阅读说明：本技术 一种大小鼠脑立体定位仪固定结构 (Fixing structure of rat brain stereotaxic instrument ) 是由 丁陈禹 蚁雪涵 康德智 于 2020-07-31 设计创作，主要内容包括：本发明公开了一种大小鼠脑立体定位仪固定结构,包括操作板,所述操作板通过调节机构连接有固定柱,所述固定柱上安装有固牙机构；所述操作板的顶部固定连接有两个对称设置的固定块a。本发明中,该大小鼠脑立体定位仪固定结构,调节精度高,在对大、小鼠进行固定的过程中,不会出现因为调节不当导致的牙齿出血或者耳膜破裂的情况发生；支撑板的顶部安装有磁铁a和磁铁b,便于对纸巾或者垫布进行固定的效果,避免大、小鼠在进行试验的过程中,发生大小便失禁导致支撑板被污染的情况发生；支撑板的高度可以根据需要进行升降,便于快速使用耳棒和固牙杆对大、小鼠进行固定,提高实验效率。(The invention discloses a fixing structure of a rat brain stereotaxic instrument, which comprises an operation board, wherein the operation board is connected with a fixing column through an adjusting mechanism, and a tooth fixing mechanism is arranged on the fixing column; the top of the operating panel is fixedly connected with two symmetrically arranged fixed blocks a. According to the fixing structure of the rat brain stereotaxic apparatus, the adjusting precision is high, and the condition that teeth bleed or eardrum rupture caused by improper adjustment can not occur in the process of fixing rats and mice; the magnet a and the magnet b are arranged at the top of the supporting plate, so that the effect of fixing tissues or cloth mats is facilitated, and the situation that the supporting plate is polluted due to incontinence of urine and feces in the process of a large mouse or a small mouse in a test is avoided; the height of the supporting plate can be lifted as required, so that the ear rod and the tooth fixing rod can be conveniently and quickly used for fixing the big mouse and the small mouse, and the experimental efficiency is improved.)

1. A fixing structure of a rat brain stereotaxic instrument is characterized by comprising an operation board (1), wherein the operation board (1) is connected with a fixing column (6) through an adjusting mechanism, and a tooth fixing mechanism is installed on the fixing column (6);

the top of the operating plate (1) is fixedly connected with two symmetrically-arranged fixed blocks a (13), the fixed blocks a (13) are connected with a lifting block b (16) through an adjusting mechanism, a screw rod b (14) is connected onto the lifting block b (16) in a threaded manner, one end of the screw rod b (14) penetrates through the lifting block b (16) and is rotatably connected with a clamping block (18), the clamping block (18) is connected with an ear rod (15) through a fixed screw, a clamping groove corresponding to the ear rod (15) is formed in the clamping block (18), and the clamping block (18) is connected with the lifting block b (16) through a limiting mechanism;

the adjusting mechanism comprises a screw rod a (2) which is rotatably connected with the operating plate (1) and the fixed block a (13), one end of the screw rod a (2) penetrates through the operating plate (1) and the fixed block a (13) respectively and extends outwards, a sliding block a (4) is sleeved on the outer side wall of the screw rod a (2) in a threaded manner, and the sliding block a (4) is connected with a fixed column (6) and a lifting block b (16) respectively;

the lifting support plate (20) is installed on the operating plate (1), and four support legs (24) are installed at the bottom of the operating plate (1).

2. The fixing structure of the rat and mouse brain stereotaxic instrument according to claim 1, wherein the top of one of the sliding blocks a (4) is connected with a fixed column (6) through a square column (5), and the bottom of the fixed column (6) is provided with an installation groove a corresponding to the square column (5).

3. The fixing structure of the rat brain stereotaxic instrument according to claim 1, wherein the tooth fixing mechanism is mounted on an elevating block a (11) on the fixing column (6), and a tooth fixing rod (12) and a pressing plate (9) are mounted on the elevating block a (11).

