路与所述输出电极组进行电连接。所述波形发生装置包括第一波形发生电路组和第二波形发生电路组。所述第一波形发生电路组包括第一正弦波发生装置和第二正弦波发生装置；所述第二波形发生电路组包括第一方波发生装置和第二方波发生装置。(The invention provides an electric field device for treating tumors. The electric field device comprises a waveform generating device, an amplifying circuit group, an alternating control circuit and an output electrode group; the waveform generating device is electrically connected with the amplifying circuit group; the amplification circuit group is electrically connected with the alternating control circuit; the alternating control circuit is electrically connected with the output electrode group. The waveform generating apparatus includes a first waveform generating circuit group and a second waveform generating circuit group. The first waveform generation circuit group comprises a first sine wave generation device and a second sine wave generation device; the second waveform generation circuit group includes a first square wave generation device and a second square wave generation device.)

1. An electric field device for treating tumor, which is characterized in that the electric field device comprises a waveform generating device, an amplifying circuit group, an alternating control circuit and an output electrode group; the waveform generating device is electrically connected with the amplifying circuit group; the amplification circuit group is electrically connected with the alternating control circuit; the alternating control circuit is electrically connected with the output electrode group.

2. The electric field device according to claim 1, wherein the waveform generating means comprises a first waveform generating circuit group and a second waveform generating circuit group.

3. The electric field device according to claim 2, wherein the first waveform generation circuit group includes a first sine wave generation means and a second sine wave generation means; the second waveform generation circuit group includes a first square wave generation device and a second square wave generation device.

4. The electric field device of claim 2, wherein the alternate control circuit comprises a first alternate control circuit and a second alternate control circuit; the first alternating control circuit is used for performing alternating control on waveform signals on the first waveform generation circuit group; and the second alternating control circuit is used for performing waveform signal alternating control on the second waveform generation circuit group.

5. The electric field device according to claim 3, wherein the group of amplifying circuits includes a first amplifying circuit, a second amplifying circuit, a third amplifying circuit, and a fourth amplifying circuit; the first amplifying circuit is electrically connected with the first sine wave generating device; the second amplifying circuit is electrically connected with the second sine wave generating device; the third amplifying circuit is electrically connected with the first square wave generating device; the fourth amplifying circuit is electrically connected with the fourth wave generating device; the amplified signal output ends of the first, second, third and fourth amplification circuits are the signal ends of the amplification circuit group electrically connected with the alternating control circuit.

6. An electric field arrangement according to claim 3, wherein the set of output electrodes comprises a first set of output electrodes, a second set of output electrodes, a third set of output electrodes and a fourth set of output electrodes; the first output electrode group is used for outputting the waveform signal generated by the first sine wave generating device; the second output electrode group is used for outputting the waveform signal generated by the second sine wave generating device; the third output electrode group is used for outputting the waveform signal generated by the first square wave generating device; and the fourth output electrode group is used for outputting the waveform signal generated by the second square wave generating device.

7. The electric field device according to claim 2, wherein when the first waveform generating circuit group is used to generate the alternating electric field signal, the alternating electric field output process comprises:

step 1, controlling the first waveform generation circuit group to output a first electric signal for 1.2 hours according to a first sensitive frequency and a first electric field intensity;

step 2, adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group 30 minutes after the first electric signal output is finished, and outputting the second electric signal for 8 hours according to the second sensitive frequency and the second electric field intensity;

step 3, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group after the second electric signal output is finished, and outputting a third electric signal for 6 hours according to a third sensitive frequency and a third electric field intensity;

and 4, adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group after 1 hour after the third electric signal is output, and outputting the fourth electric signal for 2 hours according to the fourth sensitive frequency and the fourth electric field intensity.

8. The electric field device of claim 7, wherein the first sensitive frequency is 20 KHz-40 KHz, the first electric field strength is 0.3V/cm-0.48V/cm;

the second sensitive frequency is 450 KHz-600 KHz, and the second electric field intensity is 1.3V/cm-1.7V/cm;

the third sensitive frequency is 550 KHz-620 KHz, and the third electric field intensity is 1.6V/cm-2.1V/cm;

the fourth sensitive frequency is 350 KHz-460 KHz, and the fourth electric field intensity is 0.8V/cm-1.2V/cm.

