阅读说明：本技术 可调节八大智能及褪黑激素分泌的频率仿效反应声波方法 (Frequency-imitating reaction sound wave method capable of adjusting eight major intelligence and melatonin secretion ) 是由 许承兆 陈澂毅 李信达 于 2021-10-09 设计创作，主要内容包括：一种可调节八大智能及褪黑激素分泌的频率仿效反应声波方法,包含频率仿效反应声波的合成与建立步骤、建立频率仿效反应声波音乐步骤、大脑神经活动磁振造影数据以及大脑激素分泌量数据的收集与分析步骤,及建立生物指标步骤,其中所述大脑神经活动磁振造影数据以及大脑激素分泌量数据的收集与分析步骤,利用磁振造影以及离心萃取唾液技术,对外在导入的频率仿效反应声波音乐,所造成的大脑神经活动、褪黑激素分泌进行量化的数据收集及分析,并借此数据于所述建立生物指标步骤,建立出客观的生物指标,借此能有效地作为后续衍生产品及复健方式的设计根据。(A frequency-imitating reaction sound wave method capable of adjusting eight major intelligence and melatonin secretion comprises a synthesis and establishment step of the frequency-imitating reaction sound wave, a step of establishing frequency-imitating reaction sound wave music, a step of collecting and analyzing brain nerve activity magnetic vibration contrast data and brain hormone secretion data, and a step of establishing biological indexes, wherein the collecting and analyzing step of the brain nerve activity magnetic vibration radiography data and the brain hormone secretion data utilizes the magnetic vibration radiography and the centrifugal saliva extracting technology, the quantitative data collection and analysis are carried out on the brain nerve activity and the melatonin secretion caused by externally-introduced frequency simulation response sound wave music, and establishing objective biological indexes in the biological index establishing step by the data, thereby being effectively used as a design basis for subsequent derivative products and rehabilitation modes.)

1. A frequency imitation reaction sound wave method capable of adjusting eight major intelligence and melatonin secretion is characterized in that: comprises the following steps:

synthesizing and establishing frequency-simulated reaction sound waves, namely synthesizing forty frequency-simulated reaction sound waves with different frequencies by taking 100 Hz stable sound waves to be matched with 5-44 Hz oscillating sine waves and taking 1 Hz as a unit;

establishing frequency simulation reaction sound wave music, namely introducing the frequency simulation reaction sound waves into music tracks of a plurality of original music by a sound mixing method to prepare a plurality of frequency simulation reaction sound wave music, and dividing the frequency simulation reaction sound wave music into eight albums according to the frequency of the mixed frequency simulation reaction sound waves, wherein the frequencies of the frequency simulation reaction sound waves corresponding to the albums are respectively 5-9 Hz, 10-14 Hz, 15-19 Hz, 20-24 Hz, 25-29 Hz, 30-34 Hz, 35-39 Hz and 40-44 Hz in sequence;

collecting and analyzing the brain nervous activity magnetic resonance imaging data and the brain hormone secretion data, preparing a playing device, playing general music without frequency simulation response sound waves and music of at least one album to a subject by using the playing device, preparing an MRI apparatus and an analysis set after the album is played and the general music is played, collecting and analyzing the blood oxygen concentration consumption rate of the brain of the subject by using the MRI apparatus as the nerve activity intensity index of the brain after the album is played, wherein the album and the general music are played to the subject in the same time period of different days, and taking a certain amount of saliva of the subject before and after the album is played and before and after the general music is played, and extracting and analyzing the amount of melatonin in saliva before and after listening by centrifugal extraction using the analysis kit; and

a step of establishing a biological index, comprising a first substep and a second substep,

the first sub-step, analyzing and comparing the nerve activity intensity indexes obtained by the previous steps, analyzing and comparing the nerve activity intensity of the brain of the subject after listening to the general music and the album, finding out the unique nerve activity and the corresponding brain area which can be caused by the album and can not be caused by the general music, comparing the unique nerve activity and the corresponding brain area data which can be caused by the album with the brain function data related to the eight multivariate intelligence in the cognitive neuroscience literature, confirming the influence of the album on the brain nerve circuits related to the eight multivariate intelligence of the subject, and establishing an objective biological index for externally introducing frequency imitating response sound wave music to regulate and promote the brain,

