阅读说明：本技术 多模态康普顿和单光子发射计算机断层摄影医学成像系统 (Multi-modal compton and single photon emission computed tomography medical imaging system ) 是由 A·H·维贾 M·罗德里格斯 于 2018-08-07 设计创作，主要内容包括：一种多模态成像系统允许可选择的光电效应和/或康普顿效应检测。摄像机或检测器是具有捕集器检测器(13)的模块(11)。根据用途或设计,散射检测器(12)和/或编码物理孔径(110)相对于患者空间定位在捕集器检测器(13)之前。对于低能量,通过散射检测器(12)的发射继续通过编码孔径(110),以由捕集器检测器(13)使用光电效应来检测。或者,不提供散射检测器(12)。对于较高能量,一些发射在散射检测器(12)处散射,并且从散射所产生的发射经过或通过编码孔径(110),以在用于使用康普顿效应进行检测的捕集器检测器(13)处被检测。或者,不提供编码孔径(110)。相同的模块(11)可以用于使用光电效应和康普顿效应两者进行检测,其中,散射检测器(12)和编码孔径(110)两者都设有捕集器检测器(13)。多个模块(11)可以定位在一起以形成更大的摄像机,或者单独使用模块(11)。通过使用模块(11),可以使用任何数量的模块(11)来与多模态成像系统进行配合。一个或多个这样的模块(11)可以被添加到用于多模态成像系统的另一成像系统(例如,CT或MR)。(A multi-modality imaging system allows for selectable photoelectric effect and/or compton effect detection. The camera or detector is a module (11) with a catcher detector (13). Depending on the application or design, the scatter detector (12) and/or the coded physical aperture (110) are spatially positioned in front of the trap detector (13) with respect to the patient. For low energies, emissions through the scatter detector (12) continue through the coded aperture (110) to be detected by the trap detector (13) using the photoelectric effect. Alternatively, no scatter detector (12) is provided. For higher energies, some of the emissions are scattered at a scatter detector (12) and the resulting emissions from the scattering pass through or past a coded aperture (110) to be detected at a trap detector (13) for detection using the compton effect. Alternatively, no coded aperture (110) is provided. The same module (11) can be used for detection using both the photoelectric effect and the compton effect, wherein both the scatter detector (12) and the coded aperture (110) are provided with a trap detector (13). Multiple modules (11) may be positioned together to form a larger camera, or modules (11) may be used individually. By using modules (11), any number of modules (11) may be used to cooperate with the multi-modality imaging system. One or more of such modules (11) may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.)

1. A multi-modality medical imaging system, comprising:

a first module (11) having a first trap detector (13), a location of a first scatter detector (12) spaced apart from the trap detector (13), and a location of a first physical aperture (110) between a patient space and the first trap detector (13); and

an image processor (19) configured to determine an angle of incidence of Compton events if the first scatter detector (12) is comprised in the first module (11) and to count photo-electric events if the first physical aperture (110) is comprised in the first module (11).

2. The multi-modality medical imaging system of claim 1, wherein the first physical aperture (110) is at a location of the first physical aperture (110), and the first physical aperture (110) includes a coded aperture of lead or tungsten.

3. The multi-modality medical imaging system of claim 2, wherein the coded aperture comprises a temporally coded aperture that is rotatable about an axis and/or translatable in a plane perpendicular to the axis to cast shadows having different positions on the first trap detector (13).

4. The multi-modality medical imaging system of claim 1, wherein the first physical aperture (110) is at a location of the first physical aperture (110) and the first trap detector (13) and the first physical aperture (110) are parallel, the first physical aperture (110) having a shadow on the first trap detector (13) in a central region of the first trap detector (13) but not in an outer region of the first trap detector (13), and wherein the image processor (19) is configured to count photo-events from the central region but not the outer region and to determine incident angles of photon interaction events and compton events primarily from the outer region.

5. The multi-modality medical imaging system of claim 1, further comprising a second module (11) having a second trap detector (13) and locations for a second scatter detector (12) and a second physical aperture (110); and

wherein the first and second modules (11) are three-, five-, or six-sided in a cross-section orthogonal to a radial direction from the patient space.

6. The multi-modality medical imaging system of claim 5, wherein the first and second modules (11) are cylindrically symmetric, a narrowest end of each of the first and second modules (11) being closest to a patient space of the medical imaging system, a widest end of each of the first and second modules (11) being furthest from the patient space.

7. The multi-modality medical imaging system of claim 1, wherein the first module (11) further includes a circuit board orthogonal to the first trap detector (13), an application specific integrated circuit having the first trap detector (13), a flex circuit connecting the application specific integrated circuit to the circuit board, and a location for one or more additional trap layers and/or scattering layers between the first trap layer and the first scattering layer.

8. The multi-modality medical imaging system of claim 1, wherein the first module (11) is a partial ring or a portion of a ring (120) around a patient space of the medical imaging system.

9. The multi-modality medical imaging system of claim 8, further including an additional module (11) for a ring (130) or partial ring and for another ring (132) or partial ring that intersects the ring or partial ring at two of the additional modules (134).

10. The multi-modality medical imaging system of claim 9, wherein the ring (130) or partial ring and the other ring (132) or partial ring are separated by 90 degrees.

11. The multi-modality medical imaging system of claim 8, further comprising an additional ring or partial ring of modules (11) axially adjacent to the ring or partial ring with the first module (11), the additional ring or partial ring and the ring or partial ring forming a portion (140) of a geodesic dome.

12. The multi-modality medical imaging system of claim 1, wherein the first scatter detector (12) is at a location of the first scatter detector (12) in the module (11) and the first physical aperture (110) is at a location of the first physical aperture (110) in the module (11), and wherein the image processor (19) is configured to generate a single photon emission computed tomography image from the counts and a compton image from the compton events, and further comprising a display configured to display the single photon emission computed tomography image and the compton image.

13. The multi-modality medical imaging system of claim 1, wherein the first scatter detector (12) is included in the first module (11) at a location for the first scatter detector (12) if a relatively higher energy is to be detected, and wherein the first physical aperture (110) is included in the first module (11) at a location for the first physical aperture (110) if a relatively lower energy is to be detected.

14. A medical imaging system, comprising:

solid state detector modules (11), each having a first detector (13) arranged for use with either or both of the plate (110) forming the coded aperture and the scatter detector (12);

the solid state detector modules (11) have three, five or six sides in a cross-section normal to a radial direction from a longitudinal patient axis such that the solid state detector modules (11) are stacked together to form a portion of a geodesic dome.

15. The medical imaging system of claim 14, wherein each of the solid state detector modules (11) further comprises the scatter detector (12) and the plate (110), the plate (110) being between the scatter detector (12) and the first detector (13), further comprising an image processor (19) configured to detect emissions with the photoelectric effect using the plate (110) and the first detector (13), and to detect emissions with the compton effect using the scatter detector (12) and the first detector (13).

16. Medical imaging system according to claim 14, wherein each of the solid state detector modules (11) comprises the plate (110) which is rotatable and/or translatable with respect to the first detector (13) within the respective solid state detector module (11).

17. The medical imaging system of claim 14, wherein the stack forming part of the geodesic dome comprises two separate rings (130, 132) sharing two of the solid-state modules (11).

18. A method for forming a compton camera and/or a single photon emission computed tomography camera, the method comprising:

accommodating a trap detector (13) in a housing (21), the trap detector (13) being arranged for relatively low emission energy with a coded aperture (110) and for relatively high emission energy with a scatter detector (12), the housing (21) being shaped as a part of a geodesic dome; and

the housing (21) is mounted relative to a patient bed (60) having a selected one or both of the coded aperture (110) and the scatter detector (12).

