阅读说明：本技术 低皮肤刺激作用的氯氟氰菊酯悬浮杀虫剂及制备方法 (Cyhalothrin suspension insecticide with low skin irritation and preparation method thereof ) 是由 彭昆 姜海鹏 陈新星 刘志勇 于 2020-08-03 设计创作，主要内容包括：本发明公开一种低皮肤刺激作用的氯氟氰菊酯悬浮杀虫剂及制备方法包括：氯氟氰菊酯原药；润湿剂；分散剂；增稠剂；消泡剂；防冻剂；防腐剂；调节剂；余量为水；其中润湿剂和分散剂根据本配方特点自行研制,并公开了其制备方法；此外本发明还公开了上述具有低皮肤刺激作用的氯氟氰菊酯悬浮杀虫剂的制备方法。本发明提供的悬浮药剂的优点是可与水任意比例均匀混合分散,流动性好,具有调节作物活性、提高药效、不受水质、水温影响,使用方便,不易污染环境,可稀释后喷雾。通过各组分的配比调节,使得该悬浮剂不仅具有良好杀菌效果且可适当调节植物生长,大大减少了对农作物和人体的伤害。(The invention discloses a cyhalothrin suspension insecticide with low skin irritation and a preparation method thereof, wherein the preparation method comprises the following steps: cyhalothrin raw pesticide; a wetting agent; a dispersant; a thickener; defoaming agents; an anti-freezing agent; a preservative; a modulator; the balance of water; wherein, the wetting agent and the dispersant are developed according to the characteristics of the formula, and the preparation method thereof is disclosed; in addition, the invention also discloses a preparation method of the cyhalothrin suspension insecticide with low skin irritation. The suspending agent provided by the invention has the advantages of being capable of being uniformly mixed and dispersed with water in any proportion, good in fluidity, capable of adjusting the activity of crops and improving the drug effect, free from the influence of water quality and water temperature, convenient to use, not easy to pollute the environment, and capable of spraying after being diluted. Through the proportion adjustment of the components, the suspending agent has good sterilization effect, can properly adjust the growth of plants, and greatly reduces the damage to crops and human bodies.)

1. Cyhalothrin suspension insecticide with low skin irritation effect is characterized by comprising the following components:

the components are calculated according to parts by weight.

2. The low skin irritation cyhalothrin suspension insecticide of claim 1, wherein: the preparation method of the dispersant comprises the following steps:

(11) weighing a certain proportion of alkylphenol polyoxyethylene ether phosphate and polyoxyethylene sorbitan fatty acid ester, placing the alkylphenol polyoxyethylene ether phosphate and the polyoxyethylene sorbitan fatty acid ester into a reactor, adjusting the temperature to 0-20 ℃, and carrying out high-speed shearing and mixing under the condition that the rotating speed is 1500-3000 r/min; stirring for 1-2 h;

(12) adding a polyoxyethylene polyoxypropylene ether segmented copolymer into the system obtained in the step (11), adjusting the temperature to 15-25 ℃, and continuing high-speed shearing and mixing under the condition that the rotating speed is 2000-2500 r/min; stirring for 1-2 h;

(13) and (3) adding a polar solvent, a non-polar solvent or an environment-friendly solvent into the system obtained in the step (12) in a certain proportion, mixing at the rotating speed of 1000-2000 r/min, and stirring for 0.5-1 h to obtain the dispersing agent.

3. The low skin irritation cyhalothrin suspension insecticide of claim 2, wherein: in the dispersing agent, the mass ratio of alkylphenol polyoxyethylene phosphate, polyoxyethylene sorbitan fatty acid ester and polyoxyethylene polyoxypropylene block copolymer is 1: 0.5-1.5: 1-2.

4. The cyhalothrin suspension insecticide with low skin irritation as claimed in claim 1, wherein: the wetting agent is selected from at least two of triphenylethylene phenol polyoxyethylene ether phosphate sulfonate, triphenylethylene phenol polyoxyethylene ether phosphate triethanolamine salt, triphenylethylene phenol polyoxyethylene ether formaldehyde condensate sulfate, sodium lignosulfonate and calcium lignosulfonate.

