阅读说明：本技术 一种低功耗的植入式闭环自响应神经刺激系统 (Low-power-consumption implantable closed-loop self-response nerve stimulation system ) 是由 周华明 陈新蕾 曹鹏 于 2021-02-05 设计创作，主要内容包括：本发明涉及一种低功耗的植入式闭环自响应神经刺激系统,包括体外装置和植入体装置,所述体外装置通过无线通讯连接至植入体装置,所述植入体装置包括电源电路、采样电路、刺激电路、通讯模块、存储模块和MCU,所述体外装置包括无线通讯模块、通讯唤醒模块和磁铁；所述采样电路、刺激电路、通讯模块、存储模块均电性连接至MCU,所述无线通讯模块电性连接至充电模块,所述磁铁通讯连接至MCU。本发明能够运行在不同模式,在通讯过程中通过单片机提高功率满足响应模式需求,通过降低通讯时间占比维持较低功耗,满足通讯过程中的正常运行。(The invention relates to an implanted closed-loop self-response nerve stimulation system with low power consumption, which comprises an in-vitro device and an implanted device, wherein the in-vitro device is connected to the implanted device through wireless communication; the sampling circuit, the stimulation circuit, the communication module and the storage module are all electrically connected to the MCU, the wireless communication module is electrically connected to the charging module, and the magnet is in communication connection with the MCU. The invention can operate in different modes, the power is improved by the singlechip to meet the requirement of a response mode in the communication process, and the normal operation in the communication process is met by reducing the communication time ratio and maintaining lower power consumption.)

1. An implantable closed-loop self-response nerve stimulation system with low power consumption is characterized by comprising an in vitro device and an implant device, wherein the in vitro device is connected to the implant device through wireless communication; the sampling circuit, the stimulation circuit, the communication module and the storage module are all electrically connected to the MCU, the wireless communication module is electrically connected to the charging module, and the magnet is in communication connection with the MCU.

2. The low-power-consumption implantable closed-loop self-responding neurostimulation system according to claim 1, wherein the communication awakening module comprises a control module, a voltage output module and a charging coil, the control module is communicatively connected to the communication module through a wireless communication module, and the control module is further communicatively connected to the communication module through the voltage output module and the charging coil.

3. The low-power implantable closed-loop self-responding neurostimulation system according to claim 1, wherein the extracorporeal device and the implantable device adopt bluetooth communication, and bluetooth chips are disposed in the communication module and the wireless communication module.

4. The low power implantable closed loop self-responding neurostimulation system according to claim 1, wherein the memory module employs FRAM.

5. The low power consumption implantable closed-loop self-responsive neurostimulation system according to claim 2, wherein the operating modes of the low power consumption implantable closed-loop self-responsive neurostimulation system comprise a low power consumption mode and a communication mode.

6. The low-power-consumption implantable closed-loop self-response neurostimulation system according to claim 5, wherein in the low-power-consumption mode, the MCU collects the electroencephalogram signals through the control stimulation circuit and the sampling circuit at a preset sampling frequency, and stores the electroencephalogram signals to the storage module according to a preset trigger condition.

7. The low-power implantable closed-loop self-responding neurostimulation system according to claim 5, wherein in the communication mode, the control module wakes up the communication module through the charging coil, so that the communication between the communication module and the wireless communication module is established; and the control module sends an instruction to the MCU, and the MCU responds and sends the brain power information to the control module.

8. The low-power-consumption implantable closed-loop self-response neurostimulation system is characterized in that in the low-power-consumption mode, the MCU can be manually triggered through a triggering medium of an external instruction from a magnet, and the electroencephalogram signal is collected by using the stimulation circuit and the sampling circuit.

9. The low-power-consumption implantable closed-loop self-response neurostimulation system is characterized in that the sending interval of the brain electrical information sent by the MCU to the control module is the maximum value among the sampling time of the MCU, the refreshing time of the control module and the communication delay between the MCU and the control module.

Technical Field

The invention belongs to the field of signal transmission, and particularly relates to an implanted closed-loop self-response nerve stimulation system with low power consumption.

