阅读说明：本技术 具有表现出碎裂的电描记图的区域的心腔的传播标测图 (Propagation map of cardiac chamber with region of electrogram exhibiting fragmentation ) 是由 L·博泽尔 E·拉夫纳 N·多弗 G·韦克塞尔曼 S·里弗龙 于 2021-04-01 设计创作，主要内容包括：本发明题为“具有表现出碎裂的电描记图的区域的心腔的传播标测图”。本发明提供了一种方法,该方法包括存储心脏的表面的至少一部分的解剖标测图。存储在该心脏的该表面上的相应位置处测量的相应电描记图(EGM)信号振幅。基于该EGM信号振幅来限定该表面的其中该EGM信号振幅为碎裂的一个或多个第一区域以及该表面的其中该EGM信号振幅为非碎裂的一个或多个第二区域。在该第一区域中针对该碎裂的EGM信号振幅生成第一表面表示。在该第二区域中从该非碎裂的EGM信号振幅提取传播时间并导出该传播时间的第二表面表示。同时呈现叠加在该解剖标测图上的、该表面的该相应的第一区域和第二区域的该第一表面表示和该第二表面表示。(The invention is entitled "propagation map of cardiac chambers with regions of electrograms exhibiting fragmentation". The invention provides a method comprising storing an anatomical map of at least a portion of a surface of a heart. Respective Electrogram (EGM) signal amplitudes measured at respective locations on the surface of the heart are stored. One or more first regions of the surface in which the EGM signal amplitude is fragmented and one or more second regions of the surface in which the EGM signal amplitude is non-fragmented are defined based on the EGM signal amplitude. A first surface representation is generated for the fragmented EGM signal amplitudes in the first region. A travel time is extracted from the non-fragmented EGM signal amplitude in the second region and a second surface representation of the travel time is derived. Simultaneously presenting the first and second surface representations of the respective first and second regions of the surface superimposed on the anatomical map.)

1. A method for characterizing cardiac arrhythmias, the method comprising:

storing an anatomical map of at least a portion of a surface of a heart;

storing respective Electrogram (EGM) signal amplitudes measured at respective locations on the surface of the heart;

defining one or more first regions of the surface in which the EGM signal amplitude is fragmented and one or more second regions of the surface in which the EGM signal amplitude is non-fragmented based on the EGM signal amplitude;

generating a first surface representation for the fragmented EGM signal amplitudes in the first region;

extracting a travel time from non-fragmented EGM signal amplitudes in the second region and deriving a second surface representation of the travel time; and

simultaneously presenting the first and second surface representations of respective first and second regions of the surface superimposed on the anatomical map.

2. A method according to claim 1, and comprising generating a third surface representation for signals that are neither defined as fragmented nor defined in terms of travel time.

3. The method of claim 1, wherein generating the first surface representation for the fragmented EGM signal amplitudes comprises selecting a subset of the fragmented EGM signal amplitudes and generating the surface for the subset.

4. The method of claim 1, wherein the first surface representation comprises a geometric shape protruding from the surface.

5. The method of claim 2, wherein the geometry of the protrusions comprises one of corrugations and strips.

6. The method of claim 1, wherein the second surface representation comprises a color scale.

7. The method of claim 1, wherein the propagation time comprises a Local Activation Time (LAT) value.

8. The method of claim 1, and comprising assigning a Local Activation Time (LAT) value to an EGM signal even if the EGM signal is fragmented, and generating a third surface representation for the fragmented EGM signal to visualize the third surface representation.

9. The method of claim 1, wherein the propagation time comprises a period length value.

10. A system for characterizing cardiac arrhythmias, the system comprising:

a memory configured to:

storing an anatomical map of at least a portion of a surface of a heart; and

storing respective Electrogram (EGM) signal amplitudes measured at respective locations on the surface of the heart; and

a processor configured to:

defining one or more first regions of the surface in which the EGM signal amplitude is fragmented and one or more second regions of the surface in which the EGM signal amplitude is non-fragmented based on the EGM signal amplitude;

generating a first surface representation for the fragmented EGM signal amplitudes in the first region;

extracting a travel time from non-fragmented EGM signal amplitudes in the second region and deriving a second surface representation of the travel time; and

simultaneously presenting the first and second surface representations of respective first and second regions of the surface superimposed on the anatomical map.