4. The fixing structure of the rat brain stereotaxic instrument according to claim 3, wherein the lifting block a (11) is connected with a fixed column (6) through a sliding block b (7), a sliding groove corresponding to the sliding block b (7) is formed in the fixed column (6), and the lifting block a (11) is connected with the inner side wall of the sliding groove through a limiting screw (8);

the pressing plate (9) is connected with the top of the lifting block a (11) through an elastic piece and an adjusting screw (10), and an adjusting opening corresponding to the adjusting screw (10) is formed in the pressing plate (9);

the tooth fixing rod (12) is connected with a lifting block a (11) through a bolt, and a mounting groove b corresponding to the tooth fixing rod (12) is formed in the lifting block a (11).

5. The fixing structure of the rat brain stereotaxic instrument according to claim 1, wherein the limiting mechanism comprises a telescopic rod a (17) fixedly connected to the clamping block (18), and the telescopic rod a (17) is connected with the lifting block b (16) through a connecting block (19).

6. The fixing structure of the rat brain stereotaxic apparatus according to claim 1, wherein two U-shaped plates (25) are fixedly connected to the bottom of the operating plate (1), one of the U-shaped plates (25) is arranged below the supporting plate (20), a fixed block b (26) is fixedly connected to the inner bottom of the U-shaped plate (25), the two fixed blocks b (26) are connected to the same lead screw c (23) through a rotating member, one end of the lead screw c (23) penetrates through the rotating member and extends outwards, the lead screw c (23) is connected to the bottom of the supporting plate (20) through a connecting mechanism, and the inner bottom of one of the U-shaped plates (25) is connected to the bottom of the supporting plate (20) through a telescopic rod b (30).

7. The fixing structure of the rat and mouse brain stereotaxic instrument according to claim 6, wherein the connecting mechanism comprises a sliding block c (27) sleeved on the outer side wall of the screw rod c (23) in a threaded manner, the bottom of the supporting plate (20) is fixedly connected with a fixed block c (29), the fixed block c (29) and the sliding block c (27) are both rotatably connected with rotating shafts, and the two rotating shafts are connected through a connecting rod (28).

8. The fixing structure of the rat and mouse brain stereotaxic instrument according to the claims 1 and 6, wherein one end of the screw rod a (2), one end of the screw rod b (14) and one end of the screw rod c (23) are fixedly connected with a handle (3).

9. The fixing structure of the rat and mouse brain stereotaxic instrument according to claim 1, wherein a magnet a (21) is installed on the top of the supporting plate (20), and a magnet b (22) is connected to the top of the magnet a (21) in an attracting manner.

Technical Field

The invention relates to the fields related to medical research and medical equipment, in particular to a fixing structure of a rat brain stereotaxic instrument.

Background

The brain stereotaxic apparatus, also called a brain fixing device, determines the position of some nerve structures under the cortex by using a three-dimensional coordinate system defined by a mark or other reference points outside the skull so as to carry out directional stimulation, damage, medicine injection, electric potential guidance and other researches on the nerve structures under the condition of non-direct-view exposure. The animal brain stereotaxic apparatus is important research equipment in the fields of nerve anatomy, nerve physiology, neuropharmacology, neurosurgery and the like, is used for performing directional injection, stimulation, damage, electric potential guidance and other operations on a nerve structure, and can be used for the researches of cerebral hemorrhage animal model establishment, Parkinson's disease animal model establishment, epilepsy animal model establishment, intracerebral tumor model establishment, learning and memory, intracerebral neural stem cell transplantation, cerebral ischemia and the like.

