阅读说明：本技术 柔性电子器件硬脑膜下植入的辅助装置 (Auxiliary device for subdural implantation of flexible electronic device ) 是由 黄显 李亚 刘松 周盼 刘忻羽 凌伟 陈兆润 于 2020-12-31 设计创作，主要内容包括：本公开提供了一种柔性电子器件硬脑膜下植入的辅助装置,包括：柱芯、负压单元和注射单元。至少一个待植入柔性电子器件与柱芯的第一端相连,注射单元与所述柱芯的第二端相连。注射单元嵌设在所述负压单元内,且注射单元与负压单元一体连接。本公开利用负压吸引抓取并提起硬脑膜,增大了硬脑膜与大脑皮层的间距,极大地增加了器件在硬脑膜下的植入空间,更加便于器件的植入。(The present disclosure provides an auxiliary device for subdural implantation of a flexible electronic device, comprising: the device comprises a column core, a negative pressure unit and an injection unit. At least one flexible electronic device to be implanted is connected to a first end of the core and an injection unit is connected to a second end of the core. The injection unit is embedded in the negative pressure unit and is integrally connected with the negative pressure unit. The dura mater is grabbed and lifted by utilizing the negative pressure attraction, the distance between the dura mater and the cerebral cortex is increased, the implantation space of the device under the dura mater is greatly increased, and the device is more conveniently implanted.)

1. An assistive device for subdural implantation of a flexible electronic device, comprising:

at least one flexible electronic device to be implanted connected to the first end of the core;

a negative pressure unit adsorbed on the surface of the dura mater;

the injection unit is connected with the second end of the column core, is embedded in the negative pressure unit and is integrally connected with the negative pressure unit;

the negative pressure unit generates negative pressure, the negative pressure unit attracts and grabs the surface of the dura mater, and a space is generated between the surface of the dura mater and the cerebral cortex; the injection unit pushes the column core to enable the flexible electronic device to be implanted between the dura mater and the cerebral cortex.

2. The assist device according to claim 1, wherein the negative pressure unit includes:

the negative pressure suction nozzle is sleeved at the end part of the first end of the negative pressure cavity;

the negative pressure piston is connected with the second end of the negative pressure cavity;

and the negative pressure suction cup is sleeved on the negative pressure suction nozzle and is adsorbed on the surface of the dura mater.

3. The supplemental device of claim 1, wherein the injection unit comprises:

the injection cavity is embedded in the negative pressure unit, and the outer wall of the injection cavity is integrally connected with the outer wall of the negative pressure unit;

and the injection piston is connected with the second end of the injection cavity and is connected with the second end of the column core.

4. The auxiliary device according to claim 2, wherein the negative pressure suction cup is a ring-shaped structure; the inner ring of the negative pressure sucker is sleeved at the first end of the injection unit, and the outer ring of the negative pressure sucker is sleeved with the negative pressure suction nozzle;

the end part of the first end of the negative pressure cavity is provided with at least one negative pressure suction hole, and the negative pressure suction holes are uniformly distributed along the circumferential direction of the first end of the negative pressure cavity.

5. The auxiliary device of claim 2, wherein the negative pressure cavity is an L-shaped structure, the negative pressure cavity comprising a first sub-cavity and a second sub-cavity; the injection unit is embedded in the first sub-cavity; the negative pressure piston is connected with the second sub-cavity.

6. A supplementary device according to claim 5, wherein the injection unit is disposed coaxially with the first sub-chamber.

7. A supplementary device according to claim 5, wherein the angle between the axis of the first sub-chamber and the axis of the second sub-chamber is α, wherein 0 ° < α < 180 °.

8. Auxiliary device according to any one of claims 1 to 7, wherein at least one of said flexible electronic devices to be implanted is uniformly distributed along the circumference of said cylindrical core and/or along the radial direction of said cylindrical core.