11. The system of claim 10, wherein the processor is further configured to generate a third surface representation for signals that are neither constrained to be fragmented nor constrained by travel time.

12. The system of claim 10, wherein the processor being configured to generate the first surface representation for the fragmented EGM signal amplitudes comprises selecting a subset of the fragmented EGM signal amplitudes and generating the surface for the subset.

13. The system of claim 10, wherein the first surface representation comprises a geometric shape protruding from the surface.

14. The system of claim 11, wherein the geometry of the protrusions comprises one of corrugations and strips.

15. The system of claim 10, wherein the second surface representation comprises a color scale.

16. The system of claim 10, wherein the propagation time comprises a Local Activation Time (LAT) value.

17. The system of claim 10, wherein the processor is configured to assign a Local Activation Time (LAT) value to an EGM signal even if the EGM signal is fragmented, and generate a third surface representation for the fragmented EGM signal to visualize the third surface representation.

18. The system of claim 10, wherein the propagation time comprises a period length value.

Technical Field

The present invention relates generally to electrophysiology mapping, and in particular to visualization of cardiac electrophysiology maps.

Background

Electrophysiological (EP) cardiac mapping may use visualization methods previously proposed in the patent literature to simplify the interpretation of EP maps. For example, U.S. patent 8,838,216 describes a method of generating a model of the surface of the heart with multiple images representing electrogram voltages for multiple measurement points within the heart. The method comprises the following steps: measuring electrogram voltages at a plurality of points within the heart; generating a first model of a cardiac surface of a heart; generating images representative of each electrogram voltage, each image having features representative of electrogram voltages; and generating another model of the surface of the heart. An image representing the electrogram voltage protrudes from the other model of the heart surface at a point on the other model corresponding to the point at which the electrogram voltage was measured. An apparatus for generating a model of a surface of a heart is also disclosed.

As another example, U.S. patent application publication 2009/0192393 describes software and apparatus that automatically detects and maps the plexus within the area of atrial electrogram (CFAE) of complex fractionated lesions that exist in the heart chamber when atrial fibrillation (AFib) occurs. The electrogram signal is analyzed to count the number of complexes whose amplitudes and peak-to-peak intervals meet certain criteria. Functional maps indicating the spatial distribution of the plexus and the relative number of electrograms of complex fractions are generated for display.

U.S. patent application publication 2014/0005563 describes a method for visualizing electrophysiological information that may include electroanatomical data representing electrical activity over a period of time on an anatomical region within a patient. The interval within the time period is selected in response to a user selection. A visual representation of physiological information for a user-selected interval may be generated by applying at least one analytical method to the electroanatomical data. The visual representation may be spatially superimposed on a graphical representation of an anatomical region within the patient. In one embodiment of the invention, the degree of fragmentation can be displayed spatially as an electrogram map of 3D complex fragmentation. The lowest to highest degree of fragmentation can be visually identified by a color map.

Disclosure of Invention

Embodiments of the present invention provide a method comprising storing an anatomical map of at least a portion of a surface of a heart. Respective Electrogram (EGM) signal amplitudes measured at respective locations on a surface of the heart are stored. Defining based on the EGM signal amplitude: one or more first regions of the surface where EGM signal amplitude is fragmented and one or more second regions of the surface where EGM signal amplitude is non-fragmented. A first surface representation is generated for the fragmented EGM signal amplitudes in the first region. The travel time is extracted from the non-fragmented EGM signal amplitudes in the second region and a second surface representation of the travel time is derived. First and second surface representations of respective first and second regions of the surface superimposed on the anatomical map are presented simultaneously.

In some embodiments, the method further comprises generating a third surface representation for signals that are neither defined as fragmented nor defined in terms of travel time.

In one embodiment, generating the first surface representation for the fragmented EGM signal amplitudes includes selecting a subset of the fragmented EGM signal amplitudes and generating a surface for the subset.

In some embodiments, the first surface representation includes a geometric shape protruding from the surface. In some embodiments, the geometry of the protrusion comprises one of a corrugation and a strip.

