阅读说明：本技术 气泡检测方法、电子设备、可读存储介质及血泵系统 (Bubble detection method, electronic device, readable storage medium and blood pump system ) 是由 韩佳鑫 宋合 易博 罗七一 于 2020-03-31 设计创作，主要内容包括：本发明提供一种血泵回路气泡检测方法、电子设备、可读存储介质及血泵系统,包括：获取实时监测的血泵泵头出口处的超声信号衰减值和流体流量值；利用关于所述超声信号衰减值和所述流体流量值的函数,分别计算从气泡开始时刻到气泡消失时刻的时间区间内多个气泡的体积表征值；将各所述气泡的体积表征值进行累加,以得到所述时间区间内的总气泡体积表征值。如此,便通过定量计算气泡体积的方法解决了介入式磁力离心血泵的泵头将气泡打散后利用现有技术难以对血泵回路气泡进行准确检测的问题。(The invention provides a blood pump loop bubble detection method, electronic equipment, a readable storage medium and a blood pump system, which comprise the following steps: acquiring an ultrasonic signal attenuation value and a fluid flow value at the outlet of a pump head of a blood pump which are monitored in real time; respectively calculating volume characterization values of a plurality of bubbles in a time interval from a bubble start time to a bubble disappearance time by using functions related to the ultrasonic signal attenuation value and the fluid flow value; and accumulating the volume characterization values of the bubbles to obtain a total bubble volume characterization value in the time interval. Therefore, the problem that accurate detection of bubbles in a blood pump loop is difficult to carry out by utilizing the prior art after bubbles are scattered by the pump head of the intervention type magnetic centrifugal blood pump is solved by a method for quantitatively calculating the volume of the bubbles.)

1. A blood pump loop bubble detection method is characterized by comprising the following steps:

acquiring an ultrasonic signal attenuation value and a fluid flow value at the outlet of a pump head of a blood pump which are monitored in real time;

respectively calculating volume characterization values of a plurality of bubbles in a time interval from a bubble start time to a bubble disappearance time by using functions related to the ultrasonic signal attenuation value and the fluid flow value;

and accumulating the volume characterization values to obtain a total bubble volume characterization value in the time interval.

2. The blood pump circuit bubble detection method of claim 1, wherein the blood pump circuit bubble detection method comprises:

and judging the bubble starting time and the bubble disappearing time according to the size relation between the ultrasonic signal attenuation value and a normal value, wherein the normal value is the ultrasonic signal attenuation value detected when no bubble exists.

3. The blood pump circuit bubble detection method according to claim 2, wherein the method for determining the bubble start time and the bubble disappearance time according to the magnitude relationship between the ultrasonic signal attenuation value and the normal value comprises:

if the attenuation value of the ultrasonic signal is increased to a first multiple of the normal value, judging that the current moment is the bubble starting moment;

and if the ultrasonic signal attenuation value continuously falls back to within the second multiple of the normal value for multiple times from the bubble starting time, judging that the current time is the bubble ending time.

4. The blood pump circuit bubble detection method of claim 2, wherein prior to detecting the ultrasound signal attenuation value, the blood pump circuit bubble detection method comprises:

calibrating the ultrasound signal attenuation value to the normal value; and the number of the first and second groups,

initializing bubble detection parameters including the total bubble volume characterization value, the ultrasonic signal attenuation value, and the fluid flow value.

5. The blood pump circuit bubble detection method of claim 1, wherein after obtaining the total bubble volume characterization value, the blood pump circuit bubble detection method comprises:

and judging whether to send out a warning signal and/or judging whether to make a pump stopping response according to the total bubble volume characterization value, wherein the warning signal comprises an alarm signal and an early warning signal.

6. The blood pump circuit bubble detection method of claim 5, wherein the method for determining whether to send out an alarm signal and/or determining whether to make a pump stopping response according to the total bubble volume representation value comprises:

if the volume characterization value of the total bubbles is greater than or equal to a first preset value, sending an alarm signal and stopping the blood pump from running;

if the volume characterization value of the total bubbles is greater than or equal to a second preset value, an early warning signal is sent, but the blood pump is not stopped to operate.

