阅读说明：本技术 一种保湿修护面霜及其制备方法 (Moisturizing and repairing face cream and preparation method thereof ) 是由 刘念宁 徐卫东 聂开品 方随换 袁仲喜 雷冬梅 于 2021-01-13 设计创作，主要内容包括：本发明涉及一种保湿修护面霜及其制备方法,该面霜由水45-55％、辛酸/癸酸甘油三酯15-25％、丙二醇5-8％、鲸蜡硬脂醇橄榄油酸酯2.5-5.5％、山梨坦橄榄油酸酯1.5-3％、角鲨烷1.5-3％、生育酚乙酸酯1-3％、甘油5-9％、牛油果树果脂1-2％、尿素1-3％、透明质酸钠0.5-1.5％、维生素B30.1-0.5％、乙酰壳糖胺0.1-0.3％、泛酸钙0.05-0.15％、柠檬酸钠0.04-0.10％、腺苷0.005-0.015％、乳酸0.005-0.013％、神经酰胺30.001-0.006％组成；通过称取不同的组分,分别制备成四个不同的混合物,再合并混合物,用集热式磁力搅拌器搅拌均匀,即得保湿修护面霜。该面霜具有皮肤修护、补水、保湿、美白、抗皱等优点,且制备工艺简单,对设备要求低,适合工业化生产。(The invention relates to a moisturizing and repairing face cream and a preparation method thereof, the face cream is composed of water 45-55%, caprylic/capric triglyceride 15-25%, propylene glycol 5-8%, cetearyl alcohol olive oleate 2.5-5.5%, sorbitan olive oleate 1.5-3%, squalane 1.5-3%, tocopherol acetate 1-3%, glycerol 5-9%, shea butter 1-2%, urea 1-3%, sodium hyaluronate 0.5-1.5%, vitamin B30.1-0.5%, acetyl chitosamine 0.1-0.3%, calcium pantothenate 0.05-0.15%, sodium citrate 0.04-0.10%, adenosine 0.005-0.015%, lactic acid 0.005-0.013%, and ceramide 30.001-0.006%; the moisturizing and repairing facial cream is prepared by weighing different components, preparing four different mixtures respectively, combining the mixtures, and uniformly stirring the mixtures by using a heat collection type magnetic stirrer. The cream has the advantages of skin repair, water replenishing, moisture keeping, whitening, wrinkle resisting and the like, and is simple in preparation process, low in equipment requirement and suitable for industrial production.)

1. A moisturizing and repairing cream is characterized by consisting of water, caprylic/capric triglyceride, propylene glycol, cetearyl olive oleate, sorbitan olive oleate, squalane, tocopherol acetate, glycerol, shea butter, urea, sodium hyaluronate, vitamin B3, acetyl chitosamine, calcium pantothenate, sodium citrate, adenosine, lactic acid and ceramide 3.

2. The moisturizing repair cream of claim 1, wherein the moisturizing repair cream consists of the following percentages: 45-55% of water, 15-25% of caprylic/capric triglyceride, 5-8% of propylene glycol, 2.5-5.5% of cetearyl olive oleate, 1.5-3% of sorbitan olive oleate, 1.5-3% of squalane, 1-3% of tocopherol acetate, 5-9% of glycerol, 1-2% of shea butter, 1-3% of urea, 0.5-1.5% of sodium hyaluronate, 30.1-0.5% of vitamin B, 0.1-0.3% of acetyl chitosamine, 0.05-0.15% of calcium pantothenate, 0.04-0.10% of sodium citrate, 0.005-0.015% of adenosine, 0.005-0.013% of lactic acid and 0.006% of ceramide 30.001-0.006%.

3. The moisturizing repair cream of claim 2, wherein the moisturizing repair cream consists of the following percentages: 48-53% of water, 18-23% of caprylic/capric triglyceride, 6-7% of propylene glycol, 3-4% of cetearyl olive oleate, 2-2.5% of sorbitan olive oleate, 1.8-2.5% of squalane, 1.5-2.5% of tocopherol acetate, 6-8% of glycerol, 1.2-1.8% of shea butter, 1.5-2.5% of urea, 0.8-1.2% of sodium hyaluronate, 30.2-0.4% of vitamin B, 0.15-0.25% of acetyl chitosamine, 0.08-0.12% of calcium pantothenate, 0.06-0.08% of sodium citrate, 0.008-0.012% of adenosine, 0.007-0.010% of lactic acid and 30.003-0.004% of ceramide.

4. The moisturizing repair cream of claim 3, wherein the moisturizing repair cream consists of the following percentages: water 50.613%, caprylic/capric triglyceride 20.5%, propylene glycol 6.5%, cetearyl olive oleate 3.25%, sorbitan olive oleate 2.25%, squalane 2.2%, tocopherol acetate 2%, glycerol 7.49%, shea butter 1.5%, urea 2%, sodium hyaluronate 1%, vitamin B30.3%, acetyl chitosamine 0.2%, calcium pantothenate 0.1%, sodium citrate 0.075%, adenosine 0.01%, lactic acid 0.009%, ceramide 30.003%.

