阅读说明：本技术 抗无包膜病毒型的抗病毒剂和含有其的组合物以及抗病毒制品及其制造方法 (Antiviral agent against non-enveloped virus, composition containing same, antiviral product, and method for producing same ) 是由 丹羽惠 山田喜直 于 2019-10-31 设计创作，主要内容包括：本发明的目的是提供一种适于使无包膜病毒失活的抗病毒剂和含有其的组合物以及抗病毒制品及其制造方法。本发明的抗无包膜病毒型的抗病毒剂含有选自下述成分中的至少1种：(A)含有Al元素、Mg元素和O元素的化合物,(B)含有碱金属元素或碱土金属元素、Si元素和O元素的化合物,以及(C)含有2价金属元素的氢氧化物。(The purpose of the present invention is to provide an antiviral agent suitable for inactivating non-enveloped viruses, a composition containing the same, an antiviral product, and a method for producing the same. The antiviral agent against non-enveloped virus of the present invention contains at least 1 selected from the following components: (A) a compound containing an Al element, an Mg element, and an O element, (B) a compound containing an alkali metal element or an alkaline earth metal element, an Si element, and an O element, and (C) a hydroxide containing a 2-valent metal element.)

1. An antiviral agent against non-enveloped viruses, characterized by containing at least 1 selected from the following components:

(A) a compound containing an Al element, an Mg element and an O element,

(B) a compound containing an alkali metal element or an alkaline earth metal element, an Si element and an O element, and

(C) a hydroxide containing a 2-valent metal element.

2. The non-enveloped virus-type antiviral agent according to claim 1, wherein said compound (A) is a compound represented by the following formula (1),

Mg_xAl_yO_(x+1.5y) (1)

wherein x and y are integers.

3. The non-enveloped virus-type antiviral agent according to claim 1 or 2, wherein said compound (B) is a silicate.

4. The non-enveloped virus-type antiviral agent according to claim 1 to 3, wherein the hydroxide (C) is a compound containing an alkaline earth metal element.

5. An antiviral agent comprising the non-enveloped virus-resistant antiviral agent according to any one of claims 1 to 4.

6. A coating composition characterized by comprising:

an antiviral agent against non-enveloped virus type as claimed in any one of claims 1 to 4, and

a binder resin.

7. A method for producing an antiviral product, comprising the steps of:

a step of forming a coating film on the surface of a substrate by using the coating composition according to claim 6 and the substrate, and

and drying the coating film.

Technical Field

The present invention relates to an antiviral agent suitable for inactivating non-enveloped viruses, a composition containing the same, an antiviral product, and a method for producing the same.

Background

Viral diseases caused by influenza virus, norovirus, and the like have become a major problem worldwide, and have gradually come to be highly conscious of health in daily life.

Viruses are roughly classified into 2 types according to the presence or absence of an envelope in their structure, influenza viruses are enveloped viruses with an envelope, and norovirus is non-enveloped viruses without an envelope.

Conventionally, for inactivating viruses, a method of killing viruses by the following treatment or the like is generally known: heat treatment, treatment with an organic solvent such as ethanol, treatment with a surfactant, and the like. These methods are known to be particularly effective inactivation treatments for enveloped viruses. However, non-enveloped viruses are resistant to such treatments and cannot be expected to be as effective as enveloped viruses.

Therefore, in recent years, antiviral agents that inactivate non-enveloped viruses have been vigorously developed.

Patent document 1 discloses a compound containing [ M ]²⁺ _1-xM³⁺ _x(OH)₂][A^n- _x/n·mH₂O](in the formula, M²⁺Represents a 2-valent metal ion, M³⁺Represents a 3-valent metal ion, A^n- _x/nDenotes an interlayer anion, 0<x<1, n represents the valence of A, 0. ltoreq. m<1) Hydrotalcite-fiber composite represented andthe method for producing the same is described therein that the complex has low antiviral properties, and the performance is improved when the complex is treated with a thiosulfate solution of copper.