9. The assistive device of any one of claims 1 to 7, wherein the flexible electronic device to be implanted is in a rolled shape before implantation; the flexible electronic device to be implanted is implanted between the dura mater and the cerebral cortex, and is released to be in a flat state.

10. The assist device according to any one of claims 1 to 7, wherein a sectional shape of the column core is any one of a circle, a rectangle, a polygon, and an ellipse.

Technical Field

The present disclosure relates to the field of flexible electronics, and more particularly, to an auxiliary device for subdural implantation of a flexible electronic device.

Background

Brain science has received wide attention from researchers as a hotspot and difficult point of research in the biomedical field. According to the statistics of the world health organization, the brain-related diseases including various neurological and mental diseases are the most social burden of all the diseases, and account for about 28%. Therefore, diagnosis and intervention of major brain diseases are an extremely important research content in the field of brain science in the future. From 1950s, the brain science realizes the electric signal recording, the research of synapse transmission, the exploration of neural circuits and the application of brain-computer interfaces to 2000s of the development of the systematic neuroscience research, the research progress of the brain science is deeply restricted by research tools, and the development of the research tools have great promoting effect on the research of the brain science. Currently, the measurement tools of brain science include: electroencephalograms (EEG), electrocorticograms (ECoG), calcium imaging techniques, micro-electrode arrays (MEA), Functional Magnetic Resonance Imaging (FMRI), and recording electrode arrangements for single cell action potentials (LFP Spikes). Among the above measuring tools, the electroencephalogram signal measuring tool plays an important role in the aspects of brain function exploration, treatment of neurological diseases, development of human-computer integrated devices, and the like.

EEG, ECoG and LFP Spikes are used as three modes for recording electroencephalogram signals, and the three modes have the advantages and the disadvantages, wherein the measurement of ECoG has less noise interference than EEG, has high bandwidth and power, can be used for recording electroencephalogram signals, and can also be used for electrical stimulation and biochemical stimulation, but certain trauma exists because the device needs to be opened in the skull and implanted under the dura mater, and undoubtedly, the requirements on the implantation mode and the implantation device are provided. In neuroscience, multi-parameter (including various physical signals and chemical quantities) measuring devices are mostly required to be attached to the cerebral cortex and even deeply enter into the brain tissue. The dura mater is an important barrier for protecting the brain under the skull and is an important obstacle in the operation of implanting devices under the dura mater. At present, brain implantation surgery mostly depends on a brain stereotaxic apparatus, an anesthetized animal is placed on a surgery fixing device platform, a dura mater is exposed after craniotomy, the dura mater is holed to the size of the cross section of a flexible electronic device to be implanted under a surgery microscope, a specific device is implanted into a designated area through the brain stereotaxic apparatus, and the device is fixed on the exposed skull through dental cement and screws after release. The implantation mode has great limitation on implantation devices, if the electric signals or chemical quantities of large-range and multi-brain areas need to be measured, large-area and multi-channel devices are needed, large-aperture and most quantity of dura mater open windows are required, and the larger the area of the dura mater open windows is, certain influence is caused on parameters such as intracranial pressure, the risk of damage to brain tissues of animals is increased, and even the life of experimental animals is endangered. The above problems greatly limit the application of functional devices for large-scale, multi-brain-area, multi-parameter measurement, brain-area stimulation and drug delivery.

Therefore, there is a need to develop a new device to enable subdural flexible electronics implantation through a small opening window of the skull.

Disclosure of Invention

Technical problem to be solved

The present disclosure provides an auxiliary device for subdural implantation of a flexible electronic device to solve the above-mentioned technical problems.

(II) technical scheme

According to one aspect of the present disclosure, there is provided an auxiliary device for subdural implantation of a flexible electronic device, comprising:

at least one flexible electronic device to be implanted connected to the first end of the core;

a negative pressure unit adsorbed on the surface of the dura mater;

the injection unit is connected with the second end of the column core, is embedded in the negative pressure unit and is integrally connected with the negative pressure unit;

the negative pressure unit generates negative pressure, the negative pressure unit attracts and grabs the surface of the dura mater, and a space is generated between the surface of the dura mater and the cerebral cortex; the injection unit pushes the column core to enable the flexible electronic device to be implanted between the dura mater and the cerebral cortex.

