阅读说明：本技术 一种制附子的炮制工艺 (Processing technology of radix aconiti lateralis preparata ) 是由 黄勤挽 王瑾 王琳 于 2020-08-24 设计创作，主要内容包括：本发明提供了一种制附子的炮制工艺。该炮制工艺包括以下步骤：(1)取姜,加水煎煮,得姜汁；(2)在生附片中加入步骤(1)所得姜汁,闷润6～12小时,蒸制1～3小时,干燥后即得制附子炮制品。在本发明特定的炮制工艺下,配合特定的炮制参数(特别是姜与生附片的用量比例、闷润时间和蒸制时间),得到了毒性显著降低,且活性成分含量显著提高的制附子炮制品。本发明的炮制工艺简单、耗时较短、适合扩大生产,具有广阔的应用前景。(The invention provides a processing technology of radix aconiti lateralis preparata. The processing technology comprises the following steps: (1) decocting rhizoma Zingiberis recens with water to obtain rhizoma Zingiberis recens juice; (2) and (3) adding the ginger juice obtained in the step (1) into the raw radix aconiti lateralis preparata slices, moistening for 6-12 hours, steaming for 1-3 hours, and drying to obtain the processed radix aconiti lateralis preparata product. Under the specific processing technology of the invention, the processed monkshood product with obviously reduced toxicity and obviously improved active ingredient content is obtained by matching with specific processing parameters (especially the dosage proportion of the ginger and the raw monkshood, the moistening time and the steaming time). The processing method is simple in processing process, short in time consumption, suitable for expanded production and wide in application prospect.)

1. A processing technology of radix aconiti lateralis preparata is characterized in that: the processing technology comprises the following steps:

(1) decocting rhizoma Zingiberis recens with water to obtain rhizoma Zingiberis recens juice;

(2) and (3) adding the ginger juice obtained in the step (1) into the raw radix aconiti lateralis preparata slices, moistening for 6-12 hours, steaming for 1-3 hours, and drying to obtain the processed radix aconiti lateralis preparata product.

2. The processing process of claim 1, wherein: the weight of the ginger in the step (1) is 24-36% of that of the raw sliced aconite in the step (2).

3. The processing process of claim 2, wherein: in the step (2), the stuffy moistening temperature is 20-30 ℃, preferably 25-30 ℃, and more preferably 23 ℃.

4. The processing process of claim 3, wherein: in the step (2), the steaming temperature is 105-120 ℃, preferably 110-115 ℃, and more preferably 113 ℃.

5. The processing process according to any one of claims 1 to 4, wherein: the weight of the ginger in the step (1) is 36 percent of that of the raw sliced aconite in the step (2), the moistening time in the step (2) is 9 hours, and the steaming time is 3 hours;

or, the weight of the ginger in the step (1) is 30% of that of the raw sliced aconite in the step (2), the smoldering time in the step (2) is 12 hours, and the steaming time is 1 hour;

or, the weight of the ginger in the step (1) is 30% of that of the raw sliced aconite in the step (2), the smoldering time in the step (2) is 12 hours, and the steaming time is 3 hours;

or, the weight of the ginger in the step (1) is 24 percent of that of the raw sliced aconite in the step (2), the smoldering time in the step (2) is 6 hours, and the steaming time is 2 hours;

or, the weight of the ginger in the step (1) is 33 percent of that of the raw sliced aconite in the step (2), the moistening time in the step (2) is 9 hours, and the steaming time is 1.7 hours.

6. The processing process according to any one of claims 1 to 5, wherein: in the step (1), the ginger is dried ginger, preferably dried ginger decoction pieces.

7. The processing process according to any one of claims 1 to 5, wherein: in the step (1), the number of times of decoction is 1-3, preferably 2; the time for decoction is 0.5-2 hours each time, and preferably 1 hour each time.

8. The processing process according to any one of claims 1 to 5, wherein: in the step (1), the weight ratio of the ginger to the water is 1: (5-20), preferably 1: 12.

9. the processing process according to any one of claims 1 to 5, wherein: in the step (1), the ginger juice is concentrated ginger juice, and the concentration of the concentrated ginger juice is 0.10-0.50 g/mL, preferably 0.33g/mL calculated by the raw material ginger.

