阅读说明：本技术 一种治疗男性不育的益肾生精丸及其制备方法 (Kidney-tonifying and sperm-producing pill for treating male infertility and preparation method thereof ) 是由 廖勇 于 2021-08-30 设计创作，主要内容包括：本发明属于中药技术领域,涉及一种治疗男性不育的益肾生精丸及其制备方法,所述益肾生精丸包括如下重量的原料药：仙灵脾15-25g、枸杞子15-25g、覆盆子10-20g、韭菜子5-15g、当归5-15g、山茱萸10-20g、鹿茸4-10g、五味子3-10g、补骨脂5-15g、桑葚子10-20g、女贞子10-20g、黄芪15-30g和怀山药10-20g。本发明益肾生精丸滋肾、化源、生精、助育,适合肾阴虚、肾阳虚及脾虚患者,治疗效果显著,原料种类少,应用范围广泛。(The invention belongs to the technical field of traditional Chinese medicines, and relates to a kidney-tonifying and sperm-producing pill for treating male infertility and a preparation method thereof, wherein the kidney-tonifying and sperm-producing pill comprises the following raw material medicines by weight: 15-25g of herba epimedii, 15-25g of wolfberry fruit, 10-20g of raspberry, 5-15g of semen allii tuberosi, 5-15g of angelica sinensis, 10-20g of dogwood, 4-10g of cornu cervi pantotrichum, 3-10g of schisandra chinensis, 5-15g of fructus psoraleae, 10-20g of mulberry, 10-20g of glossy privet fruit, 15-30g of astragalus mongholicus and 10-20g of dioscorea opposita. The kidney-tonifying and sperm-producing pill provided by the invention can nourish kidney, transform source, produce sperm and assist breeding, is suitable for patients with deficiency of kidney yin, deficiency of kidney yang and deficiency of spleen, and has the advantages of obvious treatment effect, few raw material types and wide application range.)

1. The kidney-tonifying and sperm-producing pill for treating male infertility is characterized by comprising the following raw material medicines by weight: 15-25g of herba epimedii, 15-25g of wolfberry fruit, 10-20g of raspberry, 5-15g of semen allii tuberosi, 5-15g of angelica sinensis, 10-20g of dogwood, 4-10g of cornu cervi pantotrichum, 3-10g of schisandra chinensis, 5-15g of fructus psoraleae, 10-20g of mulberry, 10-20g of glossy privet fruit, 15-30g of astragalus mongholicus and 10-20g of dioscorea opposita.

2. The kidney-tonifying sperm-producing pill for treating male infertility according to claim 1, which is characterized by comprising the following raw material medicines by weight: 20g of herba epimedii, 20g of wolfberry fruit, 15g of raspberry, 10g of semen allii tuberosi, 10g of angelica, 15g of dogwood, 6g of cornu cervi pantotrichum, 6g of schisandra chinensis, 10g of fructus psoraleae, 15g of mulberry, 12g of glossy privet fruit, 20g of astragalus mongholicus and 15g of dioscorea opposita.

3. The kidney-tonifying and sperm-producing pill for the treatment of male infertility according to claim 1, further comprising 1 to 5g of cinnamon and 8 to 15g of cistanche deserticola.

4. The kidney-tonifying spermatogenic pill for treating male infertility according to claim 3, which is characterized by comprising the following raw material medicines by weight: 20g of herba epimedii, 20g of wolfberry fruit, 15g of raspberry, 10g of semen allii tuberosi, 10g of angelica, 15g of dogwood, 6g of cornu cervi pantotrichum, 6g of schisandra chinensis, 10g of fructus psoraleae, 15g of mulberry, 12g of glossy privet fruit, 20g of astragalus membranaceus, 15g of dioscorea opposita thumb, 3g of cinnamon and 10g of cistanche.

5. A method for preparing the kidney-tonifying and sperm-producing pill for treating male infertility according to any one of claims 1 to 4, comprising the steps of:

(1) cleaning the raw materials, air drying, spreading, and continuously sterilizing with ultraviolet rays for 50-100 min;

(2) uniformly stirring the raw material medicines treated in the step (1), crushing to 150-200 meshes by using a crusher, spreading again, and sterilizing for 50-100min by using ultraviolet rays;

(3) and (3) decocting the polished round-grained rice to be pasty as a matrix, uniformly stirring the ground substance and the medicinal powder obtained in the step (2), making pills with the diameter of 4-6mm on a pharmaceutical machine, and drying in the sun to obtain the traditional Chinese medicine.

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and relates to a kidney-tonifying and sperm-producing pill for treating male infertility and a preparation method thereof.

Background

According to the theory of traditional Chinese medicine, male infertility clinically has primary and secondary symptoms, the etiology is weak in innate endowment, and kidney is not storing essence to cause kidney qi deficiency; or factors of overeating and fatness, obesity, dampness generation and phlegm accumulation, and qi movement disorder; or kidney essence deficiency and blood stasis, blood stasis obstructing essence passage, or heart-over-work, excessive heart-fire, kidney-water failing to rise and heart-kidney failing to intersect, kidney essence deficiency, and decline of vital gate-fire; or due to anxiety, emotional disorder, stagnation of liver-qi, disorder of flow-regulating, disharmony of blood and qi, deficiency of pectoral qi, deficiency of kidney and liver-qi stagnation; pregnancy is a complex physiological process, and many pathogenic factors are caused, for example, in the doctor's work from syndrome treating and caring, men mostly concentrate on essence and tonify kidney. The principle of spleen governing transportation and transformation of food essence and kidney storing essence is considered in traditional Chinese medicine. Essence is the original material of life, has the functions of growing and reproducing offspring and the like, and can cause sterility due to kidney essence deficiency.