9. The electric field device according to claim 2, wherein when the alternating electric field signal is generated using the second waveform generating circuit group, the alternating electric field output process comprises:

the first step, controlling the second waveform generating circuit group to output a first electric signal for 1 hour according to a first-stage sensitive frequency and a first-stage electric field intensity;

secondly, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group after the first electric signal output is finished, and outputting the second electric signal for 6 hours according to the second-level sensitive frequency and the second-level electric field intensity;

thirdly, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group after the second electric signal output is finished, and outputting the third electric signal for 4 hours according to the third sensitive frequency and the third electric field intensity;

fourthly, adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group 30 minutes after the third electric signal is output, and outputting the fourth electric signal for 3 hours according to the fourth-level sensitive frequency and the fourth-level electric field intensity;

and fifthly, adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group 40 minutes after the fourth electric signal is output, and outputting the fifth electric signal for 3.2 hours according to the fifth sensitive frequency and the fifth electric field intensity.

10. The electric field device of claim 9, wherein the primary sensitive frequency is 25 KHz-45 KHz, and the primary electric field strength is 0.26V/cm-0.45V/cm;

the secondary sensitive frequency is 550 KHz-600 KHz, and the secondary electric field intensity is 1.7V/cm-2.5V/cm;

the three-level sensitive frequency is 580 KHz-650 KHz, and the three-level electric field intensity is 1.9V/cm-2.7V/cm;

the four-stage sensitive frequency is 480 KHz-550 KHz, and the four-stage electric field intensity is 1.4V/cm-2.1V/cm

The five-level sensitive frequency is 330 KHz-420 KHz, and the electric field intensity of the five-level sensitive frequency is 0.6V/cm-0.9V/cm.

Technical Field

The invention provides an electric field device for treating tumors, belonging to the technical field of medical biology.

Background

When malignant tumor enters the development stage, the tumor cells are in a state of rapid growth, and the number and the time are in an exponential relationship. The basic principle of the current electric field therapy for treating tumors is established on the basis that the electric field has a positive obstacle destructive effect on the mitosis of tumor cells, and the electric field generated by electric signals in a certain frequency range is used for inhibiting the rapid growth of the tumor cells of a patient so as to achieve the treatment effect. However, in the treatment process, it is found that the electric fields generated by the electric signals with different frequencies inhibit the rapid growth of tumor cells of a plurality of patients, and the inhibition effects are different from each other, and the existing electric field device for tumor treatment often only adopts the electric field signals with the frequency and the field intensity within a range aiming at the treatment of one day in the treatment process of one patient, so that the tumor cells of the patient are not sensitive to the electric field generated by the electric signals within a certain fixed range, and the inhibition effect cannot meet the treatment requirement.

Disclosure of Invention

The invention provides an electric field device for treating tumors, which is used for solving the problem that the existing electric field device for treating tumors has poor tumor cell inhibition effect:

an electric field device for treating tumors, which comprises a waveform generating device, an amplifying circuit group, an alternating control circuit and an output electrode group; the waveform generating device is electrically connected with the amplifying circuit group; the amplification circuit group is electrically connected with the alternating control circuit; the alternating control circuit is electrically connected with the output electrode group.

Further, the waveform generation device includes a first waveform generation circuit group and a second waveform generation circuit group.

Further, the first waveform generation circuit group includes a first sine wave generation device and a second sine wave generation device; the second waveform generation circuit group includes a first square wave generation device and a second square wave generation device.

Further, the alternate control circuit includes a first alternate control circuit and a second alternate control circuit; the first alternating control circuit is used for performing alternating control on waveform signals on the first waveform generation circuit group; and the second alternating control circuit is used for performing waveform signal alternating control on the second waveform generation circuit group.

Further, the amplification circuit group includes a first amplification circuit, a second amplification circuit, a third amplification circuit, and a fourth amplification circuit; the first amplifying circuit is electrically connected with the first sine wave generating device; the second amplifying circuit is electrically connected with the second sine wave generating device; the third amplifying circuit is electrically connected with the first square wave generating device; the fourth amplifying circuit is electrically connected with the fourth wave generating device; the amplified signal output ends of the first, second, third and fourth amplification circuits are the signal ends of the amplification circuit group electrically connected with the alternating control circuit.