Patent document 2 discloses an antiviral membrane containing a silicon-containing compound (a siloxane compound or the like) and having a membrane surface pH of 6 or less.

Patent document 3 discloses an antiviral composition containing silver and a polyalkylene biguanide compound having a specific structure and/or a salt thereof.

Documents of the prior art

Patent document

Patent document 1: international publication No. 2018/30521

Patent document 2: international publication No. 2017/86098

Patent document 3: japanese laid-open patent publication No. 2015-78132

Disclosure of Invention

Problems to be solved by the invention

The purpose of the present invention is to provide an antiviral agent suitable for inactivating non-enveloped viruses, a composition containing the same, an antiviral product, and a method for producing the same.

Means for solving the problems

The present invention is as follows.

1. An antiviral agent against non-enveloped viruses, characterized by containing at least one selected from the group consisting of: (A) a compound containing an Al element, an Mg element, and an O element, (B) a compound containing an alkali metal element or an alkaline earth metal element, an Si element, and an O element, and (C) a hydroxide containing a 2-valent metal element.

2. The non-enveloped virus-type antiviral agent according to item 1 above, wherein the compound (A) is a compound represented by the following formula (1),

Mg_xAl_yO_(x+1.5y) (1)

(wherein x and y are integers.)

3. The non-enveloped virus-type antiviral agent according to item 1 or 2 above, wherein the compound (B) is a silicate.

4. The non-enveloped virus-type antiviral agent according to any one of items 1 to 3, wherein the hydroxide (C) is a compound containing an alkaline earth metal element.

5. An antiviral product comprising the non-enveloped virus-resistant antiviral agent according to any one of items 1 to 4.

6. A coating composition comprising the non-enveloped virus-resistant antiviral agent according to any one of items 1 to 4 and a binder resin.

7. A method for producing an antiviral product, comprising the steps of: a step of forming a coating film on the surface of the substrate by using the coating composition and the substrate described in the above item 6, and a step of drying the coating film.

Effects of the invention

The antiviral agent against non-enveloped viruses, the composition and the antiviral preparation containing the same according to the embodiments of the present invention are suitable for inactivation of non-enveloped viruses.

Detailed Description

The antiviral agent against non-enveloped virus type according to the embodiment of the present invention contains at least 1 selected from the following components: (A) a compound containing an Al element, an Mg element, and an O element, (B) a compound containing an alkali metal element or an alkaline earth metal element, an Si element, and an O element, and (C) a hydroxide containing a 2-valent metal element. The hydroxide (C) is a compound containing no 3-valent metal element and no Si element.

The antiviral agent against non-enveloped viruses according to the embodiment of the present invention may be any of 1 kind of compound (a), compound (B) and hydroxide (C), or a combination of 2 kinds or a combination of 3 kinds thereof.

Examples of viruses that can be inactivated by the non-enveloped virus-type antiviral agent according to the embodiment of the present invention include: norovirus, adenovirus, rotavirus, human papilloma virus, poliovirus, enterovirus, coxsackievirus, human parvovirus, encephalomyocarditis virus, poliovirus, rhinovirus and the like.

The compound (A) is a compound containing an Al element, an Mg element and an O element. The compound may be any of an oxide, a hydroxide, a nitrate, a sulfate, a phosphate or other inorganic acid salt, an acetate or other organic acid salt, and a complex. Among them, oxides and hydroxides are preferable, and oxides are particularly preferable.

Examples of the oxide include compounds represented by the following general formula (1).

Mg_xAl_yO_(x+1.5y) (1)

(wherein x and y are integers.)

In the above general formula (1), the relationship between x and y is preferably x > y.

Examples of the hydroxide include compounds represented by the following general formula (2).

