阅读说明：本技术 一种用于动物的tms干预装置 (TMS intervention device for animals ) 是由 华续赟 郑谋雄 吴佳佳 邢相欣 马震震 马洁 李思思 魏冬 薛炘 李瑜琳 于 2021-06-07 设计创作，主要内容包括：本发明公开了一种用于动物的TMS干预装置,包括：TMS设备、安装部、转盘部和支撑部,TMS设备至少包括磁刺激线圈,安装部设置于转盘部的正上方,转盘部可转动地设置于支撑部上,磁刺激线圈安装于安装部上,转盘部上沿环向依次设置有至少两限制孔,支撑部上设置有一下通口,每一限制孔均可操作地正对一下通口设置,下通口的下方放置有实验动物,磁刺激线圈向下产生有一脉冲磁场,脉冲磁场依次穿过其中一限制孔和下通口对实验动物进行干预。通过对本发明的应用,形成对磁刺激线圈产生的脉冲磁场即磁力线的范围进行合适地调节,还可对磁刺激线圈与实验动物之间的距离进行调整,实现对TMS设备输出的精确调控,也方便实验人员进行高效的实验操作。(The invention discloses a TMS intervention device for animals, which comprises: TMS equipment, the installation department, carousel portion and supporting part, TMS equipment includes magnetic stimulation coil at least, the installation department sets up directly over the carousel portion, the carousel portion rotationally sets up on the supporting part, magnetic stimulation coil installs on the installation department, it has set gradually two at least restriction holes to follow the hoop on the carousel portion, be provided with the opening once on the supporting part, each restriction hole all is operatively just to opening setting once, laboratory animal has been placed to the below of opening down, magnetic stimulation coil produces downwards has a pulsed magnetic field, pulsed magnetic field passes one of them restriction hole in proper order and intervenes laboratory animal with opening down. By applying the invention, the range of the pulse magnetic field generated by the magnetic stimulation coil, namely the magnetic force line, can be properly adjusted, the distance between the magnetic stimulation coil and an experimental animal can be adjusted, the accurate regulation and control of TMS equipment output can be realized, and the high-efficiency experimental operation of experimenters can be conveniently carried out.)

1. A TMS intervention device for an animal, comprising: the TMS device comprises a TMS device, an installation part, a turntable part and a support part, wherein the TMS device at least comprises a magnetic stimulation coil, the mounting part is arranged right above the turntable part, the turntable part is rotatably arranged on the supporting part, the magnetic stimulation coil is arranged on the mounting part, at least two limiting holes are sequentially arranged on the turntable part along the annular direction, the supporting part is provided with a lower through hole, the inner diameter of one limiting hole is larger than that of the other limiting hole, each limiting hole is operably arranged opposite to one lower through hole, the inner diameter of the limiting hole is equal to or less than that of the lower port, an experimental animal is placed below the lower port, the magnetic stimulation coil downwards generates a pulse magnetic field, and the pulse magnetic field sequentially penetrates through one of the limiting holes and the lower through opening to intervene the experimental animal.

2. The TMS intervention device for animals of claim 1, wherein the magnetic stimulation coil is disposed at an upper end of the mounting portion, the mounting portion having an upper port disposed thereon, the pulsed magnetic field operable to pass through the upper port, one of the limiting holes and the lower port in sequence from top to bottom.

3. The TMS intervention device for an animal of claim 2, wherein an inner diameter of the upper port and an inner diameter of the lower port are equal.

4. The TMS intervention device for animals of claim 1, wherein the turntable portion is made of ferromagnetic material and is of ferrous plate construction.

5. The TMS intervention device for an animal of claim 1, wherein the turntable portion and the support portion are both made of ferromagnetic material.

6. The TMS intervention device for animals of claim 1, wherein said TMS device further comprises: the equipment main part passes through the connecting wire with the magnetic stimulation coil is connected, the installation cover is located the magnetic stimulation coil is close to one of connecting wire is served.

7. The TMS intervention device for animals of claim 6, wherein a clamp is arranged on one side of the upper surface of the mounting portion, a clamping groove is formed on the clamp, the clamping groove is matched with the mounting sleeve, and the magnetic stimulation coil is fixedly mounted on the mounting portion through the clamping of the clamping groove and the mounting sleeve.

8. The TMS intervention device for animals of claim 1, further comprising: the support is arranged in the vertical direction, the base is fixedly installed at the lower end of the support, the lower surface of the base is provided with a friction enhancing structure, the installation part is installed on the upper portion of the support, and the supporting part is fixedly installed on the lower portion of the support.