At present, the commonly used brain stereotaxic instruments for rats and mice are generally provided with a portal hook and ear rods at two sides, the portal teeth of the rats and the mice are fixed on the portal hook, the ear rods at the two sides are aligned to the auditory canals of the rats and the mice, and the heads of the rats and the mice are fixed by utilizing a three-point positioning principle, so that the follow-up research is facilitated; however, when the brain stereotaxic apparatus is used for positioning rats and mice at present, the following defects exist:

1. when a big mouse and a small mouse are fixed, the upper teeth of the big mouse and the small mouse need to be fixed by using the upper jaw, but a sliding block provided with the upper jaw slides on an operation table, the sliding block needs to be fixed by using a screw, when the big mouse and the small mouse are fixed by using the upper teeth, the sliding block needs to be manually pushed to move on the operation table to adjust the position of the sliding block, and the big mouse and the small mouse are fixed by using the method, so that the adjustment precision is poor, the big mouse and the small mouse can be wounded, even the teeth of the big mouse and the small mouse bleed, and the experiment is influenced;

2. when using the ear stick to fix big, the both sides duct of mouse, also adopt manual promotion ear stick to remove toward big, the head of mouse, after the ear stick supports big, the duct of mouse, adopt the screw to fix, and adopt this mode fixed, it is relatively poor to adjust the precision, simultaneously, the condition that will big, the eardrum of mouse is poked out can also appear taking place, lead to big, the mouse struggles on the operation panel, influence going on of experiment.

Therefore, a fixing structure of a rat brain stereotaxic instrument is provided.

Disclosure of Invention

The invention aims to provide a fixing structure of a rat brain stereotaxic apparatus, which aims to solve the problems in the background technology.

In order to achieve the purpose, the invention adopts the following technical scheme:

a fixing structure of a rat brain stereotaxic instrument comprises an operation board, wherein the operation board is connected with a fixing column through an adjusting mechanism, and a tooth fixing mechanism is installed on the fixing column;

the top of the operating plate is fixedly connected with two symmetrically arranged fixed blocks a, the fixed blocks a are connected with a lifting block b through an adjusting mechanism, a lead screw b is connected onto the lifting block b in a threaded manner, one end of the lead screw b penetrates through the lifting block b and is rotatably connected with a clamping block, the clamping block is connected with an ear rod through a fixed screw, a clamping groove corresponding to the ear rod is formed in the clamping block, and the clamping block is connected with the lifting block b through a limiting mechanism;

the adjusting mechanism comprises a screw rod a which is rotatably connected with the operating plate and the fixed block a, one end of the screw rod a penetrates through the operating plate and the fixed block a respectively and extends outwards, a sliding block a is sleeved on the outer side wall of the screw rod a in a threaded manner, and the sliding block a is connected with the fixed column and the lifting block b respectively;

the operation panel is provided with a liftable supporting plate, and the bottom of the operation panel is provided with four supporting legs.

Preferably, the top of one of the sliding blocks a is connected with a fixed column through a square column, and the bottom of the fixed column is provided with a mounting groove a corresponding to the square column.

Preferably, the tooth fixing mechanism is mounted on an elevating block a on the fixing column, and the elevating block a is provided with a tooth fixing rod and a pressing plate.

Preferably, the lifting block a is connected with a fixed column through a sliding block b, a sliding groove corresponding to the sliding block b is formed in the fixed column, and the lifting block a is connected with the inner side wall of the sliding groove through a limiting screw;

the pressing plate is connected with the top of the lifting block a through an elastic piece and an adjusting screw, and an adjusting opening corresponding to the adjusting screw is formed in the pressing plate;

the tooth fixing rod is connected with a lifting block a through a bolt, and a mounting groove b corresponding to the tooth fixing rod is arranged on the lifting block a.

Preferably, the limiting mechanism comprises an expansion rod a fixedly connected to the clamping block, and the expansion rod a is connected with the lifting block b through a connecting block.

Preferably, two U templates of bottom fixedly connected with of operation panel, one of them set up the below in the backup pad on the U template, the interior bottom fixedly connected with fixed block b of U template, two fixed block b all is connected with same root lead screw c through rotating, lead screw c's one end runs through and rotates piece and outside extension, lead screw c passes through coupling mechanism and is connected with the bottom of backup pad, and one of them the interior bottom of U template is passed through telescopic link b and is connected with the bottom of backup pad.

