阅读说明：本技术 用于回旋加速器液体靶的靶水定量分配装置 (Target water quantitative distribution device for liquid target of cyclotron ) 是由 刘治国 付正 卢洁 贾永峰 邓伟 于 2021-03-31 设计创作，主要内容包括：本发明公开了一种用于回旋加速器液体靶的靶水定量分配装置,属于核医学与分子影像学领域,其结构包括加速器端1通n分配阀、定量端1通n分配阀、注射组件、靶水中转瓶,其中：所述加速器端1通n分配阀的至少一个通道接加速器,用于将加速器产生的靶水输送至靶水中转瓶或热室；所述定量端1通n分配阀的至少一个通道接注射组件,至少一个通道接靶水中转瓶,用于将靶水中转瓶中的靶水输送至加速器端1通n分配阀管线。与现有技术相比,本发明的用于回旋加速器液体靶的靶水定量分配装置不仅可以实现高活度靶水的定向、定量分配,而且大大提高了医用回旋加速器和靶水等高值耗材的使用效能,克服了以往高活度靶水只能定向(1-2个热室)传输,无法自动化定量分配的问题。(The invention discloses a target water quantitative distribution device for a liquid target of a cyclotron, which belongs to the field of nuclear medicine and molecular imaging, and structurally comprises an accelerator end 1-way n distribution valve, a quantitative end 1-way n distribution valve, an injection assembly and a target water rotary bottle, wherein: the accelerator end 1 is connected with an accelerator through at least one channel of the n distribution valves and used for conveying target water generated by the accelerator to a target water rotary bottle or a hot chamber; and at least one channel of the quantitative end 1-to-n distribution valve is connected with the injection assembly, and at least one channel is connected with the target water rotary bottle and is used for conveying the target water in the target water rotary bottle to an accelerator end 1-to-n distribution valve pipeline. Compared with the prior art, the target water quantitative distribution device for the liquid target of the cyclotron can realize directional and quantitative distribution of high-activity target water, greatly improve the use efficiency of high-value consumables such as a medical cyclotron and the target water, and overcome the problem that the high-activity target water can only be directionally (1-2 hot chambers) transmitted and cannot be automatically and quantitatively distributed in the prior art.)

1. A target water ration distributor for cyclotron liquid target which characterized in that: including accelerator end 1 lead to n distributing valve, ration end 1 lead to n distributing valve, injection subassembly, target aquatic commentaries on classics bottle, wherein:

the accelerator end 1 is connected with an accelerator through at least one channel of the n distribution valves and used for conveying target water generated by the accelerator to a target water rotary bottle or a hot chamber;

at least one channel of the quantitative end 1-to-n distribution valve is connected with the injection assembly, at least one channel is connected with the target water rotary bottle and is used for conveying the target water in the target water rotary bottle to an accelerator end 1-to-n distribution valve pipeline,

n is a natural number of 4 or more, and the number of hot chambers is not less than 2.

2. The target water quantitative distribution device for a cyclotron liquid target of claim 1, wherein: the injection assembly is connected to atmosphere via the dosing end 1 through at least one passage of the n-way dispensing valve.

3. The target water quantitative distribution device for a cyclotron liquid target according to claim 1 or 2, wherein: the injection assembly is a syringe pump.

4. The target water quantitative distribution device for a cyclotron liquid target of claim 3, wherein: the liquid outlet of the injection pump is fixedly connected with a public channel of the n distribution valves of the quantitative end 1.

5. The target water quantitative distribution device for a cyclotron liquid target according to claim 1 or 2, wherein: n is a natural number of 4 or more and 12 or less.

6. The target water quantitative distribution device for a cyclotron liquid target according to claim 1 or 2, wherein: the accelerator end 1 is connected with an accelerator through a public channel of the n distribution valves, one liquid outlet channel is connected with a target underwater rotary bottle, and at least two liquid outlet channels are used for connecting the hot chamber;

the public channel of the quantitative end 1 through n distribution valves is connected with the injection assembly, one channel is connected with the target underwater rotary bottle, and at least two channels are respectively connected with the hot chamber and the pipeline of the accelerator end 1 through n distribution valves through a tee joint.

7. The target water quantitative distribution device for a cyclotron liquid target of claim 6, wherein: the device also comprises an upper computer, wherein the upper computer is connected with the accelerator end 1 through n distribution valve, the quantitative end 1 through n distribution valve and the injection assembly through communication cables, and is used for the distance control and information feedback of the accelerator end 1 through n distribution valve, the quantitative end 1 through n distribution valve and the injection assembly.