5. The moisturizing and repairing cream as claimed in any one of claims 1 to 4, wherein the moisturizing and repairing cream is prepared by:

1) taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 25-35min to obtain a first mixture;

2) putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 40-60 ℃ for 15-25min, taking out, and cooling to room temperature to obtain a second mixture;

3) putting water in a glass container according to the weight percentage, heating the water to the temperature of 60-90 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain a third mixture;

4) uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV;

5) and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

6. The moisturizing and repairing cream as claimed in claim 5, wherein the moisturizing and repairing cream is prepared by the following steps:

1) taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 28-32min to obtain a first mixture;

2) putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in a water bath at 45-55 ℃ for 18-22min, taking out, and cooling to room temperature to obtain a second mixture;

3) putting water in a glass container according to the weight percentage, heating the water to the temperature of 65-85 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain a third mixture;

4) uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV;

5) and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

7. The moisturizing and repairing cream as claimed in claim 6, wherein the moisturizing and repairing cream is prepared by the following steps:

1) taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 30min to obtain a first mixture;

2) putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 50 ℃ for 20min, taking out, and cooling to room temperature to obtain a second mixture;

3) putting water in a glass container according to the weight percentage, heating the water to the temperature of 75 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to the room temperature to obtain a third mixture;

4) uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV;

5) mixing the first mixture, the second mixture, the third mixture and the fourth mixture, stirring the mixture uniformly by using a heat collection type magnetic stirrer until uniform emulsion is formed, and then placing the emulsion into an ultraviolet sterilization box for sterilization treatment to obtain the moisturizing and repairing facial cream.

8. The moisturizing and repairing cream according to claims 5 to 7, wherein the moisturizing and repairing cream is prepared in step 5) by sterilizing for 15 to 25 min.

9. The moisturizing and repairing cream according to claim 8, wherein the sterilizing treatment time in the moisturizing and repairing cream preparing step 5) is 20 min.

10. The moisturizing and repairing cream according to any one of claims 1 to 4, wherein the moisturizing and repairing cream is used for skin repairing, moisturizing, whitening and anti-wrinkle.

Technical Field

The invention relates to the technical field of cosmetics, in particular to a moisturizing and repairing facial cream and a preparation method thereof.

Background

With the development of modern science and technology, the living standard of people rises, and the aesthetic concept of people is more intense. Meanwhile, people have higher and higher requirements on cosmetics, and health, safety and effectiveness are the most important requirements of consumers. In the current state of development of cosmetics, many purchasers mainly buy the cosmetics due to skin care and repair. Then, the trend of cosmetics is to repair problematic skin and care skin-based products.

Application No. CN201811493943.7, a pure natural light blue emulsion containing a liquid crystal phase and a preparation method and application thereof, discloses a pure natural light blue emulsion containing a liquid crystal phase, which comprises deep sea water extract, magnolia officinalis extract, emulsifier and grease, wherein the weight ratio of the deep sea water to the magnolia officinalis extract to the emulsifier to the grease is 60-90: 0.01-0.1: 3-10: 0.1-5. The deep sea water extract, the magnolia bark extract, the emulsifier and the grease are designed according to a specific weight ratio, the lower alcohol, the thickening agent, the acid-base regulator and the nonionic surfactant are added according to specific weight parts, and the pure natural light blue emulsion matrix containing the liquid crystal phase is prepared by the synergistic cooperation of the components, has pure natural light blue and liquid crystal phase on the basis of the efficacy of keeping the skin wet and constructing healthy skin, provides trace elements for the skin and is easy to be absorbed by the skin, and the efficacy components can slowly release through the skin to reach the deep layer of the skin, so that the deep sea water emulsion matrix can be widely applied to cosmetics and hair washing products.

Problem with application No. CN 201811493943.7: 1. can not be completely absorbed by the skin and can not permeate into the skin, thereby causing oil outside the skin and no ventilation; 2. internal dryness, which causes dry and skinned skin, is the drier the vicious circle.

Application No. CN201410036972.6, a jade additive and a preparation method thereof, and a cosmetic and a preparation method thereof, disclose that jade is crushed to obtain jade powder; mixing jade powder and water according to the mass ratio of 1: 3-1: 5, distilling the mixture of the jade powder and water at the temperature of 80-120 ℃ for 10-30 minutes, stopping distillation, and collecting distillate; mixing the distilled residue with the distillate, adding weakly alkaline anion water, and wet grinding to obtain jade additive containing particles with nanometer particle size. The particles in the jade additive prepared by the preparation method of the jade additive are nano-scale and are easier to be absorbed by skin.

Problem with application No. CN 201410036972.6: 1. is not easy to absorb; 2. irritate the skin, which can lead to allergic dermatitis. 3. The long-term use causes skin abnormality and changes the melanocyte to increase; 4. the preparation method is complex.

Application No. CN202010294716.2 discloses a moisturizing and soothing donkey-hide gelatin cream and a preparation method thereof, and discloses the moisturizing and soothing donkey-hide gelatin cream which is prepared from butanediol, xanthan gum, p-hydroxyacetophenone, hexanediol, allantoin, dipotassium glycyrrhizinate, disodium EDTA, glycerol, water/glycerol/glyceryl acrylate/acrylic acid copolymer/propylene glycol, arginine, acetyl chitosamine, glyceryl stearate/PEG-100 stearate, cetostearyl alcohol, glyceryl stearate, beeswax, microcrystalline wax, phytosterol canola oil glycerides, stearic acid, tocopheryl acetate, polysorbate, sorbitan sesquioleate, octyldodecanol, jojoba seed oil, caprylic capric triglyceride, cetyl ethyl hexanoate, cyclopenta dimethyl siloxane/vinyl dimethyl siloxane cross-linked polymer, The cream comprises cyclopentadimethylsiloxane, carbomer, collagen extract, placental protein and water, and discloses a preparation method of the cream.

