阅读说明：本技术 一种用于银屑病实验研究装置及其使用方法 (Psoriasis experimental research device and using method thereof ) 是由 欧阳厚淦 陈楚 谢斌 卢文静 吴慧婷 易岚 齐艳喆 朱绪映 于 2020-12-15 设计创作，主要内容包括：本发明公开了一种用于银屑病实验研究装置及其使用方法,其包括主筒体和控制盒,主筒体通过伸缩杆连接在控制盒的上端,主筒体的前侧连接头筒,主筒体的后端连接尾巴固定杆,控制盒的内部设有控制装置,热敏灸柱插入对应的热敏灸柱槽内。本发明的优点,整个过程都通过本装置固定大鼠,大大提高了实验效率；头筒内有硅胶垫层和黑棉布,适应了大鼠喜暗和钻洞的习性,起到延长大鼠安静时间的作用；通过伸缩杆伸缩保持热敏灸柱距主筒体的位置恒定,保证了热敏灸的效果；可监测实验过程中大鼠的体温；主筒体采用网格材质,保证了大鼠所处空间的透气性,并且具有无毒、无味、柔韧、绝缘的特点,容易定制且可在无特定病原体环境中使用。(The invention discloses a psoriasis experimental research device and a using method thereof, wherein the psoriasis experimental research device comprises a main cylinder body and a control box, the main cylinder body is connected to the upper end of the control box through a telescopic rod, the front side of the main cylinder body is connected with a head cylinder, the rear end of the main cylinder body is connected with a tail fixing rod, a control device is arranged in the control box, and thermosensitive moxibustion columns are inserted into corresponding thermosensitive moxibustion column grooves. The invention has the advantages that the rat is fixed by the device in the whole process, so that the experimental efficiency is greatly improved; the head cylinder is internally provided with a silica gel cushion layer and black cotton cloth, so that the rat-shaped head cylinder adapts to the habit of rat's darkness and hole drilling and plays a role in prolonging the resting time of the rat; the telescopic rod is telescopic to keep the position of the thermosensitive moxibustion column away from the main cylinder body constant, so that the effect of thermosensitive moxibustion is ensured; the body temperature of the rat in the experimental process can be monitored; the main cylinder body is made of grid materials, so that the air permeability of the space where the rat is located is guaranteed, the main cylinder body has the characteristics of no toxicity, no odor, flexibility and insulation, and the main cylinder body is easy to customize and can be used in the environment without specific pathogens.)

1. An experimental research device for psoriasis, which is characterized in that: it includes main barrel body (1) and control box (2), main barrel body (1) is connected through telescopic link (3) the upper end of control box (2), the upper end of main barrel body (1) is equipped with and can opens formula apron (4), the front side connector barrel (5) of main barrel body (1), tail dead lever (6) is connected to the rear end of main barrel body (1), the inside of control box (2) is equipped with controlling means (7), open the upper end of control box (2) has a plurality of temperature sensing moxibustion post grooves (8), and temperature sensing moxibustion post (9) insert and correspond in temperature sensing moxibustion post groove (8), temperature sensing moxibustion post (9) are located the below of main barrel body (1).

2. An experimental research device for psoriasis according to claim 1, wherein: the telescopic rod (3) is provided with two, every the lower extreme of telescopic rod (3) all connects corresponding flexible controlling means (10), flexible controlling means (10) set up the inside of control box (2), flexible controlling means (10) electricity is connected to controlling means (7).

3. An experimental research device for psoriasis according to claim 1, wherein: the front view surface of the control box (2) is provided with an interactive display screen (11), and the interactive display screen (11) is electrically connected to the control device (7).

4. An experimental research device for psoriasis according to claim 1, wherein: the control box (2) is provided with a excrement barrel (12), and the excrement barrel (12) is positioned below the rear side of the main barrel body (1).

5. An experimental research device for psoriasis according to claim 1, wherein: the inboard of a head section of thick bamboo (5) is equipped with one deck silica gel bed course (13), the inboard of silica gel bed course (13) is equipped with one deck black cotton cloth (20), be equipped with temperature sensor (19) on tail dead lever (6), temperature sensor (19) electricity is connected to controlling means (7), the diameter of main barrel body (1) is 7-9cm, and length is 15-17cm, the apron size is 5cm x 8cm, main barrel body (1) is latticed structure, and the four limbs of rat stretch out the net to it is fixed with the U type clamp.

6. An experimental research device for psoriasis according to claim 1, wherein: eight thermosensitive moxibustion column grooves (8) are arranged and are arranged according to the acupuncture point diagram.