Further, the output electrode groups comprise a first output electrode group, a second output electrode group, a third output electrode group and a fourth output electrode group; the first output electrode group is used for outputting the waveform signal generated by the first sine wave generating device; the second output electrode group is used for outputting the waveform signal generated by the second sine wave generating device; the third output electrode group is used for outputting the waveform signal generated by the first square wave generating device; and the fourth output electrode group is used for outputting the waveform signal generated by the second square wave generating device.

Further, when the alternating electric field signal is generated using the first waveform generating circuit group, the alternating electric field output process includes:

step 1, controlling the first waveform generation circuit group to output a first electric signal for 1.2 hours according to a first sensitive frequency and a first electric field intensity;

step 2, adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group 30 minutes after the first electric signal output is finished, and outputting the second electric signal for 8 hours according to the second sensitive frequency and the second electric field intensity;

step 3, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group after the second electric signal output is finished, and outputting a third electric signal for 6 hours according to a third sensitive frequency and a third electric field intensity;

and 4, adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group after 1 hour after the third electric signal is output, and outputting the fourth electric signal for 2 hours according to the fourth sensitive frequency and the fourth electric field intensity.

Furthermore, the first sensitive frequency is 20 KHz-40 KHz, and the first electric field intensity is 0.3V/cm-0.48V/cm; preferably: the first sensitive frequency is 30KHz, and the first electric field intensity is 0.45V/cm;

the second sensitive frequency is 450 KHz-600 KHz, and the second electric field intensity is 1.3V/cm-1.7V/cm; preferably: the second sensitive frequency is 530KHz, and the second electric field intensity is 1.5V/cm;

the third sensitive frequency is 550 KHz-620 KHz, and the third electric field intensity is 1.6V/cm-2.1V/cm; preferably: the third sensitive frequency is 585KHz, and the third electric field intensity is 1.9V/cm;

the fourth sensitive frequency is 350 KHz-460 KHz, and the fourth electric field intensity is 0.8V/cm-1.2V/cm; preferably: the third sensitive frequency is 390KHz, and the third electric field intensity is 1.1V/cm.

Further, when the alternating electric field signal is generated using the second waveform generating circuit group, the alternating electric field output process includes:

the first step, controlling the second waveform generating circuit group to output a first electric signal for 1 hour according to a first-stage sensitive frequency and a first-stage electric field intensity;

secondly, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group after the first electric signal output is finished, and outputting the second electric signal for 6 hours according to the second-level sensitive frequency and the second-level electric field intensity;

thirdly, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group after the second electric signal output is finished, and outputting the third electric signal for 4 hours according to the third sensitive frequency and the third electric field intensity;

fourthly, adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group 30 minutes after the third electric signal is output, and outputting the fourth electric signal for 3 hours according to the fourth-level sensitive frequency and the fourth-level electric field intensity;

and fifthly, adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group 40 minutes after the fourth electric signal is output, and outputting the fifth electric signal for 3.2 hours according to the fifth sensitive frequency and the fifth electric field intensity.

Furthermore, the first-stage sensitive frequency is 25 KHz-45 KHz, and the first-stage electric field intensity is 0.26V/cm-0.45V/cm; preferably: the first-stage sensitive frequency is 35KHz, and the first-stage electric field intensity is 0.38V/cm;

the secondary sensitive frequency is 550 KHz-600 KHz, and the secondary electric field intensity is 1.7V/cm-2.5V/cm; preferably: the secondary sensitive frequency is 570KHz, and the secondary electric field intensity is 2.1V/cm;

the three-level sensitive frequency is 580 KHz-650 KHz, and the three-level electric field intensity is 1.9V/cm-2.7V/cm; preferably: the three-level sensitive frequency is 610KHz, and the three-level electric field intensity is 2.5V/cm;

the four-stage sensitive frequency is 480 KHz-550 KHz, and the four-stage electric field intensity is 1.4V/cm-2.1V/cm; preferably: the four-stage sensitive frequency is 510KHz, and the four-stage electric field intensity is 1.7V/cm;

the five-level sensitive frequency is 330 KHz-420 KHz, and the electric field intensity of the five-level sensitive frequency is 0.6V/cm-0.9V/cm; preferably: the five-level sensitive frequency is 370KHz, and the electric field intensity of the five-level is 0.6V/cm.

