阅读说明：本技术 生物电信号采集与电刺激装置 (Bioelectric signal acquisition and electrical stimulation device ) 是由 李志宏 李君实 黄东 于 2020-11-24 设计创作，主要内容包括：本发明提供一种生物电信号采集与电刺激装置,所述生物电信号采集与电刺激装置包括：衬底,所述衬底具有用于贴合于目标的工作侧面；多个探头,多个所述探头均设于所述衬底,且在所述工作侧面上阵列排布；多个导电引线,多个所述导电引线与多个所述探头一一对应电连接；输入/输出端口,多个所述导电引线均与所述输入/输出端口电连接。本发明提供的生物电信号采集与电刺激装置,通过在衬底上设置多个探头,并通过多个导电引线将探头的电信号引出,能够在多个点位实现对目标的生物电信号采集和电刺激,适于高密度体表电信号采集与电刺激,能够提高采集与电刺激的效率和准确率。(The invention provides a bioelectric signal acquisition and electrical stimulation device, which comprises: a substrate having a working side for conforming to a target; the probes are arranged on the substrate and are arranged on the working side surface in an array manner; the plurality of conductive leads are electrically connected with the plurality of probes in a one-to-one correspondence manner; and the input/output port is electrically connected with the plurality of conductive leads. According to the bioelectricity signal acquisition and electrical stimulation device provided by the invention, the plurality of probes are arranged on the substrate, and the electric signals of the probes are led out through the plurality of conductive leads, so that the acquisition and electrical stimulation of target bioelectricity signals can be realized at a plurality of point positions, the bioelectricity signal acquisition and electrical stimulation device is suitable for high-density body surface electric signal acquisition and electrical stimulation, and the efficiency and accuracy of acquisition and electrical stimulation can be improved.)

1. A bioelectrical signal collection and stimulation device, comprising:

a substrate having a working side for conforming to a target;

the probes are arranged on the substrate and are arranged on the working side surface in an array manner;

the plurality of conductive leads are electrically connected with the plurality of probes in a one-to-one correspondence manner;

and the input/output port is electrically connected with the plurality of conductive leads.

2. The bioelectrical signal acquisition and stimulation device according to claim 1, wherein the probe comprises:

a plurality of microneedles, each of the plurality of microneedles electrically connected to the conductive leads.

3. The bioelectrical signal acquisition and stimulation device according to claim 2, wherein a plurality of the microneedles are connected to the substrate.

4. The bioelectrical signal acquiring and stimulating device according to claim 2, wherein the plurality of microneedles are arranged in a circular array, a square array or an elliptical array.

5. The bioelectrical signal acquisition and stimulation device according to claim 2, wherein the probe further comprises:

the base, the base install in the substrate, the micropin is located the base, the micropin pass through the base with electrically conductive lead wire electricity is connected.

6. The bioelectric signal acquisition and stimulation device according to claim 2, characterized by further comprising:

the insulating layer covers the working side face, and the probe extends out of the insulating layer.

7. The bioelectrical signal acquisition and stimulation device according to claim 2, wherein the microneedle has a length of 100 μm to 1000 μm;

alternatively, the diameter of the microneedle is 50 μm to 300 μm;

alternatively, the distance between adjacent microneedles is 100 μm to 1000 μm.

8. The bioelectric signal acquisition and stimulation device according to any one of claims 1 to 7, characterized by further comprising:

the bond is connected with the substrate, the bond is connected with the input/output port, and the conductive lead is arranged in the bond and extends from the bond to be electrically connected with the input/output port.

9. The bioelectrical signal acquisition and stimulation device according to any one of claims 1 to 7, wherein the thickness of the substrate is 10 μm to 500 μm;

or the distance between the adjacent probes is 1mm-10 mm.

10. The bioelectrical signal acquisition and stimulation device according to any one of claims 1 to 7, wherein the substrate is a flexible substrate.

Technical Field

The invention relates to the technical field of wearable equipment, in particular to a bioelectricity signal acquisition and electrical stimulation device.

Background

The body surface bioelectric signals can reflect various physiological, psychological and pathological information of organisms, so that the acquisition of the body surface bioelectric signals has important clinical significance. The electrical stimulation is implemented on the body surface, and medical and man-machine interaction scenes such as nerve function regulation, touch simulation and the like can be realized. The non-implanted body surface electrode is the best choice for most clinical and research scenes due to the characteristics of safety and convenience. Body surface electrophysiological signals represented by brain waves (EEG) are generally weak in amplitude, and therefore a low contact impedance between electrodes and skin is required to achieve a high signal-to-noise ratio.