9. The TMS intervention device for an animal of claim 8, wherein the scaffold is a telescoping structure, the scaffold comprising: the supporting part comprises a lower supporting leg and an upper supporting leg, the upper supporting leg is connected with the lower supporting leg in a sliding mode along the vertical direction, the mounting part is fixedly connected with the upper supporting leg, and the supporting part is fixedly connected with the lower supporting leg.

10. The TMS intervention device for animals of claim 8, further comprising: the slide, the lower surface of slide is provided with an at least spout, one side of base with the lower extreme fixed connection of support, the other side of base extends to the below of supporting part, just the upper surface of the opposite side of base sets up an at least draw runner, the spout with the draw runner phase-match, still be provided with a plurality of spacing buckles on the slide, it is a plurality of spacing buckle be used for with the laboratory animal is fixed in the upper surface of slide, the slide bears the laboratory animal pass through the spout with the matching of draw runner slides in the support below of supporting part makes the head of laboratory animal is just to opening setting down.

Technical Field

The invention relates to the technical field of transcranial magnetic stimulation, in particular to a TMS intervention device for animals.

Background

Transcranial Magnetic Stimulation (TMS) is an emerging neurostimulation technology, and is known as the four-brain science technology of the 21 st century together with PET technology, FMRI technology and MEG technology. TMS technology is mainly used to stimulate or inhibit local cerebral cortex function by changing the stimulation frequency, and to treat diseases by bi-directionally regulating the balance between the cerebral stimulation and inhibition. In practice, the stimulation is not limited to the stimulation of the brain, and peripheral nerve muscles can be stimulated. At present, when a magnetic head for human TMS intervention is used for animal TMS intervention, animals such as mice are not suitable for direct experiment, and because the magnetic head for accommodating the magnetic stimulation coil of the TMS device is too large for the mice, experimental data is often inaccurate, and reasonable and convenient operation is difficult to perform.

Disclosure of Invention

In view of the above, in order to solve the above problems, the present invention provides a TMS intervention device for animals, comprising: the TMS device comprises a TMS device, an installation part, a turntable part and a support part, wherein the TMS device at least comprises a magnetic stimulation coil, the mounting part is arranged right above the turntable part, the turntable part is rotatably arranged on the supporting part, the magnetic stimulation coil is arranged on the mounting part, at least two limiting holes are sequentially arranged on the turntable part along the annular direction, the supporting part is provided with a lower through hole, the inner diameter of one limiting hole is larger than that of the other limiting hole, each limiting hole is operably arranged opposite to one lower through hole, the inner diameter of the limiting hole is equal to or less than that of the lower port, an experimental animal is placed below the lower port, the magnetic stimulation coil downwards generates a pulse magnetic field, and the pulse magnetic field sequentially penetrates through one of the limiting holes and the lower through opening to intervene the experimental animal.

In another preferred embodiment, the magnetic stimulation coil is disposed at the upper end of the mounting portion, an upper opening is disposed on the mounting portion, and the pulsed magnetic field operably passes through the upper opening, one of the limiting holes and the lower opening from top to bottom in sequence.

In another preferred embodiment, the inner diameter of the upper port and the inner diameter of the lower port are equal.

In another preferred embodiment, the turntable part is made of a ferromagnetic material, and the turntable part is of an iron plate structure.

In another preferred embodiment, the turntable part and the support part are both made of ferromagnetic material.

In another preferred embodiment, the TMS device further comprises: the equipment main part passes through the connecting wire with the magnetic stimulation coil is connected, the installation cover is located the magnetic stimulation coil is close to one of connecting wire is served.

In another preferred embodiment, one side of the upper surface of the installation part is provided with a clamping piece, a clamping groove is formed in the clamping piece, the clamping groove is matched with the installation sleeve, and the magnetic stimulation coil is fixedly installed on the installation part through the clamping groove and the clamping of the installation sleeve.

In another preferred embodiment, the method further comprises: the support is arranged in the vertical direction, the base is fixedly installed at the lower end of the support, the lower surface of the base is provided with a friction enhancing structure, the installation part is installed on the upper portion of the support, and the supporting part is fixedly installed on the lower portion of the support.

In another preferred embodiment, the stent is a telescopic structure, the stent comprising: the supporting part comprises a lower supporting leg and an upper supporting leg, the upper supporting leg is connected with the lower supporting leg in a sliding mode along the vertical direction, the mounting part is fixedly connected with the upper supporting leg, and the supporting part is fixedly connected with the lower supporting leg.

In another preferred embodiment, the method further comprises: the slide, the lower surface of slide is provided with an at least spout, one side of base with the lower extreme fixed connection of support, the other side of base extends to the below of supporting part, just the upper surface of the opposite side of base sets up an at least draw runner, the spout with the draw runner phase-match, still be provided with a plurality of spacing buckles on the slide, it is a plurality of spacing buckle be used for with the laboratory animal is fixed in the upper surface of slide, the slide bears the laboratory animal pass through the spout with the matching of draw runner slides in the support below of supporting part makes the head of laboratory animal is just to opening setting down.

