阅读说明：本技术 用于提供保护屏障的组合物 (Composition for providing a protective barrier ) 是由 Z·马龙 P·P·邦瓦莱 苏珊·哈尔佩恩基尔驰 L·约瑟夫森 于 2019-09-24 设计创作，主要内容包括：一种组合物提供保护屏障并且包含：二山嵛酸甘油酯、三山嵛酸甘油酯和山嵛酸甘油酯；表面活性剂,所述表面活性剂包含硬脂酸甘油酯；一种或多种脂肪化合物；以及一种或多种甘油三酯。所述组合物任选地包含水合剂并且可以基本上不含或不含凡士林、矿物油和水中的一种或多种。所述组合物提供与包含凡士林、矿物油和羊毛脂中的一种或多种的组合物相当的封闭性效果和水合效果。(A composition provides a protective barrier and comprises: glyceryl dibehenate, glyceryl tribehenate and glyceryl behenate; a surfactant comprising glyceryl stearate; one or more fatty compounds; and one or more triglycerides. The composition optionally comprises a hydrating agent and may be substantially free or free of one or more of petrolatum, mineral oil, and water. The compositions provide a occlusive and hydrating effect comparable to compositions comprising one or more of petrolatum, mineral oil, and lanolin.)

1. A protective barrier composition comprising:

(i) an emollient blend comprising glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate;

(ii) a surfactant comprising glyceryl stearate;

(iii) a plurality of fatty compounds comprising one or more fatty plant-derived or synthetic oils comprising one or more fatty chains having a chain length of C8 to C24 and including C8 and C24; and

(iv) one or more triglycerides present in the composition at a concentration ranging from about 20% to about 50% by weight, based on the total weight of the protective barrier composition.

2. The protective barrier composition of claim 1, wherein the emollient blend and the surfactant comprising glyceryl stearate are present in the composition in combination at a concentration up to and including about 30 wt% based on the weight of the protective barrier composition.

3. The protective barrier composition of claim 1, wherein the emollient blend comprises glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate present in a weight ratio of 1:1:1, based on the weight of the emollient blend.

4. The protective barrier composition of claim 1, wherein the emollient blend comprises glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate present in a weight ratio of about 3:2:1, based on the weight of the emollient blend.

5. The protective barrier composition of claim 1, wherein each of the emollient blend and the glyceryl stearate-containing surfactant is present in the composition at a concentration of at least about 2 wt% and up to about 20 wt%, based on the total weight of the protective barrier composition.

6. The protective barrier composition of claim 1, wherein the emollient blend is present in the composition at a concentration ranging from about 2% to about 20% by weight based on the total weight of the protective barrier composition.

7. The protective barrier composition of claim 1, wherein the surfactant comprising glyceryl stearate is present in the composition at a concentration in the range of about 2 wt% to about 20 wt%, based on the total weight of the protective barrier composition.

8. The protective barrier composition of claim 1, wherein the emollient blend and the surfactant comprising glyceryl stearate are present in a 1:1 weight ratio based on the weight of the protective barrier composition.

9. The protective barrier composition of claim 1, wherein the plurality of fatty compounds are present in the composition at a concentration of at least about 70 wt.%, based on the total weight of the protective barrier composition.

10. The protective barrier composition of claim 1, wherein the plurality of fatty compounds are present in the composition at a concentration ranging from about 70 wt.% to about 80 wt.% based on the total weight of the protective barrier composition.

11. The protective barrier composition of claim 1, comprising one or more of castor oil, hydrogenated vegetable oil, synthetic oil among the plurality of fatty compounds.

12. The protective barrier composition of claim 1, further comprising one or more of sweet almond oil and sunflower seed oil in the plurality of fatty compounds.

13. The protective barrier composition of claim 1, wherein the one or more triglycerides are present in the composition at a concentration ranging from about 25 wt.% to about 45 wt.%, based on the total weight of the protective barrier composition.

14. The protective barrier composition of claim 13, wherein the one or more triglycerides are selected from caprylic/capric triglyceride, triglycerides having a chain length of C10 to C18 and including C10 and C18, and combinations thereof.

15. The protective barrier composition of claim 1, comprising one or more hydrating agents present in the composition at a concentration ranging from about 10% to about 20% by weight, based on the total weight of the protective barrier composition.

16. The protective barrier composition of claim 15, comprising one or more hydrating agents selected from the group consisting of glycerin and squalane, and combinations thereof.

17. The protective barrier composition of claim 1, comprising one or more solvents present in the composition at a concentration ranging from about 1 wt.% to about 20 wt.% based on the total weight of the protective barrier composition.

18. The protective barrier composition of claim 17, comprising one or more solvents selected from glycols.

19. The protective barrier composition of claim 18, comprising one or more solvents selected from the group consisting of propylene glycol, caprylyl glycol, polypropylene glycol, and combinations thereof.

