阅读说明：本技术 用于pet检测器的方法和系统 (Method and system for a PET detector ) 是由 金昌良 于 2020-09-17 设计创作，主要内容包括：本发明提供了用于成像系统的检测器组件中的信号处理的方法和系统。在一个实施方案中,成像系统可以包括多个检测器块,每个检测器块包括被划分成至少两个区域的硅光电倍增器(SiPM)设备阵列,其中两个或更多个区域中的SiPM设备将信号传输到两个或更多个不同定时拾取电路。这样,SiPM阵列可以被细分成多个区域,其中来自单个区域的SiPM的求和的信号被传输到单独的定时拾取电路。(The present invention provides a method and system for signal processing in a detector assembly of an imaging system. In one embodiment, an imaging system may include a plurality of detector blocks, each detector block including an array of silicon photomultiplier (SiPM) devices divided into at least two regions, wherein the SiPM devices in two or more regions transmit signals to two or more different timing pickup circuits. In this way, the SiPM array may be subdivided into multiple zones, with the summed signals from the sipms of a single zone being transmitted to separate timing pick-up circuits.)

1. An imaging system, comprising:

one or more detector blocks, each detector block comprising an array of silicon photomultiplier (SiPM) devices divided into two or more regions, wherein the SiPM devices in the two or more regions transmit signals to two or more different timing pick-up circuits.

2. The system of claim 1, wherein the one or more detector blocks constitute a detector ring assembly of the imaging system.

3. The system of claim 1, wherein each of the two or more zones in the array of SiPM devices comprises at least one SiPM device.

4. The system of claim 3, wherein the at least one SiPM device is included in one of the two or more zones, each of the two or more zones being mutually exclusive.

5. The system of claim 3, wherein the at least one SiPM device is included in two of the two or more zones, the two of the two or more zones overlapping each other.

6. The system of claim 1, wherein each of the two or more regions transmits a signal to one of the two or more different timing pick-up circuits via an output array.

7. The system of claim 6, wherein the output array comprises a plurality of output channels.

8. The system of claim 7, wherein a number of output channels in the output array is equal to a number of SiPM devices in an area coupled to the output array, wherein each SiPM device maps to an output channel in the output array.

9. The system of claim 7, wherein transmitting the signal to the one of the two or more different timing pick-up circuits via the output array comprises each output channel receiving an analog signal from a SiPM device, and the output array summing each analog signal from each output channel in the output array to generate an input signal for a timing pick-up circuit coupled to the output array, the analog signal being generated upon a photon colliding with the SiPM device.

10. The system of claim 9, wherein each of the two or more different timing pick-up circuits comprises a summing amplifier, a capacitor, and a comparator connected in series, each timing pick-up circuit comparing the input signal to a threshold signal and generating a square pulse signal in response to the input signal being above the threshold signal.

11. The system of claim 9, wherein each timing pick circuit output of the two or more different timing pick circuits is coupled to a logic circuit.

12. The system of claim 11, wherein the logic circuit receives square pulse signals from the two or more timing pickoff circuits and transmits the square pulse signal that arrives first at the logic circuit to a time-to-digital converter.

13. A method for an imaging system, comprising:

transmitting, via a first output array, a first signal generated at a silicon photomultiplier (SiPM) device included in a first area of an array of SiPM devices to a first timing pick-up circuit;

generating, at the first timing pickoff circuit, a first hit signal corresponding to the first region of the array of SiPM devices;

transmitting a second signal generated at the SiPM devices included in a second area of the array of SiPM devices to a second timing pick-up circuit via a second output array;

generating, at the second timing pick-up circuit, a second hit signal corresponding to the second region of the SiPM device array; and

transmitting one of the first hit signal and the second hit signal to reduce a dark count via a logic circuit coupled to each of the first and second timed pick circuits.

14. The method of claim 13, wherein the first signals generated at the SiPM devices in the first area are summed at the first output array and first input signals from the first output array are transmitted to the first timing pick-up circuit, and the second signals generated at the SiPM devices in the second area are summed at the second output array and second input signals from the second output array are transmitted to the second timing pick-up circuit.

15. The method of claim 13, wherein the first region of the array of SiPM devices comprises a first plurality of SiPM devices, wherein each SiPM device of the first plurality of SiPM devices is coupled to a different output channel in the first output array, and wherein the second region of the array of SiPM devices comprises a second plurality of SiPM devices, wherein each SiPM device of the second plurality of SiPM devices is coupled to a different output channel in the second output array.

16. The method of claim 13, wherein the first region of the array of SiPM devices overlaps the second region of the array of SiPM devices, wherein one or more SiPM devices are shared between the first region and the second region.

17. The method of claim 13, wherein the array of SiPM devices constitutes a single detector block in a detector ring assembly of the imaging system.

18. An imaging system, comprising:

a detector ring comprising a plurality of detector tiles; each detector block located in the plurality of detector blocks, the each detector block comprising an array of silicon photomultiplier (SiPM) devices divided into two or more regions, wherein each region comprises at least one SiPM device; and

two or more timing pickup circuits, each of the two or more timing pickup circuits coupled to one of the two or more regions via a different output array.