[M²⁺ _1-pM³⁺ _p(OH)₂]^q+[A^n- _p/n·mH₂O]^q- (2)

(in the formula, M²⁺Is a 2-valent metal ion, M³⁺Is a 3 valent metal ion, A^n- _p/nIs an interlayer anion, 0<p is less than or equal to 0.33, n is the valence number of A, m is less than or equal to 0<1。)

In the above general formula (2), as M²⁺Examples thereof include Mg²⁺Ion, Ca²⁺Ion, Ba²⁺Ions, and the like. In addition, as M³⁺Examples thereof include Fe³⁺Ions, Al³⁺Ion, La³⁺Ions, and the like.

As the compound represented by the above general formula (2), M is preferred²⁺Is Mg²⁺Ionic and M³⁺Is Al³⁺An ionic compound.

The compound (B) is a compound containing an alkali metal element or an alkaline earth metal element, an Si element and an O element. Examples of the alkali metal element include Li element, Na element, K element, Rb element, Cs element, Fr element, and the like. Among them, Na element is preferable.

The compound (B) is preferably a silicate, more preferably sodium silicate. As sodium silicate, Na is known₂SiO₃、Na₄SiO₄、Na₂Si₂O₅、Na₂Si₄O₉Etc., among them, Na is preferred₂Si₂O₅。

The hydroxide (C) is a compound containing a metal element having a valence of 2. The 2-valent metal element includes group 2 elements (Be element, Ca element, Sr element, Ba element, Ra element, etc.), Cu element, Ni element, Co element, Zn element, Ge element, etc. in the periodic table. Among them, alkaline earth metal elements are preferable, and Ca element is particularly preferable.

The hydroxide (C) is preferably calcium hydroxide.

The antiviral agent against non-enveloped viruses according to the embodiment of the present invention can be used as it is, and can be applied to a liquid preparation (aerosol) dispersed in a medium, or a coating composition in which an antiviral agent against non-enveloped viruses is applied to the surface of a substrate having a predetermined shape and dried to add the same. The complex in which the non-enveloped virus-resistant antiviral agent is added to the surface of the base material is an example of an antiviral product described later.

The non-enveloped virus-resistant antiviral agent according to the embodiment of the present invention can be suitably used for a resin composition for molding processing that further contains a resin or a precursor thereof. Then, molding processing for forming a predetermined shape may be performed to obtain a molded article containing the non-enveloped virus-resistant antiviral agent. Such a molded article is an example of an antiviral article described later.

As described above, when the antiviral agent against non-enveloped viruses according to the embodiment of the present invention is applied to a coating composition or a resin composition, it is preferable that the particle size is small. The upper limit of the particle diameter is preferably 30 μm, more preferably 10 μm, and the lower limit is preferably 50nm, more preferably 100 nm. The shape of the particles is not particularly limited.

The coating composition according to the embodiment of the present invention contains an antiviral agent against non-enveloped virus and a binder resin. The medium of the coating composition may be water, an organic solvent, or a mixture thereof, and is preferably water or a mixture of water and a water-soluble organic solvent.

The number of binder resins contained in the coating composition according to the embodiment of the present invention may be only 1, or may be 2 or more.

The binder resin may be appropriately selected depending on the kind of the medium, and when the medium is water or a mixture of water and a water-soluble organic solvent, the binder resin may be either a water-soluble resin or a water-insoluble resin. Examples of the binder resin include acrylic resins, ethylene-vinyl acetate copolymers or modified products thereof (acid-modified products and the like), ethylene-vinyl chloride copolymers, vinyl chloride-vinyl acetate copolymers, polyvinyl acetate, polyvinyl chloride, modified olefin resins (chlorinated polyolefins and the like), polyester resins, urethane resins, styrene-butadiene copolymers, styrene-isoprene copolymers, styrene-butadiene-styrene block copolymers, styrene-ethylene-butylene-styrene block copolymers, styrene-ethylene-propylene-styrene block copolymers, hydrogenated styrene-butadiene-styrene block copolymers, hydrogenated styrene-ethylene-butylene-styrene block copolymers, styrene-ethylene-propylene-styrene block copolymers, styrene-ethylene-butylene-styrene block copolymers, styrene, Hydrogenated styrene-ethylene-propylene-styrene block copolymers, and the like. Among them, acrylic resins are preferable.

