阅读说明：本技术 抗菌载药纱布的制备方法及糖尿病足患者用足套 (Preparation method of antibacterial drug-loaded gauze and foot cover for diabetic foot patient ) 是由 金立波 孙达 嵇豪 于 2020-07-06 设计创作，主要内容包括：本发明公开了一种抗菌载药纱布的制备方法及采用该纱布的糖尿病足患者用足套,涉及纱布制备领域,包括：(1)聚乙烯进行一段聚合反应；(2)在一段聚合产物中加入双键改性熊果酸,进行二段聚合；(3)挤出造粒制备改性聚乙烯母粒；(4)皮芯结构聚乙烯纤维制备；(5)改性聚乙烯纱布制备；(6)得到抗菌载药纱布制备；本发明制备得到的抗菌载药纱布具有长效抗菌性能,在使用过程中不会出现溶出的问题,抗菌作用长效持久,同时熊果酸作为天然物质,应用于人体时安全无副作用。(The invention discloses a preparation method of antibacterial drug-loaded gauze and a foot cover for a diabetic foot patient by adopting the gauze, relating to the field of gauze preparation and comprising the following steps: (1) carrying out first-stage polymerization reaction on polyethylene; (2) adding double bond modified ursolic acid into the first-stage polymerization product to carry out second-stage polymerization; (3) extruding and granulating to prepare modified polyethylene master batch; (4) preparing polyethylene fibers with a skin-core structure; (5) preparing modified polyethylene gauze; (6) preparing antibacterial drug-loaded gauze; the antibacterial drug-loaded gauze prepared by the invention has long-acting antibacterial performance, can not dissolve out in the using process, has long-acting antibacterial effect, and is safe and free of side effect when being applied to a human body as ursolic acid is used as a natural substance.)

1. The preparation method of the antibacterial drug-loaded gauze is characterized by comprising the following preparation steps:

(1) placing raw materials of ethylene gas, comonomer alpha-olefin, hydrogen, catalyst and isobutane in a reaction kettle to carry out a first-stage polymerization reaction;

(2) adding double bond modified ursolic acid into the first-stage polymerization product, carrying out second-stage polymerization, and separating and drying to obtain polymer powder;

(3) extruding and granulating polymer powder to prepare modified polyethylene master batch;

(4) heating and melting the modified polyethylene master batch to obtain a spinning solution A; melting the conventional polyethylene master batch to obtain spinning solution B;

(5) spinning by using the spinning solution A as a skin layer and the spinning solution B as a core layer through a skin-core spinning assembly, and then extracting, drying and carrying out hot drawing to prepare the skin-core structure polyethylene fiber;

(6) dispersing polyethylene fibers with a skin-core structure in water, carding, lapping, drawing, performing two-stage spunlace, drying at high temperature, sterilizing, slitting and rolling to obtain modified polyethylene gauze;

(7) and soaking the modified polyethylene gauze into the medicinal solution, and vibrating and adsorbing under vacuum to prepare the antibacterial medicine-carrying gauze.

2. The method for preparing antibacterial drug-loaded gauze according to claim 1, wherein the α -olefin in step (1) comprises one or more of propylene, 1-butene or 1-hexene, and the α -olefin is used in an amount of 0.5 to 1 mol% of the total polymerization yield.

3. The method for preparing antibacterial drug-loaded gauze according to claim 1, wherein the molar ratio of the ethylene gas to the hydrogen gas in the step (1) is 1: 2.5-3.

4. The preparation method of antibacterial drug-loaded gauze according to claim 1, wherein the amount of the double-bond modified ursolic acid added in step (2) is 0.1-0.5 wt% of ethylene gas, and the preparation method comprises: placing ursolic acid in ethanol solution to prepare mixed solution, then adding stannic chloride, dropwise adding allyl alcohol glycidyl ether at 65-75 ℃, continuously stirring for reaction, and then carrying out reduced pressure distillation to prepare the double-bond modified ursolic acid.

5. The method for preparing antibacterial drug-loaded gauze according to claim 1, wherein the first-stage polymerization reaction in the step (1) is polymerization at 80-90 ℃ and 1-2MPa for 1-2 h; the two-stage polymerization reaction in the step (2) is polymerization for 1.5-2h at the temperature of 80-90 ℃ and the pressure of 1-1.5 MPa.

