阅读说明：本技术 眼科超声成像方法、眼科生物量测量增益调整方法、装置 (Ophthalmologic ultrasonic imaging method, ophthalmologic biological quantity measurement gain adjustment method and device ) 是由 黄志业 林穆清 于 2019-08-29 设计创作，主要内容包括：本发明提供一种眼科超声成像方法、生物量测量增益调整方法、装置,包括：向眼球发射超声波；接收自眼球反射的超声回波,获得超声回波信号；根据超声回波信号得到用于反映眼球的多个生物量的测量信号；根据各生物量对应的超声波反射特性,从测量信号中检测出多个波峰,并得到各个波峰的信号幅度；若一个或多个波峰的信号幅度符合增益调整的预设条件,对测量信号进行分段增益调整；以及显示调整后的测量信号。本发明可以根据数据状态自动调整增益至合理范围,从而提高测量结果的准确性,同时减少医生的检查操作。(The invention provides an ophthalmologic ultrasonic imaging method, a biomass measurement gain adjustment method and a device, comprising the following steps: emitting ultrasonic waves to the eyeball; receiving an ultrasonic echo reflected by an eyeball to obtain an ultrasonic echo signal; obtaining a plurality of measuring signals for reflecting the biomass of the eyeball according to the ultrasonic echo signals; detecting a plurality of wave crests from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave crest; if the signal amplitude of one or more wave crests meets the preset condition of gain adjustment, performing segmented gain adjustment on the measurement signal; and displaying the adjusted measurement signal. The invention can automatically adjust the gain to a reasonable range according to the data state, thereby improving the accuracy of the measurement result and simultaneously reducing the examination operation of doctors.)

1. An ophthalmic ultrasound imaging method, comprising:

emitting ultrasonic waves to the eyeball;

receiving an ultrasonic echo reflected by the eyeball to obtain an ultrasonic echo signal;

obtaining measurement signals for reflecting a plurality of biomasses of the eyeball according to the ultrasonic echo signals;

detecting a plurality of wave peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave peak;

if the signal amplitude of one or more wave crests meets the preset condition of gain adjustment, performing segmented gain adjustment on the measurement signal; and

and displaying the adjusted measuring signal.

2. The method of claim 1, wherein performing a piecewise gain adjustment on the measurement signal if the signal amplitude of one or more peaks meets a predetermined condition for gain adjustment comprises:

and determining whether the difference between the signal amplitudes of the wave crests exceeds a set threshold, and performing segmented gain adjustment on the measurement signal when the difference between the signal amplitudes of the wave crests exceeds the set threshold.

3. The method of claim 2, wherein performing a piece-wise gain adjustment on the measurement signal comprises:

and increasing the signal amplitude of the wave peaks with smaller signal amplitude in the wave peaks so that the difference value between the signal amplitudes of the wave peaks does not exceed a set threshold value.

4. The method of claim 1, wherein performing a piecewise gain adjustment on the measurement signal if the signal amplitude of one or more peaks meets a predetermined condition for gain adjustment comprises:

and determining whether the signal amplitude of each peak is lower than a set amplitude, and when the peak with the signal amplitude lower than the set amplitude exists in the measurement signal, performing segmented gain adjustment on the peak lower than the set amplitude in the measurement signal.

5. The method of claim 4, wherein adjusting the gain of the peak in the measurement signal below a set amplitude comprises: increasing the signal amplitude of the peak below the set amplitude to at least not below the set amplitude.

6. A method as claimed in any one of claims 1 to 5, characterized in that after the step gain adjustment of the measurement signal, the measurement signal is processed again in order to retrieve the plurality of peaks and the signal amplitudes of the individual peaks on the basis of the adjusted measurement signal.

7. The method of claim 1, wherein detecting a plurality of peaks from the measurement signal based on the ultrasonic reflection characteristics corresponding to each biomass comprises:

and determining a plurality of time ranges for performing peak detection in the measurement signal according to the reflection time length of the ultrasonic wave corresponding to each biomass, and performing peak signal detection in each time range to determine a plurality of peaks.

8. The method of any one of claims 1-7, wherein the plurality of biomass is selected from the group consisting of: corneal thickness, anterior chamber depth, lens thickness, vitreous length, and ocular axis length.

9. The method according to any one of claims 1-5, wherein deriving measurement signals for reflecting a plurality of biomasses of the eyeball from the ultrasound echo signals comprises:

analog amplification is carried out on the ultrasonic echo signal,

performing analog-to-digital conversion on the ultrasonic echo signal after analog amplification; and

obtaining the measuring signal according to the ultrasonic echo signal after analog-to-digital conversion;

the method further comprises the following steps: and when the signal intensity of the ultrasonic echo signal after analog amplification is determined to exceed the conversion threshold value of analog-to-digital conversion, adjusting the analog gain for analog amplification of the ultrasonic echo signal.

10. The method of claim 9, wherein adjusting the analog gain comprises adjusting a gain value of a portion or an entirety of an analog gain curve.

11. A method for automatically adjusting ophthalmic biometric gain, comprising:

acquiring measurement signals for reflecting a plurality of biomasses of eyeballs;

detecting a plurality of wave peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave peak; and

and when the signal amplitude of one or more peaks accords with a gain adjustment condition, performing segmented gain adjustment on the measurement signal.

12. The method of claim 11, wherein performing a piecewise gain adjustment on the measurement signal when the signal amplitude of one or more of the peaks meets a gain adjustment condition comprises:

and when the difference between the signal amplitudes of the wave crests exceeds a set threshold value, increasing the signal amplitude of the wave crest with smaller signal amplitude in the wave crests so as to enable the difference between the signal amplitudes of the wave crests not to exceed the set threshold value.

