阅读说明：本技术 皮肤状况改善药剂 (Skin condition improving agent ) 是由 格哈德·施毛斯 扎比内·朗格 保罗·斯拉瓦舍维奇 于 2019-03-25 设计创作，主要内容包括：本发明涉及一种组合物,优选在用于改善或预防一种或多种不良皮肤状况的治疗方法中使用。此外,本发明涉及一种包括这种组合物的化妆品和/或皮肤病学制剂。(The present invention relates to a composition, preferably for use in a method of treatment for ameliorating or preventing one or more adverse skin conditions. Furthermore, the invention relates to a cosmetic and/or dermatological preparation comprising such a composition.)

1. A composition, comprising:

a) one, two, three or more avenanthramides of formula (I),

wherein the content of the first and second substances,

m is 0, 1, 2 or 3,

p is 0, 1 or 2,

n is 0, 1 or 2,

it is assumed that if n is 1 or 2, then the sum (p + m) > 0,

wherein if n is 1 or 2, then R¹And R²Both are H or together form another chemical bond,

wherein if m is 1, 2 or 3, each X is independent of the other OH, O-alkyl or O-acyl groups,

wherein if p is 1 or 2, then each Y is independent of the other OH, O-alkyl or O-acyl,

provided that if (p + m) > 0, then X or Y is at least once selected from the group consisting of OH and O-acyl,

wherein R is³Either of (a) H, N or an alkyl group,

and/or according to formula (II): r¹(OCH₂CHR²)_nOR³One, two, three or more polyalkylene glycol derivatives of (a),

wherein the content of the first and second substances,

R¹represents hydrogen or a linear or branched alkyl group having 1 to 4 carbon atoms,

R²represents hydrogen or a methyl group,

n represents an integer from 3 to 20,

R³represents a compound having 6 to 18 carbon atoms and 0, 1, 2 or 3 double bonds or-COR⁴Straight or branched alkyl or alkenyl of acyl, and

R⁴represents hydrogen, a linear or branched alkyl or alkenyl group having from 5 to 17 carbon atoms, or an alkali metal, alkaline earth metal or NH₃，

And, optionally,

b) the oil body is a mixture of oil and water,

wherein the content of the first and second substances,

if present, the ratio of the total amount of avenanthramides(s) to the total amount of polyalkylene glycol derivative(s) in the composition is in the range of from 10: 1 to 1: 1000, preferably in the range of from 1: 1 to 1: 100, particularly preferably in the range of from 1: 2 to 1: 50, especially preferably in the range of from 1: 5 to 1: 25, by weight.

2. The composition according to claim 1, wherein component a) consists of one, two, three or more avenanthramides of formula (I) and of one, two, three or more polyalkylene glycol derivatives of formula (II).

3. The composition of any one of claims 1 or 2, wherein one or the, two, three or more polyalkylene glycol derivatives are or respectively comprise: (ii) a polyethylene glycol ester(s), preferably wherein the number of C atoms of the polyethylene glycol moiety is from 3 to 7 and/or the number of C atoms of the ester moiety is from 3 to 5; and/or polyethylene glycol ether(s), preferably wherein the number of C atoms of the polyethylene glycol moiety is from 7 to 11 and/or the number of C atoms of the ether moiety is from 11 to 15.

4. Composition according to any one of claims 1 to 3, in which component a) consists of one avenanthramide of formula (I) and of two polyalkylene glycol derivatives of formula (II).

5. The composition according to any one of claims 1 to 4, wherein component a) consists of one avenanthramide of formula (I) and two polyalkylene glycol derivatives of formula (II), wherein the two polyalkylene glycol derivatives are one PEG ester and one PEG ether.

6. Composition according to any one of claims 1 to 5, wherein one or the avenanthramides, if present, is dihydroavenanthramide D and/or wherein one or more or all polyalkylene glycol derivatives, if present, is or respectively comprise trideceth-9 and/or eth-laureth.

7. The composition according to any one of claims 1 to 6, wherein the one, two or all polyalkylene glycol derivatives are selected from the group consisting of PEG-5 ethylhexanoate, trideceth-9 and PEG-5-3, 5, 5-trimethylhexanoate.

8. Composition according to any one of the preceding claims, wherein the total amount of components a) and/or b) in the composition, if present, is sufficient to ameliorate or prevent one or more adverse skin conditions, wherein the adverse skin condition(s) is preferably one, two or more conditions selected from the group consisting of exfoliation, lichenification and scaling associated with dry skin.

9. Composition for use in a method of treatment according to any one of the preceding claims for ameliorating or preventing one or more adverse skin conditions, wherein the adverse skin condition(s) is preferably one, two or more conditions selected from the group consisting of exfoliation, lichenification and scaling associated with dry skin.

10. A cosmetic and/or dermatological preparation comprising a composition according to any one of claims 1 to 8, wherein the composition is present in a total amount sufficient to ameliorate or prevent one or more adverse skin conditions, preferably one, two or more conditions selected from the group consisting of exfoliation, lichenification and scaling associated with dry skin.

11. The cosmetic and/or dermatological formulation according to claim 10, wherein the formulation is an oil-in-water (o/w) emulsion, preferably a biphasic system of an oil-in-water or shampoo.

12. The cosmetic and/or dermatological formulation according to claim 10 or claim 11, wherein the total amount of polyalkylene glycol derivative(s), if present, is from 0.1 to 5.0% by weight of the formulation, preferably from 0.5 to 2.5% by weight of the formulation.

13. The cosmetic and/or dermatological formulation according to any one of claims 10 to 12, wherein the total amount of avenanthramides(s), if present, is from 0.005 to 1.0% by weight of the formulation, preferably from 0.01 to 1.0% by weight of the formulation, preferably from 0.05 to 1.0% by weight of the formulation, preferably from 0.005 to 0.20% by weight of the formulation, preferably from 0.01 to 0.20% by weight of the formulation, from 0.02 to 0.20% by weight of the formulation.

14. The cosmetic and/or dermatological formulation according to any one of claims 10 to 13, wherein the formulation further comprises one or more moderately water-soluble active ingredients selected from the group consisting of: odoriferous substances, perfume oils, aromatic substances, fragrances, fatty oils, fatty acids, waxes, ceramides, pseudoceramides, sterols, phytosterols, anti-acne actives, anti-dandruff actives, antibacterial actives, preservatives, antiperspirants, anti-irritants, actives to relieve itching, cooling actives, antioxidants, UV filters, anti-aging actives, actives to whiten and tan skin, skin moisture regulators, osmolytes, insect repellents, enzyme inhibitors, odor absorbers, dyes.

15. The cosmetic and/or dermatological formulation according to any one of claims 10 to 14, for use in a treatment method for improving or preventing one or more adverse skin conditions, wherein the adverse skin condition(s) is preferably one, two or more conditions selected from the group consisting of exfoliation, lichenification and scaling associated with dry skin.

Technical Field

The present invention relates to a composition comprising avenanthramide(s) and/or polyalkylene glycol derivative(s) and oil bodies. One aspect of the present invention relates to such compositions for use in a method of treatment for ameliorating or preventing one or more adverse skin conditions. The invention further relates to a cosmetic and/or dermatological preparation comprising such a composition.

Background

Several skin disorders and skin aging are associated with thin, dry skin that exhibits enhanced and undesirable clinical symptoms such as excoriation, lichenification and scaling.

Exfoliation may often be caused by exfoliation in the case of acne in puberty or the onset of other skin conditions such as peritrichopathies, psoriasis and eczema. Exfoliation describes several skin lesions or abrasions caused by, for example, excessive skin grooming.

Lichenification describes a skin condition that includes epidermal thickening, which is generally characterized by visible and tactile thickening of the skin. Often, significant skin marks and/or exaggerated lines of normal skin appear.

Scales describe abnormal shedding or accumulation of the upper layers of the skin (stratum corneum). Scales are often associated with dry skin conditions.

The skin may, for example, tend to produce scales because it is too dry. The physiological mechanism used to prevent scaling by moisturizing the skin is the production of oil. However, with age, use of, for example, soaps, shampoos, perfumes, or disinfectants, exposure to hot water, and dry air conditions, such as those caused by room heating, the skin may become dry and rough and begin to develop scales. In general, substances that cause defatting or degreasing and thus cause skin dryness appear to promote the development of undesirable clinical symptoms such as, for example, exfoliation, lichenification, and dry skin (e.g., scales).

WO 2016/207084a1 describes the use of polyethylene glycol esters and/or polyethylene glycol ethers for the treatment of pruritic conditions of the skin and scalp.

US 2010/150854a1 describes cosmetic and/or dermatological preparations containing polyethylene glycol esters and/or polyethylene glycol ethers for moisturizing the skin and for delaying or preventing the drying out of the skin.

DE 10254872 a1 relates to the use of anthranilic acid amides as cosmetic preparations for inhibiting substance P-induced histamine release. Reducing histamine release is said to improve skin itch, pain, and skin redness.

Disclosure of Invention

However, other substances and cosmetic and/or dermatological preparations are sought which have an increased effectiveness in improving or preventing adverse skin conditions.

In the search for suitable medicaments, it must be taken into account that the substances used should be toxicologically acceptable, well tolerated and stable on the skin (in particular in conventional cosmetic and/or dermatological formulations), and that the substances used should preferably have the lowest possible intrinsic odour and the lowest possible intrinsic colour and be inexpensive to produce.

It is therefore an object of the present invention to develop a stable, cost-effective product with skin condition improving properties. Such skin conditions preferably include or consist of exfoliation, bryoid and scaling associated with dry skin.

The above-described objects are solved by a composition according to the present invention comprising:

a) one, two, three or more avenanthramides of formula (I),

wherein the content of the first and second substances,

m is 0, 1, 2 or 3,

p is 0, 1 or 2,

n is 0, 1 or 2,

it is assumed that if n is 1 or 2, then the sum (p + m) > 0,

wherein if n is 1 or 2, then R¹And R²Both are H or together form another chemical bond,

wherein if m is 1, 2 or 3, each X is independent of the other OH, O-alkyl or O-acyl groups,

wherein if p is 1 or 2, then each Y is independent of the other OH, O-alkyl or O-acyl,

provided that if (p + m) > 0, then X or Y is at least once selected from the group consisting of OH and O-acyl,

wherein R is³Either of (a) H, N or an alkyl group,

and/or according to formula (II): r¹(OCH₂CHR²)_nOR³One, two, three or more polyalkylene glycol derivatives of (a),

wherein the content of the first and second substances,

R¹represents hydrogen or a linear or branched alkyl group having 1 to 4 carbon atoms,

R²represents hydrogen or a methyl group,

n represents an integer from 3 to 20,

R³represents a compound having 6 to 18 carbon atoms and 0, 1, 2 or 3 double bonds or-COR⁴Straight or branched alkyl or alkenyl of acyl, and

R⁴represents hydrogen, a linear or branched alkyl or alkenyl group having from 5 to 17 carbon atoms, or an alkali metal, alkaline earth metal or NH₃，

And, optionally,

b) the oil body is a mixture of oil and water,

wherein the content of the first and second substances,

if present, the ratio of the total amount of avenanthramides(s) to the total amount of polyalkylene glycol derivative(s) in the composition is in the range of from 10: 1 to 1: 1000, preferably in the range of from 1: 1 to 1: 100, particularly preferably in the range of from 1: 2 to 1: 50, especially preferably in the range of from 1: 5 to 1: 25, by weight.

The one, two, three or more avenanthramides of formula (I) in the composition according to the invention preferably or respectively comprise one or two avenanthramides selected from the group consisting of avenanthramide A, B, C, D and dihydroavenanthramide A, B, C, D.

The one, two, three or more polyalkylene glycol derivatives of the formula (II) in the composition according to the invention preferably or respectively comprise one, two, three or more polyalkylene glycol derivatives according to the formula (IIa),

H(OCH₂CH₂)_nOR³(IIa)

wherein n represents an integer from 7 to 12, and R³Represents a linear or branched alkyl group having 8 to 15 carbon atoms,

and/or preferably one, two, three or more polyalkylene glycol derivatives according to formula (IIb),

H(OCH₂CH₂)_nO-COR⁴(IIb)

wherein n represents an integer from 3 to 7, and R⁴Represents a linear or branched alkyl group having 7 to 11 carbon atoms.

The one, two, three or more polyalkylene glycol derivatives of formula (II) and/or (IIa) and/or (IIb) in the composition according to the invention preferably or respectively comprise one, two, three or more polyethylene glycol (PEG) ethers of formula (IIa) and/or one, two, three or more polyethylene glycol (PEG) esters of formula (IIb).

Polyglycol ethers according to formula (II) and/or (IIa) which can be used in the composition are, for example, PEG-7 octyl ether, PEG-7 nonyl ether, PEG-7 decyl ether, PEG-7 undecyl ether, PEG-7 dodecyl ether, PEG-7 tridecyl ether, PEG-7 tetradecyl ether, PEG-8 octyl ether, PEG-8 nonyl ether, PEG-8 decyl ether, PEG-8 undecyl ether, PEG-8 dodecyl ether, PEG-8 tridecyl ether, PEG-8 tetradecyl ether, PEG-9 octyl ether, PEG-9 nonyl ether, PEG-9 decyl ether, PEG-9 undecyl ether, PEG-9 dodecyl ether, PEG-9 tridecyl ether, PEG-9 tetradecyl ether, PEG-10 octyl ether, PEG-10 nonyl ether, PEG-10 decyl ether, PEG-10 undecyl ether, PEG-10 dodecyl ether, PEG-10 tridecyl ether, PEG-10 tetradecyl ether, PEG-11 octyl ether, PEG-11 nonyl ether, PEG-11 decyl ether, PEG-11 undecyl ether, PEG-11 dodecyl ether, PEG-11 tridecyl ether, PEG-11 tetradecyl ether, PEG-12 octyl ether, PEG-12 nonyl ether, PEG-12 decyl ether, PEG-12 undecyl ether, PEG-12 dodecyl ether, PEG-12 tridecyl ether, PEG-12 tetradecyl ether.

Preferably, the PEG ether or one or both of the PEG ethers in the composition according to the invention is trideceth-9 (PEG-9 trideceth) and/or laureth-9 (laureth 9).

Polyethylene glycol esters which can be used in the compositions according to formula (II) and/or (IIb) are, for example, PEG-3 octanoate, PEG-3 nonanoate, PEG-3 isononanoate, PEG-3 decanoate, PEG-3 undecanoate, PEG-3 dodecanoate, PEG-4 octanoate, PEG-4 nonanoate, PEG-4 isononanoate, PEG-4 decanoate, PEG-4 undecanoate, PEG-4 dodecanoate, PEG-5 ethylhexanoate, PEG-53, 5, 5-trimethylhexanoate, PEG-5 octanoate, PEG-5 nonanoate, PEG-5 isononanoate, PEG-5 decanoate, PEG-5 undecanoate, PEG-5 dodecanoate, PEG-6 octanoate, PEG-6 nonanoate, PEG-6 isononanoate, PEG-6 decanoate, PEG-6 undecanoate, PEG-6 dodecanoate, PEG-7 octanoate, PEG-7 nonanoate, PEG-7 isononanoate, PEG-7 decanoate, PEG-7 undecanoate, or PEG-7 dodecanoate.

Preferably, the PEG ester or one or both of the PEG esters in the composition according to the invention is PEG-5 ethylhexanoate and/or PEG-53, 5, 5-trimethylhexanoate.

It is further preferred that the one, two, three or more polyalkylene glycol derivatives are or comprise respectively one, two or all polyalkylene glycol derivatives selected from the group consisting of PEG-5 ethylhexanoate, trideceth-9 and PEG-5-3, 5, 5-trimethylhexanoate.

The oil bodies which can be used in the composition according to the invention are, for example, Guerbet alcohols based on fatty alcohols having from 6 to 18, preferably from 8 to 10, carbon atoms, esters of linear C6-C22 fatty acids with linear or branched C6-C22 fatty alcohols or esters of branched C6-C13 carboxylic acids with linear or branched C6-C22 fatty alcohols, such as, for example, myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, stearyl isostearate, Stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, erucic acid behenate, erucyl myristate, erucyl palmitate, erucyl stearate, isostearyl isostearate, erucyl oleate, erucyl palmitate, erucyl stearate, erucyl oleate, erucyl palmitate, erucyl stearate, erucyl oleate, erucyl behenyl behenate, and erucyl. Also suitable are esters of linear C6-C22 fatty acids with branched alcohols, in particular 2-ethylhexanol, esters of C18-C38 alkylhydroxycarboxylic acids with linear or branched C6-C22 fatty alcohols, in particular dioctyl malate, esters of linear and/or branched fatty acids with polyhydric alcohols, such as, for example, propylene glycol, dimer diol or trimer triol, and/or Guerbet alcohols, triglycerides based on C6-C10 fatty acids, liquid mono/di/triglyceride mixtures based on C6-C18 fatty acids, fatty acid esters of glycerol, glycerol,Esters of C6-C22 fatty alcohols and/or Guerbet alcohols with aromatic carboxylic acids, in particular benzoic acid, esters of C2-C12 dicarboxylic acids with linear or branched alcohols having from 1 to 22 carbon atoms or polyols having from 2 to 10 carbon atoms and from 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, linear and branched C6-C22 fatty alcohol carbonates (such as, for example, dioctyl carbonate (s)) (benzoic acid)

C) Esters based on Guerbet carbonates of aliphatic alcohols having 6 to 18, preferably 8 to 10, carbon atoms, benzoic acid and straight-chain and/or branched C6-C22 alcohols (e.g. methanol, ethanol

TN), straight-chain or branched symmetrical or asymmetrical dialkyl ethers having 6 to 22 carbon atoms per alkyl group (such as, for example, dioctyl ether: (n) ((n))OE)), ring-opening products of epoxidized fatty acid esters with polyols, silicone oils (cyclomethicone, silicone methicone grades, etc.) and/or esters of aliphatic or cycloalkanes such as, for example, squalane, squalene or dialkylcyclohexane.

In one embodiment of the invention, component a) of the composition according to the invention consists of one, two, three or more avenanthramides of formula (I).

In this respect, component a) preferably consists of a different avenanthramide. Unless otherwise stated, the features also apply to the following paragraphs.

In case several different avenanthramides are present in the composition, the weight ratio of avenanthramide with the highest weight ratio to one or all other avenanthramides is preferably from 10: 1 to 1: 10, preferably more than 1: 1; more preferably from 5: 1 to 1: 5, preferably greater than 1: 1; particularly preferably from 2: 1 to 1: 2, preferably greater than 1: 1.

In another embodiment of the invention, component a) of the composition according to the invention consists of one, two, three or more polyalkylene glycol derivatives of formula (II), wherein preferably the one, two, three or more polyalkylene glycol derivatives of formula (II) preferably or respectively comprise one, two, three or more polyalkylene glycol derivatives according to formula (IIa) and/or formula (IIb).

In a preferred embodiment of the invention, component a) of the composition according to the invention consists of one, two, three or more polyethylene glycol derivatives of the formula (II), preferably of one, two, three or more polyethylene glycol ethers of the formula (IIa) and one, two, three or more polyethylene glycol esters of the formula (IIb), particularly preferably of one polyethylene glycol ether of the formula (IIa) and one polyethylene glycol ester of the formula (IIb).

In case several different polyalkylene glycol derivatives are present in the composition, the weight ratio of the polyalkylene glycol derivative having the highest weight ratio to one or all other polyalkylene glycol derivatives is preferably from 10: 1 to 1: 10, preferably more than 1: 1; more preferably from 5: 1 to 1: 5, preferably greater than 1: 1; particularly preferably from 2: 1 to 1: 2, preferably greater than 1: 1.

In case several different polyethylene glycol derivatives, several different polyethylene glycol ethers and/or several different polyethylene glycol esters are present in the composition, said ratios apply accordingly and are also preferred.

In another embodiment of the invention, component a) of the composition according to the invention consists of one, two, three or more avenanthramides of formula (I) and of one, two, three or more polyalkylene glycol derivatives of formula (II), preferably of formula (IIa) and/or formula (IIb).

It is particularly preferred that component a) consists of one avenanthramide of formula (I) and of two polyalkylene glycol derivatives of formula (II).

Furthermore, it is especially preferred that component a) consists of an avenanthramide of formula (I), a PEG ester and a PEG ether, preferably wherein,

in the PEG ester, the number of C atoms of the polyethylene glycol moiety is from 3 to 7 and/or the number of C atoms of the ester moiety is from 3 to 5,

and/or

In the PEG ether, the number of C atoms of the polyethylene glycol moiety is from 7 to 11 and/or the number of C atoms of the ether moiety is from 11 to 15.

Preferably, one, two or all polyalkylene glycol derivatives are selected from the group consisting of PEG-5 ethylhexanoate, trideceth-9, and PEG-5-3, 5, 5-trimethylhexanoate.

It is particularly preferred that component a) comprises or consists of dihydroavenanthramide D, trideceth-9 and PEG-5 ethylhexanoate.

As described above, the avenanthramide(s) may be a different or several different avenanthramides, and/or the polyalkylene glycol derivative may be a different or several different polyethylene glycol ether of formula (IIa) and/or a different or several different polyethylene glycol ester of formula (IIb). In this respect, component a) preferably consists of a different avenanthramide, a different polyethylene glycol ester and/or a different polyethylene glycol ether. Unless otherwise stated, the features also apply to the following paragraphs.

In another embodiment of the invention, one or said, two, three or more polyalkylene glycol derivatives of the composition according to the invention are or respectively comprise: (ii) a polyethylene glycol ester(s), preferably wherein the number of C atoms of the polyethylene glycol moiety is from 3 to 7 and/or the number of C atoms of the ester moiety is from 3 to 5; and/or polyethylene glycol ether(s), preferably wherein the number of C atoms of the polyethylene glycol moiety is from 7 to 11 and/or the number of C atoms of the ether moiety is from 11 to 15.

The term "polyethylene glycol moiety" of an ester or ether is intended to be understood as a moiety derived from a polyethylene glycol ester or ether of polyethylene glycol.

The term "ester moiety" is intended to be understood as an acid-derived moiety of a polyethylene glycol ester, which moiety forms an ester bond with polyethylene glycol, thereby yielding the corresponding polyethylene glycol ester.

The term "ether moiety" is intended to be understood as a moiety of a polyethylene glycol ether derived from a compound which forms an ester bond with the polyethylene glycol, thereby yielding the corresponding polyethylene glycol ether. In another embodiment of the present invention, one or said avenanthramides, if present, is dihydroavenanthramide D and/or, if present, said one or more or all polyalkylene glycol derivatives are or comprise trideceth-9 and/or laureth-yl respectively.

In a preferred embodiment of the invention, component a) comprises or consists of dihydroavenanthramide D and trideceth-9.

In a preferred embodiment of the invention, component a) consists of dihydroavenanthramide D and trideceth-9.

In a preferred embodiment of the invention, component a) comprises or consists of dihydroavenanthramide D and laureth-oxy.

In a preferred embodiment of the invention, component a) consists of dihydroavenanthramide D and laureth oxide.

In another embodiment of the present invention, the one, two, three or more polyalkylene glycol derivatives are or respectively comprise one, two or all polyalkylene glycol derivatives selected from the group consisting of PEG-5 ethylhexanoate, trideceth-9, and PEG-5-3, 5, 5-trimethylhexanoate.

In one embodiment of the invention, the total amount of components a) and/or b) in the composition, if present, is sufficient to ameliorate or prevent one or more adverse skin condition(s), wherein the adverse skin condition(s) is preferably one, two or more conditions selected from the group consisting of exfoliation, lichenification and scaling associated with dry skin.

For the purposes of the present invention, "skin" is in particular an organ which covers the outside of the human body and is composed of the epidermis, the dermis and the subcutaneous tissue. Preferably, for the purposes of the present invention, the lining and/or covering of internal organs (e.g. mucosa, periosteum, vascular tissue and retina) is not "skin".

The presence of polyalkylene glycol ester(s), particularly polyethylene glycol ester(s) and polyethylene glycol ether(s), in such compositions unexpectedly demonstrates a reduction in clinical symptoms associated with dry skin, such as scaling, exfoliation and lichenification (see example 2).