the second substep subtracts the melatonin amount measured before and after listening from the melatonin amount measured in saliva after listening to the album to obtain the melatonin variation before and after listening to the album, subtracts the melatonin amount measured before and after listening to the general music from the melatonin amount measured in saliva after listening to the general music to obtain the melatonin variation before and after listening to the general music, and compares the melatonin variation before and after listening to the album and the positive and negative values of the melatonin variation before and after listening to the general music to establish an objective biological index simulating the regulation and promotion effects of the sound wave music on melatonin secretion at the introduction frequency.

2. The method of claim 1, wherein the frequency-emulating response sound waves are capable of adjusting the octave and melatonin secretion, and wherein: in the collecting and analyzing step of the neuro-magnetic resonance imaging data of the brain and the data of the secretion amount of the brain hormone, before and after the album and before and after the general music are played, a predetermined amount of saliva of the subject is taken, and the dehydroepiandrosterone amounts in the saliva before and after the album are extracted and analyzed by the centrifugal extraction using the analyzing kit, the establishing step of the bio-indicator further includes a third sub-step of subtracting the dehydroepiandrosterone amount measured before the listening from the dehydroepiandrosterone amount in the saliva measured after the album is listened to obtain dehydroepiandrosterone variation before and after the album is listened to, and subtracting the dehydroepiandrosterone amount measured before the listening from the dehydroepiandrosterone amount in the saliva measured after the listening to the general music to obtain dehydroepiandrosterone variation before and after the listening to the general music, and comparing the variation of the dehydroepiandrosterone before and after the album is listened and the positive and negative values of the variation of the dehydroepiandrosterone before and after the common music is listened so as to establish an objective biological index for regulating and promoting the dehydroepiandrosterone secretion by externally-introduced frequency simulation reaction sound wave music.

Technical Field

The invention relates to a method for introducing frequency-imitating reaction sound waves into music, in particular to a frequency-imitating reaction sound wave method capable of adjusting eight major intelligence and melatonin secretion.

Background

According to the past evidence and technology, only brain wave frequency energy adjustment corresponding to brain wave outside skull and frequency simulation reaction is provided, the invention adopts a method of sound wave mixing combined with magnetic vibration radiography and centrifugal saliva extraction technology for the first time, and provides adjustment of different nerve circuits corresponding to eight multivariate intelligence in the brain and influence on variation of hormone secretion.

Frequency modeling Response (hereinafter referred to as FFR) is a physiological phenomenon in which the activity Frequency of neurons in the brain is synchronized with the Frequency of external stimuli. Therefore, we can guide the activity frequency of neurons in the brain by means of auditory tones, visual flashing lights, tactile taps, and the like. There have been many studies demonstrating that frequency-mimicking reactions can bring about beneficial physiological and psychological effects, and therefore have great research prospects and the potential to be an alternative and complementary therapeutic modality.

On the other hand, the multivariate intelligent theory applied to the field of education was proposed by the psychologist Gardner of the university of Harvard institute in 1983. Gardner proposed the present theory from studying the differences in learning ability of brain-injured patients. Although the multiple intelligence is divided into such details according to the innate endowments, the intelligence can not be used for limiting people to be a certain intelligence type, and every person has a unique set of intelligence combination system. According to the existing evidence, human intelligence can be divided into at least eight categories, including language intelligence, logic mathematics intelligence, space intelligence, limb kinesthetic intelligence, music intelligence, interpersonal intelligence, introspection intelligence and natural observation intelligence.