13. The method of claim 11, wherein performing a piecewise gain adjustment on the measurement signal when the signal amplitude of one or more of the peaks meets a gain adjustment condition comprises:

when the signal amplitude of one or more peaks is lower than the peak with set amplitude, the signal amplitude of the peak lower than the set amplitude is increased to be at least not lower than the set amplitude.

14. An ophthalmic ultrasonic imaging apparatus, comprising:

the ultrasonic probe is used for transmitting ultrasonic waves to an eyeball and receiving ultrasonic echoes reflected by the eyeball to obtain ultrasonic echo signals;

a processor to:

obtaining measurement signals for reflecting a plurality of biomasses of the eyeball according to the ultrasonic echo signals;

detecting a plurality of wave peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave peak; and

when the signal amplitude of one or more wave crests is determined to meet the preset condition of gain adjustment, performing segmented gain adjustment on the measurement signal; and

a display for displaying the adjusted measurement signal.

15. The ophthalmic ultrasonic imaging device of claim 14, wherein the processor performs a piecewise gain adjustment on the measurement signal upon determining that the signal amplitude of one or more of the peaks meets a preset condition for gain adjustment, comprising:

and determining whether the difference between the signal amplitudes of the wave crests exceeds a set threshold, and performing segmented gain adjustment on the measurement signal when the difference between the signal amplitudes of the wave crests exceeds the set threshold.

16. The ophthalmic ultrasonic imaging device of claim 15, wherein the processor performs a piecewise gain adjustment on the measurement signal comprising:

and increasing the signal amplitude of the wave peak with smaller signal amplitude in each wave peak so that the difference value between the signal amplitudes of the wave peaks does not exceed the set threshold value.

17. The ophthalmic ultrasonic imaging device of claim 14, wherein the processor performs a piecewise gain adjustment on the measurement signal upon determining that the signal amplitude of one or more of the peaks meets a preset condition for gain adjustment, comprising:

and determining whether the signal amplitude of each peak is lower than a set amplitude, and increasing the signal amplitude of the peak lower than the set amplitude to be at least not lower than the set amplitude when the peak with the signal amplitude lower than the set amplitude exists in the measurement signal.

18. The ophthalmic ultrasonic imaging device of claim 14, wherein the processor detects a plurality of peaks from the measurement signal based on ultrasonic reflection characteristics corresponding to each biomass, comprising:

and determining a plurality of time ranges for performing peak detection in the measurement signal according to the reflection time length of the ultrasonic wave corresponding to each biomass, and performing peak signal detection in each time range to determine a plurality of peaks.

19. The ophthalmic ultrasonic imaging device of any one of claims 14-18, wherein the processor deriving measurement signals for reflecting a plurality of biomasses of the eyeball from the ultrasonic echo signals comprises:

analog amplification is carried out on the ultrasonic echo signal,

performing analog-to-digital conversion on the ultrasonic echo signal after analog amplification; and

obtaining the measuring signal according to the ultrasonic echo signal after analog-to-digital conversion;

the processor is further configured to adjust an analog gain for analog amplification of the ultrasonic echo signal when it is determined that the signal intensity of the analog-amplified ultrasonic echo signal exceeds a conversion threshold of analog-to-digital conversion.

20. An ophthalmologic biometric measurement apparatus, comprising:

one or more processors working together or separately;

a memory storing one or more computer programs that, when executed by the one or more processors, cause the one or more processors to perform:

acquiring measurement signals for reflecting a plurality of biomasses of eyeballs;

detecting a plurality of wave peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave peak; and

and when the signal amplitude of one or more peaks is determined to accord with a gain adjustment condition, performing segmented gain adjustment on the measurement signal.

Technical Field

The invention relates to the technical field of ophthalmologic biomass measurement, in particular to an ophthalmologic ultrasonic imaging method, a method for automatically adjusting ophthalmologic biomass measurement gain, an ophthalmologic ultrasonic imaging device and an ophthalmologic biomass measurement device.

Background

The A-mode ultrasound is also called A-mode ultrasound, and detects the echo condition of a sound wave according to the relation between the time and the amplitude of the sound wave. The principle of the ophthalmologic ultrasonic imaging is that when a probe is placed in front of an eyeball, sound waves are transmitted forwards, and according to the transmission characteristics of the sound waves, reflection occurs once when an interface with density difference meets to form a wave peak, so that reflected echoes are sequentially arranged according to the returning time, the height of the wave peak represents the intensity of the echoes, and the higher the wave peak is, the stronger the echoes are. The a-mode is determined by detecting the position of the peak and calculating the corresponding biomass of the eyeball (e.g., the eye's corneal thickness, anterior chamber depth, lens thickness, vitreous length, and axial length of the eye) by sound velocity matching. However, due to the fact that the sound waves are transmitted in tissues with different densities, the intensity of the echo waves can be different, and therefore the wave peaks of the echo waves are high and even saturated; some echoes have small wave peaks, and no effective data can be detected.

Disclosure of Invention

In one aspect, the present invention provides an ophthalmic ultrasound imaging method, the method comprising:

emitting ultrasonic waves to the eyeball;

receiving an ultrasonic echo reflected by the eyeball to obtain an ultrasonic echo signal;

obtaining measurement signals for reflecting a plurality of biomasses of the eyeball according to the ultrasonic echo signals;

detecting a plurality of wave peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave peak;

if the signal amplitude of one or more wave crests meets the preset condition of gain adjustment, performing segmented gain adjustment on the measurement signal; and

and displaying the adjusted measuring signal.