Preferably, coupling mechanism includes that the screw thread cup joints the slider c on the lead screw c lateral wall, the bottom fixedly connected with fixed block c of backup pad, all rotate on fixed block c and the slider c and be connected with the pivot, two the pivot passes through the connecting rod and connects.

Preferably, one end of the screw rod a, one end of the screw rod b and one end of the screw rod c are fixedly connected with handles.

Preferably, the top of the ear rod and the top of the operation plate are both provided with a graduated scale.

Preferably, a magnet a is installed at the top of the supporting plate, and a magnet b is connected to the top of the magnet a in an attracting manner.

Compared with the prior art, the invention has the beneficial effects that:

1. according to the fixing structure of the rat brain stereotaxic instrument, the positions of the tooth fixing rod and the pressing plate are adjusted in a mode that the screw rod rotates to drive the sliding block to move on the operating plate, the situation that the position of the sliding block is affected due to hand shaking in the adjusting process cannot occur, the adjusting precision is high, the adjusting is convenient, and in addition, the tooth bleeding of rats and mice cannot be caused;

2. according to the fixing structure of the rat and mouse brain stereotaxic instrument, the mode that the screw rod rotates to drive the sliding block to move on the operating plate is adopted, so that the positions of the two ear rods can be adjusted accurately, the effect of resisting auditory canals of rats and mice is achieved, the adjusting precision is high, and the situation that the ear rods poke the eardrums of the rats and the mice can not occur;

3. according to the invention, the magnet a and the magnet b are arranged on the top of the supporting plate, so that the effect of fixing tissues or cloth liners is facilitated, and the situation that the supporting plate is polluted due to incontinence of urine and feces in the process of testing by big and small mice is avoided;

4. according to the invention, the height of the supporting plate can be lifted according to the requirement, so that the ear rod and the tooth fixing rod can be conveniently and rapidly used for fixing the big mouse and the small mouse, and the experimental efficiency is improved.

Drawings

Fig. 1 is a schematic structural diagram of a fixing structure of a rat brain stereotaxic apparatus according to the present invention;

fig. 2 is a schematic view of a connection structure of an operation panel, a screw a, a handle, a slider a, a square column, a fixed column and a tooth fixing mechanism in the fixing structure of the rat brain stereotaxic apparatus provided by the invention;

fig. 3 is a schematic view of a connection structure of an operation board, a fixed block a, a screw rod a, a handle and a slide block a in the fixing structure of the rat brain stereotaxic apparatus provided by the invention;

fig. 4 is a schematic view of a connection structure of a screw rod c, an operation plate, a connection mechanism, a U-shaped plate, support legs, a fixed block c, a handle and a support plate in the fixing structure of the rat brain stereotaxic apparatus provided by the invention;

fig. 5 is a schematic view of a connection structure of an operation plate, a support plate, a fixed block c, a screw rod c, a telescopic rod and a U-shaped plate in the fixing structure of the rat brain stereotaxic apparatus provided by the invention.

In the figure: 1. an operation panel; 2. a screw rod a; 3. a handle; 4. a slide block a; 5. a square column; 6. fixing a column; 7. a slide block b; 8. a limiting screw; 9. a pressing plate; 10. adjusting screws; 11. a lifting block a; 12. a tooth fixing rod; 13. a fixed block a; 14. a screw rod b; 15. an ear stick; 16. a lifting block b; 17. a telescopic rod a; 18. a clamping block; 19. connecting blocks; 20. a support plate; 21. a magnet a; 22. a magnet b; 23. a screw rod c; 24. a support leg; 25. a U-shaped plate; 26. a fixed block b; 27. a slide block c; 28. a connecting rod; 29. a fixed block c; 30. and (b) an expansion rod.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