20. The protective barrier composition of claim 1 comprising one or more compounds selected from the group consisting of actives, vitamins, chelating agents, silicone oils, clays, conditioning agents, and combinations thereof.

21. The protective barrier composition of claim 20 comprising one or more of caprylylglycine, tocopherol, panthenol, sodium phytate, dimethicone, allantoin, dioctyl carbonate, and kaolin.

22. The protective barrier composition of claim 1, wherein the protective barrier composition is substantially free of one or more of petrolatum, mineral oil, and lanolin.

23. The protective barrier composition of claim 1, wherein the composition is substantially anhydrous.

24. A protective barrier composition comprising:

(i) an emollient blend comprising glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate;

(ii) a surfactant comprising glyceryl stearate;

wherein each of the emollient blend and the surfactant is present in the composition at a concentration in the range of from about 2 wt% to about 20 wt%, based on the total weight of the protective barrier composition, and wherein the combination of the emollient blend and the surfactant is present in the composition at a concentration of up to and including about 30 wt%, based on the total weight of the protective barrier composition;

(iii) a plurality of fatty compounds comprising one or more fatty plant-derived or synthetic oils comprising one or more fatty chains having a chain length from C8 to C24 and including C8 and C24, and present in the composition at a concentration of at least about 70 weight percent based on the total weight of the protective barrier composition; and

(iv) one or more triglycerides present in the composition at a concentration ranging from about 20% to about 50% by weight, based on the total weight of the protective barrier composition.

25. The protective barrier composition of claim 24, comprising one or more compounds selected from the group consisting of waxes, actives, vitamins, chelating agents, silicone oils, clays, conditioning agents, and combinations thereof.

26. The protective barrier composition of claim 25 comprising one or more of glycerin, caprylylglycine, panthenol, tocopherol, sodium phytate, dimethicone, allantoin, dioctyl carbonate, and kaolin.

27. The protective barrier composition of claim 24, wherein the protective barrier composition does not contain petrolatum, mineral oil, and lanolin, and is substantially anhydrous.

28. A protective barrier composition comprising:

(i) an emollient blend comprising glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate;

(ii) a surfactant comprising glyceryl stearate;

(iii) a plurality of fatty compounds, the plurality of fatty compounds comprising:

one or more of castor oil, hydrogenated vegetable oil, and hydrogenated polyisobutene;

one or more triglycerides selected from caprylic/capric triglyceride and triglycerides of chain length C10 to C18 and including C10 and C18, said one or more triglycerides being present in the composition at a concentration in the range of about 20% to about 50% by weight, based on the total weight of the protective barrier composition; and

one or more fatty compounds selected from sweet almond oil, sunflower seed oil; and

(iv) one or more hydrating agents;

wherein the protective barrier composition does not comprise water and one or more of petrolatum, mineral oil, and lanolin.

29. The protective barrier composition of claim 28, wherein the emollient blend is present in the composition in combination with the surfactant at a concentration of up to and including about 30 weight percent based on the total weight of the protective barrier composition, and wherein the plurality of fatty compounds are present in the composition at a concentration of at least about 70 weight percent based on the total weight of the protective barrier composition and comprise hydrogenated vegetable oil, hydrogenated polyisobutene, caprylic/capric triglyceride, one or a mixture of triglycerides each having a chain length of C10 to C18, sweet almond oil and sunflower seed oil.

30. The protective barrier composition of claim 29, further comprising one or more of a wax, an active, a vitamin, a chelating agent, a silicone oil, a clay, a conditioning agent, and combinations thereof.

31. The protective barrier composition of claim 30, further comprising one or more of glycerin, caprylylglycine, panthenol, tocopherol, sodium phytate, dimethicone, allantoin, dioctyl carbonate, and kaolin.

32. The protective barrier composition of claim 31, wherein the protective barrier composition does not comprise petrolatum, mineral oil, and lanolin, and is substantially anhydrous.

Technical Field

The present invention relates to protective barrier compositions that provide a protective occlusive barrier when applied to keratinous substrates, such as human skin and human hair.

Background

Topical formulations for keratinous substrates (e.g., skin) may include occlusive ingredients. The occlusive composition provides a barrier against water loss and against the ingress of irritants and contaminants. As is well known, occlusive compositions include hydrocarbons, such as in the form of petrolatum (petroleum jelly), and mineral oil, each of which has been included in a wide variety of skin and hair products. Such products are known for their spreadability texture and formability and for their effectiveness in preventing water loss and maintaining hydration of the skin and hair. Despite these beneficial characteristics, petrolatum, mineral oil, and lanolin may still have unpleasant tactile and aesthetic properties, including one or more of waxy, sticky, and warm feel. And these materials may present health and environmental concerns.