In another aspect, the present invention provides a method for automatically adjusting an ophthalmic biometric gain, the method comprising:

acquiring measurement signals for reflecting a plurality of biomasses of eyeballs;

detecting a plurality of wave peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave peak; and

and when the signal amplitude of one or more peaks accords with a gain adjustment condition, performing segmented gain adjustment on the measurement signal.

Illustratively, when the signal amplitude of one or more of the peaks meets a gain adjustment condition, performing a piecewise gain adjustment on the measurement signal includes:

and when the difference between the signal amplitudes of the wave crests exceeds a set threshold value, increasing the signal amplitude of the wave crest with smaller signal amplitude in the wave crests so as to enable the difference between the signal amplitudes of the wave crests not to exceed the set threshold value.

Illustratively, when the signal amplitude of one or more of the peaks meets a gain adjustment condition, performing a piecewise gain adjustment on the measurement signal includes:

when the signal amplitude of one or more peaks is lower than the peak with set amplitude, the signal amplitude of the peak lower than the set amplitude is increased to be at least not lower than the set amplitude.

Another aspect of the present invention provides an ophthalmic ultrasonic imaging apparatus, comprising:

the ultrasonic probe is used for transmitting ultrasonic waves to an eyeball and receiving ultrasonic echoes reflected by the eyeball to obtain ultrasonic echo signals;

a processor to:

obtaining measurement signals for reflecting a plurality of biomasses of the eyeball according to the ultrasonic echo signals;

detecting a plurality of wave peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave peak; and

when the signal amplitude of one or more wave crests is determined to meet the preset condition of gain adjustment, performing segmented gain adjustment on the measurement signal; and

a display for displaying the adjusted measurement signal.

Another aspect of the present invention provides an ophthalmologic biometric measurement apparatus, including:

one or more processors working together or separately;

a memory storing one or more computer programs that, when executed by the one or more processors, cause the one or more processors to perform:

acquiring measurement signals for reflecting a plurality of biomasses of eyeballs;

detecting a plurality of wave peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave peak; and

and when the signal amplitude of one or more peaks is determined to accord with a gain adjustment condition, performing segmented gain adjustment on the measurement signal.

According to the ophthalmologic ultrasonic imaging method, the method for automatically adjusting the ophthalmologic biological quantity measurement gain, the ophthalmologic ultrasonic imaging device and the ophthalmologic biological quantity measurement device provided by the embodiment of the invention, when the signal amplitude of one or more wave crests is determined to accord with the gain adjustment condition, the segmented gain adjustment is carried out on the measurement signal, and the signal amplitude of each wave crest is adjusted to be within a reasonable range through the segmented gain adjustment, so that the availability and the accuracy of the measurement result are improved, and the operation of doctor examination is reduced.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive labor.

FIG. 1 shows a schematic structural diagram of an exemplary ophthalmic ultrasound imaging apparatus for implementing the ophthalmic ultrasound imaging method and apparatus of the present invention;

FIG. 2 shows a schematic flow diagram of an ophthalmic ultrasound imaging method according to an embodiment of the invention;

FIGS. 3A and 3B illustrate schematic and schematic diagrams of piecewise gain adjustment in ophthalmic ultrasound imaging according to embodiments of the present invention;

FIG. 4 is a block diagram illustrating a schematic configuration of a processor of an ophthalmic ultrasound imaging apparatus according to an embodiment of the present invention;

FIG. 5 shows a schematic flow diagram of a method for automatically adjusting an ophthalmic biometric measurement gain in accordance with an embodiment of the present invention;

fig. 6 shows a schematic structural block diagram of an ophthalmic biometric measuring apparatus according to an embodiment of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, exemplary embodiments according to the present invention will be described in detail below with reference to the accompanying drawings. It is to be understood that the described embodiments are merely a subset of embodiments of the invention and not all embodiments of the invention, with the understanding that the invention is not limited to the example embodiments described herein. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the invention described herein without inventive step, shall fall within the scope of protection of the invention.

In the following description, numerous specific details are set forth in order to provide a more thorough understanding of the present invention. It will be apparent, however, to one skilled in the art, that the present invention may be practiced without one or more of these specific details. In other instances, well-known features have not been described in order to avoid obscuring the invention.

It is to be understood that the present invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. As used herein, the term "and/or" includes any and all combinations of the associated listed items.

In order to provide a thorough understanding of the present invention, a detailed structure will be set forth in the following description in order to explain the present invention. Alternative embodiments of the invention are described in detail below, however, the invention may be practiced in other embodiments that depart from these specific details.

Referring to fig. 1, fig. 1 shows a schematic structural diagram of an exemplary ophthalmic ultrasonic imaging apparatus 100 for implementing the ophthalmic ultrasonic imaging method and apparatus of the present invention, the ultrasonic imaging apparatus 100 includes an ultrasonic probe 101, a transmitting circuit 102, a receiving circuit 103, a processor 105, and a human-computer interaction device 106, and the transmitting circuit 102 and the receiving circuit 103 can be connected to the ultrasonic probe 101 through a transmitting/receiving selection switch 107.