7. An experimental research device for psoriasis according to claim 6, wherein: the two thermosensitive moxibustion column grooves (8) positioned on the front side are two hand shaoyang trifoliate channels externally-closed acupoint grooves (14), the two thermosensitive moxibustion column grooves (8) positioned on the rear side are two Zusanli acupoint grooves (15), the two thermosensitive moxibustion column grooves (8) positioned in the middle are Tianshu acupoint grooves (16), the rest two thermosensitive moxibustion column grooves (8) are a Zhongwan acupoint groove (17) and a Guanyuan acupoint groove (18), the Zhongwan acupoint groove (17) is positioned between the hand shaoyang trifoliate channels externally-closed acupoint groove (14) and the Tianshu acupoint groove (16), and the Guanyuan acupoint groove (18) is positioned between the foot shaoyang trifoliate acupoint groove (15) and the Tianshu acupoint groove (16).

8. A method of use for a psoriasis experimental study device, the method comprising: which comprises the following steps:

step one, a rat to be tested is placed in a main cylinder body (1), the head of the rat is positioned in a head cylinder (5), and the tail of the rat is fixed in a tail fixing rod (6);

step two, opening the cover plate (4) to mold the back of the rat, wherein the molding is performed after shaving in an area of 2cm multiplied by 4cm on the back of the rat, observing a skin preparation area and the whole condition of the rat every day, recording data, and judging whether the molding is successful according to PSAI (particle swarm optimization) scores;

setting the automatic rising speed of the telescopic rod (3) through the interactive display screen (11);

fourthly, inserting the heat-sensitive moxibustion column (9) into the heat-sensitive moxibustion column groove (8) corresponding to the acupuncture point;

step five, igniting the heat-sensitive moxibustion column for treatment (9);

and step six, immediately detecting the terahertz wave acupuncture points after the stage treatment is finished to obtain experimental data.

9. A psoriasis experimental study method is characterized in that: during the experiment, the rats are randomly divided into three groups, namely a physiological saline group, a model group and a thermosensitive moxibustion group, the three groups of physiological saline groups directly carry out terahertz wave acupoint detection to obtain experiment data, the model group firstly carries out back modeling successfully and then carries out terahertz wave acupoint detection to obtain experiment data, the thermosensitive moxibustion group firstly carries out back modeling and then carries out thermosensitive moxibustion treatment, and terahertz wave acupoint detection is immediately carried out after stage treatment is finished to obtain experiment data.

10. A psoriasis experimental study method according to claim 9 wherein: the three groups of normal saline groups are healthy rats and coated with normal saline on the back every day after skin preparation, the model group is rats which are not treated by diseases, the thermosensitive moxibustion groups are divided into groups, a first group is that two hand shaoyang trifocal meridian externally-closed acupoint grooves (14) are inserted into the thermosensitive moxibustion columns (9), a second group is that two Tianshu acupoint grooves (16) and epigastric acupoint grooves (17) and Guanyuan acupoint grooves (18) are inserted into the thermosensitive moxibustion columns (9), and a third group is that two Zusanli acupoint grooves (15) are inserted into the thermosensitive moxibustion columns (9).

Technical Field

The invention relates to a psoriasis experimental research device and a using method thereof, belonging to the technical field of psoriasis experimental research.

Background

Psoriasis is commonly called as psoriasis, is a chronic inflammatory dermatosis, has a long course of disease and a tendency of easy relapse, some cases are not cured all the time, the clinical manifestations mainly comprise erythema and scale, the disease can be developed on the whole body, the scalp and the limbs are more common, and the disease is aggravated in winter mostly. At present, no specific treatment is available, but the treatment is not an incurable disease, and the proper symptomatic treatment can control symptoms, and is mostly controlled by medicines at present. The traditional acupuncture and moxibustion and other methods in China also have certain curative effect on psoriasis, wherein the thermosensitive moxibustion is one of the methods, the thermosensitive moxibustion adopts moxa heat generated by ignited moxa materials to suspend moxibustion heat-sensitive acupuncture points, and heat-sensitive moxibustion feelings such as diathermy, heat expansion, heat transfer, local non (micro) heat far-away heat, surface non (micro) heat deep heat, non-heat sensation and the like and channel gas conduction are excited, and individualized saturated desensitization moxibustion quantity is applied, so that a new moxibustion curative effect is improved. The psoriasis is researched by a rat, but no fixing device specially used for the experiment exists at present, so that the research efficiency is severely limited.

Disclosure of Invention

The invention aims to solve the technical problem of providing a psoriasis experimental research device and a using method thereof.