6. The preparation method of the antibacterial and drug-loaded gauze according to claim 1, wherein the mass ratio of the spinning solution A to the spinning solution B in the step (5) is 1-2: 5.

7. The method for preparing antibacterial drug-loaded gauze according to claim 1, wherein the length of the skin-core structure polyethylene fiber in the step (5) is 10-15 mm; the fineness is 0.8-1.5 dtex.

8. The method for preparing antibacterial drug-loaded gauze according to claim 1, wherein in the two-stage water stabbing in the step (6), the pressure at one stage is 50-100bar, and the pressure at one stage is 100-150 bar.

9. The method for preparing antibacterial drug-loaded gauze according to claim 1, wherein the drugs in step (7) are diclofenac potassium and mupirocin.

10. A diabetic foot cover obtained from gauze by the method of any one of claims 1 to 9.

Technical Field

The invention relates to the field of gauze preparation, in particular to a preparation method of antibacterial drug-loaded gauze and a foot cover for a diabetic foot patient by adopting the gauze.

Background

Diabetes is a metabolic disease characterized by hyperglycemia due to defective insulin secretion or impaired insulin action; persistent hyperglycemia and long-term metabolic disorders, etc., can lead to damage to tissues and organs throughout the body, particularly the eye, kidney, cardiovascular system and nervous system, as well as dysfunction and failure thereof; serious patients can cause acute complications of ketoacidosis and hyperosmolar coma, such as dehydration, electrolyte disturbance and acid-base balance disturbance. There are many causes for diabetic feet, and there are studies that improper footwear causes more than one third of diabetic feet to be ulcerated, while 85% of diabetic feet are amputated due to the foot ulcers. With the increasing incidence of diabetes and the aging of population, the incidence of diabetic feet is increasing, the wound surface of the foot of a diabetic patient is not healed, the liquid seeps more even if debridement and dressing change are carried out, and the clothes and quilts are easily polluted.

For example, a method for preparing medical antibacterial cotton gauze disclosed in chinese patent literature, whose publication number is CN105671942A, discloses a method for preparing medical antibacterial cotton gauze, comprising the following steps: carrying out puffing pretreatment on cotton gauze; performing carboxymethylation modification treatment on the pretreated cotton gauze; washing with water: washing with water for several times; and (3) antibacterial treatment: putting the washed cotton gauze into water with a bath ratio of 1:25, adding a compound antibacterial agent accounting for 5-8% of the weight of the cotton gauze, raising the temperature to about 40-48 ℃, and treating for 2.5-3 h, wherein the compound antibacterial agent comprises nano titanium dioxide, modified chitosan, artemisia oil and a tea extract; water squeezing: squeezing the cotton gauze subjected to the antibacterial treatment to enable the water content of the cotton gauze to be 10-20% of the weight of the cotton gauze; drying: and putting the cotton gauze after being squeezed into a vacuum drying box for drying. Although the invention endows the cotton gauze with antibacterial performance, the antibacterial agent is easy to separate out in the storage and use process, and the later use function is influenced.

Disclosure of Invention

The invention provides a preparation method of antibacterial drug-loaded gauze and a foot cover for a diabetic foot patient by using the antibacterial drug-loaded gauze, aiming at overcoming the problems that the antibacterial agent is easily separated out in the storage and use process of the antibacterial gauze soaked with the antibacterial agent, the later use function is influenced and the like in the prior art.

In order to achieve the purpose, the invention adopts the following technical scheme:

a preparation method of antibacterial drug-loaded gauze comprises the following preparation steps:

(1) placing raw materials of ethylene gas, comonomer alpha-olefin, hydrogen, catalyst and isobutane in a reaction kettle to carry out a first-stage polymerization reaction;

(2) adding double bond modified ursolic acid into the first-stage polymerization product, carrying out second-stage polymerization, and separating and drying to obtain polymer powder;

(3) extruding and granulating polymer powder to prepare modified polyethylene master batch;

(4) heating and melting the modified polyethylene master batch to obtain a spinning solution A; melting the conventional polyethylene master batch to obtain spinning solution B;

(5) spinning by using the spinning solution A as a skin layer and the spinning solution B as a core layer through a skin-core spinning assembly, and then extracting, drying and carrying out hot drawing to prepare the skin-core structure polyethylene fiber;

(6) dispersing polyethylene fibers with a skin-core structure in water, carding, lapping, drawing, performing two-stage spunlace, drying at high temperature, sterilizing, slitting and rolling to obtain modified polyethylene gauze;

(7) and soaking the modified polyethylene gauze into the medicinal solution, and vibrating and adsorbing under vacuum to prepare the antibacterial medicine-carrying gauze.