In one embodiment, the second surface representation comprises a color scale.

In some embodiments, the propagation time comprises a Local Activation Time (LAT) value.

In one embodiment, the method further comprises assigning a Local Activation Time (LAT) value to the EGM signal even if the EGM signal is fragmented, and generating a third surface representation for the fragmented EGM signal to visualize the third surface representation.

In another embodiment, the propagation time comprises a period length value.

There is also provided, in accordance with another embodiment of the present invention, a system including a memory and a processor. The memory is configured to store an anatomical map of at least a portion of a surface of the heart and to store respective Electrogram (EGM) signal amplitudes measured at respective locations on the surface of the heart. The processor is configured to: (i) defining one or more first regions of the surface in which EGM signal amplitude is fragmented and one or more second regions of the surface in which EGM signal amplitude is non-fragmented based on EGM signal amplitude; (ii) generating a first surface representation for the fragmented EGM signal amplitudes in a first region; (iii) extracting a travel time from the non-fragmented EGM signal amplitudes in a second region and deriving a second surface representation of the travel time; and (iv) simultaneously presenting first and second surface representations of respective first and second regions of the surface superimposed on the anatomical map.

Drawings

The invention will be more fully understood from the following detailed description of embodiments of the invention taken together with the accompanying drawings, in which:

fig. 1 is a schematic illustration of a catheter-based cardiac navigation and Electrophysiological (EP) signal analysis system according to an exemplary embodiment of the present invention;

FIG. 2 is a graph schematically illustrating a well-defined Electrogram (EGM) signal versus a fractionated Electrogram (EGM) signal, according to an exemplary embodiment of the present invention;

fig. 3 is a schematic, pictorial rendering of a hybrid representation EP map superimposed on the cardiac chamber anatomy, in accordance with an exemplary embodiment of the present invention; and is

Fig. 4 is a flow diagram schematically illustrating a method and algorithm for generating the hybrid-representation EP map of fig. 3, according to an exemplary embodiment of the present invention.

Detailed Description

SUMMARY

Arrhythmia is a clinical condition with irregular heartbeat. These arrhythmia disorders include important types such as ventricular tachycardia types, atrial tachycardia types, and fibrillation types.

To characterize a patient's arrhythmia, a catheter-based Electrophysiology (EP) mapping system may be used to generate an EP map of at least a portion of the patient's heart, such as an EP map of a heart cavity. In a typical catheter-based EP mapping procedure, the distal end of a catheter including one or more sensing electrodes is inserted into the heart chamber to sense EP signals. As the physician operating the system moves the distal end within the heart chamber, the EP mapping system acquires EP signals at various locations on the inner surface of the heart chamber and at corresponding locations of the distal end. Based on these acquired signals, a processor of the mapping system generates a desired EP map, such as one that includes Local Activation Times (LATs) superimposed on an anatomical map of the heart chamber.

LAT maps typically include regions that display electrical activity with a normal cycle (e.g., sinus rhythm), regions that display electrical activity with an abnormal rapid cycle (e.g., trochanter), and regions that display electrograms with complex fragmentation in pathological tissue. However, in regions exhibiting primarily sinus rhythm and tachycardia, the period of a normal electrogram, the onset of a fast-period electrogram, and the appearance of a complex fractionated electrogram can be observed over time.

The LAT map may thus indicate the occurrence of abnormal but well-defined propagation characteristics of the EP signal. For example, LAT maps may indicate Reentry Tachycardia (RT) by showing regions where EP activation waves propagate in a closed loop with well-defined but pathological cycle lengths (e.g., the time between successive peaks in an electrogram).

However, in some cases, EP anomalies may be manifested by episodes in which the electrogram is fragmented (e.g., consisting of irregular patterns such as highly rapidly deflected bursts of signal), such that the time that the EP wave passes under the acquisition electrode is not definable (or does not actually occur). In the context of the present invention, the term "fractionated electrogram" refers to an aperiodic electrogram without characteristic cycle times and in some cases even definable peaks for deriving LAT values.

For locations of electrograms exhibiting fragmentation, EP propagation maps based on LAT values or cycle times are practically useless because it is difficult to compute meaningful LAT values from such electrogram signals. In addition, the appearance of fractionated electrograms was found to be clinically significant, and their presentation on EP maps was therefore considered important for accurately assessing potential EP pathologies.