The invention is realized by the following scheme: the utility model provides a be used for psoriasis experimental study device and application method thereof, it includes main barrel and control box, main barrel passes through the telescopic link and connects the upper end of control box, the upper end of main barrel is equipped with the formula of can opening apron, the front side connector section of thick bamboo of main barrel, the tail dead lever is connected to the rear end of main barrel, the inside of control box is equipped with controlling means, open the upper end of control box has a plurality of temperature sensing moxibustion post grooves, and the temperature sensing moxibustion post inserts corresponding temperature sensing moxibustion post inslot, the temperature sensing moxibustion post is located the below of main barrel.

The telescopic link is equipped with two, every the telescopic link's lower extreme all connects corresponding flexible controlling means, flexible controlling means sets up the inside of control box, flexible controlling means electric connection to controlling means.

The front view surface of the control box is provided with an interactive display screen, and the interactive display screen is electrically connected to the control device.

The control box is provided with a excrement barrel which is positioned below the rear side of the main barrel body.

The inboard of a head section of thick bamboo is equipped with one deck silica gel bed course, the inboard of silica gel bed course is equipped with one deck black cotton, be equipped with temperature sensor on the tail dead lever, temperature sensor electricity is connected to controlling means, the diameter of main barrel body is 7-9cm, and length is 15-17cm, the apron size is 5cm x 8cm, main barrel body is latticed structure, and the four limbs of rat stretch out the net to it is fixed with U type clamp.

Eight thermosensitive moxibustion column grooves are formed and are arranged according to the acupuncture point diagram.

The two thermosensitive moxibustion column grooves positioned on the front side are two hand shaoyang trifocal channels Waoguan acupoint grooves, the two thermosensitive moxibustion column grooves positioned on the rear side are two Zusanli acupoint grooves, the two thermosensitive moxibustion column grooves positioned in the middle are Tianshu acupoint grooves, the rest two thermosensitive moxibustion column grooves are respectively Zhongwan acupoint grooves and Guanyuan acupoint grooves, the Zhongwan acupoint grooves are positioned between the hand shaoyang trifocal channels Waoguan acupoint grooves and the Tianshu acupoint grooves, and the Guanyuan acupoint grooves are positioned between the Zusanli acupoint grooves and the Tianshu acupoint grooves.

A method of use for a psoriasis experimental study device comprising the steps of:

step one, a rat to be tested is placed in a main cylinder, the head of the rat is positioned in a head cylinder, and the tail of the rat is fixed in a tail fixing rod;

opening a cover plate, carrying out back molding on the rat, wherein the molding is carried out after shaving in an area of 2cm multiplied by 4cm on the back of the rat, observing a skin preparation area and the whole condition of the rat every day, recording data, and judging whether the molding is successful according to PSAI (particle swarm optimization) scores;

setting the automatic rising speed of the telescopic rod through the interactive display screen;

inserting the thermosensitive moxibustion column into the thermosensitive moxibustion column groove corresponding to the acupuncture point;

step five, igniting the heat-sensitive moxibustion column for treatment;

and step six, immediately detecting the terahertz wave acupuncture points after the stage treatment is finished to obtain experimental data.

During the psoriasis experiment, rats are randomly divided into three groups, namely a normal saline group, a model group and a thermosensitive moxibustion group, the three groups of normal saline groups directly carry out terahertz wave acupoint detection to obtain experiment data, the model group firstly carries out back modeling successfully and then carries out terahertz wave acupoint detection to obtain experiment data, the thermosensitive moxibustion group firstly carries out back modeling and then carries out thermosensitive moxibustion treatment, and the terahertz wave acupoint detection is immediately carried out after stage treatment is finished to obtain the experiment data.

The three groups of normal saline groups are healthy rats and coated with normal saline on the back every day after skin preparation, the model group is rats which are not treated by diseases, the thermosensitive moxibustion groups are divided into groups, the first group is that two hand shaoyang triple energizer meridian external-Guanyu acupoint slots are inserted into the thermosensitive moxibustion columns, the second group is that two Tianshu acupoint slots, Zhongwan acupoint slots and Guanyuan acupoint slots are inserted into the thermosensitive moxibustion columns, and the third group is that two Zusanli acupoint slots are inserted into the thermosensitive moxibustion columns.