There is a need for a composition that overcomes one or more of the above-mentioned disadvantages associated with products that employ one or more of petrolatum, mineral oil, and lanolin. Such compositions will provide one or more of good spreadability, pleasant tactile and aesthetic properties and provide a protective barrier, e.g. to maintain hydration in skin and hair, to a degree at least comparable to products containing petrolatum and minerals.

Disclosure of Invention

The summary is provided to introduce a selection of concepts in a simplified form that are further described below in the detailed description of the invention. This summary is not intended to identify key features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter.

In various embodiments, the protective barrier composition and the method of making the protective barrier composition are characterized in that the protective barrier composition comprises: an emollient blend comprising glyceryl dibehenate, glyceryl tribehenate (tribehenin) and glyceryl behenate; a surfactant comprising glyceryl stearate; and a plurality of fatty compounds including one or more fatty plant-derived or synthetic oils comprising one or more fatty chains having a chain length of C8 to C24 and including C8 and C24; and one or more triglycerides.

In some embodiments, the emollient blend and the surfactant comprising glyceryl stearate are present in the composition in combination at a concentration up to and including about 30 weight percent, based on the weight of the protective barrier composition.

In some embodiments, the plurality of fatty compounds is present in the composition at a concentration of at least about 70 weight percent, based on the total weight of the protective barrier composition. In some particular embodiments, the plurality of fatty compounds is present in the composition at a concentration of about 70% to about 80% by weight, based on the total weight of the protective barrier composition.

In some embodiments, each of the emollient blend and the glyceryl stearate-containing surfactant is present in the composition at a concentration of at least 2 weight percent, based on the total weight of the protective barrier composition. In some embodiments, each of the emollient blend and the surfactant comprising glyceryl stearate is present in the composition at a concentration of from about 2% to about 20% by weight, based on the total weight of the protective barrier composition. In some embodiments, the emollient blend and the surfactant comprising glyceryl stearate are present in a 1:1 weight ratio, based on the weight of the protective barrier composition.

The one or more triglycerides may comprise one or more triglycerides, the one or combination being present in the composition at a concentration of between about 20 wt.% to about 50 wt.%, based on the total weight of the protective barrier composition. In some embodiments, the one or more triglycerides present in the plurality of fatty compounds are selected from caprylic/capric triglyceride, triglycerides having a chain length of C10 to C18 and including C10 and C18, and combinations thereof.

According to various embodiments, the protective barrier composition comprises one or more compounds selected from hydrating agents and solvents, and may further comprise any one or more, each of an active, a chelating agent, a silicone oil, a clay, a conditioning agent, combinations thereof, and other suitable additives.

In some embodiments, the protective barrier composition is substantially free or free of one or more of petrolatum, mineral oil, lanolin, and water. In some particular embodiments, the protective barrier composition is free of one or more of petrolatum, mineral oil, lanolin, and water. In some particular embodiments, the protective barrier composition is free of petrolatum, mineral oil, lanolin, and water. In some embodiments, the protective barrier composition is substantially free of water, except for trace amounts (i.e., water is present at a concentration of no more than 5 wt.% and more preferably no more than 1 wt.%, based on the weight of the composition). And in some embodiments, the protective barrier composition is substantially free or free of preservatives.

According to various embodiments, the composition provides a protective occlusive barrier to keratin tissue. In some examples, compositions lacking one or more of petrolatum, mineral oil, and lanolin exhibit physical properties, including viscosity, spreadability, rheology, comparable to products containing one or more of petrolatum, mineral oil, and lanolin.

Other features and advantages of the present invention will be apparent from the following more detailed description, taken in conjunction with the accompanying drawings, which illustrate, by way of example, the principles of the invention.

This disclosure describes particular embodiments only in accordance with the general inventive concept of the present invention and is not intended to limit the scope of the present invention in any way. Indeed, the invention described in this specification is broader than and unlimited by the specific embodiments set forth herein, and the terms used herein have their full ordinary meaning.

Detailed Description

As used herein, the term "occlusive barrier" means and refers to a composition that includes an agent that forms an occlusive barrier that minimizes or prevents water loss from the skin.

As used herein, the term "anhydrous" means that the composition is anhydrous in that water is not added as a component. In some embodiments, the composition is free of water. One skilled in the art will appreciate that water may be present in the composition via one or more of its presence in the formulation components, processing conditions, and absorption from the atmosphere; thus, in some embodiments, the composition may be "substantially anhydrous," wherein water is present at a concentration of no more than 5 weight percent and more preferably no more than 1 weight percent, based on the weight of the composition.