In ophthalmic ultrasound imaging, the transmit circuit 102 sends a delay-focused transmit pulse having a certain amplitude and polarity to the ultrasound probe 101 through the transmit/receive selection switch 107 to excite the ultrasound probe 101 to transmit an ultrasound wave (e.g., transmit an a-type ultrasound wave) to the eyeball. After a certain time delay, the receiving circuit 103 receives the echo of the ultrasonic wave through the transmitting/receiving selection switch 107 to obtain an ultrasonic echo signal, and performs amplification, analog-to-digital conversion and other processing on the echo signal, and then sends the processed ultrasonic echo signal to the processor 105 to perform peak detection and other related processing to obtain a required a ultrasonic measurement signal, and through the position of each peak on the measurement signal, the biomass of the corresponding eyeball, such as the thickness of the cornea of the eyeball, the anterior chamber depth, the lens thickness, the vitreous body length and the axial length of the eyeball, can be further calculated through methods such as sound velocity matching.

The human-computer interaction device 106 is connected to the processor 105, for example, the processor 105 may be connected to the human-computer interaction device 106 through an external input/output port, and the human-computer interaction device 106 may detect input information of a user, for example, the input information may be a control instruction for the ultrasonic wave transmitting and receiving timing, an operation input instruction for editing and labeling the measurement result of the ophthalmic biomass, or the like, or may further include other instruction types. The human-computer interaction device 106 may include one or more of a keyboard, a mouse, a scroll wheel, a track ball, a mobile input device (such as a mobile device with a touch display screen, a mobile phone, etc.), a multifunctional knob, etc., so that the corresponding external input/output port may be a wireless communication module, a wired communication module, or a combination of the two. The external input/output port may also be implemented based on USB, bus protocols such as CAN, and/or wired network protocols, etc.

The human-computer interaction device 106 also comprises a display which can display the measurement signals obtained by the processor 105. In addition, the display can provide a graphical interface for human-computer interaction for a user while displaying the measurement signal, one or more controlled objects are arranged on the graphical interface, and the user is provided with an operation instruction input by the human-computer interaction device 106 to control the controlled objects, so that corresponding control operation is performed. For example, an icon is displayed on the graphical interface, and the icon can be operated by the human-computer interaction device to execute a specific function, such as a function for marking the measurement result of the ophthalmic biomass. In practice, the display may be a touch screen display. In addition, the display in this embodiment may include one display, or may include a plurality of displays.

In the embodiment of the present invention, the processor 105 is configured to process the ultrasonic echo signal to obtain measurement signals reflecting a plurality of biomasses of the eyeball; the processor 105 is further configured to detect a plurality of peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to each of the plurality of peaks, obtain the signal amplitude and position of each peak, and then calculate a corresponding biomass of the eyeball through sound velocity matching, wherein the biomass includes, for example, an eye cornea thickness, an anterior chamber depth, a lens thickness, a vitreous body length, and an eye axis length of the eyeball, and the eye axis length is equal to the eye cornea thickness + the anterior chamber depth + the lens thickness + the vitreous body length. The human-computer interaction device 106 displays the detection result including the parameter information and the image information calculated by the processor 105 through the display.

FIG. 2 shows a schematic flow diagram of an ophthalmic ultrasound imaging method according to an embodiment of the invention. As shown in fig. 2, the ophthalmic ultrasonic imaging method provided by the present embodiment includes:

step S201, an ultrasonic wave is emitted to the eyeball. For example, by controlling an ultrasonic probe in the ophthalmic ultrasonic imaging apparatus shown in fig. 1 to emit an ultrasonic wave, illustratively, an a-type ultrasonic wave, to the eyeball.

Step S202, receiving the ultrasonic echo reflected by the eyeball to obtain an ultrasonic echo signal.

For example, by switching the ultrasonic probe to the receiving mode, the ultrasonic echo reflected by the eyeball is received, that is, the reflected acoustic signal is converted into an electrical signal by the receiving circuit.

Step S203, obtaining a plurality of measuring signals for reflecting the biomass of the eyeball according to the ultrasonic echo signals.

That is, by processing the ultrasonic echo signal, measurement signals reflecting a plurality of biomasses of the eyeball are obtained.

Illustratively, the plurality of biomass is selected from the group consisting of: corneal thickness, anterior chamber depth, lens thickness, vitreous length, and ocular axis length.

Exemplarily, in the present embodiment, the obtaining of the measurement signals for reflecting the plurality of biomasses of the eyeball from the ultrasound echo signals specifically includes the following steps:

and A1, performing analog amplification on the ultrasonic echo signals. Namely, the received ultrasonic echo signals are amplified to be beneficial to subsequent processing. The gain of the analog amplification may be according to a default setting or according to a preset setting.

And A2, performing analog-to-digital conversion on the analog amplified ultrasonic echo signal. I.e. converting the analog amplified ultrasound echo signal into a digital signal. Illustratively, the implementation is facilitated by a corresponding analog-to-digital conversion circuit or chip.

And A3, obtaining a measuring signal according to the ultrasonic echo signal after the analog-to-digital conversion. That is, the analog-to-digital converted ultrasonic echo signal is processed to obtain measurement signals reflecting a plurality of biomasses of the eyeball, which may be represented as images or graphics, and displayed on a display. For example, the overall gain of the analog-to-digital converted digital signal may be adjusted, and the adjusted signal may be processed to form a measurement signal including a plurality of peaks. In some examples, pre-processing operations such as filtering may be further performed before performing overall gain adjustment to improve the signal-to-noise ratio of the signal.