7. The blood pump circuit bubble detection method of claim 1, wherein in calculating the total bubble volume characterization value, the following formula is used:

wherein Q is the total bubble volume characterization value, t_startIs the bubble start time, t_endAs the moment of disappearance of the bubble, D_iFor the attenuation value, v, of the ultrasonic signal_iFor the fluid flow value, k is a proportionality coefficient and is related to the fluid viscosity.

8. An electronic device comprising a processor and a memory, the memory having stored thereon a computer program which, when executed by the processor, implements the method of any of claims 1 to 7.

9. A readable storage medium, in which a computer program is stored which, when executed, implements the method of any one of claims 1 to 7.

10. A blood pump system, comprising: the device comprises a blood pump, a blood pump pipeline, an ultrasonic sensor and control equipment; wherein the content of the first and second substances,

the blood pump pipeline is in fluid communication with the blood pump, and the ultrasonic sensor is arranged on the blood pump pipeline at the outlet of the pump head of the blood pump;

the ultrasonic sensor comprises an ultrasonic transmitting device and an ultrasonic receiving device, the ultrasonic receiving device comprises a flow monitoring unit and a bubble detecting unit, the flow monitoring unit is used for detecting a fluid flow value, and the bubble detecting unit is used for detecting an ultrasonic signal attenuation value;

the control device is respectively connected with the blood pump and the ultrasonic sensor in a communication mode and used for controlling the blood pump according to signals of the ultrasonic sensor, and the control device comprises the electronic device as claimed in claim 8.

Technical Field

The invention relates to the technical field of medical instruments, in particular to a blood pump loop bubble detection method, electronic equipment, a readable storage medium and a blood pump system.

Background

The intervention type magnetic centrifugal blood pump is used for establishing a blood circulation channel in vitro and assisting the heart in pumping blood. The detachable intervention type magnetic centrifugal blood pump consists of a consumable part and a non-consumable part. The consumable part is called a pump head system and comprises 3 parts of a centrifugal pump head, a venous trans-septal cannula and an arterial cannula. The non-consumable part is called a pump base system and comprises a centrifugal pump base, a controller, a treatment trolley and the like. The centrifugal pump head of the extracorporeal pump is used for doing work on blood and pumping the blood into the whole body. The impeller of the pump is internally provided with driven magnetic steel, and the motor of the base transmits torque to the impeller through a magnetic coupling structure consisting of the driving magnetic steel and the driven magnetic steel. The transvenous septal cannula, which contains a cannula and dilator, is implanted from the femoral vein, punctures through the interatrial septum, enters the left atrium from the right atrium and draws blood from the left atrium. The arterial cannula, which contains a cannula and dilator, is implanted from the femoral artery and pumps blood into the descending aorta. The circumstances such as blood pipeline connection is not tight, puncture syringe needle is not hard up, the tiny damage of pipeline can cause the air to get into blood pipeline, forms the bubble, and simultaneously, the negative pressure that the blood pump rotation caused also can make dissolved bubble in the blood separate out from the blood once more. When air bubbles enter the body, air emboli can form, and in the worst case, can lead to death of the patient. Therefore, it is very important to provide an effective bubble detecting means for improving the safety of the product.

The ultrasonic wave is a mechanical wave with vibration frequency higher than that of sound wave, and the transduction chip is produced by vibration under the stimulation of voltage, and has the features of high frequency, short wavelength and less diffraction. In particular, the characteristics of good directivity and directional propagation enable the antenna to be widely applied in many fields. In automatically controlled medical electronic equipment such as dialysis, transfusion and the like, ultrasonic waves are commonly used for monitoring whether air and bubbles are mixed in a pipeline; in order to ensure the safety of patients, the prior infusion pump generally comprises a bubble detection function, and the bubble volume is indirectly measured and an alarm is given out by adopting an ultrasonic scattering attenuation principle.

