阅读说明：本技术 一种核磁共振校准用水模灌装液及其制备方法 (Water mold filling liquid for nuclear magnetic resonance calibration and preparation method thereof ) 是由 刘人生 于 2021-01-04 设计创作，主要内容包括：本申请涉及磁共振技术领域,具体公开了一种核磁共振校准用水模灌装液及其制备方法。灌装液包括氯化钠、硫酸镍、硫酸铜、防腐剂、去离子水；其制备方法为：步骤一、在去离子水中缓慢加入氯化钠,搅拌至全部溶解,随后加入硫酸镍、硫酸铜和防腐剂,即得预混液；步骤二、将预混液利用高温蒸汽设备灭菌,控制压力为104 kPa-135kPa,温度为120℃-130℃,灭菌时间为15min-30min,即得水模灌装液。本申请利用硫酸镍、硫酸铜和氯化镍降低灌装液体系的介电常数,从而可以调高灌装液体系的电导率,使灌装液的电导率和射频贴近人体组织液的电导率和射频,偏差较小,核磁共振校准的准确性提高。(The application relates to the technical field of magnetic resonance, and particularly discloses a water model filling liquid for nuclear magnetic resonance calibration and a preparation method thereof. The filling liquid comprises sodium chloride, nickel sulfate, copper sulfate, preservative and deionized water; the preparation method comprises the following steps: step one, slowly adding sodium chloride into deionized water, stirring until the sodium chloride is completely dissolved, and then adding nickel sulfate, copper sulfate and a preservative to obtain a premixed solution; and step two, sterilizing the premixed liquid by using high-temperature steam equipment, controlling the pressure to be 104-135 kPa, the temperature to be 120-130 ℃, and sterilizing for 15-30 min to obtain the water mold filling liquid. The method utilizes nickel sulfate, copper sulfate and nickel chloride to reduce the dielectric constant of the filling liquid system, so that the conductivity of the filling liquid system can be increased, the conductivity and the radio frequency of the filling liquid are close to those of human tissue fluid, the deviation is small, and the accuracy of nuclear magnetic resonance calibration is improved.)

1. The water mold filling liquid for nuclear magnetic resonance calibration is characterized by comprising the following raw materials in parts by weight:

sodium chloride: 48-58 parts;

nickel sulfate: 2.7-4.2 parts;

copper sulfate: 1.6 to 2.4 portions;

preservative: 1.5-2.6 parts;

deionized water: 1000 parts.

2. The water mold filling liquid for nuclear magnetic resonance calibration according to claim 1, characterized in that: the preservative is potassium sorbate.

3. The water mold filling liquid for nuclear magnetic resonance calibration according to claim 1, characterized in that: the raw material components also comprise 35 to 57 weight parts of cane sugar and 24 to 41 weight parts of hydroxyethyl cellulose, and the purity of the cane sugar is more than 98 percent.

4. The water mold filling liquid for nuclear magnetic resonance calibration according to claim 3, wherein the mass ratio of the sucrose to the hydroxyethyl cellulose is 5: 3.

5. The water mold filling liquid for nuclear magnetic resonance calibration according to claim 1 or 3, wherein the raw material components further comprise 26 to 43 parts by weight of dimethylene glycol butyl ether.

6. The water mold filling liquid for nuclear magnetic resonance calibration according to claim 1, characterized by comprising the following raw materials in parts by weight:

sodium chloride: 48 parts of a mixture;

nickel sulfate: 4.2 parts of a mixture;

copper sulfate: 2.1 parts;

potassium sorbate: 2.2 parts of;

dimethylene glycol butyl ether: 43 portions of

Sucrose: 50 parts of a mixture;

hydroxyethyl cellulose: 30 parts of (1);

deionized water: 1000 parts of (A);

wherein the purity of the sucrose is greater than 98%.

7. A preparation method of a water model filling liquid for nuclear magnetic resonance calibration, which is based on any one of claims 1 to 6, is characterized by comprising the following steps:

step one, slowly adding sodium chloride into deionized water, stirring until the sodium chloride is completely dissolved, then adding nickel sulfate, copper sulfate and a preservative, mixing and stirring uniformly, and scraping white foam on the surface of a liquid by using a strainer to obtain a premixed liquid;

and step two, sterilizing the premixed liquid by using high-temperature steam equipment, controlling the pressure to be 104-135 kPa, the temperature to be 120-130 ℃, and sterilizing for 15-30 min to obtain the water mold filling liquid.

