阅读说明：本技术 植入式低功耗闭环自响应系统的实时监控装置、方法 (Real-time monitoring device and method of implanted low-power-consumption closed-loop self-response system ) 是由 陈新蕾 周华明 曹鹏 于 2021-02-05 设计创作，主要内容包括：本发明涉及一种植入式低功耗闭环自响应系统的实时监控装置,包括上位机和下位机,所述下位机包括植入式的信号采集模块、刺激模块、无线通讯模块、MCU和RAM,所述信号采集模块经RAM、MCU电性连接至刺激模块,所述无线通讯模块分别与刺激模块、MCU电性连接。本发明能够在上位机设置采集参数,下位机根据给定参数调整信号发送方式,通过维持通讯过程的低功耗实现；且可以将闭环系统的工作过程在上位机上重现,可以观察刺激对患者脑电的影响。(The invention relates to a real-time monitoring device of an implanted low-power-consumption closed-loop self-response system, which comprises an upper computer and a lower computer, wherein the lower computer comprises an implanted signal acquisition module, a stimulation module, a wireless communication module, an MCU (microprogrammed control unit) and an RAM (random access memory), the signal acquisition module is electrically connected to the stimulation module through the RAM and the MCU, and the wireless communication module is respectively electrically connected with the stimulation module and the MCU. The invention can set acquisition parameters at the upper computer, and the lower computer adjusts the signal sending mode according to the given parameters and is realized by maintaining the low power consumption of the communication process; and the working process of the closed-loop system can be reproduced on the upper computer, and the influence of stimulation on the electroencephalogram of the patient can be observed.)

1. The utility model provides a real-time monitoring device of implanted low-power consumption closed loop self-response system which characterized in that, includes host computer and next machine, the next machine includes implanted signal acquisition module, stimulation module, wireless communication module, MCU and RAM, signal acquisition module is through RAM, MCU electric connection to stimulation module, wireless communication module respectively with stimulation module, MCU electric connection.

2. The real-time monitoring device of the implanted low-power closed-loop self-response system according to claim 1, wherein the upper computer is a mobile terminal device with a bluetooth function.

3. The device for real-time monitoring of an implantable low-power closed-loop self-response system according to claim 1, wherein the signal acquisition module employs a bioelectricity acquisition circuit, the wireless communication module employs a bluetooth communication module, and the stimulation module is a constant current stimulation circuit.

4. A real-time monitoring method of an implanted low-power-consumption closed-loop self-response system is characterized by comprising a closed-loop stimulation mode and a real-time monitoring mode of a lower computer;

the specific working mode of the real-time monitoring mode is as follows:

1) the upper computer sends a control signal to the stimulation module through the wireless communication technology and the wireless communication module, and the control signal is used for adjusting the stimulation module;

2) the MCU transmits the electroencephalogram data to the upper computer through the wireless communication module according to a signal acquisition instruction sent by the upper computer, so that the real-time monitoring of the sampling process is realized;

the closed loop test mode comprises the following specific working steps: MCU sends the collection order to signal acquisition module by oneself according to the preconfiguration information that the host computer was issued, gather the EEG signal of human body by signal acquisition module, MCU stores the information of gathering to RAM with the form of sampling point in, MCU adjusts stimulation module through embedded algorithm and the EEG signal of gathering, MCU passes through communication module and conveys the upper computer to the sampling point in gathering RAM.

5. The method of claim 4, wherein in the real-time monitoring mode, the wireless communication module is in a sleep state when the stimulation module is operating, and the stimulation module wakes up the wireless communication module and starts to transmit data when stopping.

6. The real-time monitoring method of the implanted low-power closed-loop self-response system according to claim 4, wherein the wake-up frequency is 2.4G, and the wake-up time of wireless communication in the process of electroencephalogram signal acquisition is less than 8 seconds.

7. The method for real-time monitoring of the implantable low-power closed-loop self-response system according to claim 4, wherein the signal acquisition command comprises a sampling channel and a sampling rate, and the sampling rate is set between 100 Hz and 2000 Hz.

8. A user equipment comprising a memory, a processor and a computer program stored in the memory and executable on the processor, characterized in that the processor implements the steps of the method according to any of claims 4 to 7 when executing the computer program.

9. A computer-readable storage medium, in which a computer program is stored which, when being executed by a processor, carries out the steps of the method according to any one of claims 4 to 7.

Technical Field

The invention belongs to the field of signal transmission, and particularly relates to a real-time monitoring device and method of an implanted low-power-consumption closed-loop self-response system.

Background

Implantable medical devices belong to miniature medical devices, are various, such as implantable cardiac pacemakers, defibrillators, implantable nerve stimulators, implantable muscle stimulators, implantable physiological signal recorders, implantable drug pumps and the like, generally comprise an in-vivo implanted device and an in-vitro control device, and exchange information between the in-vivo implanted device and the in-vitro control device through bidirectional wireless communication.