Through studies in patients with brain injury, disease or injury in certain areas of the brain selectively impairs certain intelligence while leaving other intelligence intact. For example, damage to the bromocard area in the left frontal lobe of the brain can disrupt a person's ability to speak or read, but the person is often still able to draw, hum, skate, or smile because these functions are related to the intact area of the brain. However, individuals with lesions on the right apparent lobe may lose the ability to modulate pitch, but retain the ability to speak, read, and write. In general, existing evidence indicates that the corresponding associated major brain regions in the eight diverse intellectuals are as follows: the Chinese intelligence: left emerging and frontal lobe; logical mathematical intelligence: left prefrontal and right parietal lobes; space intelligence: occipital and parietal areas (especially the right hemisphere); the kinesthetic sensation of the limbs is intelligent: cerebellum, basal ganglia, motor cortex; music intelligence: right leaf development; interpersonal intelligence: anterior lobe, apparent lobe (especially right hemisphere), limbic system; internal province intelligence: frontal, parietal, limbic systems; the natural observation intelligence: the left apical leaf (important for distinguishing "living" from "non-living").

The brain can control the above intelligent performance, and also influence the physiological performance of the human body through the hormones, wherein Melatonin (Melatonin) can influence sleep time and regulate blood pressure, and Dehydroepiandrosterone (Dehydroepiandrosterone, secreted by the brain, adrenal gland and gonad) can strengthen muscles, stabilize the production of sex hormones, maintain mineral balance, dilate blood vessels, prevent aging, etc. It is known that melatonin and dehydroepiandrosterone secretion may be related to sunlight or some external stimuli, but it is determined that both hormones decrease with age, so that in order to avoid the negative effects of the decrease in both hormones, the hormone supplementation with drugs is now performed with significant effect.

Therefore, we know from past studies that: (1) the frequency-emulating response can pull brain activity at a specific frequency; (2) eight multivariate intelligent nerve bases are correspondingly formed by different brain areas; (3) the hormone secreted by the brain can control the physiological performance of the human body.

However, the frequency-emulating response bands that can regulate the neural circuits associated with the eight major multiple intelligence and regulate the secretion of cerebral hormones are still unknown today. Furthermore, only the influence of the brain wave frequency energy corresponding to the frequency-emulating response of the extracranial brain waves has been provided in the past.

Disclosure of Invention

The invention aims to provide a frequency imitation response sound wave method which can be used for establishing objective biological indexes and can adjust eight major intelligence and melatonin secretion aiming at frequency imitation response sound wave music.

The frequency-emulated reaction sound wave method capable of adjusting eight major intelligence and melatonin secretion comprises a step of synthesizing and establishing frequency-emulated reaction sound waves, a step of establishing frequency-emulated reaction sound waves and music, a step of collecting and analyzing brain nerve activity magnetic resonance imaging data and brain hormone secretion data, and a step of establishing biological indexes.

The synthesis and establishment steps of the frequency-simulated reaction sound waves are that stable sound waves of 100 Hz are matched with oscillatory sine waves of 5-44 Hz, and forty frequency-simulated reaction sound waves of different frequencies are synthesized in total by taking 1 Hz as a unit.

The step of establishing frequency-simulated reaction sound wave music is to introduce the frequency-simulated reaction sound waves into music tracks of a plurality of original music by a sound mixing method to prepare a plurality of frequency-simulated reaction sound wave music, divide the frequency-simulated reaction sound wave music into eight albums according to the frequency of the mixed frequency-simulated reaction sound waves, and divide the frequency of the frequency-simulated reaction sound waves corresponding to the albums into 5-9 Hz, 10-14 Hz, 15-19 Hz, 20-24 Hz, 25-29 Hz, 30-34 Hz, 35-39 Hz and 40-44 Hz respectively in sequence.

Collecting and analyzing the brain nerve activity magnetic resonance imaging data and the brain hormone secretion data, preparing a playing device, playing general music without frequency simulation response sound waves and music of at least one album separately to a subject by using the playing device, preparing an MRI apparatus and an analysis set after the album is played and the general music is played, collecting and analyzing the blood oxygen concentration consumption rate of the brain of the subject by using the MRI apparatus as an index of the nerve activity intensity of the brain after the album is played, wherein the album and the general music are played to the subject for listening in the same time period of different days respectively, and taking a quantitative amount of saliva of the subject before and after the album is played and before and after the general music is played, and using the assay kit to extract and analyze the amount of melatonin in saliva before and after listening by centrifugal extraction.