10. A processed product of radix Aconiti lateralis Preparata obtained by the processing method of any one of claims 1-9.

Technical Field

The invention belongs to the field of processing of traditional Chinese medicine decoction pieces, and particularly relates to a processing technology of radix aconiti lateralis preparata.

Background

Radix Aconiti lateralis is the lateral root (son root) of Aconitum carmichaeli Debx (Aconitum carmichaeli Debx.) belonging to Ranunculaceae, and is known as the first herb of restoring yang from collapse since Shen nong Ben Cao Jing (Shen nong Ben Cao Jing), and has excellent clinical efficacy. The aconite root is pungent, sweet and hot; is toxic. It enters heart, kidney and spleen meridians. It has effects of restoring yang, rescuing from collapse, invigorating fire, tonifying yang, and expelling pathogenic wind, cold and dampness. Can be used for treating yang exhaustion, collapse, cold limbs, slight pulse, sexual impotence, cold womb, psychroalgia of heart and abdomen, vomiting and diarrhea due to deficiency cold, edema due to yin cold, and arthralgia due to cold-dampness. However, ". The prepared aconite is extremely quick and rigid, the monkshood is toxic in doctors and herbal works all over the past, serious toxic and side effects are easy to occur due to improper use of the monkshood, the clinical manifestations of the monkshood are obvious cardiotoxicity and neurotoxicity, and certain toxicity is also generated in embryo and kidney, so the monkshood is suitable to be prepared into medicine clinically.

Regarding the processing technology of monkshood, as early as the song dynasty, the ginger is recorded as an auxiliary material, and the method for processing monkshood by using the ginger is firstly proposed in the 'Boji prescription': peeling, cutting into four pieces, decocting radix Aconiti lateralis Preparata with half rhizoma Zingiberis recens diligent and water in a bowl until the juice is full, and drying radix Aconiti lateralis Preparata to obtain powder. The Ming Dynasty "Ben Cao Zheng" also mentions: however, the original ginger juice is usually pungent and pungent, so it is not mild, and if the fruit is directly in the middle of the body and cold in the shade, the heat should be used well, but if it is used frequently, the property should be supplemented, so this means that the original purpose of processing monkshood with ginger is to "heat and heat" and to enhance the effect of tonifying fire and strengthening yang of monkshood by means of the pungent and hot property of ginger.

Diester alkaloids (such as aconitine, hypaconitine, and mesaconine) are the main components causing aconite poisoning, but are also the main active substances for strengthening heart, resisting inflammation and relieving pain. Such components are unstable in nature and C is present during moist heat₈The acetyl on the site is easy to hydrolyze to obtain corresponding benzoyl monoester alkaloid, such as benzoylaconitine, benzoylmesaconine, benzoylhypaconitine, etc., and the toxicity is gradually reduced, but the pharmacological action is also gradually weakened. The method can also be used for promoting diester-type alkaloid waterRelieving toxicity, and is prepared by decocting rhizoma Zingiberis recens, decocting rhizoma Zingiberis, squeezing rhizoma Zingiberis to obtain juice, mixing rhizoma Zingiberis recens with other materials, and steaming.

Chinese patent application CN107007662A discloses three processing methods of traditional Chinese medicine monkshood, which respectively obtain three processed monkshood products: roasted aconite, yin-fu and yang-fu. The processed product of the monkshood obtained by the processing method has much lower toxicity than the unprocessed product, and particularly the processed product of the monkshood is prepared by the following processing method: taking 100g of medicinal materials, washing and bleaching while simmering the aconite, taking out, drying, placing in a container, adding 15g of ginger juice, stirring uniformly, moistening for 12h, and taking out; putting into a wooden steamer, boiling water in the steamer, standing the steamer in a water-proof way, continuously steaming for 8 hours at 110 ℃, and taking out; spreading to dry, cutting into 3mm slices, and air drying. The radix Aconiti lateralis Preparata yin radix Aconiti lateralis Preparata tablet contains total alkaloids 56.25%, ester alkali 12.89%, and aconitine 20.35%. However, the processing method is time-consuming and tedious in steps, and the toxicity of the obtained processed product is still to be further reduced.