For the intervention type magnetic centrifugal blood pump, a pump head which runs at a high speed can easily break up a complete bubble into a plurality of even a series of micro bubbles, and the bubble detection device/method is directly applied to find that the bubble detection rate is greatly reduced because the generated micro bubbles cannot be distinguished due to cavitation or air entering along with the occurrence of the bubble breaking-up phenomenon, thereby increasing the use risk of the product.

Disclosure of Invention

The invention aims to provide a blood pump loop bubble detection method, electronic equipment, a readable storage medium and a blood pump system, so as to solve the problem that accurate detection of blood pump loop bubbles is difficult by using the prior art.

In order to solve the technical problem, the invention provides a blood pump loop bubble detection method, which comprises the following steps:

acquiring an ultrasonic signal attenuation value and a fluid flow value at the outlet of a pump head of a blood pump which are monitored in real time;

respectively calculating volume characterization values of a plurality of bubbles in a time interval from a bubble start time to a bubble disappearance time by using functions related to the ultrasonic signal attenuation value and the fluid flow value;

and accumulating the volume characterization values to obtain a total bubble volume characterization value in the time interval.

Optionally, in the blood pump circuit bubble detection method, the blood pump circuit bubble detection method includes:

and judging the bubble starting time and the bubble disappearing time according to the size relation between the ultrasonic signal attenuation value and a normal value, wherein the normal value is the ultrasonic signal attenuation value detected when no bubble exists.

Optionally, in the method for detecting bubbles in a blood pump circuit, the method for determining the bubble start time and the bubble disappearance time according to the magnitude relationship between the ultrasonic signal attenuation value and the normal value includes:

if the attenuation value of the ultrasonic signal is increased to a first multiple of the normal value, judging that the current moment is the bubble starting moment;

and if the ultrasonic signal attenuation value continuously falls back to within the second multiple of the normal value for multiple times from the bubble starting time, judging that the current time is the bubble ending time.

Optionally, in the blood pump circuit bubble detection method, before detecting the ultrasound signal attenuation value, the blood pump circuit bubble detection method includes:

calibrating the ultrasound signal attenuation value to the normal value; and the number of the first and second groups,

initializing bubble detection parameters including the total bubble volume characterization value, the ultrasonic signal attenuation value, and the fluid flow value.

Optionally, in the blood pump circuit bubble detection method, after obtaining the total bubble volume characterization value, the blood pump circuit bubble detection method includes:

and judging whether to send out a warning signal and/or judging whether to make a pump stopping response according to the total bubble volume characterization value, wherein the warning signal comprises an alarm signal and an early warning signal.

Optionally, in the blood pump circuit bubble detection method, the method for determining whether to send an alarm signal and/or determine whether to make a pump stop response according to the total bubble volume characterization value includes:

if the volume characterization value of the total bubbles is greater than or equal to a first preset value, sending an alarm signal and stopping the blood pump from running;

if the volume characterization value of the total bubbles is greater than or equal to a second preset value, an early warning signal is sent, but the blood pump is not stopped to operate.

Optionally, in the blood pump circuit bubble detection method, when the total bubble volume characterization value is calculated, the following formula is adopted:

wherein Q is the total bubble volume characterization value, t_startFor the bubblesStarting time, t_endAs the moment of disappearance of the bubble, D_iFor the attenuation value, v, of the ultrasonic signal_iFor the fluid flow value, k is a proportionality coefficient and is related to the fluid viscosity.

Based on the same idea, the present invention further provides an electronic device, comprising a processor and a memory, wherein the memory stores a computer program, and the computer program implements the method as described above when being executed by the processor.

Based on the same idea, the present invention further provides a readable storage medium, in which a computer program is stored, and when the computer program is executed, the method as described above is implemented.