In some embodiments of the present disclosure, the negative pressure unit includes:

the negative pressure suction nozzle is sleeved at the end part of the first end of the negative pressure cavity;

the negative pressure piston is connected with the second end of the negative pressure cavity;

and the negative pressure suction cup is sleeved on the negative pressure suction nozzle and is adsorbed on the surface of the dura mater.

In some embodiments of the present disclosure, the injection unit comprises:

the injection cavity is embedded in the negative pressure unit, and the outer wall of the injection cavity is integrally connected with the outer wall of the negative pressure unit;

and the injection piston is connected with the second end of the injection cavity and is connected with the second end of the column core.

In some embodiments of the present disclosure, the negative pressure suction cup is a ring structure; the inner ring of the negative pressure sucker is sleeved at the first end of the injection unit, and the outer ring of the negative pressure sucker is sleeved with the negative pressure suction nozzle;

the end part of the first end of the negative pressure cavity is provided with at least one negative pressure suction hole, and the negative pressure suction holes are uniformly distributed along the circumferential direction of the first end of the negative pressure cavity.

In some embodiments of the present disclosure, the negative pressure chamber is an L-shaped structure, the negative pressure chamber comprising a first sub-chamber and a second sub-chamber; the injection unit is embedded in the first sub-cavity; the negative pressure piston is connected with the second sub-cavity.

In some embodiments of the present disclosure, the injection unit is disposed coaxially with the first subcavity.

In some embodiments of the present disclosure, the included angle between the axis of the first sub-cavity and the axis of the second sub-cavity is α, wherein 0 ° < α < 180 °.

In some embodiments of the present disclosure, at least one of the flexible electronic devices to be implanted is uniformly distributed along a circumferential direction of the pillar core and/or along a radial direction of the pillar core.

In some embodiments of the present disclosure, the flexible electronic device to be implanted is in a rolled shape before implantation; the flexible electronic device to be implanted is implanted between the dura mater and the cerebral cortex, and is released to be in a flat state.

In some embodiments of the present disclosure, the cross-sectional shape of the pillar core is any one of circular, rectangular, polygonal, and elliptical.

(III) advantageous effects

According to the technical scheme, the auxiliary device implanted under the dura mater of the flexible electronic device has at least one or part of the following beneficial effects:

(1) the arrangement of the negative pressure unit can grasp and lift the dura mater by utilizing the negative pressure suction, so that the distance between the dura mater and the cerebral cortex is increased, the implantation space of a device under the dura mater is greatly increased, and the device can be implanted conveniently.

(2) According to the method, the column core is adopted to carry the flexible electronic device to be implanted, the device which is multidirectional and wide in coverage area can be synchronously implanted through a single small-diameter opening window, the large-diameter and large-quantity dura mater opening window is avoided, the implantation operation process is simplified, and the damage risk to the brain tissue of the animal is reduced.

(3) According to the vacuum unit, the negative pressure cavity and the injection cavity are spliced and assembled, and the sealing performance of the suction passage in the negative pressure unit is ensured.

Drawings

Fig. 1 is a schematic view of an auxiliary device implanted under dura mater of a flexible electronic device according to an embodiment of the present disclosure.

FIG. 2 is a schematic view of a procedure for implanting a device using an auxiliary device implanted subdural of a flexible electronic device according to an embodiment of the disclosure.

[ description of main reference numerals in the drawings ] of the embodiments of the present disclosure

1: an injection unit;

1-1: an injection cavity;

1-2: an injection piston;

2: a negative pressure unit;

2-1: a negative pressure cavity;

2-2: a negative pressure piston;

3: a column core;

4: a flexible electronic device to be implanted;

5: a negative pressure suction hole;

6: a negative pressure suction nozzle;

7: a negative pressure sucker;

8: the dura mater;

9: the cerebral cortex.