Due to the analog-to-digital conversion of the receiving circuit/chip or the processing circuit/chip of the general ultrasonic echo signal, a corresponding threshold exists (the analog signal exceeding the threshold is truncated, and the digital signal cannot effectively reflect the size of the analog signal). Therefore, when receiving or processing the ultrasonic echo signal, it is necessary to determine whether the signal strength of the analog-amplified ultrasonic echo signal exceeds a conversion threshold of the analog-to-digital conversion (i.e., whether the amplitude of a part of the signal exceeds the conversion threshold of the analog-to-digital conversion), and adjust the analog gain for analog amplification of the ultrasonic echo signal when determining that the signal strength of the analog-amplified ultrasonic echo signal exceeds the conversion threshold of the analog-to-digital conversion.

For example, in the present embodiment, it may be determined by a corresponding circuit or chip in the ophthalmic ultrasonic imaging apparatus whether the signal intensity of the ultrasonic echo signal after analog amplification exceeds a conversion threshold of analog-to-digital conversion, for example, by a comparison circuit to determine whether the signal intensity of the ultrasonic echo signal after analog amplification exceeds the conversion threshold of analog-to-digital conversion.

For example, in this embodiment, it is further included that whether the amplified signal strength exceeds a conversion threshold of the analog-to-digital conversion is determined by the waveform or the graph of the ultrasonic echo signal, for example, if the waveform or the graph of the ultrasonic echo signal exists for a longer time (which may be determined empirically or through calculation) and is at a threshold size, it indicates that this segment of the signal is a signal formed by clipping in the analog-to-digital conversion process, that is, the signal strength of the amplified ultrasonic echo signal exceeds the conversion threshold of the analog-to-digital conversion.

And when the signal intensity of the ultrasonic echo signal after analog amplification exceeds the conversion threshold value of analog-to-digital conversion, adjusting the analog gain for performing analog amplification on the ultrasonic echo signal. That is, the gain is adjusted during the analog amplification of the ultrasonic echo signal. Illustratively, adjusting the analog gain may be accomplished by adjusting a gain value of a portion or the entirety of the analog gain curve.

The analog gain can be adjusted by directly calculating to obtain a proper analog gain according to the conversion threshold and the signal intensity amplitude of the analog amplified ultrasonic echo signal, and applying the calculated analog gain to an analog amplification link. For the adjustment of the analog gain, a gain adjustment scheme may also be preset in the ophthalmic ultrasonic imaging device, for example, a certain gain value is reduced each time, and then it is determined whether the signal intensity of the ultrasonic echo signal amplified by the gain value will exceed the conversion threshold, and if so, the adjustment and determination processes are repeated until the signal intensity of the ultrasonic echo signal amplified by the analog does not exceed the conversion threshold.

In step S204, a plurality of peaks are detected from the measurement signal according to the ultrasonic reflection characteristics corresponding to each biomass, and the signal amplitude of each peak is obtained.

Illustratively, a plurality of time ranges for performing peak detection in the measurement signal are determined according to the reflection time length of the ultrasonic wave corresponding to each biomass, and peak signal detection is performed in each time range to determine a plurality of peaks. For example, the thickness of the cornea of the eye and the depth of the anterior chamber correspond to a first time range and a second time range, respectively, peak detection is performed in the respective time ranges of the measurement signals, and when a peak is detected in the first time range, the peak is regarded as a peak corresponding to the thickness of the cornea of the eye, and similarly, a peak detected in the second time range is regarded as a peak corresponding to the depth of the anterior chamber. The processor further calculates the biological quantity of the corneal thickness of the eye by combining sound velocity matching according to the position of the peak corresponding to the corneal thickness of the eye; similarly, the amount of organism that gives the anterior chamber depth can be calculated. The wave crest detection is carried out according to the ultrasonic reflection characteristics corresponding to each biomass, the detection efficiency and the detection accuracy can be improved, and the biomass corresponding to the wave crest can be further calculated after the wave crest is detected by combining the characteristics of each biomass. The detection of the peak signal can be obtained by a corresponding detection circuit and graphic processing. When a plurality of peaks are detected, the signal amplitude and position of each peak can be obtained.

In step S205, if the signal amplitudes of one or more peaks meet the preset condition of gain adjustment, the measurement signal is subjected to a piecewise gain adjustment.

Illustratively, the preset condition is whether the difference between the signal amplitudes of the respective peaks exceeds a set threshold, and if it is determined that the difference between the signal amplitudes of the respective peaks exceeds the set threshold, the measurement signal is adjusted in a piecewise gain. For example, when there is a difference between the signal amplitudes of any two peaks exceeding a set threshold, the measurement signal is subjected to a piece-wise gain adjustment. For example, the signal amplitudes of the peaks having smaller signal amplitudes may be increased so that the difference between the signal amplitudes of the peaks does not exceed the set threshold. Namely, the signal amplitudes of the wave crests are close to each other, so that a user can obtain a more accurate measurement result according to the adjusted wave crests.

Illustratively, the preset condition is whether the signal amplitude of each peak is lower than a set amplitude, and if it is determined that a peak with a signal amplitude lower than the set amplitude exists in the measurement signal, the peak lower than the set amplitude in the measurement signal is subjected to a piecewise gain adjustment. Illustratively, the measurement signal may be adjusted in a piecewise gain by increasing the signal amplitude of peaks below a set amplitude to at least not below the set amplitude. I.e. the signal of each peak is brought at least to a set amplitude which can meet the requirements for further calculation of biomass to some extent.

For example, the preset conditions may include whether the signal amplitudes of the respective peaks differ by more than a set threshold and whether the signal amplitudes of the respective peaks are lower than a set amplitude. That is, the judgment of the signal amplitude difference between the peaks is included, and the judgment of whether the signal amplitude of the peak is lower than the set amplitude is also included. Through signal analysis and piecewise gain adjustment in two aspects, the adjusted measurement signal not only has a plurality of similar wave crests, but also the signal of each wave crest meets the requirement of further calculating the biomass.