Based on the same idea, the invention also provides a blood pump system, comprising: the device comprises a blood pump, a blood pump pipeline, an ultrasonic sensor and control equipment; wherein the content of the first and second substances,

the blood pump pipeline is in fluid communication with the blood pump, and the ultrasonic sensor is arranged on the blood pump pipeline at the outlet of the pump head of the blood pump;

the ultrasonic sensor comprises an ultrasonic transmitting device and an ultrasonic receiving device, the ultrasonic receiving device comprises a flow monitoring unit and a bubble detecting unit, the flow monitoring unit is used for detecting a fluid flow value, and the bubble detecting unit is used for detecting an ultrasonic signal attenuation value; the control device is respectively in communication connection with the blood pump and the ultrasonic sensor and is used for controlling the blood pump according to signals of the ultrasonic sensor, and the control device comprises the electronic device.

The blood pump loop bubble detection method, the electronic device, the readable storage medium and the blood pump system provided by the invention comprise the following steps: acquiring an ultrasonic signal attenuation value and a fluid flow value at the outlet of a pump head of a blood pump which are monitored in real time; respectively calculating volume characterization values of a plurality of bubbles in a time interval from the bubble starting moment to the bubble disappearing moment by using functions related to the ultrasonic signal attenuation value and the fluid flow value; and accumulating the volume values of the bubbles to obtain a total volume characterization value of the total bubbles in the time interval. Therefore, the problem that accurate detection of bubbles in a blood pump loop is difficult to carry out by utilizing the prior art after bubbles are scattered by the pump head of the intervention type magnetic centrifugal blood pump is solved by a method for quantitatively calculating the volume of the bubbles.

Drawings

FIG. 1 is a flow chart of a blood pump circuit bubble detection method provided by an embodiment of the present invention;

FIG. 2 is a schematic view of the operation of the blood pump in the embodiment of the present invention;

fig. 3 is a view showing a configuration of an ultrasonic sensor according to an embodiment of the present invention;

FIG. 4 is a diagram of an experimental apparatus for analyzing output characteristics of an ultrasonic sensor after bubbles are broken up according to an embodiment of the present invention;

FIG. 5 is a graph comparing the attenuation of ultrasonic signals without bubbles and with broken bubbles in an embodiment of the present invention;

FIG. 6 is a graph comparing attenuation of ultrasonic signals after different amounts of bubbles are input at a constant flow rate according to an embodiment of the present invention;

FIG. 7 is a graph comparing attenuation of ultrasonic signals at different flow rates for a given bubble volume in an embodiment of the present invention;

fig. 8 is a specific flowchart of an exemplary blood pump circuit bubble detection method according to an embodiment of the present invention.

Detailed Description

The blood pump circuit bubble detection method, the electronic device, the readable storage medium and the blood pump system according to the present invention will be described in further detail with reference to the accompanying drawings and specific embodiments. The advantages and features of the present invention will become more apparent from the following description. It is to be noted that the drawings are in a very simplified form and are not to precise scale, which is merely for the purpose of facilitating and distinctly claiming the embodiments of the present invention. Further, the structures illustrated in the drawings are often part of actual structures. In particular, the drawings may have different emphasis points and may sometimes be scaled differently.

As mentioned above, although the prior art can indirectly measure the volume of bubbles by using the ultrasonic scattering attenuation principle, for an interventional magnetic centrifugal blood pump, a pump head operating at a high speed can easily break up a complete bubble into a plurality of even a series of micro bubbles, and direct application of the prior art bubble detection device/method can find that the bubble detection rate is greatly reduced along with the occurrence of the bubble breaking-up phenomenon, thereby increasing the use risk of the product.

In view of this, as shown in fig. 1, an embodiment of the present invention provides a blood pump circuit bubble detection method, including the following steps:

s1, acquiring an ultrasonic signal attenuation value and a fluid flow value at the outlet of the pump head of the blood pump monitored in real time;

s2, respectively calculating the volume characterization values of a plurality of bubbles in a time interval from the bubble starting moment to the bubble disappearing moment by using the function of the ultrasonic signal attenuation value and the fluid flow value;

and S3, accumulating the volume characteristic values of the bubbles to obtain a total bubble volume characteristic value in the time interval.