Due to the adoption of the technical scheme, compared with the prior art, the invention has the following positive effects: by applying the invention, the range of the pulse magnetic field, namely the magnetic line of force, generated by the magnetic stimulation coil is properly adjusted through the turntable part and the corresponding limiting hole, and the distance between the magnetic stimulation coil and the experimental animal can be adjusted; therefore, the reasonable and controllable transcranial magnetic stimulation experiment can be carried out on experimental animals, such as small animals with the same volume as a mouse, the accurate regulation and control of TMS equipment output are realized, and the experimenter can conveniently carry out efficient experiment operation.

Drawings

Fig. 1 is a schematic view of a TMS intervention device for animals in accordance with the present invention;

fig. 2 is a reference diagram for use of a TMS intervention device for animals in accordance with the present invention;

fig. 3 is a matching view of a turntable support part of the TMS intervention device for animals of the present invention.

In the drawings:

1. TMS equipment; 2. an installation part; 3. a turntable part; 4. a support portion; 11. a magnetic stimulation coil; 31. a limiting aperture; 41. a lower port; 21. an upper port; 12. a connecting wire; 13. installing a sleeve; 22. a fastener; 5. a support; 6. a base; 51. a lower leg; 52. an upper support leg; 53. screwing the bolt; 54. a pull ring; 61. a slide plate; 62. a slide bar; 63. a limit buckle; 42. an antibacterial film; 7. a mouse; 71. the brain.

Detailed Description

The invention is further described with reference to the following drawings and specific examples, which are not intended to be limiting.

As shown in fig. 1 to 3, there is shown a TMS intervention device for animals, comprising: TMS equipment 1, installation department 2, carousel portion 3 and supporting part 4, TMS equipment 1 includes a magnetic stimulation coil 11 at least, installation department 2 sets up directly over carousel portion 3, carousel portion 3 rotationally sets up on supporting part 4, magnetic stimulation coil 11 installs on installation department 2, carousel portion 3 is gone up and is followed the hoop and has set gradually two at least restriction holes 31, be provided with opening 41 once on the supporting part 4, the internal diameter of a restriction hole 31 is greater than the internal diameter of another restriction hole 31, each restriction hole 31 all is operable to just setting up opening 41 once, and the internal diameter of this restriction hole 31 equals or is less than the internal diameter of opening 41 down, laboratory animal has been placed to the below of opening 41 down, magnetic stimulation coil 11 produces downwards has a pulsed magnetic field, pulsed magnetic field passes one of them restriction hole 31 and opening 41 down in proper order and intervenes laboratory animal. Further, the matching rotation of the turntable part 3 and the support part 4 and the alignment of the lower through hole 41 and the limiting hole 31 form a regulating structure similar to a microscope between a light through hole and an aperture, the limiting holes 31 with different sizes are opposite to the lower through hole 41 by rotating the rotating part, so that the horizontal range of the pulsed magnetic field generated by the magnetic stimulation coil 11 when acting on the experimental animal is limited, namely the magnetic line of force of the magnetic stimulation coil 11 is limited, and the reasonable and controllable transcranial magnetic stimulation experiment is carried out on the experimental animal, such as a small animal with the same volume of a mouse 7.

Further, as a preferred embodiment, the magnetic stimulation coil 11 is 8-shaped or circular.

Further, as a preferred embodiment, the mounting portion 2, the turntable portion 3, and the supporting portion 4 are all plate-shaped structures, and the mounting portion 2, the turntable portion 3, and the supporting portion 4 are disposed in parallel.

Further, as a preferred embodiment, the outer edge of the turntable part 3 is provided with friction enhancing lines for experiment operators to rotate the turntable part 3.

Further, as a preferred embodiment, the outer edge of the turntable part 3 is provided with a protruding block for the experiment operator to rotate the turntable part 3.

Further, as a preferred embodiment, the turntable part 3 is rotatably connected to the supporting part 4 through a rotating shaft.

Further, as a preferred embodiment, the number of the limiting holes 31 on the turntable unit 3 is not limited, the turntable units 3 with the limiting holes 31 of different specifications may be provided according to specific needs, the number of the limiting holes 31 may be greater than or equal to two, and the inner diameter of each limiting hole 31 is different.

Further, as a preferred embodiment, the magnetic stimulation coil 11 is disposed at the upper end of the mounting portion 2, the mounting portion 2 is provided with an upper through opening 21, and the pulsed magnetic field operably passes through the upper through opening 21, one of the limiting holes 31 and the lower through opening 41 from the top to the bottom.