8. The target water quantitative distribution device for a cyclotron liquid target according to claim 1 or 2, wherein: the quantitative end 1 leads to the n distribution valve and is used for connecting the pipeline of the target underwater rotary bottle and inserting the bottom of the target underwater rotary bottle.

Technical Field

The invention relates to the field of nuclear medicine and molecular imaging, and particularly provides a target water quantitative distribution device for a liquid target of a cyclotron, which is an automatic device for realizing quantitative and directional distribution of the liquid target water of the cyclotron to different hot chambers.

Background

PET/CT (Positron emission computed tomography/CT) utilizes an image fusion technology, integrates the advantages of PET functions, molecular metabolic images and CT fine anatomical images, combines the application of a plurality of molecular probes marked by Positron radioactive nuclide, has extremely important functions in the aspects of early diagnosis and tumor stage grading of malignant tumors, clinical efficacy evaluation and follow-up monitoring, benign and malignant lesion identification, assistance of clinical treatment scheme decision and radiotherapy target biological determination, exploration of tumor biological characteristics and the like, has unique value in the aspects of diagnosis, evaluation and the like of cardiovascular and cerebrovascular diseases, neurodegenerative diseases, epilepsy and the like, and is continuously increased in clinical application. The positron-emitting nuclides necessary for labeling various molecular probes are produced in two ways: nuclide generators (e.g., 68Ge-68Ga generators) and medical cyclotrons (e.g., to produce 18F, 11C, 13N, etc.). Compared with a nuclide generator, the medical cyclotron has the advantage of continuous and large-dose production, and particularly, some commercial high-energy medical cyclotrons can produce 18F ions with Curie at one time. However, compared with the generator, the cyclotron has higher operation cost in one start-up, more expensive conventional consumables (18 oxygen water), and more energy consumption cost in one start-up.

In 18F class positron medicine research and production processes, after being bombarded once by an accelerator, the medicines are generally transmitted to a corresponding synthesis hot chamber, and in most cases, only single and specific positron medicines can be synthesized. If synthesis is to be performed again, the accelerator can only be operated again for bombardment, which undoubtedly increases the operating cost of the accelerator and also increases the maintenance frequency of the equipment. For part of PET centers, a plurality of positron medicines need to be synthesized on the same day to meet the requirements of clinical examination, but the production of the positron medicines in the mode can only be carried out sequentially, so that the time period of medicine synthesis is increased undoubtedly. At present, commercial automatic equipment is not available temporarily, and high-activity target water after single bombardment can be distributed and transmitted. Most nuclear medicine chemists only distribute target water through an empirical switching flow path, and the repeatability and the standardization of the target water are insufficient, so that the production and the quality control of the radiopharmaceuticals are influenced.

Disclosure of Invention

The invention provides a target water quantitative distribution device for a liquid target of a cyclotron, which has a simple flow path and is accurately controlled, aiming at the defects in the prior art.

The technical scheme adopted by the invention for solving the technical problems is as follows: the utility model provides a target water ration distributor for cyclotron liquid target which characterized in that includes accelerator end 1 leads to n distributing valve, ration end 1 leads to n distributing valve, injection subassembly, target water rotary bottle, wherein: the accelerator end 1 is connected with an accelerator through at least one channel of the n distribution valves and used for conveying target water generated by the accelerator to a target water rotary bottle or a hot chamber; and at least one channel of the quantitative end 1-to-n distribution valve is connected with the injection assembly, and at least one channel is connected with the target water rotary bottle and is used for conveying the target water in the target water rotary bottle to an accelerator end 1-to-n distribution valve pipeline.

The distribution device combines a one-way n distribution valve with an injection assembly, and changes the direction of a liquid flow path through the one-way n distribution valve; the quantitative transfer of the high-activity target water is realized through the injection assembly, and finally the quantitative and directional distribution of the high-activity target water is realized through the combination of valve passage switching and injection assembly control. The process of quantitative distribution of target water by the distribution device comprises the following steps:

s1, conveying target water produced by a cyclotron to a target water rotary bottle or a hot chamber by matching an accelerator end 1 with an n distribution valve with the cyclotron;

s2, conveying target water produced by the cyclotron to a target water rotary bottle through an n distribution valve at the accelerator end 1, matching the quantitative distribution valve at the quantitative end 1 through the n distribution valve with an injection assembly, quantitatively absorbing the target water in the target water rotary bottle, and transferring the target water to a pipeline at the accelerator end 1 through the n distribution valve end;

and S3, transmitting the target water in the pipeline of the accelerator end 1 through the n distribution valves to the hot chamber by using He gas in the target water transmission system of the cyclotron.