One possible way of integrating fragmented signals in EP maps is to use a time-dependent "ripple" map, in which the instantaneous EP amplitude is shown as a function of time, for example by appearing as a time-varying bar protruding from the heart chamber surface. In such a presentation, the length (height) of each bar indicates the voltage measured at the corresponding location on the surface of the cardiac chamber at a given time. However, applying moire mapping to the entire heart chamber is typically computationally intensive and visually too complex to interpret, and may furthermore compromise the clarity of presentation of other important EP information (e.g., LAT information) as other information may be omitted or obscured in such maps.

To overcome the above challenges, the exemplary embodiments of the present invention described below divide a cardiac chamber map into areas that are fragmented and areas that are not fragmented, and integrate two different types of displays into the map simultaneously. In some exemplary embodiments, a hybrid representation EP map is provided in which well-defined EP propagation characteristics (e.g., LAT values) and fragmented EP signal amplitudes are separately superimposed on the cardiac anatomy using different graphical representations, without either obscuring the other. The process generally follows steps in which a processor performs the following operations:

1. an EP map is generated that includes an anatomical map encoded with one or more first regions of fragmented EP activity and one or more second regions of well-defined EP activity, and different regions on the anatomical structure are delineated using data analysis methods such as deep learning or clustering. One or more first regions and one or more second regions of the surface are defined using a processor and based on an Electrogram (EGM) signal amplitude, as described below. The processor then generates a first surface representation for the fragmented EGM signal amplitudes in the first region, extracts the travel times from the non-fragmented EGM signal amplitudes in the second region, and derives a second surface representation of the travel times. Finally, the processor simultaneously presents first and second surface representations of respective first and second regions of the surface superimposed on the anatomical map.

2. When a user requests to propagate a map, the processor displays a traditional propagation map (such as derived from LAT values, for example) over a non-fragmented region, and simultaneously displays a ripple map over a fragmented region.

Conventional propagation maps consist of moving highlights, tones, colors, or some other visual indication of LAT value propagation according to the points. Generally, each dot has one LAT value, however, some dots may have multiple LAT values, for example, a double potential dot may have two LAT values. If the system is designed to have at most one LAT value on each point, a traditional propagation map highlights each point at most once. If the system is designed to assign multiple LAT values to some points, a traditional propagation map may highlight some points multiple times.

In another exemplary embodiment, the processor generates a third surface representation for signals that are neither defined as fragmented nor defined in terms of travel time, such as to exhibit double potentials.

In yet another exemplary embodiment, the processor selects only a subset of the signals for representation by the first surface representation that are considered to be fragmented.

In some cases, even if a certain EGM signal is fragmented, it may be approximated or otherwise assigned a LAT value. In an exemplary embodiment, the processor is further configured to generate different surface representations of such fragmented EGM signals. In this exemplary embodiment, the fragmented signals may be represented by ripples and/or map representations based on LAT values.

The disclosed hybrid representation EP map is dynamic in nature and is capable of displaying regions exhibiting both time-dependent fractionated and non-fractionated Electrogram (EGM) characteristics, for example, in a video mode of the hybrid map.

By displaying fragmented and non-fragmented EGM signatures using different graphical modalities (e.g., corrugations and color patches) on the cardiac anatomy, the disclosed hybrid representation EP mapping technique may improve the diagnostic value of catheter-based EP mapping procedures.

Description of the System

Fig. 1 is a schematic illustration of a catheter-based cardiac navigation and Electrophysiological (EP) signal analysis system 20 according to an exemplary embodiment of the present invention. The system 20 may be configured to analyze substantially any physiological parameter or combination of such parameters. In the description herein, by way of example, the analyzed signals are assumed to be intracardiac Electrograms (EGMs) and/or extracardiac (body surface) Electrocardiographic (ECG) potential-time relationships. To adequately characterize such relationships, the signals at the various locations need to be referenced to one another in time, such as done during Local Activation Time (LAT) map generation. Temporal referencing is accomplished by measuring relative to a reference time (e.g., time of day), such as the beginning of each QRS complex (i.e., the beginning of each heartbeat) of an ECG reference signal. In an exemplary embodiment, the reference signal is received from a catheter placed in the coronary sinus. One method for generating LAT maps is described in U.S. patent 9,050,011, the disclosure of which is incorporated herein by reference in its entirety.