The Chinese patent application with publication number CN110433250A discloses a traditional Chinese medicine composition for invigorating kidney and strengthening yang and a preparation method thereof, and aims to solve the problem of providing a traditional Chinese medicine composition for improving immunity of organisms, invigorating kidney, strengthening spleen and replenishing qi, and having good effects of invigorating kidney and strengthening yang and a preparation method thereof, wherein the adopted technical scheme is as follows: comprises the following medicinal materials: 2-15 parts of ginseng, 2-15 parts of maca, 5-20 parts of rhizoma polygonati, 5-20 parts of medlar, 5-20 parts of clove, 5-20 parts of raspberry, 5-20 parts of yam, 5-20 parts of gordon euryale seed, 2-20 parts of codonopsis pilosula, 5-20 parts of astragalus, 5-20 parts of longan, 5-20 parts of lily and 5-20 parts of angelica; the invention can enhance male sexual excitation, prolong sexual love time, relieve kidney deficiency, strengthen renal function, activate male physiological metabolism, enhance body constitution, and maintain energetic. However, the patent belongs to yang-strengthening drugs, and male infertility patients are usually suffered from congenital deficiency, long-term fatigue and weak constitution, and the weak body fails to surpass the efficacy of drugs, so that yin and yang of kidney are not nourished.

The Chinese patent application with the publication number of CN109125642A discloses a traditional Chinese medicine composition for treating male infertility, which is prepared from the following medicines in parts by weight: 8-12 parts of male silkworm moth, 8-12 parts of centipede, 7-9 parts of angelica dahurica, 8-12 parts of angelica, 8-12 parts of fructus broussonetiae, 8-12 parts of semen phragmitis, 8-12 parts of fructus leonuri, 8-12 parts of Chinese chive seed, 8-12 parts of antler slice, 13-17 parts of herba epimedii, 13-17 parts of semen plantaginis, 8-12 parts of cynomorium songaricum, 13-17 parts of medlar, 13-17 parts of dipsacus root, 13-17 parts of mistletoe, 4-6 parts of schisandra chinensis, 28-32 parts of dandelion, 28-32 parts of roasted malt, 13-17 parts of roasted rice sprout, 8-12 parts of raspberry, 16-20 parts of semen cuscutae, 5-7 parts of liquorice and 13-17 parts of actinolite. The traditional Chinese medicine composition disclosed by the invention is used for both cold and warm and catharsis, has the effects of warming essence and tonifying yang, producing essence and tonifying kidney, and clearing heat and promoting diuresis, and has a higher curative effect on treating male infertility. However, the patent applies various medicines with cold and cool properties, and aims to neutralize the yang-heat force of the used yang-tonifying and interior-warming medicines, but male infertility patients are often accompanied with symptoms of spleen yang deficiency, and the cold and cool medicines further damage spleen qi, so that the transportation and transformation functions of the spleen are disordered and water-dampness is stagnated, food essence cannot supplement the innate qi of the kidney, and the spleen-kidney yang deficiency and kidney essence deficiency are caused.

Disclosure of Invention

In order to overcome the defects, the invention aims to provide the kidney-tonifying and sperm-producing pill for treating male infertility and the preparation method thereof, and the pill has the advantages of obvious treatment effect, few raw material types and wide application range.

In order to achieve the purpose, the invention adopts the following technical scheme:

a kidney-tonifying and sperm-producing pill for treating male infertility comprises the following raw material medicines by weight: 15-25g of herba epimedii, 15-25g of wolfberry fruit, 10-20g of raspberry, 5-15g of semen allii tuberosi, 5-15g of angelica sinensis, 10-20g of dogwood, 4-10g of cornu cervi pantotrichum, 3-10g of schisandra chinensis, 5-15g of fructus psoraleae, 10-20g of mulberry, 10-20g of glossy privet fruit, 15-30g of astragalus mongholicus and 10-20g of dioscorea opposita.

A kidney-tonifying and sperm-producing pill for treating male infertility comprises the following raw material medicines by weight: 20g of herba epimedii, 20g of wolfberry fruit, 15g of raspberry, 10g of semen allii tuberosi, 10g of angelica, 15g of dogwood, 6g of cornu cervi pantotrichum, 6g of schisandra chinensis, 10g of fructus psoraleae, 15g of mulberry, 12g of glossy privet fruit, 20g of astragalus mongholicus and 15g of dioscorea opposita.

Preferably, the medicine also comprises 1-5g of cinnamon and 8-15g of cistanche.

Preferably, the kidney-tonifying and sperm-producing pill for treating male infertility comprises the following raw material medicines by weight: 20g of herba epimedii, 20g of wolfberry fruit, 15g of raspberry, 10g of semen allii tuberosi, 10g of angelica, 15g of dogwood, 6g of cornu cervi pantotrichum, 6g of schisandra chinensis, 10g of fructus psoraleae, 15g of mulberry, 12g of glossy privet fruit, 20g of astragalus membranaceus, 15g of dioscorea opposita thumb, 3g of cinnamon and 10g of cistanche.

A preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility comprises the following steps:

(1) cleaning the above materials, air drying, spreading, and continuously sterilizing with ultraviolet rays for 50-100 min;

(2) uniformly stirring the raw material medicines treated in the step (1), crushing to 150-200 meshes by using a crusher, spreading again, and sterilizing for 50-100min by using ultraviolet rays;

(3) and (3) decocting the polished round-grained rice to be pasty as a matrix, uniformly stirring the ground substance and the medicinal powder obtained in the step (2), making pills with the diameter of 4-6mm on a pharmaceutical machine, and drying in the sun to obtain the traditional Chinese medicine.

The sperm-eliminating pill matched with the kidney-tonifying sperm-generating pill for treating male infertility comprises the following raw materials by weight: 15-25g of herba epimedii, 15-25g of wolfberry fruit, 10-20g of raspberry, 5-15g of semen allii tuberosi, 5-15g of angelica sinensis, 10-20g of dogwood, 3-10g of schisandra chinensis, 10-20g of mulberry, 10-20g of glossy privet fruit, 10-20g of astragalus membranaceus, 10-20g of dioscorea opposita thumb, 10-20g of rhizoma anemarrhenae, 10-20g of phellodendron amurense and 10-20g of rhizoma smilacis glabrae.

Preferably, the refined pills comprise the following raw materials in parts by weight: 20g of herba epimedii, 20g of wolfberry fruit, 15g of raspberry, 10g of semen allii tuberosi, 10g of angelica, 15g of dogwood, 6g of schisandra chinensis, 15g of mulberry fruit, 12g of glossy privet fruit, 15g of astragalus membranaceus, 15g of dioscorea opposita thumb, 15g of rhizoma anemarrhenae, 15g of phellodendron amurense and 15g of rhizoma smilacis glabrae.

The taking method comprises the following steps: each pill is 0.15g, 480 pills are packed into a bottle, and the pill is taken 3 times a day, 20-30 pills each time, about half an hour before meals, the kidney-tonifying and sperm-producing pills and the sperm-transforming pills can be taken separately or alternately in one round of one day, the two medicines are not taken on the same day, and the specific taking method can be adjusted properly according to the condition of patients.

The invention has the following positive beneficial effects:

the pharmacological action of each raw material medicine of the invention is as follows:

herba Epimedii: it is also called epimedium herb, pungent and sweet, warm, enters liver and kidney meridians, tonifies kidney yang, strengthens muscles and bones, dispels wind-damp, and is used for impotence and spermatorrhea, flaccidity of muscles and bones, rheumatic arthralgia, numbness and contracture.

Wolfberry fruit: sweet and neutral, enter liver and kidney meridians, nourish liver and kidney, supplement essence and improve eyesight, and are indicated for consumptive disease and essence deficiency. For example, soreness and pain of knee, vertigo, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion and blurred vision.

Raspberry: sweet and sour, warm and warm, enter kidney and bladder channels, tonify kidney, secure essence and reduce urination, and are used for treating kidney deficiency and enuresis, frequent urination, impotence and premature ejaculation, spermatorrhea and spermatorrhea.

Leek seeds: pungent and sweet with warm property, entering liver and kidney meridians, warming and invigorating liver and kidney, tonifying yang and arresting spontaneous emission, and can be used for treating sexual impotence, spermatorrhea, soreness of waist and knees, enuresis, frequent micturition, leukorrhagia with turbid urine.

Chinese angelica: sweet, pungent and warm, entering liver, heart and spleen channels, tonifying blood and activating blood, regulating menstruation and relieving pain, and loosening bowel to relieve constipation, and can be used for treating blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, deficiency cold and abdominal pain, constipation due to intestinal dryness, rheumatalgia, traumatic injury, carbuncle, cellulitis, and pyocutaneous disease. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.

Dogwood fruit: sour, astringent and slightly warm, enter liver and kidney meridians, tonify liver and kidney, astringe essence and relieve depletion, and are used for vertigo, tinnitus, soreness and pain of waist and knees, and frequent yang and spermatorrhea. Enuresis, frequent urination, metrorrhagia, leukorrhagia, profuse sweating, exhaustion of the body, internal heat, diabetes.

Pilose antler: sweet, salty and warm, entering kidney and liver meridians, invigorating kidney yang, replenishing essence and blood, strengthening tendons and bones, regulating Chong and ren meridians, and relieving sore toxicity, and can be used for treating impotence, spermatorrhea, infertility due to cold womb, emaciation, listlessness, aversion to cold, dizziness, tinnitus, deafness, cold pain in waist and back, flaccidity of bones and muscles, metrorrhagia, leukorrhagia, and unhealing deep-rooted carbuncle of yin.

Schisandra chinensis: sour, sweet and warm, enter lung, heart and kidney meridians, astringe and arrest discharge, tonify qi and promote the production of body fluid, tonify kidney and calm heart, and are used for treating chronic cough, dyspnea due to deficiency, nocturnal emission, spermatorrhea, enuresis, frequent micturition, chronic diarrhea, spontaneous perspiration, night sweat, body fluid deficiency, thirst, shortness of breath and pulse, internal heat, diabetes, palpitation and insomnia.

Psoralea fruit: pungent, bitter and warm, enter kidney and spleen channels, warm kidney and strengthen yang, receive qi and stop diarrhea, and are used for impotence and spermatorrhea, enuresis and frequent micturition, cold pain of waist and knees, asthma due to kidney deficiency and morning diarrhea; it is used externally to treat vitiligo and alopecia areata.