Problem with application No. CN 202010294716.2: 1. incompatible with skin, resulting in greasy and non-textured skin; 2. not easy to be absorbed, has no nasal extensibility, and has effects of lubricating and softening skin. 3. Can cause acne after long-term use.

In order to solve the technical problems, the inventor researches a novel skin care product which has the characteristics of no toxicity, no stimulation, compatibility with human skin, no greasiness, improved extensibility, lubrication and skin softening effects, has the function of filtering ultraviolet light, is suitable for various skins, does not block pores, does not cause acne, is more suitable for skin management, has a simple production process and low requirements on equipment, and is suitable for industrial production.

Disclosure of Invention

The invention aims to provide a moisturizing and repairing facial cream.

The invention also aims to provide a preparation method of the moisturizing and repairing cream.

Another object of the invention is the use of the developed composition for skin repair, moisturizing, whitening, anti-wrinkle.

The moisturizing and repairing cream disclosed by the invention is composed of water, caprylic/capric triglyceride, propylene glycol, cetearyl olive oleate, sorbitan olive oleate, squalane, tocopherol acetate, glycerol, shea butter, urea, sodium hyaluronate, vitamin B3, acetyl chitosamine, calcium pantothenate, sodium citrate, adenosine, lactic acid and ceramide 3.

The moisturizing and repairing facial cream disclosed by the invention comprises the following components in percentage by weight: 45-55% of water, 15-25% of caprylic/capric triglyceride, 5-8% of propylene glycol, 2.5-5.5% of cetearyl olive oleate, 1.5-3% of sorbitan olive oleate, 1.5-3% of squalane, 1-3% of tocopherol acetate, 5-9% of glycerol, 1-2% of shea butter, 1-3% of urea, 0.5-1.5% of sodium hyaluronate, 30.1-0.5% of vitamin B, 0.1-0.3% of acetyl chitosamine, 0.05-0.15% of calcium pantothenate, 0.04-0.10% of sodium citrate, 0.005-0.015% of adenosine, 0.005-0.013% of lactic acid and 0.006% of ceramide 30.001-0.006%.

Preferably, the moisturizing and repairing cream disclosed by the invention consists of the following components in percentage by weight: 48-53% of water, 18-23% of caprylic/capric triglyceride, 6-7% of propylene glycol, 3-4% of cetearyl olive oleate, 2-2.5% of sorbitan olive oleate, 1.8-2.5% of squalane, 1.5-2.5% of tocopherol acetate, 6-8% of glycerol, 1.2-1.8% of shea butter, 1.5-2.5% of urea, 0.8-1.2% of sodium hyaluronate, 30.2-0.4% of vitamin B, 0.15-0.25% of acetyl chitosamine, 0.08-0.12% of calcium pantothenate, 0.06-0.08% of sodium citrate, 0.008-0.012% of adenosine, 0.007-0.010% of lactic acid and 30.003-0.004% of ceramide.

Further preferably, the moisturizing and repairing cream disclosed by the invention consists of the following components in percentage by weight: water 50.613%, caprylic/capric triglyceride 20.5%, propylene glycol 6.5%, cetearyl olive oleate 3.25%, sorbitan olive oleate 2.25%, squalane 2.2%, tocopherol acetate 2%, glycerol 7.49%, shea butter 1.5%, urea 2%, sodium hyaluronate 1%, vitamin B30.3%, acetyl chitosamine 0.2%, calcium pantothenate 0.1%, sodium citrate 0.075%, adenosine 0.01%, lactic acid 0.009%, ceramide 30.003%.

The preparation method of the moisturizing and repairing face cream comprises the following steps:

1) taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 25-35min to obtain a first mixture;

2) putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 40-60 ℃ for 15-25min, taking out, and cooling to room temperature to obtain a second mixture;

3) putting water in a glass container according to the weight percentage, heating the water to the temperature of 60-90 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain a third mixture;

4) uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV;

5) and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

Preferably, the preparation method of the moisturizing and repairing facial cream comprises the following steps:

1) taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 28-32min to obtain a first mixture;

2) putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in a water bath at 45-55 ℃ for 18-22min, taking out, and cooling to room temperature to obtain a second mixture;

3) putting water in a glass container according to the weight percentage, heating the water to the temperature of 65-85 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain a third mixture;

4) uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV;

5) and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

Further preferably, the preparation method of the moisturizing and repairing cream comprises the following steps:

1) taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 30min to obtain a first mixture;

2) putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 50 ℃ for 20min, taking out, and cooling to room temperature to obtain a second mixture;

3) putting water in a glass container according to the weight percentage, heating the water to the temperature of 75 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to the room temperature to obtain a third mixture;

4) uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV;

5) mixing the first mixture, the second mixture, the third mixture and the fourth mixture, stirring the mixture uniformly by using a heat collection type magnetic stirrer until uniform emulsion is formed, and then placing the emulsion into an ultraviolet sterilization box for sterilization treatment to obtain the moisturizing and repairing facial cream.

