阅读说明：本技术 一种红外复合皮层电极和监测系统 (Infrared composite cortical electrode and monitoring system ) 是由 陈晗青 安小广 龙新云 于 2021-07-12 设计创作，主要内容包括：本申请涉及一种红外复合皮层电极和监测系统,皮层电极包括皮层电极本体和红外探头,皮层电极本体包括片状基底、部分设置于片状基底本体内的第一连接线以及设置于片状基底上且与第一连接线连接的电极点,电极点设置在片状基底的下表面；红外探头设置于片状基底,与部分设置在片状基底内的第二连接线连接；其中,红外探头包括近红外探头和/或中红外探头,片状基底和/或电极点被配置为不遮挡红外探头发出的红外光。本申请的红外探头能够在植入大脑皮层时对浅脑层组织成像,并且设置在皮层电极上的红外探头能够调节神经细胞的活动,在将具有电极点和红外探头的皮层电极植入大脑皮层时,只需承受与原有的皮层电极相同的创伤,提高手术的安全性。(The application relates to an infrared composite cortical electrode and a monitoring system, wherein the cortical electrode comprises a cortical electrode body and an infrared probe, the cortical electrode body comprises a flaky substrate, a first connecting wire and an electrode point, the first connecting wire is partially arranged in the flaky substrate body, the electrode point is arranged on the flaky substrate and is connected with the first connecting wire, and the electrode point is arranged on the lower surface of the flaky substrate; the infrared probe is arranged on the sheet-shaped substrate and is connected with a second connecting wire which is partially arranged in the sheet-shaped substrate; wherein the infrared probe comprises a near infrared probe and/or a middle infrared probe, and the sheet-shaped substrate and/or the electrode points are configured not to shield infrared light emitted by the infrared probe. The utility model provides an infrared probe can be when implanting cerebral cortex to the formation of image of shallow cerebral cortex tissue to the activity that sets up infrared probe on cortical electrode can adjust nerve cell only needs bear the wound the same with original cortical electrode when the cortical electrode that will have electrode point and infrared probe is implanted cerebral cortex, improves the security of operation.)

1. An infrared composite skin electrode, comprising:

the cortical electrode comprises a laminar substrate (1), a first connecting line (4) partially arranged in the laminar substrate (1) and an electrode point (2) arranged on the laminar substrate (1) and connected with the first connecting line (4), wherein the electrode point (2) is arranged on the lower surface of the laminar substrate (1);

the infrared probe (3) is arranged on the sheet-shaped substrate (1) and is connected with a second connecting line (5) which is partially arranged in the sheet-shaped substrate (1);

wherein the infrared probe (3) comprises a near-infrared probe (3) and/or a mid-infrared probe (3), and the sheet-like substrate (1) and/or the electrode points (2) are configured not to block infrared light emitted by the infrared probe (3).

2. The infrared composite skin electrode according to claim 1, wherein the infrared probe (3) is disposed on the lower surface of the sheet-like substrate (1).

3. The infrared composite skin electrode according to claim 1, wherein the electrode points (2) are distributed in a single row or multiple rows on the sheet-like substrate (1).

4. An infrared composite skin electrode according to claim 3, characterized in that a plurality of said infrared probes (3) are arranged around each of said electrode points (2).

5. An infrared composite skin electrode according to claim 4, characterized in that a plurality of said infrared probes (3) are evenly distributed around said electrode point (2).

6. The infrared composite skin electrode according to claim 3, wherein the infrared probes (3) and the electrode points (2) are distributed on the lower surface of the sheet-shaped substrate (1) in a staggered manner.

7. The infrared composite cortical electrode of claim 1, wherein the electrode points (2) comprise annular electrode points (2), the infrared probe (3) is embedded in the annular electrode, and the infrared probe (3) is flush with the lower surface of the annular electrode points (2).

8. A monitoring system comprising any of claims 1 to 7, further comprising a multimodal brain-machine interface subsystem (6), the multimodal brain-machine interface subsystem (6) being connected with the first connection line (4) and/or the second connection line (5) in the infrared composite cortical electrodes.

Technical Field

The application relates to the technical field of medical equipment monitoring, in particular to an infrared composite cortical electrode and a monitoring system.

Background

At present, infrared probes of infrared imaging products are only distributed on the surface of a scalp, collected signals are formed by synchronously summing postsynaptic potentials of a large number of nervous tissues, but due to the fact that complexity of human tissues and thickness of the scalp are different from person to person, obtained data need to be corrected through software, and certain deviation exists inevitably. The infrared light can penetrate through the cerebral scalp and the skull to enter a cerebral cortex cortical area with the depth of 2-3cm below the scalp, the depth of the collected signals is limited, and the electrical activity of a single neuron is very small and cannot be recorded on the scalp, and the infrared light also has no function of regulating the activity of nerve cells.