8. The method for preparing the water mold filling liquid for nuclear magnetic resonance calibration according to claim 7, wherein in the first step, 35 to 57 parts by weight of sucrose and 24 to 41 parts by weight of hydroxyethyl cellulose are further added as raw material components, and the sucrose and the hydroxyethyl cellulose are added simultaneously with nickel sulfate, copper sulfate and a preservative.

9. The method for preparing water mold filling liquid for nuclear magnetic resonance calibration according to claim 7 or 8, wherein in the first step, 26 to 43 parts by weight of dimethylene glycol butyl ether is further added as raw material components, and the dimethylene glycol butyl ether is added simultaneously with nickel sulfate, copper sulfate and preservative.

Technical Field

The application relates to the technical field of magnetic resonance, in particular to a water model filling liquid for nuclear magnetic resonance calibration and a preparation method thereof.

Background

Magnetic resonance imaging uses the long T2 characteristic of water, the T2 value of static or slow flowing liquid in vivo is far greater than that of other tissues, and the transverse magnetization vector of other tissues is almost completely attenuated, the signal intensity is low, even almost no signal is generated by using a heavy T2 sequence with the heavy weight of T2, and the water still keeps a larger transverse magnetization vector, so that the hydrous organ is developed.

In the actual imaging process, the static magnetic field of the nuclear magnetic resonance system is not absolutely uniform, and due to the entrance of the human body, the different magnetic susceptibility of the human tissue further makes the static magnetic field nonuniform, resulting in different precession frequencies of protons in the human body. Therefore, the center frequency of the magnetic resonance system needs to be calibrated to a proper value when performing the nuclear magnetic resonance scan to ensure that a high quality magnetic resonance image is obtained.

The water model filled with the human tissue fluid simulation liquid is adopted to replace a human body for frequency calibration, and the deviation of the conductivity and the radio frequency value of the simulation liquid filled in the water model and the human tissue fluid is large. In the nuclear magnetic resonance process, the central frequency of the magnetic resonance system has deviation from the optimal central frequency during actual human tissue scanning, so that the magnetic resonance image of the scanned human body is inaccurate.

Disclosure of Invention

In order to improve the calibration accuracy of the water model and improve the imaging accuracy of nuclear magnetic resonance, the application provides the water model filling liquid for nuclear magnetic resonance calibration and the preparation method thereof.

In a first aspect, the application provides a water mold filling liquid for nuclear magnetic resonance calibration, which adopts the following technical scheme:

a water mold filling liquid for nuclear magnetic resonance calibration comprises the following raw materials in parts by weight:

sodium chloride: 48-58 parts;

nickel sulfate: 2.7-4.2 parts;

copper sulfate: 1.6 to 2.4 portions;

preservative: 1.5-2.6 parts;

deionized water: 1000 parts.

By adopting the technical scheme, the dielectric constant of water is high and the conductivity is lower, the dielectric constant of the filling liquid system is reduced by utilizing nickel sulfate, copper sulfate and nickel chloride, the imaginary part of the dielectric constant is increased, and the insulating property is reduced, so that the conductivity of the filling liquid system can be increased, the conductivity and the radio frequency of the filling liquid are close to the conductivity and the radio frequency of human tissue fluid, the deviation is smaller, and the accuracy of nuclear magnetic resonance calibration is improved; the copper sulfate and the preservative have the bacteriostatic effect, so that the components of the filling liquid can be prevented from changing, the service cycle is prolonged, and the conductivity and the radio frequency stability of a filling liquid system are ensured.

Preferably, the preservative is potassium sorbate.

By adopting the technical scheme, the potassium sorbate can effectively inhibit the propagation of microorganisms such as mould, aerobic bacteria, staphylococcus and the like, has the functions of sterilization and antibiosis, can improve the corrosion resistance of the filling liquid, prolongs the service cycle, avoids the change of the ingredients of the filling liquid due to the deterioration of the ingredients in the filling liquid, and ensures the conductivity and the radio frequency stability of the filling liquid.

Preferably, the raw material components also comprise 35 to 57 parts by weight of sucrose and 24 to 41 parts by weight of hydroxyethyl cellulose, and the purity of the sucrose is more than 98 percent.