The moisturizing and repairing face cream is prepared in the step 5), and the sterilization treatment time is 20 min.

The moisturizing and repairing facial cream disclosed by the invention is applied to the aspects of skin repairing, moisturizing, whitening and wrinkle resisting.

The invention has the following beneficial effects:

1. overcomes the defects of complicated preparation process, difficult absorption and skin irritation, allergic dermatitis, melanocyte increase and acne caused by long-term use of the prior art.

2. The cream overcomes the defects that the cream in the prior art is incompatible with skin, causes the skin to be greasy and not have texture, is not easy to absorb, has no extensibility and can not achieve the effect of lubricating and softening the skin.

3. The invention researches the moisturizing repair face cream in the aspects of skin repair, water supplement, moisture preservation, whitening and wrinkle resistance, and the result of the pH value test is 5.2-5.6, which is suitable for the characteristics of normal human skin.

4. According to the invention, through an in-vitro moisture retention simulation experiment, the moisture retention rate can reach more than 86%; through a water replenishing and moisture preserving performance test, the water replenishing rate can reach about 160%, and the moisture preserving rate can reach about 90%; the skin irritation test result shows that the moisturizing and repairing facial cream has no irritation to healthy skin; through the tests of anti-wrinkle performance and skin repair performance, the application effect of the moisturizing repair cream in the aspects of anti-wrinkle and skin repair is superior to that of a comparative example in all the performance tests;

5. the results of high-temperature and low-temperature resistant experiments and centrifugal experiments show that the moisturizing and repairing cream has no change in properties, is easy to store and is convenient to carry.

6. The preparation method is simple in preparation process, low in equipment requirement and suitable for industrial production.

Detailed Description

The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.

Example 1

The formula is as follows: water 50.613%, caprylic/capric triglyceride 20.5%, propylene glycol 6.5%, cetearyl olive oleate 3.25%, sorbitan olive oleate 2.25%, squalane 2.2%, tocopherol acetate 2%, glycerol 7.49%, shea butter 1.5%, urea 2%, sodium hyaluronate 1%, vitamin B30.3%, acetyl chitosamine 0.2%, calcium pantothenate 0.1%, sodium citrate 0.075%, adenosine 0.01%, lactic acid 0.009%, ceramide 30.003%.

Example 2

The formula is as follows: water 45%, caprylic/capric triglyceride 21%, propylene glycol 8%, cetearyl alcohol olive oleate 5%, sorbitan olive oleate 3%, squalane 3%, tocopherol acetate 3%, glycerol 9%, shea butter 1%, urea 1%, sodium hyaluronate 0.5%, vitamin B30.1%, acetyl chitosamine 0.2%, calcium pantothenate 0.08%, sodium citrate 0.1%, adenosine 0.005%, lactic acid 0.009%, ceramide 30.006%.

Example 3

The formula is as follows: 55% of water, 20% of caprylic/capric triglyceride, 7% of propylene glycol, 4% of cetearyl olive oleate, 2% of sorbitan olive oleate, 1.5% of squalane, 1% of tocopherol acetate, 5% of glycerol, 1.2% of shea butter, 1.2% of urea, 1.3% of sodium hyaluronate, 30.5% of vitamin B, 0.1% of acetyl chitosamine, 0.08% of calcium pantothenate, 0.10% of sodium citrate, 0.008% of adenosine, 0.01% of lactic acid and 30.002% of ceramide.

Example 4

The formula is as follows: water 48.593%, caprylic/capric triglyceride 23%, propylene glycol 5%, cetearyl olive oleate 4.5%, sorbitan olive oleate 2.5%, squalane 2%, tocopherol acetate 3%, glycerol 5%, shea butter 2%, urea 3%, sodium hyaluronate 0.5%, vitamin B30.4%, acetyl chitosamine 0.3%, calcium pantothenate 0.15%, sodium citrate 0.05%, adenosine 0.007%, lactic acid 0.007%, ceramide 30.003%.

Example 5

The formula is as follows: water 53.658%, caprylic/capric triglyceride 15%, propylene glycol 6%, cetearyl alcohol olive oleate 5.5%, sorbitan olive oleate 1.5%, squalane 2.5%, tocopherol acetate 2.5%, glycerin 7%, shea butter 1.8%, urea 2.5%, sodium hyaluronate 1.5%, vitamin B30.2%, acetyl chitosamine 0.15%, calcium pantothenate 0.09%, sodium citrate 0.08%, adenosine 0.008%, lactic acid 0.013%, ceramide 30.001%.

Example 6

The formula is as follows: water 51.884%, caprylic/capric triglyceride 25%, propylene glycol 5.5%, cetearyl olive oleate 2.5%, sorbitan olive oleate 1.8%, squalane 1.5%, tocopherol acetate 1.5%, glycerol 6%, shea butter 1.5%, urea 1.5%, sodium hyaluronate 0.6%, vitamin B30.3%, acetyl chitosamine 0.25%, calcium pantothenate 0.05%, sodium citrate 0.09%, adenosine 0.015%, lactic acid 0.013%, ceramide 30.001%.

Examples 1-6 were each prepared by the methods of examples 7, 8, 9, 10, 11, 12, and 13, respectively.