Referring to fig. 1-5, the invention also provides a fixing structure of the rat brain stereotaxic instrument, which comprises an operation board 1, wherein the operation board 1 is connected with a fixing column 6 through an adjusting mechanism, and a tooth fixing mechanism is arranged on the fixing column 6;

the top of the operating panel 1 is fixedly connected with two symmetrically arranged fixed blocks a13, the fixed block a13 is connected with a lifting block b16 through an adjusting mechanism, a screw rod b14 is connected to the lifting block b16 in a threaded manner, one end of the screw rod b14 penetrates through the lifting block b16 and is rotatably connected with a clamping block 18, the clamping block 18 is connected with an ear rod 15 through a fixed screw, a clamping groove corresponding to the ear rod 15 is formed in the clamping block 18, and the clamping block 18 is connected with the lifting block b16 through a limiting mechanism;

the adjusting mechanism comprises a screw rod a2 which is rotatably connected with the operating plate 1 and a fixed block a13, one end of the screw rod a2 penetrates through the operating plate 1 and the fixed block a13 respectively and extends outwards, a sliding block a4 is sleeved on the outer side wall of the screw rod a2 in a threaded manner, and a sliding block a4 is connected with the fixed column 6 and the lifting block b16 respectively;

the operation panel 1 is provided with a liftable support plate 20, and the bottom of the operation panel 1 is provided with four support legs 24.

The fixing mechanism is used for fixing teeth of rats and mice.

The rotating screw rod a2 rotates to drive the sliding block a4 to move on the operating panel 1 and the fixed block a13 respectively, the position of the fixed column 6 on the operating panel 1 and the position of the lifting block b16 on the fixed block a13 can be adjusted, and the heads of the rat and the mouse can be fixed conveniently from three directions. And the mode is adopted for adjustment, the adjustment precision is high, and the big and the small mice cannot be injured.

In this embodiment, furthermore, the top of one of the sliders a4 is connected with the fixed column 6 through the square column 5, and the bottom of the fixed column 6 is provided with an installation groove a corresponding to the square column 5. The installation and the disassembly between the fixed column 6 and the square column 5 are convenient.

In the embodiment, the tooth fixing mechanism is further mounted on the lifting block a11 on the fixing column 6, and the tooth fixing rod 12 and the pressing plate 9 are mounted on the lifting block a 11. The teeth of the rat and the mouse are placed in the tooth fixing grooves on the tooth fixing rod 12 through the cooperation of the tooth fixing rod 12 and the pressing plate 9, the head of the rat and the head of the mouse are pressed on the tooth fixing rod 12 through the pressing plate 9, and the head of the rat and the head of the mouse can be fixed together with the lifting block a 11.

In this embodiment, further, the lifting block a11 is connected with the fixed column 6 through the slider b7, the fixed column 6 is provided with a sliding groove corresponding to the slider b7, and the lifting block a11 is connected with the inner side wall of the sliding groove through the limit screw 8; the position of the lifting block a11 can be adjusted up and down conveniently.

The pressing plate 9 is connected with the top of the lifting block a11 through an elastic piece and an adjusting screw 10, and the pressing plate 9 is provided with an adjusting port corresponding to the adjusting screw 10; the position of the pressing plate 9 is easily adjusted.

The tooth fixing rod 12 is connected with the lifting block a11 through a bolt, and the lifting block a11 is provided with a mounting groove b corresponding to the tooth fixing rod 12, so that the tooth fixing rod 12 can be conveniently mounted and dismounted, and the tooth fixing rod 12 suitable for different sizes and mice can be conveniently replaced.

In this embodiment, further, the limiting mechanism includes a telescopic rod a17 fixedly connected to the clamping block 18, and the telescopic rod a17 is connected to the lifting block b16 through the connecting block 19. When the screw rod b14 is prevented from rotating, the clamping block 18 rotates along with the rotation of the screw rod b14, and the left and right movement of the clamping block 18 is limited, so that the ear rod 15 is adjusted to move on the operating panel 1 in parallel, and the heads of the rat and the mouse are fixed.

The lifting block b16 is provided with a sliding groove corresponding to the ear rod 15 so that the ear rod 15 can be kept horizontal.