The content ratio of the binder resin contained in the coating composition of the embodiment of the present invention is preferably 10 to 200 parts by mass, more preferably 10 to 150 parts by mass, and still more preferably 20 to 100 parts by mass, based on 100 parts by mass of the non-enveloped virus-resistant antiviral agent.

The coating composition according to the embodiment of the present invention may contain additives such as a dispersant, a viscosity modifier, an antifoaming agent, a coloring agent, a fragrance, and a preservative.

From the viewpoint of effectively inactivating non-enveloped viruses in the obtained antiviral product, the content of the non-enveloped virus-resistant antiviral agent contained in the coating composition according to the embodiment of the present invention is preferably 0.5 to 50% by mass, more preferably 1 to 40% by mass, and still more preferably 1 to 30% by mass.

Hereinafter, a method for producing an antiviral product in which an antiviral agent against non-enveloped viruses is added to the surface of a substrate using the coating composition of the embodiment of the present invention will be described.

The manufacturing method for manufacturing the antiviral product comprises the following steps: a step of applying the coating composition to a substrate to form a coating film (hereinafter, also referred to as "application step"), and a step of drying the formed coating film (hereinafter, also referred to as "drying step").

The substrate is not particularly limited, and any material containing an inorganic material, an organic material, or a combination thereof may be used, and the shape thereof is not particularly limited. As the above-mentioned base material, there can be used: resin molded articles (including foamed resin molded articles) such as films, pellets and general molded articles, fibers, fiber products such as nonwoven fabrics and woven fabrics containing fibers, and the like.

In the coating step, dip dyeing (padding), dipping, coating, spraying, printing, and the like can be used. In the coating step, single-layer coating or multi-layer coating may be performed depending on the shape of the substrate.

In the drying step, the medium is removed from the coating film by a method such as sealing heating or hot air heating depending on the shape of the substrate, and a coating film containing the non-enveloped virus-resistant antiviral agent can be formed. Thus, an antiviral product having the coating film on the surface of the base material can be obtained.

The antiviral preparation against non-enveloped viruses according to the embodiment of the present invention is a preparation containing at least 1 selected from the compounds (a), (B), and (C).

Products obtained by using the coating composition as described above and molded products obtained by supplying a resin composition containing an anti-non-enveloped virus antiviral agent and a resin or a precursor thereof to a conventionally known molding method are suitable examples of the anti-non-enveloped virus antiviral product. The latter resin composition may be either a thermoplastic resin composition or a curable resin composition. In addition, when a part of the non-enveloped virus-resistant antiviral agent is exposed on the surface of the obtained resin molded product, the inactivation effect on non-enveloped viruses is excellent.

The invention is used in the fields of industry, washing, medical treatment, food and the like. Specific examples of the antiviral agent against non-enveloped viruses include: films (packaging films, decorative films, packaging bags, etc.), papers (wallpaper, sealing paper, etc.), filters (filters for air cleaners, air conditioning filters, etc.), masks, handbags, stationery, tableware, cookware, trays, racks, doors, railings, handrails, tables, chairs, sofas, brushes, clothing, sporting goods, leather slings, housings for electrical products, and the like.

Examples

Hereinafter, embodiments of the present invention will be described more specifically with reference to examples, but the present invention is not limited to these examples.

1. Antiviral agent against non-enveloped virus

Antiviral agents V1 to V6 containing the following components were used.

(1)V1

Calcined hydrotalcite (chemical formula: Mg) having a particle diameter of 0.1 to 30 μm as measured by a laser diffraction particle size distribution meter₇Al₃O_11.5The expressed complex oxide) powder.