The invention has the beneficial effects that:

the electric field device for treating the tumor provided by the invention can realize the electric signal output of different types of alternating electric fields on the same machine equipment by forming the alternating electric fields with two waveforms, effectively improves the stimulation schemes aiming at different types of tumor cells, and can meet the use of various electric signal stimulation schemes without frequently replacing equipment. Simultaneously, can effectively improve the degree of stimulation and the stimulation variation variety to tumor cell through setting up of alternating electric field output frequency and electric field strength, and then reduce tumor cell and produce the condition emergence that tolerates and lead to the stimulation effect to reduce to the signal of telecommunication frequency and the electric field strength in the same scope at one stage stimulation in-process, and then effectively improve tumor cell's stimulation effect.

Drawings

FIG. 1 is a schematic view of an electric field apparatus according to the present invention;

FIG. 2 is a first flowchart of the alternating electric field output according to the present invention;

FIG. 3 is a second flow chart of the output of the alternating electric field according to the present invention.

Detailed Description

The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.

The embodiment of the invention provides an electric field device for treating tumors, which comprises a waveform generating device, an amplifying circuit group, an alternating control circuit and an output electrode group, wherein the amplifying circuit group is connected with the output electrode group; the waveform generating device is electrically connected with the amplifying circuit group; the amplification circuit group is electrically connected with the alternating control circuit; the alternating control circuit is electrically connected with the output electrode group.

Wherein the waveform generation device comprises a first waveform generation circuit group and a second waveform generation circuit group. The first waveform generation circuit group comprises a first sine wave generation device and a second sine wave generation device; the second waveform generation circuit group includes a first square wave generation device and a second square wave generation device.

The alternating control circuit comprises a first alternating control circuit and a second alternating control circuit; the first alternating control circuit is used for performing alternating control on waveform signals on the first waveform generation circuit group; and the second alternating control circuit is used for performing waveform signal alternating control on the second waveform generation circuit group.

The amplification circuit group comprises a first amplification circuit, a second amplification circuit, a third amplification circuit and a fourth amplification circuit; the first amplifying circuit is electrically connected with the first sine wave generating device; the second amplifying circuit is electrically connected with the second sine wave generating device; the third amplifying circuit is electrically connected with the first square wave generating device; the fourth amplifying circuit is electrically connected with the fourth wave generating device; the amplified signal output ends of the first, second, third and fourth amplification circuits are the signal ends of the amplification circuit group electrically connected with the alternating control circuit.

Wherein the output electrode groups comprise a first output electrode group, a second output electrode group, a third output electrode group and a fourth output electrode group; the first output electrode group is used for outputting the waveform signal generated by the first sine wave generating device; the second output electrode group is used for outputting the waveform signal generated by the second sine wave generating device; the third output electrode group is used for outputting the waveform signal generated by the first square wave generating device; and the fourth output electrode group is used for outputting the waveform signal generated by the second square wave generating device.

The working principle of the technical scheme is as follows: the first waveform generation circuit group is used for generating two sine waves, the second waveform generation circuit group is used for generating two square waves, the first waveform generation circuit group and the second waveform generation circuit group respectively amplify signals through corresponding amplifying circuits in the amplifying circuit group, and the first waveform generation circuit group and the second waveform generation circuit group respectively carry out corresponding clock control through a first alternate control circuit and a second alternate control circuit through the amplified signals to form two alternating electric fields with different waveforms, namely a sine wave alternating electric field and a square wave alternating electric field. And finally, the two alternating electric fields with different waveforms are subjected to electric signal output through corresponding electrodes in the output electrode group. The tumor cells can then be stimulated via the output electrodes.