Disclosure of Invention

The application provides an infrared composite cortical electrode and monitoring system, can be in the formation of image of cerebral cortex when detecting the brain electricity to can adjust nerve cell activity.

In a first aspect, the application provides an infrared composite cortical electrode, which adopts the following technical scheme:

an infrared composite skin electrode comprising:

the cortical electrode comprises a flaky substrate, a first connecting wire and an electrode point, wherein the first connecting wire is partially arranged in the flaky substrate, the electrode point is arranged on the flaky substrate and is connected with the first connecting wire, and the electrode point is arranged on the lower surface of the flaky substrate;

the infrared probe is arranged on the sheet-shaped substrate and is connected with a second connecting line which is partially arranged in the sheet-shaped substrate;

wherein the infrared probe comprises a near infrared probe and/or a mid-infrared probe, and the sheet-shaped substrate and/or the electrode points are configured not to shield infrared light emitted by the infrared probe.

Through adopting above-mentioned technical scheme, the cortical electrode includes the cortical electrode body, the cortical electrode body includes the slice basement, the part sets up this internal first connecting wire of slice basement and sets up on the slice basement and with the electrode point of first connecting wire connection, can implant the pallium through the operation, with the laminating of pallium, be provided with infrared probe on the cortical electrode, can implant pallium at infrared probe and make and form images to shallow cortex tissue, and the activity of nerve cell can be adjusted to the infrared probe of setting on the cortical electrode, and simultaneously, when the pallium is implanted to the cortical electrode that will have electrode point and infrared probe, only need bear the wound the same with original cortical electrode, improve the security of operation.

Optionally, the infrared probe is disposed on a lower surface of the sheet-like base.

Through adopting above-mentioned technical scheme, infrared probe can press close to the cerebral cortex for the formation of image is more clear.

Optionally, the electrode points are distributed on the sheet-shaped substrate in a single row or multiple rows.

Optionally, a plurality of said infrared probes are provided around each said electrode point.

By adopting the technical scheme, the infrared probe can image around the electrode point, so that the imaging data around the electrode point can be monitored conveniently.

Optionally, a plurality of the infrared probes are evenly distributed around the electrode point.

By adopting the technical scheme, the infrared probes are uniformly distributed around the electrode points, so that the imaging rule is favorably obtained.

Optionally, the infrared probes and the electrode points are distributed on the lower surface of the sheet-shaped substrate in a staggered manner.

By adopting the technical scheme, the infrared probe and the electrode points are distributed in a staggered manner, so that the electroencephalogram signal and infrared imaging data are uniformly monitored.

Optionally, the electrode points include annular electrode points, the infrared probe is embedded in the annular electrode, and the infrared probe is flush with the lower surface of the annular electrode points.

Through adopting above-mentioned technical scheme, can be that cortex electrode body laminates the cerebral cortex better.

In a second aspect, the present application provides a monitoring system as defined in any one of the first aspect, wherein the following technical solutions are adopted:

the monitoring system further comprises a multi-modal brain-computer interface subsystem, and the multi-modal brain-computer interface subsystem is connected with a first connecting wire and/or a second connecting wire in the composite intracranial cortical electrode.

By adopting the technical scheme, the first connecting wire and/or the second connecting wire of the composite intracranial cortical electrode are/is connected to the multi-mode brain-computer interface subsystem, so that multi-mode brain imaging information can be obtained while the cortical electrode collects brain electroencephalogram signals and local heat coagulation, multi-mode brain function information data is formed, and the method has important guiding significance in clinical research.

The application discloses an infrared compound cortex electrode, cortex electrode includes the cortex electrode body, the cortex electrode body includes the slice base, the part sets up at this internal first connecting wire of slice base and sets up on the slice base and the electrode point of being connected with first connecting wire, can implant the cortex through the operation, with the laminating of cortex, be provided with infrared probe on the cortex electrode, can implant the cortex messenger at infrared probe and form images to intracranial shallow cortex tissue, and the activity of nerve cell can be adjusted to the infrared probe of setting on the cortex electrode, and simultaneously, when the cortex electrode that will have electrode point and infrared probe implants the cortex, only need bear the wound the same with original cortex electrode, improve the security of operation.

Drawings

Fig. 1 is a schematic diagram of an overall structure of an infrared composite skin electrode according to an embodiment of the present disclosure.

Fig. 2 is an enlarged view of a in fig. 1.

Fig. 3 is a schematic view of one manner of mounting the electrode points and the infrared probe in the embodiment of the present application.

Fig. 4 is another overall structure diagram of an infrared composite skin electrode according to an embodiment of the present application.

