阅读说明：本技术 一种主动型药物溶解沉淀物获取装置 (Active drug dissolution precipitate acquisition device ) 是由 刘合义 陈英 于 2021-01-19 设计创作，主要内容包括：本发明涉及药物分析检测技术领域,特别涉及一种主动型药物溶解沉淀物获取装置,其中,搅拌装置包括固定座、转接球、动力端和搅拌棒；搅拌棒包括内管和外管,外管顶端贯穿转接球,使得外管与转接球相对于固定座的转动而同步转动,内管底端伸入溶解容器内；外管顶端与动力端通过球铰连接,并在动力端的驱动下在水平面内成圆形轨迹运动,外管顶端的旋转中心与转接球的旋转中心在同一条纵向轴线上；外管端部设置有腔体,腔体内设置有弹簧,内管伸入腔体对弹簧进行挤压。本发明中,搅拌过程更加均匀且稳定,当进行不同搅拌时间下沉淀物的测量时,可获得相对一致性的搅拌行为,在相对统一的标准下来建立搅拌时间与沉淀量之间的关系,保证测量的准确性。(The invention relates to the technical field of drug analysis and detection, in particular to an active drug dissolution precipitate acquisition device, wherein a stirring device comprises a fixed seat, a transfer ball, a power end and a stirring rod; the stirring rod comprises an inner tube and an outer tube, the top end of the outer tube penetrates through the transfer ball, so that the outer tube and the transfer ball rotate synchronously relative to the fixed seat, and the bottom end of the inner tube extends into the dissolving container; the top end of the outer pipe is connected with the power end through a spherical hinge and moves in a circular track in a horizontal plane under the driving of the power end, and the rotating center of the top end of the outer pipe and the rotating center of the transfer ball are on the same longitudinal axis; the outer pipe end is provided with a cavity, a spring is arranged in the cavity, and the inner pipe stretches into the cavity to extrude the spring. According to the invention, the stirring process is more uniform and stable, relatively consistent stirring behaviors can be obtained when sediment is measured under different stirring time, the relation between the stirring time and the sediment amount is established under relatively uniform standard, and the accuracy of measurement is ensured.)

1. An active drug dissolution precipitate retrieval device, comprising: a dissolving container (1), a stirring device (2) and a workbench (3);

the stirring device (2) comprises a fixed seat (21), a transfer ball (22), a power end (23) and a stirring rod (24); the stirring rod (24) comprises an inner tube (241) and an outer tube (242), the outer tube (242) is arranged at the top of the inner tube (241), the top end of the outer tube (242) is fixedly connected with the transfer ball (22), so that the outer tube (242) and the transfer ball (22) rotate synchronously relative to the rotation of the fixed seat (21), and the bottom end of the inner tube (241) extends into the dissolving container (1) for liquid stirring; the top end of the outer pipe (242) is connected with the power end (23) through a spherical hinge (244) and moves in a circular track in a horizontal plane under the driving of the power end (23), and the rotating center of the top end of the outer pipe (242) and the rotating center of the transfer ball (22) are on the same longitudinal axis;

the utility model discloses a dissolving container, including outer tube (242), inner tube (241), spring (243), inner tube (241) stretch into the cavity, and right spring (243) extrude, inner tube (241) with the tip of dissolving container (1) laminating is spherical structure.

2. The active drug dissolution precipitate retrieval device of claim 1, wherein the dissolution vessel (1) comprises an outer to inner bowl (11), a screen (12) and a shield (13); the inner surface and the outer surface of the bowl body (11) are concentric hemispheres, and the filter screen (12) is attached to at least the bottom of the inner surface of the bowl body (11) and can be separated from the bowl body; the cover (13) with the bowl body (11) rotate to be connected, have with the concentric hemisphere face's of bowl body (11) internal surface, and have at least and hold liquid and right filter screen (12) carry out the first operating position who shelters from, and pour liquid into in the bowl body (11) and right the second operating position that shelters from is carried out to the opening end of the bowl body (11).