19. The system of claim 18, wherein the two or more timing pick-off circuits transmit respective signals from the two or more regions of the array to a single logic circuit.

20. The system of claim 18, wherein the two or more zones comprise at least one common SiPM device coupled to at least two timing pick-up circuits.

Technical Field

Embodiments of the subject matter disclosed herein relate to non-invasive diagnostic imaging, and more particularly to signal processing in Positron Emission Tomography (PET) detectors.

Background

Positron Emission Tomography (PET) scanners generate images that represent the distribution of positron emitting nuclei within a patient. When a positron interacts with an electron through annihilation, the entire mass of the electron-positive pair is converted into two photons (also called an event). Photons are emitted in opposite directions along a line of response (LOR). Annihilation photons are detected by detectors placed on both sides of the LOR in a configuration such as a ring of detectors. In time-of-flight (TOF) PET, in addition to measuring the distance and attenuation of photons, the actual time difference between the detection of photons released during a coincidence event is also measured to more accurately identify the distance from the annihilation event to the detector. The detector converts the incident photons into usable electrical signals that can be used for image formation. Thus, an image generated based on the acquired image data includes annihilation photon detection information.

Modern PET scanners include detectors, such as silicon photomultiplier (SiPM) devices, where the detectors are typically tuned so that data collection is normalized for the energy events being detected. TOF PET detectors including analog Application Specific Integrated Chips (ASICs) are expected to exhibit Coincidence Timing Resolutions (CTRs) below 200 ps. In one example, an ASIC may include a one-to-one coupling between a single crystal and an SiPM device (also referred to herein as an SiPM). To account for compton scattering between crystals in the detector, the input signals from the SiPM array may be combined into one timing channel. The response of a photon detector in the absence of light is called a dark count. In sipms, thermionic emission of electrons is a major source of dark counts. During the combining of the input signals from the SiPM array, the dark counts from the sipms are also summed. In order to keep the CTR within a certain range, it is desirable to reduce the influence of dark counts on the CTR.

Disclosure of Invention

In one embodiment, an imaging system includes one or more detector blocks, each detector block including an array of silicon photomultiplier (SiPM) devices divided into two or more regions, wherein the SiPM devices in the two or more regions transmit signals to two or more different timing pickup circuits. In this way, by dividing the SiPM array into regions where each region corresponds to a separate timing pickup circuit, the adverse effect of dark counts on a single timing pickup circuit can be reduced.

It should be appreciated that the brief description above is provided to introduce in simplified form a selection of concepts that are further described in the detailed description. It is not meant to identify key or essential features of the claimed subject matter, the scope of which is defined uniquely by the claims that follow the detailed description. Furthermore, the claimed subject matter is not limited to implementations that solve any disadvantages noted above or in any part of this disclosure.

Drawings

The invention will be better understood by reading the following description of non-limiting embodiments with reference to the attached drawings, in which:

fig. 1 is a pictorial view of an exemplary multi-modality imaging system, according to an embodiment of the invention.

Fig. 2 is a block schematic diagram of an exemplary imaging system having a detector in accordance with an embodiment of the present invention.

FIG. 3 is a schematic block diagram of a silicon photomultiplier (SiPM) array according to an embodiment of the present invention.

Fig. 4 shows a first example of dividing the SiPM array into a plurality of zones, where each zone corresponds to a separate timing pick-up circuit.

Fig. 5 shows a second example of dividing the SiPM array into a plurality of overlapping regions, where each region corresponds to a separate timing pick-up circuit.

Fig. 6 shows a third example of dividing the SiPM array into a plurality of overlapping regions, where each region corresponds to a separate timing pick-up circuit.

Fig. 7 shows a schematic diagram of a timing pick-up circuit.

Fig. 8 is a high-level flow diagram illustrating an example method for processing signals from an SiPM array.

Detailed Description

The following description relates to various embodiments of a medical imaging system. In particular, methods and systems for processing signals from a silicon photomultiplier (SiPM) array of detectors are provided. An example of a Positron Emission Tomography (PET) imaging system including a detector that may be used to detect energy events in accordance with the present technique is provided in fig. 1-2. An example SiPM array constituting a detector block is shown in fig. 3. The SiPM array may be divided into a plurality of zones, with each zone corresponding to a separate timing pick-up circuit. Fig. 4 to 6 show examples of SiPM arrays divided into zones. An example timing pickup circuit corresponding to a single region of the SiPM array is shown in fig. 7. Fig. 8 illustrates an example method for processing signals from an SiPM array.

Although a PET imaging system is described by way of example, it will be appreciated that the present techniques may also be useful when applied to images acquired using other imaging modalities, such as CT, tomosynthesis, MRI, C-arm angiography, and the like. The present discussion of a PET imaging modality is provided merely as an example of one suitable imaging modality.