Example 7

The preparation method comprises the following steps: taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 30min to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 50 ℃ for 20min, taking out, and cooling to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, heating the water to the temperature of 75 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to the room temperature to obtain a third mixture; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; mixing the first mixture, the second mixture, the third mixture and the fourth mixture, uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, and then placing the emulsion into an ultraviolet sterilization box for sterilization treatment for 200min to obtain the moisturizing and repairing facial cream.

Example 8

The preparation method comprises the following steps: taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 25min to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 40 ℃ for 15min, taking out, and cooling to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, heating the water to 60 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain a third mixture; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

Example 9

The preparation method comprises the following steps: taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 35min to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 60 ℃ for 25min, taking out, and cooling to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, heating the water to the temperature of 90 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to the room temperature to obtain a third mixture; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

Example 10

The preparation method comprises the following steps: taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 28min to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in 48 ℃ water bath for 18min, taking out, and cooling to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, heating the water to the temperature of 65 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to the room temperature to obtain a third mixture; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

Example 11

The preparation method comprises the following steps: taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 32min to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in 55 ℃ water bath for 22min, taking out, and cooling to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, heating the water to 70 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain a third mixture; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

Example 12

The preparation method comprises the following steps: putting adenosine, tocopherol acetate and propylene glycol in a glass container according to the weight percentage, and performing ultrasonic treatment for 34min to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in a water bath at 58 ℃ for 24min, taking out, and cooling to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, heating the water to the temperature of 80 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to the room temperature to obtain a third mixture; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

Example 13

The preparation method comprises the following steps: taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 33min to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 46 ℃ for 22min, taking out, and cooling to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, heating the water to 85 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain a third mixture; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

To further verify the feasibility of the present invention, the inventors performed a series of experiments, as follows:

1. an experimental instrument:

an electronic balance: model FA2-204-N, Shanghai Cyanina instruments Ltd

Digital display constant temperature water bath pot model DRRH-S4, Shanghai Shuangjie experiment equipment Co., Ltd

Heat-collecting magnetic stirrer model DF-101S, Jiangsu Ke Caesalpi Ltd

Refrigerator-freezer model BCD-118TMPA, Qingdao Haier Ltd

Electrothermal constant-temperature drying oven model HPD-101-3A, Changzhou City Huapoda teaching instruments Co., Ltd

Ultrasonic cleaner model SK8-210-HP, Shanghai Ke Shuan ultrasonic Instrument Co., Ltd

PH meter tester, model PHS-25, Shanghai apparatus, electric science apparatus, Inc

Table type electric centrifuge, model 80-2, Changzhou gold Tan Liangyou Instrument Co., Ltd

Corneometer skin moisture detector: model CM285, Meinuo electronic Tech Co Ltd

Ultraviolet sterilization box: model AR-101, Shanghai apparatus, electrosciences instruments, Inc

2. Raw materials and auxiliary materials

Caprylic/capric triglyceride: chongqing Chuandong chemical Co Ltd

Propylene glycol: chongqing Chuandong chemical Co Ltd

Cetearyl olive oleate: chongqing Chuandong chemical Co Ltd

Squalane: saen chemical technology Co., Ltd

Tocopherol acetate: chongqing Chuandong chemical Co Ltd

Glycerol: saen chemical technology Co., Ltd

Shea butter: chongqing Chuandong chemical Co Ltd

Urea: saen chemical technology Co., Ltd

Sodium hyaluronate: chongqing Chuandong chemical Co Ltd

Vitamin B3: zhejiang province Tianhong Biotechnology Co., Ltd

Acetyl chitosamine: saen chemical technology Co., Ltd

Calcium pantothenate: chongqing Chuandong chemical Co Ltd

Sodium citrate: zhejiang province Tianhong Biotechnology Co., Ltd

Adenosine: saen chemical technology Co., Ltd

Lactic acid: zhejiang province Tianhong Biotechnology Co., Ltd

Ceramide 3: saen chemical technology Co., Ltd

3. Formulation and Process screening

3.1 formulation

3.1.1 sources of formulation: according to the properties of the common raw and auxiliary materials of the cosmetics and the problems of the face cream in the prior art, the skin cream is considered to have the advantages of no toxicity, no stimulation, compatibility with human skin, good extensibility, promotion of cell metabolism, lubrication, skin softening effect, no pore blockage and no acne as the preferred components, and the combination of the raw and auxiliary materials with the effects of skin repair, water supplement, moisture preservation, whitening and wrinkle resistance as the preferred components.

Caprylic/capric triglyceride: it is a derivative of palm oil or coconut oil, it is extracted by thermal fractionation, because it has compatible characteristics with human skin, it does not block pores, it has non-greasy feeling, it can be added into cream or lotion to improve its extensibility, it has lubricating and skin softening effects, and it has the function of filtering ultraviolet light.

Cetearyl olive oleate: the main function is emulsifier, which is non-toxic, non-irritant and non-acne.

Sorbitan olive oleate ester: the product can be used as emulsifier, dispersant and emulsion stabilizer. As a conditioner, an emollient, an emulsifier, etc., and is applied to the field of personal care products. As a lubricant application.

Squalane: the skin care cream is a lipid closest to sebum of a human body, has strong affinity, can be integrated with the sebum membrane of the human body, forms a natural barrier on the surface of the skin, can strengthen the repair of the epidermis, effectively forms a natural protective film and helps the balance between the skin and the sebum. Can also inhibit the peroxidation of skin lipid, effectively permeate into the skin, promote the proliferation of skin basal cells, and has obvious physiological effects on delaying skin aging, improving and eliminating chloasma. Squalane also can open skin pores, promote blood microcirculation, promote cell metabolism, and help repair damaged cells.