For the sake of brevity and clarity, the following description assumes a study protocol in which system 20 measures actual electrical activity of heart 34 using probe 24, unless otherwise indicated. The distal end 32 of the probe is assumed to have an electrode 22. In other uses, the measured signals are used to create a LAT map of at least a portion of wall tissue of the heart 34 of the patient 26.

Typically, probe 24 comprises a catheter that is inserted into patient 26 during a mapping procedure performed by physician 28 using system 20. During this procedure, the ground electrode 23 is assumed to be attached to the patient 26. Furthermore, it is assumed that the electrode 29 is attached to the skin of the patient 26 in the region of the heart 34.

In an exemplary embodiment, probe 24 acquires EGMs as it moves over a portion of the heart chamber. Some of the features in the measured EGM trace are noted when an abnormal EP activation wave passes under the catheter electrode. In these cases, the position of the probe 24 is also recorded.

System 20 may be controlled by a system processor 40 that includes a processing unit 42 in communication with a memory 44. In some embodiments, the memory 44 included in the system processor 40 stores LAT and/or voltage maps 62 of at least a portion of wall tissue of the heart 34 of the patient 26. The processor 40 is typically mounted in a console 46 that includes operating controls 38, typically including a pointing device 39, such as a mouse or trackball, by which the physician 28 interacts with the processor.

Processor 40 (specifically, processing unit 42) runs software including probe tracker module 30, ECG module 36, and EP activation analysis module 35 to operate system 20 and/or cause EP activation analysis module 35 to run at least a portion of the disclosed analysis (using, for example, LAT or adjusted LAT map 62 stored in memory 44) in order to model arrhythmia.

ECG module 36 is coupled to receive the actual electrical signals from electrodes 22 and electrodes 29. The module is configured to analyze the actual signal and may present the results of the analysis on the display 48 in a standard ECG format, typically a graphical representation that moves over time.

The probe tracker module 30 generally tracks the position of a distal end 32 of the probe 24 within a heart 34 of the patient 26. The tracker module 30 may use any method known in the art for position tracking probes. For example, module 30 may operate a magnetic field-based position tracking subsystem. For the sake of brevity, the components of such subsystems are not shown in fig. 1.

Alternatively or in addition, tracker module 30 may track probe 24 by measuring the impedance between electrode 23, electrode 29 and electrode 22, as well as the impedance to other electrodes that may be located on the probe. In this case, electrode 22 and/or electrode 29 may provide both ECG and position tracking signals. Produced by Biosense-Webster (Irvine, California)The system uses both magnetic field position tracking and impedance measurements for position tracking.

Using the tracker module 30, the processor 40 is able to measure the position of the distal end 32. Further, using both the tracker module 30 and the ECG module 36, the processor is able to measure the position of the distal tip, as well as the LAT of the actual electrical signal detected at these particular locations. As described above, the electrical tracking signals from the individual electrodes 22 may be integrated with the magnetic tracking signals such that the position of each electrode is recorded. Such combined (i.e., magnetic/electric) tracking systems and methods are useful in a variety of medical applications (e.g., in CARTO manufactured by Biosense-Webster Inc^TMSystems) and is described in detail in U.S. patent 8,456,182, the disclosure of which is incorporated herein by reference.

The results of the operations performed by processor 40 are presented to physician 28 on display 48, which typically presents a graphical user interface to the physician, a visual representation of the ECG signals sensed by electrodes 22, and/or an image or map of heart 34 being studied.

For example, software executed by the processor 40 may be downloaded to the processor 40 in electronic form over a network, or alternatively or additionally, provided and/or stored on non-transitory tangible media, such as magnetic, optical, or electronic memory. In particular, the processor 40 runs a dedicated algorithm that enables the processor 40 to perform the steps disclosed herein, as described below.