19. The method of claim 18, wherein installing comprises forming a loop (120) or partial loop with the housing (21) and an additional housing of the housing (21) as part of a multi-modality system that includes the compton camera using the scatter detector (12) in the housing (21) and a single photon emission computed tomography imaging system using the coded aperture (110) in the housing (21).

20. The method of claim 18, further comprising:

detecting a first emission as a Compton event with the scatter detector (12) and the trap detector (13); and

detecting a second emission as a photo-electric event through the coded aperture (110) with the trap detector (13).

Background

The present embodiments relate to nuclear imaging, such as Single Photon Emission Computed Tomography (SPECT) imaging. Slow-rotating large-field SPECT systems rely on the presence of a physical collimator. A parallel-hole collimator in combination with a position-sensitive detector forms the image. These collimated SPECT systems are limited to low energy photon emitting isotopes, such as Tc99m, depending on the photoelectric effect used to detect the emission from radioisotopes in the patient. Image quality and efficiency are key parameters of any image forming system used for SPECT medical applications. Improved sensitivity and image quality are increasing possibilities to image higher photon energies and desirable features in new SPECT image forming systems.

The compton effect allows higher energies to be imaged. The compton imaging system is configured as a test platform, for example, a scatter ring is assembled, and then the trap ring is mounted to the metro frame. The electronic device is connected to detect compton-based events from the emission of the phantom (phantom). Compton imaging systems fail to address the design and constraints of practical use in any commercial clinical environment. Current proposals lack the ability to integrate into the imaging platform in the clinic or lack the design and constraint requirements (i.e., flexibility and extensibility) to address the business needs.

Disclosure of Invention

By way of introduction, the preferred embodiments described below include methods and systems for medical imaging. A multi-modality imaging system allows for selectable photoelectric effect and/or compton effect detection. The camera or detector is a module with a trap detector. Depending on the application or design, the scatter detector and/or the coded physical aperture are spatially positioned in front of the trap detector with respect to the patient. For low energies, the emission through the scatter detector continues through the coded aperture to be detected by the trap detector using the photoelectric effect. Alternatively, no scatter detector is provided. For higher energies, some of the emissions are scattered at the scatter detector and the resulting emissions from the scatter pass through or through a coded aperture to be detected at a trap detector for detection using the compton effect. Alternatively, no coded aperture is provided. In case both the scatter detector and the coded aperture are provided with a trap detector, the same module can be used for detection using both the photo-electric effect and the compton effect. Multiple modules may be positioned together to form a larger camera, or the modules may be used individually. By using modules, any number of modules can be used to cooperate with the multi-modality imaging system. One or more of such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

In a first aspect, a multi-modality medical imaging system includes a first module having a first trap detector, a location for a first scatter detector spaced apart from the trap detector, and a location for a first physical aperture between patient space and the first trap detector. The image processor is configured to determine an angle of incidence of compton events if the first scatter detector is included in the first module, and count photoelectric events if the first physical aperture is included in the first module.

In a second aspect, a medical imaging system includes solid state detector modules, each having a first detector arranged for use with either or both of a plate forming a coded aperture and a scatter detector. The solid state detector modules have three, five or six sides in a cross-section normal to a radial direction from the longitudinal patient axis such that the solid state detector modules are stacked together to form a portion of a geodesic dome.

In a third aspect, a method for forming a compton camera and/or a single photon emission computed tomography camera is provided. The trap detector is housed in the housing. The trap detector is arranged to be available with the coded aperture for relatively low emission energies and with the scatter detector for relatively high emission energies. The housing is shaped as a portion of a geodesic dome. The housing is mounted relative to a patient bed having a selected one or both of the coded aperture and the scatter detector.

The present invention is defined by the following claims, and nothing in this section should be taken as a limitation on those claims. Other aspects and advantages of the invention are discussed below in conjunction with the preferred embodiments and may be claimed later, either individually or in combination.

Drawings

The components and figures are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the invention. Moreover, in the figures, like reference numerals designate corresponding parts throughout the different views.

FIG. 1 is a perspective view of a plurality of modules of a Compton camera in accordance with one embodiment;

FIG. 2 illustrates an exemplary scatter detector;

FIG. 3 illustrates an exemplary trap detector;

FIG. 4A is a side view of one embodiment of a Compton camera, FIG. 4B is an end view of the Compton camera of FIG. 4A, and FIG. 4C is a detailed view of a portion of the Compton camera of FIG. 4B;

FIG. 5 is a perspective view of one embodiment of a Compton camera in a medical imaging system;

FIG. 6 is a perspective view of one embodiment of a complete loop Compton camera in a medical imaging system;

FIG. 7 is a perspective view of one embodiment of a partial loop Compton camera in a medical imaging system;

FIG. 8 is a perspective view of one embodiment of a full-ring Compton camera with an axially extending partial ring in a medical imaging system;

FIG. 9 is a perspective view of one embodiment of a single module based Compton camera in a medical imaging system;

FIG. 10 is a flow chart of an exemplary embodiment of a method for forming a Compton camera;

FIG. 11 shows a scatter detector and a trap detector with an interventional (interventional) coded aperture for imaging using both the photoelectric effect and the Compton effect;

FIG. 12 is a perspective view of one embodiment of a full-ring multi-modal camera from a module shaped for a geodesic dome-like structure;

FIG. 13 is a perspective view of one embodiment of a dual loop multi-modal camera from a module shaped for a grid dome-like structure;

FIG. 14 is a perspective view of one embodiment of an axially stacked plurality of complete rings from a multi-modal camera of modules shaped for a geodesic dome-like structure;

FIG. 15 is a perspective view of one embodiment of a multi-modality camera formed of three modules shaped for a geodesic dome-like structure; and

FIG. 16 is a perspective view of one embodiment of a photoelectric effect camera formed from three modules shaped for a geodesic dome-like structure.

Drawings

Fig. 1-9 are directed to a multi-modal compatible compton camera. The modular design is used to form a compton camera for use with various other imaging modalities. Fig. 11-16 are directed to a modular design with a trap detector that can be used with a scatter detector for compton imaging or a coded aperture for SPECT imaging. The module provides a location for one or both of the scatter detector and the coded aperture. After summarizing alternative SPECT-Compton embodiments, the Compton camera of FIGS. 1-9 is described. Many of the features and components of the compton camera of fig. 1-9 are used with the SPECT-compton embodiment described in fig. 11-16.

For an alternative SPECT-Compton embodiment, a clinical multi-modality compatible and modular camera for medical imaging is provided. For lower energy emissions, a coded aperture may be included in each module for SPECT operation. For higher energy emissions, a scatter detector may be included in each module for Compton operation. The modular design allows sufficient flexibility so that alternative SPECT-compton cameras can be added to existing Computed Tomography (CT), Magnetic Resonance (MR), or Positron Emission Tomography (PET) platforms as axially separate systems or as fully integrated systems. Modularity allows for efficient manufacturing and serviceability. Improved sensitivity and image quality are increasing possibilities to image higher photon energies and desirable features in new SPECT image forming systems. Hybrid imaging uses the Compton effect for higher energies and the photoelectric effect with physical collimation for low energies 140.5keV, where both the scatter detector and the coded aperture are arranged in respective positions of the same module.

Referring to fig. 1-9, a medical imaging system includes a multi-modality compatible compton camera having a segmented detection module. The compton camera (e.g. compton camera ring) is segmented into modules that house the detection units. Each module is independent and when assembled into a ring or partial ring, the modules can communicate with each other. The modules are independent but can be assembled into a multi-module unit that produces a compton scatter-based image. A cylindrically symmetric module or a spherical shell segmented module may be used.