By adopting the technical scheme, the dielectric constant of the filling liquid system is reduced by adopting the sucrose, the fluctuation of the dielectric constant of the sucrose adjusting system is slow and stable, the overlarge deviation between the conductivity of the filling liquid system and the conductivity of human tissue fluid in the adjusting process is prevented, the sucrose is high in stability under the high-temperature condition and is not easy to carbonize, the sucrose does not belong to energy directly absorbed and utilized by microorganisms, the pollution of the microorganisms can be reduced, the material components in the filling liquid are stable, the calibration accuracy of nuclear magnetic resonance is improved, the saturation of the sucrose in the filling liquid system can be reduced by the hydroxyethyl cellulose, and the solubility is improved.

Preferably, the mass ratio of the sucrose to the hydroxyethyl cellulose is 5: 3.

By adopting the technical scheme, the mass ratio of the sucrose to the hydroxyethyl fiber is adjusted to be 5:3, so that the solubility of the sucrose is improved, the sucrose can accurately adjust the dielectric constant of the filling liquid system, the conductivity and the radio frequency value of the filling liquid system can be matched with those of human tissue fluid, and the nuclear magnetic resonance detection accuracy is improved.

Preferably, the raw material components also comprise 26 to 43 parts by weight of dimethylene glycol butyl ether.

By adopting the technical scheme, the dimethylene glycol butyl ether is added into the filling liquid, so that the conductivity and the radio frequency of the filling liquid system can be adjusted, the conductivity and the radio frequency of the filling liquid system are close to the conductivity and the radio frequency value of human tissue fluid, the deviation is reduced, and the accuracy of nuclear magnetic resonance scanning images is improved.

Preferably, the filling liquid comprises the following raw materials in parts by weight:

sodium chloride: 48 parts of a mixture;

nickel sulfate: 4.2 parts of a mixture;

copper sulfate: 2.1 parts;

potassium sorbate: 2.2 parts of;

dimethylene glycol butyl ether: 43 portions of

Sucrose: 50 parts of a mixture;

hydroxyethyl cellulose: 30 parts of (1);

deionized water: 1000 parts of (A);

wherein the purity of the sucrose is greater than 98%.

By adopting the technical scheme, the dielectric constant in the filling liquid obtained by the scheme is close to that of human tissue fluid to the maximum extent, the deviation between the conductivity and the radio frequency value of the filling liquid and the conductivity and the radio frequency value of the human tissue fluid is small, and the accuracy of nuclear magnetic resonance calibration can be improved.

In a second aspect, the application provides a preparation method of a water mold filling liquid for nuclear magnetic resonance calibration, which adopts the following technical scheme:

a preparation method of a water mold filling liquid for nuclear magnetic resonance calibration comprises the following steps:

step one, slowly adding sodium chloride into deionized water, stirring until the sodium chloride is completely dissolved, then adding nickel sulfate, copper sulfate and a preservative, mixing and stirring uniformly, and scraping white foam on the surface of a liquid by using a strainer to obtain a premixed liquid;

and step two, sterilizing the premixed liquid by using high-temperature steam equipment, controlling the pressure to be 104-135 kPa, the temperature to be 120-130 ℃, and sterilizing for 15-30 min to obtain the water mold filling liquid.

By adopting the technical scheme, the sodium chloride is dissolved in the deionized water in advance, so that the solubility of the sodium chloride can be improved, other components of the filling liquid are mixed with the deionized water to form a solution, the solution is sterilized at high temperature, microorganisms in a filling liquid system are taken out, the microorganisms are prevented from being propagated and metabolized in the filling liquid, the components of the filling liquid are changed, and the service cycle of the water model and the stability of the conductivity and the radio frequency value of the water model are improved.

Preferably, in the step one, the raw material components are further added with 35 to 57 parts by weight of sucrose and 24 to 41 parts by weight of hydroxyethyl cellulose, and the sucrose and the hydroxyethyl cellulose are added with nickel sulfate, copper sulfate and a preservative synchronously.

By adopting the technical scheme, the hydroxyethyl cellulose can reduce the saturation of the sucrose in the filling liquid system, improve the solubility, reduce the dielectric constant of the filling liquid system by adopting the sucrose, and slowly and stably regulate the fluctuation of the dielectric constant of the system, so that the overlarge deviation between the conductivity of the filling liquid system and the conductivity of the human tissue fluid in the regulation process is prevented, and the accuracy of nuclear magnetic resonance calibration is improved.

