阅读说明：本技术 饲料用肠溶性氧化锌及其生产方法 (Enteric zinc oxide for feed and production method thereof ) 是由 沈代秀 于 2021-01-26 设计创作，主要内容包括：本发公开了一种饲料用肠溶性氧化锌的生产方法,生产原料包括粒状氧化锌和肠溶包被层材料,所述粒状氧化锌与肠溶包被层材料中固含物的质量比为1:0.05～0.2；所述粒状氧化锌的生产原料包括氧化锌粉和辅料。其优点是：能够明显提高断奶仔猪对氧化锌饲料添加剂的利用率。(The invention discloses a production method of enteric-coated zinc oxide for feed, which comprises the following production raw materials of granular zinc oxide and an enteric-coated layer material, wherein the mass ratio of the granular zinc oxide to solid in the enteric-coated layer material is 1: 0.05-0.2; the production raw materials of the granular zinc oxide comprise zinc oxide powder and auxiliary materials. The advantages are that: can obviously improve the utilization rate of the zinc oxide feed additive for the weaned piglets.)

1. The production method of the enteric zinc oxide for the feed is characterized by comprising the following steps: the production raw materials comprise granular zinc oxide and an enteric coating layer material, wherein the mass ratio of the granular zinc oxide to solid in the enteric coating layer material is 1: 0.05-0.2; the production raw materials of the granular zinc oxide comprise zinc oxide powder and auxiliary materials.

2. The method for producing enteric zinc oxide for feed according to claim 1, characterized in that: the enteric coating layer material comprises the following components in parts by mass: 10 parts of phthalic acid cellulose acetate, 2-4 parts of propyl gallate, 5-11 parts of polypropylene resin, 2-6 parts of talcum powder, 3-6 parts of diethyl phthalate and 80-110 parts of ethanol.

3. The method for producing enteric zinc oxide for feed according to claim 1, characterized in that: the auxiliary materials comprise starch, a disintegrating agent and a binder.

4. The method for producing enteric zinc oxide for feed according to claim 3, characterized in that: the disintegrating agent is microcrystalline cellulose, and the binder is dextrin.

5. The method for producing enteric zinc oxide for feed according to claim 1, characterized in that: the zinc oxide powder is nano-scale zinc oxide powder.

6. The method for producing enteric zinc oxide for feed according to claim 2, characterized by comprising the steps of:

s1, adding the zinc oxide powder and auxiliary materials into a pill making machine to prepare granular zinc oxide;

s2, mixing the phthalic acid cellulose acetate, propyl gallate, polypropylene resin, talcum powder, diethyl phthalate and ethanol in proportion to prepare a coating agent, and injecting the coating agent into a coating machine;

and S3, adding the granular zinc oxide into a coating machine, starting the coating machine, and discharging to obtain the zinc oxide coated paper.

7. Enteric zinc oxide for feed produced by the method for producing enteric zinc oxide for feed according to any one of claims 1 to 7.

8. A method for producing a piglet feed, characterized in that a raw material for production comprises the enteric zinc oxide for feed according to claim 7.

9. The piglet feed produced by the method for producing the piglet feed according to claim 8.

10. A piglet feeding method, which is characterized in that: comprising the step of adding the enteric zinc oxide for feed according to claim 7 to a piglet diet.

Technical Field

The invention relates to a feed additive production technology, in particular to a production technology of a zinc oxide additive for feed.