The step of establishing a biological indicator includes a first substep and a second substep. The first sub-step analyzes and compares the nerve activity intensity indexes obtained in the previous steps after the subject listens to the general music and the album, finds out the unique nerve activity and the corresponding brain area which can be caused by the album and can not be caused by the general music, compares the unique nerve activity and the corresponding brain area data which can be caused by the album with the brain function data related to the eight multivariate intelligence in the cognitive neuroscience literature to confirm the influence of the album on the brain nerve circuits related to the eight multivariate intelligence of the subject, and establishes an objective biological index for externally introducing frequency simulation response sound wave music to the brain and promoting the effect.

The second substep subtracts the melatonin amount measured before and after listening from the melatonin amount measured in saliva after listening to the album to obtain the melatonin variation before and after listening to the album, subtracts the melatonin amount measured before and after listening to the general music from the melatonin amount measured in saliva after listening to the general music to obtain the melatonin variation before and after listening to the general music, and compares the melatonin variation before and after listening to the album and the positive and negative values of the melatonin variation before and after listening to the general music to establish an objective biological index simulating the regulation and promotion effects of the sound wave music on melatonin secretion at the introduction frequency.

The present invention provides a frequency-simulated response sound wave method capable of adjusting eight smarts and melatonin secretion, wherein in the collecting and analyzing step of the cerebral nerve activity magnetic resonance imaging data and the cerebral hormone secretion data, before and after the album playing and before and after the general music playing, a certain amount of saliva of the subject is taken, and the dehydroepiandrosterone amount in the saliva before and after listening is extracted and analyzed by using the analyzing kit in a centrifugal extraction manner, the establishing step further comprises a third sub-step of subtracting the dehydroepiandrosterone amount measured before listening from the dehydroepiandrosterone amount in the saliva measured after listening to the album to obtain dehydroepiandrosterone variation before and after listening to the album, and subtracting the dehydroepiandrosterone amount measured before listening from the dehydroepiandrosterone amount in the saliva measured after listening to the general music, and comparing the dehydroepiandrosterone variation before and after the album is listened with the dehydroepiandrosterone variation before and after the common music is listened to establish objective biological indexes of regulating and promoting effect of external frequency introduction simulation reaction sound wave music on dehydroepiandrosterone secretion.

The invention has the beneficial effects that: the invention adopts the method of sound mixing, magnetic vibration radiography and centrifugal saliva extraction technology for the first time, can imitate and react sound music to the externally introduced frequency to cause the regulation effect of the brain nerve activity and melatonin secretion, establishes objective biological indexes, and can be effectively used as the design basis of subsequent derivative products and rehabilitation modes.

Drawings

FIG. 1 is a flow chart of one embodiment of the present invention for adjusting the octave and frequency-emulating response sound wave method of melatonin secretion;

FIG. 2 is a magnetic resonance image data obtained by the embodiment applied to a female subject; and

FIG. 3 is a magnetic resonance image data obtained by the embodiment applied to a male subject.

Detailed Description

The present invention will be described in detail below with reference to the accompanying drawings and examples.

Referring to fig. 1, an embodiment of the method for adjusting the frequency-simulated response sound waves of the eight smarts and melatonin secretion of the present invention includes a step S1 of synthesizing and establishing the frequency-simulated response sound waves, a step S2 of establishing frequency-simulated response sound waves, a step S3 of collecting and analyzing the magnetic resonance imaging data of the brain nerve activity and the data of the brain hormone secretion amount, and a step S4 of establishing a biological index.