Preferably, in the first step, 26 to 43 parts by weight of dimethylene glycol butyl ether is further added to the raw material components, and the dimethylene glycol butyl ether is added with nickel sulfate, copper sulfate and a preservative simultaneously.

By adopting the technical scheme, the dimethylene glycol butyl ether can adjust the conductivity and the radio frequency of a filling liquid system, reduce the deviation and further improve the accuracy of a nuclear magnetic resonance scanning image.

In summary, the present application has the following beneficial effects:

1. the dielectric constant of water is high, the conductivity of the water is low, the dielectric constant of the filling liquid system is reduced by utilizing nickel sulfate, copper sulfate and nickel chloride, the imaginary part of the dielectric constant is increased, and the insulating property is reduced, so that the conductivity of the filling liquid system can be increased, the conductivity and the radio frequency of the filling liquid are close to the conductivity and the radio frequency of human tissue liquid, the deviation is small, and the accuracy of nuclear magnetic resonance calibration is improved; the copper sulfate and the preservative have the bacteriostatic effect, so that the components of the filling liquid can be prevented from changing, the service cycle is prolonged, and the conductivity and the radio frequency stability of a filling liquid system are ensured.

2. The sucrose is adopted to reduce the dielectric constant of the filling liquid system, the fluctuation of the dielectric constant of the sucrose adjusting system is slow and stable, the overlarge deviation between the conductivity of the filling liquid system and the conductivity of human tissue fluid in the adjusting process is prevented, the sucrose is high in stability under the high-temperature condition and not easy to carbonize, the sucrose does not belong to energy directly absorbed and utilized by microorganisms, the pollution of the microorganisms can be reduced, the material components in the filling liquid are stable, the calibration accuracy of nuclear magnetic resonance is improved, the hydroxyethyl cellulose can reduce the saturation of the sucrose in the filling liquid system, and the solubility is improved.

3. The sodium chloride is dissolved in the deionized water in advance, so that the solubility of the sodium chloride can be improved, other components of the filling liquid are mixed with the deionized water to form a solution, the solution is sterilized at high temperature, microorganisms in a filling liquid system are taken out, the microorganisms are prevented from being propagated and metabolized in the filling liquid, the components of the filling liquid are changed, and the service cycle of the water model and the stability of the conductivity and the radio frequency value of the water model are improved.

Detailed Description

The present application will be described in further detail with reference to examples.

The sources and types of the raw materials in the examples are as follows:

the nickel sulfate is sold by chemical product company Limited of Xin of Henan Ming;

the copper sulfate is sold by chemical product company Limited of Xin of Ming of Henan;

the ferric sulfate is sold by chemical product company Limited of Xin of Ming of Henan;

the Kathon is sold by Jinan Jiufang new material science and technology limited;

the sodium sulfite is sold by Ordovician chemical industry Co.Ltd;

the potassium cinnamate is potassium cinnamate sold by Wuhan Brilliant biotechnology limited company;

the hydroxyethyl cellulose is sold by Zhengzhou Yu and food additive limited company;

the diethylene glycol butyl ether was sold by International trade company GmbH, Panasia, Tandon Paoyi, Zhang.

Examples

Examples 1 to 3

A water mold filling liquid for nuclear magnetic resonance calibration is prepared by the following steps:

step one, slowly adding sodium chloride into deionized water, stirring until the sodium chloride is completely dissolved, then adding nickel sulfate, copper sulfate and a preservative, mixing and stirring uniformly, and scraping white foam on the surface of the liquid by using a strainer to obtain a premixed liquid, wherein the resistance of the deionized water is greater than or equal to 16M ohm;

and step two, sterilizing the premixed liquid by using high-temperature steam equipment, controlling the pressure under the condition of the pressure value shown in the table 1, controlling the temperature under the condition of the temperature value shown in the table 1, and controlling the sterilization time under the condition shown in the table 1 to obtain the water mold filling liquid.

TABLE 1-Components, amounts and Process parameters of examples 1-3

Example 4

A water-mold filling liquid for nuclear magnetic resonance calibration, which is different from the liquid in example 3 in that potassium cinnamate is replaced by potassium sorbate.