Background

Zinc is a trace element necessary for maintaining normal physiological functions and biochemical metabolism of humans and animals, and is called a "vital element" because it has a wide range of physiological functions in the body. Zinc is a component of more than 40 metalloenzymes in the body, and more than 200 enzymes are activating factors and participate in nucleic acid and protein synthesis, energy metabolism, redox, cellular immunity and humoral immunity processes. In addition, zinc has been reported to have the effects of promoting the rapid regeneration of taste bud cells of tongue mucosa and enhancing appetite. The zinc oxide is added into the daily feed for the early weaned piglets, so that the diarrhea of the piglets can be reduced, the daily gain can be increased, and the feed efficiency can be improved. Although high zinc plays a great role in preventing diarrhea of weaned piglets, the addition amount of zinc in the feed of the current feed manufacturer is more than 20 times of the normal requirement of animals, and reaches 3000-4000 g/t of feed, which leads to a series of problems in the long-term past. After animals are fed with the high-copper high-zinc daily ration, copper and zinc are easily enriched in the liver, the kidney and the muscle, and direct harm is brought to the health of people and livestock. Research shows that when piglets are fed with daily ration containing high-dose zinc oxide (3000mg/kg), the zinc content in excretory feces of the piglets is remarkably higher than that of a normal zinc dose group, and the daily zinc discharge amount of the high-dose zinc group is 33 times that of a basal daily ration group. The pig manure containing high-concentration copper and zinc does not meet the requirement of agricultural sustainable development, and meanwhile, the pig manure brings heavy burden to the environment.

In order to solve the problems, researchers have invented enteric-coated zinc oxide, and the scheme is that an enteric-coated material is adopted to coat the surface of zinc oxide particles, and the characteristic of segmented release of the enteric-coated material is utilized, so that the zinc oxide can be effectively protected from being neutralized by gastric acid, the coating material can be decomposed when the zinc oxide reaches the intestinal tract, and the zinc oxide is naturally released; the enteric zinc oxide can replace common zinc oxide, the use of the zinc oxide is reduced, the addition level of the zinc oxide in the daily ration of the weaned pig can be effectively reduced, and the irreversible pollution of the residual zinc in the pig manure to the soil is reduced.

However, the currently marketed enteric zinc oxide still has disadvantages, for example, CN101803684A mentions that zinc oxide is coated with an enteric material, and the damage of gastric acid to zinc oxide can be overcome due to the coating material, but the coating method has a problem of difficult release in intestinal fluid; CN102125171A also has similar problems with intestinal fluid release as described above; CN102318750A is through adopting the coating submicron order zinc oxide, and cubic shielding agent handles zinc oxide and can make the coating have fine tolerance to gastric acid, and has certain improvement to intestinal absorption, but release zinc oxide still has the defect in the intestines, and current technique still can not solve zinc oxide high efficiency and utilize and environmental protection pollution problem completely, meets the obstacle in the popularization in the market. The reason for this may be that although the enteric coating layer can be dissolved in the intestinal tract, the intestinal tract of the weaned piglet is not developed perfectly and is in the adaptation stage of transition from liquid food to solid food, and the weight of the intestinal tract of the piglet is only 3-5% of the weight, the coating layer made of the enteric material cannot have a proper dissolving time in the intestinal tract of the piglet, and the characteristics of the intestinal tract of the piglet lead to that the piglet cannot absorb the zinc oxide coated by the coating well, and part of the zinc oxide is easily discharged along with the feces of the piglet, so that the utilization rate of the piglet feed is negatively affected.

Disclosure of Invention

The invention provides enteric-coated zinc oxide for feed and a production method thereof, which aim to improve the utilization rate of a zinc oxide feed additive for piglets.

The technical scheme adopted by the invention is as follows: the production method of the enteric-coated zinc oxide for the feed comprises the following production raw materials of granular zinc oxide and an enteric-coated layer material, wherein the mass ratio of the granular zinc oxide to solid in the enteric-coated layer material is 1: 0.05-0.2; the production raw materials of the granular zinc oxide comprise zinc oxide powder and auxiliary materials.

As a further improvement of the invention, the enteric coating layer material is composed of the following components in parts by mass: 10 parts of phthalic acid cellulose acetate, 2-4 parts of propyl gallate, 5-11 parts of polypropylene resin, 2-6 parts of talcum powder, 3-6 parts of diethyl phthalate and 80-110 parts of ethanol.

As a further improvement of the invention, the auxiliary materials comprise starch, a disintegrating agent and a binder. More preferably, the disintegrating agent is microcrystalline cellulose, and the binder is dextrin.

As a further improvement of the invention, the zinc oxide powder is nano-scale zinc oxide powder.