3. The active drug dissolution precipitate retrieval device of claim 2, wherein the power end (23) comprises a guide rod (231), a slider (232), a first link (233), and a second link (234);

the guide rod (231) is fixedly arranged, the sliding block (232) slides along the guide rod (231), one end of the first connecting rod (233) is hinged to one end of the second connecting rod (234), the other end of the first connecting rod (233) is hinged to the guide rod (231), the other end of the second connecting rod (234) is hinged to the sliding block (232), the length of the second connecting rod (234) is larger than that of the first connecting rod (233), and the spherical hinge (244) is connected with the hinged position of the first connecting rod (233) and the second connecting rod (234).

4. The active drug dissolution precipitate retrieval device of claim 1, wherein the fixing base (21) comprises two clamping blocks horizontally symmetrically arranged at intervals, and the two clamping blocks are respectively attached to the transfer ball (22) through partial spherical surfaces.

5. The active drug dissolution precipitate acquisition device as claimed in claim 1 or 4, wherein the adapting ball (22) is provided with a through hole for the outer tube (242) to pass through, and the side wall of the through hole is provided with a through threaded hole, and the threaded hole is provided with an extrusion bolt (245) for extruding and fixing the outer tube (242).

6. The active drug dissolution precipitate acquisition device as claimed in claim 2, wherein the filter screen (12) comprises a net body and a frame (121), the net body is fixed by the frame (121), the frame (121) is attached to the inner wall of the bowl body (11), a stopper is locally arranged on the inner wall of the bowl body (11) for limiting the height of the frame (121), the frame (121) is retracted inwards relative to the edge of the bowl body (11), and the bowl body (11) is rotatably connected with the shielding cover (13) by a part higher than the frame (121).

7. The active drug dissolution precipitate retrieval device of claim 6, wherein the rim (121) is provided at an edge thereof with a protruding grip portion (122), and the bowl body (11) is provided at an edge thereof with a notch for the grip portion (122) to exit.

8. The active drug dissolution precipitate retrieval device of claim 7, wherein a gasket (14) is disposed at an edge of the bowl body (11), and the gasket (14) is attached to the shield cover (13).

9. The active drug dissolution precipitate retrieval device of claim 8, wherein the sealing collar (14) is attached to the rim (121).

Technical Field

The invention relates to the technical field of drug analysis and detection, in particular to an active drug dissolution precipitate acquisition device.

Background

Food medicine solubility is an important index that concerns medicine validity, and at present testing process, mostly at first wait to examine the medicine with the external world and pour into the cavity through dissolving the stirring mouth of cup inside, the manual work stirs the medicine in the cavity through external stirring rod, makes it dissolve can.

However, when manual stirring is performed, the stirring action of the stirring rod inevitably has differences along with the change of time, the stirring degree is extremely difficult to control, and when the accumulation amount of the sediment under different stirring time needs to be measured, the stirring action is changed and is difficult to control, so that the measuring accuracy is difficult to ensure.

In view of the above-mentioned existing defects, the present inventors have made extensive practical experience and professional knowledge for many years in designing and manufacturing such products, and have actively studied and innovated in cooperation with the application of theory, in order to create an active drug dissolution precipitate acquisition device, which is more practical.

Disclosure of Invention

The invention provides an active drug dissolved precipitate acquisition device, thereby effectively solving the problems in the background art.

In order to achieve the purpose, the invention adopts the technical scheme that:

an active drug dissolution precipitate retrieval device, comprising: a dissolving container, a stirring device and a workbench;

the stirring device comprises a fixed seat, a transfer ball, a power end and a stirring rod; the stirring rod comprises an inner tube and an outer tube, the outer tube is arranged at the top of the inner tube, the top end of the outer tube is fixedly connected with the switching ball, so that the outer tube and the switching ball rotate synchronously relative to the rotation of the fixed seat, and the bottom end of the inner tube extends into the dissolving container for liquid stirring; the top end of the outer pipe is connected with the power end through a spherical hinge and moves in a circular track in a horizontal plane under the driving of the power end, and the rotating center of the top end of the outer pipe and the rotating center of the transfer ball are on the same longitudinal axis;

the outer pipe tip is provided with the cavity, be provided with the spring in the cavity, the inner tube stretches into in the cavity, and right the spring extrudees, the inner tube with the tip of dissolving the container laminating is spherical structure.