As used, the terms "petrolatum-free" and "mineral oil-free" mean that the composition lacks one or more of petrolatum, mineral oil, and lanolin. One skilled in the art will appreciate that one or more of petrolatum, mineral oil, and lanolin may be present in the composition via one or more of their presence in the formulation components and the processing conditions. Thus, in some embodiments, the composition may be "substantially free" of one or more of petrolatum, mineral oil, and lanolin, wherein the one or more of petrolatum, mineral oil, and lanolin is present at a concentration of no more than 5 weight percent, and more preferably no more than 1 weight percent, based on the weight of the composition. In some embodiments, one or more of petrolatum, mineral oil, and lanolin are not added as components in the composition. In some embodiments, the composition is free of one or more of petrolatum, mineral oil, and lanolin.

As used herein, the term "plant-derived oil" means a fatty plant-derived oil containing one or more fatty chains, and in some embodiments, fatty chains have a chain length of C8 to C24 and include C8 and C24. Thus, in some embodiments, the fat-derived vegetable oil may comprise one or a blend of oils having chain lengths of C8, C9, C10, C11, C12, C13, C14, C15, C16, C17, C18, C19, C20, C21, C22, C23, and C24.

As used herein, the term "triglyceride" means one or more of caprylic/capric triglyceride and triglyceride having a chain length of C10 to C18 and including C10 and C18. Thus, in some embodiments, the triglycerides may comprise one or a blend of triglycerides with chain lengths of C10, C11, C12, C13, C14, C15, C16, C17, and C18.

According to the present disclosure, there is provided a composition for providing a protective barrier, the composition comprising: an emollient blend comprising glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate; a surfactant comprising glyceryl stearate; and one or more fatty compounds including one or more fatty plant-derived or synthetic oils comprising one or more fatty chains having a chain length of C8 to C24 and including C8 and C24. In some embodiments, the composition comprises one or more triglycerides. In some embodiments, the composition comprises one or more of a hydrating agent, a solvent, an active, a vitamin, a chelating agent. In some embodiments, the protective barrier composition is substantially free or free of one or more of petrolatum, mineral oil, and lanolin. In some embodiments, the protective barrier composition is substantially free or free of water.

The composition provides occlusive properties when applied to the skin to help maintain a favorable environment for skin hydration and for skin healing. In some particular embodiments, the composition is free of petrolatum, mineral oil, and lanolin. The compositions provide the surprising and unexpected benefit of having a unique texture that mimics the thickness and spreadability of hydrocarbon and mineral oil based occlusive barrier products. Additionally, surprisingly, the occlusive and hydrating effect of the composition is comparable to a composition comprising one or more of petrolatum, mineral oil, and lanolin.

Emollient blends

In accordance with the present disclosure, there is provided a composition comprising an emollient blend comprising glyceryl dibehenate, glyceryl tribehenate and glyceryl behenate. According to various embodiments, the emollient blend comprises raw materials comprising glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate, which may each be provided in a solvent, either alone or when blended.

According to various embodiments, each of the emollient blend components glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate may be present in the composition in a weight ratio of from about 1:1 to about 3:1, based on the weight of the emollient blend. In other embodiments, the emollient blend comprises glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate present in a weight ratio of about 3:2:1, based on the weight of the emollient blend.

As used herein, glyceryl dibehenate is used to refer to a compound that is alternatively identified in the art as 2-hydroxypropane-1, 3-diylbis (behenate); 1,1' - (2-hydroxy-1, 3-propanediyl) behenate; 1, 3-behenic acid diglyceride (1, 3-dibehenin); 1-behenyloxy-3-behenyloxy-sn-glycerol; 1,2, 3-propanetriol 1, 3-dibehenate; 1-behenoyl-3-behenoyl-sn-glycerol; and diglycerides (22:0/0:0/22: 0). As used herein, glyceryl tribehenate is used to refer to a compound that is alternatively identified in the art as 1,2, 3-propanetriyl behenate; 1,2, 3-propanetriyl behenic acid; 1,2, 3-propanetriol tris (behenate) (1,2,3-propenetriol triodocosanoate); behenic acid 1,2, 3-propanetriyl ester; 1,2, 3-propanetriyl behenate; behenic acid 1,2,3 glyceryl triyl ester; glyceryl tribehenate; propane-1, 2, 3-triyltris (behenate); compritol 888; and docosanol (docosanin, tri- (7ci,8 ci)). Also, as used herein, glyceryl behenate is used to refer to a compound that is alternatively identified in the art as 2, 3-dihydroxypropyl behenate; 2, 3-dihydroxypropyl ester behenic acid; behenic acid monoglyceride; docoanoid, mono-; behenic acid 2, 3-dihydroxypropyl ester; monoesters of behenic acid and 1,2, 3-glycerol; glyceryl monobehenate; glycerol monobehenate; glyceryl monobehenate; mono-docosanoid; and monoesters of 1,2, 3-propanetriol and behenic acid.