Detailed Description

The present disclosure provides an auxiliary device for subdural implantation of a flexible electronic device, comprising: the device comprises a column core, a negative pressure unit and an injection unit. At least one flexible electronic device to be implanted is connected to the first end of the stem and an injection unit is connected to the second end of the stem. The injection unit is embedded in the negative pressure unit and is integrally connected with the negative pressure unit. The dura mater is grabbed and lifted by utilizing the negative pressure attraction, the distance between the dura mater and the cerebral cortex is increased, the stretching and expanding space of the device dura mater after implantation is greatly increased, and the device is more convenient to implant.

For the purpose of promoting a better understanding of the objects, aspects and advantages of the present disclosure, reference is made to the following detailed description taken in conjunction with the accompanying drawings.

Certain embodiments of the present disclosure will now be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the disclosure are shown. Indeed, various embodiments of the disclosure may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will satisfy applicable legal requirements.

In a first exemplary embodiment of the present disclosure, an assistive device for subdural implantation of a flexible electronic device is provided. Fig. 1 is a schematic view of an auxiliary device implanted under dura mater of a flexible electronic device according to an embodiment of the present disclosure. As shown in fig. 1, the auxiliary device for subdural implantation of a flexible electronic device of the present disclosure includes: an injection unit 1, a negative pressure unit 2 and a column core 3. At least one flexible electronic device 4 to be implanted is connected to a first end of the core 3 and the injection unit 1 is connected to a second end of the core 3. The injection unit 1 is embedded in the negative pressure unit 2, and the injection unit 1 and the negative pressure unit 2 are integrally connected.

The following describes each component of the auxiliary device for subdural implantation of the flexible electronic device of this embodiment in detail.

The negative pressure unit 2 in one embodiment of the present disclosure includes: a negative pressure cavity 2-1, a negative pressure piston 2-2 and a negative pressure sucker 7. The negative pressure suction nozzle 6 is sleeved at the end part of the first end of the negative pressure cavity 2-1, and the negative pressure piston 2-2 is connected with the second end of the negative pressure cavity 2-1. The negative pressure sucker 7 is sleeved on the negative pressure suction nozzle 6, and the negative pressure sucker 7 is adsorbed on the surface of the dura mater 8.

Regarding the structure of the negative pressure pad 7, the negative pressure pad 7 has a ring-shaped structure. Specifically, the inner ring of the negative pressure sucker 7 is sleeved at the first end of the injection unit 1, and the outer ring of the negative pressure sucker 7 is sleeved with the negative pressure suction nozzle 6. The material of the negative pressure sucker 7 is silica gel, PDMS or Ecoflex.

The end part of the first end of the negative pressure cavity 2-1 is provided with at least one negative pressure suction hole 5, and the negative pressure suction holes 5 are uniformly distributed along the circumferential direction of the first end of the negative pressure cavity 2-1. The negative pressure suction holes 5 can penetrate through the negative pressure cavity and the tissue to be implanted, so that the smoothness of an air passage in the process of sucking the tissue surface membrane is ensured.

In one embodiment of the negative pressure chamber 2-1, the negative pressure chamber 2-1 is an L-shaped structure, which facilitates the injection operation of the injection unit 1. Specifically, the negative pressure chamber 2-1 includes a first sub-chamber and a second sub-chamber. The injection unit 1 is embedded in the first sub-cavity; and the negative pressure piston 2-2 is connected with the second sub-cavity.

Optionally, the injection unit 1 is arranged coaxially with the first sub-chamber, or the injection unit 1 is arranged non-coaxially with the first sub-chamber.

The following embodiments are possible with respect to the distribution of the first and second sub-cavities.

Example 1

The first sub-cavity and the second sub-cavity are vertically arranged. That is, the included angle between the axis of the first sub-cavity and the axis of the second sub-cavity is α, where α is 90 °.