5. The low skin irritation cyhalothrin suspension insecticide of claim 4, wherein: the wetting agent is triphenylethylene phenol polyoxyethylene ether phosphate sulfonate and calcium lignosulfonate according to a mass ratio of 1: 0.5-2.

6. The low skin irritation cyhalothrin suspension insecticide of claim 1, wherein: the thickening agent is selected from one or more of xanthan gum, magnesium aluminum silicate, Arabic gum, methyl cellulose, carboxymethyl cellulose, polyvinyl alcohol and fumed silica.

7. The low skin irritation cyhalothrin suspension insecticide of claim 1, wherein: the defoaming agent is selected from one or more of polydimethylsiloxane, polyether modified siloxane, polypropylene glycol and polyethylene glycol.

8. The low skin irritation cyhalothrin suspension insecticide of claim 1, wherein: the antifreeze is one or more selected from ethylene glycol, propylene glycol, glycerol monoethyl ether diglycol and urea.

9. The low skin irritation cyhalothrin suspension insecticide of claim 1, wherein: the preservative is selected from one or more of sodium benzoate, isothiazolinone, formaldehyde or paraformaldehyde;

the regulator is selected from compound sodium nitrophenolate, diethylaminoacetate caproate, sodium naphthylacetate, potassium indolebutyrate, gibberellin, triacontanol and brassinolide. One or more of forchlorfenuron.

10. A process for preparing a cyhalothrin suspension insecticide with low skin irritation as claimed in claim 1, characterized by comprising the steps of:

(21) weighing water, a regulator and an antifreezing agent according to a formula, and stirring and mixing at 38-43 ℃ to form a uniform mixed solution;

(22) adding a dispersing agent into the system in the step (21), adjusting the temperature to 42-45 ℃, slowly adding a one-third formula amount of cyhalothrin raw pesticide through a negative pressure system, and stirring while keeping the temperature until the mixture is uniformly mixed;

(23) adding a certain amount of wetting agent and defoaming agent into the system in the step (22), and shearing, dispersing and mixing by adopting a dispersing and shearing machine under the condition of 1500-3000 r/min;

(24) adding a certain amount of thickening agent and preservative into the system in the step (23), and continuously shearing, dispersing and mixing by adopting a dispersing and shearing machine under the condition of 2000-2500 r/min; slowly dripping a certain amount of defoaming agent in the stirring process;

(25) cooling the system to 0-5 ℃, preserving heat, and circularly wet-grinding the system by using a sand mill until the particle fineness is 1-5 mu m;

(26) adding one third of the amount of the cyhalothrin raw pesticide into the system in the step (25), and shearing, dispersing and mixing by adopting a dispersing shearing machine under the condition of 2000-2500 r/min; then, circularly wet-grinding the mixture by using a sand mill until the particle fineness is 1 to 5 mu m;

(27) adding the residual cyhalothrin raw pesticide with the amount of one third of the formula amount into the system in the step (26), and operating according to the method in the step (26), and crushing the material to the particle size of 1-5 mu m; the temperature in the whole sanding process needs to be controlled to be 0-5 ℃; and adding a certain amount of defoaming agent in the sanding process to perform defoaming treatment, obtaining the cyhalothrin suspension insecticide after sanding is finished, detecting the cyhalothrin suspension insecticide, and packaging after quality is qualified.

Technical Field

The invention belongs to the technical field of plant sterilization agents, and particularly relates to a cyhalothrin suspension insecticide which has a good sterilization effect, has little irritation to the skin of a user and can properly regulate the growth of plants, and a preparation method thereof.

Background

Cyhalothrin, chemical name: 1- (4-chlorophenoxy) -1- (1H-1,2, 4-triazole-1-yl) -3, 3-dimethyl-butan-2-ol, cyhalothrin is a low toxicity broad spectrum pesticide. The bactericidal composition is used for preventing and treating diseases such as rust disease, powdery mildew, sheath blight and the like of wheat, rice and has an obvious yield increasing effect. Can also be used as a cereal seed treating agent and for preventing and treating cereal head smut.