Mulberry fruit: sweet, sour and cold, entering heart, liver and kidney meridians, nourishing yin and blood, promoting the production of body fluid and moistening dryness. Can be used for treating liver and kidney yin deficiency, giddiness, tinnitus, palpitation, insomnia, premature gray hair, thirst due to body fluid consumption, internal heat, diabetes, intestinal burst, and constipation.

Glossy privet fruit: sweet, bitter and cool, enter liver and kidney meridians, nourish liver and kidney, improve eyesight and blacken hair, and are used for treating liver and kidney yin deficiency, dizziness and tinnitus, soreness and weakness of waist and knees, early white beard and hair, dim eyesight, internal heat and thirst, bone steaming and tidal fever.

Astragalus root: sweet and warm in nature, it enters spleen and lung meridians. Invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, expelling toxin, expelling pus, healing sore, and promoting granulation. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, edema, oliguria, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, lung qi deficiency, cough with dyspnea, exterior deficiency, spontaneous perspiration, internal heat, diabetes, blood deficiency, sallow complexion, deficiency of both qi and blood, qi deficiency, blood stagnation, hemiplegia, arthralgia, numbness, deficiency of both qi and blood, carbuncle, ulcer, and long-term ulcer.

Chinese yam rhizome: sweet and neutral, enter spleen, lung and kidney meridians, tonify spleen and stomach, promote the production of body fluid and benefit lung, tonify kidney and astringe essence, and are used for treating spleen deficiency and poor appetite, chronic diarrhea, leukorrhagia, lung deficiency and cough, kidney deficiency and spermatorrhea, leukorrhagia, frequent micturition, deficiency heat and thirst quenching.

Cinnamon: pungent and sweet with strong heat, entering kidney, spleen, heart and liver meridians, tonifying fire and yang, guiding fire to origin, dispelling cold and relieving pain, promoting blood circulation and dredging channels, and can be used for treating sexual impotence, cold womb, cold pain of waist and knee, asthma due to kidney deficiency, yang deficiency vertigo, conjunctival congestion pharyngalgia, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, hernia due to cold, galloping, amenorrhea and dysmenorrhea.

Cistanche deserticola: sweet, salty and warm, entering kidney and large intestine meridians, tonifying kidney yang, benefiting essence and blood, moistening intestine and relaxing bowels, and can be used for treating impotence, infertility, soreness and weakness of waist and knees, weakness of tendons and bones, and constipation due to intestinal dryness.

In the prescription, the epimedium herb tonifies kidney yang and benefits essence and blood; fructus Lycii has effects in nourishing essence and blood, and tonifying kidney yin; the two herbs are the monarch drugs for tonifying the kidney and yin and yang. Fructus Psoraleae has effects of warming and invigorating spleen and kidney; the dioscorea opposita thunb has the functions of tonifying spleen qi, assisting the transportation and transformation of the spleen and continuously breeding food essence, and is a ministerial drug for tonifying the source of kidney essence generation. The pilose antler, the Chinese chive seed, the mulberry fruit, the glossy privet fruit, the raspberry, the Chinese magnoliavine fruit and the dogwood are used as adjuvant drugs for replenishing essence and marrow, dredging kidney qi, warming and nourishing yin of liver and kidney, and the astragalus is used as an essential drug for tonifying spleen qi to play the effects of strengthening spleen and kidney, securing essence, tonifying qi and producing sperm. Dang Gui is a guiding drug for activating blood and tonifying blood, and promoting the blood circulation of reproduction to guide and harmonize the effects of various drugs. The medicines are combined to achieve the effects of nourishing kidney, transforming origin, producing sperm and assisting breeding, and are particularly suitable for patients with kidney-yin deficiency or mild kidney-yang deficiency.

Cortex Cinnamomi is effective for tonifying fire and supporting yang; the cistanche warms and tonifies the kidney yang, the cinnamon and the cistanche are combined with the fructus psoraleae and the Chinese yam as ministerial medicines, the sweet warm yang-invigorating, the essence-blood-nourishing, the essence-blood-tonifying and the yang-invigorating are achieved, and the yang-deficiency physique of the sterile patient is caused by long-term consumption of the body.

The kidney-tonifying and sperm-producing pill has no toxic or side effect, is suitable for patients with kidney-yin deficiency, kidney-yang deficiency and spleen deficiency, and has the advantages of remarkable treatment effect, few raw material types and wide application range.

Detailed Description

The invention will be further illustrated with reference to some specific embodiments.

Example 1

A kidney-tonifying and sperm-producing pill for treating male infertility comprises the following raw material medicines by weight: 15g of herba epimedii, 15g of wolfberry fruit, 10g of raspberry, 5g of semen allii tuberosi, 5g of angelica, 10g of dogwood, 4g of cornu cervi pantotrichum, 3g of schisandra chinensis, 5g of fructus psoraleae, 10g of mulberry, 10g of glossy privet fruit, 15g of astragalus mongholicus and 10g of dioscorea opposita.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility comprises the following steps:

(1) cleaning the above materials, air drying, spreading, and continuously sterilizing with ultraviolet rays for 50-100 min;

(2) uniformly stirring the raw material medicines treated in the step (1), crushing to 150-200 meshes by using a crusher, spreading again, and sterilizing for 50-100min by using ultraviolet rays;

(3) and (3) decocting the polished round-grained rice to be pasty as a matrix, uniformly stirring the ground substance and the medicinal powder obtained in the step (2), making pills with the diameter of 4-6mm on a pharmaceutical machine, and drying in the sun to obtain the traditional Chinese medicine.