As can be seen from the above steps, the method for detecting bubbles in a blood pump circuit provided in this embodiment solves the problem that it is difficult to estimate the original bubble volume and distinguish the original bubble volume from microbubbles generated by cavitation phenomenon after the complete bubbles in the blood pump circuit are scattered by the method for quantitatively calculating the bubble volume, that is, solves the problem that it is difficult to accurately detect bubbles in the blood pump circuit by using the prior art.

The above steps will be described in detail below.

In step S1, the ultrasonic signal attenuation value and the fluid flow rate value may be detected by an ultrasonic sensor, and specifically, as shown in fig. 2, the ultrasonic sensor may be used as a part of a pump base system of an interventional magnetic centrifugal blood pump, and the ultrasonic sensor may be clamped at an outlet of a pump head of the interventional magnetic centrifugal blood pump to detect the ultrasonic signal attenuation value.

As shown in fig. 3, it is a schematic view of an ultrasonic sensor, which integrates ultrasonic transmission and reception and mainly consists of an ultrasonic transmitter and an ultrasonic receiver.

The ultrasonic transmitter has a piezoelectric ceramic ultrasonic probe, and the ultrasonic signal is obtained by converting an alternating electric signal by a piezoelectric effect. The device mainly relates to a transmitting signal generating circuit. The signal generating circuit generates a suitable alternating electrical signal, typically a sine wave signal. The signal is amplified and matched with a certain amplitude of power by the driving circuit, and then can be transmitted by the transmitting probe.

The ultrasonic receiving device comprises a flow monitoring unit and a bubble detection unit, wherein the flow monitoring unit is used for detecting a fluid flow value, the bubble detection unit is used for detecting an ultrasonic signal attenuation value, and the fluid flow value and the ultrasonic signal attenuation value can be detected simultaneously through the flow monitoring unit and the bubble detection unit; the flow monitoring unit comprises a receiving probe, a processing circuit and a data processing unit. Processing circuits corresponding to different measurement methods (time difference method, phase difference method, doppler method, etc.) are different, and generally include circuits such as a small-signal amplification circuit, a filter circuit, and demodulation conversion. The signal is operated and processed by the data processing unit to obtain the fluid flow. The bubble detection unit consists of a receiving probe, a transducer, a signal amplification circuit and an AD acquisition module. The transducer can detect the bubbles in the flow channel by measuring the penetration energy of the ultrasonic waves. When no air exists in the pipe, the ultrasonic waves emitted by the emitting device penetrate through the pipe wall and the fluid to reach the transducer, the received sound energy is converted into a voltage signal, the energy attenuation is small, and the received sound energy is strong; conversely, the received signal is weaker. When the bubbles are more or air embolism occurs, most energy of the ultrasonic wave is reflected, and the ultrasonic energy received by the transducer is nearly zero. The transducer thus estimates the bubble volume and transmits the processing results to the controller via the transmission module. In order to ensure the accuracy of signal transmission, the signal can be further amplified by the signal amplifying circuit and then output, and the AD acquisition module is used for converting the analog signal output by the signal amplifying circuit into a digital signal.

The power supply interface can be powered by the controller in a wired mode or a battery mode; the communication interface with the controller can adopt a wireless or wired mode.

If the existing bubble detection means is directly applied to the centrifugal blood pump loop, a separate bubble detection device needs to be added, so that the cost is increased. When the blood pump loop bubble detection method provided by the embodiment is realized, if the ultrasonic sensor is adopted, the detection of bubbles can be completed while the flow is detected, namely, the ultrasonic sensor can be adopted to integrate the flow and the bubble detection, so that the use requirement is well met, and the complexity of product design and the product cost are reduced.