At present, the widely used body surface electrode is the wet electrode, the wet electrode realizes low impedance contact with the help of the conductive adhesive layer smeared between the metal electrode and the skin, however, with the progress of the brain-computer interface technology, higher and higher requirements are provided for the space resolution of bioelectricity signal acquisition and electrical stimulation, a high-density system is needed to realize the bioelectricity signal acquisition and electrical stimulation, if the wet electrode is used in the high-density system, the conductive adhesive needs to be repeatedly added to a large number of electrodes, the working efficiency is lower, and the conductive adhesive is easy to generate short circuit between the electrodes close to each other, so that the identification is inaccurate.

Disclosure of Invention

The invention provides a bioelectricity signal acquisition and electrical stimulation device, which is used for solving the defects that in the prior art, conductive adhesive needs to be repeatedly added to a large number of electrodes when wet electrodes are used in a high-density system, the working efficiency is low, short circuit is easy to occur between the electrodes close to each other by the conductive adhesive, and the identification is inaccurate, realizing the acquisition and electrical stimulation of bioelectricity signals of a target at a plurality of points, being suitable for the acquisition and electrical stimulation of high-density body surface electric signals, and improving the efficiency and accuracy of the acquisition and electrical stimulation.

The invention provides a bioelectric signal acquisition and electrical stimulation device, which comprises: a substrate having a working side for conforming to a target; the probes are arranged on the substrate and are arranged on the working side surface in an array manner; the plurality of conductive leads are electrically connected with the plurality of probes in a one-to-one correspondence manner; and the input/output port is electrically connected with the plurality of conductive leads.

According to the bioelectric signal acquisition and electrical stimulation device provided by the invention, the probe comprises: a plurality of microneedles, each of the plurality of microneedles electrically connected to the conductive leads.

According to the bioelectrical signal acquisition and electrical stimulation device provided by the invention, the microneedles are connected with the substrate.

According to the bioelectrical signal acquisition and electrical stimulation device provided by the invention, the microneedles are arranged in a circular array, a square array or an elliptical array.

According to the bioelectric signal acquisition and electrical stimulation device provided by the invention, the probe further comprises: the base, the base install in the substrate, the micropin is located the base, the micropin pass through the base with electrically conductive lead wire electricity is connected.

According to the bioelectric signal acquisition and electrical stimulation device provided by the invention, the bioelectric signal acquisition and electrical stimulation device further comprises: the insulating layer covers the working side face, and the probe extends out of the insulating layer.

According to the bioelectrical signal acquisition and electrical stimulation device provided by the invention, the length of the microneedle is 100-1000 μm; alternatively, the diameter of the microneedle is 50 μm to 300 μm; alternatively, the distance between adjacent microneedles is 100 μm to 1000 μm.

According to the bioelectric signal acquisition and electrical stimulation device provided by the invention, the bioelectric signal acquisition and electrical stimulation device further comprises: the bond is connected with the substrate, the bond is connected with the input/output port, and the conductive lead is arranged in the bond and extends from the bond to be electrically connected with the input/output port.

According to the bioelectric signal acquisition and electrical stimulation device provided by the invention, the thickness of the substrate is 10-500 μm; or the distance between the adjacent probes is 1mm-10 mm.

According to the bioelectrical signal acquisition and electrical stimulation device provided by the invention, the substrate is a flexible substrate.

According to the bioelectricity signal acquisition and electrical stimulation device provided by the invention, the plurality of probes are arranged on the substrate, and the electric signals of the probes are led out through the plurality of conductive leads, so that the acquisition and electrical stimulation of target bioelectricity signals can be realized at a plurality of point positions, the bioelectricity signal acquisition and electrical stimulation device is suitable for high-density body surface electric signal acquisition and electrical stimulation, and the acquisition and electrical stimulation efficiency and accuracy can be improved.