Further, the dissolving container comprises a bowl body, a filter screen and a shielding cover from outside to inside; the inner surface and the outer surface of the bowl body are concentric hemispheres, and the filter screen is attached to at least the bottom of the inner surface of the bowl body and can be separated from the inner surface of the bowl body; the cover with the bowl body rotates to be connected, have with the internal surface of the concentric hemisphere face of the internal surface of bowl, and it is right to have at least and hold liquid the filter screen carries out the first operating position that shelters from, and pours liquid into in the bowl body and right the second operating position that shelters from is carried out to the opening end of the bowl body.

Further, the power end comprises a guide rod, a sliding block, a first connecting rod and a second connecting rod;

the guide bar is fixedly arranged, the sliding block slides along the guide bar, wherein one end of the first connecting rod is hinged to one end of the second connecting rod, the other end of the first connecting rod is hinged to the guide bar, the other end of the second connecting rod is hinged to the sliding block, the length of the second connecting rod is larger than that of the first connecting rod, and the spherical hinge is connected with the hinged position of the first connecting rod and the hinged position of the second connecting rod.

Furthermore, the fixing seat comprises two clamping blocks which are horizontally symmetrical and arranged at intervals, and the two clamping blocks are respectively attached to the switching ball through partial spherical surfaces.

Furthermore, a through hole for the outer pipe to penetrate through is formed in the transfer ball, a through threaded hole is formed in the side wall of the through hole, and an extrusion bolt is arranged in the threaded hole and used for extruding and fixing the outer pipe.

Further, the filter screen includes dictyosome and frame, the dictyosome passes through the frame is fixed, the frame with the laminating of the internal wall of bowl, just the part is provided with the dog on the inner wall of the bowl body, and is used for right the height of frame is restricted, the frame for the internal indent in bowl edge, the bowl body is through being higher than the part of frame with the shield cover rotates and is connected.

Furthermore, the edge of the frame is provided with a protruding holding part, and the edge of the bowl body is provided with a notch for leading out the holding part.

Further, the edge of the bowl body is provided with a sealing retainer ring, and the sealing retainer ring is attached to the shielding cover.

Further, the sealing retainer ring is attached to the frame.

Through the technical scheme of the invention, the following technical effects can be realized:

according to the invention, the stable rotation center of the stirring rod is obtained through the arrangement of the transfer ball, and a uniform circular stirring track is formed at the bottom of the stirring rod in the process of rotating around the rotation center, so that the whole stirring process is more uniform and stable, and when sediment is required to be measured under different stirring time, relatively consistent stirring behaviors can be obtained, so that the relation between the stirring time and the sediment amount can be established under relatively uniform standards, and the accuracy of measurement is ensured.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic view of the connection between the stirring device and the working platform of the active drug dissolution precipitate acquisition device of the present invention;

FIG. 2 is a schematic view of the manner of rotation of the stirring rod;

FIG. 3 is an enlarged view of a portion of FIG. 1 at A;

FIG. 4 is a schematic view of the structure of the dissolution vessel;

FIG. 5 is a schematic view showing the connection of the inner tube and the outer tube;

FIG. 6 is a partial cross-sectional view of a stir bar;

FIG. 7 is a cross-sectional view of a dissolution vessel;

FIG. 8 is an enlarged view of a portion of FIG. 7 at A (with the shutter cover in the first operating position);

FIG. 9 is a schematic view of the shield of FIG. 7 in a second operating position;

FIG. 10 is a schematic structural view of the power end;

FIG. 11 is an enlarged view of a portion of FIG. 1 at B;

FIG. 12 is a partial cross-sectional view of a screen;

FIG. 13 is an enlarged view of a portion of FIG. 4 at C;

reference numerals: 1. a dissolution vessel; 11. a bowl body; 12. filtering with a screen; 121. a frame; 122. a grip portion; 13. a shield cover; 14. a sealing retainer ring; 2. a stirring device; 21. a fixed seat; 22. transferring and receiving a ball; 23. a power end; 231. a guide bar; 232. a slider; 233. a first link; 234. a second link; 24. a stirring rod; 241. an inner tube; 242. an outer tube; 243. a spring; 244. spherical hinge; 245. extruding the bolt; 3. a work bench.