For the human body, when the dose of the air embolism is inputted to a certain degree, the body is discomforted and even life danger is caused. After the bubbles are scattered, the original bubble diameter alarm threshold value cannot be reached, broken bubbles enter a human body without generating alarm information, and safety accidents are easy to happen. After the bubbles are scattered, if the alarm threshold value of the bubble diameter is reduced, the false alarm is easily generated due to the microbubbles or noise generated by the cavitation phenomenon, and the operation process is also influenced.

For this reason, in step S2, the bubbles generated by cavitation can be prevented from interfering with the detection of the original bubbles by quantitative estimation of the volume of the bubbles.

In order to quantitatively estimate the volume of the bubbles, researchers of the invention design an experimental scheme to analyze the output characteristics of the ultrasonic sensor after the bubbles are scattered, and an experimental device is shown in figure 4 and is provided with a tee joint for injecting the bubbles; the air bubbles are scattered by the rotor when passing through the centrifugal pump; the ultrasonic sensor detects the attenuation of the broken bubbles to ultrasonic signals at the outlet of the pump head; and a Personal Computer (PC) is connected with the sensor through a serial port and reads the attenuation amount of the ultrasonic signal detected by the ultrasonic sensor. The following phenomena 1 to 5 are summarized in the experimental process.

Phenomenon 1: when the blood flow of the blood pump is below 300mL/min, the bubbles adhere to the wall and do not move along the blood flow direction; when the blood flow of the blood pump is more than 300mL/min, air bubbles move along the tube wall and enter the pump head.

Phenomenon 2: because the pump head rotor is running at high speed, air bubbles, especially large air bubbles, entering the pump head can be broken up into a plurality of broken air bubbles by the rotor blades. Broken bubbles can be gathered at the top of the pump head, and only when the blood flow is more than 500mL/min (the experimental value under certain conditions, actually, the value is different due to different parameters such as blood viscosity and the like), the broken bubbles can flow out of the blood pump and enter the arterial cannula, so that the operation safety is influenced.

Phenomenon 3: when no bubble exists, the attenuation of the ultrasonic signal is stably kept at a lower value; when broken bubbles exist, the attenuation amount of the ultrasonic signal is obviously increased. As shown in fig. 5, the attenuation of the ultrasonic signal output by the sensor after the bubble of 5m is broken up is obviously increased and is distributed discretely. In fig. 5, the abscissa indicates the number of continuous monitoring within a certain time, and the ordinate indicates the attenuation amount of the ultrasonic signal.

Phenomenon 4: at the same flow rate, the size of the bubble directly affects the output value of the ultrasonic signal attenuation amount, and meanwhile, the duration is also affected. The output characteristics after inputting different amounts of bubbles at a flow rate of 2.0L/min are shown in fig. 6, the abscissa represents the monitoring times, and the ordinate represents the ultrasonic signal attenuation amount, and experiments show that the larger the bubble is, the larger the ultrasonic signal attenuation amount output by the ultrasonic sensor is, and at the same time, the duration of the output attenuation amount higher than a normal value (the ultrasonic signal attenuation amount without the bubble) is obviously increased.

Phenomenon 5: with the same size of bubble, the flow rate will also have a large effect on the sensor output signal. As shown in fig. 7, the output characteristics of the medium-amount bubbles at different flow rates are shown in fig. 7, where the abscissa represents the number of monitoring times and the ordinate represents the attenuation amount of the ultrasonic signal, and according to experiments, it is found that the larger the flow rate is, the larger the attenuation amount of the ultrasonic signal output by the ultrasonic sensor is.

By combining the phenomena, the total volume of the bubbles is positively correlated with the attenuation amount of the ultrasonic signal output by the ultrasonic sensor, positively correlated with the duration time of the bubbles and negatively correlated with the flow rate value of the fluid.

Therefore, in step S2, the bubble volume indicator Qi at a certain time is defined as the attenuation D of the sensor output signal_iAnd a fluid flow value v_iAs a function of (c). Namely, it is

Q_i＝f(D_i,v_i)

The total bubble volume characteristic value can be obtained by adding the volume characteristic values of a plurality of bubbles in continuous time periods, namely

Wherein, t_startRefers to the bubble start time, t_endRefers to the bubble ending time.