The scatter trap allows for a modular arrangement that is efficient to manufacture, serviceable in the field, and cost and energy efficient. The modules allow design freedom to vary the radius of each radial detection unit, the angular span and/or the axial span of a module. The scatter trap is multi-modal compatible to the modules and/or forms a modular loop compton camera for clinical emission imaging. This design allows flexibility so that the compton camera can be added to existing Computed Tomography (CT), Magnetic Resonance (MR), Positron Emission Tomography (PET), or other medical imaging platforms as an axially separate system or as a fully integrated system. Each module may address heat dissipation, data collection, calibration, and/or allow for efficient assembly and servicing.

Each scatter trap pair module is formed from a commercially suitable solid-state detector module (e.g., Si, CZT, CdTe, HPGe, or the like), allowing an energy range of 100-. Compton imaging can be set with a wider range of isotope energies (> 2 MeV) to enable new tracers/labels by selecting the scatter trap detector. Modularity allows individual modules to be removed or replaced, allowing time and cost efficient service. The modules may operate and isolate independently or may be linked for crosstalk, allowing for improved image quality and higher efficiency when detecting compton events using the scatter detector of one module and the trap detector of another module.

The modularity allows for a flexible design geometry optimized for individual needs, such as using a partial ring for integration with a CT system (e.g., connected between an X-ray source and a detector), several modules (e.g., tiles) for integration with a single photon emission computed tomography gamma camera or other spatially limited imaging system, or a complete ring. Functional imaging based on compton detection events can be added to other imaging systems (e.g., CT, MR, or PET). Multiple full or partial rings may be placed adjacent to each other for greater axial coverage of the compton camera. A dedicated or stand-alone compton-based imaging system may be formed. In one embodiment, the module includes a collimator of lower energy (e.g., < 300 keV), providing multi-channel and multiplexed imaging (e.g., high energy using a scatter trap detector for Compton events and low energy using one of the detectors for SPECT or PET imaging). The module may be stationary or rapidly rotating (0.1 rpm < omega < 240 rpm). Dimensional, installation, service, and/or cost constraints are addressed by the scatter trap pairing module.

Fig. 1 shows an embodiment of a module 11 for a compton camera. Four modules 11 are shown, but additional or fewer modules may be used. The compton camera is formed of one or more modules, depending on the desired design of the compton camera.

Compton cameras are used for medical imaging. A space for the patient relative to the module is provided such that the module is positioned to detect photons emitted from the patient. The radiopharmaceutical in the patient includes a radioisotope. Photons are emitted from the patient as a result of the decay of the radioisotope. The energy from the radioisotope may be 100-3000keV, depending on the material and structure of the detector. Any of a variety of radioisotopes may be used to image a patient.

Each module 11 includes the same or many identical components. Scatter detector 12, trap detector 13, circuit board 14 and baffle 15 are disposed in the same housing 21. Additional, different or fewer components may be provided. For example, scatter detector 12 and trap detector 13 are disposed in housing 21 without other components. As another example, fiber optic data lines 16 are provided in all or a subset of the modules 11.

The modules 11 are shaped for stacking together. The modules 11 mate with each other, for example with matching recesses and extensions, latches, tongue and groove, or clips. In other embodiments, flat or other surfaces are provided for abutting each other or against the divider. Latches, clips, bolts, tongue and groove or other attachment mechanisms are provided for attaching the module 11 to any adjacent module 11. In other embodiments, the modules 11 are attached to a rack or other frame with or without direct connection to any adjacent modules 11.

The connection to other modules 11 or stands may be releasable. The module 11 is connected and can be disconnected. The connection may be releasable, allowing removal of one module 11 or a group of modules 11 without removing all modules 11.

In order to form a compton camera from more than one module 11, the housing 21 and/or the outer shape of the module 11 is wedge-shaped. Due to the wedge shape, the modules 11 may be stacked around the shaft to form a ring or partial ring. The portions closer to the axis have a narrower width dimension along a dimension perpendicular to the axis than the width dimension of the portions further away from the axis. In the module 11 of fig. 1, the housing 21 has the widest portion furthest from the axis. In other embodiments, the widest portion is closer to the shaft, but spaced from the narrowest portion that is closest to the shaft. In the wedge shape, scatter detector 12 is closer to the narrower portion of the wedge than trap detector 13. The wedge shape in cross section along a plane normal to the shaft allows the modules 11 to be adjacently stacked and/or connected in an abutting position to form at least a portion of a ring around the shaft.

The taper of the wedge provides a number N of modules 11 to form a complete ring around the shaft. Any number N may be used, e.g., N =10-30 modules. The number N may be configurable, for example using different housings 21 for different numbers N. The number of modules 11 for a given compton camera may vary depending on the design of the compton camera (e.g., the partial ring). The wedge shape may be arranged along other dimensions, for example having a wedge shape in a cross section parallel to the axis.

The stacked modules 11 are cylindrically symmetric, such as in connection with a gantry of a medical imaging system. The narrowest end of the wedge-shaped cross-section is closest to a patient space of the medical imaging system, and the widest end of the wedge-shaped cross-section may be furthest from the patient space. In alternative embodiments, other shapes than wedges may be provided that allow stacking together to provide a ring or generally curved shaped stack.

The housing 21 is of metal, plastic, fiberglass, carbon (e.g., carbon fiber), and/or other material. In one embodiment, different portions of the housing 21 are of different materials. For example, tin is used for the housing around the circuit board 14. Aluminum is used to hold scatter detector 12 and/or trap detector 13. In another example, the housing 12 is of the same material, such as aluminum.

The housing 21 may be formed of different structures, such as end plates having a wedge shape, ground plane sheets that house the circuit board 14, and separate structures for holding the walls of the scatter detector 12 and the trap detector 13, wherein the separate structures are formed of a material (e.g., aluminum or carbon fiber) through which photons of the desired energy from a compton event can pass. In an alternative embodiment, no walls are provided for modules 11 between the end plates for the areas where scatter detectors 12 and/or trap detectors 13 are placed, thereby avoiding the transfer of interfering photons from scatter detectors 12 of one module 11 to trap detectors 13 of another module 11. The housing 21 beside the detectors 12, 13 and/or for holding the detectors 12, 13 is made of a low attenuation material, such as aluminum or carbon fiber.

The housing 21 may enclose the module or include an opening. For example, openings for airflow are provided, such as at the top of the widest portion of the wedge at the circuit board 14. The housing 21 may include holes, slots, tabs, latches, clips, seats, bumpers, or other structures for mounting, mating, and/or stacking.

Each solid state detector module 11 includes both a scatter detector 12 and a trap detector 13 of the compton sensor. By stacking each module, the size of the compton sensor is increased. A given module 11 may itself be a compton sensor, since both scatter detector 12 and trap detector 13 are included in the module.

The module 11 may be separately removed and/or added to the compton sensor. For a given module 11, scatter detector 12 and/or trap detector 13 may be removable from module 11. For example, the module 11 is removed for service. The faulty detector or detectors 12, 13 are removed from the module 11 for replacement. Once replaced, the refurbished module 11 is placed back into the medical imaging system. Bolts, clips, latches, tongue and groove, or other releasable connectors may connect the detectors 12, 13 or a portion of the housing 21 for the detectors 12, 13 to the rest of the module 11.

Scatter detector 12 is a solid state detector. Any material may be used, such as Si, CZT, CdTe, HPGe, and/or other materials. Scatter detector 12 is created by wafer fabrication at any thickness, for example about 4 mm for CZT. Any size, for example about 5 x 5 cm, may be used. Fig. 2 shows a square shape for scatter detector 12. Other shapes than square, such as rectangular, may also be used. For module 11 of fig. 1, scatter detector 12 may be rectangular in shape extending between two wedge-shaped end plates.