Cyhalothrin is mainly oriented to the market as wettable powder and missible oil in China. The wettable powder is easy to generate dust pollution during processing and use, and the suspension rate of the wettable powder is lower than that of a suspending agent, so that the product is easy to generate phytotoxicity; the production of the missible oil uses a large amount of organic solvent, which wastes resources and pollutes the environment after being used. Therefore, with the enhancement of the environmental awareness of people and the development requirement of modern agriculture, the significance of developing a safe and novel pesticide formulation is very important. In addition, the existing plant bactericidal drugs in the market have great harm to plants after being used, often cause the poor production of the plants, influence the quality and the yield of crops, have great toxicity, and have great harm to drug applicators, particularly skin injury. Therefore, it is required to develop a novel bactericide and a preparation method thereof, which can exert a good bactericidal effect on plants, reduce the growth damage to the plants, have a certain growth regulating effect, improve the growth quality of crops, and maximally reduce the skin irritation to a drug applicator.

Disclosure of Invention

The purpose of the invention is as follows: the invention aims to provide a cyhalothrin suspension insecticide which is environment-friendly, safe, low in cost, has a good sterilization effect, can properly regulate plant growth and reduce skin irritation, and aims to overcome the defects of environmental pollution, harm to human health, phytotoxicity, high use cost and the like in the prior art.

The invention also aims to provide the preparation method of the cyhalothrin suspension insecticide which is environment-friendly, safe, low in cost and capable of properly regulating the growth of plants.

The technical scheme is as follows: the cyhalothrin suspension insecticide with low skin irritation comprises the following components:

the components are calculated according to parts by weight.

Further, in order to improve the suspension dispersion effect of the medicament, the preparation method of the dispersing agent comprises the following steps:

(11) weighing a certain proportion of alkylphenol polyoxyethylene ether phosphate and polyoxyethylene sorbitan fatty acid ester, placing the alkylphenol polyoxyethylene ether phosphate and the polyoxyethylene sorbitan fatty acid ester into a reactor, adjusting the temperature to 0-20 ℃, and carrying out high-speed shearing and mixing under the condition that the rotating speed is 1500-3000 r/min; stirring for 1-2 h;

(12) adding a polyoxyethylene polyoxypropylene ether segmented copolymer into the system obtained in the step (11), adjusting the temperature to 15-25 ℃, and continuing high-speed shearing and mixing under the condition that the rotating speed is 2000-2500 r/min; stirring for 1-2 h;

(13) and (3) adding a polar solvent, a non-polar solvent or an environment-friendly solvent into the system obtained in the step (12) in a certain proportion, mixing at the rotating speed of 1000-2000 r/min, and stirring for 0.5-1 h to obtain the dispersing agent.

Further, as a preferred embodiment of suspension dispersion, the mass ratio of the alkylphenol polyoxyethylene ether phosphate, the polyoxyethylene sorbitan fatty acid ester and the polyoxyethylene polyoxypropylene ether block copolymer in the dispersant is 1: 0.5-1.5: 1-2.

Further, in order to improve the dispersion effect of the dispersant, the polar solvent is selected from one or more of ethanol, ethylene glycol, glycerol, dimethyl sulfoxide or N, N-dimethylformamide; the nonpolar solvent is selected from one or more of sec-butyl acetate, ethyl acetate, toluene and xylene; the environment-friendly solvent is selected from one or more of No. 120 solvent naphtha, No. 150 solvent naphtha and No. 200 solvent naphtha.

Further, the wetting agent is selected from at least two of triphenylethylene phenol polyoxyethylene ether phosphate sulfonate, triphenylethylene phenol polyoxyethylene ether phosphate triethanolamine salt, triphenylethylene phenol polyoxyethylene ether formaldehyde condensate sulfate, sodium lignosulfonate and calcium lignosulfonate.