The invention has the beneficial effects that:

1. according to the invention, the rat is fixed, then the operations such as modeling, heat-sensitive moxibustion, terahertz wave acupoint detection and the like are carried out to obtain experimental data, and the rat is fixed by the device in the whole process, so that the experimental efficiency is greatly improved;

2. the psoriasis experimental research device is provided with the head cylinder, the silica gel cushion layer and the black cotton cloth are arranged in the head cylinder, the habit of rat's darkness and hole drilling is adapted, and the effect of prolonging the resting time of the rat is achieved;

3. the invention keeps the constant position of the thermosensitive moxibustion column from the main cylinder body through the expansion and contraction of the telescopic rod, thereby ensuring the effect of the thermosensitive moxibustion;

4. the device for psoriasis experimental study is provided with the tail fixing rod, the tail fixing rod is provided with the temperature sensor, and the tail temperature of a rat in the experimental process can be monitored;

5. the main cylinder body of the psoriasis experimental research device is made of the grid material, so that the air permeability of the space where the rat is located is ensured, the main cylinder body has the characteristics of no toxicity, no smell, flexibility and insulation, and the influence of other environments on the experimental result is reduced;

6. the invention relates to a psoriasis experimental research device which is provided with an excrement barrel and is used for collecting excrement of a rat in the experimental process.

Drawings

Fig. 1 is a schematic front view of the experimental research device for psoriasis according to the present invention.

Fig. 2 is a schematic structural diagram of a head cylinder front view section of the experimental research device for psoriasis.

Fig. 3 is a schematic top view of a control box of the experimental research device for psoriasis.

Fig. 4 is a top view of a acupuncture point diagram of a control box for a psoriasis experimental study device of the present invention.

In the figure: the multifunctional moxibustion device comprises a main barrel body 1, a control box 2, a telescopic rod 3, an openable cover plate 4, a head barrel 5, a tail fixing rod 6, a control device 7, a thermosensitive moxibustion column groove 8, a thermosensitive moxibustion column 9, a telescopic control device 10, an interactive display screen 11, an excrement barrel 12, a silica gel cushion layer 13, a hand shaoyang sanjiao channel Waoguan acupoint groove 14, a Zusanli acupoint groove 15, a Tianshu acupoint groove 16, a Zhongwan acupoint groove 17, a Guanyuan acupoint groove 18, a temperature sensor 19 and black cotton cloth 20.

Detailed Description

The invention is further described below with reference to fig. 1-4, without limiting the scope of the invention.

In which like parts are designated by like reference numerals. It is noted that the terms "front", "back", "left", "right", "upper" and "lower" used in the following description refer to directions in the drawings, the terms "inner" and "outer" refer to directions toward and away from, respectively, the geometric center of a particular component, and the drawings are in greatly simplified form and employ non-precise ratios, merely for the purpose of facilitating and distinctly aiding in the description of the embodiments of the present invention.

In the following description, for purposes of clarity, not all features of an actual implementation are described, well-known functions or constructions are not described in detail since they would obscure the invention with unnecessary detail, it being understood that in the development of any actual embodiment, numerous implementation details must be set forth in order to achieve the developer's specific goals, such as compliance with system-related and business-related constraints, changing from one implementation to another, and it being recognized that such development effort might be complex and time consuming, but would nevertheless be a routine undertaking for those of ordinary skill in the art.

The utility model provides a be used for psoriasis experimental study device and application method thereof, it includes main barrel 1 and control box 2, main barrel 1 passes through telescopic link 3 to be connected in the upper end of control box 2, the upper end of main barrel 1 is equipped with openable apron 4, the front side connector barrel 5 of main barrel 1, tail dead lever 6 is connected to the rear end of main barrel 1, the inside of control box 2 is equipped with controlling means 7, the upper end of control box 2 is opened has a plurality of temperature sensing moxibustion post grooves 8, temperature sensing moxibustion post 9 inserts in the temperature sensing moxibustion post groove 8 that corresponds, temperature sensing moxibustion post 9 is located the below of main barrel 1.

The telescopic links 3 are provided with two telescopic rods, the lower end of each telescopic link 3 is connected with a corresponding telescopic control device 10, the telescopic control devices 10 are arranged inside the control box 2, and the telescopic control devices 10 are electrically connected to the control device 7.

The front view surface of the control box 2 is provided with an interactive display screen 11, and the interactive display screen 11 is electrically connected to the control device 7.

The control box 2 is provided with a waste barrel 12, and the waste barrel 12 is positioned below the rear side of the main barrel body 1.

The inboard of head section of thick bamboo 5 is equipped with a layer silica gel bed course 13, and the inboard of silica gel bed course 13 is equipped with a layer black cotton 20.

Eight thermosensitive moxibustion column grooves 8 are arranged and arranged according to the acupoint map.