Detailed Description

The invention is further described below with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.

In the description of the present invention, it should be noted that the orientations or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like are based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; either directly or indirectly through intervening media, or may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art. This embodiment is written in a progressive manner.

As shown in fig. 1 to 7, an active drug dissolution precipitate acquisition device includes: a dissolving container 1, a stirring device 2 and a workbench 3; the stirring device 2 comprises a fixed seat 21, a switching ball 22, a power end 23 and a stirring rod 24; the stirring rod 24 comprises an inner tube 241 and an outer tube 242, the outer tube 242 is arranged on the top of the inner tube 241, the top end of the outer tube 242 is fixedly connected with the adapting ball 22, so that the outer tube 242 and the adapting ball 22 rotate synchronously relative to the rotation of the fixed seat 21, and the bottom end of the inner tube 241 extends into the dissolving container 1 for liquid stirring; the top end of the outer pipe 242 is connected with the power end 23 through a spherical hinge 244 and moves in a circular track in a horizontal plane under the driving of the power end 23, and the rotating center of the top end of the outer pipe 242 and the rotating center of the transfer ball 22 are on the same longitudinal axis; the end of the outer tube 242 is provided with a cavity, a spring 243 is arranged in the cavity, the inner tube 241 extends into the cavity and extrudes the spring 243, and the end of the inner tube 241 attached to the dissolving container 1 is of a spherical structure.

In the invention, the transfer ball 22 is arranged, so that the stirring rod 24 obtains a stable rotation center, and a uniform circular stirring track is formed at the bottom of the stirring rod 24 in the process of rotating around the rotation center, so that the whole stirring process is more uniform and stable, when sediment is required to be measured under different stirring time, relatively consistent stirring behaviors can be obtained, and thus, the relationship between the stirring time and the sediment amount can be established under relatively uniform standards, and the accuracy of measurement is ensured. When the stirring device is arranged, the center of the stirring ball and the center of the dissolving container 1 can be arranged up and down correspondingly; wherein, power end 23 is connected with outer tube 242, and outer tube 242 structure is stronger, can guarantee stable rotation, and inner tube 241 and the flexible setting of outer tube 242 elasticity can effectual laminating in dissolving container 1 bottom to guarantee to rolling of solid particulate matter, liquid accessible gravity in the cavity flows, can not cause the remaining of liquid.

As shown in fig. 7 to 9, the dissolving container 1 preferably includes a bowl 11, a strainer 12 and a shield 13; the inner surface and the outer surface of the bowl body 11 are concentric hemispheres, and the filter screen 12 is attached to at least the bottom of the inner surface of the bowl body 11 and can be separated from the inner surface and the outer surface; the shielding cover 13 is rotatably connected with the bowl body 11, has a hemispherical inner surface concentric with the inner surface of the bowl body 11, and at least has a first working position for containing liquid and shielding the filter screen 12, and a second working position for pouring the liquid into the bowl body 11 and shielding the open end of the bowl body 11.

In the stirring process, as shown in fig. 8, the shielding cover 13 is located at the first working position, so as to prevent the stirring device 2 from damaging the filter screen 12, and the shielding cover is attached to the stirring device 2; after the stirring is completed, as shown in fig. 9, the bowl body is rotated to a second working position, wherein the contained liquid flows into the bowl body 11, and the flowing-in action must be realized through the filter screen 12 in the rotating process of the shielding cover 13, and after the liquid is completely transferred, the shielding cover 13 is in the second working position to seal and protect the liquid, so as to avoid the influence of the external environment on the liquid; after standing, when there is an undissolved portion, which remains on the screen 12, the amount of undissolved residue can be determined by removing the screen 12 and weighing it.

