阅读说明：本技术 一种抗菌抗病毒纳米水性浆料的制备方法 (Preparation method of antibacterial and antiviral nano water-based slurry ) 是由 陈照峰 李曼娜 于 2020-06-19 设计创作，主要内容包括：本发明提供了一种抗菌抗病毒纳米材料水性浆料的制备方法,首先,用无机锌盐溶液滴加到氢氧化钠溶液,控制温度、pH值等,制备出柱状纳米ZnO粉体；其次用柱状纳米ZnO粉体、Cu<Sub>2</Sub>SO<Sub>4</Sub>水溶液,和一定量的NaOH、CTAB、GO水溶液和水合肼,超声混合反应,制备Cu<Sub>2</Sub>O-ZnO-GO纳米复合粉体,最后将Cu<Sub>2</Sub>O-ZnO-GO纳米复合粉体加入到混合分散液中,搅拌后得到抗菌抗病毒纳米水性浆料。本发明制备的浆料特点在于柱状纳米ZnO、Cu<Sub>2</Sub>O仿生了蜻蜓翅膀纳米突起结构,且利用GO较大的表面积将两者均匀负载,形成的纳米复合粉体可有效灭活大肠杆菌、金黄色葡萄球菌、肺炎链球菌等细菌和流感病毒、SARS等无包膜病毒,在涂层、涂料、植入体、家用电器等领域具有广泛应用前景。(The invention provides a preparation method of antibacterial and antiviral nano-material aqueous slurry, which comprises the steps of firstly, dropwise adding an inorganic zinc salt solution into a sodium hydroxide solution, and controlling the temperature, the pH value and the like to prepare columnar nano ZnO powder; secondly, columnar nano ZnO powder and Cu are used 2 SO 4 Ultrasonic mixing reaction of the aqueous solution, a certain amount of NaOH, CTAB and GO aqueous solution and hydrazine hydrate to prepare Cu 2 O-ZnO-GO nano composite powder, and finally adding Cu 2 O-ZnO-GO nano-meterAdding the composite powder into the mixed dispersion liquid, and stirring to obtain the antibacterial and antiviral nano aqueous slurry. The slurry prepared by the invention is characterized in that the columnar nano ZnO and Cu 2 O simulates a dragonfly wing nano-protrusion structure, and the GO is uniformly loaded on the surface of the dragonfly wing nano-protrusion structure by utilizing the larger surface area of the GO, so that the formed nano-composite powder can effectively inactivate bacteria such as escherichia coli, staphylococcus aureus, streptococcus pneumoniae and the like, influenza virus, SARS and other non-enveloped viruses, and has wide application prospect in the fields of coatings, implants, household appliances and the like.)

1. A preparation method of antibacterial and antiviral nano water-based slurry is characterized by comprising the following steps in sequence:

(1) preparing inorganic zinc salt and sodium hydroxide into aqueous solutions by using deionized water respectively, dropwise adding the inorganic zinc salt solution into the sodium hydroxide solution under the condition of magnetic stirring at the temperature of 60-90 ℃, controlling the pH value of the solution within the range of 11-13, and carrying out water bath heat preservation after dropwise adding; after the reaction is finished, the columnar nano ZnO powder is prepared after filtration, separation, drying and pyrolysis.

(2) Adding columnar nano ZnO powder into Cu₂SO₄Adding a certain amount of NaOH aqueous solution, CTAB aqueous solution, GO aqueous solution and hydrazine hydrate into the aqueous solution, carrying out ultrasonic mixing reaction, then washing, and carrying out vacuum drying at 60-90 ℃ to obtain Cu₂O-ZnO-GO nano composite powder;

(3) mixing 0.5-3 wt% of titanate YY-2 coupling agent, 0.5-5 wt% of disodium coconut monoethanolamide sulfosuccinate surfactant, 0.3-0.5 wt% of polyethylene glycol dispersant and 50-60 wt% of polyacrylic acid binder to prepare a mixed dispersion solution;

(4) mixing Cu₂Adding the O-ZnO-GO nano composite powder into the mixed dispersion solution, and stirring to obtain the antibacterial and antiviral nano aqueous slurry.

Technical Field

The invention relates to a method for preparing antibacterial and antiviral nano material aqueous slurry, in particular to a method for preparing columnar nano cuprous oxide, nano zinc material and two-dimensional planar graphene oxide nano composite powder aqueous slurry.

Technical Field

Antibacterial nano materials are always the object of research of domestic and foreign research institutions and scholars, and are divided into metal type, photocatalytic type, quaternary ammonium salt modified inorganic nano antibacterial materials and composite nano antibacterial materials. Ag in metal material⁺Because of its spectrum antibacterial property and non-toxicity to eukaryotic cells, it is widely used; the photocatalytic material is Ti₂O is a representative, which not only can influence the bacterial reproduction, but also can attack the outer layer of bacterial cells, penetrate cell membranes, completely degrade the bacteria and prevent the generation of endotoxin to cause secondary pollution; two other types of materials commonly used are Si₂Covalent grafting of macromolecular quaternary ammonium salt, Ag on O surface⁺The zeolite structure is modified. However, the antiviral studies of nanomaterials are rarely involved in the above, and the ebola virus in 1976, the SARS virus in 2003, MERS in 2012, and the novel coronavirus in 2019 appeared with irreparable consequences, and the species and latency and propagation pathway of the future virus are more unpredictable. At present, the number of people diagnosed with new coronary pneumonia is over 452 thousands, the number of death cases is over 30.3 thousands, and the number is continuously increasing. Based on international environmental requirements and the singleness and limitation of the research of most nano antibacterial materials, the design and development of novel antibacterial and antiviral materials with the functions of quickly and efficiently sterilizing and continuously and effectively inactivating viruses becomes an important direction of the current nano technology expansion research.