In this embodiment, the segmented gain adjustment of the measurement signal can be implemented by superimposing a segmented gain adjustment curve on the original measurement signal curve. Fig. 3A and 3B show schematic diagrams of a segmented gain adjustment in ophthalmic ultrasound imaging according to an embodiment of the present invention. As shown in fig. 3A and 3B, a curve 1 in fig. 3A represents a curve without performing the fractional gain adjustment, and the difference between the amplitudes of the first two peaks and the amplitude of the next peak exceeds a set threshold, or the amplitudes of the first two peaks are lower than the set amplitude, which is not favorable for accurately obtaining the peak position, and further affects the accuracy of the measurement result. Therefore, the segmented gain adjustment is required, the curve in fig. 3A is a 2-segmented gain adjustment curve, and the graph obtained after the curve 1 and the curve 2 in fig. 3A are superimposed (i.e., after the segmented gain adjustment) is as shown in fig. 3B, as can be seen from fig. 3B, after the segmented gain adjustment, the original peak with a smaller amplitude is increased, which is more beneficial for the observation of a doctor and the acquisition of the peak position.

Step S206, displaying the adjusted measuring signal.

That is, the measurement signal after gain adjustment is displayed on the display, so as to obtain the position of each peak according to the measurement signal, and accordingly, the detection result, that is, the eyeball biomass is obtained.

Furthermore, it should be understood that in the ophthalmic ultrasonic imaging method of the present embodiment, analog gain adjustment of the ultrasonic echo signal and piecewise gain adjustment of the measurement signal may need to be performed, and the gain adjustment may affect acquisition of subsequent detection results, so that, after the analog gain adjustment of the ultrasonic echo signal and/or the piecewise gain adjustment of the measurement signal are performed, the measurement signal needs to be processed again to obtain multiple peaks and signal amplitudes and positions of the peaks again based on the adjusted measurement signal, and then the biomass of the corresponding eyeball is calculated by sound speed matching according to the positions of the peaks.

According to the ophthalmic ultrasonic imaging method provided by the embodiment of the invention, when the signal amplitude of one or more wave crests is determined to meet the gain adjustment condition, the segmented gain adjustment is carried out on the measurement signal, and the signal amplitude of one or more wave crests is adjusted to be within a reasonable range through the segmented gain adjustment, so that the accuracy of the measurement result is improved, and the automatic completion of the segmented gain adjustment can reduce the operation times of obtaining the measurement signal required by a doctor, reduce the operation of doctor examination and improve the examination efficiency of the doctor.

Fig. 4 is a schematic block diagram of a processor of an ophthalmic ultrasonic imaging apparatus according to an embodiment of the present invention.

As shown in fig. 4, the processor 105 includes an analog amplification module 431, an analog-to-digital conversion module 432, a signal processing module 433, a determination module 434, a gain adjustment module 435, and a detection result acquisition module 436.

The analog amplification module 431 is configured to perform analog amplification on the ultrasonic echo signal received by the ultrasonic probe, so as to facilitate subsequent processing. The gain of the analog amplification may be according to a default setting or according to a preset setting. The analog amplifying module 431 may be implemented as various analog amplifying circuits or chips, and the analog amplifying circuits may be one-stage amplifying circuits or multi-stage amplifying circuits.

The analog-to-digital conversion module 432 is configured to perform analog-to-digital conversion on the ultrasound echo signal that is analog-amplified by the analog amplification module 431. The analog-to-digital conversion module 432 may be implemented as an analog-to-digital conversion circuit or chip.

The signal processing module 433 is configured to obtain a measurement signal according to the ultrasonic echo signal after the analog-to-digital conversion, detect a plurality of peaks from the measurement signal according to the ultrasonic reflection characteristics corresponding to each biomass, and obtain a signal amplitude of each peak. For example, the signal processing module 433 determines a plurality of time ranges for performing peak detection in the measurement signal according to the reflection time length of the ultrasonic wave corresponding to each biomass, and performs peak signal detection in each time range to determine a plurality of peaks. The signal processing module 433 may be implemented as a processing circuit or a processor implementing the functionality of the signal processing module 433 by executing a corresponding computer program.

The determining module 434 is configured to determine whether the signal strength of the analog amplified ultrasound echo signal exceeds a conversion threshold of analog-to-digital conversion, and whether the signal amplitude of one or more peaks meets a preset condition of gain adjustment. The determination module 434 may be implemented as a corresponding circuit or processor, which implements the functionality of the determination module 434 by executing a corresponding computer program.

If the decision module 434 determines that the signal strength of the analog amplified ultrasound echo signal exceeds the conversion threshold of the analog-to-digital conversion, the gain adjustment module 435 adjusts the analog gain for analog amplification of the ultrasound echo signal. Illustratively, the gain adjustment module 435 adjusts the gain value of a portion or the entirety of the analog gain curve to prevent the analog amplified ultrasound echo signal from being too large beyond the conversion threshold of the analog-to-digital conversion.

If the decision module 434 determines that the signal amplitude of one or more peaks meets the preset condition for gain adjustment, the gain adjustment module 435 performs a piecewise gain adjustment on the measurement signal.

For example, the preset condition is whether the difference between the signal amplitudes of the respective peaks exceeds a set threshold, and if the determining module 434 determines that the difference between the signal amplitudes of the respective peaks exceeds the set threshold, the gain adjusting module 435 performs a piecewise gain adjustment on the measurement signal. For example, the gain adjustment module 435 may perform a step gain adjustment on the measurement signal by increasing the signal amplitude of the smaller one of the peaks so that the difference between the signal amplitudes of the peaks does not exceed a set threshold.