In module 11, scatter detector 12 has any range. For example, scatter detectors 12 extend from one wedge-shaped end wall to the other. A smaller or larger extent may be provided, for example extending between mounts within the module 11, or axially beyond one or both end walls. In one embodiment, scatter detector 12 is at, on, or beside one end wall, and does not extend to the other end wall.

Scatter detectors 12 form a sensor array. For example, the 5 × 5 cm scatter detector 12 of fig. 2 is a 21 × 21 pixel array having a pixel pitch of about 2.2 mm. Other numbers of pixels, pixel pitches, and/or array sizes may be used.

Scatter detector 12 includes a semiconductor formatted for processing. For example, scatter detector 12 includes an Application Specific Integrated Circuit (ASIC) for sensing photon and electron interactions in scatter detector 12. The ASIC is collocated with pixels of scatter detector 12 (colocate). The ASIC may have any thickness. Multiple ASICs may be provided, for example 9 in a 3 x 3 grid of scatter detectors 12.

Scatter detector 12 may operate at any count rate, for example >100 kcps/mm. Due to the interaction, electricity is generated by the pixels. The electricity is sensed by an application specific integrated circuit. Position, time and/or energy are sensed. The sensed signal may be conditioned (e.g., amplified) and transmitted to one or more circuit boards 14. A flex circuit, wire or other communication path carries the signal from the ASIC to the circuit board 14.

Compton sensing operates without collimation. Instead, the angle of a photon entering scatter detector 12 is determined using a fixed relationship between the energy, location, and angle of photon interaction at scatter detector 12 relative to photon interaction at trap detector 13. The compton process is applied using a scatter detector 12 and a trap detector 13.

The trap detector 13 is a solid state detector. Any material may be used, such as Si, CZT, CdTe, HPGe, and/or other materials. The trap detector 13 is formed by wafer fabrication at any thickness, for example about 10 mm for CZT. Any size, for example about 5 x 5 cm, may be used. This dimension may be larger in at least one dimension than scatter detector 12 due to the wedge shape and the spaced apart position of scatter detector 12 and trap detector 13. Fig. 3 shows a rectangular shape of the trap detector 13, but other shapes may be used. For module 11 of fig. 1, trap detector 13 may be a rectangle extending between two end plates, wherein the length is the same as scatter detector 12 and the width is larger than scatter detector 12.

The trap detector 12 forms a sensor array. For example, the 5 × 6 cm trap detector 13 of fig. 3 is a 14 × 18 pixel array with a pixel pitch of about 3.4 mm. The pixel size is larger than the pixel size of scatter detector 12. The number of pixels is smaller than the number of pixels of scatter detector 12. Other numbers of pixels, pixel pitches, and/or array sizes may be used. Other relative pixel sizes and/or numbers of pixels may be used.

In module 11, the trap detector 13 has any range. For example, the trap detector 13 extends from one wedge-shaped end wall to the other. A smaller or larger extent may be provided, for example extending between mounts within the module 11, or axially beyond one or both end walls. In one embodiment, the trap detector 13 is located at, on or beside one end wall, without extending to the other end wall.

The trap detector 13 comprises a semiconductor formatted for processing. For example, trap detector 13 includes an ASIC for sensing the interaction of photons and electrons in trap detector 13. The ASIC is juxtaposed with the pixels of the trap detector 13. The ASIC may have any thickness. Multiple ASICs may be provided, for example 6 in a 2 x 3 grid of trap detectors 13.

The trap detector 13 may operate at any count rate, for example >100 kcps/mm. Due to the interaction, electricity is generated by the pixels. The electricity is sensed by the ASIC. Position, time and/or energy are sensed. The sensed signal may be conditioned (e.g., amplified) and transmitted to one or more circuit boards 14. A flex circuit, wire or other communication path carries the signal from the ASIC to the circuit board 14.

Trap detector 13 is spaced from scatter detector 12 by any distance along a radial line from the axis or normal to parallel scatter detector 12 and trap detector 13. In one embodiment, the spacing is about 20 cm, but greater or lesser spacing may be provided. The space between trap detector 13 and scatter detector 12 is filled with air, other gases, and/or other materials that have low attenuation for photons at the desired energy.

The circuit board 14 is a printed circuit board, but a flexible circuit or other material may be used. Any number of circuit boards 14 for each module may be used. For example, one circuit board 14 is provided for scatter detector 12 and another circuit board 14 is provided for trap detector 13.

The circuit board 14 is within the housing 21, but may extend outside the housing 21. The housing 21 may be grounded, thereby acting as a ground plane for the circuit board 14. The circuit boards 14 may be mounted parallel to each other or non-parallel, e.g., spread apart in a wedge shape. The circuit board is positioned generally orthogonal to the catcher detector 13. Typically to account for any expansion due to the wedge shape. Brackets, bolts, screws, and/or standoffs with each other and/or with the housing 21 are used to hold the circuit board 14 in place.

Circuit board 14 is connected to the ASICs of scatter detector 12 and drip catcher detector 13 by flex circuits or wires. The ASIC outputs a detection signal. The circuit board 14 is acquisition electronics that processes the detection signals to provide parameters to the compton processor 19. Any parameterization of the detection signal may be used. In one embodiment, energy, time of arrival, and location in three dimensions are output. Other acquisition processes may be provided.

The circuit boards 14 output to each other, to the data bridge 17 and/or to the fiber optic data link 16, for example, through electrical connections within the module 11. The fiber optic data link 16 is a fiber optic interface for converting electrical signals to optical signals. One or more fiber optic cables provide acquisition parameters for the events detected by scatter detector 12 and trap detector 13 to compton processor 19.

Data bridge 17 is a circuit board, wire, flex circuit, and/or other material for electrical connection to allow communication between modules 11. A housing or protective plate may cover the data bridge 17. The data bridge 17 is releasably connected to one or more modules 11. For example, a plug or mating connector of the data bridge 17 mates with a corresponding plug or mating connector on the housing 21 and/or the circuit board 14. Latches, clips, tongue and groove, screws, and/or bolt connections may be used to releasably hold data bridge 17 in place with respect to module 11.

The data bridge 17 allows communication between the modules. For example, the fiber optic data link 16 is disposed in one module 11 but not in another module 11. Avoiding the cost of the fibre optic data link 16 in each module 11. Instead, the parameters output by another module 11 are provided to the module 11 with the fiber optic data link 16 via the data bridge 17. One or more circuit boards 14 of a module 11 having a fiber optic data link 16 route parameter outputs to the fiber optic data link 16, reporting detection events from more than one module 11 using the fiber optic data link 16. In an alternative embodiment, each module 11 includes a fiber optic data link 16, and thus no data bridge 17 is provided or data bridge 17 carries other information.

Data bridge 17 may connect other signals between modules 11. For example, the data bridge 17 includes conductors for power. Alternatively, different bridges provide power to the modules 11, or the modules 11 are individually powered. As another example, a data bridge 17 is used to transfer clock and/or synchronization signals between modules 11.

In the embodiment of fig. 1, a separate clock and/or synchronization bridge 18 is provided. Clock and/or synchronization bridge 18 is a circuit board, wire, flex circuit, and/or other material for electrical connection to allow communication of clock and/or synchronization signals between modules 11. A housing or protective plate may cover the clock and/or synchronization bridge 18. A clock and/or synchronization bridge 18 is releasably connected to one or more modules 11. For example, a plug or mating connector of clock and/or synchronization bridge 18 mates with a corresponding plug or mating connector on housing 21 and/or circuit board 14. Latches, clips, tongue and groove, screws and/or bolt connections may be used to releasably hold the clock and/or synchronization bridge 18 in place with respect to the module 11.