(2)V2

Sodium silicate (chemical formula: Na) having a particle diameter of 0.1 to 30 μm as measured by a laser diffraction particle size distribution meter₂Si₂O₅The indicated silicate) powder.

(3)V3

Calcium hydroxide powder having a particle diameter of 0.1 to 30 μm as measured by a laser diffraction particle size distribution meter.

(4)V4

Mica powder having a particle diameter of 0.1 to 30 μm as measured by a laser diffraction particle size distribution meter.

(5)V5

MFI-type zeolite (Na-type) powder having a particle diameter of 0.1 to 30 μm as measured by a laser diffraction particle size distribution meter.

(6)V6

MFI-type zeolite (H-type) powder having a particle diameter of 0.1 to 30 μm as measured by a laser diffraction particle size distribution meter.

2. Evaluation of antiviral agent against non-enveloped virus type

Examples 1 to 3 and comparative examples 1 to 3

The performance of each antiviral agent was evaluated by the method shown in JIS L1922 (method for testing antiviral properties of fiber products), and the antiviral properties were determined from the obtained antiviral activity value (Mv). The evaluation was classified into: when the Mv is more than 3 and is more than or equal to 2.0, the effect is exerted, and when the Mv is more than or equal to 3.0, the effect is sufficient.

Purified water was added to the antiviral agent to a concentration of 0.1% by mass. Then, a virus infection titer (virus infection titer) of 1 to 5X 10 is added to 900. mu.L of the liquid⁷PFU/mL of cat calicivirus solution (100. mu.L) was added, and the mixture was allowed to stand at 25 ℃ for 2 hours. The mixture was then recovered and subjected to plaque number assay to determine viral infectious titer. The virus infection titer was measured in the same manner as in the test sample except that 900. mu.L of Phosphate Buffered Saline (PBS) was used as a control sample instead of the test sample.

The performance of antiviral agents was evaluated by the antiviral activity value (Mv) obtained by the following formula. The results are shown in Table 1.

Mv ═ Log (viral infection titer of control sample) -Log (viral infection titer of test sample)

[ Table 1]

	Antiviral agents	Antiviral Activity value Mv
			Example 1	V1: calcined hydrotalcite	2.5
Example 2	V2: sodium silicate	3.2
			Example 3	V3: calcium hydroxide	4.2
Comparative example 1	V4: mica	0.4
			Comparative example 2	V5: MFI type zeolite (Na type)	0.3
Comparative example 3	V6: MFI type zeolite (H type)	0.3

As can be seen from table 1, examples 1, 2 and 3 using antiviral agents V1, V2 and V3 showed excellent antiviral properties.

3. Production of antiviral product against non-enveloped virus

Example 4

Mixing the antiviral agent V1 with a binder containing an acrylic resin (as a binder resin) and water (as a medium) such that the mass ratio of the antiviral agent to the binder resin is 1: 1, to produce a coating composition. Then, the unit area weight was 25g/m²The polyester cloth of (2) is immersed in the coating composition. Then, the mixture was dried at 130 ℃ to prepare an antiviral agent V1 in an amount of 3g/m²The antiviral processing cloth.

Example 5

An antiviral processing cloth was produced in the same manner as in example 4, except that antiviral agent V2 was used instead of antiviral agent V1.

Example 6

An antiviral processing cloth was produced in the same manner as in example 4, except that antiviral agent V3 was used instead of antiviral agent V1.

Industrial applicability

The antiviral agent against non-enveloped viruses and the antiviral product against non-enveloped viruses containing the same according to the present invention are suitable for inactivation of non-enveloped viruses such as norovirus, and are used in the fields of industry, washing, medical care, food, and the like.

The antiviral agent against non-enveloped viruses can be used not only as a raw material for producing an antiviral product against non-enveloped viruses, but also can inactivate viruses by bringing the product into contact with viruses already attached to the product.