Fig. 5 is a schematic view showing another mounting manner of the electrode points and the infrared probe in the embodiment of the present application.

FIG. 6 is a schematic structural diagram of an infrared composite skin electrode and a monitoring system according to an embodiment of the present disclosure.

Description of reference numerals: 1. a sheet-like substrate; 2. an electrode point; 3. an infrared probe; 4. a first connecting line; 5. a second connecting line; 6. a multi-modal brain-machine interface subsystem.

Detailed Description

Various exemplary embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings. It should be noted that: the relative arrangement of the components and steps, the numerical expressions, and numerical values set forth in these embodiments do not limit the scope of the present disclosure unless specifically stated otherwise.

Near-infrared spectroscopy (NIRS) is a recent non-invasive optical imaging technique that uses the change in oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (Hb) content associated with cortical regions during brain activity to obtain brain function information. The absorption of oxyhemoglobin and deoxyhemoglobin to a near infrared band (650-950 nm) is very small, and the characteristic enables near infrared light to penetrate through the scalp and skull of a brain and enter a cerebral cortex area 2-3cm deep below the scalp. When the activity of a localized area of the cerebral cortex increases, the blood flow increases, causing the oxygenated hemoglobin content to increase and the deoxygenated hemoglobin content to decrease. Oxyhemoglobin and deoxyhemoglobin have different spectral absorption characteristics, near infrared light with more than two different wavelengths is incident from a certain point of the brain scalp, the change of the irradiated light is detected from a position which is a few centimeters away from the incident point (2-5 cm is an optimal distance internationally recognized), and the content change of the oxyhemoglobin and the deoxyhemoglobin can be calculated reversely, so that the brain function activation characteristics are obtained.

At present, the infrared probes 3 of the infrared imaging product are only distributed on the surface of the scalp, the collected signals are formed by synchronously summing the postsynaptic potentials of a large number of nervous tissues, but the complexity of human tissues and the thickness of the scalp vary from person to person, so the obtained data needs to be corrected by software, and certain deviation exists inevitably. Moreover, infrared light can penetrate through the cerebral scalp and the skull to enter a cerebral cortex area with the depth of 2-3cm below the scalp, the depth of collected signals is limited, and the electrical activity of a single neuron is very tiny and cannot be recorded on the scalp.

In order to solve the above problems, embodiments of the present application provide an infrared composite cortical electrode and a monitoring system.

Referring to fig. 1 and 2, the composite intracranial cortical electrode comprises a cortical electrode body and an infrared probe 3 arranged on the cortical electrode body; the cortical electrode body comprises a sheet-shaped substrate 1, a first connecting line 4 partially arranged in the sheet-shaped substrate 1 and an electrode point 2 arranged on the sheet-shaped substrate 1 and connected with the first connecting line 4, an infrared probe 3 is arranged on the sheet-shaped substrate 1 and connected with a second connecting line 5 partially arranged in the sheet-shaped substrate 1, wherein the electrode point 2 is arranged on the lower surface of the sheet-shaped substrate 1, and the sheet-shaped substrate 1 and/or the electrode point 2 are/is configured not to shield infrared light emitted by the infrared probe 3.

The cortex electrode can be placed in encephalic dura mater through surgery, attach the cortex electrode on the cerebral cortex surface, make the electrode point 2 and the contact of cerebral cortex of cortex electrode, implant encephalic back at the cortex electrode, can detect EEG signal through electrode point 2 on the cortex electrode, infrared probe 3 through on the cortex electrode utilizes infrared spectrum technique to image encephalically simultaneously, thereby study the infrared imaging data that the change region corresponds according to EEG signal's change, in order to draw the activity change information of intracerebral nerve unit in space and time. And when the focal part is subjected to overheating coagulation, the method is helpful for researchers to pre-judge the required time of the overheating coagulation and monitor the overheating coagulation degree through infrared imaging data through electroencephalogram signals and infrared imaging data.

In this application embodiment, the mode through the operation is placed cortical electrode in cerebral cortex surface for infrared probe 3 can be together implanted intracranial, and form images to intracranial shallow brain tissue, can utilize electrode point 2 monitoring brain electrical signal on the cortical electrode simultaneously, when implanting this application cerebral cortex surface, only need bear the wound the same with original cortical electrode, has improved the security of operation.