The effect of the above technical scheme is as follows: the embodiment provides an electric field device for treating tumors, which can realize the output of electric signals of different types of alternating electric fields on the same machine equipment by forming alternating electric fields with two waveforms, effectively improve stimulation schemes aiming at different types of tumor cells, and can meet the use of multiple electric signal stimulation schemes without frequently replacing equipment. Simultaneously, can effectively improve the degree of stimulation and the stimulation variation variety to tumor cell through setting up of alternating electric field output frequency and electric field strength, and then reduce tumor cell and produce the condition emergence that tolerates and lead to the stimulation effect to reduce to the signal of telecommunication frequency and the electric field strength in the same scope at one stage stimulation in-process, and then effectively improve tumor cell's stimulation effect.

In one embodiment of the present invention, as shown in fig. 2, when the alternating electric field signal is generated using the first waveform generating circuit group, the alternating electric field output process includes:

step 1, controlling the first waveform generation circuit group to output a first electric signal for 1.2 hours according to a first sensitive frequency and a first electric field intensity;

step 2, adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group 30 minutes after the first electric signal output is finished, and outputting the second electric signal for 8 hours according to the second sensitive frequency and the second electric field intensity;

step 3, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group after the second electric signal output is finished, and outputting a third electric signal for 6 hours according to a third sensitive frequency and a third electric field intensity;

and 4, adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group after 1 hour after the third electric signal is output, and outputting the fourth electric signal for 2 hours according to the fourth sensitive frequency and the fourth electric field intensity.

Wherein, the first sensitive frequency is 20 KHz-40 KHz, and the first electric field intensity is 0.3V/cm-0.48V/cm; preferably: the first sensitive frequency is 30KHz, and the first electric field intensity is 0.45V/cm;

the second sensitive frequency is 450 KHz-600 KHz, and the second electric field intensity is 1.3V/cm-1.7V/cm; preferably: the second sensitive frequency is 530KHz, and the second electric field intensity is 1.5V/cm;

the third sensitive frequency is 550 KHz-620 KHz, and the third electric field intensity is 1.6V/cm-2.1V/cm; preferably: the third sensitive frequency is 585KHz, and the third electric field intensity is 1.9V/cm;

the fourth sensitive frequency is 350 KHz-460 KHz, and the fourth electric field intensity is 0.8V/cm-1.2V/cm; preferably: the third sensitive frequency is 390KHz, and the third electric field intensity is 1.1V/cm.

When the frequency and the electric field intensity are determined, the frequency adjusting amplitude is 3-5Khz each time, and the electric field intensity adjusting amplitude is 0.1V/cm each time;

the working principle of the technical scheme is as follows: when the sine wave generated by the first waveform generating circuit group is used for outputting alternating electric field signals and stimulating tumor cells, one scheme of the alternating electric field output is as follows: firstly, controlling the first waveform generation circuit group to output a first electric signal for 1.2 hours according to a first sensitive frequency and a first electric field intensity; then, adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group 30 minutes after the first electric signal output is finished, and outputting the second electric signal for 8 hours according to the second sensitive frequency and the second electric field intensity; immediately adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group after the second electric signal output is finished, and outputting a third electric signal for 6 hours according to a third sensitive frequency and a third electric field intensity; and finally, adjusting the sensitive frequency and the alternating electric field intensity output by the first waveform generating circuit group 1 hour after the third electric signal is output, and outputting the fourth electric signal for 2 hours according to the fourth sensitive frequency and the fourth electric field intensity.

The effect of the above technical scheme is as follows: the stimulation degree and the stimulation variation diversity of the tumor cells can be effectively improved through the arrangement of the output frequency of the alternating electric field and the electric field intensity, so that the condition that the stimulation effect is reduced due to the fact that the tumor cells are resistant to the electric signal frequency and the electric field intensity in the same range in the one-stage stimulation process is reduced, and the stimulation effect of the tumor cells is effectively improved.