Tocopherol acetate: can be used as antioxidant in vivo, and can eliminate free radicals in vivo and reduce the damage of ultraviolet rays to human body.

Shea butter: the shea butter has the effects of moisturizing and moisturizing in cosmetics, can prevent the moisture loss of skin, provides sufficient moisture for the skin, is very suitable for dry skin, and can help wound healing and increase the defense capacity of the skin.

Urea: is a good moisturizing ingredient, and urea has the effects of moisturizing and softening cutin for skin, so that the cutin can be prevented from blocking capillary pores, thereby improving the problem of acne.

Sodium hyaluronate: is extracted from rooster comb, or is prepared by fermenting with lactococcus lactis, and has moisture keeping effect.

Vitamin B3: can inhibit the transfer of melanin from melanocyte to protein cell, and reduce hyperpigmentation; accelerating skin metabolism, promoting the exfoliation of melanin-containing keratinocytes, and maintaining cell balance level to be in a young state; promoting the synthesis of epidermal layer protein, enhancing skin moisture content, and improving skin quality.

Acetyl chitosamine: resisting oxidation, and accelerating cutin renewal.

Calcium pantothenate: can promote cell formation on skin, and is helpful for wound healing; can also promote cell metabolism.

Sodium citrate: has moisturizing effect in cosmetic field.

Adenosine: is an endogenous nucleoside distributed throughout human body cells, has the function of anti-aging in cosmetics, and adenosine is used as an antioxidant, a skin conditioner and a humectant in cosmetics; adenosine is an anti-aging lead-in body, can supplement skin energy, remarkably improve the elasticity of skin, promote skin cell metabolism, prevent the relaxation of skin tissues, reorganize the skin structure and enable the skin to recover the elasticity by tightening and shrinking pores; the adenosine component is suitable for wrinkle skin, sensitive skin, oily skin, pigmented skin, dry skin, etc.

Lactic acid: the lactic acid has the main functions of removing cutin, moisturizing, whitening and removing freckles in cosmetics and skin care products, and has no side effect or acne-causing property.

Ceramide 3: ceramide is a latest generation humectant developed in recent years, has a structure similar to that of substances constituting the horny layer of the skin, can quickly permeate into the skin, and is combined with water in the horny layer to form a net structure to retain water.

3.1.2 formula design: four are preliminarily designed, and are respectively as follows:

the formula I is as follows: 45-55% of water, 15-25% of caprylic/capric triglyceride, 5-8% of propylene glycol, 2.5-5.5% of cetearyl olive oleate, 1.5-3% of sorbitan olive oleate, 1.5-3% of squalane, 1-3% of tocopherol acetate, 5-9% of glycerol, 1-2% of shea butter, 1-3% of urea, 0.5-1.5% of sodium hyaluronate, 30.1-0.5% of vitamin B, 0.1-0.3% of acetyl chitosamine, 0.05-0.15% of calcium pantothenate, 0.04-0.10% of sodium citrate, 0.005-0.015% of adenosine, 0.005-0.013% of lactic acid and 0.006% of ceramide 30.001-0.006%.

And a second formula: 45-55% of water, 8-12% of cetearyl alcohol olive oleate, 4-8% of sorbitan olive oleate, 2-8% of squalane, 5-7% of glycerol, 4-8% of shea butter, 6-10% of urea, 2-6% of sodium hyaluronate, 0.1-0.3% of vitamin B33, 0.05-0.15% of acetyl chitosamine, 0.04-0.10% of calcium pantothenate, 0.005-0.015% of sodium citrate, 0.005-0.013% of lactic acid and 30.001-0.006% of ceramide.

And the formula III: 45-55% of water, 15-25% of caprylic/capric triglyceride, 5-8% of propylene glycol, 3-5% of cetearyl olive oleate, 1.5-3% of sorbitan olive oleate, 1.5-3% of squalane, 1-3% of tocopherol acetate, 5-9% of glycerol, 4-8% of shea butter, 0.1-0.3% of acetyl chitosamine, 0.05-0.15% of calcium pantothenate, 0.005-0.015% of adenosine, and 30.001-0.006% of ceramide

The formula four: 45-55% of water, 15-25% of caprylic/capric triglyceride, 5-8% of propylene glycol, 1.5-3% of sorbitan olivate, 1.5-3% of squalane, 1-3% of tocopherol acetate, 5-9% of glycerol, 1-3% of shea butter, 1-3% of urea, 2-5% of sodium hyaluronate, 30.1-0.5% of vitamin B, 0.04-0.10% of sodium citrate, 0.005-0.015% of adenosine and 0.005-0.013% of lactic acid.

And a fifth formula: 45-55% of water, 15-25% of caprylic/capric triglyceride, 5-8% of propylene glycol, 2.5-5.5% of cetearyl olive oleate, 1.5-3% of squalane, 1-3% of tocopherol acetate, 5-9% of glycerol, 1-3% of urea, 0.5-1.5% of sodium hyaluronate, 0.1-0.3% of acetyl chitosamine, 0.05-0.15% of calcium pantothenate, 0.005-0.015% of adenosine, 0.005-0.013% of lactic acid and 30.001-0.006% of ceramide.