Surface active agent

According to various embodiments, the emollient blend is present in the composition with one or more surfactants comprising glyceryl stearate, the combination being present in the composition at a concentration of up to and including about 30% by weight, based on the weight of the protective barrier composition. In some embodiments, the combination is present in an amount in a range of from about 1 wt% to about 30 wt%, or from about 1 wt% to about 25 wt%, or from about 1 wt% to about 10 wt%, or from about 1 wt% to about 7 wt%, or from about 2 wt% to about 6 wt%, or from about 3 wt% to about 5 wt%, or from about 5 wt% to about 15 wt%, or from about 6 wt% to about 10 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, based on the weight of the composition.

According to various embodiments, the surfactant may be present in the composition in a weight ratio of surfactant to emollient blend of from about 2:1 to about 1:2, based on the weight of the protective barrier composition. Thus, in some embodiments, the one or more surfactants comprising glyceryl stearate and the emollient blend may be present in a 1:1 weight ratio, based on the weight of the protective barrier composition.

According to various embodiments, the emollient blend is present in the composition at a concentration of at least about 2% by weight, based on the total weight of the protective barrier composition.

According to various embodiments, the emollient blend is present in the composition at a concentration, based on the total weight of the protective barrier composition, of: within a range of about 0.01 wt% to about 20 wt%, or about 2 wt% to about 20 wt%, or about 0.05 wt% to about 10 wt%, or about 0.1 wt% to about 4 wt%, or about 0.1 wt% to about 3.5 wt%, or about 0.7 wt% to about 1.5 wt%, or about 3.5 wt% to about 5 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, based on the weight of the composition.

Thus, the emollient blend is present in an amount of about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1,2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 weight percent to about 20 weight percent, based on the total weight of the composition, each or a combination, including increments and ranges therein and therebetween.

More particularly, each of glyceryl dibehenate, glyceryl tribehenate and glyceryl behenate is present in the composition at a concentration based on the total weight of the protective barrier composition as follows: within a range of about 0.01 wt% to about 20 wt%, or about 2 wt% to about 20 wt%, or about 0.05 wt% to about 10 wt%, or about 0.1 wt% to about 4 wt%, or about 0.1 wt% to about 3.5 wt%, or about 0.7 wt% to about 1.5 wt%, or about 3.5 wt% to about 5 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, based on the weight of the composition.

Thus, each of glyceryl dibehenate, glyceryl tribehenate, and glyceryl behenate is present in an amount of from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1,2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 weight percent to about 20 weight percent, based on the total weight, including increments and ranges therein and therebetween.

Fatty compounds

According to the present disclosure, a plurality of fatty compounds is present in the composition, the plurality of fatty compounds including one or more fatty plant-derived or synthetic oils comprising one or more fatty chains having a chain length of C8 to C24 and including C8 and C24. According to some embodiments, the fatty compound is selected from one or more of castor oil, hydrogenated vegetable oil, synthetic oil. According to some embodiments, the fatty compound is selected from one or more of castor (ricinus communis (castor)) seed oil, sweet almond (sweet almond)) oil, apricot (apricot) kernel oil, and sunflower (sunflower) seed oil.

In particular embodiments, the plurality of fatty compounds includes castor oil, hydrogenated vegetable oil, hydrogenated polyisobutene, sweet almond oil, and sunflower seed oil.

According to some embodiments, the plurality of fatty compounds comprises more than two fatty compounds.

According to various embodiments, the plurality of fatty compounds is present in the composition at a concentration, based on the weight of the composition, of: from about 1 wt% to about 95 wt%, or from about 50 wt% to about 95 wt%, or from about 70 wt% to about 90 wt%, or from about 70 wt% to about 80 wt%, or any suitable combination, sub-combination, range, or sub-range thereof.

According to some embodiments, the plurality of fatty compounds is present in the composition at a concentration of at least about 70% by weight, based on the total weight of the protective barrier composition. In some embodiments, the plurality of fatty compounds is present in an amount in a range of from about 70 wt% to about 95 wt%, or from about 70 wt% to about 90 wt%, or from about 70 wt% to about 80 wt%, or from about 72 wt% to about 75 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, based on the weight of the composition.

Thus, in some embodiments, the plurality of fatty compounds is present in an amount of about at least 70 weight percent, based on the total weight of the composition, to about 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, or 95 weight percent, including increments and ranges therein or therebetween, by weight.

According to various embodiments, each of the plurality of fatty compounds is present in the composition at a concentration, based on the total weight of the protective barrier composition, of: within a range of about 0.1 wt% to about 50 wt%, or about 0.5 wt% to about 50 wt%, or about 1 wt% to about 20 wt%, or about 2 wt% to about 20 wt%, or about 1.5 wt% to about 15 wt%, or about 1.5 wt% to about 10 wt%, or about 1.5 wt% to about 5 wt%, or about 1.5 wt% to about 2.5 wt%, or about 2.5 wt% to about 5 wt%, or about 4 wt% to about 10 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, based on the weight of the composition.