Meanwhile, the tumor cell sample is stimulated through the mode and the specific range of the frequency and the electric field intensity, the range of the electric field device for treating the tumor condition can be enlarged, the obvious inhibition effect is basically realized for the common tumor cell condition in the frequency and electric field intensity setting range, in addition, the time length of the good stimulation effect of the tumor cell can be effectively prolonged due to the replacement type alternate stimulation of the four times of frequency and the electric field intensity and the combination of the time length coordination of the stimulation in each stage, the condition that the stimulation effect is reduced due to the tolerance generated by the frequency of an electric signal and the electric field intensity in the same range is effectively prevented, and the tumor cell stimulation effect can be greatly improved through the optimized value in most cases. On the other hand, when a stimulation pathology experiment is carried out on a tumor cell sample of an individual patient, the frequency and the specific electric field strength value with a good stimulation effect on the tumor cell sample of the patient can be quickly found through the range of the frequency and the range of the electric field strength, the acquisition time of the frequency and the specific electric field strength value corresponding to the good stimulation effect of the tumor cell is effectively shortened, the acquisition effect of the frequency and the specific electric field strength value corresponding to the good stimulation effect of the tumor cell is improved, and the patient can enter a specific treatment stage as soon as possible.

In an embodiment of the present invention, as shown in fig. 3, when the alternating electric field signal is generated using the second waveform generating circuit group, the alternating electric field output process includes:

the first step, controlling the second waveform generating circuit group to output a first electric signal for 1 hour according to a first-stage sensitive frequency and a first-stage electric field intensity;

secondly, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group after the first electric signal output is finished, and outputting the second electric signal for 6 hours according to the second-level sensitive frequency and the second-level electric field intensity;

thirdly, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group after the second electric signal output is finished, and outputting the third electric signal for 4 hours according to the third sensitive frequency and the third electric field intensity;

fourthly, adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group 30 minutes after the third electric signal is output, and outputting the fourth electric signal for 3 hours according to the fourth-level sensitive frequency and the fourth-level electric field intensity;

and fifthly, adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group 40 minutes after the fourth electric signal is output, and outputting the fifth electric signal for 3.2 hours according to the fifth sensitive frequency and the fifth electric field intensity.

Wherein, the first-stage sensitive frequency is 25 KHz-45 KHz, and the first-stage electric field intensity is 0.26V/cm-0.45V/cm; preferably: the first-stage sensitive frequency is 35KHz, and the first-stage electric field intensity is 0.38V/cm;

the secondary sensitive frequency is 550 KHz-600 KHz, and the secondary electric field intensity is 1.7V/cm-2.5V/cm; preferably: the secondary sensitive frequency is 570KHz, and the secondary electric field intensity is 2.1V/cm;

the three-level sensitive frequency is 580 KHz-650 KHz, and the three-level electric field intensity is 1.9V/cm-2.7V/cm; preferably: the three-level sensitive frequency is 610KHz, and the three-level electric field intensity is 2.5V/cm;

the four-stage sensitive frequency is 480 KHz-550 KHz, and the four-stage electric field intensity is 1.4V/cm-2.1V/cm; preferably: the four-stage sensitive frequency is 510KHz, and the four-stage electric field intensity is 1.7V/cm;

the five-level sensitive frequency is 330 KHz-420 KHz, and the electric field intensity of the five-level sensitive frequency is 0.6V/cm-0.9V/cm; preferably: the five-level sensitive frequency is 370KHz, and the electric field intensity of the five-level is 0.6V/cm.

When the frequency and the electric field intensity are determined, the frequency adjusting amplitude is 3-5Khz each time, and the electric field intensity adjusting amplitude is 0.1V/cm each time;

the working principle of the technical scheme is as follows: when the square wave generated by the second waveform generating circuit group is used for outputting alternating electric field signals and stimulating tumor cells, one scheme of the alternating electric field output is as follows: firstly, controlling the second waveform generation circuit group to output a first electric signal for 1 hour according to a first-stage sensitive frequency and a first-stage electric field intensity; then, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group after the first electric signal output is finished, and outputting the second electric signal for 6 hours according to the second-level sensitive frequency and the second-level electric field intensity; then, immediately adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group after the second electric signal output is finished, and outputting the third electric signal for 4 hours according to the third sensitive frequency and the third electric field intensity; meanwhile, the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group are adjusted 30 minutes after the third electric signal is output, and the fourth electric signal is output for 3 hours according to the fourth-level sensitive frequency and the fourth-level electric field intensity; and finally, adjusting the sensitive frequency and the alternating electric field intensity output by the second waveform generating circuit group 40 minutes after the fourth electric signal is output, and outputting the fifth electric signal for 3.2 hours according to the fifth sensitive frequency and the fifth electric field intensity.