Illustratively, the preset condition is whether the signal amplitude of each peak is lower than the set amplitude, and if the determining module 434 determines that there is a peak with a signal amplitude lower than the set amplitude in the measurement signal, the gain adjusting module 435 performs a step-by-step gain adjustment on the peak lower than the set amplitude in the measurement signal. For example, the gain adjustment module 435 may perform a piecewise gain adjustment on the measurement signal by increasing the signal amplitude of the peak below the set amplitude to at least not below the set amplitude.

The process or principle of the segmented gain adjustment is shown in fig. 3A and 3B, and will not be described herein.

The detection result obtaining module 436 is configured to calculate corresponding eyeball biomass by sound velocity matching according to the positions of the multiple peaks detected in the measurement signal.

The determination module 434, the gain adjustment module 435, and the detection result acquisition module 436 may be implemented by a processor executing corresponding computer programs.

It should be understood that, after performing analog gain adjustment on the ultrasonic echo signal and/or performing piecewise gain adjustment on the measurement signal, the processor needs to process the measurement signal again to obtain the signal amplitudes and positions of the multiple peaks and the respective peaks based on the adjusted measurement signal, and then calculate the biomass of the corresponding eyeball through sound velocity matching according to the positions of the respective peaks.

The display is used for displaying the adjusted measuring signal and the detection result.

According to the ophthalmic ultrasonic imaging device provided by the embodiment of the invention, when the signal amplitude of one or more wave crests is determined to accord with the gain adjustment condition, the segmented gain adjustment is carried out on the measurement signal, and the signal amplitude of each wave crest is adjusted to be within a reasonable range through the segmented gain adjustment, so that the accuracy of the measurement result is improved.

Fig. 5 shows a schematic flow diagram of a method for automatically adjusting an ophthalmic biometric measurement gain according to an embodiment of the present invention.

As shown in fig. 5, the method for automatically adjusting the ophthalmic biometric measurement gain according to the present embodiment includes:

in step S601, measurement signals reflecting a plurality of biomasses of the eyeball are acquired. The measurement signal may be obtained by transmitting an ultrasonic wave to the eyeball and receiving an ultrasonic echo signal, and then processing the ultrasonic echo signal. The measurement signal may also be obtained from an internal memory of the ophthalmic ultrasound imaging apparatus or from an external device. Biomass includes, for example, the corneal thickness, anterior chamber depth, lens thickness, vitreous length, and ocular axis length of the eyeball.

In step S602, a plurality of peaks are detected from the measurement signal based on the ultrasonic reflection characteristics corresponding to each biomass, and the signal amplitude of each peak is obtained.

Illustratively, a plurality of time ranges for performing peak detection in the measurement signal are determined according to the reflection time length of the ultrasonic wave corresponding to each biomass, and peak signal detection is performed in each time range to determine a plurality of peaks.

Step S603, when the signal amplitudes of one or more peaks meet the gain adjustment condition, performing a piecewise gain adjustment on the measurement signal.

Illustratively, the gain adjustment condition is whether the signal amplitudes of the respective peaks differ by more than a set threshold, and if it is determined that the signal amplitudes of two or more peaks among the respective peaks differ by more than a set threshold, the measurement signal is subjected to a piece-wise gain adjustment. For example, the measurement signal may be adjusted by increasing the signal amplitudes of the peaks having smaller signal amplitudes among the peaks so that the difference between the signal amplitudes of the peaks does not exceed a set threshold.

Illustratively, the gain adjustment condition is whether the signal amplitude of each peak is lower than a set amplitude, and if it is determined that a peak with a signal amplitude lower than the set amplitude exists in the measurement signal, the peak lower than the set amplitude in the measurement signal is subjected to a piecewise gain adjustment. Illustratively, the measurement signal may be adjusted in a stepwise gain by increasing the signal amplitude of the peak below the set amplitude to at least not below the set amplitude.

In this embodiment, the segmented gain adjustment of the measurement signal can be implemented by superimposing a segmented gain adjustment curve on the original measurement signal curve. Fig. 3A and 3B show schematic diagrams of a segmented gain adjustment in ophthalmic ultrasound imaging according to an embodiment of the present invention.

Fig. 6 shows a schematic structural block diagram of an ophthalmic biometric measuring apparatus according to an embodiment of the present invention.

As shown in fig. 6, the present embodiment provides an ophthalmic biometric measurement device 700 including one or more processors 710, working collectively or individually; one or more memories 720, the one or more memories 720 storing one or more computer programs that, when executed by the one or more processors, cause the one or more processors 710 to perform:

acquiring measurement signals for reflecting a plurality of biomasses of eyeballs;

detecting a plurality of wave crests from the measurement signal according to the ultrasonic reflection characteristics corresponding to the biomass, and obtaining the signal amplitude of each wave crest; and

and when the signal amplitude of one or more peaks is determined to meet the gain adjustment condition, performing segmented gain adjustment on the measurement signal.

When the signal amplitude of one or more peaks accords with a gain adjustment condition, performing segmented gain adjustment on the measurement signal, wherein the method comprises the following steps:

when the difference between the signal amplitudes of the wave crests exceeds a set threshold value, increasing the signal amplitude of the wave crest with smaller signal amplitude in the wave crests so that the difference between the signal amplitudes of the wave crests does not exceed the set threshold value

When the signal amplitude of one or more wave crests accords with a gain adjustment condition, performing segmented gain adjustment on the measurement signal, wherein the step of performing segmented gain adjustment on the measurement signal comprises the following steps:

and when the signal amplitude of one or more peaks is lower than the peak with the set amplitude, increasing the signal amplitude of the peak with the lower set amplitude to be at least not lower than the set amplitude.