Example 5

The difference of the water model filling liquid for nuclear magnetic resonance calibration from the embodiment 3 is that in the step one, 35g of cane sugar and 24g of hydroxyethyl cellulose are added in parts by weight, the purity of the cane sugar is more than 98%, and the cane sugar, the hydroxyethyl cellulose, nickel sulfate, copper sulfate and potassium cinnamate are synchronously added.

Example 6

The difference between the water model filling liquid for nuclear magnetic resonance calibration and the embodiment 3 is that in the step one, the raw material components are added with 57g of cane sugar and 41g of hydroxyethyl cellulose in parts by weight, the purity of the cane sugar is more than 98%, and the cane sugar, the hydroxyethyl cellulose, the nickel sulfate, the copper sulfate and the potassium cinnamate are synchronously added.

Example 7

The difference of the water model filling liquid for nuclear magnetic resonance calibration from the embodiment 3 is that in the step one, 26g of dimethylene glycol butyl ether is added as raw material components, and the dimethylene glycol butyl ether, nickel sulfate, copper sulfate and preservative are synchronously added.

Example 8

The difference of the water model filling liquid for nuclear magnetic resonance calibration from the embodiment 3 is that in the step one, 43g of dimethylene glycol butyl ether is added as raw material components, and the dimethylene glycol butyl ether, nickel sulfate, copper sulfate and preservative are synchronously added.

Example 9

The difference of the water model filling liquid for nuclear magnetic resonance calibration from the embodiment 3 is that in the step one, the raw material components are further added with 57g of sucrose, 41g of hydroxyethyl cellulose and 43g of dimethylene glycol butyl ether in parts by weight, the purity of the sucrose is more than 98%, and the sucrose, the hydroxyethyl cellulose and the dimethylene glycol butyl ether are synchronously added with nickel sulfate, copper sulfate and potassium cinnamate.

Example 10

The water mold filling liquid for nuclear magnetic resonance calibration is different from the water mold filling liquid in example 6 in that the content of sucrose is 40g, the content of hydroxyethyl cellulose is 24g, and the mass ratio of the sucrose to the hydroxyethyl cellulose is 5: 3.

Example 11

The water mold filling liquid for nuclear magnetic resonance calibration is different from the water mold filling liquid in example 6 in that the content of sucrose is 50g, the content of hydroxyethyl cellulose is 30g, and the mass ratio of the sucrose to the hydroxyethyl cellulose is 5: 3.

Example 12

A water mold filling liquid for nuclear magnetic resonance calibration is prepared by the following steps:

step one, slowly adding 48g of sodium chloride into 1000g of deionized water, stirring until the sodium chloride is completely dissolved, then adding 50g of sucrose, 30g of hydroxyethyl cellulose, 4.2g of nickel sulfate, 2.1g of copper sulfate, 2.2g of potassium sorbate and 43g of dimethylene glycol butyl ether, mixing and stirring uniformly, and removing white foam on the surface of a liquid by using a strainer to obtain a premixed solution, wherein the resistance of the deionized water is more than or equal to 16M ohm, and the purity of the sucrose is more than 98%;

and step two, sterilizing the premixed liquid by using high-temperature steam equipment, controlling the pressure to be 135kPa, controlling the temperature to be 130 ℃, and controlling the sterilization time to be 25min to obtain the water mold filling liquid.

Comparative example

Comparative example 1

A water mold filling liquid for nuclear magnetic resonance calibration is prepared by the following steps: stirring and mixing 1000g of deionized water and 75g of sodium chloride uniformly to obtain the water model filling liquid.

Comparative example 2

A water mold filling liquid for nuclear magnetic resonance calibration, which is different from the liquid in the embodiment 3 in that nickel sulfate and copper sulfate are both replaced by ferric sulfate.

Performance test

According to the international standard IEC62209-2, the conductivity of the simulated fluid and the radio frequency signal of the human tissue fluid should be as close as possible to those of the human tissue fluid, and the deviation should be controlled within +/-5% of the standard value;

collecting 50 groups of fresh human blood samples, controlling the temperature of a sample solution within 22 +/-2 ℃, detecting the conductivity by using a conductivity instrument at the frequency of 5.4GHz, and calculating the average value of the conductivity to obtain the standard conductivity; detecting radio frequency by using a vector analyzer, calculating a radio frequency average value to obtain a standard radio frequency value, and preparing to obtain a human tissue fluid sample;