In actual operation, the bubble start time and the bubble disappearance time may be determined according to a magnitude relationship between the ultrasonic signal attenuation value and a normal value, where the normal value is an ultrasonic signal attenuation value detected when no bubble exists, and the determination method may be as follows: if the attenuation value of the ultrasonic signal is increased to a first multiple of the normal value, judging that the current moment is the bubble starting moment; and if the ultrasonic signal attenuation value continuously falls back to within the second multiple of the normal value for multiple times from the bubble starting time, judging that the current time is the bubble ending time.

That is, t_startIn actual operation, the attenuation value of the bubble signal output by the ultrasonic sensor is higher than the normal value without bubbles by a certain range, t_endIn actual operation, the time point is when the attenuation value of the bubble signal output by the ultrasonic sensor falls back within a certain range of the normal value continuously detected for the Nth time after the bubble detection is started.

Preferably, the specific form of the f-function can be obtained by performing function fitting according to a large amount of experimental data accumulated in the test environment shown in fig. 3, for example: q_i＝k×D_i/v_iK is a proportionality coefficient and is related to the viscosity of the fluid, the fluids with different viscosities correspond to different K values, for the blood pump circuit, the K value is the viscosity of blood, for different human bodies, the K value has a certain difference, the K value can be usually detected by common medical means such as blood routine examination, and a doctor can set the K value in a computer system according to the result of the blood routine examination so as to calculate the bubble volume characterization value.

When the above formula Q is adopted_i＝k×D_i/v_iWhen a specific form of the f function is defined, correspondingly, the calculation formula of the total bubble volume characterization value is as follows:

further, the blood pump circuit bubble detection method provided by this embodiment further includes: and judging whether to send out a warning signal and/or to make a pump stopping response according to the total bubble volume characterization value, wherein the warning signal can comprise an alarm signal, an early warning signal and the like. Specifically, if the volume characterization value of the total bubbles is greater than or equal to a first preset value, an alarm signal is sent out, and the blood pump is stopped to run; if the volume characterization value of the total bubbles is greater than or equal to a second preset value, an early warning signal is sent, but the blood pump is not stopped to operate. The first preset value and the second preset value may be set according to actual requirements, for example, a volume value of bubbles harmful to a human body may be defined as the first preset value, and a volume value of bubbles risking the human body may be defined as the second preset value, but the first preset value and the second preset value may also be set differently depending on different subjects, such as an adult and a child, or a severe patient and a mild patient.

For a normal adult, for example, the first preset value may be defined as 50ml and the second preset value as 10 ml. When the accumulation reaches equivalent 50ml and above, indicating that the human body is seriously harmed, an alarm signal is sent out, and the alarm signal can be embodied in a form of sound and vision. When the accumulation reaches equivalent 10ml and above bubbles, a certain risk is indicated, so that an early warning signal is sent out, and the early warning signal can be embodied in a visual form to be distinguished from the alarm signal.

Preferably, before detecting the attenuation value of the ultrasonic signal, the blood pump circuit bubble detection method provided by this embodiment further includes: calibrating the ultrasound signal attenuation value to the normal value; and initializing bubble detection parameters, including setting Q to 0, i to 1, refreshing parameters D, v, and so on.

The blood pump circuit bubble detection method provided in this embodiment is exemplified by referring to fig. 5, wherein if the attenuation value of the ultrasonic signal continuously drops within 1.5 times of the normal value for 8 times, it is determined that the current time is the bubble end time.

The first step is as follows: performing startup calibration, and determining the ultrasonic attenuation P under normal conditions;

the second step is that: initializing relevant parameters of bubble detection: q, i, D, v;

the third step: judging whether the current ultrasonic signal attenuation D is larger than 2P (namely setting the first multiple to be 2 times);

if greater than 2P, according to the formula:

calculating a current Q value;

if the value is less than 2P, returning to the second step;

the fourth step: judging the bubble amount according to the current Q value, and if Q is less than 1ml, not performing any treatment; if Q is more than 1ml, but Q is less than 5ml, alarming for detecting micro bubbles and stopping the operation of the pump; if Q is more than 5ml, alarming for detecting a large amount of bubbles and stopping the operation of the pump; and finally returning to the second step to restart a round of bubble detection.