In addition, the embodiment of the invention also provides a computer storage medium, and the computer storage medium is stored with the computer program. One or more computer program instructions may be stored on the computer-readable storage medium, and a processor may execute the program instructions stored by the storage device to implement the functions (implemented by the processor) of the embodiments of the present invention described herein and/or other desired functions, such as to perform the corresponding steps of the ophthalmic ultrasound imaging method and the method for automatically adjusting ophthalmic biometric gain according to the embodiments of the present invention, and various applications and various data, such as various data used and/or generated by the applications, and the like, may also be stored in the computer-readable storage medium.

For example, the computer storage medium may include, for example, a memory card, a storage component of a tablet computer, a hard disk of a personal computer, a Read Only Memory (ROM), an Erasable Programmable Read Only Memory (EPROM), a portable compact disc read only memory (CD-ROM), a USB memory, or any combination of the above storage media.

In summary, according to the ophthalmic ultrasonic imaging method, the method for automatically adjusting the ophthalmic biomass measurement gain, the ophthalmic ultrasonic imaging apparatus, and the ophthalmic biomass measurement apparatus of the embodiments of the present invention, when it is determined that the signal amplitude of one or more peaks meets the gain adjustment condition, the segmented gain adjustment is performed on the measurement signal, and the signal amplitude of each peak is adjusted to a reasonable range through the segmented gain adjustment, so that the accuracy of the measurement result is improved, and the operation of the doctor's examination is reduced.

The segmented gain adjustment described in the present invention means that when performing gain adjustment on a measurement signal, it is not necessary to perform integral and uniform gain adjustment on the measurement signal, but the signal segment of the measurement signal to be adjusted is adjusted, and the degree and manner of adjusting the signal segment to be adjusted may be different. For example, the step gain adjustment may be performed on one or more of the plurality of peaks, or may be performed on all of the plurality of peaks. For example, the step gain adjustment may be to amplify the signal amplitude of one peak to 2 times before the adjustment and amplify the signal amplitude of the other peak to 3 times before the adjustment. In addition, the piecewise gain adjustment of the measurement signal is directed to the signal containing the peak obtained after the envelope processing, the purpose of the gain adjustment is to amplify the signal amplitude of the peak within the envelope range, and synchronous amplification is not desired for the signal outside the envelope, so that the signal or curve of the gain adjustment corresponds to the envelope of the measurement signal, especially to the peak, and forms a piecewise gain adjustment signal or curve with a sudden change in gain value.

Although the illustrative embodiments have been described herein with reference to the accompanying drawings, it is to be understood that the foregoing illustrative embodiments are merely exemplary and are not intended to limit the scope of the invention thereto. Various changes and modifications may be effected therein by one of ordinary skill in the pertinent art without departing from the scope or spirit of the present invention. All such changes and modifications are intended to be included within the scope of the present invention as set forth in the appended claims.

Those of ordinary skill in the art will appreciate that the various illustrative elements and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware or combinations of computer software and electronic hardware. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the implementation. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present invention.

In the several embodiments provided in the present application, it should be understood that the disclosed apparatus and method may be implemented in other ways. For example, the above-described device embodiments are merely illustrative, and for example, the division of the units is only one logical functional division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another device, or some features may be omitted, or not executed.

In the description provided herein, numerous specific details are set forth. It is understood, however, that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.

Similarly, it should be appreciated that in the description of exemplary embodiments of the invention, various features of the invention are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the invention and aiding in the understanding of one or more of the various inventive aspects. However, the method of the present invention should not be construed to reflect the intent: that the invention as claimed requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive aspects lie in less than all features of a single disclosed embodiment. Thus, the claims following the detailed description are hereby expressly incorporated into this detailed description, with each claim standing on its own as a separate embodiment of this invention.

It will be understood by those skilled in the art that all of the features disclosed in this specification (including any accompanying claims, abstract and drawings), and all of the processes or elements of any method or apparatus so disclosed, may be combined in any combination, except combinations where such features are mutually exclusive. Each feature disclosed in this specification (including any accompanying claims, abstract and drawings) may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise.

Furthermore, those skilled in the art will appreciate that while some embodiments described herein include some features included in other embodiments, rather than other features, combinations of features of different embodiments are meant to be within the scope of the invention and form different embodiments. For example, in the claims, any of the claimed embodiments may be used in any combination.

The various component embodiments of the invention may be implemented in hardware, or in software modules running on one or more processors, or in a combination thereof. Those skilled in the art will appreciate that a microprocessor or Digital Signal Processor (DSP) may be used in practice to implement some or all of the functionality of some of the modules according to embodiments of the present invention. The present invention may also be embodied as apparatus programs (e.g., computer programs and computer program products) for performing a portion or all of the methods described herein. Such programs implementing the present invention may be stored on computer-readable media or may be in the form of one or more signals. Such a signal may be downloaded from an internet website or provided on a carrier signal or in any other form.

It should be noted that the above-mentioned embodiments illustrate rather than limit the invention, and that those skilled in the art will be able to design alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim. The invention may be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. In the unit claims enumerating several means, several of these means may be embodied by one and the same item of hardware. The usage of the words first, second and third, etcetera do not indicate any ordering. These words may be interpreted as names.