As used herein, the phrase "reconstructing an image" is not intended to exclude embodiments of the present invention in which data representing an image is generated rather than a viewable image. Thus, as used herein, the term "image" broadly refers to both a viewable image and data representing a viewable image. However, many embodiments generate (or are configured to generate) at least one viewable image.

In one example, an analog Application Specific Integrated Chip (ASIC) may include a one-to-one coupling between a single detector crystal and the sipms such that each SiPM is read out individually. However, to account for compton scattering between crystals and reduce the cost of associated electronics (time-to-digital converters (TDCs), analog-to-digital converters (ADCs), FPGAs, etc.), the input signals from the SiPM array may be combined into one timing channel. The response of a photon detector in the absence of light is called a dark count. In sipms, thermionic emission of electrons is a major source of dark counts. During the combination of the input signals from the SiPM array along with the actual signals, the dark counts from the sipms are also summed. In order to keep the CTR within a certain range, it is desirable to reduce the influence of dark counts on the CTR.

With one-to-one coupling between a single crystal and the sipms, a dark count of a single SiPM (such as caused by thermionic emission of electrons) may be added to the gamma ray signal regenerated from the SiPM. However, due to compton scattering, some gamma rays may interact with multiple detector crystals. For example, when a gamma ray is scattered, the energy of the gamma ray may split over two or more crystals, which reduces the magnitude of the signal into the comparator and degrades the Coincidence Timing Resolution (CTR) of compton scattered gamma rays. To overcome the effects of compton scattering, rather than transmitting signals from a single SiPM to a single timing pick-up circuit, signals from an array of sipms may be summed and transmitted to a single timing pick-up circuit. As the number of SiPMs in a detector tile increases, CTR may be improved, while the number of detector tiles of the system may be reduced, thereby reducing the cost of associated electronic components.

However, the dark counts from each SiPM in the array may be added to the timing pickup circuit in the input signal, which may increase the noise associated with the signal. The increased dark count may degrade CTR. The dark count effect on CTR increases due to the increased number of sipms in the detector block. To limit the effect of dark counts on CTR, a system is proposed that limits the number of SiPM inputs to one timing pick-up circuit by adding additional timing pick-up circuits without changing the size of the detector block and the low cost of the associated electronics.

For example, the SiPM array may be divided into two or more regions, with the signal from each region serving as an input signal for a single timing pick-up circuit. Dark counts from sipms in a single region may be summed in the input signal. By summing the dark counts from a lower number of sipms, the adverse effect of the dark counts on the input signal may be reduced. In this way, the adverse effects of compton scattering can be reduced by incorporating an array of sipms, and the adverse effects of dark count summation can be reduced by dividing the array of sipms into a plurality of regions, each region corresponding to a separate timing pick-up circuit.

If each partitioned area in the SiPM array is small, there may be a non-negligible amount of compton events, which may degrade CTR. To improve the CTR caused by inter-region compton scattering, an overlap region can be created by replicating the SiPM signal in the overlap region, which can fully capture the energy of the inter-region compton scattering, and adding one or more timing pick-up circuits. Signals from the plurality of timing pickup circuits may be directed to an or gate, and the timing signal that first arrives at the or gate may be transmitted to a time-to-digital converter. By keeping the signal delay line from the SiPM to the timing pick-up circuit and then to the or gate the same, the largest of the signals of the zone arrives first at the or gate.

Various embodiments of the present invention provide a multi-modality imaging system 10 as shown in figures 1 and 2. The multi-modality imaging system 10 may be any type of imaging system, for example, different types of medical imaging systems, such as Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), Computed Tomography (CT), ultrasound systems, Magnetic Resonance Imaging (MRI), or any other system capable of generating tomographic images. The various embodiments are not limited to multi-modality medical imaging systems, but may be used in single modality medical imaging systems, such as, for example, standalone PET imaging systems or standalone SPECT imaging systems. Furthermore, the various embodiments are not limited to medical imaging systems for imaging human subjects, but may include veterinary or non-medical systems for imaging non-human subjects.

Referring to fig. 1, a multi-modality imaging system 10 includes a first modality unit 11 and a second modality unit 12. The two modality units enable the multi-modality imaging system 10 to scan a subject or patient in a second modality using the second modality unit 12. The multi-modality imaging system 10 allows multiple scans in different modalities in order to improve the diagnostic capabilities of a single modality system. In one embodiment, the multi-modality imaging system 10 is a computed tomography/positron emission tomography (CT/PET) imaging system 10, for example, the first modality 11 is a CT imaging system 11 and the second modality 12 is a PET imaging system 12. The CT/PET system 10 is shown to include a gantry 13 representing a CT imaging system and a gantry 14 associated with a PET imaging system. As described above, modalities other than CT and PET may be employed with the multi-modality imaging system 10.

Gantry 13 includes an X-ray source 15 that projects a beam of X-rays toward a detector array 18 on the opposite side of gantry 13. Detector array 18 is formed by a plurality of detector rows (not shown) including a plurality of detector elements that together sense the projected x-rays that pass through medical patient 22. Each detector element produces an electrical signal that represents the intensity of an incident x-ray beam and thus allows the attenuation of the beam as it passes through patient 22 to be estimated. During a scan to acquire X-ray projection data, the gantry 13 and the components mounted thereon rotate about a center of rotation.