3.2, a preparation process:

the first process comprises the following steps: taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 25-35min to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 40-60 ℃ for 15-25min, taking out, and cooling to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, heating the water to the temperature of 60-90 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain a third mixture; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

And a second process: taking adenosine, tocopherol acetate and propylene glycol in percentage by weight, stirring and dissolving in a glass container to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, dissolving the glycerol and the calcium pantothenate completely by using water at 60 ℃, and cooling the solution to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring, and cooling to room temperature to obtain a mixture III; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

And a third process: mixing 45-55% of water, 15-25% of caprylic/capric triglyceride, 5-8% of propylene glycol, 2.5-5.5% of cetearyl alcohol olive oleate, 1.5-3% of sorbitan olive oleate, 1.5-3% of squalane, 1-3% of tocopherol acetate, 5-9% of glycerol, 1-2% of shea butter, 1-3% of urea, 0.5-1.5% of sodium hyaluronate, 30.1-0.5% of vitamin B, 0.1-0.3% of acetyl chitosamine, 0.05-0.15% of calcium pantothenate, 0.04-0.10% of sodium citrate, 0.005-0.015% of adenosine, 0.005-0.013% of lactic acid and 30.001-0.006% of ceramide by weight percentage, and uniformly stirring by using a heat collection type magnetic stirrer to obtain the moisturizing cream.

And (3) grading the face cream, wherein the prepared face cream is subjected to comprehensive grading according to the grading standard in the table 1, and the comprehensive grading is the sum of all indexes and is 10 points in full.

TABLE 1 moisturizing and repairing face cream

According to the scoring standards in the table 1, the prepared moisturizing repair cream is subjected to preliminary screening scoring in the aspects of solubility, glossiness, spreadability, centrifugation degree and the like, the scoring results are four grades of excellent (2.0-2.5), good (1.0-1.9), medium (0.4-0.9) and poor (0-0.3), and because the screening objects in the experiment are different, the scoring mode of the moisturizing repair cream has two modes of comprehensive scoring and single scoring. The comprehensive score means that the score is respectively graded from four angles of solubility, glossiness, coating and centrifugation, and the comprehensive score is the sum of all index scores and is 10 points full.

The moisturizing repair face cream produced by the formula I, the formula II, the formula III, the formula IV and the formula V and the process I, the process II and the process III respectively has the highest combined score of the formula I and the process, and is shown in a table 2.

Table 2 optimal formulation and process combination verification experimental results

As a result: from the above table, the best combination can be found as: "formulation one" and "process one" are preferred: namely, the formula one is as follows: 45-55% of water, 15-25% of caprylic/capric triglyceride, 5-8% of propylene glycol, 2.5-5.5% of cetearyl olive oleate, 1.5-3% of sorbitan olive oleate, 1.5-3% of squalane, 1-3% of tocopherol acetate, 5-9% of glycerol, 1-2% of shea butter, 1-3% of urea, 0.5-1.5% of sodium hyaluronate, 30.1-0.5% of vitamin B, 0.1-0.3% of acetyl chitosamine, 0.05-0.15% of calcium pantothenate, 0.04-0.10% of sodium citrate, 0.005-0.015% of adenosine, 0.005-0.013% of lactic acid, and 0.006% of ceramide 30.001-0.006%; the process one comprises the following steps:

taking adenosine, tocopherol acetate and propylene glycol in percentage by weight in a glass container, and carrying out ultrasonic treatment for 25-35min to obtain a first mixture; putting glycerol and calcium pantothenate in percentage by weight into a glass container, heating in water bath at 40-60 ℃ for 15-25min, taking out, and cooling to room temperature to obtain a second mixture; putting water in a glass container according to the weight percentage, heating the water to the temperature of 60-90 ℃, then respectively adding urea, sodium hyaluronate, vitamin B3, sodium citrate and lactic acid according to the weight percentage, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain a third mixture; uniformly stirring caprylic/capric triglyceride, cetearyl alcohol olive oleate, sorbitan olive oleate, squalane, shea butter, acetyl chitosamine and ceramide 3 in percentage by weight to obtain a mixture IV; and mixing the first mixture, the second mixture, the third mixture and the fourth mixture, and uniformly stirring by using a heat collection type magnetic stirrer until uniform emulsion is formed, namely the moisturizing and repairing cream.

4. Quality evaluation experiment of the invention

The products prepared in example 1 and example 7, example 2 and example 8, and example 3 and example 9 were taken in parallel, each 3 parts, each 100mL, to make a quality evaluation experiment mother liquor.

4.1 appearance Properties and fineness

5g of each of the products prepared in examples 1 and 7, 2 and 8, and 3 and 9 was placed in a 10mL test tube and observed for appearance; coating a proper amount of the finished product on the back of the hand, and evaluating the fineness of the hand through sensory indexes.

And (4) checking results: the product is white semitransparent jelly, is uniform, fine, glossy, smooth in touch and moderate in viscosity;

4.2 pH value

2.5g of each of the products prepared in examples 1 and 7, 2 and 8, and 3 and 9 was dissolved in 50mL of distilled water, and the solution was cooled to room temperature for 30min at 40 ℃ and then the pH was measured.