Two heat-sensitive moxibustion column grooves 8 positioned on the front side are two hand shaoyang trifoliate meridian external acupuncture point grooves 14, two heat-sensitive moxibustion column grooves 8 positioned on the rear side are two Zusanli acupuncture point grooves 15, two heat-sensitive moxibustion column grooves 8 positioned in the middle are Tianshu acupuncture point grooves 16, the remaining two heat-sensitive moxibustion column grooves 8 are a Zhongwan acupuncture point groove 17 and a Guanyuan acupuncture point groove 18 respectively, the Zhongwan acupuncture point groove 17 is positioned between the hand shaoyang trifoliate meridian external acupuncture point groove 14 and the Tianshu acupuncture point groove 16, and the Guanyuan acupuncture point groove 18 is positioned between the Zusanli acupuncture point groove 15 and the Tianshu acupuncture point groove 16.

The tail fixing rod 6 is provided with a temperature sensor 19, the temperature sensor 19 is electrically connected to the control device 7, the diameter of the main cylinder body 1 is 7-9cm, the length of the main cylinder body is 15-17cm, the size of the cover plate is 5cm multiplied by 8cm, the main cylinder body 1 is of a grid structure, and four feet of a rat extend out of the grid and are fixed by U-shaped clamps.

A method of use for a psoriasis experimental study device comprising the steps of:

step one, a rat to be tested is placed in a main cylinder body 1, the head of the rat is positioned in a head cylinder 5, and the tail of the rat is fixed in a tail fixing rod 6;

step two, opening the cover plate 4 (paying attention to the fact that the broken ends of the silk screen are reversely folded and internally buckled to prevent the rats from being scratched in the experiment), carrying out back molding on the rats, wherein the molding is carried out after shaving in an area of 2cm multiplied by 4cm on the backs of the rats, observing the skin preparation area and the whole conditions of the rats every day, recording data, and judging whether the molding is successful according to PSAI (particle swarm optimization) scores;

thirdly, setting the automatic rising speed of the telescopic rod 3 through the interactive display screen 11;

step four, inserting the heat-sensitive moxibustion column 9 into the heat-sensitive moxibustion column groove 8 of the corresponding acupuncture point;

step five, igniting the heat-sensitive moxibustion column for treatment 9;

and step six, immediately detecting the terahertz wave acupuncture points after the stage treatment is finished to obtain experimental data.

A psoriasis experiment research method comprises the steps that rats are randomly divided into three groups of normal saline groups, a model group and a heat-sensitive moxibustion group during an experiment, the three groups of normal saline groups are directly subjected to terahertz wave acupoint detection to obtain experiment data, the rats are randomly divided into three groups of normal saline groups, the model group and the heat-sensitive moxibustion group during a back modeling experiment, the three groups of normal saline groups are directly subjected to terahertz wave acupoint detection to obtain experiment data, the model group is successfully subjected to back modeling before to perform terahertz wave acupoint detection to obtain experiment data, the heat-sensitive moxibustion group is subjected to back modeling firstly and then heat-sensitive moxibustion treatment, and the terahertz wave acupoint detection is immediately performed after stage treatment is finished to obtain the experiment data. And then terahertz wave acupoint detection is carried out to obtain experimental data, a thermosensitive moxibustion group is firstly used for back molding and then thermosensitive moxibustion treatment is carried out, the terahertz wave acupoint detection is carried out in the treatment process to obtain the experimental data, three groups of physiological saline are healthy rats, physiological saline is coated on the back every day after skin preparation, a model group is rats which are not treated, the thermosensitive moxibustion group is divided into groups, a first group is that a thermosensitive moxibustion column 9 is inserted into two hand shaoyang trifocal channel Waoguan acupoint grooves 14, a second group is that a thermosensitive moxibustion column 9 is inserted into two Tianshu acupoint grooves 16 and a Zhongwan acupoint groove 17 and a Guanyuan acupoint groove 18, and a third group is that a thermosensitive moxibustion column 9 is inserted into two Zusanli acupoint grooves 15.

The research of acupoints of experimental animals is used as a main acupoint determination reference, and Zusanli is positioned at the rear outer side of the knee joint and about 5mm below the small head of the fibula; the channel of the triple energizer of hand shaoyang lies on the wrist joint of the rat by 3mm, between the ulna and radius, and on each of the left and right acupoints; the guanyuan is located about 25mm below the navel of the rat; the epigastrium is located about 20mm above the umbilicus; the Tianshu is located 5mm lateral to the umbilicus of the rat.

Although the invention has been described and illustrated in some detail, it should be understood that various modifications may be made to the described embodiments or equivalents may be substituted, as will be apparent to those skilled in the art, without departing from the spirit of the invention.