Fig. 2 is a block schematic diagram 200 of the PET imaging system 12 shown in fig. 1, in accordance with an embodiment of the present invention. The PET imaging system 12 includes a detector ring assembly 40 that includes a plurality of detector blocks. The PET imaging system 12 also includes a controller or processor 44 to control the normalization, image reconstruction process, and perform calibration. The controller 44 is coupled to an operator workstation 46. The controller 44 includes a data acquisition processor 48 and an image reconstruction processor 50 interconnected via a communication link 52. The PET imaging system 12 acquires scan data and transmits the data to the data acquisition processor 48. The scanning operation is controlled from an operator workstation 46. The data acquired by the data acquisition processor 48 is reconstructed using an image reconstruction processor 50.

The detector ring assembly 40 includes a central opening in which an object or patient, such as patient 22, may be positioned using, for example, a motorized table 24 (shown in fig. 1). The motorized table 24 is aligned with the central axis of the detector ring assembly 40. The motorized table 24 moves the patient 22 into the central opening of the detector ring assembly 40 in response to one or more commands received from the operator workstation 46. A PET scanner controller 54 (also referred to as a PET gantry controller) is disposed (e.g., mounted) within the PET system 12. The PET scanner controller 54 responds to commands received from the operator workstation 46 through the communication link 52. Accordingly, the scanning operation is controlled from the operator workstation 46 by the PET scanner controller 54.

During operation, when a photon collides with a crystal in the detector block 62 on the detector ring 40, it produces a scintillation event on the crystal. When a scintillation event occurs, each photomultiplier tube or photosensor generates an analog signal that is transmitted over communication line 64. A set of acquisition circuits 66 is provided to receive these analog signals. Acquisition circuitry 66 generates digital signals indicative of the three-dimensional (3D) position of the event and the total energy. The acquisition circuit 66 also generates event detection pulses that indicate the time or moment at which the scintillation event occurred. These digital signals are transmitted over a communication link (e.g., cable) to event locator circuitry 68 in the data acquisition processor 48.

The data acquisition processor 48 includes an event locator circuit 68, an acquisition CPU 70 and a coincidence detector 72. The data acquisition processor 48 periodically samples the signals generated by the acquisition circuitry 66. The acquisition CPU 70 controls the backplane bus 74 and the communication over the communication link 52. The event locator circuitry 68 processes the information about each valid event and provides a set of digital numbers or values indicative of the detected event. For example, the information indicates when an event occurred and the position of the scintillation crystal in the detector block 62 that detected the event. The event data packets are transmitted over the backplane bus 74 to the coincidence detector 72. The coincidence detector 72 receives the event data packets from the event locator circuitry 68 and determines whether any two of the detected events coincide. Coincidence is determined by a number of factors. First, the time stamps in each event data packet must be within a predetermined time period of each other, e.g., 4.5 nanoseconds. Second, the line of response (LOR) formed by the straight line joining the two detectors that detect the coincidence event should pass through the field of view in the PET imaging system 12. Events that cannot be paired are discarded. The coincident event pairs are located and recorded as coincident data packets that are communicated over the physical communication link 78 to a classifier/histogram generator 80 in the image reconstruction processor 50.

The image reconstruction processor 50 includes a classifier/histogram generator 80. During operation, the classifier/histogram generator 80 generates a data structure called a histogram. The histogram includes a large number of cells, where each cell corresponds to a unique pair of detector crystals in the PET scanner. Because PET scanners typically include thousands of detector crystals, histograms typically include millions of cells. Each cell of the histogram also stores a count value representing the number of coincidence events detected by a pair of detector crystals of that cell during a scan. At the end of the scan, the data in the histogram is used to reconstruct an image of the patient. A complete histogram containing all the data from a scan is commonly referred to as a "result histogram". The term "histogram" generally refers to the components of the scanner, such as the processor and memory, that perform the function of creating a histogram.

The image reconstruction processor 50 also includes a memory module 82, an image CPU 84, an array processor 86 and a communication bus 88. During operation, the classifier/histogram generator 80 counts all events occurring along each projection ray and organizes the events into 3D data. The 3D data or sinogram is organized into a data array 90 in an exemplary embodiment. The data array 90 is stored in the memory module 82. The communication bus 88 is linked to the communication link 52 through the image CPU 84. The image CPU 84 controls communication through a communication bus 88. The array processor 86 is also connected to a communication bus 88. The array processor 86 receives as input a data array 90 and reconstructs an image in the form of an image array 92. The resulting image array 92 is then stored in the memory module 82.