Fractionated Electrogram (EGM) signals

Fig. 2 is a graph schematically illustrating (i) a well-defined Electrogram (EGM) signal 50 versus (ii) a fractionated Electrogram (EGM) signal 55, according to an exemplary embodiment of the invention. As shown, a well-defined EGM signal can define a time period length 52, whereas at cardiac locations showing episodes of fragmentation with an EGM signal, the time period length cannot be defined. The location of the heart showing an EGM signal with such an interruption may be a source of proarrhythmic activity that requires ablation to treat the resulting arrhythmia. However, complicating matters, both cardiac locations that exhibit well-defined cycle lengths and cardiac locations that exhibit episodes of fragmentation of the EGM signal have significant clinical value in diagnosing arrhythmias.

To address this challenge, exemplary embodiments of the disclosed invention provide a graphical technique to present both types of EP information on the same EP map so that a physician can more easily analyze and diagnose complex abnormal heart activity.

Propagation map of cardiac chamber with region of electrogram exhibiting fragmentation

Fig. 3 is a schematic, pictorial, volumetric rendering of a hybrid representation EP map 60 superimposed on the cardiac chamber anatomy, in accordance with an exemplary embodiment of the present invention. As shown, the hybrid representation EP map 60 includes a first surface representation 61 of a fragmented region and a second surface representation 62 of a non-fragmented (i.e., well-defined) region.

In regions such as region 61 where temporal analysis is not possible due to EGM signals acquired at surface locations of the fragmentation, blended representation EP map 60 provides a visualization of the amplitude of the fragmentation superimposed on the anatomical structure in the form of a bar 63 protruding from the surface, where the height of the bar represents the magnitude of the EGM amplitude at that location at a given time.

The second surface representation 62 encodes propagation time values (e.g., LAT values) in the form of a color-scale rendering 64 (shown in grayscale) on a region of the anatomical map, such as region 62, where the color of a surface location gives the LAT value for that location at a given time.

The mixed representation EP map 60 should be understood as a "snapshot" of the time-dependent EP activity, and the mixed representation EP map 60 is typically displayed using video mode.

Fig. 4 is a flow diagram schematically illustrating a method and algorithm for generating the hybrid-representation EP map 60 of fig. 3, according to an exemplary embodiment of the present invention. According to the exemplary embodiment provided, the algorithm performs a process that begins with processor 40 uploading an anatomical map of a heart chamber and EP mapping data (e.g., a set of EGMs from surface locations on the mapped anatomical structure) from memory 44 at an anatomical structure and EP data uploading step 70.

Next, at EGM analysis step 72, processor 40 determines which EGMs of the uploaded EGMs are fragmented and which EGMs are well-defined (e.g., non-fragmented).

At an EP map generation step 74, processor 40 generates an EP map comprising an anatomical map encoded with one or more first regions of fragmented EP activity and one or more second regions of well-defined EP activity, and depicting different regions on the anatomical structure.

At an EP map presentation step 76, processor 40 presents the delineated EP map of step 74 to a user (e.g., physician 28) on display 48. At this point, physician 28 may need more information, such as displaying a propagation map including LAT values or cycle lengths at a propagation map request step 78.

To preserve fragmented EP activity information without obscuring the propagated information, processor 40 derives the above-described hybrid representation EP map 60.

At an EP data analysis step 80, processor 40 extracts signal amplitudes from the fragmented EGM signals and amplitude propagation times, such as LAT values or cycle lengths, from the non-fragmented EGM signals. Finally, at step 82, processor 40 constructs a hybrid representation EP map 60 in which certain portions of the anatomy are overlaid with discrete representations (e.g., raised bars 68) to display fragmented EP activity, while other portions of the anatomy are overlaid with continuous time information of well-defined EP activity (e.g., color patch regions 64).

It will be appreciated that the embodiments described above are cited by way of example, and that the present invention is not limited to what has been particularly shown and described hereinabove. Rather, the scope of the present invention includes both combinations and subcombinations of the various features described hereinabove, as well as variations and modifications thereof which would occur to persons skilled in the art upon reading the foregoing description and which are not disclosed in the prior art. Documents incorporated by reference into this patent application are considered an integral part of the application, except that definitions in this specification should only be considered if any term defined in these incorporated documents conflicts with a definition explicitly or implicitly set forth in this specification.