In the step S1 of synthesizing and establishing frequency-simulated response sound waves, stable sound waves of 100 hz and sine waves oscillating at 5 to 44 hz are prepared, and forty frequency-simulated response sound waves of different frequencies are synthesized in 1 hz. In detail, the frequency-emulating response sound wave can be transmitted into the ear through the stably oscillating audio frequency and trigger the brain neurons to generate the frequency-emulating response.

The step S2 of creating frequency-simulated response sound music includes introducing the frequency-simulated response sound into the tracks of the original music by a sound mixing method to produce a plurality of frequency-simulated response sound music, and dividing the frequency-simulated response sound music into eight albums according to the frequency of the mixed frequency-simulated response sound, wherein the frequency of the frequency-simulated response sound corresponding to the albums is 5 to 9 hz, 10 to 14 hz, 15 to 19 hz, 20 to 24 hz, 25 to 29 hz, 30 to 34 hz, 35 to 39 hz, and 40 to 44 hz respectively.

The collecting and analyzing step S3 comprises preparing a playing device, playing a general music and at least one album music without frequency-simulated response sound waves separately to the subject by using the playing device, preparing an mri apparatus and an analyzing set after the album is played and the general music is played, collecting and analyzing the blood oxygen concentration consumption rate of the brain of the subject by using the mri apparatus as an index of the nerve activity of the brain after the album is played, wherein the album and the general music are played to the subject for the same time period of different days and before and after the album is played and before and after the general music is played, a quantitative amount of saliva of the subject is taken, and the amount of melatonin and dehydroepiandrosterone in the saliva before and after listening is extracted and analyzed by centrifugal extraction using the analysis kit. In other embodiments, one album or two or more albums may be selected to be individually played to the subject for listening according to the detection requirement.

In this embodiment, the acquisition and analysis of the magnetic resonance imaging data of the brain nerve activity is performed by performing experiments with Magnetic Resonance Imaging (MRI) at 3T, a core facility of university of yangming, acquiring image data, analyzing the data (Statistical Parametric mapper) with a free image processing system developed by the university of london college (wellcom center for Neuroimaging), and presenting data results through a brain coordinate platform (MNI coordinates) established by Montreal Neurological Institute and Hospital.

The reference website is as follows:

(1) yangming university core facility 3T Magnetic Resonance Imaging (MRI): http:// bclab. ym.edu.tw/mri _ website/mri _ index. html

(2) Free image processing system developed by the university of London institute (Wellcome Trust center for Neuroimaging) analyzes data (Statistical Parametric mapper): https:// www.fil.ion.ucl.ac.uk/spm

(3) Brain coordinate platforms (MNI coordinates) established by the Montreal Neurological Institute and Hospital: https:// imaging. mrc-cbu.cam. ac.uk @

In this example, melatonin and dehydroepiandrosterone were extracted by centrifugation using a commercially available analytical kit, the Elisa kit, according to the manufacturer's instructions.

The step of establishing a biological index S4 includes a first sub-step, a second sub-step, and a third sub-step.

The first sub-step is to analyze and compare the nerve activity intensity indexes obtained in the previous steps, to find out the nerve activity and corresponding brain area which can not be caused by the common music and is unique to the album, to compare the unique nerve activity and corresponding brain area data which can be caused by the album and the brain function data related to the eight multivariate intelligence in the cognitive neuroscience literature, to confirm the influence of the album on the brain nerve circuits related to the eight multivariate intelligence of the subject, and to establish an objective biological index for externally introducing frequency imitating response sound wave music to regulate and promote the effect of the brain.

The second substep is to subtract the melatonin amount measured before and after listening to the album from the melatonin amount measured in saliva after listening to the album to obtain the melatonin variation before and after listening to the album, to subtract the melatonin amount measured before and after listening to the general music from the melatonin amount measured in saliva after listening to the general music to obtain the melatonin variation before and after listening to the general music, and to compare the positive and negative values of the melatonin variation before and after listening to the album and the melatonin variation before and after listening to the general music to establish an objective biological index simulating the regulation and promotion effects of the sound wave music on the melatonin secretion at the introduction frequency.