The images stored in the image array 92 are communicated by the image CPU 84 to the operator workstation 46. The operator workstation 46 includes a CPU 94, a display 96, and an input device 98. The CPU 94 is connected to the communication link 52 and receives input, such as user commands, from an input device 98. The input device 98 may be, for example, a keyboard, a mouse, a touch screen panel, and/or a voice recognition system, among others. Through the input device 98 and associated control panel switches, an operator can control the operation of the PET imaging system 12 and the positioning of the patient 22 for scanning. Similarly, an operator may use a program executed by the workstation CPU 94 to control the display of the resulting image on the display 96 and may perform image enhancement functions.

The detector ring assembly 40 includes a plurality of detector cells. The detector unit may include a plurality of detectors, a light guide, a scintillation crystal, and an analog Application Specific Integrated Chip (ASIC). For example, the detector unit may include twelve silicon photomultiplier (SiPM) devices, four light guides, 144 scintillation crystals, and two analog ASICs.

For example, the detector block 62 may include an array of scintillation crystals and an array of SiPM devices. The SiPM devices may be divided into two or more zones, wherein the SiPM devices in the two or more zones transmit signals to two or more different timing pick-up circuits. Each of the two or more zones in the array of SiPM devices may include at least one SiPM device. In one example, the at least one SiPM device may be included in one of two or more regions, each of the two or more regions being mutually exclusive. In another example, the at least one SiPM device may be included in two of the two or more regions, the two of the two or more regions overlapping each other. Each of the two or more regions may transmit a signal to one of two or more different timing pick-up circuits via the output array. The output array may include a plurality of output channels, wherein a number of output channels in the output array is equal to a number of SiPM devices in a region coupled to the output array, wherein each SiPM device maps to an output channel in the output array. The output channels may receive analog signals from the SiPM devices, and may sum each analog signal from each output channel in the output array to generate an input signal for a timing pick-up circuit coupled to the output array, the analog signals generated by collecting scintillation photons with the SiPM devices.

Each of the two or more different timing pick-up circuits may include a summing amplifier, a capacitor, and a comparator connected in series, each of the timing pick-up circuits comparing an input signal with a threshold signal and generating a square pulse signal in response to the input signal being higher than the threshold signal. Each timing pick-up circuit output may be coupled to a logic circuit such as an or gate. The logic circuit may receive the square pulse signal from the two or more timing pickup circuits and transmit the square pulse signal that first reaches the logic circuit to a time-to-digital converter (TDC). The TDC may be part of the acquisition circuitry 66 of the PET imaging system.

An example detector block having a plurality of sipms is shown in fig. 3 arranged in an array. Thus, each SiPM may also include a plurality of pixels (e.g., 6). An example in which the detector unit 300 comprises sixteen sipms is shown in fig. 3. In this example, each SiPM 302 includes a plurality of pixels. For example, the SiPM 302 may include 6 pixels. Thus, the detector unit 300 then comprises a total of 96 pixels (determined by 6X 16). The signal outputs from each of the sipms may be summed, and the summed signal may be used as an input signal for a timing pick-up circuit. However, by summing the signal outputs from all the sipms in the array, the overall dark count can be amplified, thereby affecting signal quality. As shown in fig. 4-7, the SiPM array may be divided into a plurality of regions, with each region corresponding to a timing pick-up circuit.

Fig. 4 shows a first example 400 of a detector block 402 comprising sixteen individual sipms 404 forming an array. The sipms 404 may be arranged in a 4 x 4 matrix. The sixteen sipms may be divided into two separate regions, with the top eight sipms forming a first region 406 and the lower eight sipms forming a second region 408. The zone division as shown here is an example configuration, and any number of sipms may be configured as zones. In one example, the first zone may include 7 sipms and the second zone may include the remaining 9 sipms.

The sipms from the first region 406 may correspond to the first output array 410. The first output array 410 may include eight separate output channels 411 (also referred to herein as front-end amplifiers), where each output channel 411 receives signals directly from one SiPM. Each output channel 411 may be mapped to a single SiPM in the first region 406. Similarly, sipms from the second region 408 may correspond to the second output array 412. The second output array 412 may include eight separate output channels 413, where each output channel 413 receives signals directly from one SiPM. Each output channel 413 may be mapped to a single SiPM in the second region 408.

The first output array 410 may receive individual signals from eight sipms and sum the signals to form a single input signal for the first timing pick-up circuit 414. The second output array 412 may receive individual signals from eight sipms and sum the signals to form a single input signal for the second timing pick-up circuit 416. By conveying signals from multiple sipms to a single timing pick-up circuit, the adverse effects of compton scattering on signal quality can be reduced. By dividing the sipms into two groups, the cumulative dark counts in the input signals for the first timing pickup circuit 414 and the second timing pickup circuit 416 may be individually reduced relative to the cumulative dark counts in the input signals obtained from summing all sixteen sipms in the detector unit. In this way, by including an SiPM array in the detector block and separately processing the signals from the regions in the array, the adverse effects of Compton scattering and dark count accumulation can be reduced.