testing of conductivity: preparing water mold filling liquid samples by adopting the methods of examples 1-12 and comparative examples 1-2, standing overnight to stabilize the liquid, controlling the temperature of the sample solution within 22 +/-2 ℃, and detecting the conductivity of the samples of examples 1-12 and comparative examples 1-2 by using a conductivity instrument at the frequency of 5.4GHz, wherein the test results are shown in Table 2;

the calculation formula of the conductivity deviation (%) is: the calculated results are shown in table 2, where the conductivity deviation is (filling liquid conductivity-standard conductivity)/standard conductivity × 100;

and (3) testing the radio frequency: preparing water mold filling liquid samples by adopting the methods of examples 1-12 and comparative examples 1-2, standing overnight to stabilize the liquid, controlling the temperature of the sample solution within 22 +/-2 ℃, and detecting the radio frequency (dB) of the samples of examples 1-12 and comparative examples 1-2 by using a vector analyzer, wherein the test results are shown in Table 2;

the radio frequency deviation (%) is calculated as: the radio frequency deviation (filling liquid radio frequency-standard radio frequency value)/standard radio frequency value × 100, and the calculation results are shown in table 2.

TABLE 2 summary of test data for examples 1-12 and comparative example 1

Detecting items	Electrical conductivity of	Deviation in conductivity (%)	Radio frequency (dB)	Radio frequency deviation (%)
					Example 1	4.97	3.11	66.8	2.45
Example 2	4.68	-2.90	66.4	1.84
					Example 3	4.72	-2.07	66.3	1.69
Example 4	4.73	-1.87	66.1	1.38
					Example 5	4.76	-1.24	65.8	0.92
Example 6	4.77	-1.04	65.7	0.77
					Example 7	4.75	-1.45	65.9	1.07
Example 8	4.76	-1.24	65.8	0.92
					Example 9	4.78	-0.83	65.5	0.46
Example 10	4.78	-0.83	65.5	0.46
					Example 11	4.79	-0.62	65.5	0.46
Example 12	4.81	-0.21	65.3	0.15
					Comparative example 1	5.23	8.51	61.8	-5.21
Comparative example 2	4.56	-5.39	68.5	5.06
					Human tissue fluid standard sample	4.82	——	65.2	——

According to comparison of test data results of the example 3 and the comparative examples 1-2 in the table 2, the dielectric constant of water is high, the conductivity of water is low, the dielectric constant of the filling liquid system is reduced by using nickel sulfate, copper sulfate and nickel chloride, the imaginary part of the dielectric constant is increased, and the insulating property is reduced, so that the conductivity of the filling liquid system can be increased, the conductivity and the radio frequency of the filling liquid are close to those of human tissue liquid, the deviation is small, and the accuracy of nuclear magnetic resonance calibration is improved.

According to the comparison of the test data of the examples 3-4 in the table 2, the potassium sorbate can effectively inhibit the propagation of microorganisms such as mold, aerobic bacteria, staphylococcus and the like, has the functions of sterilization and antibiosis, can improve the corrosion resistance of the filling liquid, prolong the service life, avoid the change of the components of the filling liquid due to the deterioration of the components in the filling liquid, and ensure the conductivity and the radio frequency stability of the filling liquid.

According to comparison of test data of examples 3 and 5-6 in table 2, it can be known that sucrose is used to reduce the dielectric constant of the filling liquid system, and the fluctuation of the dielectric constant of the sucrose regulation system is slow and stable, so that the phenomenon that the deviation between the conductivity of the filling liquid system and the conductivity of human tissue fluid is too large in the regulation process is prevented.

According to comparison of test data of examples 3 and 7-8 in table 2, the electrical conductivity and radio frequency of the filling liquid system can be adjusted by adding the dimethylene glycol butyl ether into the filling liquid, so that the electrical conductivity and radio frequency of the filling liquid system are close to the electrical conductivity and radio frequency value of human tissue liquid, the deviation is reduced, and the accuracy of nuclear magnetic resonance scanning images is improved.

According to comparison of test data of examples 6 and 10-11 in table 2, the solubility of sucrose is improved by adjusting the mass ratio of sucrose to hydroxyethyl fiber to be 5:3, the sucrose can accurately adjust the dielectric constant of the filling liquid system, the conductivity and the radio frequency value of the filling liquid system can be matched with those of human tissue liquid, and the accuracy of nuclear magnetic resonance detection is improved.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.