Example 2

A kidney-tonifying and sperm-producing pill for treating male infertility comprises the following raw material medicines by weight: 16g of herba epimedii, 15g of wolfberry fruit, 14g of raspberry, 7g of semen allii tuberosi, 6g of angelica, 12g of dogwood, 5g of cornu cervi pantotrichum, 4g of schisandra chinensis, 9g of fructus psoraleae, 12g of mulberry, 11g of glossy privet fruit, 16g of astragalus mongholicus and 12g of dioscorea opposita.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility is described in example 1.

Example 3

A kidney-tonifying and sperm-producing pill for treating male infertility comprises the following raw material medicines by weight: 20g of herba epimedii, 20g of wolfberry fruit, 15g of raspberry, 10g of semen allii tuberosi, 10g of angelica, 15g of dogwood, 6g of cornu cervi pantotrichum, 6g of schisandra chinensis, 10g of fructus psoraleae, 15g of mulberry, 12g of glossy privet fruit, 20g of astragalus mongholicus and 15g of dioscorea opposita.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility is described in example 1.

Example 4

A kidney-tonifying and sperm-producing pill for treating male infertility comprises the following raw material medicines by weight: 24g of herba epimedii, 25g of wolfberry fruit, 15g of raspberry, 12g of semen allii tuberosi, 15g of angelica, 18g of dogwood, 10g of cornu cervi pantotrichum, 8g of schisandra chinensis, 15g of fructus psoraleae, 16g of mulberry, 18g of glossy privet fruit, 25g of astragalus mongholicus and 17g of dioscorea opposita.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility is described in example 1.

Example 5

A kidney-tonifying and sperm-producing pill for treating male infertility comprises the following raw material medicines by weight: 25g of herba epimedii, 25g of wolfberry fruit, 20g of raspberry, 15g of semen allii tuberosi, 15g of angelica, 20g of dogwood, 10g of cornu cervi pantotrichum, 10g of schisandra chinensis, 15g of fructus psoraleae, 20g of mulberry, 20g of glossy privet fruit, 30g of astragalus mongholicus and 20g of dioscorea opposita.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility is described in example 1.

Example 6

A kidney-tonifying and sperm-producing pill (yang-tonifying kidney-nourishing and sperm-producing pill) for treating male infertility comprises the following raw material medicines by weight: 15g of herba epimedii, 15g of wolfberry fruit, 10g of raspberry, 5g of semen allii tuberosi, 5g of angelica, 10g of dogwood, 4g of cornu cervi pantotrichum, 3g of schisandra chinensis, 5g of fructus psoraleae, 10g of mulberry, 10g of glossy privet fruit, 15g of astragalus membranaceus, 10g of dioscorea opposita, 1g of cinnamon and 8g of cistanche.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility is described in example 1.

Example 7

A kidney-tonifying and sperm-producing pill (yang-tonifying kidney-nourishing and sperm-producing pill) for treating male infertility comprises the following raw material medicines by weight: 17g of herba epimedii, 19g of wolfberry fruit, 17g of raspberry, 8g of semen allii tuberosi, 6g of angelica, 13g of dogwood, 5g of cornu cervi pantotrichum, 5g of schisandra chinensis, 8g of fructus psoraleae, 12g of mulberry, 14g of glossy privet fruit, 16g of astragalus membranaceus, 12g of dioscorea opposita, 2g of cinnamon and 12g of cistanche.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility is described in example 1.

Example 8

A kidney-tonifying and sperm-producing pill (yang-tonifying kidney-nourishing and sperm-producing pill) for treating male infertility comprises the following raw material medicines by weight: 20g of herba epimedii, 20g of wolfberry fruit, 15g of raspberry, 10g of semen allii tuberosi, 10g of angelica, 15g of dogwood, 6g of cornu cervi pantotrichum, 6g of schisandra chinensis, 10g of fructus psoraleae, 15g of mulberry, 12g of glossy privet fruit, 20g of astragalus membranaceus, 15g of dioscorea opposita thumb, 3g of cinnamon and 10g of cistanche.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility is described in example 1.

Example 9

A kidney-tonifying and sperm-producing pill (yang-tonifying kidney-nourishing and sperm-producing pill) for treating male infertility comprises the following raw material medicines by weight: 22g of herba epimedii, 21g of wolfberry fruit, 17g of raspberry, 14g of semen allii tuberosi, 10g of angelica, 18g of dogwood, 9g of cornu cervi pantotrichum, 9g of schisandra chinensis, 12g of fructus psoraleae, 17g of mulberry, 16g of glossy privet fruit, 25g of astragalus membranaceus, 17g of dioscorea opposita, 5g of cinnamon and 10g of cistanche.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility is described in example 1.

Example 10

A kidney-tonifying and sperm-producing pill (yang-tonifying kidney-nourishing and sperm-producing pill) for treating male infertility comprises the following raw material medicines by weight: 25g of herba epimedii, 25g of wolfberry fruit, 20g of raspberry, 15g of semen allii tuberosi, 15g of angelica, 20g of dogwood, 10g of cornu cervi pantotrichum, 10g of schisandra chinensis, 15g of fructus psoraleae, 20g of mulberry, 20g of glossy privet fruit, 30g of astragalus membranaceus, 20g of dioscorea opposita, 5g of cinnamon and 15g of cistanche.

The preparation method of the kidney-tonifying and sperm-producing pill for treating male infertility is described in example 1.