An example timing pick-up circuit 700 is shown in fig. 7. The timing pick-up circuit 700 may be the first timing pick-up circuit 414 or the second timing pick-up circuit 416 in fig. 4. The timing pick-up circuit includes a summing amplifier 702, a capacitor 710, and a comparator 704 connected in series.

The output array may sum the signals received from the individual sipms and generate an input signal 706 for the summing amplifier 702. At summing amplifier 702, all input signals are summed and may be amplified with a low noise and high bandwidth amplifier. The output signal 708 from the summing amplifier 702 may pass through a capacitor 710 where only the high frequency components of the signal pass through to improve CTR, while the low frequency electronic noise and low frequency components of the summed signal 708 are filtered out. After passing through the capacitor 710, the signal 712 passes through the comparator 704. At the comparator, the signal 712 is compared to a threshold signal 714, and if the signal 712 is higher than the threshold signal 714, a square pulse may be generated. The square pulse may be referred to as a hit signal generated from timing pick-up circuit 700.

Returning to fig. 4, the respective hit signals generated from the first timing fetch circuitry 414 and the second timing fetch circuitry 416 can be transmitted to an or gate 418. At the or gate, the first arrival hit signal between the two binary signals (hit signals) generates an output that is transmitted to the TDC 420. Thus, when the signal trace length remains the same, the largest signal in the signal 706 that reaches the timing pick comparator 704 may generate a hit signal first and reach the OR gate 418 first.

The signal from the or gate 418 may then be transmitted to a time-to-digital converter (TDC) 420. The TDC 420 may identify events in the form of signals arriving at the TDC from the or gate 418 and provide a digital representation of the times at which they occurred. For example, a TDC may output the arrival time of each input signal. In one example, each of the first timing pick-up circuit 414, the second timing pick-up circuit 416, the or gate 418, and the TDC 420 may be part of an acquisition circuit of a PET imaging system (such as the acquisition circuit 66 in fig. 2).

Compton scattering may occur between two regions in the SiPM array in the detector block 402. To further reduce the effects of inter-region compton scattering and improve CTR, the overlapping region may be included by replicating the SiPM signal in the overlapping region (which may fully capture the energy of inter-region compton scattering) and adding one or more timing pickup circuits.

Fig. 5 shows a second example 500 of a detector unit 502 comprising sixteen individual sipms 504 divided into overlapping areas corresponding to individual timing pick-up circuits. The sipms may be arranged in a 4 x 4 matrix. The sixteen sipms may be divided into three regions, with the top eight sipms forming a first region 506, the lower eight sipms forming a second region 508, and the middle eight sipms forming a third region 510. Four sipms in the third zone 510 are shared with the first zone 506, while four other sipms in the third zone 510 are shared with the second zone 508. As such, the third region 510 overlaps each of the first region 506 and the second region 508. The zone division as shown here is an example configuration, and any number of sipms may be configured as zones.

The sipms from the first region 606 may correspond to the first output array 512. The first output array 512 may include eight separate output channels 511, where each output channel 511 receives signals directly from one SiPM. Each output channel 511 may be mapped to a single SiPM in the first region 506. Similarly, sipms from the second region 508 may correspond to the second output array 514. The second output array 514 may include eight individual output channels 513, with each output channel 513 receiving a signal directly from one SiPM. Each output channel 513 may be mapped to a single SiPM in the second region 508. The third output array 516 may include eight separate output channels 515, where each output channel 515 receives signals directly from one SiPM. Each output channel 515 may be mapped to a single SiPM in the third region 510. Thus, each SiPM in the third region 510 provides an output to two output channels.

In one example, sipms in the third region 510 provide outputs to each of output channels 511 in the first output array 512 and output channels 515 in the third output array 516. In another example, sipms in the third region 510 provide outputs to each of the output channels 513 in the second output array 514 and the output channels 515 in the third output array 516. In this way, by replicating the signals from multiple sipms, the adverse effects of compton scattering between regions may be reduced and the signal-to-noise ratio may be improved. The replication of the signal from the SiPM may be done at the output channel.

First output array 512 may receive individual signals from eight sipms and sum the signals to form a single input signal for first timing pickup circuit 518. Second output array 514 may receive individual signals from eight sipms and sum the signals to form a single input signal for second timing pick-up circuit 522. The third output array 516 may receive individual signals from eight sipms and sum the signals to form a single input signal for the third timing pick-up circuit 520.

The respective hit signals generated from the first timing fetch circuit 518, the second timing fetch circuit 522, and the third timing fetch circuit 520 may be transmitted to an or gate 524. The signal trace lengths from the sipms 504 to the or gate 524 may be matched between subgroups, such as sipms in the first zone, the second zone, and the third zone. At the or gate, the first arrival hit signal between the three signals (hit signals) may generate an output pulse to be transmitted to the TDC. Whichever hit signal (from one of the first, second and third timing pick-up circuits 518, 522 and 520) first arrives at the or gate will be transferred to a time-to-digital converter (TDC) 526. The TDC 526 may identify events in the form of signals arriving at the TDC from the or gate 526 and provide a digital representation of the times at which they occur.