The production method of the enteric zinc oxide for the feed can be implemented according to the following steps:

s1, adding the zinc oxide powder and auxiliary materials into a pill making machine to prepare granular zinc oxide;

s2, mixing the phthalic acid cellulose acetate, propyl gallate, polypropylene resin, talcum powder, diethyl phthalate and ethanol in proportion to prepare a coating agent, and injecting the coating agent into a coating machine;

and S3, adding the granular zinc oxide into a coating machine, starting the coating machine, and discharging to obtain the zinc oxide coated paper.

The invention also discloses enteric-coated zinc oxide for feed, which is prepared by the production method of the enteric-coated zinc oxide for feed.

The invention also discloses a production method of the piglet feed, which is characterized in that the production raw materials comprise the enteric-coated zinc oxide for the feed.

The invention also discloses a piglet feed which is prepared by the production method of the piglet feed.

The invention also discloses a piglet feeding method which is characterized by comprising the step of adding the enteric-coated zinc oxide for the feed into piglet daily ration.

The invention has the beneficial effects that: can obviously improve the utilization rate of the zinc oxide feed additive for the weaned piglets.

Detailed Description

The present invention will be further described with reference to the following examples.

The first embodiment is as follows:

enteric zinc oxide for feed is prepared according to the following method:

(1) the enteric coating layer material consists of the following components in parts by mass: 10 parts of phthalic acid cellulose acetate, 3 parts of propyl gallate, 7 parts of polypropylene resin, 4 parts of talcum powder, 5 parts of diethyl phthalate and 100 parts of ethanol;

the production raw material of the granular zinc oxide consists of the following components in parts by mass: 30 parts of nano-grade zinc oxide powder, 4 parts of starch, 2 parts of dextrin and 6 parts of microcrystalline cellulose.

(2) Adding water into the nanoscale zinc oxide powder, starch, dextrin and microcrystalline cellulose, uniformly stirring, putting into a hopper of a wet mixing shot blasting machine, extruding materials by a low-temperature extruder at the rotating speed of 40rpm and the aperture of 0.42mm, rounding zinc oxide particles by a rounding machine with the diameter of a rolling disc of 1000mm at the rotating speed of 600r/min, metering and packaging after production, and packaging 40kg of granular zinc oxide per package.

(3) Taking the phthalic acid cellulose acetate, propyl gallate, polypropylene resin, talcum powder, diethyl phthalate and ethanol, firstly dissolving the polypropylene resin in the ethanol, then adding other raw materials, stirring uniformly, and injecting into a rotational flow fluidization granulation coating machine.

(4) Preparing production raw materials according to the mass ratio of 1:0.1 of the granular zinc oxide to the solid content in the enteric coating layer material, putting the granular zinc oxide into the rotational flow fluidization granulation coating machine, coating at the air speed of 50MHZ, the air inlet temperature of 52 ℃ and the air outlet temperature of 34 ℃, wherein the coating time is 7.5 hours per batch, and immediately packaging and sealing by using a vacuum bag after production is finished and metering to obtain the enteric zinc oxide for the feed.

Example two:

enteric zinc oxide for feed is prepared according to the following method:

(1) the enteric coating layer material consists of the following components in parts by mass: 10 parts of phthalic acid cellulose acetate, 2 parts of propyl gallate, 5 parts of polypropylene resin, 2 parts of talcum powder, 3 parts of diethyl phthalate and 95 parts of ethanol;

the production raw material of the granular zinc oxide consists of the following components in parts by mass: 30 parts of nano-grade zinc oxide powder, 4.5 parts of starch, 3 parts of dextrin and 5.5 parts of microcrystalline cellulose.

(2) Adding water into the nanoscale zinc oxide powder, starch, dextrin and microcrystalline cellulose, uniformly stirring, putting into a hopper of a wet mixing shot blasting machine, extruding materials by a low-temperature extruder at the rotating speed of 40rpm and the aperture of 0.42mm, rounding zinc oxide particles by a rounding machine with the diameter of a rolling disc of 1000mm at the rotating speed of 600r/min, metering and packaging after production, and packaging 40kg of granular zinc oxide per package.