Further, the wetting agent is triphenylethylene phenol polyoxyethylene ether phosphate sulfonate and calcium lignosulfonate according to a mass ratio of 1: 0.5-2.

Further, the thickening agent is selected from one or more of xanthan gum, magnesium aluminum silicate, Arabic gum, methylcellulose, carboxymethylcellulose, polyvinyl alcohol and fumed silica.

Further, the defoaming agent is selected from one or more of polydimethylsiloxane, polyether modified siloxane, polypropylene glycol and polyethylene glycol.

Further, the antifreezing agent is selected from one or more of ethylene glycol, propylene glycol, glycerol monoethyl ether and diethylene glycol, and urea.

Further, the preservative is selected from one or more of sodium benzoate, isothiazolinone, formaldehyde or paraformaldehyde;

the regulator is selected from one or more of p-nitrophenol sodium, caproic acid diethylamino acetate, o-nitrophenol sodium and brassinolide.

The invention also provides a preparation method of the cyhalothrin suspension insecticide, which comprises the following steps:

(21) weighing water, a regulator and an antifreezing agent according to a formula, and stirring and mixing at 38-43 ℃ to form a uniform mixed solution;

(22) adding a dispersing agent into the system in the step (21), adjusting the temperature to 42-45 ℃, slowly adding a one-third formula amount of cyhalothrin raw pesticide through a negative pressure system, and stirring while keeping the temperature until the mixture is uniformly mixed;

(23) adding a certain amount of wetting agent and defoaming agent into the system in the step (22), and shearing, dispersing and mixing by adopting a dispersing and shearing machine under the condition of 1500-3000 r/min;

(24) adding a certain amount of thickening agent and preservative into the system in the step (23), and continuously shearing, dispersing and mixing by adopting a dispersing and shearing machine under the condition of 2000-2500 r/min; slowly dripping a certain amount of defoaming agent in the stirring process;

(25) cooling the system to 0-5 ℃, preserving heat, and circularly wet-grinding the system by using a sand mill until the particle fineness is 1-5 mu m;

(26) adding one third of the amount of the cyhalothrin raw pesticide into the system in the step (25), and shearing, dispersing and mixing by adopting a dispersing shearing machine under the condition of 2000-2500 r/min; then, circularly wet-grinding the mixture by using a sand mill until the particle fineness is 1 to 5 mu m;

(27) adding the residual cyhalothrin raw pesticide with the amount of one third of the formula amount into the system in the step (26), and operating according to the method in the step (26), and crushing the material to the particle size of 1-5 mu m; the temperature in the whole sanding process needs to be controlled to be 0-5 ℃; and adding a certain amount of defoaming agent in the sanding process to perform defoaming treatment, obtaining the cyhalothrin suspension insecticide after sanding is finished, detecting the cyhalothrin suspension insecticide, and packaging after quality is qualified.

Has the advantages that: (1) the suspension medicament provided by the invention has the advantages of being capable of being uniformly mixed and dispersed with water in any proportion, good in fluidity, convenient to use, not easy to pollute the environment and capable of being diluted and sprayed, and has the effects of regulating the activity of crops and improving the pesticide effect, and is not influenced by water quality and water temperature; (2) the special dispersing agent is added, so that the suspension dispersing effect is greatly improved; (3) the suspending agent provided by the invention is processed by a wet method, does not generate dust, replaces an organic solvent with water, meets the requirement of environmental protection, has a finer product granularity than wettable powder, has uniform dispersion of effective ingredients, high suspension rate and higher drug effect than the wettable powder, is an ideal environment-friendly new formulation at present, and has small skin irritation to a drug applicator; (4) through the proportion adjustment of the components, the suspending agent has good sterilization effect, can properly adjust the growth of plants, and greatly reduces the damage to crops.

Drawings

FIG. 1 is a process flow diagram of an embodiment of the present invention.

Detailed Description

The technical solution of the present invention is described in detail by the following examples, but the scope of the present invention is not limited to the examples.