Example 2

The first sub-cavity and the second sub-cavity are not vertically arranged. I.e. the angle between the axis of the first sub-chamber and the axis of the second sub-chamber is alpha, wherein alpha is more than 0 degrees and less than 90 degrees, or alpha is more than 90 degrees and less than 180 degrees.

The negative pressure unit 2 in another embodiment of the present disclosure may be any device capable of generating negative pressure, such as an injector and an air pump, so as to generate negative pressure in the cavity, and is not limited to the negative pressure unit 2 disclosed in the foregoing embodiments.

The negative pressure unit 2 is arranged, and the negative pressure suction has great advantages for the film or cavity tissue with a gap between the negative pressure unit and the solid tissue, so that the operable space is increased, and meanwhile, the damage to the tissue is greatly reduced.

An injection unit 1 in one embodiment of the present disclosure comprises: an injection cavity 1-1 and an injection piston 1-2.

The injection cavity 1-1 is embedded in the negative pressure unit 2, and the outer wall of the injection cavity 1-1 is integrally connected with the outer wall of the negative pressure unit 2.

For example, the injection cavity 1-1 and the negative pressure cavity 2-1 integrally connect the outer wall of the injection cavity 1-1 and the outer wall of the negative pressure unit 2 through light curing glue.

In some embodiments, the injection chamber 1-1 and the negative pressure chamber 2-1 may be an integral structure that is embedded inside and outside.

For example, a polymer (e.g., PMMA, PP, etc.) is poured into the cavity mold to form an injection cavity 1-1 and a negative pressure cavity 2-1 which can be embedded in and out.

The injection piston 1-2 is connected to the second end of the injection chamber 1-1 and the injection piston 1-2 is connected to the second end of the plunger 3.

The following description is made in detail with respect to the distribution of the flexible electronic device 4 to be implanted on the core 3.

At least one flexible electronic device 4 to be implanted is uniformly distributed along the circumference of the cylindrical core 3 (i.e. horizontally distributed in the figure), or at least one flexible electronic device 4 to be implanted is uniformly distributed along the radial direction of the cylindrical core 3 (i.e. vertically distributed in the figure), or a plurality of flexible electronic devices 4 to be implanted are uniformly distributed along the circumference and the radial direction of the cylindrical core 3 at the same time.

Further, as for the cross-sectional shape of the pillar core 3, any one of a circle, a rectangle, a polygon and an ellipse may be used, and other geometric shapes not listed may also be applicable, and are not limited herein.

In some embodiments, the flexible electronic device 4 to be implanted is crimped prior to implantation. The flexible electronic device 4 to be implanted is implanted between the dura mater 8 and the cerebral cortex 9, the flexible electronic device 4 to be implanted in a curled shape is released by hydrolyzing the water-soluble polymer or opening the fixing device to drive, so that the flexible electronic device 4 to be implanted in a curled shape is completely unfolded until the flexible electronic device 4 to be implanted is in a flat shape.

According to the flexible electronic device 4, a plurality of flexible electronic devices 4 to be implanted can be injected and implanted into the cerebral cortex 9 area or the brain tissue below the dura mater 8 through the injection unit 1 through a single small opening window, each flexible electronic device 4 to be implanted is suitable for measuring physical quantities such as electroencephalogram signals, brain pressure and temperature and chemical quantities such as neurotransmitters, various ions and glucose in a large range and multiple brain areas, and is used for stimulating and administering drugs in a specific brain area without opening the dura mater 8 window with a large aperture and a large quantity, so that the damage of the animal brain tissue caused by the increase of the number and the area of the dura mater 8 opening windows is greatly reduced.

FIG. 2 is a schematic view of a procedure for implanting a device using an auxiliary device implanted subdural of a flexible electronic device according to an embodiment of the disclosure. As shown in figure 2 of the drawings, in which,

in A, the negative pressure suction cup 7 of the negative pressure unit 2 is adsorbed on the surface of the dura mater 8.