Background

Implantable medical devices belong to miniature medical devices, are various, such as implantable cardiac pacemakers, defibrillators, implantable nerve stimulators, implantable muscle stimulators, implantable physiological signal recorders, implantable drug pumps and the like, generally comprise an in-vivo implanted device and an in-vitro control device, and exchange information between the in-vivo implanted device and the in-vitro control device through bidirectional wireless communication.

The power consumption of the intracorporeal implanted device determines the service life of the product, the lower the power consumption, the longer the service life of the product, the longer the product life, the less frequent the surgical replacement for the patient, the lower the medical cost and the less pain of the operation. The communication circuit for the wireless communication between the in-vivo implanted device and the in-vitro control device consumes battery energy and also requires low power consumption, while the power consumption of the common radio frequency wireless communication circuit during working is larger than that of the implanted medical equipment, and a certain method is needed to reduce the average power consumption of the wireless communication circuit.

In the prior art, two working states, namely an interception working state and an awakening working state, are generally adopted, the implantable medical device is in the interception working state after being powered on, each cycle period T of the interception working state comprises an awakening period T1 and a sleeping period T-T1, a wireless communication circuit is turned on during the awakening period, power consumption is high, the wireless communication circuit is turned off during the sleeping period, and power consumption is low, so that average power consumption of the wireless communication circuit is reduced. However, the average power consumption of the listening operation state depends on the duty ratio of the wake-up time T1 and the cycle period T, and no matter how, a certain power consumption exists, and to obtain a good communication real-time response effect, the duty ratio of the wake-up time T1 and the cycle period T cannot be too small, and the final average power consumption still occupies a certain proportion in the overall power consumption. In fact, the time for the in vivo implanted device to need external program control is very short, and program control is not needed for most of the time, so that most of average power consumption for monitoring the working state in the prior art is wasted.

Disclosure of Invention

In order to solve the problems, the invention provides an implanted closed-loop self-response nerve stimulation system with low power consumption, which can operate in different modes, the power is improved by a singlechip in the communication process to meet the requirement of the response mode, and the normal operation in the communication process is met by reducing the communication time ratio and maintaining the low power consumption.

The technical scheme of the invention is as follows:

an implantable closed-loop self-response nerve stimulation system with low power consumption comprises an in-vitro device and an implant device, wherein the in-vitro device is connected to the implant device through wireless communication, the implant device comprises a power circuit, a sampling circuit, a stimulation circuit, a communication module, a storage module and an MCU (microprogrammed control unit), and the in-vitro device comprises a wireless communication module, a communication awakening module and a magnet; the sampling circuit, the stimulation circuit, the communication module and the storage module are all electrically connected to the MCU, the wireless communication module is electrically connected to the charging module, and the magnet is in communication connection with the MCU.

Preferably, the communication awakening module comprises a control module, a voltage output module and a charging coil, the control module is in communication connection with the communication module through the wireless communication module, and the control module is also in communication connection with the communication module through the voltage output module and the charging coil.

Preferably, the in-vitro device and the implant device adopt Bluetooth communication, and Bluetooth chips are arranged in the communication module and the wireless communication module.

Preferably, the storage module adopts FRAM.

Preferably, the operation modes of the low-power-consumption implantable closed-loop self-response nerve stimulation system comprise a low-power-consumption mode and a communication mode.

Preferably, in the low power consumption mode, the MCU collects the electroencephalogram signals at a preset sampling frequency by controlling the stimulation circuit and the sampling circuit, and stores the electroencephalogram signals according to a preset trigger condition to be cached in the storage module.

Preferably, in the communication mode, the control module wakes up the communication module through the charging coil, so that communication is established between the communication module and the wireless communication module; and the control module sends an instruction to the MCU, and the MCU responds and sends the brain power information to the control module.

Preferably, in the low power consumption mode, the MCU can be manually triggered through a triggering medium of an external instruction from the magnet, and the electroencephalogram signals are collected by using the stimulation circuit and the sampling circuit.

Preferably, the sending interval at which the MCU sends the brain electrical information to the control module is the maximum of the sampling time of the MCU, the refresh time of the control module, and the communication delay between the MCU and the control module.