Chinese patent No. CN03133534.9 discloses a porous solid material for adsorbing and inactivating viruses and its application. Relates to a porous solid material for adsorbing and inactivating viruses and application thereof, wherein the component of the porous solid material is TiO₂、ZrO₂、SiO₂、Al₂O₃Or P₂O₅One or a combination of the two, the structure is characterized by having the property of multiple pores, the aperture is within the range of 0.3-500 nm, and the pore volume is 0.01-3 ml/g; one or more modifying elements in VIII group, Ib group, IIb group and IIa group in the periodic table of elements can be adopted to modify the virus-killing agent so as to achieve the aim of effectively inactivating virus molecules. Porous solid of the inventionThe material has nonspecific adsorption and inactivation effects on viruses, and particularly has adsorption and inactivation effects on coronavirus such as parainfluenza virus. Chinese patent with application number CN201911402063.9 discloses a bio-based antibacterial and antiviral nano-material, and a preparation method and application thereof, in the process of preparing the material, cellulose nanocrystals are used as a carrier, and metal ions are loaded on the cellulose nanocrystals to form a composite material through the adhesion effect of polydopamine, and the composite material not only has good biocompatibility, environmental protection and degradability, but also has excellent antibacterial and antiviral effects. The composite material is used for preventing and controlling agricultural diseases, and can provide a new strategy for reducing and improving the amount of pesticides and realizing green prevention and control of agricultural diseases. The preparation method of the composite material is simple and easy to operate, and is suitable for expanded production.

British patent application No. CN200680000645.9 discloses functional nanomaterials with antibacterial and antiviral activity, relating to nanomaterials comprising a metal oxide in combination with an antibacterial active cationic metal. In particular, the present invention relates to nanocrystalline compounds of formula (I): AO_x-(L-Men⁺)_i(I) wherein, AO_xRepresents a metal oxide or a nonmetal oxide, x ═ 1 or 2; men⁺Is a metal ion having antibacterial activity, n is 1 or 2; l is an organic or organometallic difunctional molecule capable of simultaneously binding a metal oxide or metalloid oxide and a metal ion Men⁺(ii) a i represents and AO_xNumber of L-Men + groups bound by the nanoparticle.

The three inventions solve the preparation problem of the antiviral nano material to a certain extent and the problem of applying the antiviral nano material in some fields. The application No. CN03133534.9 patent, the load of the nano porous material becomes a problem, the application No. CN201911402063.9 patent, the application range of the organic nano material is concentrated in agriculture, the problem of virus transmission is difficult to solve, the application No. CN200680000645.9 patent, the metal ion nano material is mainly applied to the antibacterial and antiviral skin medicine.

Viruses are much smaller than bacteria, typically in the tens to hundreds of nanometers range. The nano composite material is prepared into slurry for coating and dipping, so that the corresponding material or product can adsorb and inactivate viruses, and a very positive effect on prevention and treatment of virus diseases is achieved. However, at present, there are only related reports at home and abroad.

Disclosure of Invention

The invention aims to improve the prior art, and provides a preparation method of antibacterial and antiviral nano-material slurry, which is characterized by comprising the following sequential steps:

1. a preparation method of antibacterial and antiviral nano water-based slurry is characterized by comprising the following steps in sequence:

(1) preparing inorganic zinc salt and sodium hydroxide into aqueous solutions by using deionized water respectively, dropwise adding the inorganic zinc salt solution into the sodium hydroxide solution under the condition of magnetic stirring at the temperature of 60-90 ℃, controlling the pH value of the solution within the range of 11-13, and carrying out water bath heat preservation after dropwise adding; after the reaction is finished, the columnar nano ZnO powder is prepared after filtration, separation, drying and pyrolysis.

(2) Adding columnar nano ZnO powder into Cu₂SO₄Adding a certain amount of NaOH aqueous solution, CTAB aqueous solution, GO aqueous solution and hydrazine hydrate into the aqueous solution, carrying out ultrasonic mixing reaction, and then carrying out pyrolysis to obtain Cu₂O-ZnO-GO nano composite powder;

(3) mixing 0.5-3 wt% of titanate YY-2 coupling agent, 0.5-5 wt% of disodium coconut monoethanolamide sulfosuccinate surfactant, 0.3-0.5 wt% of polyethylene glycol dispersant and 50-60 wt% of polyacrylic acid binder to prepare a mixed dispersion solution;

(4) mixing Cu₂Adding the O-ZnO-GO nano composite powder into the mixed dispersion solution, and stirring to obtain the antibacterial and antiviral nano aqueous slurry.

The invention has the beneficial effects that:

1. the nano composite powder aqueous slurry has good stability, and does not generate layering and precipitate separation after standing for 30 days.

2. The Cu₂The O and ZnO columnar nano array structure simulates the nano raised structure on the dragonfly wing, and can induce non-enveloped virus due to oxidative stress effectIt is deformed and inactivated to achieve the effect of killing virus;

3. the average diameter of the nano composite material in the slurry is equivalent to the diameter of the virus, so that the small-size effect of the nano particles can be effectively exerted, the nano particles enter the inside of the virus, the structure of the virus is damaged, and the virus is effectively inactivated.

Detailed Description

The present invention is further illustrated by the following examples, which are intended to be purely exemplary and are not intended to limit the scope of the invention, as various equivalent modifications of the invention will occur to those skilled in the art upon reading the present specification and which fall within the limits of the appended claims.