Preferably, the number n of the distribution valve channels is a natural number of 4 or more, preferably 4 or more and 12 or less, for example, 4, 6, 9, 12 or the like. The number of the hot cells is not less than 2, preferably 3 to 10.

For example, when the number of channels n is 6, target water transport of 4 hot chambers at most can be achieved; when the number n of the channels is 9, the target water transmission of 7 hot chambers at most can be realized; when the number of channels n is 12, target water transfer of up to 10 hot chambers can be achieved.

Preferably, the injection assembly is also accessible to atmosphere via the dosing end 1 through at least one passage of the n-way dispensing valve. After the injection assembly can quantitatively suck target water in the rotary bottle in the target water, a proper amount of gas is sucked, so that the residual target water in the quantitative end 1 through n distribution valve is completely brought into a pipeline at the end of the accelerator end 1 through n distribution valve by the sucked gas.

Preferably, the injection assembly is a syringe pump, and the volume of the syringe pump can be 500uL, 1mL, 2.5mL or 5 mL.

Preferably, the liquid outlet of the injection pump is fixedly connected with the public channel of the quantitative end 1-way n-shaped distribution valve, so that the injection pump and the quantitative end 1-way n-shaped distribution valve are an inseparable whole and are used as an independent electric part for the device.

Preferably, the accelerator end 1 is connected with an accelerator through a public channel of the n distribution valves, one liquid outlet channel is connected with a target underwater rotary bottle, and at least two liquid outlet channels are used for connecting the hot chamber; the public channel of the quantitative end 1 through n distribution valves is connected with the injection assembly, one channel is connected with the target underwater rotary bottle, and at least two channels are respectively connected with the hot chamber and the pipeline of the accelerator end 1 through n distribution valves through a tee joint. In this way, He gas in the accelerator target water delivery system can be used to deliver the target water in the accelerator end 1 pipeline through the n-way distribution valve to the hot chamber.

Preferably, the target water quantitative distribution device for the liquid target of the cyclotron can further comprise an upper computer, wherein the upper computer is connected with the accelerator end 1 through n distribution valve, the quantitative end 1 through n distribution valve and the injection assembly through communication cables, and is used for the distance control and information feedback of the accelerator end 1 through n distribution valve, the quantitative end 1 through n distribution valve and the injection assembly (4).

Preferably, the distribution device can realize the following two working modes under the control of an upper computer:

mode one, the high activity target water is transferred entirely to a designated hot chamber.

And in the second mode, the high-activity target water is respectively conveyed to the specified hot chambers according to the specified distribution volume.

Compared with the prior art, the target water quantitative distribution device for the liquid target of the cyclotron has the following outstanding beneficial effects:

the invention fills the gap of the prior art, and the invention has no flow path control device specially used for quantitative and directional distribution of liquid target water of a medical cyclotron.

The high-activity target water obtained by the primary bombardment of the medical cyclotron can be packed into a plurality of parts by utilizing the equipment and respectively transmitted to different hot chambers, so that the conventional energy consumption of the medical cyclotron is reduced, the consumption of high-value consumables (oxygen 18 water) is reduced, and the running cost of the medical cyclotron can be greatly reduced.

The system can realize the quantitative and directional distribution function of target water, can realize the simultaneous preparation of different kinds of radiopharmaceuticals based on the same nuclide, greatly saves time cost and reduces ineffective nuclide attenuation effect.

The upper computer can feed back the running state of the equipment in real time, can check running parameters in real time in the running process, and improves the running stability of the equipment; meanwhile, the device operation data can be recorded and stored, and the traceability of the device operation is enhanced.

Drawings

FIG. 1 is a schematic structural view of a target water quantitative distribution device for a liquid target of a cyclotron according to an embodiment;

FIG. 2 is a schematic structural diagram of a target water quantitative distribution device for a liquid target of a cyclotron according to an embodiment.