Therefore, a processing technology which has the advantages of short time consumption, simple and convenient operation, stability and controllability of each step, higher efficacy and lower toxicity of the prepared aconite product is needed to be researched.

Disclosure of Invention

The invention aims to provide a monkshood processing technology which has shorter time consumption and simpler and more convenient operation, so that the processed monkshood product has higher efficacy and lower toxicity.

The invention provides a processing technology of radix aconiti lateralis preparata, which comprises the following steps:

(1) decocting rhizoma Zingiberis recens with water to obtain rhizoma Zingiberis recens juice;

(2) and (3) adding the ginger juice obtained in the step (1) into the raw radix aconiti lateralis preparata slices, moistening for 6-12 hours, steaming for 1-3 hours, and drying to obtain the processed radix aconiti lateralis preparata product.

Further, the weight of the ginger in the step (1) is 24-36% of that of the raw sliced aconite in the step (2).

Further, in the step (2), the moistening temperature is 20-30 ℃, preferably 25-30 ℃, and more preferably 23 ℃.

Further, in the step (2), the steaming temperature is 105-120 ℃, preferably 110-115 ℃, and more preferably 113 ℃.

Further, the weight of the ginger in the step (1) is 36% of that of the raw sliced aconite in the step (2), the moistening time in the step (2) is 9 hours, and the steaming time is 3 hours;

or, the weight of the ginger in the step (1) is 30% of that of the raw sliced aconite in the step (2), the smoldering time in the step (2) is 12 hours, and the steaming time is 1 hour;

or, the weight of the ginger in the step (1) is 30% of that of the raw sliced aconite in the step (2), the smoldering time in the step (2) is 12 hours, and the steaming time is 3 hours;

or, the weight of the ginger in the step (1) is 24 percent of that of the raw sliced aconite in the step (2), the smoldering time in the step (2) is 6 hours, and the steaming time is 2 hours;

or, the weight of the ginger in the step (1) is 33 percent of that of the raw sliced aconite in the step (2), the moistening time in the step (2) is 9 hours, and the steaming time is 1.7 hours.

Further, in the step (1), the ginger is dried ginger, preferably dried ginger decoction pieces.

Further, in the step (1), the number of times of decoction is 1-3, preferably 2; the time for decoction is 0.5-2 hours each time, and preferably 1 hour each time.

Further, in the step (1), the weight ratio of the ginger to the water is 1: (5-20), preferably 1: 12.

further, in the step (1), the ginger juice is concentrated ginger juice, and the concentration of the concentrated ginger juice is 0.10-0.50 g/mL, preferably 0.33g/mL calculated by the raw material ginger.

The invention also provides a processed monkshood product prepared by the processing technology.

Experimental results show that the processed monkshood product with obviously reduced toxicity and obviously improved active ingredient content is obtained by matching specific processing parameters (particularly the dosage proportion of the ginger to the raw monkshood, the moistening time and the steaming time) under the specific processing method of the invention. The processing method is simple in processing process, short in time consumption, suitable for expanded production and wide in application prospect.

Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.

The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.

Detailed Description

The raw materials and equipment used in the invention are known products and are obtained by purchasing commercial products.

Wherein decoction pieces of Zingiberis rhizoma (dried rhizome of Zingiber officinale Rosc. of Zingiberaceae) are obtained from Sichuan flos Nelumbinis decoction pieces of Chinese medicinal materials Gmbycis, Inc., under the batch number of 1901037. The raw radix Aconiti lateralis is purchased from the radix Aconiti lateralis Preparata growing area of Sichuan Jiangyou. Aconitine, hypaconitine, mesaconine, benzoylmesaconine, benzoylaconine, and benzoylhypaconine references were all obtained from Kyopffer Biotech GmbH (lot numbers: 17022702, 17031401, 17011302, 150622, 141109, 17060104), and 6-gingerol reference was obtained from Kyofmann Biotech GmbH, lot number MUST-190210. Other reagents were analytically pure.