The effect of the above technical scheme is as follows: the stimulation degree and the stimulation variation diversity of the tumor cells can be effectively improved through the arrangement of the output frequency of the alternating electric field and the electric field intensity, so that the condition that the stimulation effect is reduced due to the fact that the tumor cells are resistant to the electric signal frequency and the electric field intensity in the same range in the one-stage stimulation process is reduced, and the stimulation effect of the tumor cells is effectively improved.

Meanwhile, the tumor cell sample is stimulated through the mode and the specific range of the frequency and the electric field intensity, the range of the electric field device for treating the tumor condition can be enlarged, the obvious inhibition effect is basically realized for the common tumor cell condition in the frequency and electric field intensity setting range, in addition, the five-time frequency and electric field intensity replacement type alternate stimulation is combined with the duration coordination of the stimulation in each stage, the duration of the good stimulation effect of the tumor cell can be effectively prolonged, the condition that the stimulation effect is reduced due to the tolerance generated by the frequency of an electric signal and the electric field intensity in the same range is effectively prevented, and the tumor cell stimulation through the optimized value can greatly improve the stimulation effect of the tumor cell in most cases. On the other hand, when a stimulation pathology experiment is carried out on a tumor cell sample of an individual patient, the frequency and the specific electric field strength value with a good stimulation effect on the tumor cell sample of the patient can be quickly found through the range of the frequency and the range of the electric field strength, the acquisition time of the frequency and the specific electric field strength value corresponding to the good stimulation effect of the tumor cell is effectively shortened, the acquisition effect of the frequency and the specific electric field strength value corresponding to the good stimulation effect of the tumor cell is improved, and the patient can enter a specific treatment stage as soon as possible.

In one embodiment of the present invention, when the electric field device is used for alternating electric field stimulation of tumor cells, a first waveform generating circuit and a second waveform generating circuit can be used for alternating cell stimulation, if the first waveform generating circuit and the second waveform generating circuit are used alternately, the sensitive frequency range of the first waveform generating circuit is 30 KHz-650 KHz, and the electric field intensity is not less than 1.2V/cm; the sensitive frequency range of the second waveform generating circuit is 400 KHz-600 KHz, and the electric field intensity is not less than 1.5V/cm; and a use interval time period is set between the first waveform generating circuit and the second waveform generating circuit, and the use interval time period is obtained by the following formula:

wherein T represents a usage interval period; t is₁Representing the preset use time of the first waveform generating circuit; t is₂Representing the preset use time of the second waveform generation circuit; t is₀Indicating the standard time unit of time adjustment, T₀The value range of (A) is 1 hour to 2.5 hours, preferably 1.5 hours; alpha represents a time adjustment coefficient, and the value range of the alpha is 0.3-0.6, preferably 0.5; min (T)₁，T₂) Indicating selection at T₁And T₂The smallest one of the two. In particular, when the first wave is presetShape generation circuit service time T₁The preset use time T of the second waveform generation circuit is 4 hours₂Is 6 hours, the time is adjusted by a standard unit time length T₀Is 1.5 hours, and the time adjustment coefficient α is 0.5, the used interval time T is 0.7 hours, i.e., the used interval time is 42 minutes, through the calculation of the above formula.

The effect of the above technical scheme is as follows: in the application process of the actual electric field device, the variety of specific pathological conditions of a patient is very large, and various treatment schemes can be combined at will through the alternating electric fields with two different waveforms provided by the electric field device, but in the process of switching the alternating electric fields with two different waveforms, discomfort influence on the patient is avoided, a use time interval needs to be set in the alternate use process of the alternating electric fields with two different waveforms, and the problem that the whole stimulation time of tumor cells is increased due to overlong interval time can be effectively avoided under the condition that the stimulation time length of the tumor cells is reasonably prolonged through the use time interval obtained through the formula. Meanwhile, the use interval time obtained by the formula can effectively avoid discomfort to the patient, and effectively ensure that the stimulation effect of the adjacent alternating electric fields on the tumor cells is not influenced and reduced.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.