The fifth step: a refresh parameter D, v, which is used for judging whether the current ultrasonic signal attenuation D is less than 1.5P (i.e. the second multiple is set to be 1.5 times), if so, adding 1 to i, and returning to the fourth step when i is greater than 8, otherwise, returning to the third step; and if the D is not less than 1.5P, returning to the third step.

It should be noted that, as shown in fig. 8, the first preset value is defined as 50ml, and the second preset value is defined as 10ml for example. However, it should be understood that, in actual operation, before the detection is started, a doctor can adjust the first preset value and the second preset value accordingly according to objective factors such as different subjects to be used and actual physical conditions of the subjects to be used, and specific settings of the first preset value and the second preset value should not constitute limitations on the blood pump circuit bubble detection method provided by the present embodiment.

From the above description of the embodiments, it is clear to those skilled in the art that the present invention can be implemented by software plus necessary general hardware platform. Based on such understanding, some features of the technical solutions of the present invention that essentially or contribute to the prior art may be embodied in the form of a computer program, which may be stored in a readable storage medium, such as ROM/RAM, a magnetic disk, an optical disk, and the like. Therefore, an embodiment of the present invention further provides an electronic device, where the electronic device includes a processor and a memory, where the memory stores a computer program, and the computer program, when executed by the processor, implements the method according to the embodiment or some parts of the embodiment of the present invention. Furthermore, the embodiment of the present invention also provides a readable storage medium, in which a computer program is stored, and when the computer program is executed by a processor, the method according to the embodiment or some parts of the embodiment is performed.

In addition, the present embodiment also provides a blood pump system, including: a blood pump, a blood pump pipeline, a control device and the ultrasonic sensor described in the embodiment; wherein the blood pump pipeline is in fluid communication with the blood pump, and the ultrasonic sensor is arranged on the blood pump pipeline at the outlet of the pump head of the blood pump; the control device is in communication connection with the blood pump and the ultrasonic sensor respectively, and is configured to control the blood pump according to a signal from the ultrasonic sensor, where the control device includes the electronic device according to this embodiment, and the control device may be, for example, the PC terminal in the foregoing section.

In summary, the blood pump circuit bubble detection method, the electronic device, the readable storage medium and the blood pump system provided by the embodiment of the invention have the following beneficial effects:

(1) aiming at the difficulty of bubble detection in the field, namely the fact that bubbles are scattered by blades of a centrifugal pump under high flow, an effective method for quantitatively estimating the volume of the bubbles is provided, and the problems that the original volume of the bubbles is difficult to estimate by a single means after the bubbles are scattered completely and the bubbles generated by cavitation phenomenon are difficult to distinguish are solved;

(2) the bubble detection function is added into a ventricular assist product, so that the operation safety is improved; meanwhile, a sensor integrating flow detection and bubble detection is adopted, so that the use requirement is well met, and the complexity of product design and the product cost are reduced;

(3) according to the total bubble volume characterization value, two-stage alarming is carried out and different treatment measures are correspondingly carried out, so that the operation safety is improved;

(4) when the machine is initialized (at the moment, the blood pump is not started, the pipeline is filled with blood but has no bubbles), the ultrasonic signal attenuation value acquired by the sensor is automatically analyzed, the ultrasonic signal attenuation value at the moment is set as a normal value, zero point offset when different sensors or the same sensor measure the ultrasonic signal attenuation value at different moments is avoided, and the timeliness and the accuracy of bubble detection are improved.

The above description is only for the purpose of describing the preferred embodiments of the present invention, and is not intended to limit the scope of the present invention, and any variations and modifications made by those skilled in the art based on the above disclosure are within the scope of the appended claims.