Example 11

The sperm-transforming pill matched with the kidney-tonifying sperm-producing pill for treating male infertility, which is described in the embodiment 1 to 10, comprises the following raw materials in parts by weight: 15g of herba epimedii, 15g of wolfberry fruit, 10g of raspberry, 5g of semen allii tuberosi, 5g of angelica, 10g of dogwood, 3g of schisandra chinensis, 10g of mulberry fruit, 10g of glossy privet fruit, 10g of astragalus membranaceus, 10g of dioscorea opposita thumb, 10g of rhizoma anemarrhenae, 10g of phellodendron amurense and 10g of rhizoma smilacis glabrae.

Example 12

The sperm-transforming pill matched with the kidney-tonifying sperm-producing pill for treating male infertility, which is described in the embodiment 1 to 10, comprises the following raw materials in parts by weight: 20g of herba epimedii, 20g of wolfberry fruit, 15g of raspberry, 10g of semen allii tuberosi, 10g of angelica, 15g of dogwood, 6g of schisandra chinensis, 15g of mulberry fruit, 12g of glossy privet fruit, 15g of astragalus membranaceus, 15g of dioscorea opposita thumb, 15g of rhizoma anemarrhenae, 15g of phellodendron amurense and 15g of rhizoma smilacis glabrae.

Example 13

The sperm-transforming pill matched with the kidney-tonifying sperm-producing pill for treating male infertility, which is described in the embodiment 1 to 10, comprises the following raw materials in parts by weight: 25g of herba epimedii, 25g of wolfberry fruit, 20g of raspberry, 15g of semen allii tuberosi, 15g of angelica, 20g of dogwood, 10g of schisandra chinensis, 20g of mulberry fruit, 20g of glossy privet fruit, 20g of astragalus membranaceus, 20g of dioscorea opposita thumb, 20g of rhizoma anemarrhenae, 20g of phellodendron amurense and 20g of rhizoma smilacis glabrae.

Typical cases

1. Yang XX, male, 28 years old, and a woman born in marriage 7 years old, pregnant with two fetuses now, and unemployed for one year. 2019.2.1 when diagnosis comes, there are no time to stop the occurrence of fatigue, weakness, short breath, soreness and weakness of waist and knees, diarrhea due to uncooked food and cold, semen examination: the semen is slightly thick, the semen is not completely liquefied, the liquefaction time is 50 minutes, 9.9 percent of PR, 9.8 percent of NP, 19.7 percent of PR + NP, the survival rate is 23 percent, and the concentration: 3.8 million, total: 0.54 hundred million. The Western diagnosis is: 1. incomplete liquefaction of semen, 2. asthenospermia, 3. oligospermia, and 4. necrospermia. The traditional Chinese medicine diagnosis is as follows: 1. damp-heat in the lower energizer, 2. deficiency of kidney yin, and 3. deficiency of spleen. 1 bottle of sperm-eliminating pill in example 12 and 3 bottles of kidney-tonifying sperm-generating pill in example 3 (first two medicines are taken alternately one day, then only the kidney-tonifying sperm-generating pill is taken) are given to be matched for application, the two medicines are not taken on the same day, 3 times are taken every day, 20 pills are taken each time, the pills are taken half an hour before meals, and one treatment course (one month) is taken. During the period, patients can not be retested in time, the complaint symptom disappears after the retesting at 2019.3.31, and the sperm quality is rechecked: moderate semen viscosity, complete liquefaction of semen at night for 30 minutes, PR: 57.8%, NP 5.7%, PR + NP61.4%, survival rate 73.5%, concentration 4.5 million, total 1.43 million. The kidney-tonifying and sperm-producing pills of the invention example 1 were continuously administered to achieve pregnancy-preparing conditions according to the symptoms of the patient and the sperm assay results, and maintained the therapeutic effect, i.e., the wife was pregnant in the same year at 6 months and a girl was born in the year.

2. Sunwukong XX, male, 28 years old, and married 6 years old with one woman who is pregnant with two fetuses now and is not fertile for one year. 2019.7.8 it is used for half a year after intermittent treatment, manifested as asthenia, short breath, fatigue, soreness of waist and knees, tinnitus, swollen tongue, moist tongue, tooth mark, raw or cold food, diarrhea, and loose stool. Testing semen: the semen is slightly thick, the semen is completely liquefied, the liquefaction time is 40 minutes, PR is 30.85 percent of NP and is 10.17 percent, PR + NP is 41.02 percent, the survival rate is 38 percent, the concentration is 23.29 million, and the total number is: 0.81 hundred million. The Western diagnosis is: 1. asthenozoospermia, 2. necrospermia. The traditional Chinese medicine diagnosis is as follows: 1. deficiency of kidney yin 2, spleen deficiency. The kidney-tonifying and sperm-producing pills of embodiment 3 of the invention are taken in 4 bottles for 3 times a day, 20 pills each time, and about half an hour before meal, and one treatment course (one month) is taken. At 2019.8.26, the symptoms disappear or partially improve, and the sperm quality is reviewed: moderate semen viscosity, complete liquefaction of semen at night for 30 minutes, PR: 53.85%, NP 5.61%, survival rate 76%, concentration 3.03 million, total: 2.43 hundred million. The pregnancy preparation condition is achieved according to the symptoms of the patient and the semen test result, the kidney-tonifying and sperm-producing pill in the embodiment 3 of the invention is continuously administered to maintain the curative effect on that the male in the same year of 10 months is pregnant and a boy is born in the next year.