In the preparation process of the gauze, polyethylene fibers are used as raw materials to prepare the gauze, modified polyethylene is obtained in a two-stage series polymerization mode, firstly, polyethylene with a certain molecular weight is prepared in a one-stage polymerization mode, then, double-bond modified ursolic acid is added to continue to carry out two-stage polymerization, and the double-bond modified ursolic acid is directly polymerized and grafted into the polyethylene to form a small block in a polyethylene molecular chain. The ursolic acid is used as natural organic acid with antibacterial effect, and after the ursolic acid is subjected to block polymerization with polyethylene, the modified polyethylene is endowed with excellent antibacterial performance, and because the ursolic acid exists in a small block form in a polyethylene molecular chain, the ursolic acid cannot be dissolved out in the using process, the antibacterial effect is long-acting and lasting, and meanwhile, the ursolic acid is used as a natural substance, and is safe and free of side effects when being applied to a human body. In addition, the invention adopts a two-stage polymerization mode during polymerization, firstly polyethylene with a certain molecular weight is prepared, and then double-bond modified ursolic acid is added for polymerization, so that the molecular structure of the modified polyethylene can be effectively controlled, and the performance of the polyethylene is not influenced. And then, when the fiber is prepared, the modified polyethylene is used as a skin layer, the conventional polyethylene is used as a core layer, and the polyethylene fiber with the skin-core structure is prepared, because the spinnability of the modified polyethylene is inevitably poorer than that of the conventional polyethylene, the polyethylene fiber with the skin-core structure is prepared, the problem of the performance of the polyethylene fiber caused by the poor spinnability of the modified polyethylene can be avoided, the modified polyethylene positioned on the skin layer can exert the good antibacterial effect, and the cost is reduced. And finally, soaking the prepared gauze in a medicinal solution to prepare the antibacterial medicine-carrying gauze.

Preferably, the alpha-olefin in step (1) comprises one or more of propylene, 1-butene or 1-hexene, and the alpha-olefin is used in an amount of 0.5 to 1 mol% based on the total production of the polymerization.

Preferably, the molar ratio of the ethylene gas to the hydrogen gas in the step (1) is 1: 2.5-3.

Preferably, the double bond modified ursolic acid is added in the step (2) in an amount of 0.1 to 0.5 wt% of the ethylene gas, and the preparation method comprises the following steps: placing ursolic acid in ethanol solution to prepare mixed solution, then adding stannic chloride, dropwise adding allyl alcohol glycidyl ether at 65-75 ℃, continuously stirring for reaction, and then carrying out reduced pressure distillation to prepare the double-bond modified ursolic acid.

In the invention, the double bond modification of ursolic acid is carried out by adopting allyl alcohol glycidyl ether, because the epoxy group on the allyl alcohol glycidyl ether can carry out ring-opening reaction with the hydroxyl on the ursolic acid under the action of the catalyst, the double bond is successfully grafted on the ursolic acid, and the double bond modification of the ursolic acid is completed.

Preferably, the first-stage polymerization reaction in the step (1) is polymerization for 1-2h at the temperature of 80-90 ℃ and the pressure of 1-2 MPa; the two-stage polymerization reaction in the step (2) is polymerization for 1.5-2h at the temperature of 80-90 ℃ and the pressure of 1-1.5 MPa.

Preferably, the mass ratio of the spinning solution A to the spinning solution B in the step (5) is 1-2: 5.

Preferably, the length of the polyethylene fiber with the sheath-core structure in the step (5) is 10-15 mm; the fineness is 0.8-1.5 dtex.

Preferably, in the two-stage water stabbing in the step (6), the pressure of the first stage is 50-100bar, and the pressure of the first stage is 100-150 bar.

Preferably, the drug in step (7) is diclofenac potassium or mupirocin.

A foot cover for diabetic foot patient with antibacterial drug-loaded gauze is provided.

Therefore, the invention has the following beneficial effects: the antibacterial drug-loaded gauze prepared by the invention has long-acting antibacterial performance, can not dissolve out in the using process, has long-acting antibacterial effect, and is safe and free of side effect when being applied to a human body as ursolic acid is used as a natural substance.

Detailed Description

The invention is further described with reference to specific embodiments.