Fig. 6 shows a third example 600 of a detector block 602 comprising 36 individual sipms 604 divided into overlapping regions corresponding to individual timing pick-up circuits. The sipms may be arranged in a 6x 6 matrix. As the size of the detector block becomes larger with more sipms, the cost of the associated electronics may be reduced. However, the total dark count may increase with more sipms. The 36 sipms may be divided into four regions to reduce the effect of dark counts. Twelve sipms in the upper left corner of the 6x 6 array may form the first region 606, twelve sipms in the upper right corner of the 6x 6 array may form the second region 608, twelve sipms in the lower left corner of the 6x 6 array may form the third region 610, and twelve sipms in the lower right corner of the 6x 6 array may form the fourth region 612.

The first zone 606 overlaps each of the second zone 608 and the third zone 610, with three shared sipms located between the first zone and the second zone, and three other shared sipms located between the first zone and the third zone. The second zone 608 overlaps each of the first zone 606 and the fourth zone 612, with three shared sipms located between the first zone and the second zone, and three other shared sipms located between the second zone and the fourth zone. The third zone 610 overlaps each of the first zone 606 and the fourth zone 612, with three shared sipms located between the third zone and the first zone, and three other shared sipms located between the third zone and the fourth zone. A fourth zone 612 overlaps each of the second and third zones 608, 610, with three shared sipms located between the fourth and second zones and three other shared sipms located between the fourth and third zones.

All sipms in the third region 510 in fig. 5 overlap with adjacent regions. In fig. 6, only a portion of the sipms in a zone overlap adjacent zones to minimize the number of output channels 614, 616, 618, 620 and timing pick-up circuits 622, 624, 626, 628. Minimization of the necessary electronics can reduce both power consumption and electronic noise sources of the ASIC. The zones in fig. 6 are example embodiments, and the size of the zones may be adjusted based on the amount of dark counts from each SiPM, the size of the SiPM, the target size of the block detector, and the expectation of the CTR level.

The zone division as shown here is an example configuration, and any number of sipms may be configured as overlapping zones.

The sipms from the first region 606 may correspond to the first output array 614. The first output array 614 may include eight separate output channels 613, with each output channel 613 receiving signals directly from one SiPM. Each output channel 613 may be mapped to a single SiPM in the first region 606. Similarly, the sipms from the second region 608 may correspond to the second output array 616. The second output array 616 may include eight individual output channels 615, where each output channel 615 receives signals directly from one SiPM. Each output channel 615 may be mapped to a single SiPM in the second region 608. The third output array 620 may include eight individual output channels 619, where each output channel 619 receives a signal directly from one SiPM. Each output channel 619 may be mapped to a single SiPM in the third region 610. The fourth output array 618 may include eight separate output channels 617, where each output channel 617 receives signals directly from one SiPM. Each output channel 617 may be mapped to a single SiPM in the fourth region 612.

In one example, sipms in the first region 606 may provide outputs to each of the output channels 613 in the first output array 614 and the output channels 615 in the second output array 616. In another example, another SiPM in the first region 606 may provide an output to each of the output channels 613 in the first output array 614 and the output channels 619 in the third output array 620. In this way, by replicating the signals from multiple sipms, the adverse effects of compton scattering between regions may be reduced and the signal-to-noise ratio may be improved.

The first output array 614 may receive individual signals from eight sipms and sum the signals to form a single input signal for the first timing pickup circuit 622. The second output array 616 may receive individual signals from eight sipms and sum the signals to form a single input signal for the second timing pick-up circuit 624. The third output array 620 may receive individual signals from eight sipms and sum the signals to form a single input signal for the third timing pick-up circuit 628. The fourth output array 618 may receive individual signals from eight sipms and sum the signals to form a single input signal for the fourth timing pick-up circuit 626.

The respective hit signals generated from each of the first, second, third and fourth timing pick-up circuits 622, 624, 628 and 626 may be transmitted to an or gate 630. At the or gate, the first arrival hit signal of the four hit signals may generate an output of the or gate. Whichever hit signal (from one of the first timing picker circuit 622, the second timing picker circuit 624, the third timing picker circuit 628, and the fourth timing picker circuit 626) arrives first at the or gate, timing digitization may be initiated in a time-to-digital converter (TDC) 632. By design, when the signal trace lengths remain the same, the largest signal in the outputs of the output array of 614, 616, 618, 620 may first generate a hit signal at the timing pick-up circuits 622, 624, 626, 628 and first reach the or gate 630. The maximum signal may comprise more collected SiPM signals that minimize the effects of compton scattering. TDC 632 may recognize events in the form of signals that arrive at TDC from or gate 630 and provide a digital representation of the time at which they occur.

Thus, the system shown in fig. 1 to 7 provides: a detector ring comprising a plurality of detector blocks, each detector block comprising an array of scintillation crystals and an array of silicon photomultiplier (SiPM) devices divided into two or more regions, wherein each region comprises at least one SiPM device; and two or more timing pickup circuits, wherein each of the two or more timing pickup circuits is coupled to one of the two or more regions via a different output array. Two or more timing pick-up circuits may transmit respective signals from two or more regions of the array to a single logic circuit. The two or more zones may include at least one common SiPM device coupled to at least two timing pick-up circuits.