(3) Taking the phthalic acid cellulose acetate, propyl gallate, polypropylene resin, talcum powder, diethyl phthalate and ethanol, firstly dissolving the polypropylene resin in the ethanol, then adding other raw materials, stirring uniformly, and injecting into a rotational flow fluidization granulation coating machine.

(4) Preparing production raw materials according to the mass ratio of 1:0.12 of the granular zinc oxide to the solid content in the enteric coating layer material, putting the granular zinc oxide into the rotational flow fluidization granulation coating machine, coating at the air speed of 50MHZ, the air inlet temperature of 52 ℃ and the air outlet temperature of 34 ℃, wherein the coating time is 7.5 hours per batch, and immediately packaging and sealing by using a vacuum bag after production is finished and metering to obtain the enteric zinc oxide for the feed.

Example three:

enteric zinc oxide for feed is prepared according to the following method:

(1) the enteric coating layer material consists of the following components in parts by mass: 10 parts of phthalic acid cellulose acetate, 4 parts of propyl gallate, 8 parts of polypropylene resin, 5 parts of talcum powder, 3 parts of diethyl phthalate and 100 parts of ethanol;

the production raw material of the granular zinc oxide consists of the following components in parts by mass: 30 parts of nano-grade zinc oxide powder, 5 parts of starch, 3 parts of dextrin and 6 parts of microcrystalline cellulose.

(2) Adding water into the nanoscale zinc oxide powder, starch, dextrin and microcrystalline cellulose, uniformly stirring, putting into a hopper of a wet mixing shot blasting machine, extruding materials by a low-temperature extruder at the rotating speed of 40rpm and the aperture of 0.42mm, rounding zinc oxide particles by a rounding machine with the diameter of a rolling disc of 1000mm at the rotating speed of 600r/min, metering and packaging after production, and packaging 40kg of granular zinc oxide per package.

(3) Taking the phthalic acid cellulose acetate, propyl gallate, polypropylene resin, talcum powder, diethyl phthalate and ethanol, firstly dissolving the polypropylene resin in the ethanol, then adding other raw materials, stirring uniformly, and injecting into a rotational flow fluidization granulation coating machine.

(4) Preparing production raw materials according to the mass ratio of 1:0.13 of the granular zinc oxide to the solid content in the enteric coating layer material, putting the granular zinc oxide into the rotational flow fluidization granulation coating machine, coating at the air speed of 50MHZ, the air inlet temperature of 52 ℃ and the air outlet temperature of 34 ℃, wherein the coating time is 7.5 hours per batch, and immediately packaging and sealing by using a vacuum bag after production is finished and metering to obtain the enteric zinc oxide for the feed.

Comparative example one:

common zinc oxide feed additive.

Comparative example two:

this comparative example is a control of example one, following exactly the same procedure and conditions as example one, except that: the enteric coating layer material does not contain propyl gallate. The specific implementation steps are as follows:

(1) the enteric coating layer material consists of the following components in parts by mass: 10 parts of phthalic acid cellulose acetate, 7 parts of polypropylene resin, 4 parts of talcum powder, 5 parts of diethyl phthalate and 100 parts of ethanol;

the production raw material of the granular zinc oxide consists of the following components in parts by mass: 30 parts of nano-grade zinc oxide powder, 4 parts of starch, 2 parts of dextrin and 6 parts of microcrystalline cellulose.

(2) Adding water into the nanoscale zinc oxide powder, starch, dextrin and microcrystalline cellulose, uniformly stirring, putting into a hopper of a wet mixing shot blasting machine, extruding materials by a low-temperature extruder at the rotating speed of 40rpm and the aperture of 0.42mm, rounding zinc oxide particles by a rounding machine with the diameter of a rolling disc of 1000mm at the rotating speed of 600r/min, metering and packaging after production, and packaging 40kg of granular zinc oxide per package.

(3) Taking the phthalic acid cellulose acetate, propyl gallate, polypropylene resin, talcum powder, diethyl phthalate and ethanol, firstly dissolving the polypropylene resin in the ethanol, then adding other raw materials, stirring uniformly, and injecting into a rotational flow fluidization granulation coating machine.