The technical effects of the invention are as follows:

the system provided by the invention continuously detects the electroencephalogram through the implant part and operates in a low-power mode; when the detected electroencephalogram signal triggers a stimulation threshold, entering a response mode; when the implant is communicated with the outside for data transmission or charging, the communication mode is switched. The communication mode meets the requirement of the response mode by improving the power of the singlechip, and meets the normal operation in the communication process by reducing the communication time ratio and maintaining lower power consumption.

Drawings

FIG. 1 is a connection block diagram of the present invention.

Detailed Description

The embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

As shown in fig. 1, an implantable closed-loop self-response neurostimulation system with low power consumption comprises an external device and an implant device, wherein the implant comprises an MCU, a power module for supplying power to the implant device, a sampling circuit and a stimulation circuit which are in contact with tissues through electrodes, and a communication module which is in communication with the external part of the body, and the external device comprises a wireless communication module, a communication wakeup module and a magnet; the sampling circuit, the stimulation circuit, the communication module and the storage module are all electrically connected to the MCU, the wireless communication module is electrically connected to the charging module, and the magnet is in communication connection with the MCU.

As an embodiment of the present invention, the communication wake-up module includes a control module, a voltage output module and a charging coil, the control module is communicatively connected to the communication module through the wireless communication module, the control module is further communicatively connected to the communication module through the voltage output module and the charging coil, and the control module and the communication module may belong to the same device or may exist independently.

As an embodiment of the present invention, the extracorporeal device and the implant device use bluetooth communication, and bluetooth chips are disposed in the communication module and the wireless communication module.

As an implementation mode of the invention, the storage module adopts FRAM to cache the electroencephalogram information.

As one embodiment of the invention, the operation modes of the low-power-consumption implantable closed-loop self-response nerve stimulation system comprise a low-power-consumption mode and a communication mode.

As an embodiment of the invention, in a low power consumption mode, the MCU collects electroencephalogram signals through the control stimulation circuit and the sampling circuit at a preset sampling frequency, and stores the electroencephalogram signals according to a preset trigger condition and caches the electroencephalogram signals to the storage module, wherein the sampling frequency is set between 100 Hz and 2000Hz in this embodiment; under the low-power consumption mode, the MCU can be manually triggered through a triggering medium of an external instruction from the magnet, the electroencephalogram signals are collected by utilizing the stimulation circuit and the sampling circuit, when the independent magnet passes through the implant, the MCU module executes a specific instruction, and the instruction is used for searching real-time electroencephalogram information recorded and stored in the embodiment.

As an embodiment of the present invention, in the communication mode, the control module wakes up the communication module through the charging coil, so that communication is established between the communication module and the wireless communication module; control module sends the instruction to MCU, and MCU makes the response and sends brain electricity information to control module, and control module draws the implant behind the charging coil output voltage with specific frequency in this affair example, awakens up communication module, and the communication module and the implant communication of external part of body simultaneously, specific awakening frequency sets up to 2.4G in this embodiment.

As an embodiment of the present invention, a transmission interval at which the MCU transmits the brain electrical information to the control module takes a maximum value among sampling time of the MCU, refresh time of the control module, and communication delay between the MCU and the control module.

The method is divided into a communication mode and a low-power-consumption mode, and the acquisition of the electroencephalogram signals is finished in a dual-mode cross operation mode, wherein when the electroencephalogram signals trigger a threshold value in the MCU, the electroencephalogram signals can also enter a transient response mode, and the response mode is used as an excessive state for preparing to enter communication; the power consumption is higher under the communication mode, and after the information transmission is accomplished, gather the EEG signal again, judge the mode that needs to get into next step, all be in low-power consumption mode under the ordinary condition, and can pass through magnet manual trigger MCU record EEG signal, get into the communication mode, conveniently record information.

Finally, it should be noted that: the above-mentioned embodiments are only specific embodiments of the present invention, which are used for illustrating the technical solutions of the present invention and not for limiting the same, and the protection scope of the present invention is not limited thereto, although the present invention is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: any person skilled in the art can modify or easily conceive the technical solutions described in the foregoing embodiments or equivalent substitutes for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the present invention in its spirit and scope. Are intended to be covered by the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.