The power consumption of the intracorporeal implanted device determines the service life of the product, the lower the power consumption, the longer the service life of the product, the longer the product life, the less frequent the surgical replacement for the patient, the lower the medical cost and the less pain of the operation. The communication circuit for the wireless communication between the in-vivo implanted device and the in-vitro control device consumes battery energy and also requires low power consumption, while the power consumption of the common radio frequency wireless communication circuit during working is larger than that of the implanted medical equipment, and a certain method is needed to reduce the average power consumption of the wireless communication circuit.

In the prior art, two working states, namely an interception working state and an awakening working state, are generally adopted, the implantable medical device is in the interception working state after being powered on, each cycle period T of the interception working state comprises an awakening period T1 and a sleeping period T-T1, a wireless communication circuit is turned on during the awakening period, power consumption is high, the wireless communication circuit is turned off during the sleeping period, and power consumption is low, so that average power consumption of the wireless communication circuit is reduced. However, the average power consumption of the listening operation state depends on the duty ratio of the wake-up time T1 and the cycle period T, and no matter how, a certain power consumption exists, and to obtain a good communication real-time response effect, the duty ratio of the wake-up time T1 and the cycle period T cannot be too small, and the final average power consumption still occupies a certain proportion in the overall power consumption. In fact, the time for the in vivo implanted device to need external program control is very short, and program control is not needed for most of the time, so that most of average power consumption for monitoring the working state in the prior art is wasted.

Therefore, in the implantable medical system disclosed in patent publication No. CN204034040U, an intracorporeal implantation device of the implantable medical system has at least three operation states, i.e., a sleep operation state, a listening operation state and a wake-up operation state, and the implantable medical system is formed by connecting the intracorporeal implantation device and an extracorporeal control device in a wireless communication manner, and each of the two devices includes: the system comprises a microcontroller module, a wireless communication module and other functional modules; the in vivo implantation device also comprises a magnetic reed switch, and the in vitro control device also comprises an independently placed magnet. The communication module of the in-vivo implanted device is always in a closed state in a dormant working state, and power consumption is not generated; when the doctor needs to program control, the state is manually switched by the external control magnet, so that the internal implantation device enters a monitoring working state to carry out normal communication. The utility model discloses greatly reduced the most extra consumption that does not need programme-controlled time, prolonged the life of product, the usage is extensive, has high economic benefits and social.

Although the power consumption problem can be solved to above-mentioned patent, can not carry out real time monitoring to the sampling process of signal, and can't carry out the normal operating and the transmission of sampling information of implanting the module simultaneously.

Disclosure of Invention

In order to solve the problems, the invention provides a real-time monitoring device and a real-time monitoring method of an implanted low-power closed-loop self-response system, which can set acquisition parameters on an upper computer, adjust a signal sending mode by a lower computer according to given parameters and realize the low power consumption in a communication process by maintaining; and the working process of the closed-loop system can be reproduced on the upper computer, and the influence of stimulation on the electroencephalogram of the patient can be observed.

The technical scheme of the invention is as follows:

the utility model provides an implanted low-power consumption closed loop self-response system's real-time monitoring device, includes host computer and next machine, the next machine includes implanted signal acquisition module, stimulation module, wireless communication module, MCU and RAM, signal acquisition module is through RAM, MCU electric connection to stimulation module, wireless communication module respectively with stimulation module, MCU electric connection.

Preferably, the upper computer adopts mobile terminal equipment with a Bluetooth function.

Preferably, the signal acquisition module adopts a bioelectricity acquisition circuit, the wireless communication module adopts a Bluetooth communication module, and the stimulation module is a constant current stimulation circuit.

The invention provides a real-time monitoring method of an implanted low-power-consumption closed-loop self-response system, which comprises a closed-loop stimulation mode and a real-time monitoring mode of a lower computer;

the specific working mode of the real-time monitoring mode is as follows:

1) the upper computer sends a control signal to the stimulation module through the wireless communication technology and the wireless communication module, and the control signal is used for adjusting the stimulation module;

2) the MCU transmits the electroencephalogram data to the upper computer through the wireless communication module according to a signal acquisition instruction sent by the upper computer, so that the real-time monitoring of the sampling process is realized;

the closed loop test mode comprises the following specific working steps: MCU sends the collection order to signal acquisition module by oneself according to the preconfiguration information that the host computer was issued, gather the EEG signal of human body by signal acquisition module, MCU stores the information of gathering to RAM with the form of sampling point in, MCU adjusts stimulation module through embedded algorithm and the EEG signal of gathering, MCU passes through communication module and conveys the upper computer to the sampling point in gathering RAM.

Preferably, in the real-time monitoring mode, the wireless communication module is in a dormant state when the stimulation module works, and the wireless communication module is awakened and starts to send data when the stimulation module stops.

Preferably, the awakening frequency is 2.4G, and the awakening time of wireless communication in the electroencephalogram signal acquisition process is less than 8 seconds.

Preferably, the signal acquisition instruction comprises a sampling channel and a sampling rate, and the sampling rate is set between 100 Hz and 2000 Hz.

The invention also provides user equipment which comprises a memory, a processor and a computer program stored in the memory and capable of running on the processor, and is characterized in that the processor realizes the steps of the real-time monitoring method of the implanted low-power closed-loop self-response system when executing the computer program.