Fig. 8 illustrates a high-level flow chart showing an example method 800 for processing signals from a silicon photomultiplier (SiPM) array. The method 800 may be performed using the systems and components described above with reference to fig. 1-7. For example, it may be implemented by a combination of an analog ASIC and a TDC or hybrid ASIC. However, it should be understood that the method may be performed using different systems and components without departing from the scope of the present disclosure.

At 802, an analog signal is generated at each SiPM in a detector block (such as SiPM 404 in fig. 4) corresponding to a scintillation event. The detector block may include a plurality of sipms arranged in an array. The sipms within the array may be divided into two or more regions. When a photon collides with a detector crystal on the detector ring, it produces a scintillation event on the crystal. When a scintillation event occurs, each SiPM that makes up the crystal produces an analog signal.

At 804, signals from each SiPM in a zone (such as the first zone 406 in fig. 4) may be transmitted to a dedicated output channel (such as the output channel 411 in fig. 4). The output channels may be part of an output array (such as output array 410 in fig. 4). The output array may include a plurality of output channels, where each output channel corresponds to a particular SiPM within the region. Each region within the SiPM array may correspond to an output array. For example, a region with eight sipms may correspond to an output array with eight output channels.

At 806, the signals from each output channel within the output array may be summed. In this way, the signals from all the sipms within the area may be summed in the output array. At 808, the summed signals from the output array may be transmitted to a timing pick-up circuit. Each output array may correspond to a particular timing pick-up circuit. In this way, the signals from each region in the SiPM array are summed and transmitted to the corresponding timing pick-up circuit.

At 810, at the timing pick-up circuit, a signal is transmitted through an amplifier, a capacitor, and a comparator. At the timing pick-up circuit, the signal is compared to a threshold signal and if the signal is higher than the threshold signal, a square pulse may be generated. The square pulse may be referred to as a hit signal generated from the timing pick-up circuit. A hit signal may be generated at each timing pick-up circuit.

At 812, the hit signal from each timing pick circuit may be transmitted to an OR gate (such as OR gate 418 in FIG. 4). At 814, whichever hit signal arrives first at the OR gate, it may be transmitted to a time-to-digital converter (such as TDC 420 in FIG. 4). At 816, the TDC may provide a digital representation of the time at which the flicker event occurred. For example, a TDC may output the arrival time of each incoming signal.

At 818, the digital signal generated at TDC may be transmitted to a data acquisition processor (such as the data acquisition processor 48 in fig. 2). The data acquired by the data acquisition processor is reconstructed using an image reconstruction processor.

In this manner, a first signal generated at a silicon photomultiplier (SiPM) device included in a first area of the array of SiPM devices may be transmitted to the first timing pick-up circuit via the first output array. A first hit signal corresponding to a first area of the array of SiPM devices may be generated at the first timed pick circuit, a second signal generated at the SiPM devices included in a second area of the array of SiPM devices may be transmitted to the second timed pick circuit via the second output array, a second hit signal corresponding to a second area of the array of SiPM devices may be generated at the second timed pick circuit, and one of the first hit signal and the second hit signal may be transmitted via a logic circuit coupled to each of the first timed pick circuit and the second timed pick circuit to reduce the dark count.

Thus, the CTR can be improved even if the number of sipms in the detector block is increased. The technical effect of dividing the SiPM array into two or more regions, with the signal from each region serving as an input signal for a single timing pick-up circuit, is that the adverse effects of dark counts can be reduced. By summing the dark counts from a smaller number of sipms, signal quality can be improved. By dividing the SiPM array into overlapping regions and adding one or more additional timing pickup circuits, the SiPM signals can be replicated in the overlapping regions and the CTR of the inter-region compton scattered signals can be improved.

As used herein, an element or step recited in the singular and proceeded with the word "a" or "an" should be understood as not excluding plural said elements or steps, unless such exclusion is explicitly recited. Furthermore, references to "one embodiment" of the present invention are not intended to be interpreted as excluding the existence of additional embodiments that also incorporate the recited features. Moreover, unless explicitly stated to the contrary, embodiments "comprising," "including," or "having" an element or a plurality of elements having a particular property may include additional such elements not having that property. The terms "including" and "in. Furthermore, the terms "first," "second," and "third," etc. are used merely as labels, and are not intended to impose numerical requirements or a particular positional order on their objects.

This written description uses examples to disclose the invention, including the best mode, and also to enable any person skilled in the relevant art to practice the invention, including making and using any devices or systems and performing any incorporated methods. The patentable scope of the invention is defined by the claims, and may include other examples that occur to those of ordinary skill in the art. Such other examples are intended to be within the scope of the claims if they have structural elements that do not differ from the literal language of the claims, or if they include equivalent structural elements with insubstantial differences from the literal languages of the claims.