阅读说明：本技术 自动同时过程控制 (Automatic simultaneous process control ) 是由 P·施万 H·勃兰特 M·罗贝丹 S-O·博尔谢特 N·韦伯 于 2020-02-19 设计创作，主要内容包括：本文描述了一种用于自动同时控制连续生产过程的至少两个过程特性的方法和系统,所述连续生产过程具有至少一个流体流、至少两个单元操作、至少一个过程控制系统和至少一个调节体积。(A method and system for automatically simultaneously controlling at least two process characteristics of a continuous production process having at least one fluid stream, at least two unit operations, at least one process control system, and at least one regulated volume is described herein.)

1. Method for automatically simultaneously controlling at least two process characteristics of a continuous production process having at least one fluid flow, at least two unit operations, at least one process control system and at least one regulated volume, the method comprising at least one of:

a) at least one subsystem for automatically controlling at least two actuators affecting the same adjustment volume,

and/or the presence of a gas in the gas,

b) at least one subsystem for automatically affecting at least one actuator based on a combination of feed-forward regulation and feedback control.

2. The method of claim 1, wherein

a) If the method according to claim 1 comprises at least one subsystem for automatically controlling at least two actuators affecting the same adjustment volume, the at least one subsystem for automatically controlling at least two actuators affecting the same adjustment volume controls at least two process characteristics via:

simultaneously detecting at least two characteristics of the fluid flow via at least two independent sensors,

calculating at least two actuation values, one for each of at least two measured characteristics in at least one process control system,

influencing at least two actuators via the at least two actuation values,

and/or the presence of a gas in the gas,

b) if the method according to claim 1 comprises at least one subsystem for automatically influencing at least one actuator based on a combination of feed-forward regulation and feedback control, the at least one subsystem for automatically influencing the at least one actuator based on a combination of feed-forward regulation and feedback control influences at least one process characteristic via:

using at least one sensor to detect at least one characteristic of at least one conditioning volume located upstream of one of the at least two unit operations,

detecting at least one characteristic related to the loading of one of the at least two unit operations,

calculating at least one actuation value of at least one process control system, the calculation being based on the detected at least one characteristic of at least one adjustment volume located upstream of one of the at least two unit operations and on at least one characteristic related to the loading of one of the at least two unit operations,

influencing at least one actuator via the at least one actuation value,

wherein said influence of the actuator is thus based on a combination of a feed forward adjustment derived from at least one detected characteristic related to the loading of one of said at least two unit operations and a feedback control derived from at least one detected characteristic of at least one adjustment volume.

3. Method according to claim 1 or 2, wherein the method according to claim 1 or 2 comprises at least one subsystem for automatically controlling at least two actuators affecting the same adjustment volume, the method a) further comprising the steps of:

transmitting the at least two characteristics of the fluid flow detected by the at least two independent sensors as signals to at least two converters which convert the signals into converted signals, and

transmitting the at least two converted signals to at least one process control system.

4. Method according to claim 3, wherein method a) comprises at least one subsystem for automatically controlling at least two actuators affecting the same adjustment volume, method a) further comprising the steps of:

comparing the at least two converted signals corresponding to at least two actual process characteristics with at least two set points of the same process characteristic in at least one process control system,

calculating at least two actuation values of the process control system based on the comparison and the additional calculation.

5. The method according to any one of claims 1 to 4, comprising at least two subsystems.

6. A system for automatically controlling at least two process characteristics of a fluid flow of a continuous production process having at least two unit operations, at least one process control system and at least one regulated volume, the system comprising at least one of:

a) at least one subsystem for simultaneous automatic control of at least two actuators affecting the same adjustment volume, the subsystem comprising at least two independent sensors simultaneously detecting at least two characteristics of the fluid flow and at least one process control system calculating at least two actuation values based on the at least two characteristics of the fluid flow, each of the at least two actuation values corresponding to each of at least two measured characteristics affecting at least two actuators,

and/or

b) At least one subsystem for automatically influencing at least one actuator based on a combination of feed-forward regulation and feedback control, the subsystem comprising at least one regulation volume located upstream of at least two unit operations, at least one sensor having a characteristic for the at least one regulation volume and at least one sensor for loading the at least one unit operation and at least one actuator influencing the at least one unit operation.

7. The system of claim 6, further comprising at least one subsystem for matching the flow rate of a slave unit to the flow rate of other slave units or master units, provided that the auxiliary flow is turned on in case of multiple master units, and comprising:

at least one master unit and at least one slave unit, wherein each slave unit affects at least one buffer volume, wherein each buffer volume is provided in the form of a buffer tank and/or an expandable tube, and at least one sensor for each buffer volume.

8. The system of claim 6, wherein at least one subsystem for simultaneously automatically controlling at least two actuators affecting the same regulated volume further comprises at least two transducers to which at least two independent sensors transmit the at least two characteristics of fluid flow in the form of at least two signals, the transducers then converting the at least two signals and transmitting at least two converted signals to at least one process control system.

9. The system of claim 6, wherein the continuous production process is a continuous production process of biomolecules.

10. The system of claim 6, wherein the fluid flow is a continuous fluid flow.

11. The system of claim 6, wherein at least two characteristics of the fluid flow and at least one characteristic of at least one conditioning volume are controlled automatically and simultaneously.

12. The system of claim 6, wherein one of the at least two unit operations is chromatography and the process control system employs a soft sensor.