In this embodiment, further, two U-shaped plates 25 are fixedly connected to the bottom of the operating panel 1, one of the two U-shaped plates 25 is disposed below the supporting plate 20, a fixing block b26 is fixedly connected to the inner bottom of the U-shaped plate 25, both the two fixing blocks b26 are connected to the same lead screw c23 through a rotating member, one end of the lead screw c23 penetrates through the rotating member and extends outward, the lead screw c23 is connected to the bottom of the supporting plate 20 through a connecting mechanism, and the inner bottom of one of the U-shaped plates 25 is connected to the bottom of the supporting plate 20 through a telescopic rod b 30.

In this embodiment, further, coupling mechanism includes that the screw thread cup joints slider c27 on the lateral wall of lead screw c23, and the bottom fixedly connected with fixed block c29 of backup pad 20, all rotates on fixed block c29 and the slider c27 to be connected with the pivot, and two pivots pass through connecting rod 28 and connect. The height of the supporting plate 20 can be conveniently adjusted so as to rapidly fix the head of a big mouse or a small mouse.

In this embodiment, further, one end of the screw a2, one end of the screw b14, and one end of the screw c23 are all fixedly connected with the handle 3. The rotating screw rod a2, the screw rod b14 and the screw rod c23 are convenient to rotate.

In this embodiment, a magnet a21 is mounted on the top of the supporting plate 20, and a magnet b22 is attached to the top of the magnet a 21. The fixing effect of the paper towel or the cloth liner is convenient, and the situation that the supporting plate 20 is polluted due to incontinence of urine and feces in the process of a test by a rat or a mouse is avoided. Paper handkerchief or floorcloth are placed at the top of backup pad 20, so adopt the mode of magnet actuation to fix, prevent big, the mouse in the in-process of carrying out the experiment, because ear stick 15 supports uncomfortable that the duct leads to, the operation takes place for floorcloth or paper handkerchief take place unknown change.

In the invention, when the brain stereotaxic apparatus is required to fix the rat and mouse, the handle 3 is firstly rotated to adjust the position of the fixing column 6, the tooth fixing rod 12 and the pressing plate 9 are used for fixing the upper teeth of the rat and mouse, then the height of the lifting block b16 is adjusted, and the two ear rods 15 are adjusted to clamp and fix the auditory canals of the rat and mouse in opposite directions, so that the rat and mouse can be fixed on the top of the supporting plate 20. In the process of fixing the big mouse and the small mouse, the screw rod c23 can be rotated as required to adjust the height of the supporting plate 20, so that the big mouse and the small mouse can be fixed quickly.

According to the fixing structure of the rat brain stereotaxic instrument, the positions of the tooth fixing rod 12 and the pressing plate 9 are adjusted in a mode that the screw rod rotates to drive the sliding block to move on the operating plate 1, the situation that the position of the sliding block is affected due to hand shaking in the adjusting process cannot occur, the adjusting precision is high, the adjusting is convenient, and in addition, tooth bleeding of rats and mice cannot be caused.

According to the fixing structure of the rat and mouse brain stereotaxic instrument, the screw rod is adopted to rotate to drive the sliding block to move on the operation plate 1, so that the positions of the two ear rods 15 can be accurately adjusted, the effect of resisting the ear canals of rats and mice is achieved, the adjusting precision is high, and the situation that the ear membranes of the rats and the mice are poked through the ear rods 15 cannot occur.

In the invention, the magnet a21 and the magnet b22 are arranged at the top of the support plate 20, so that the effect of fixing tissues or cloth liners is facilitated, and the situation that the support plate 20 is polluted due to incontinence of urine and feces in the process of testing by big and small mice is avoided.

In the invention, the height of the supporting plate 20 can be lifted according to the requirement, so that the ear rod 15 and the tooth fixing rod 12 can be conveniently and rapidly used for fixing the rat and the mouse, and the experimental efficiency is improved.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.