The reference numerals in the drawings denote:

1. the device comprises a medical cyclotron, 2, an accelerator end 1-to-6 distribution valve, 3, a quantification end 1-to-6 distribution valve, 4, an injection pump, 5, a target water rotary bottle, 6, a hot chamber, 6.1, a hot chamber I, 6.2, a hot chamber II, 6.3, a hot chamber III, 7, a tee joint, 7.1, a tee joint I, 7.2, a tee joint II, 7.3, a tee joint III, 8 and an upper computer.

Detailed Description

The invention is further described with reference to the following figures and specific examples, which are not intended to be limiting.

In the present invention, the use of directional terms such as "upper, lower, left, right" generally means upper, lower, left, right as viewed with reference to the accompanying drawings, unless otherwise specified; "inner and outer" refer to the inner and outer relative to the profile of the components themselves.

The first embodiment is as follows:

as shown in fig. 1, the target water quantitative distribution device for a liquid target of a cyclotron of the present embodiment mainly comprises an accelerator end 1 through 6 distribution valve 2, a quantitative end 1 through 6 distribution valve 3, a syringe pump 4, a target water rotary bottle 5, and a tee joint 7.

The common channel of the accelerator end 1 through the 6 distribution valve 2 is connected with a target water transmission pipeline of the medical cyclotron 1; the channel 1 is connected with a target underwater rotary bottle 5 through a pipeline.

The public channel of the distribution valve 3 of the quantitative end 1 through 6 is connected with the injection pump 4; the pipeline of the channel 1 is connected with a target water rotary bottle 5, and the pipeline is inserted to the bottom of the target water rotary bottle 5.

The channel 2 of the accelerator end 1 through 6 distribution valve 2 is connected with the channel 2 of the quantitative end 1 through 6 distribution valve 3, and is connected with the first heat chamber 6.1 through a tee joint 7.1; the channel 3 of the distribution valve 2 at the accelerator end 1 is communicated with the channel 3 of the distribution valve 3 at the quantitative end 1 is communicated with the 6, and is connected with the second heating chamber 6.2 through a tee joint 7.2; the channel 4 of the accelerator end 1-to-6 distribution valve 2 is connected with the channel 4 of the quantitative end 1-to-6 distribution valve 3, and the heating chamber three 6.3 is connected through a tee joint 7.3.

The volume of the injection pump 4 is 2.5 mL; the medical cyclotron 1 is a GEMinitrace cyclotron, the target volume is 2.5mL, and 18F radioactive target water is obtained by bombarding 18 oxygen water. The dispensing device of the embodiment can adopt the following two modes to dispense and deliver the obtained high-activity target water.

Mode one the high activity target water is transferred entirely to a designated hot chamber.

Application scenarios: 2.2-2.5mL of 18F target water was transferred to a particular one of hot chamber one 6.1, hot chamber two 6.2, and hot chamber three 6.3.

Firstly, the accelerator end 1 is switched to the channel 2 through the 6-way distribution valve 2, the piston position of the injection pump 4 is reset to zero, the configuration of a transmission flow path to the first hot chamber 6.1 is completed, then the medical cyclotron 1 is operated, 18F-target water which is bombarded and completed is transmitted, and a button 'Drytoutlet' on a control interface of the medical cyclotron is clicked (blown out from a pipeline), so that 18F ions in the accelerator target body can be completely transmitted to the first hot chamber 6.1. The transmission to the second hot chamber 6.2 or the third hot chamber 6.3 is carried out in a similar way, only the channel of the distributing valve 2 of the accelerator end 1 through 6 is switched to the channel 3 or the channel 4 respectively, and other operations are the same.

Mode two high activity target water is delivered to a designated hot cell individually (or in batches of multiple deliveries from a particular hot cell) in a designated dispensed volume.

The application scene one: 2.2-2.5mL of 18F target water was transferred to hot chamber one 6.1, hot chamber two 6.2, and hot chamber three 6.3, respectively, according to specific volume amounts.