As a result: the product prepared in example 1 and example 7, pH 5.5; the pH of the product prepared in examples 2 and 8 was 5.2, and the pH of the product prepared in examples 3 and 9 was 5.3. The pH value of the skin is optimal between pH5.0 and 5.6, and the pH results of 3 finished products are in the range.

4.3 simulation experiment for in vitro moisture retention

In order to better simulate human skin, a layer of 3M medical breathable adhesive tape is selected to be used for manufacturing a simulation device in the experiment. In the experiment, the temperature was maintained at room temperature, and the products of examples 1 and 7, examples 2 and 8, and examples 3 and 9, and comparative example 1(CN201811493943.7), comparative example 2(CN202010294716.2), each 0.5g of which was weighed out and applied to the surface of a simulation device, were left at room temperature for 12 hours, and then weighed out to calculate the moisture retention rate.

The moisture retention rate (100%) -3M adhesive plaster weight of the sample after standing for 12 h/mass of the sample before standing × 100%

TABLE 3 in vitro moisturizing test results

As a result: table 3 shows that the moisturizing repair creams prepared from the products prepared in examples 1 and 7, examples 2 and 8, and examples 3 and 9 of the present invention have excellent moisturizing properties and are superior to the comparative list. See table 3.

4.4 centrifugation experiments

At room temperature, 50g of the product of example 1 and example 7, example 2 and example 8, and example 3 and example 9 was put into a 100mL centrifuge tube, and the tube was placed in a centrifuge and rotated at 1000, 2000, 3000, 4000, 5000rpm for 10min, and the presence or absence of water in the sample was observed.

As a result: no delamination occurred.

4.5 skin irritation test

In parallel, three portions (proper amount) of the products of example 1 and example 7, example 2 and example 8, and example 3 and example 9 are respectively coated on the inner skin of the left wrist of a healthy human body, the three portions are coated in three times, the coating is kept for 24 hours once, and the three portions are observed by eyes after 24 hours.

As a result: no adverse phenomenon was generated in each sample for three times, and it was preliminarily confirmed that the cream was not irritant to healthy skin.

4.6 moisturizing Performance test

30 female volunteers between 18-50 ages were found and divided into 3 groups of 10 persons, and the products prepared in examples 1 and 7, 2 and 8, 3 and 9 and comparative examples 1(CN201811493943.7) and 2(CN202010294716.2) were used. In an indoor environment at 20 ℃ and 50% relative humidity, a fixed area of 2 square centimeters is drawn on the forehead of each volunteer, and after the skin-testing product is used in the fixed area, the skin humidity change data is comprehensively obtained by testing with a Corneometer CM285 skin moisture detector, and the test results are shown in the following table 4 (each value is an average value of 10 volunteers in the group):

table 4 moisturizing performance test result recording table

4.7 wrinkle resistance test

30 female volunteers between 35 and 50 ages were found and divided into six groups of 5 persons, wherein three groups of the female volunteers respectively used the products prepared in example 1 and example 7, example 2 and example 8, and example 3 and example 9, and the products of comparative example 1(CN201811493943.7), comparative example 2(CN202010294716.2) and the commercial cream, and the corresponding products were respectively smeared at the canthus and forehead wrinkles of each volunteer, and the results are shown in Table 5.

TABLE 5 anti-wrinkle Performance test results Table

4.8 skin repair Performance test

Female volunteers 30 between the ages of 25 and 50 were identified in six groups of 5 persons, wherein three groups were respectively the product of ratio 1(CN201811493943.7) and comparative example 2(CN202010294716.2), and the corresponding product was applied to the canthus and forehead wrinkles of each volunteer using the products prepared in example 1 and example 7, example 2 and example 8, example 3 and example 9, the commercial cream and the product, respectively, and the results are shown in Table 6.

Table 6 skin repair performance test result recording table

4.9 high temperature and Low temperature test

50g of each of the products of example 1 and example 7, example 2 and example 8, and example 3 and example 9 was put into a centrifuge tube, placed in a 100 ℃ constant temperature water bath and a-5 ℃ and-10 ℃ refrigerator, kept for 24h, returned to room temperature and observed to see whether there was a significant difference from the previous experiment.

As a result: the moisturizing and repairing face cream has no change of characters.

5. Conclusion of the research experiment

The research and development explores the moisturizing and repairing face cream in the aspects of skin repairing, moisturizing, whitening and wrinkle resisting, and the result is 5.2-5.6 through the pH value test, so that the moisturizing and repairing face cream is suitable for the characteristics of normal human skin; through an in-vitro moisture retention simulation experiment, the moisture retention rate can reach over 86 percent and is superior to that of a comparative example; through a water replenishing and moisture preserving performance test, the water replenishing rate can reach about 160 percent, the moisture preserving rate can reach about 90 percent, and the water replenishing and moisture preserving performance test is superior to a comparative example; the skin irritation test result shows that the moisturizing and repairing facial cream has no irritation to healthy skin; through the tests of anti-wrinkle performance and skin repair performance, the moisturizing repair cream has a large application effect in the aspects of anti-wrinkle and skin repair; through high-temperature and low-temperature resistant experiments and centrifugal experiments, the results show that the moisturizing and repairing cream has no change in properties, is easy to store and is convenient to carry; the preparation method has simple process and low requirement on equipment, and is suitable for industrial production.

Although the invention has been described in detail hereinabove by way of general description, specific embodiments and experiments, it will be apparent to those skilled in the art that modifications and improvements can be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.