The clock and/or synchronization bridge 18 may be connected to the same or a different set of modules 11 as the data bridge 17. In the embodiment shown in fig. 1, a data bridge 17 is connected between pairs of modules 11 and a clock and/or synchronization bridge 18 is connected over groups of four modules 11.

The clock and/or synchronization bridge 18 provides a common clock signal and/or synchronization signal for synchronizing the clocks of the modules 11. One of the parameters formed by the circuit board 14 of each module 11 is the detection time of the event. Compton detection relies on event pairs (scatter events and trap events). The timing is used to pair events from different detectors 12, 13. The common clock and/or synchronization allows accurate pairing in case event pairs are detected in different modules 11. In an alternative embodiment, only scatter events and trap events detected in the same module 11 are used, and thus the clock and/or synchronization bridge 18 may not be provided.

Other links or bridges between different modules 11 may be provided. Since the bridges 17, 18 are removable, individual modules 11 can be removed for service while leaving the remaining modules 11 in the rack.

Each module 11 is air-cooled. Holes may be provided to force air through the module 11 (i.e., inlet and outlet holes). One or more baffles 15 may be provided to direct air within the module 11. Water, conductive transfer, and/or other cooling may alternatively or additionally be provided.

In one embodiment, the top of the wedge module 11 or housing 21 is open (i.e., there is no cover on the side furthest from the patient area). One or more baffles 15 are disposed along the center of the one or more circuit boards 14 and/or the housing 21. The fan and heat exchanger 20 forces cooling or ambient temperature air into each module 11, for example, half way along the module 11 at a location spaced from the trap detector 13 (e.g., the top of the module 11). Baffle 15 and/or circuit board 14 direct at least some air to the space between scatter detector 12 and trap detector 13. The air then passes over the baffles 15 and/or circuit board 14 on another portion (e.g., the other half) of the module 11 to exit to the heat exchanger 20. Other routes of air may be provided.

The heat exchanger and fan 20 is provided for each individual module 11 and may therefore be wholly or partly within the module 11. In other embodiments, ducts, baffles or other structures direct air to the plurality of modules 11. For example, a group of four modules 11 share a common heat exchanger and fan 20 mounted to a rack or other frame for cooling the group of modules 11.

To form a compton sensor, one or more modules 11 are used. For example, two or more modules 11 are positioned relative to a patient bed or imaging space to detect photon emissions from the patient. The arrangement of a greater number of modules 11 may allow a greater number of emissions to be detected. By using a wedge shape, the modules 11 may be positioned against, adjacent to and/or connected to each other to form an arc around the patient space. The arc may have any range. The modules 11 are in direct contact with each other or through spacers or stands with a small spacing (e.g., 10 cm or less) between the modules 11.

In one example, four modules 11 are positioned together, sharing a clock and/or synchronization bridge 18, one or more data bridges 17, and a heat exchanger and fan 20. One, two or four fibre optic data links 16 are provided for groups of modules 11. Groups of a plurality of such modules 11 may be arranged to be spaced apart or adjacent to each other for the same patient space.

Due to the modular approach, any number of modules 11 may be used. By constructing multiple identical assemblies, manufacturing is more efficient and cost effective, although any given module 11 is used in a different arrangement than for other modules 11.

The fibre optic data link 16 of the module 11 or group of modules 11 is connected to a compton processor 19. The compton processor 19 receives values of parameters for different events. Using energy and timing parameters, scatter events and trap events are paired. For each pair, the spatial location and energy of the event pair are used to find the angle of incidence of the photon on scatter detector 12. In one embodiment, the event pairs are limited to events in the same module 11. In another embodiment, trap events from the same or different modules 11 may be paired with scatter events from a given module 11. More than one compton processor 19 may be used, for example, for pairing events from different parts of the part ring 40.

Once the pair-wise events are linked, the compton processor 19 or another processor may perform computed tomography to reconstruct the distribution in two or three dimensions of the detected emissions. The angle of incidence or line of incidence for each event is used in the reconstruction.

Fig. 4A-6 illustrate one exemplary arrangement of the module 11. The modules 11 form a ring 40 around the patient space. Fig. 4A shows four such rings 40 stacked axially. Fig. 4B shows scatter detectors 12 and corresponding trap detectors 13 of modules 11 in ring 40. Fig. 4C shows a detail of a portion of the ring 40. Three modules 11 provide corresponding pairs of scatter detectors 12 and trap detectors 13. Other dimensions than those shown may be used. Any number of modules 11 may be used to form the ring 40. The ring 40 completely surrounds the patient space. Within the housing of the medical imaging system, the ring 40 is connected to a gantry 50 or another frame, as shown in FIG. 5. The ring 40 may be positioned to allow the patient bed 60 to move the patient into the ring 40 and/or through the ring 40. Fig. 6 shows an example of this configuration.

The ring may be used for compton-based imaging of emissions from a patient. Fig. 7 shows an example using the same type of module 11 but in a different configuration. Forming part of the ring 40. One or more gaps 70 are provided in the ring 40. This may allow for the use of other components in the gap and/or a less expensive system to be manufactured by using fewer modules 11.

Fig. 8 shows another configuration of the module 11. The ring 40 is a complete ring. Additional partial rings 80 are stacked axially relative to the couch 60 or patient space, extending the axial extent of the detected emissions. Instead of the two gaps 70 of fig. 7, the partial ring 80 is distributed with every other or group of N modules 11 (e.g., N = 4). The additional ring may be a complete ring. The complete ring 40 may be a partial ring 80. The different rings 40 and/or partial rings 80 are axially stacked with little or no (e.g., 1/2 less than the axial extent of the module 11) separation. Wider spacing may be provided, for example with a gap greater than the axial extent of one module 11.

Fig. 9 shows yet another configuration of the module 11. One module 11 or a single group of modules 11 is located beside the patient space or bed 60. A plurality of spaced apart individual modules 11 or groups (e.g., groups of four) may be disposed at different locations relative to the couch 60 and/or the patient space.

In either configuration, the module 11 is held in place by attachment to a rack, multiple racks, and/or other frame. The retention is releasable, for example using bolts or screws. A desired number of modules 11 are used to assemble a desired configuration for a given medical imaging system. The aggregated module 11 is installed in the medical imaging system, defining or relative to the patient space. The result is a compton sensor for imaging a patient.

The couch 60 may move the patient to scan different portions of the patient at different times. Alternatively or additionally, the gantry 50 moves the module 11 forming the compton sensor. The gantry 50 translates axially along the patient space and/or rotates the compton sensor around the patient space (i.e., rotates around the long axis of the couch 60 and/or the patient). Other rotations and/or translations may be provided, such as rotating the module 11 about an axis that is not parallel to the long axis of the couch 60 or patient. Combinations of different translations and/or rotations may be provided.

A medical imaging system with a compton sensor is used as a stand-alone imaging system. Compton sensing is used to measure the distribution of a radiopharmaceutical in a patient. For example, a full ring 40, partial ring 40, and/or axially stacked rings 40, 80 are used as a compton-based imaging system.