The invention also provides a computer readable storage medium, which stores a computer program, wherein the computer program is executed by a processor to implement the steps of the real-time monitoring method of the implanted low-power closed-loop self-response system.

The invention has the beneficial effects that:

the electroencephalogram acquisition mode is switched from an embedded processing mode to a wireless transmission mode, the upper computer sets acquisition parameters, the lower computer adjusts a signal sending mode according to given parameters, and the electroencephalogram acquisition mode is realized by maintaining low power consumption in a communication process. The invention can reproduce the working process of the closed-loop system on the upper computer and observe the influence of stimulation on the electroencephalogram of a patient. The lower computer has two working modes of closed-loop stimulation (mode 1) and real-time monitoring (mode 2), and can be switched or started simultaneously.

Drawings

Fig. 1 is a schematic structural diagram of a real-time monitoring system according to the present invention.

Fig. 2 is a flow chart of the closed-loop stimulation mode of the present invention.

Fig. 3 is a flow chart of the real-time monitoring mode of the present invention.

Detailed Description

The embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

As shown in fig. 1, a real-time monitoring device of an implantable low-power-consumption closed-loop self-response system includes an upper computer and a lower computer, wherein the lower computer includes an implantable signal acquisition module, a stimulation module, a wireless communication module, an MCU and an RAM, the signal acquisition module is electrically connected to the stimulation module through the RAM and the MCU, and the wireless communication module is electrically connected to the stimulation module and the MCU respectively.

As an embodiment of the invention, the upper computer adopts mobile terminal equipment with a Bluetooth function.

As an implementation mode of the invention, the signal acquisition module adopts a bioelectricity acquisition circuit, the wireless communication module adopts a Bluetooth communication module, and the stimulation module is a constant-current stimulation circuit.

The invention also provides a real-time monitoring method of the implanted low-power-consumption closed-loop self-response system, and the low-power-consumption real-time monitoring device is utilized.

As an embodiment of the present invention, the lower computer has two working modes, i.e., closed-loop stimulation (mode 1) and real-time monitoring (mode 2), and can be switched to each other or simultaneously turned on.

As an embodiment of the present invention, as shown in fig. 2, the specific steps of mode 1 are as follows: the MCU automatically sends a collection command to the signal collection module according to preconfigured information sent by the upper computer, the signal collection module collects electroencephalogram signals of a human body, the MCU stores the collected information into the RAM in a sampling point form, the MCU adjusts the stimulation module through an embedded algorithm (typical algorithm is specifically algorithm such as line length and area) and the collected electroencephalogram signals, and the MCU transmits the sampling point in the collection RAM to the upper computer through the communication module.

As an embodiment of the present invention, as shown in fig. 3, in mode 2, the upper computer controls the stimulation module of the lower computer through wireless communication, and adjusts the stimulator in real time; the MCU of the lower computer sets a certain communication module awakening frequency according to a signal acquisition instruction set by the upper computer, and sends sampling points stored in the RAM, so that real-time monitoring of the sampling process is realized.

As an embodiment of the present invention, in mode 2, when the lower computer is adjusted by the MCU to start stimulation, the communication switch is woken up and a start flag is sent, and when stimulation is started, the communication is stopped, and after stimulation is ended, the communication switch is woken up and a stop flag is sent, so as to implement low-power consumption real-time monitoring of the closed-loop stimulation process.

As an implementation mode of the invention, the signal acquisition instruction comprises a sampling channel, a sampling rate and the like, the sampling rate is between 100 Hz and 2000Hz, the communication wake-up time in the sampling process is about 0.1% (less than 0.8), and the low power consumption in the sampling process is realized.

The invention also provides user equipment which comprises a memory, a processor and a computer program stored in the memory and capable of running on the processor, wherein the processor executes the computer program to realize the steps of the real-time monitoring method of the implanted low-power closed-loop self-response system.

The invention also provides a computer readable storage medium, which stores a computer program, and the computer program is executed by a processor to realize the steps of the real-time monitoring method of the implanted low-power-consumption closed-loop self-response system.

According to the invention, a hardware system is combined with a software algorithm in an MCU, actual operation conditions are divided into a real-time monitoring mode and a closed-loop stimulation closed-loop mode, an upper computer does not participate in calculation of actual data, updating of instructions and the like and is used as a storage receiving end, a closed-loop state can be formed to realize transmission and storage of data, and reference data under daily conditions are collected; under the real-time monitoring mode, the upper computer participates in system data interaction, signals are acquired in a targeted mode through the preset awakening frequency in the MCU, and real-time data are provided to the upper computer to be combined with reference data subsequently to be subjected to data analysis.

Finally, it should be noted that: the above-mentioned embodiments are only specific embodiments of the present invention, which are used for illustrating the technical solutions of the present invention and not for limiting the same, and the protection scope of the present invention is not limited thereto, although the present invention is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: any person skilled in the art can modify or easily conceive the technical solutions described in the foregoing embodiments or equivalent substitutes for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the present invention in its spirit and scope. Are intended to be covered by the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.