It should be noted that the infrared probe 3 includes a near-infrared probe 3 and/or a mid-infrared probe 3. Both near infrared light and mid-infrared light in the infrared light can directly act on nerve tissues, so that the action potential on neurons can be activated or inhibited from being released, and the function of the brain can be regulated. The action mechanism of near-infrared nerve stimulation is generally considered as photothermal action, namely infrared light is absorbed by water to generate heat, and the sudden change of temperature generates transmembrane capacitance current on cells or activates a heat sensitive ion channel, so that the electrical activity of nerve cells is influenced. The photothermal action of the mid-infrared light is weaker than that of the near-infrared light, the nerve cell activity is difficult to regulate and control through the photothermal action, and the principle that the mid-infrared light regulates the nerve cell activity is as follows: the generation of action potential depends on the activity of ion channel proteins on cell membranes (including opening, closing, ion screening, permeability and the like of channels), particularly voltage-gated sodium channels and potassium channels, and the vibration frequency of chemical bonds in the biomacromolecules is in the middle infrared region. The function of regulating and controlling the channel can be realized by forming resonance between the mid-infrared light with specific frequency and the key chemical bond of the ion channel, so that the electrical activity of the neuron is influenced.

Referring to fig. 1 and 2, in the present embodiment, the sheet-shaped substrate 1 may be a square sheet-shaped substrate 1, and the electrode points 2 are distributed in a single row or multiple rows on the sheet-shaped substrate 1, and the distances between the electrode points 2 in the same row are equal.

Referring to fig. 3, the electrode point 2 may be in a shape of a stepped truncated cone, when the skin layer electrode is manufactured, the electrode point 2 and the sensing element may be placed at preset positions in a mold for casting the sheet-shaped substrate 1, then the liquid-shaped substrate is cast in the mold, after the substrate is solidified, the sheet-shaped electrode is formed, and the electrode point 2 of the finished skin layer electrode is partially fixed in the sheet-shaped substrate 1 and partially exposed from the lower surface of the sheet-shaped substrate 1.

In the embodiment of the present application, referring to fig. 4, the infrared probes 3 are distributed in a single row or multiple rows on the sheet-shaped substrate 1, specifically, the infrared probes 3 may be disposed between two electrode points 2 in each row, the electrode points 2 and the infrared probes 3 are distributed alternately, and further, in each row, the distance between the infrared probe 3 and two adjacent electrode points 2 is equal.

In some embodiments, referring to fig. 1 and 2, the plurality of electrode points 2 around each electrode point 2 may be uniformly distributed, for example, 4 infrared probes 3 are surrounded around each electrode point 2, and the 4 infrared probes 3 are uniformly distributed at intervals of 90 °; so that the infrared probe 3 can be imaged uniformly around the electrode spot 2.

In some embodiments, the infrared probe 3 may be irregularly arranged on the sheet-like base 1 as long as it does not interfere with the position of the electrode point 2.

Specifically, a plurality of infrared probes 3 may be provided around each electrode point 2, and the infrared probes 3 are irregularly distributed around the electrode point 2.

When the cortical electrode is manufactured, the infrared probe 3 and the electrode point 2 can be placed at a preset position of a die, the electrode point 2 is connected with the first connecting line 4, the infrared probe 3 is connected with the second connecting line 5, then the liquid substrate is poured in the die, and the flaky electrode is formed after the substrate is solidified. After the sheet-shaped electrode is manufactured, the infrared probe 3 and the electrode point 2 are both positioned on the lower surface of the sheet-shaped substrate 1 and are partially exposed from the lower surface.

It should be noted that each electrode point 2 corresponds to one first connection line 4, and each infrared probe 3 corresponds to one second connection line 5.

In other embodiments, referring to fig. 5, electrode point 2 can be annular electrode point 2, and infrared probe 3 inlays and establishes in electrode point 2 to infrared probe 3's lower surface and electrode point 2's lower surface parallel and level make after implanting the cerebral cortex surface with this application, annular electrode point 2 and the laminating of cerebral cortex can not be influenced in infrared probe 3's setting, and annular electrode point 2 can not shelter from infrared probe 3's infrared light.

On the other hand, referring to fig. 6, the embodiment of the present application further provides a monitoring system, which includes the above-mentioned composite intracranial cortical electrode and a multi-modal brain-machine interface subsystem 6, where the multi-modal brain-machine interface subsystem 6 is connected to the first connecting wire 4 and/or the second connecting wire 5 in the composite intracranial cortical electrode.

The multi-mode brain-computer interface subsystem 6 can monitor electroencephalogram signals and infrared imaging information in real time, and users can monitor electroencephalogram signals and near-infrared imaging data through the man-machine exchange interface of the multi-mode brain-computer interface subsystem 6 and can perform related operations such as thermosetting and the like when necessary.

In the embodiment of the application, the first connecting wire 4 and/or the second connecting wire 5 in the composite intracranial cortical electrode are/is connected to the multi-mode brain-computer interface subsystem 6, so that multi-mode brain imaging information can be obtained while the cortical electrode collects cerebral cortex electroencephalogram signals and local thermocoagulation, multi-mode brain function information data is formed, and the composite intracranial cortical electrode has important guiding significance in clinical research.

The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.