In other embodiments, the medical imaging system is a multi-modality imaging system. The compton sensor formed by the modules 11 is one modality and another modality is also provided. For example, another modality is a Single Photon Emission Computed Tomography (SPECT), PET, CT, or MR imaging system. The complete ring 40, partial ring 40, axially stacked rings 40, 80 and/or individual modules 11 or groups of modules 11 are combined with sensors for other types of medical imaging. The compton sensor may share the bed 60 with other modalities, such as being positioned along the long axis of the bed 60, wherein the bed positions the patient in one direction in the compton sensor and in the other modality along the other direction.

The compton sensor may share an external housing with other modalities. For example, the full ring 40, partial ring 40, axially stacked rings 40, 80, and/or individual modules 11 or groups of modules 11 are arranged within the same imaging system housing for one or more sensors of other modalities. The couch 60 positions the patient within the imaging system housing relative to the desired sensors. The compton sensor may be positioned axially adjacent to other sensors and/or in a gap at the same axial position. In one embodiment, partial ring 40 is used in a computed tomography system. The gantry holding the X-ray source and X-ray detector also holds the modules 11 of the partial ring 40. The X-ray source is in one gap 70 and the detector is in another gap 70. In another embodiment, a single module 11 or sparsely populated modules 11 are connected to the gantry of the SPECT system. The module 11 is placed adjacent to the gamma camera so that the gantry of the gamma camera can move the module 11. Alternatively, a collimator may be located between the module 11 and the patient or between the scatter detector 12 and the trap detector 13, allowing the scatter detector 12 and/or the trap detector 13 of the module 11 to be used for photoelectric event detection for SPECT imaging, instead of or in addition to the detection of compton events.

The module-based segmentation of the compton sensor allows the same design of module 11 to be used in any of the different configurations. Thus, different numbers of modules 11, module locations, and/or configurations of modules 11 may be used for different medical imaging systems. For example, one arrangement is provided for use with one type of CT system, while a different arrangement (e.g., number and/or location of modules 11) is used for a different type of CT system.

The module-based segmentation of the compton sensor allows for more efficient and cost-effective services. Instead of replacing the entire compton sensor, any module 11 may be disconnected and repaired or replaced. The modules 11 may be connected and disconnected separately from each other and/or from the gantry 50. Any bridges are removed and then the module 11 is removed from the medical imaging system, leaving the other modules 11. It is cheaper to replace the individual modules 11. The amount of time of service may be reduced. Individual components of a defective module 11, such as the scatter detector 12 or the trap detector 13, can be easily replaced while leaving the other. The module 11 may be configured to operate with different radioisotopes (i.e., different energies) by using corresponding detectors 12, 13.

Fig. 11-15 show embodiments in which the module 11 optionally includes a physical aperture for SPECT detection using the photoelectric effect. The module may optionally include a scatter detector for compton detection. The module can be used for both compton detection and photo-electric detection. A multi-modality medical imaging system is formed of one or more modules. The arrangement and assembly of the module 11 discussed with respect to fig. 1-9 may be used with a module 11 having a physical aperture.

The segmented detection module 11 may be used to form a geodesic dome multi-layered multi-modal camera. The camera is segmented into modules that house the detection units. Each module 11 is independent and when assembled into a ring, partial ring or other configuration, the modules 11 may communicate with each other. Each module 11 comprises an inner shell-like layer, called scattering layer, and an outer shell-like layer, called catcher layer. In case a plurality of modules 11 is used, the modules may at least partly surround the imaging subject.

Fig. 16 shows an embodiment of a medical imaging system in which the module 11 does not comprise scatter detectors and thus uses a physical aperture and detectors to provide modular creation of a SPECT camera. Fig. 15 shows an embodiment of a medical imaging system in which the module 11 comprises a scatter detector, thus providing a modular creation of a compton camera using scatter detectors. The module 11 of fig. 15 may include a physical aperture and thus operate as both a compton camera and a SPECT camera. Depending on the desired energy to be imaged for any given system, the base module with the trap detector may be fitted with either or both of a scatter detector (e.g., higher energy) or a physical aperture (e.g., lower energy).

Fig. 11 shows the detector structure of one module 11, wherein both the physical aperture 110 and the scatter detector 12 are selected and included in the same module 11. Module 11 includes a scatter detector 12 and a trap detector 13. Scatter detector 12 and/or trap detector 13 are solid state detectors, and thus module 11 is a solid state detector module. A bracket, frame, clip, or other mechanical structure is provided for positioning scatter detector 12 within module 11, with the selection to include scatter detector 12. The position may be at a given distance from the trap detector 13 or may be adjustable at or after assembly. Mechanical structure may be provided for the location of additional trap detectors and/or scatter detectors in module 11 so that the designer of a given imaging system may select the number of trap layers and/or scatter layers to include.

Additional trap or scatter detectors 12, 13 may be provided, such as parallel layered detectors 12, 13 normal to a radial direction from the patient space (e.g., along the axis of rotation in fig. 11). Any emission passing through one trap detector 13 may interact in the other trap detector 13. Similarly, the intermediate detector may operate as scatter detector 12 as a result of emission through initial scatter detector 12. The intermediate detector may have the same structure as scatter detector 12 or trap detector 13, but operate as scatter detector 12 and/or trap detector 13. One of the scatter detectors 12 produces compton scattered photons, which are trapped by a subsequent one of the trap layers 13.

The modules 11 are independent but can be assembled to produce a unit that forms an image based on a multimodal image. The modules 11 allow design freedom of shape to vary the radius of each radial sensing unit, the angular span of one module 11, and/or the axial span. The size and position of the module 11 relative to the patient space may be varied in design as desired, for example by using different housings.

Any of the shapes described with respect to fig. 1-9 may be used. For example, fig. 1 shows a module 11 having four sides in a cross-section orthogonal to the radial direction of the patient space. In one embodiment, the module 11 has three, five, six or more sides in a cross-section orthogonal to the radial direction of the patient space. Fig. 11 shows a six-sided module 11. In case a plurality of modules 11 are to be used together, all modules have the same number of sides. Alternatively, different modules 11 having different numbers of sides are used together, for example a combination of modules 11 having five and six sides.

The three, five or six sided module has a narrower orthogonal cross section closer to the patient space than an orthogonal cross section further away from the patient space, allowing for a geodesic dome. The modules 11 may be positioned to form a spherical or grid ball top. For any given imaging system, a complete dome is not used. Two or more modules 11 may be positioned to form a portion of a geodesic dome. In alternative embodiments, the modules 11 are not shaped for forming a spherical or grid dome, for example the modules 11 of fig. 1 are shaped to form a ring or cylinder.

The module 11 is cylindrically symmetric. The narrowest end of each module 11 is closest to the patient space of the medical imaging system. The widest end of each module 11 is further or furthest from the patient space. Scatter detector 12 is narrower and has a smaller area than trap detector 13.

In case module 11 comprises both a scatter detector 12 and a trap detector 13, compton based imaging may be provided. To detect events using the photoelectric effect of SPECT, a physical aperture 110 is included in the module 11. The physical aperture 110 is a plate or sheet of material. The physical aperture 110 is any material that is opaque to lower energies (e.g., about or less than 140.5 keV), such as lead or tungsten. Any thickness may be used, for example 0.5-5 mm (e.g. 1-3 mm). The thickness is selected to allow all or some of the higher energy emissions or photons (e.g., > 140.5 keV) to pass through for Compton detection.

A physical aperture 110 is positioned between the positions of scatter detector 12 and trap detector 13. Where intermediate detectors are provided, the physical aperture 110 may be between any of the detector layers. The coded aperture may be adjacent to the trap detector 13, for example within 1 cm (for example within 5 mm), or spaced further from the trap detector 13. In an alternative embodiment, the physical aperture 110 is located before the position of the scatter detector 12 (i.e., closer to the patient space).