Firstly, the accelerator end 1 is switched to the channel 1 through the 6-way distribution valve 2, the medical cyclotron 1 is operated, and 2.2-2.5mL of high-activity target water is completely transferred to the target water rotary bottle 5. Then the quantitative end 1-to-6 distribution valve 3 is switched to the channel 1, 0.5mL of target water is sucked by the injection pump 4, then the quantitative end 1-to-6 distribution valve 3 is switched to the channel 2, the liquid in the injection pump 4 is pushed into the pipeline in full (the tee joint 7.1 is close to one side of the accelerator end 1-to-6 distribution valve 2), then the accelerator end 1-to-6 distribution valve 2 is switched to the No. 2 channel, and 0.5mL of target water is transported into the hot chamber I6.1 in full for standby by the He gas in the accelerator target water transport system. The method of dosing to other hot chambers is similar. Switching a quantitative end 1-to-6 distribution valve 3 to a channel 1, sucking 0.7mL of target water by using a syringe pump 4, switching the quantitative end 1-to-6 distribution valve 3 to the channel 3, injecting all liquid in the syringe pump 4 into a pipeline (a tee joint 7.2 is close to one side of the accelerator end 1-to-6 distribution valve 2), switching the accelerator end 1-to-6 distribution valve 2 to a No. 3 channel, and transmitting all 0.7mL of target water to a second hot chamber 6.2 for later use by using He gas in an accelerator target water transmission system; the quantitative end 1-to-6 distribution valve 3 is switched to the channel 1, 1.0mL of target water is sucked by the injection pump 4, then the quantitative end 1-to-6 distribution valve 3 is switched to the channel 4, the liquid in the channel 4 is pushed into the pipeline in a whole (the tee joint 7.3 is close to one side of the accelerator end 1-to-6 distribution valve 2), then the accelerator end 1-to-6 distribution valve 2 is switched to the channel No. 4, and 1.0mL of target water is transported into the hot chamber No. three 6.3 in a whole for standby by the He gas in the accelerator target water transport system.

Application scenario two: 2.2-2.5mL of 18F target water was dosed multiple times to the same hot chamber in specific volumetric amounts.

2.2-2.5mL of 18F target water was delivered to hot chamber one 6.1 in multiple batches according to a specified volume fraction. Firstly, the accelerator end 1 is switched to the channel 1 through the 6-way distribution valve 2, and the medical cyclotron 1 is operated to transfer 2.2-2.5mL of high-activity target water into the medium-activity target water rotary bottle 5. Then the quantitative end 1-to-6 distribution valve 3 is switched to the channel 1, 0.5mL of target water is sucked by the injection pump 4, then the quantitative end 1-to-6 distribution valve 3 is switched to the channel 2, the liquid in the injection pump 4 is pushed into the pipeline in full (the tee joint 7.1 is close to one side of the accelerator end 1-to-6 distribution valve 2), then the accelerator end 1-to-6 distribution valve 2 is switched to the No. 2 channel, and 0.5mL of target water is transported into the hot chamber one 6.1 in full by the He gas in the accelerator target water transport system. If the radioactivity is required to be transferred to the first heat chamber 6.1 again, the above process is repeated until the radioactivity transferred to the first heat chamber 6.1 meets the requirement.

Example two:

as shown in fig. 2, the target water quantitative distribution device for the cyclotron liquid target of the embodiment mainly comprises an accelerator end 1 through 6 distribution valve 2, a quantitative end 1 through 6 distribution valve 3, a syringe pump 4, a target water internal rotation bottle 5 and an upper computer 8.

The pipeline connection mode of the accelerator end 1 through 6 distribution valve 2, the quantitative end 1 through 6 distribution valve 3, the injection pump 4, the target underwater rotary bottle 5 and the tee joint 7 is the same as that of the first embodiment.

The dosing end 1 is vented 6 to atmosphere through the dispensing valve 3 6. The upper computer 8 is connected with the accelerator end 1 through 6 distribution valve 2, the quantitative end 1 through 6 distribution valve 3, the injection pump 4 and the tee joint 7 through communication cables.

When the dispensing device of the embodiment dispenses and transmits the obtained high-activity target water in the second mode, the quantitative end 1 is switched to the channel 1 through the 6 dispensing valve 3, 0.5mL of target water is sucked by the syringe pump 4, then the channel 6 is switched to suck air until the syringe pump is filled, then the quantitative end 1 is switched to the channel 6 through the 6 dispensing valve 3, and all liquid in the syringe pump 4 is injected into the pipeline (the tee joint 7.1 is close to one side of the accelerator end 1 through the 6 dispensing valve 2). Because the air sucked into the injection pump 4 is positioned above the target water, the target water in the injection pump 4 can be more thoroughly conveyed to the side of the three-way valve 7.1 close to the accelerator end 1-6 distribution valve 2 under the driving action of the air.