According to the invention, through the control of the stirring track, the stable support of the bowl body 11 and the multi-level arrangement, the uniformity of the stirring process can be improved, the stirred liquid is directly poured into the filter screen 12 at the bottom through the shielding cover 13 for filtering, the time for the residual liquid on the inner wall of the shielding cover 13 to enter the filter screen 12 can be ensured in the static process, the liquid is poured into the filter structure with better accuracy after the stirring is finished, and the filter screen 12 is slowly removed after the liquid is static on the filter screen 12, so that the undissolved medicine can be effectively filtered, and the possibility that solid particles pass through the filter screen 12 is reduced for the pouring mode with impact, and the detection accuracy is effectively ensured.

As a preference of the above embodiment, the power end 23 includes a guide rod 231, a slider 232, a first link 233, and a second link 234; the guide rod 231 is fixedly arranged, the sliding block 232 slides along the guide rod 231, wherein one end of the first connecting rod 233 is hinged with one end of the second connecting rod 234, the other end of the first connecting rod 233 is hinged with the guide rod 231, the other end of the second connecting rod 234 is hinged with the sliding block 232, the length of the second connecting rod 234 is larger than that of the first connecting rod 233, and the spherical hinge 244 is connected with the hinged position of the first connecting rod 233 and the second connecting rod 234.

As shown in fig. 10 and 11, during operation, the second link 234 is moved and rotated by the slider 232 relative to the guide bar 231, so that the first link 233 is rotated around the set point by one end of the first link 233. Therefore, in the process of stirring, only by manually applying force to the first link 233 or the slider 232, it can be ensured that the position of the ball hinge 244 connected to the hinge position of the first link 233 and the second link 234 obtains a stable rotation track, and the uniformity of the stirring action is ensured. In the process of stirring, compared with the control of the rotary motion, the manual active motion is limited to the linear motion of the sliding block 232 or the motion of the second connecting rod 234 under the limitation of the sliding block 232 and the first connecting rod 233, so that the stable control is more easily obtained, and the difficulty of the operation is reduced.

Preferably, the fixing base 21 includes two clamping blocks horizontally and symmetrically arranged at intervals, and the two clamping blocks are respectively attached to the adapting ball 22 through partial spherical surfaces. Wherein, the distance between two clamp splice is the setting value, and the two accessible transition piece or direct connection to guarantee the convenience of installation.

The switching ball 22 is provided with a through hole for the outer tube 242 to pass through, a through threaded hole is formed in a side wall of the through hole, and an extrusion bolt 245 is arranged in the threaded hole to extrude and fix the outer tube 242. As shown in fig. 3, by controlling the degree of pressing of the pressing bolt 245, the quick adjustment of the height of the outer pipe 242 can be achieved.

Preferably, the filter screen 12 includes a net body and a frame 121, the net body is fixed by the frame 121, the frame 121 is attached to the inner wall of the bowl 11, a stopper is partially disposed on the inner wall of the bowl 11 for limiting the height of the frame 121, the frame 121 is retracted inward relative to the edge of the bowl 11, and the bowl 11 is rotatably connected to the shielding cover 13 by a portion higher than the frame 121. The edge of the frame 121 is provided with a protruding holding portion 122, and the edge of the bowl body 11 is provided with a notch for leading out the holding portion 122.

Referring to fig. 12 and 13, in the stirring process, the net body is protected by the shielding cover 13 to avoid damage caused by the stirring device 2, and the frame 121 can conveniently drive the net body to enter and exit the bowl body 11 through the change of the position of the shielding cover 13, so that the whole dissolving container 1 is convenient to clean and maintain, and the rotation of the shielding cover 13 can realize the liquid pouring, thereby achieving the purpose of filtering through the filter screen 12.

In the above embodiment, the rim of the bowl 11 is preferably provided with the gasket 14, and the gasket 14 is preferably attached to the shield cover 13. By means of the sealing collar 14, the gap between the bowl 11 and the shield 13 is effectively sealed, in particular, contamination during standstill is avoided. Preferably the gasket 14 is removable for cleaning. Wherein, the sealing retainer ring 14 is preferably attached to the frame 121, so as to ensure the stability of the position of the frame 121. As a preference of the above embodiment, the sealing retainer ring 14 is attached to the frame 121, so as to ensure the stability of the position of the frame 121.

The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.