3. High XX, male, age 27, married 1 year three months uneaten, and pregnant one year later. 2020.5.19 it is indicated for common cold, swollen tongue with teeth mark, cold limbs in winter, general fatigue, weakness, short breath, fatigue, soreness of waist and knees, tinnitus, diarrhea due to uncooked food, and loose stool in general. Testing semen: the semen is clear and thin, the semen is completely liquefied, the liquefaction time is 30 minutes, the PR is 27.88 percent, the NP is 6.19 percent, the PR + NP is 34.04 percent, the survival rate is 35.6 percent, the concentration is 3.56 million, and the total number is as follows: 0.78 hundred million. The Western diagnosis is: 1. asthenozoospermia, 2. necrospermia. The traditional Chinese medicine diagnosis is as follows: 1. the two medicines are taken alternately one day and a day (the two medicines are not taken on the same day) 3 times a day, 20 pills are taken each time, and the medicine is taken half an hour before meals for about one treatment course (one month). At 2020.6.18, the symptoms disappear or partially improve, and the sperm quality is reviewed: moderate semen viscosity, complete liquefaction of semen at night for 30 minutes, PR: 59% NP 10.23%, survival rate 75.3%, concentration 3.39 million, total 1.01 hundred million. According to the symptoms of the patient and the semen test result, 1 bottle of the yang-tonifying kidney-tonifying sperm-producing pills of the embodiment 8 and 3 bottles of the kidney-tonifying sperm-producing pills of the embodiment 5 are continuously administered (the two medicines are taken alternately one day after one day, and then only the kidney-tonifying sperm-producing pills are taken) according to the invention, and the administration maintains the curative effect until the patient is pregnant in the same year of 9 months, and a boy grows one year later.

4. In XX, male was born in 11 years old and married at 33 years old, and female pregnant women and male born are expected to be unemployed for one year. 2020.9.5 it is manifested by asthenia, short breath, susceptibility to common cold, cold limbs in winter, cold sweat in palms, soles and soles, swollen tongue with teeth marks, fatigue, soreness of waist and knees, tinnitus, diarrhea, loose stool, premature ejaculation, and erection weakness. Testing semen: the semen is clear and thin, the semen is completely liquefied, the liquefaction time is 30 minutes, 8.12 percent of PR, 3.42 percent of NP, 11.54 percent of PR + NP, the survival rate is 15.6 percent, the concentration is 2.67 million, and the total number is as follows: 1.15 hundred million. The Western diagnosis is: 1. asthenozoospermia, 2. necrospermia. The traditional Chinese medicine diagnosis is as follows: 1. for kidney yang deficiency, 2 for spleen deficiency and 3 for qi deficiency, 2 bottles of yang-tonifying, kidney-tonifying and sperm-generating pills of example 10 and 2 bottles of kidney-tonifying and sperm-generating pills of example 2 are given, the two pills are alternately taken one day and one day (the two pills are not taken on the same day), the two pills are taken 3 times a day, 20 pills are taken each time, and the pills are taken half an hour or so before meals and are taken for one treatment course (one month). At 2020.10.3, the symptoms disappear or partially improve, and the sperm quality is reviewed: moderate semen viscosity, complete liquefaction of semen at night for 30 minutes, PR: 39.02%, NP 11.22%, survival rate 43.6.3%, concentration 2.35 million, total 0.7 million. According to the symptoms of the patient and the semen test result, 1 bottle of yang-tonifying kidney-tonifying sperm-producing pills in the embodiment 6 of the invention and 3 bottles of kidney-tonifying sperm-producing pills in the embodiment 2 of the invention (the two medicines are taken alternately one day after one round, and then only the kidney-tonifying sperm-producing pills are taken) are continuously taken, and then the patient goes out for the office to follow up the visit and does not respond. At 2021.2.28, when a wife is pregnant through WeChat communication and symptoms relapse before drinking due to busy work and staying overnight, and the body is further conditioned, 2 bottles of the yang-tonifying kidney-tonifying sperm-producing pills of example 7 and 2 bottles of the kidney-tonifying sperm-producing pills of example 2 are given according to the symptoms, and the two medicines are alternately taken one round and one day. After the medicine is taken, the patient can reflect that the physical discomfort symptom disappears, and the follow-up visit is not recurrent till now.