In step B, the negative pressure piston 2-2 is pulled outwards (leftwards in the figure), at the moment, negative pressure is generated in the negative pressure cavity 2-1, the negative pressure suction device 7 sucks and grabs the surface of the dura mater 8, and a space is generated between the surface of the dura mater 8 and the cerebral cortex 9, so that the expansion space of the flexible electronic device with expandable morphological change after being implanted is increased.

In step C, the injection piston 1-2 of the injection unit 1 pushes the plunger 3 downward (as viewed in the figure) to implant the flexible electronic device 4 between the surface of the dura mater 8 and the cerebral cortex 9.

And D, after the flexible electronic device 4 to be implanted is implanted between the dura mater 8 and the cerebral cortex 9, the flexible electronic device 4 to be implanted in a curled shape is released by hydrolyzing the water-soluble polymer or opening the fixing device to drive, so that the flexible electronic device 4 to be implanted in a curled shape is completely unfolded until the flexible electronic device 4 to be implanted is in a flat shape.

The auxiliary device for subdural implantation of the flexible electronic device is suitable for, but not limited to, implantation of any shape-expandable change device which enters the subdural space through a small opening window of a skull.

So far, the embodiments of the present disclosure have been described in detail with reference to the accompanying drawings. It is to be noted that, in the attached drawings or in the description, the implementation modes not shown or described are all the modes known by the ordinary skilled person in the field of technology, and are not described in detail. Further, the above definitions of the various elements and methods are not limited to the various specific structures, shapes or arrangements of parts mentioned in the examples, which may be easily modified or substituted by those of ordinary skill in the art.

From the above description, those skilled in the art should clearly recognize that the auxiliary device for subdural implantation of the flexible electronic device of the present disclosure has been disclosed.

In conclusion, the auxiliary device for implanting the device under the dura mater of the flexible electronic device, which is provided by the disclosure, can grasp and lift the dura mater by utilizing negative pressure suction and increase the distance between the dura mater and the cerebral cortex, greatly increases the implantation space of the device under the dura mater, is more convenient for implanting the device, and has important significance for promoting the research progress of neuroscience.

It should also be noted that directional terms, such as "upper", "lower", "front", "rear", "left", "right", and the like, used in the embodiments are only directions referring to the drawings, and are not intended to limit the scope of the present disclosure. Throughout the drawings, like elements are represented by like or similar reference numerals. Conventional structures or constructions will be omitted when they may obscure the understanding of the present disclosure.

And the shapes and sizes of the respective components in the drawings do not reflect actual sizes and proportions, but merely illustrate the contents of the embodiments of the present disclosure. Furthermore, in the claims, any reference signs placed between parentheses shall not be construed as limiting the claim.

Furthermore, the word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements.

The use of ordinal numbers such as "first," "second," "third," etc., in the specification and claims to modify a corresponding element does not by itself connote any ordinal number of the element or any ordering of one element from another or the order of manufacture, and the use of the ordinal numbers is only used to distinguish one element having a certain name from another element having a same name.

Similarly, it should be appreciated that in the foregoing description of exemplary embodiments of the disclosure, various features of the disclosure are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure and aiding in the understanding of one or more of the various disclosed aspects. However, the disclosed method should not be interpreted as reflecting an intention that: that is, the claimed disclosure requires more features than are expressly recited in each claim. Rather, as the following claims reflect, disclosed aspects lie in less than all features of a single foregoing disclosed embodiment. Thus, the claims following the detailed description are hereby expressly incorporated into this detailed description, with each claim standing on its own as a separate embodiment of this disclosure.

The above-mentioned embodiments are intended to illustrate the objects, aspects and advantages of the present disclosure in further detail, and it should be understood that the above-mentioned embodiments are only illustrative of the present disclosure and are not intended to limit the present disclosure, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present disclosure should be included in the scope of the present disclosure.