Drawings

In order to more clearly illustrate the technical solutions of the present invention or the prior art, the drawings needed for the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and those skilled in the art can also obtain other drawings according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram of a bioelectrical signal collecting and electrical stimulating apparatus provided in the present invention;

FIG. 2 is a schematic view of a partial structure of the bioelectrical signal collecting and electrical stimulating apparatus provided in the present invention;

FIG. 3 is one of the side cross-sectional views of the bioelectrical signal acquisition and stimulation device provided by the present invention;

FIG. 4 is a second schematic view of a partial structure of the bioelectrical signal collecting and electro-stimulating device according to the present invention;

FIG. 5 is a second side sectional view of the bioelectrical signal collecting and electro-stimulating device provided in the present invention;

FIG. 6 is a second schematic structural view of the bioelectrical signal collecting and electrical stimulating apparatus provided in the present invention;

FIG. 7 is a third schematic structural view of the bioelectrical signal collecting and electrical stimulating apparatus according to the present invention;

fig. 8 is a fourth schematic structural view of the bioelectric signal collecting and electrical stimulating device provided by the present invention.

Reference numerals:

10: a substrate; 11: a working side surface; 20: a probe;

21: microneedles; 22: a base; 30: a conductive lead;

40: an input/output port; 50: an insulating layer; 60: and (4) banding.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the embodiments of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top", "bottom", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, which are only used for convenience in describing the embodiments of the present invention and simplifying the description, but do not indicate or imply that the referred devices or elements must have specific orientations, be constructed in specific orientations, and be operated, and thus, should not be construed as limiting the embodiments of the present invention.

In the description of the embodiments of the present invention, it should be noted that, unless explicitly stated or limited otherwise, the terms "connected" and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. Specific meanings of the above terms in the embodiments of the present invention can be understood in specific cases by those of ordinary skill in the art.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of an embodiment of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.

The bioelectric signal collecting and electro-stimulating apparatus of the present invention will be described with reference to fig. 1 to 8.

As shown in fig. 1, an embodiment of the present invention provides a bioelectrical signal collecting and electrically stimulating device, including: a substrate 10, a plurality of probes 20, a plurality of conductive leads 30, and an input/output port 40.

Wherein the substrate 10 has a working side 11 for attaching to a target.

It is understood that the substrate 10 may be a sheet structure, and can be attached to a target, and the target may be various organisms, such as a human body, or other animal bodies, such as some domestic animals or pets, and can monitor the body surface electrical signals of these organisms to assist in determining the health status, and the body surface electrical signals can reflect various physiological, psychological and pathological information, and have important clinical significance. And the target organism can be electrically stimulated on the body surface, and medical and man-machine interaction scenes such as nerve function regulation, touch simulation and the like can be realized.

For example, the substrate 10 may be attached to the skin of the head of a human body for monitoring brain waves or applying electrical stimulation to the brain region, and may be used for human-computer interaction.

The substrate 10 may be made of a flexible material. The substrate 10 using a flexible material can be adapted to the shape of the skin surface of the subject, can be attached well to almost any skin surface, and reduces the discomfort given to the subject.

The thickness of the substrate 10 may be 10 μm-500 μm, such as 200 μm.

The substrate 10 has a working side 11, the working side 11 is in contact with an object, and the working side 11 can have viscosity, so that stable adhesion and fixation in a detection process are realized, and the flexibility of the substrate 10 is ensured.

A plurality of probes 20 are each provided on the substrate 10 and are arranged in an array on the working side 11.

It will be appreciated that the probe 20 is mounted on the working side 11 of the substrate 10, and that when the working side 11 is bonded to a target, the probe 20 is capable of contacting the target, penetrating the high impedance stratum corneum, providing low impedance and stable electrical contact without conductive glue, and being wearable by a user for extended periods of time due to the absence of conductive paste, improving the applicability of various applications.

The probes 20 are arranged in an array on the working side surface 11, for example, a 6 × 6 square matrix or an 8 × 8 square matrix, or other types of array arrangement manners, the conductive leads 30 are electrically connected with the probes 20 in a one-to-one correspondence manner, that is, each probe 20 has one conductive lead 30 to derive the identified electrical signal, so that electrical signals at multiple positions of a target can be read, or electrical stimulation is applied to multiple positions of the target respectively, the method and the device are suitable for a high-density acquisition and electrical stimulation system, and the spatial resolution of acquisition and electrical stimulation of bioelectric signals can be improved.

The plurality of conductive leads 30 are electrically connected to the input/output port 40, the plurality of conductive leads 30 lead the electrical signals of the corresponding probes 20 to the input/output port 40, the input/output port 40 can be electrically connected to an external device, the input/output port 40 transmits multiple electrical signals, and the electrical signals recognized by different probes 20 are output to the external device or received from the external device. Thus, the external device can recognize the electric signals of different positions of the target, recognize corresponding physiological information through the electric signals of different positions, or input electric stimulation to different positions. For example, brain waves of different meanings can be recognized according to electric signals of different positions of the head.