Brackets, frames, clips, or other mechanical structures are provided for positioning the physical aperture 110 within the module 11, wherein the physical aperture 110 is optionally included. The position may be at a given distance from the trap detector 13 or may be adjustable at or after assembly.

The physical aperture 110 is orthogonal to the radial direction from the patient space and thus parallel to the detectors 12, 13. Alternatively, the physical aperture 110 is not parallel to one or both of the detectors 12, 13, and/or is not orthogonal to a radial direction from the patient space. The radial direction is shown as the axis of rotation in fig. 11.

The physical aperture 110 has the same shape as the detectors 12, 13. For example and as shown in fig. 11, the physical aperture 110 and detectors 12, 13 are six-sided. The physical aperture 110 may have a different peripheral shape than one or both of the detectors 12, 13.

The physical aperture 110 is a coded aperture. A regular or varying pattern of apertures is provided to cast a shadow on the trap detector 13. The apertures may be of the same or different shapes and/or sizes. The apertures are of sufficient size so that emissions from different angles (e.g., 0-40 degrees from normal to the physical aperture 11) can pass through the apertures. When illuminated from a source (e.g. a patient), the encoding in the bore of the aperture causes overlapping shadows on the trap detector 13. The encoding of the shadow may be used as a mask in the reconstruction to deconvolute the image. In an alternative embodiment, the physical aperture 110 is a parallel-hole collimator (e.g., only emissions 0-1 degrees from orthogonal pass through the hole).

To reduce noise, source size, and/or scattering problems, the coded aperture may be a temporally coded aperture. The physical aperture 110 rotates about a central axis (e.g., radial from the patient space). The coding in the shading is shifted or changed for detection at different times. Detection from different positions of the coded aperture 110 relative to the trap detector 13 is used to reduce noise and/or distinguish background emissions from the patient. The time-coded aperture near the trap detector 13 is rotated around the rotation axis to improve the image quality and increase the field of view. In other embodiments, the physical aperture 110 translates instead of or in addition to rotating. The translation shifts the position of the physical aperture 110 within the module 11 relative to the trap detector 13. Other temporal encodings may be used.

In one embodiment, physical aperture 110 is positioned relative to the trap detector to cast a shadow on a central region 112 of trap detector 13, rather than on an outer region 114 of trap detector 13. For example, physical aperture 110 has the same or similar (e.g., within 10%) area as scatter detector 12 and a smaller area than trap detector 13. Photons detected by the trap layer for the compton effect are more likely to be far from the center of the trap detector 13 due to scattering in compton detection. Conversely, photons detected using the photoelectric effect are more likely to be in the central region 112, since scattering is not used for the photoelectric effect. The central region 112 records compton scattered photons as well as photoelectric events that do not interact with the internal detector. Outer region 114 records only or primarily compton scattering events from inner scatter detector 12 or other scatter detectors 12.

The actual structure of the trap detector 13 may be uniform or the same for both the central region 112 and the outer region 114, but may have different pixel sizes, thicknesses, and/or other characteristics for the different regions 112, 114. Based on the type of imaging performed, readings from the trap detector 13 may be limited to one or both of the regions 112, 114. Alternatively, a different configuration is used, or detection over the entire trap detector 13 is used, regardless of the type of imaging. In case the modules 11 are arranged to communicate, either area 112, 114 of another module 11 may be utilized to detect compton events from one module 11.

Image processor 19 is configured to detect the emission with the photoelectric effect using physical aperture 110 and trap detector 13, and to detect the emission with the compton effect using scatter detector 12 and trap detector 13. The detection events output by the circuit board 14 are used by the image processor 19 for SPECT or compton imaging. For SPECT, a coded or time-coded aperture is used without events from the scatter detector 12. The photoelectric effect is used to detect photons having energies at about 140.5keV or less. For compton scattering, scatter detector 12 and trap detector 13 are used without shadowing from physical aperture 110. The compton effect is used to detect photons with energies that are an order of magnitude greater (e.g., 1450 keV or greater). The same module 11 and image processor 19 are used for both photoelectric and compton imaging.

For compton detection, events from scatter detector 12 and trap detector 13 are paired and used to determine the angle of incidence of compton events in one or more modules 11. Photons may first interact in the scattering layer(s) by compton scattering and then in the trap layer by the photoelectric effect. These photons trigger both the scattering layer(s) and the trap layer and deposit their full energy on all layers (multilayer event). Due to scattering, more than half or most of the events detected in trap detector 13 are in outer region 114. Photon interaction events are predominantly (more than half or mostly) detected in outer region 114. The compton reconstruction is used to determine the correct source direction by knowing (estimating) the compton kinematics based on the measured position (x, y, z) and energy (E) of the paired events.

For photodetection (i.e., SPECT imaging), the photoelectric events from the trap detector 13 are counted. The physical aperture 110 of the module 11 and the trap detector 13 are used. The photons can interact only in the trap layer by the photoelectric effect. The low energy photons may not trigger the scattering layer, but deposit all of their energy on the trap layer (single layer event). Since no scattering is used, the photoelectric events are counted from the central region 112 of the trap detector 13 instead of the outer region 114. Events from the outer region 114 may be used as a measure of background.

The time-coded aperture can be rotated about the axis of the module 11 and used to determine the correct source direction. Temporally encoded coded apertures may reduce background (e.g., scatter, higher energy photons emitted by the source, etc.).

The image processor 19 is configured to generate SPECT images. The counts and positions on the trap detector 13 (i.e. indicative of the position of the line of response) are used to reconstruct a two-or three-dimensional representation of the patient. The location of the transmission is indicated. The image processor 19 is configured to generate a compton image from the compton events. A two-dimensional or three-dimensional representation is reconstructed from the compton scattering events and the corresponding estimated angles. For a three-dimensional representation of an object or image space, a two-dimensional image may be rendered three-dimensionally from the representation.

The display 22 is a CRT, LCD, projector, printer or other display. The display 22 is configured to display a SPECT image and/or a compton image. One or more images are stored in the display plane buffer and read out to the display 22. The images may be displayed separately or in combination, for example displaying a compton image that overlaps or is adjacent to the SPECT image.

Fig. 12-16 illustrate a medical imaging system formed of two or more modules 11. The shape of the solid state detector modules 11 allows the modules 11 to be stacked together, with or without direct contact, to form a portion of a geodesic dome. The modules 11 may be combined to form a 3D mesh dome SPECT-compton camera. Fig. 12-16 show different implementations of the same concept with 18, 34, 54, 3 and 3 modules, respectively.

Fig. 12 shows a module 11 for forming a complete ring 120. Based on the radius of the ring and the size of the modules 11, eighteen modules 11 form a complete ring 120. More or fewer modules 11 may be used to form the complete ring 120. One or more partial rings may alternatively be formed.

Fig. 13 shows a module 11 for forming two complete rings 130, 132. The two rings 130, 132 intersect, thus sharing two modules 134. One of the rings 130 is at 90 degrees to the other ring 132. Other angles may be provided depending on the number and/or shape of the sides of the module 134. In the example of fig. 13, thirty-four modules 11 form two rings 130, 132. Other numbers of modules 11 may be used. One or both of the rings 130, 132 may be partial rings. The rings 130, 132 are separate but intersect. In other embodiments, the rings 130, 132 do not intersect and are spaced apart from each other in parallel or non-parallel planes. Additional rings may be included.

The rings 130, 132 remain in place or stationary. In other embodiments, the rings 130, 132 are connected to a hinge or rotating shaft. The rings 130, 132 pivot (pivot) about a common axis, such as through the axis of two shared modules 134. Independent translation and/or rotation of the two rings 130, 132 or each ring 130, 132 may be provided.