The third substep is to subtract the dehydroepiandrosterone amount in saliva measured after listening to the album from the dehydroepiandrosterone amount measured before listening to the album to obtain dehydroepiandrosterone variation before and after listening to the album, subtract the dehydroepiandrosterone amount in saliva measured after listening to the general music to obtain dehydroepiandrosterone variation before and after listening to the general music, and compare the dehydroepiandrosterone variation before and after listening to the album and the dehydroepiandrosterone variation before and after listening to the general music to establish an objective biological indicator of the regulation and promotion effect of the external frequency-introduced simulated-response acoustic music on the dehydroepiandrosterone secretion.

Referring to fig. 2 and 3, the method of the present embodiment is applied to a healthy and voluntarily participating male subject and a healthy and voluntarily participating female subject, wherein the female subject listens to the general music and the music on the album, the male subject listens to the general music and the music on five albums, fig. 2 is the magnetic resonance imaging data of the female subject listening to the music on the album, and fig. 3 is the magnetic resonance imaging data of the male subject listening to the music on 5 albums.

The modulation of the nervous system in the brain of the female subject by the frequency-emulating response sound wave music obtained by the present embodiment is as follows:

5-9 Hz: adjustable logical mathematical intelligence related brain regions;

10-14 Hz: the related brain areas of space intelligence and limb kinesthesis intelligence can be adjusted;

20-24 Hz: the related brain areas of music intelligence and interpersonal intelligence can be adjusted;

25-29 Hz: adjustable intemal intelligence related brain regions;

30-34 Hz: the related brain areas of the Chinese intelligence and the interpersonal intelligence can be adjusted;

35-39 Hz: the related brain areas of natural observation intelligence and logic mathematics intelligence can be adjusted;

40-44 Hz: the intelligent and naturally observed relevant brain areas of the introspection can be adjusted.

The regulation of the brain system of the male subject by the frequency-simulated response sound wave music obtained by the embodiment is as follows:

5-9 Hz: the related brain areas of Chinese intelligence and logic mathematics intelligence can be adjusted;

10-14 Hz: adjustable spatial intelligence related brain regions;

15-19 Hz: the related brain area of the limb kinesthetic intelligence can be adjusted;

20-24 Hz: related brain areas of interpersonal intelligence and introspection intelligence can be adjusted;

25-29 Hz: the related brain areas of the adjustable music intelligence, the limb kinesthetic intelligence, the logic mathematics intelligence and the space intelligence.

Wherein, the female subject and the male subject correspond to the frequency-simulated response brain activity region of the sound wave music, the activity statistics and the test value as follows:

in addition, the present embodiment is also applicable to another healthy and voluntary female subject and another healthy and voluntary male subject, wherein both the female subject and the male subject listen to the general music and the album with the frequency of the frequency emulating reaction sound waves of 10-14 Hz. The female subjects and the male subjects had the following frequency patterns corresponding to the albums, which were adjusted according to the amounts of melatonin and dehydroepiandrosterone secretion in the music of the music:

as can be seen from the above, the method of the present embodiment can provide objective and individual biological indicators for each subject according to the frequency of the specific frequency to be tested. In addition, the method of the embodiment can also provide objective and quantitative biological indexes for a plurality of subjects, and further observe whether the frequency of the specific frequency reflects the adjustment result of the sonic music on the plurality of subjects to be consistent or not.

In summary, the method for adjusting frequency-simulated response sound waves of eight intellectuals and melatonin secretion of the invention adopts sound wave mixing combined with magnetic vibration imaging and centrifugal saliva extraction technology for the first time, can simulate response sound waves music to the externally introduced frequency, so as to cause the adjusting effects of brain nerve activity, melatonin secretion and dehydroepiandrosterone secretion, establish objective biological indexes, and can be effectively used as the design basis of subsequent derivative products and rehabilitation modes, thereby really achieving the purpose of the invention.

It should be understood that the above description is only exemplary of the present invention, and should not be taken as limiting the scope of the invention, which is defined by the appended claims and their equivalents.