5. Wang XX, male, 21 years old, married for 1 year old, and infertile for one year after pregnancy, diagnosis at 2020.5.3, general fatigue, weakness, short breath, dry mouth, pleased to eat cold drink, night sweat in winter, soreness and weakness of waist and knees, tinnitus, general constipation, scrotum dampness, pruritus and yellow urine. Testing semen: the semen is viscous, the semen is not liquefied, the liquefaction time is 60 minutes, 18.1 percent of PR, 2.7 percent of NP, 20.8 percent of PR + NP, 25.3 percent of survival rate, 22.8 million of concentration and total number: 2.74 hundred million (undiluted semen). The Western diagnosis is: 1. semen not liquefied, 2. asthenospermia, 3. necrospermia. The traditional Chinese medicine diagnosis is as follows: 1. damp-heat in the lower energizer 2, kidney yin deficiency, spleen deficiency 3 and qi deficiency 4. The two pills are taken in turn one day, 3 times a day, 20 pills each time, and about half an hour before meal, and one treatment course (one month) is taken. At 2020.6.15, the physician needs to review the short breath, dry mouth, preference for cold drink, constipation, moist scrotum, pruritus and yellow and better urine, and then take 2 bottles of the sperm-dissolving pill of the invention example 11 and 2 bottles of the kidney-tonifying and sperm-producing pill of the invention example 3, and check the sperm quality at 2020.9.7 for the patient out of office: slightly thick semen, complete liquefaction of semen at night, liquefaction time 45 minutes, PR: 45.8 percent, 23.28 percent of NP, 45.3 percent of survival rate, 4.0 million of concentration and 0.4 hundred million of total number. 1 bottle of the sperm-eliminating pill of example 12 and 3 bottles of the kidney-tonifying sperm-generating pill of example 4 are given (the two pills are alternately taken one day after the other, and then only the kidney-tonifying sperm-generating pill is taken) for one treatment course (one month). Sperm quality was reviewed at 2020.9.30: the semen has moderate viscosity, complete liquefaction of semen, and liquefaction time of 30 minutes PR: 56.4 percent of NP, 10.26 percent of NP, 66.67 percent of PR + NP, 68.2 percent of survival rate, 2.73 million of concentration and 0.82 hundred million of total amount, and the pregnant woman is ordered to start the pregnant woman according to the condition of illness and the examination result. Then the patient is introduced to another hospital in this city to take the traditional Chinese medicine decoction, the pregnancy is kept, and the semen quality is rechecked in the outer hospital at 2020.11.1: the semen is slightly thick, the semen is completely liquefied at night, the liquefaction time is 40 minutes, and the ratio of PR: 19.23% of NP, 19.29% of PR + NP38.52%, survival rate 26.1%, concentration 1.04 million, total 0.1 hundred million. After 11.9 days, my hospital reexamination: the semen is slightly thick, the semen is completely liquefied at night, the liquefaction time is 45 minutes, PR is 17.62 percent, NP is 5.71 percent, PR and NP are 23.33 percent, the survival rate is 24.1 percent, the concentration is 5.3 million, and the total number is 0.79 hundred million. The patient shows the symptoms of excessive internal heat during taking the decoction in the hospital, and according to the description of the patient, the decoction may contain a large amount of thick and greasy yang-tonifying products, which causes the deficient fire of the patient to rise and disturb the seminal emission chamber, causes the seminal generation function of the testis to be damaged, and causes the quality of the sperms to be reduced. After 1 bottle of sperm-eliminating pill in example 13 and 3 bottles of kidney-tonifying sperm-generating pill in example 1 are taken, the two pills are alternately taken one day for one round, and then only the kidney-tonifying sperm-generating pill is taken for one treatment course (one month), and the treatment course is 2021.3.1 days for the reexamination of the hospital: the semen viscosity is moderate, the semen is completely liquefied at night, the liquefaction time is 30 minutes, PR is 52.38%, NP is 14.29%, PR + NP is 66.67%, the survival rate is 72.6%, the concentration is 1.06 million, the total amount is 3.18 hundred million, the effect of the kidney-tonifying and sperm-producing pill in the embodiment 3 of the invention is maintained when a pregnant woman orders to prepare for pregnancy and the male is pregnant at 2021.5, and all indexes are checked to be normal during pregnancy.

6. Yang XX, male, 25 years old, married for 2 years old. 2020.1.30 it is indicated for emaciation, cold limbs in winter, sweating in palms and soles, general fatigue, weakness, susceptibility to common cold, swollen and moist tongue with teeth mark, short breath, no relief of body fatigue after rest, no desire to move, soreness and coldness of waist and knees, tinnitus, sexual impotence, and can be eaten by oral administration of sildenafil to treat cold diarrhea, loose stool in general, clear and profuse urine, frequent nocturia but scanty urine. Testing semen: the semen is clear and thin, the semen is completely liquefied, the liquefaction time is 30 minutes, and the weight ratio of PR to the total weight of the semen is 18.4 percent, NP to the total weight of the semen is 4.72 percent, PR + NP: 23.11%, survival rate 15.6%, concentration 1.67 million, total: 0.5 hundred million. The Western diagnosis is: 1. asthenozoospermia, 2. necrospermia. The traditional Chinese medicine diagnosis is as follows: 1. for kidney yang deficiency, 2 for spleen yang deficiency and 3 for qi deficiency, 2 bottles of yang-tonifying, kidney-tonifying and sperm-producing pills 8 in the embodiment of the invention are given, 3 times a day, 20 pills each time, and the pills are taken half an hour before meals. Order to stop sildenafil during the administration period and suspend the room, so as to facilitate the accumulation of the drug effect and regulate the body functions. When the complaints of the disease are improved in the 2020.2.15 double-diagnosis, 2 bottles of yang-tonifying, kidney-tonifying and sperm-producing pills of the embodiment 9 of the invention are taken 3 times a day, 20 pills each time, and about half an hour before meals. At 2020.3.1, the physician feels more energetic and has an erection at night and an erection in the morning, and then reviews the sperm quality: moderate semen viscosity, complete liquefaction of semen at night for 30 minutes, PR: 34.55 percent, NP is 6.36 percent, the survival rate is 46.3 percent, the concentration is 6.95 million, and the total number is 0.73 hundred million. The patient continues to take the pill 3 bottles of the pill for tonifying yang, tonifying the kidney and generating sperm according to the symptoms of the patient and the sperm test result, the wife is slightly believed to be pregnant at 2021.5.19, and the pregnancy examination of follow-up shows that all indications are normal.

Finally, the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting, and other modifications or equivalent substitutions made by the technical solutions of the present invention by those of ordinary skill in the art should be covered within the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solutions of the present invention.