The distance between the adjacent probes 20 may be 1mm-10mm, for example, 5mm, and the smaller distance between the adjacent probes 20 can further improve the spatial resolution of the electrical signal acquisition and electrical stimulation of the target position.

At present, the widely used body surface electrodes are mainly wet electrodes, and reliable and low-resistance contact is realized by means of a conductive adhesive layer coated between a metal electrode and the skin. With the recent progress of brain-computer interface technology, higher and higher requirements are put on the spatial resolution of the acquisition of biological surface electrical signals (especially electroencephalogram and myoelectric signals) and the electrical stimulation, so as to decode more precise instructions or intentions from signals of more channels.

The conductive paste used in wet electrodes gradually degrades over time and loses conductivity, and for high density systems it is impractical to repeatedly add conductive paste to a large number of electrodes multiple times during use. Meanwhile, the high-density acquisition and electrical stimulation electrode has millimeter-scale spatial resolution, and the conductive adhesive is easy to generate 'bridging' short circuit between electrodes which are too close to each other.

The inventor finds in research that a more optimal solution for a reliable high-density body surface electrical signal acquisition and electrical stimulation system is to use dry electrodes, i.e. metal electrodes that are in direct contact with the skin without conductive gel. In current consumer-level body surface electric signal acquisition equipment, only rigid planar electrodes are usually adopted, and the contact performance with the skin is poor, so that the signal quality is seriously influenced. In order to improve the performance of dry electrodes, new dry electrodes based on flexible, stretchable or porous materials can be used to enhance the fit of the electrode to the skin and to increase the contact area as much as possible, but the excessive area of such electrodes prevents them from developing to higher densities and the impedance characteristics are not significantly advantageous over wet electrodes.

The probe 20 array has great significance for convenient, stable and high-performance high-density body surface electric signal acquisition and electrical stimulation, and can obviously improve the signal quality, the spatial resolution and the wearing comfort of the system.

According to the bioelectric signal acquisition and electrical stimulation device provided by the embodiment of the invention, the plurality of probes 20 are arranged on the substrate 10, and the electrical signals of the probes 20 are led out through the plurality of conductive leads 30, so that the acquisition and electrical stimulation of target bioelectric signals can be realized at a plurality of point positions, the device is suitable for high-density body surface electrical signal acquisition and electrical stimulation, and the efficiency and accuracy of acquisition and electrical stimulation can be improved.

As shown in fig. 2, 3, 4 and 5, in some embodiments, the probe 20 includes: a plurality of microneedles 21, each microneedle 21 being electrically connected to a conductive lead 30.

It will be appreciated that each probe 20 may have a plurality of microneedles 21 thereon, and that in use, the microneedles 21 are in contact with the skin of the target and are capable of detecting an electrical signal from or applying an electrical stimulus to the target.

The microneedles 21 have good electrical conductivity, and may be made of a metal material, such as titanium, nickel, gold, platinum, or stainless steel, with good biocompatibility, or an insulating substrate with a surface plated with a metal material, and have good mechanical properties.

Electrode-skin contact impedance is a key factor affecting bioelectrical signal acquisition and electrical stimulation, and high electrode-skin impedance causes attenuation of the electric signal, in other words, low electrode-skin impedance is a necessary prerequisite for obtaining high quality electric signals.

In a traditional bioelectrical signal research system, there is a certain limitation in acquiring signals by using a wet electrode or a traditional dry electrode. Before the wet electrode is used, skin preparation and conductive adhesive application are needed, the skin preparation is time-consuming and inconvenient, and the application of the conductive adhesive is easy to stimulate the skin and cause allergy. Some conventional dry electrodes have high impedance and need to be equipped with on-site high impedance amplifiers. Other conventional dry electrodes, particularly rigid electrodes, do not fully conform to rough skin surfaces and have poor skin contact. Therefore, the electrode-skin impedance of the traditional dry electrode is high, the monitored bioelectric signals are not accurate enough, and the transmitted electric stimulation signals are not stable enough.

The microneedles 21 have a length of 100 μm to 1000 μm, and may be 500 μm, for example.

In order to ensure that the microneedles 21 can smoothly penetrate through the stratum corneum and cause no bleeding or severe pain, the length of the microneedles 21 is particularly critical, and according to the skin structure, the length of the microneedles 21 is theoretically more appropriate to be 100-1000 μm, so that bleeding points on the skin are avoided while smooth transmission of electric signals is ensured, and severe stabbing pain is avoided.