Figure 14 shows a module 11 for forming three rings as part of a larger geodesic dome 140 than figures 12 and 13. A part of the spherical shell is formed by a segment module 11. The three rings are axially adjacent to each other with little (e.g., less than 1/2 width of module 11) or no spacing. The rings may be in direct contact with each other and/or mounted to the same gantry or frame. Three complete rings are shown, but one or more of the rings may be partial rings. Two, four or more rings may be used. In the example of fig. 14, fifty-four modules 11 are used for three rings, but additional or fewer numbers of modules 11 may be used.

Fig. 15 shows three modules 11 positioned relative to a patient bed 60. One, two, four or more modules 11 may be used. The modules 11 are spaced apart from one another by one or more module widths, but smaller spacing or adjacent placement may be used. The module 11 may be connected to another modality, such as a dedicated SPECT camera. The module 11 is connected to the gantry to allow rotation about and/or translation along the patient (e.g., trans axis). Alternatively or additionally, the bed 60 moves the patient relative to the module 11.

Fig. 16 shows the three-module arrangement of fig. 15 using a different type of module 160. Scatter detectors 12 are removed, allowing module 160 to have a lower height or smaller extent along a radial direction from the patient space. The same height may be used, for example, using the same housing, but without scatter detectors 12. Compton imaging is not provided and therefore the module 160 uses the physical aperture 110 with one or more trap detectors 13. The trap detector 13 is used with a time-coded aperture 110 for SPECT or photoelectric effect based imaging. The trap detector 13 absorbs photons by the photoelectric effect. The temporally encoded coded aperture 110 near the catcher layer may be rotated about the rotation axis to improve image quality. The coded aperture may also be moved in the XY detector plane (sideways) to increase the field of view. Other arrangements of the module 160 for SPECT imaging, such as the arrangements of fig. 12-14, may be used. A single module 160 may be used. Fewer or more modules constructed in any of various configurations may be used.

FIG. 10 illustrates one embodiment of a flow chart for a method of creating, using, and repairing a camera that may alternatively be a Compton camera, a SPECT camera, or both. The cameras are formed in a segmented approach. Rather than manually assembling the entire camera in place, one or more of the trap detectors are positioned relative to each other to form the desired configuration of the camera. The trap detector is arranged to be available for relatively low emission energy in the case of coded apertures and for relatively high emission energy in the case of scatter detectors. This alternative and segmented approach may allow for different configurations of the same part to be used, ease of assembly, ease of repair, and/or integration with other imaging modalities.

Other embodiments form a combination of a compton camera and a SPECT camera, where both the scatter detector and the coded aperture are selected for use in the same camera with the trap detector. The segmentation module 11 of fig. 11 is used. The module 160 of fig. 16 may be used to form a SPECT camera without including a scatter detector. The module 11 of fig. 11 can be used to form a compton camera without a coded aperture.

The method may be implemented by the system of fig. 1 to assemble a compton sensor as shown in any of fig. 4-9. The method may be implemented by the system of fig. 11 to assemble a compton sensor as shown in any of fig. 12-16. Other systems, modules and/or configurations of compton sensors may be used.

The actions are performed in the order shown (i.e., top to bottom or numerically) or in other orders. For example, act 108 may be performed as part of act 104.

Additional, different, or fewer acts may be provided. For example, acts 102 and 104 are provided for assembling a Compton camera without performing acts 106 and 108. As another example, act 106 is performed without performing other acts.

In act 102, the trap detector is housed in a separate housing. Modules are assembled, wherein each module includes a trap detector. The machine and/or human creates the housing. Only one housing and corresponding module may be used.

The module is shaped to abut scatter and trap detector pairs of different housings in a non-planar position. For example, a wedge shape and/or positioning is provided such that the detector pair forms an arc, as shown in FIG. 4C. This shape allows and/or forces an arc when the modules are positioned against each other.

For a compton-SPECT camera (e.g., fig. 11), the scatter detector, the coded aperture, and the trap detector are housed in a housing. The housing and the corresponding module have any shape, for example are shaped as or form part of a geodesic dome. The housing optionally includes one or both of a scatter detector and a coded aperture. Depending on design and/or emission energy requirements, the same housing with locations for both the scatter detector and the coded aperture may be used even where only one of the scatter detector or the coded aperture is located or mounted. Alternatively, different housings are used depending on which of the scatter detectors and/or the coded apertures are to be included.

In act 104, the shells are abutted. A person or machine assembles the compton sensor from the housing. By stacking the shells adjacent to each other in direct contact or in contact through spacers, stands or frames, the adjoining shells form an arc. A complete ring or partial ring is formed around and at least partially defines the patient space. Based on the design of the compton, SPECT, or compton-SPECT cameras, any number of housings with corresponding scatter and trap detector pairs are positioned together to form a camera. A single housing may be used.

The housing may abut as part of a multi-modality system or form a single imaging system. For multi-modality systems, the housing is located in the same external housing and/or relative to the same bed as the sensors for the other modalities (e.g., SPECT, PET, CT, or MR imaging systems). The same or different gantry or support frame may be used for the housing of the compton camera and for the sensors of other modalities. For the embodiments of fig. 11-15, the module provides multi-modality by providing both a compton camera and a SPECT imaging system.

The configuration or design of the compton camera defines the number and/or location of the housings. Once abutted, the housing may be connected for communication, such as through one or more bridges. The housing may be connected to other components, such as an air cooling system and/or a compton processor.

In act 106, the assembled compton camera detects the emission. A given emitted photon interacts with a scatter detector. The result is that another photon scatters at a particular angle to the incident line of the emitted photon. The secondary photon has a smaller energy. The secondary photons are detected by a trap detector. Based on the energy and timing of both the detected scatter and trap events, the events are paired. The position and energy of the event pairs provide the ray and scatter angle between the detectors. As a result, the incident ray of the emitted photon is determined.

To increase the probability of detecting secondary photons, a trap event from one shell may be paired with a scatter event of another shell. Due to the angle, scatter from one scatter detector may be incident on a pair of trap detectors in the same housing or on a trap detector in another housing. By opening the housing in the detector area and/or using low photon attenuation materials, a greater number of compton events can be detected.

The detected events are counted or collected. The lines of response or along which different compton events occur are used in the reconstruction. The distribution in three dimensions of the emissions from the patient can be reconstructed based on compton sensing. The reconstruction does not require a collimator because the compton sensing accounts for or provides the angle of incidence of the emitted photons.

Using the compton-SPECT module 11 of fig. 11, the module can also be used to detect emissions as photoelectric events. The lower energy emission passes through the scatter detector. These emissions may pass through holes in the coded aperture or be blocked by the coded aperture. The trap detector detects at least some of the emissions passing through the pores of the coded aperture. Emissions at relatively lower and/or higher energies are detected depending on the selection including either or both of the scatter detector and the coded aperture.

The detected events are used to reconstruct the position of the radioisotope. Compton and/or photoelectric images are generated from the detected events and corresponding line information from the events.

In act 108, a human or machine (e.g., a robot) removes one of the shells. The housing may be removed when one of its detectors or associated electronics fails or is to be replaced for detection at a different energy. The other housing remains in the medical imaging system. This allows for easier repair and/or replacement of the housing and/or detector without the cost of greater disassembly and/or replacement of the entire compton camera.

Although the invention has been described above with reference to various embodiments, it should be understood that many changes and modifications may be made without departing from the scope of the invention. It is therefore intended that the foregoing detailed description be regarded as illustrative rather than limiting, and that it be understood that it is the following claims, including all equivalents, that are intended to define the spirit and scope of this invention.