(4) Preparing production raw materials according to the mass ratio of 1:0.1 of the granular zinc oxide to the solid content in the enteric coating layer material, putting the granular zinc oxide into the rotational flow fluidization granulation coating machine, coating at the air speed of 50MHZ, the air inlet temperature of 52 ℃ and the air outlet temperature of 34 ℃, wherein the coating time is 7.5 hours per batch, and immediately packaging and sealing by using a vacuum bag after production is finished and metering to obtain the enteric zinc oxide for the feed.

Feeding experiment:

feeding a subject: the number of 21-day-old weaned piglets is 200, and the piglets are randomly divided into 5 groups of an experimental group 1, an experimental group 2, an experimental group 3, a control group 1 and a control group 2, and each group has 40 piglets.

Experiment time: and 15 days.

Feeding management: the feed formula of each group is identical except that the zinc oxide is added, and the other components are identical (the same piglet basic ration is used, and the components comprise 60.15% of corn, 10% of whey powder, 20.0% of soybean meal, 5.0% of fish meal, 2% of cane sugar, 1% of calcium hydrophosphate, 0.55% of stone powder, 0.3% of salt and 1% of piglet premix). Wherein:

the experimental group 1 is characterized in that the enteric zinc oxide prepared in the first embodiment is added into daily ration, and the addition amount is 400 g/ton;

the experiment group 2 adds the enteric zinc oxide prepared in the second embodiment into daily ration, and the addition amount is 400 g/ton;

in the experimental group 3, the enteric zinc oxide prepared in the third example was added to the daily ration in an amount of 400 g/ton; the control group 1 added the common zinc oxide feed additive of the first comparative example in the daily ration, and the addition amount was 2500 g/ton;

the control group 2 is added with the enteric zinc oxide prepared in the second comparative example in daily ration, and the addition amount is 400 g/ton;

during the experiment, the special person is responsible for raising, the environmental conditions are kept consistent, the people can freely eat and drink water, the conventional immunization and disinfection are carried out, and the colony house is kept clean and sanitary.

And (3) detecting the zinc content of the piglet manure:

sampling the feces of each piglet on the same day on the 5 th day, the 10 th day and the 15 th day after the beginning of feeding to detect the zinc content, wherein the specific detection method of each sample is as follows:

A. drying the excrement sample, mashing the dried excrement sample, weighing the dried excrement sample, placing the dried excrement sample for one day, and weighing the dried excrement sample again until the mass difference between the two times is less than 1 g.

B. Taking 2g of the dried sample, placing the sample in a crucible, treating the sample at 550 ℃ for 3 hours, then measuring 10mL of prepared 1:3 hydrochloric acid by using a measuring cylinder, adding the hydrochloric acid into the crucible to dissolve ash, then placing the crucible on an electric furnace to heat, stopping heating when the liquid is left to be 2-3 mL, filtering the liquid by using filter paper into a 50mL volumetric flask, fixing the volume by using distilled water, and filtering the solution by using a 0.22 mu m filter membrane into a glass bottle to be detected.

C. The zinc element content of a sample to be measured is measured by adopting an inductively coupled plasma spectrum generator, the relative standard deviation between 2 times of measurement results of each sample is counted and calculated, the data when the relative standard deviation is less than 5 percent is recorded, each group of data is sorted and then is subjected to mean value list analysis, and the result is shown in table 1.

TABLE 1 Table of the results of the zinc content test of the piglet feces

As can be seen from the table 1, the addition of the enteric-coated zinc oxide for feed of the invention into the daily ration of weaned pigs can obviously improve the absorption and utilization rate of the piglets on the zinc oxide. And the detection results of the experimental group 1 and the control group 2 show that the content of zinc element in the excrement of the piglets can be obviously reduced by adding a proper amount of propyl gallate in the enteric coating layer material, which indicates that the absorption and utilization rate of the zinc element of the piglets is obviously improved, and the method is probably related to that the propyl gallate can change the dissolving time of the coating layer which takes the phthalic acid cellulose acetate as the main enteric material in the intestines and stomach of the piglets.