The micro-needle 21 can penetrate the conductive epidermis layer directly through the stratum corneum with high impedance characteristic without using conductive glue or polishing the skin by using the micro-needle 2122, so as to reduce the impedance of the electrode and the skin, and the micro-needle 21 has a smaller size, the diameter of the micro-needle 21 can be 50 μm to 300 μm, such as 200 μm, the distance between the adjacent micro-needles 21 can be 100 μm to 1000 μm, such as 500 μm, the required skin surface area is small when in use, and the medical injury brought to the user is small.

In some embodiments, the microneedle 21 is plural, and the plural microneedles 21 may be arranged in an array, as shown in fig. 1, 6, 7 and 8, and the plural microneedles 21 may be arranged in a circular array, a square array or an elliptical array. Through setting up a plurality of micropins 21 that present the array and arrange, can increase the area of contact of micropins and electrically conductive epidermal layer, and avoid single micropin 21 to break down or the error, improve sensitivity.

When the plurality of microneedles 21 are arranged in a square array, the side length of the square array may be 1mm to 10mm, for example, may be 5 mm.

As shown in fig. 4 and 5, in some embodiments, each probe 20 has a plurality of microneedles 21, and the plurality of microneedles 21 are connected to the substrate 10. it will be understood that the microneedles 21 are fabricated directly on the substrate 10, and the electrical connection is made between the conductive leads 30 and the plurality of microneedles 21, for example, the access segment of the conductive leads 30 may be mounted on the working side 11 of the substrate 10, and the plurality of microneedles 21 are electrically connected to the access segment.

As shown in fig. 2 and 3, in some embodiments, the probe 20 further comprises: a base 22.

The base 22 is attached to the substrate 10, the microneedles 21 are provided on the base 22, and the microneedles 21 are electrically connected to the conductive leads 30 through the base 22.

It can be understood that base 22 is installed on substrate 10, base 22 can be made for conducting material, base 22 can be all electrically conductive for whole, a plurality of micropins 21 are located on base 22, then the signal of telecommunication that a plurality of micropins 21 obtained all assembles on base 22, the signal of telecommunication of whole base 22 transmission is a whole, through setting up solitary base 22, can be convenient for carry out the independent processing to substrate 10 and probe 20, can improve the fashioned efficiency of parts machining, and the convenience is changed probe 20 when probe 20 breaks down.

As shown in fig. 3 and 5, in some embodiments, the bioelectrical signal collecting and electrically stimulating device further comprises: an insulating layer 50.

The insulating layer 50 covers the working side surface 11, and the probe 20 extends outward from the insulating layer 50.

It can be understood that the insulating layer 50 covers the working side 11, and only a plurality of openings are left, so that the probe 20 can extend out from the openings, and the conductive leads 30 are disposed between the insulating layer 50 and the substrate 10, so as to avoid the conductive leads 30 from directly contacting the skin to cause erroneous collection or erroneous stimulation.

As shown in fig. 7 and 8, in some embodiments, the bioelectrical signal collecting and electrically stimulating device further comprises: a ligament 60.

The ligament 60 is connected to the substrate 10, the ligament 60 is connected to the input/output port 40, and the conductive lead 30 is disposed in the ligament 60 and extends from the ligament 60 to electrically connect to the input/output port 40.

It is understood that the ligament 60 may be a long strip, the output interface is connected to the substrate 10 through the ligament 60, the conductive lead 30 is disposed on the ligament 60, for example, the conductive lead may be embedded inside the ligament 60, or a flat cable may be formed on the ligament 60, and the probe 20 may be connected to the remote input/output port 40 through the ligament 60, so that the activity of the target organism may be less affected during the electrical signal monitoring and electrical stimulation.

The above-described embodiments of the apparatus are merely illustrative, and the units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of the present embodiment. One of ordinary skill in the art can understand and implement it without inventive effort.

Through the above description of the embodiments, those skilled in the art will clearly understand that each embodiment can be implemented by software plus a necessary general hardware platform, and certainly can also be implemented by hardware. With this understanding in mind, the above-described technical solutions may be embodied in the form of a software product, which can be stored in a computer-readable storage medium such as ROM/RAM, magnetic disk, optical disk, etc., and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute the methods described in the embodiments or some parts of the embodiments.

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.