Further, as a preferred embodiment, the inner diameter of the upper through opening 21 is equal to the inner diameter of the lower through opening 41.

Further, as a preferred embodiment, the turntable 3 is made of a ferromagnetic material, and the turntable 3 is an iron plate.

Further, as a preferred embodiment, the turntable unit 3 and the support unit 4 are made of ferromagnetic material.

Further, as a preferred embodiment, the TMS device 1 further comprises: the equipment host computer, connecting wire 12, installation cover 13, the equipment main part passes through connecting wire 12 and is connected with magnetic stimulation coil 11, and installation cover 13 cover is located magnetic stimulation coil 11 and is close to one end of connecting wire 12 on.

Further, as a preferred embodiment, the magnetic stimulation coil 11 includes: the magnetic head comprises a magnetic head and a coil body, wherein the coil body is fixedly arranged in the magnetic head, a connecting wire 12 is connected with the coil body, and an installation sleeve 13 is fixedly connected with the magnetic head.

Further, as a preferred embodiment, the outer edge of the turntable part 3 is provided with a plurality of first position marks, each of the first position marks is disposed adjacent to one of the limiting holes 31, the outer edge of the support part 4 is provided with a second position mark, any one of the first position marks is operatively aligned with the second position mark, and when the one of the first position marks is aligned with the second position mark, the corresponding one of the limiting holes 31 is disposed in alignment with the lower through opening 41.

Further, as a preferred embodiment, one side of the upper surface of the mounting portion 2 is provided with a clamping piece 22, a clamping groove is formed on the clamping piece 22, the clamping groove is matched with the mounting sleeve 13, and the magnetic stimulation coil 11 is fixedly mounted on the mounting portion 2 through the clamping of the clamping groove and the mounting sleeve 13.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope and the implementation manner of the present invention.

The present invention also has the following embodiments in addition to the above:

in a further embodiment of the present invention, the method further comprises: support 5 and base 6, support 5 sets up along vertical direction, and base 6 fixed mounting has the friction enhancement structure in the lower extreme of support 5, 6 lower surfaces of base, and installation department 2 installs in the upper portion of support 5, and supporting part 4 fixed mounting is in the lower part of support 5.

In a further embodiment of the present invention, the support 5 is a telescopic structure, and the support 5 comprises: the support part comprises a lower leg 51 and an upper leg 52, wherein the upper leg 52 is connected with the lower leg 51 in a sliding mode along the vertical direction, the mounting part 2 is fixedly connected with the upper leg 52, and the support part 4 is fixedly connected with the lower leg 51.

In a further embodiment of the present invention, the lower leg 51 is a hollow structure with an upward opening, the lower end of the upper leg 52 is slidably sleeved in the lower leg 51 up and down, the outer wall of the lower portion of the upper leg 52 is sequentially provided with a plurality of limiting recesses along the vertical direction, the lower leg 51 is provided with a tightening bolt 53, and the tightening bolt 53 is used for abutting against one limiting recess of the upper leg 52 so as to make the upper leg 52 and the lower leg 51 form a limiting fixation in the vertical direction.

In a further embodiment of the invention, the upper leg 52 is provided at its upper end with a pull ring 54, which pull ring 54 is adapted to lift the upper leg 52 for vertical displacement relative to the lower leg 51.

In a further embodiment of the present invention, the method further comprises: slide 61, slide 61's lower surface is provided with an at least spout, one side of base 6 and support 5's lower extreme fixed connection, the other side of base 6 extends to the below of supporting part 4, and the upper surface of the opposite side of base 6 sets up an at least draw runner 62, spout and draw runner 62 phase-match, still be provided with a plurality of spacing buckles 63 on the slide 61, a plurality of spacing buckles 63 are used for being fixed in the upper surface of slide 61 with experimental animal like mouse 7, slide 61 bears experimental animal and slides in supporting part 4's support below and makes experimental animal's brain 71 just to opening 41 setting down through spout and draw runner 62's matching.

In a further embodiment of the present invention, the upper surface of the sliding plate 61 is provided with five position-limiting buckles 63, the five position-limiting buckles 63 are respectively and operatively tightened on the limbs and the neck of the experimental animal, one end of each position-limiting buckle 63 is fixedly connected with the sliding plate 61, and the other end of each position-limiting buckle 63 is operatively connected with the sliding plate 61 through a screw or a bolt, etc.

In a further embodiment of the invention, the support 4 may be made of a light material.

In a further embodiment of the present invention, the lower surface of the support 4 is provided with a layer of antimicrobial film 42.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention.