阅读说明：本技术 一种预防和治疗酒精性肝损伤的中药复方制剂及其制备方法和用途 (Traditional Chinese medicine compound preparation for preventing and treating alcoholic liver injury and preparation method and application thereof ) 是由 陈丽 信学雷 阿吉艾克拜尔·艾萨 于 2020-08-24 设计创作，主要内容包括：本发明涉及一种预防和治疗酒精性肝损伤的中药复方制剂及其制备方法和用途,该制剂是由组分一枝蒿,茵陈,毛菊苣,玫瑰花,大黄,甘草,辅料为乳糖、糊精、淀粉、蔗糖或微晶纤维,采用粉碎,混合,加入水回流提取,过滤,浓缩至相对密度为1.0-1.2的浸膏,真空干燥,得干浸膏,粉碎得浸膏粉,加入辅料,按常规方法制成颗粒剂、胶囊剂、片剂或丸剂。该制剂具有服用方便、疗效显著的优点。经动物模型试验表明：该中药复方制剂在酒精性肝损伤疾病的预防和治疗中能发挥显著的效果。可显著降低血清肝损伤指标谷丙转氨酶、谷草转氨酶水平,对酒精性肝损伤有显著的预防和保护作用。(The invention relates to a Chinese medicinal compound preparation for preventing and treating alcoholic liver injury and its preparation method and use, the preparation is made from herba Achillea Wilsonianae, herba Artemisiae Scopariae, herba Cichorii, flos Rosae Rugosae, radix et rhizoma Rhei, licorice, and adjuvants such as lactose, dextrin, starch, sucrose or microcrystalline cellulose by pulverizing, mixing, adding water for reflux extraction, filtering, concentrating to obtain extract with relative density of 1.0-1.2, vacuum drying to obtain dry extract, pulverizing to obtain extract powder, adding adjuvants, and making into granule, capsule, tablet or pill by conventional method. The preparation has the advantages of convenient administration and good therapeutic effect. The animal model test shows that: the Chinese medicinal compound preparation can play a remarkable role in preventing and treating alcoholic liver injury diseases. Can obviously reduce the level of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase which are indexes of clear liver injury, and has obvious prevention and protection effects on alcoholic liver injury.)

1. A traditional Chinese medicine compound preparation for preventing and treating alcoholic liver injury is characterized in that: the preparation is prepared from 1000g of herba Achillea Wilsonianae as basic material, 5-60 parts of herba Artemisiae Scopariae, 5-50 parts of herba Cichorii, 5-50 parts of flos Rosae Rugosae, 5-30 parts of radix et rhizoma Rhei, 5-30 parts of Glycyrrhrizae radix, and 4-60 parts of lactose, dextrin, starch, sucrose or microcrystalline fiber as adjuvant by conventional method, and can be made into granule, capsule, tablet or pill.

2. The preparation method of the compound traditional Chinese medicine preparation for preventing and treating alcoholic liver injury according to claim 1 is characterized by comprising the following steps:

a. taking 1000g as a base number, 5-60 parts of artemisia rupestris, 5-50 parts of oriental wormwood, 5-50 parts of cichorium hirsutum, 5-50 parts of rose, 5-30 parts of rheum officinale and 5-30 parts of liquorice in parts by weight, respectively crushing into coarse powder of 20-40 meshes, mixing, adding water with the volume being 15-18 times of that of the raw material medicines, carrying out reflux extraction for 2-3 times, 2-3 hours each time, combining extracting solutions, filtering, and concentrating the filtrate at 60 ℃ under reduced pressure until the relative density is 1.1 to obtain an extract;

b. vacuum drying the extract obtained in the step a to obtain dry extract, and then crushing the dry extract and sieving the crushed dry extract with a 80-mesh sieve to obtain extract powder;

c. and (b) adding 4-60 parts of lactose, dextrin, starch, sucrose or microcrystalline cellulose serving as auxiliary materials into the extract powder obtained in the step b according to the weight ratio of 1:2, fully and uniformly mixing, taking 65% ethanol as an adhesive, adding ethanol, wherein the ethanol is 20% -50% of the extract powder, uniformly mixing, sieving by a 10-mesh sieve, drying at the temperature of 60 ℃, and preparing the traditional Chinese medicine compound preparation of granules, capsules, tablets or pills.

3. The use of the compound traditional Chinese medicine preparation according to claim 1 in the preparation of health food for preventing alcoholic liver injury.

Technical Field

The invention belongs to the technical field of traditional Chinese medicine compound preparations, and particularly relates to a traditional Chinese medicine compound preparation for preventing and treating alcoholic liver injury, and a preparation method and application thereof.

Background

With the rapid growth of economy and the increasing development of society in China, the living standard of people is greatly improved, the living style and the dietary structure are changed, high calorie and high fat are greatly ingested, and alcohol is greatly consumed, so that fatty liver disease is becoming the main cause of liver disease in China. Fatty liver disease is classified into nonalcoholic liver disease (NALD) and Alcoholic Liver Disease (ALD) according to different etiologies. Nonalcoholic liver disease is largely related to unhealthy lifestyle and unhealthy diet, and cardiovascular disease is the leading cause of death of nonalcoholic fatty liver disease. Alcoholic Liver Disease (ALD) is a number of liver diseases mainly due to long-term excessive alcohol consumption, with no clinical manifestations in the early stages, ranging from simple steatosis to steatohepatitis, liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC). In people who drink a lot of alcohol for a long time, the alcoholic fatty liver is about 90% -100%, the alcoholic hepatitis is about 10% -35%, and the alcoholic cirrhosis is finally developed to be 8% -20%. In 1990, 373,200 people died from alcoholic cirrhosis worldwide; in 2010, 493,300 deaths were due to alcoholic cirrhosis, accounting for 47.9% of all cirrhosis deaths, 337,400 deaths were due to liver cancer, accounting for 4.2% of cancer deaths. The rate of fatality of alcoholic liver disease has increased tremendously over the past two decades, constituting a serious health hazard to humans. Worldwide, alcoholic liver disease is one of the leading causes of liver disease.

The development and development of drugs for preventing and treating alcoholic liver diseases are imminent, and many effective components in traditional Chinese medicines such as flavonoids, polysaccharides, glycosides and the like can play a role in protecting the liver. Compared with western medicines, the traditional Chinese medicine has the advantages of small toxic and side effects and low drug dependence. The Chinese medicine can be used for preventing and treating alcoholic liver injury by multiple mechanisms, such as inhibiting oxygen free radicals, improving antioxidant protease bioactivity, protecting liver function, improving ethanol metabolism, etc.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine compound preparation for preventing and treating alcoholic liver injury and a preparation method and application thereof, the preparation is prepared by crushing and mixing the components of artemisia rupestris, oriental wormwood, cichorium intybus, rose, rhubarb and liquorice, and the auxiliary materials are lactose, dextrin, starch, sucrose or microcrystalline fiber, adding water for reflux extraction, filtering, concentrating to obtain an extract with the relative density of 1.1, performing vacuum drying to obtain a dry extract, crushing to obtain extract powder, adding the auxiliary materials, and preparing granules, capsules, tablets or pills according to a conventional method. The preparation has the advantages of convenient administration and good therapeutic effect. The animal model test shows that: the Chinese herbal medicine compound preparation can play a significant role in protecting the liver in the prevention and treatment of alcoholic liver injury diseases. Can obviously reduce the level of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase which are indexes of clear liver injury, and has obvious prevention and protection effects on alcoholic liver injury.

The invention relates to a Chinese medicinal compound preparation for preventing and treating alcoholic liver injury, which is prepared from (by weight ratio) 1000g of radix astragali, 5-60 parts of herba Achillea Wilsonianae, 5-50 parts of herba Artemisiae Scopariae, 5-50 parts of Cichorium hirsutum, 5-50 parts of flos Rosae Rugosae, 5-30 parts of radix et rhizoma Rhei, 5-30 parts of Glycyrrhrizae radix, and 4-60 parts of lactose, dextrin, starch, sucrose or microcrystalline fiber as adjuvant by conventional method into granule, capsule, tablet or pill.

The preparation method of the traditional Chinese medicine compound preparation for preventing and treating alcoholic liver injury comprises the following steps:

a. taking 1000g as a base number, 5-60 parts of artemisia rupestris, 5-50 parts of oriental wormwood, 5-50 parts of cichorium hirsutum, 5-50 parts of rose, 5-30 parts of rheum officinale and 5-30 parts of liquorice in parts by weight, respectively crushing into coarse powder of 20-40 meshes, mixing, adding water with the volume being 15-18 times of that of the raw material medicines, carrying out reflux extraction for 2-3 times, 2-3 hours each time, combining extracting solutions, filtering, and concentrating the filtrate at 60 ℃ under reduced pressure until the relative density is 1.1 to obtain an extract;

b. vacuum drying the extract obtained in the step a to obtain dry extract, and then crushing the dry extract and sieving the crushed dry extract with a 80-mesh sieve to obtain extract powder;

c. and (b) adding 4-60 parts of lactose, dextrin, starch, sucrose or microcrystalline cellulose serving as auxiliary materials into the extract powder obtained in the step b according to the weight ratio of 1:2, fully and uniformly mixing, taking 65% ethanol as an adhesive, adding ethanol, wherein the ethanol is 20% -50% of the extract powder, uniformly mixing, sieving by a 10-mesh sieve, drying at the temperature of 60 ℃, and preparing the traditional Chinese medicine compound preparation of granules, capsules, tablets or pills.

The application of the traditional Chinese medicine compound preparation in preparing health-care food for preventing alcoholic liver injury.

The invention relates to a Chinese medicinal compound preparation for preventing and treating alcoholic liver injury, a preparation method and application thereof, wherein the Chinese medicinal compound preparation has the advantages that: the traditional water extraction process is adopted to extract the traditional Chinese medicine compound preparation which takes total flavonoids, phenolic acid and the like as main effective components, and animal model tests show that: the Chinese herbal medicine compound preparation can play a significant role in protecting the liver in the prevention and treatment of alcoholic liver injury.

Drawings

FIG. 1 is a graph showing the effect of the present invention on biochemical indicators of mouse serum;

FIGS. 2-4 illustrate the effect of the present invention on liver function;

FIG. 5 is a graph showing the effect of the present invention on liver lipid levels.

The specific implementation mode is as follows:

the present invention is further illustrated by the following examples.