Even more surprisingly, the combination of avenanthramides (one or more) with polyalkylene glycol ester(s), particularly polyethylene glycol ester(s) and polyethylene glycol ether(s), in such a composition exhibits enhanced reduction of clinical symptoms associated with dry skin, such as scaling, exfoliation and lichenification (see example 3), although such effects have never been described to date for avenanthramides.

In another embodiment of the invention, the composition according to the invention may be used in a method of treatment for improving or preventing one or more adverse skin conditions, wherein the adverse skin condition(s) is preferably one, two or more conditions selected from the group consisting of exfoliation, lichenification and scaling associated with dry skin.

Another aspect of the invention relates to a cosmetic and/or dermatological preparation comprising a composition according to the invention, wherein such composition is present in a total amount sufficient to ameliorate or prevent one or more adverse skin conditions, wherein the adverse skin condition(s) is preferably one, two or more conditions selected from the group consisting of exfoliation, mossy and scaling associated with dry skin.

The "cosmetic" formulations used for the purposes of the present invention are in particular formulations suitable for topical application to the skin of humans, in particular for achieving a cosmetic effect. A "dermatological formulation" is a formulation suitable for topical application to the skin of a human to achieve a pharmaceutical effect, in particular to alleviate or cure a disease, especially a skin disease.

It has also been found, surprisingly, that the compositions according to the invention containing polyalkylene glycol derivative(s) have excellent compatibilising properties with respect to other lipophilic substances or substance mixtures which are only moderately water-soluble, such as, for example, perfume oils, anti-dandruff agents, anti-acne agents or substances which regenerate the skin barrier. In particular, the excellent solubility-mediating properties of the compositions according to the invention with respect to other active ingredients (such as, for example, fatty oils, fatty acids, ceramides, pseudoceramides, sterols, phytosterols or hydrocarbons) ideally make them suitable for use in cosmetic or dermatological medicaments for improving or preventing one or more adverse skin conditions, in particular selected from the group consisting of exfoliation, lichenification and scaling associated with dry skin.

In one embodiment of the invention, the cosmetic and/or dermatological formulation is an oil-in-water (o/w) emulsion, preferably a bi-phasic system of an oil-in-water or shampoo.

In another embodiment of the present invention, the total amount of polyalkylene glycol derivative(s) in the cosmetic and/or dermatological composition according to the invention, if present, is from 0.1 to 5.0% by weight of the formulation, preferably from 0.5 to 2.5% by weight of the formulation.

In another embodiment of the present invention, the total amount of avenanthramides(s) in the cosmetic and/or dermatological composition according to the invention, if present, is between 0.005 and 1.0% by weight of the formulation, preferably between 0.01 and 1.0% by weight of the formulation, preferably between 0.05 and 1.0% by weight of the formulation, preferably between 0.005 and 0.20% by weight of the formulation, preferably between 0.01 and 0.20% by weight of the formulation, between 0.02 and 0.20% by weight of the formulation.

In another embodiment of the present invention, the cosmetic and/or dermatological formulation further comprises one or more moderately water-soluble active ingredients selected from the group consisting of: odoriferous substances, perfume oils, aromatic substances, fragrances, fatty oils, fatty acids, waxes, ceramides, pseudoceramides, sterols, phytosterols, anti-acne actives, anti-dandruff actives, antibacterial actives, preservatives, antiperspirants, anti-irritants, actives to relieve itching, cooling actives, antioxidants, UV filters, anti-aging actives, actives to whiten and tan skin, skin moisture regulators, osmolytes, insect repellents, enzyme inhibitors, odor absorbers, dyes.

In another embodiment of the present invention, the cosmetic and/or dermatological preparation may be used in a treatment method for improving or preventing one or more adverse skin conditions, wherein the adverse skin condition(s) is preferably one, two or more conditions selected from the group consisting of exfoliation, lichenification and scaling associated with dry skin.

A compound as described herein is intended to be understood as a corresponding compound, a stereoisomer thereof and/or a corresponding salt thereof.

Preferred embodiments and further aspects of the invention can be derived from the appended patent claims and the following examples, which are not intended to limit the scope of the invention.

Detailed Description