Thus, each or a combination of the plurality of fatty compounds is present in an amount of about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1,2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 22, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 weight percent to about 50 weight percent, including increments and ranges therein and there between, based on the total weight of the composition.

Triglycerides

According to the present disclosure, in some embodiments, the plurality of fatty compounds comprises one or more triglycerides. The triglycerides may include caprylic/capric triglyceride, triglycerides having chain lengths of C10 to C18 and including C10 and C18, and combinations thereof. Examples of C10 to C18 triglycerides include, for example, C10 triglycerides, C11 triglycerides, and the like.

In particular embodiments, the one or more triglycerides comprise caprylic/capric triglyceride and one or more triglycerides having a chain length of C10 to C18 and comprising C10 and C18.

According to various embodiments wherein the plurality of fatty compounds comprises one or more triglycerides, the one or more triglycerides are present in the composition at a concentration of between about 2 wt.% to about 50 wt.%, based on the total weight of the protective barrier composition. According to various embodiments, the one or more triglycerides are present in the composition at a concentration, based on the weight of the composition, of: from about 2 wt% to about 50 wt%, from about 2 wt% to about 40 wt%, or from about 10 wt% to about 40 wt%, or from about 20 wt% to about 35 wt%, or from about 22 wt% to about 35 wt%, or from about 25 wt% to about 45 wt%, or from about 30 wt% to about 45 wt%, or any suitable combination, sub-combination, range, or sub-range thereof.

In some embodiments, the composition comprises a plurality of triglycerides, the combination of the plurality of triglycerides present at a concentration of between about 20 wt.% to about 50 wt.%, based on the total weight of the protective barrier composition. According to such embodiments, each of the plurality of triglycerides is present in the composition at a concentration based on the total weight of the protective barrier composition as follows: within a range of about 1 wt% to about 40 wt%, or about 12 wt% to about 40 wt%, or about 3 wt% to about 30 wt%, or about 3 wt% to about 10 wt%, or about 5 wt% to about 35 wt%, or about 10 wt% to about 30 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, based on the weight of the composition.

Thus, on a weight basis, based on the total weight of the composition, each or a combination of triglycerides present in the plurality of fatty compounds is present in an amount of about 1,2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 22, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 weight percent to about 50 weight percent, including increments and ranges therein and therebetween.

Surface active agent

According to the present disclosure, the composition comprises one or more surfactants comprising glyceryl stearate. In some embodiments, the one or more surfactants may further comprise potassium stearate and/or sodium stearate. The composition may comprise other stearate based surfactant compounds.

As used herein, glyceryl stearate is used to refer to esters alternatively recognized in the art as octadecanoic acid with 1,2,3 glycerol; self-emulsifying glyceryl monostearate; and stearin (stearine).

According to various embodiments, the one or more surfactants comprising glyceryl stearate are present in the composition at concentrations, based on the weight of the composition, of: within a range of about 0.01 wt% to about 20 wt%, or about 2 wt% to about 20 wt%, or about 0.1 wt% to about 15 wt%, or about 0.1 wt% to about 5 wt%, or about 0.15 wt% to about 4 wt%, or about 0.5 wt% to about 3.5 wt%, or about 0.75 wt% to about 1.25 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, relative to the weight of the composition. In some embodiments, the one or more surfactants comprising glyceryl stearate are present in an amount of at least 0.01% or at least 2%. In some embodiments, one or more additional surfactants may be present in a composition according to the present disclosure.

Thus, the one or more surfactants comprising glyceryl stearate are present, either alone or in combination with another surfactant, in an amount of 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 weight percent to about 20 weight percent, including increments and ranges therein and therebetween, by weight, based on the total weight of the composition.

Hydrating agent

In accordance with the present disclosure, in some embodiments, one or more hydrating agents may be present in the composition. The hydrating agent may be selected from and include any one or more of synthetic hydrating agents and natural hydrating agents. Non-limiting examples of hydrating agents include glycerol, squalane, sucrose, triacetin, mono-ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, butylene glycol, dipropylene glycol, diethylene glycol, hexylene glycol, glycol ethers (such as monopropylene glycol, dipropylene glycol, and tripropylene glycol alkyl groups (C)₁-C₄) Ethers), glycerol, xylitol, maltitol, sorbitol, pentaerythritol, inositol, pyrrolidone carboxylic acid, lactic acid, lithium chloride, acetamide MEA, sodium lactate, urea, dicyandiamide, hyaluronic acid, aloe vera, honey, and seaweed extract.

In some particular embodiments, the composition comprises one or more hydrating agents selected from glycerol, squalane.

According to various embodiments, the one or more hydrating agents may be present in the composition in an amount in the range of from about 1% to about 20%, or from about 1% to about 15%, or from about 1% to about 10%, or from about 2% to about 5%, or from about 5% to about 20%, or from about 10% to about 20%, or from about 15% to about 20%, or any suitable combination, sub-combination, range, or sub-range thereof, by weight of the composition. In some embodiments, the one or more hydrating agents are present in an amount of at least 5%, or at least 10%, or at least 15%.

Thus, by weight, based on the total weight of the composition, one or a combination of hydrating agents can be present in an amount of each or a combination of about 1,2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 weight percent to about 20 weight percent, including increments and ranges therein and therebetween.

Solvent(s)

One or more solvents may be present in the composition in accordance with the present disclosure. According to some embodiments, the composition comprises one or more solvents comprising a glycol. As non-limiting examples, the glycol may be selected from and include glycerol, caprylyl glycol, propylene glycol, polyethylene glycol, and other glycols and combinations thereof.

In some particular embodiments, the one or more solvents comprise one or more of propylene glycol, caprylyl glycol, and polypropylene glycol.

According to various embodiments, the one or more solvents may be present in the composition in an amount in a range of from about 0.1 wt% to about 20 wt%, or from about 0.1 wt% to about 15 wt%, or from about 0.1 wt% to about 10 wt%, or from about 0.1 wt% to about 5 wt%, or from about 0.2 wt% to about 4 wt%, or from about 0.3 wt% to about 3 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, based on the weight of the composition.

Thus, by weight, based on the total weight of the composition, one or a combination of solvents may be present in an amount of each or the combination from about 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1,2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 weight percent to about 20 weight percent, including increments and ranges therein and therebetween.

Water (W)

According to various embodiments, the composition is substantially anhydrous or free of water.

Chelating agents

In accordance with the present disclosure, in some embodiments, one or more other components comprising a chelating agent may be present in a composition in accordance with the present disclosure. In some particular embodiments, the chelating agent is selected from the group consisting of sodium phytate, ethylenediaminetetraacetic acid (EDTA), tetrasodium etidronate, tetrasodium pyrophosphate, pentasodium ethylenediaminetetramethylenephosphonate, sodium citrate, and combinations thereof.

In some particular embodiments, the chelating agent comprises sodium phytate.

According to various embodiments, the chelating agent present in the composition according to the present disclosure may be present in the composition in an amount in the range of from about 0.01 wt% to about 5 wt%, or from about 0.05 wt% to about 2 wt%, or from about 0.10 wt% to about 1 wt%, or from about 0.15 wt% to about 0.5 wt% and from about 0.15 wt% to about 0.2 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, based on the weight of the composition.

Thus, on a weight basis, one or a combination of chelating agents can be present in an amount of about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2.0, 3.0, 4.0 weight percent to about 5.0 weight percent, including increments and ranges therein and therebetween, of each or a combination.

Active substance

In accordance with the present disclosure, in some embodiments, one or more actives may be present in a cosmetic composition. In some embodiments, the actives used according to the present disclosure may be selected from: antimicrobial components including, but not limited to, capryloyl glycine and sodium salicylate; antioxidants, including, but not limited to, phenolic compounds such as chalcones, flavonoids, flavanones, flavanols, flavanonols, isoflavones, neoflavonoids, catechins, anthocyanins, tannins, lignans, auranones, stilbenes, curcuminoids, alkylphenols, betacyanins, capsaicins, hydroxybenzophenones, methoxyphenols, naphthoquinones, phenolic terpenes, resveratrol, curcumin, pinoresinol, ferulic acid, hydroxytyrosol, cinnamic acid, caffeic acid, p-coumaric acid, baicalin, pine bark extract, ellagic acid; and vitamins and vitamin derivatives such as panthenol, tocopherol, ascorbic acid; conditioning agents such as silicone oil, dimethicone, allantoin, and dioctyl carbonate; clays, such as kaolin; and combinations thereof. While the above-mentioned optional components are given as examples, it will be appreciated that other optional components known in the art to be compatible with cosmetic applications may be used.

In some particular embodiments, the active is selected from caprylylglycine, panthenol, and tocopherol; one or a combination of dimethicone, allantoin, dioctyl carbonate and kaolin.

According to various embodiments, one or more actives present in the compositions, alone or in combination, may be present in the compositions according to the present disclosure in an amount in the range of from about 0.01 wt% to about 20 wt%, or from about 0.05 wt% to about 15 wt%, or from about 0.1 wt% to about 10 wt%, or from about 0.15 wt% to about 5 wt%, or from about 0.40 wt% to about 4 wt%, or from about 0.50 wt% to about 2 wt%, or from about 1 wt% to about 2 wt%, or any suitable combination, sub-combination, range, or sub-range thereof, based on the weight of the composition.

Thus, by weight, based on the total weight of the composition, one or a combination of the actives may be present in an amount of from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 weight percent to about 20 weight percent, including increments and ranges therein and therebetween.

Raw material

Compositions as described in representative embodiments according to the present disclosure, and as exemplified herein, comprise raw materials selected from commercially available materials, including for example: a blend of glyceryl dibehenate & glyceryl tribehenate & glyceryl behenate; glyceryl stearate; hydrogenated castor oil; glyceryl dibehenate-all RMs 100% unless otherwise stated.

Examples

Compositions of the invention

Comparative compositions

Aquaphor:

Active ingredients: petrolatum (41%); inactive ingredients: mineral oil, ceresin, lanolin alcohol, panthenol, glycerol, and bisabolol

Aqua Baume: silicone and aqueous emulsion

Inventive and comparative testing:

the transdermal water loss (TEWL) can be determined in a bench top system (simulating live skin) that evaluates the skin barrier properties of the test compositions. The TEWL test may include the use of an automated system that measures the amount of water lost from the chamber through the treated membrane under controlled temperature and humidity for extended periods of time. According to the method, a fixed volume of water is deposited in each chamber, and a fixed amount of each test composition is applied to the membrane of each respective test chamber. The lower the TEWL water loss flux value, the less water loss through the skin is expected and thus the greater the occlusive barrier protection.

Test results were obtained for compositions of the invention comprising an emollient composition, together with a surfactant and a fatty compound, which showed comparable performance to mineral oil based compositions. As expected, the Aqua Baume control lacking the blocking component (265 g m) was utilized^-2h^-1) Maximum water loss was observed. These test results show that the inventive compositions comprising the emollient composition according to the present disclosure, a surfactant and a fatty compound provide a surprisingly comparable occlusive barrier to that provided by conventional mineral oil-based compositions.

As used herein, the article "a" or "an" when applied to any feature of embodiments described in the specification and claims of the present invention means one or more. The use of "a/an" does not limit the meaning to a single feature unless such a limitation is specifically stated. The article "the" preceding singular or plural nouns or noun phrases denotes a particular specified feature or particular specified features and may have a singular or plural connotation depending upon the context in which it is used. The adjective "any" means, indiscriminately, any number of one, some, or all.

As used herein, "one or more" means at least one and thus includes individual components as well as mixtures/combinations.

The transitional terms "comprising," "consisting essentially of," and "consisting of," when used in the appended claims in both original and amended form, are intended to be excluded from the scope of the claims, as defined by the recitations of additional claim elements or steps, if any, not otherwise recited. The term "comprising" is intended to be inclusive or open-ended and does not exclude any additional unrecited elements, methods, steps or materials. The term "consisting of" excludes any element, step, or material other than those specified in the claims, and in the latter case excludes ordinary impurities associated with the specified material. The term "consisting essentially of" limits the scope of the claims to the specified elements, steps or materials and those that do not materially affect the basic and novel characteristics of the claimed invention. In alternative embodiments, all of the materials and methods described herein that embody the present invention may be more specifically defined by any of the transitional terms "comprising," consisting essentially of, "and" consisting of.

Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of ingredients and/or reaction conditions are to be understood as being modified in all instances by the term "about," meaning within 10% of the number indicated (e.g., "about 10%" means 9% to 11% and "about 2%" means 1.8% to 2.2%).

All percentages and ratios are calculated by weight unless otherwise indicated. All percentages are calculated based on the total composition, unless otherwise indicated. Generally, "weight" or "amount" as used herein with respect to a percentage amount of an ingredient refers to the amount of raw material that comprises the ingredient, wherein the raw material may be described herein as comprising less than and as high as the 100% activity, unless expressly stated otherwise herein. Thus, the weight percent of active in the composition is expressed as the amount of raw material containing the active used, and may or may not reflect the final percent of active, where the final percent of active depends on the weight percent of active in the raw material.

All ranges and amounts given herein are intended to include subranges and amounts using any of the disclosed points as endpoints. Thus, ranges of "1% to 10%, such as 2% to 8%, such as 3% to 5%" are intended to encompass "1% to 8%", "1% to 5%", "2% to 10%", and the like. All numbers, amounts, ranges, etc. are intended to be modified by the term "about," whether or not explicitly stated. Similarly, a range of "about 1% to 10%" is given with the intent that the term "about" modifies the endpoints of 1% and 10%. Further, it is understood that when amounts of components are given, amounts of active materials are intended unless specifically stated otherwise.

Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the disclosure are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements. The following examples are intended to illustrate embodiments of the present disclosure, but are not limiting in nature.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments falling within the scope of the appended claims.