阅读说明：本技术 一种新型口服补液盐散及其制备方法 (Novel oral rehydration salt powder and preparation method thereof ) 是由 张娜 蔡燕峰 李小玲 符友伟 谢治平 林健勇 叶燕军 张会会 于 2020-06-24 设计创作，主要内容包括：本发明公开了一种新型口服补液盐散及其制备方法,属于医药技术领域,该新型口服补液盐散按重量份计,包括6.2-6.5份的氯化钠、3.58-3.75份的氯化钾、6.98-7.25份的枸橼酸钠、18.20-20.33份的无水葡萄糖、5.5-6.2份的海藻糖和17.08-17.94份的牛蒡根冻干粉。该新型口服补液盐散不仅能够起到缓解腹泻带来的轻度、中度脱水问题,还能够有效缩短腹泻时间,减少排便量,增强胃肠修复功能,有利于加速腹泻患者的康复。该新型口服补液盐散的制备方法,能够显著提高混合物的流动性,保证所得粉剂混合的均匀度和良好的溶解性。(The invention discloses novel oral rehydration salt powder and a preparation method thereof, and belongs to the technical field of medicines, wherein the novel oral rehydration salt powder comprises, by weight, 6.2-6.5 parts of sodium chloride, 3.58-3.75 parts of potassium chloride, 6.98-7.25 parts of sodium citrate, 18.20-20.33 parts of anhydrous glucose, 5.5-6.2 parts of trehalose and 17.08-17.94 parts of burdock root freeze-dried powder. The novel oral rehydration salt powder can relieve mild and moderate dehydration problems caused by diarrhea, effectively shorten diarrhea time, reduce defecation amount, enhance gastrointestinal repair function, and is favorable for accelerating recovery of diarrhea patients. The preparation method of the novel oral rehydration salt powder can obviously improve the fluidity of a mixture and ensure the mixing uniformity and good solubility of the obtained powder.)

1. The novel oral rehydration salt powder is characterized by comprising, by weight, 6.2-6.5 parts of sodium chloride, 3.58-3.75 parts of potassium chloride, 6.98-7.25 parts of sodium citrate, 18.20-20.33 parts of anhydrous glucose, 5.5-6.2 parts of trehalose and 17.08-17.94 parts of burdock root freeze-dried powder.

2. The novel oral rehydration salt powder of claim 1, comprising, by weight, 6.4 parts of sodium chloride, 3.47 parts of potassium chloride, 7.13 parts of sodium citrate, 19.75 parts of anhydrous glucose, 5.6 parts of trehalose and 17.65 parts of burdock root lyophilized powder.

3. A preparation method of novel oral rehydration salt powder is characterized by comprising the following steps:

step 1, crushing the dried trehalose and the burdock root freeze-dried powder, and sieving the crushed powder with a sieve of 80-100 meshes for later use;

step 2, respectively crushing the dried sodium chloride, potassium chloride, sodium citrate and anhydrous glucose into powder with the particle size of less than 40 meshes, wherein particles with the particle size of less than 120 meshes account for 8-15%;

and 3, sequentially adding 18.20-20.33 parts by weight of anhydrous glucose, 17.08-17.94 parts by weight of burdock root freeze-dried powder, 6.98-7.25 parts by weight of sodium citrate, 6.2-6.5 parts by weight of sodium chloride, 5.5-6.2 parts by weight of trehalose and 3.58-3.75 parts by weight of potassium chloride which are processed in the step 1 and the step 2, and mixing to obtain a mixture.

4. The method for preparing the novel oral rehydration salt powder of claim 3, wherein the moisture content of the trehalose and the burdock root lyophilized powder in step 1 and the moisture content of the anhydrous glucose, the sodium citrate, the sodium chloride and the potassium chloride treated in step 2 are all less than 0.5%.

5. The method for preparing novel oral rehydration salt powder of claim 3, wherein the mixing time in step 3 is 40 min.

6. The method for preparing the novel oral rehydration salt powder of claim 3, further comprising the step 4 of subpackaging the mixture obtained in the step 3 according to 5.754-6.197 g/bag.

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to novel oral rehydration salt powder and a preparation method thereof.

Background

Oral Rehydration Salts (ORS) were recommended by the World Health Organization (WHO) for the treatment of mild and moderate dehydration resulting from acute diarrhea since the last 70 th century. Over 40 years, after The oral rehydration salt is widely used globally, The mortality rate of acute diarrhea is greatly reduced, The lives of millions of diarrhea patients in developing countries are saved, and The medical progress which is most great in The 20 th century is evaluated by The global authoritative medical special book, The Lancet (Lancet). Clinical application and practice summarization find that the oral rehydration salts I and II have obvious effects on correcting dehydration, but have obvious defects on curative effect and safety, the WHO advocates that countries research and adjust the original oral rehydration salts according to the hypotonic principle, and the hypotonic formula of the oral rehydration salts is announced in 2002; the formal issue of the official release on 23.3.2006 recommends the use of a new generation of oral rehydration salt, namely oral rehydration salt III, and the oral rehydration salt III realizes dual curative effects of fluid supplementation and diarrhea treatment for the first time, and is a replacement product for comprehensively replacing the traditional oral rehydration salt. WHO believes that the new generation of oral rehydration salt will better protect against acute diarrhea. The preferred and necessary medicine for other diarrheal patients except severe dehydration is oral rehydration salt.

Compared with the second generation, the third generation reduces the content of sodium chloride and glucose in the formula, is a low-sodium and low-osmotic formula, and reduces adverse reactions. Compared with the original formula, the traditional Chinese medicine composition can better treat acute diarrhea, can obviously reduce the need rate of intravenous fluid infusion, and is more favorable for clinical use. The III-generation oral rehydration salt mainly takes glucose, can correct and prevent water shortage caused by diarrhea, but cannot effectively improve the intestinal environment, shorten the diarrhea time or reduce the defecation amount. In order to solve the problem, researchers have developed improvements on the III-generation oral rehydration salt. For example, the Chinese patent with the application number of 201810771830.2 comprises the following components in terms of preparing 1000mL oral rehydration salt: sodium chloride, sodium citrate, potassium chloride, glucose, vitamin C and probiotic viable bacteria powder g; the probiotic live bacteria powder is prepared by mixing probiotic freeze-dried powder and porous starch and then extruding and embedding. The oral rehydration salt can replenish electrolytes and relieve diarrhea symptoms, has high probiotic survival rate, and has the effects of establishing intestinal flora and improving intestinal environment, so that patients can recover more quickly.

Disclosure of Invention

In order to overcome the defects of the prior art, the technical problems to be solved by the invention are as follows: provides a novel oral rehydration salt powder capable of improving intestinal environment and relieving diarrhea symptoms and a preparation method thereof.

In order to solve the technical problems, the invention adopts the technical scheme that: a novel oral rehydration salt powder comprises, by weight, 6.2-6.5 parts of sodium chloride, 3.58-3.75 parts of potassium chloride, 6.98-7.25 parts of sodium citrate, 18.20-20.33 parts of anhydrous glucose, 5.5-6.2 parts of trehalose and 17.08-17.94 parts of burdock root freeze-dried powder.

The other technical scheme adopted by the invention is as follows: a preparation method of novel oral rehydration salt powder comprises the following steps:

step 1, crushing the dried trehalose and the burdock root freeze-dried powder, and sieving the crushed powder with a sieve of 80-100 meshes for later use;

step 2, respectively crushing the dried sodium chloride, potassium chloride, sodium citrate and anhydrous glucose into powder with the particle size of less than 40 meshes, wherein particles with the particle size of less than 120 meshes account for 8-15%;

and 3, sequentially adding 18.20-20.33 parts by weight of anhydrous glucose, 17.08-17.94 parts by weight of burdock root freeze-dried powder, 6.98-7.25 parts by weight of sodium citrate, 6.2-6.5 parts by weight of sodium chloride, 5.5-6.2 parts by weight of trehalose and 3.58-3.75 parts by weight of potassium chloride which are processed in the step 1 and the step 2, and mixing to obtain a mixture.

The invention has the beneficial effects that: the novel oral rehydration salt powder provided by the invention uses trehalose and the burdock root freeze-dried powder to replace part of glucose, the burdock root freeze-dried powder is rich in various vitamins and mineral substances required by a human body, contains part of starch and various enzymes, is favorable for improving gastrointestinal functions and regulating the repair of gastrointestinal mucosa, and simultaneously compared with the direct use of glucose, the starch in the burdock root freeze-dried powder can achieve the effects of shortening diarrhea time and reducing defecation amount, and the share of trehalose can help to improve the micro-ecological environment in intestinal tracts, so that the proliferation of bifidobacteria and other beneficial bacteria is facilitated, the repair of the intestinal tract environment after diarrhea is accelerated, and the trehalose and the burdock root freeze-dried powder are stable in form, so that the novel oral rehydration salt powder is a powder, and the states of sodium chloride, potassium chloride, sodium citrate and anhydrous glucose cannot be influenced in the storage process, can be directly taken with warm water. The novel oral rehydration salt powder can relieve mild and moderate dehydration problems caused by diarrhea, effectively shorten diarrhea time, reduce defecation amount, enhance gastrointestinal repair function, and is favorable for accelerating recovery of diarrhea patients. The preparation method of the novel oral rehydration salt powder provided by the invention can obviously improve the fluidity of the mixture and ensure the mixing uniformity and good solubility of the obtained powder.

Detailed Description

In order to explain the technical content, the objects and the effects of the present invention in detail, the following description will be given with reference to the embodiments.

The most key concept of the invention is as follows: trehalose and burdock root freeze-dried powder are used for replacing part of glucose, so that the effect of oral rehydration salt is improved.

The invention provides novel oral rehydration salt powder which comprises, by weight, 6.2-6.5 parts of sodium chloride, 3.58-3.75 parts of potassium chloride, 6.98-7.25 parts of sodium citrate, 18.20-20.33 parts of anhydrous glucose, 5.5-6.2 parts of trehalose and 17.08-17.94 parts of burdock root freeze-dried powder.

From the above description, the beneficial effects of the present invention are: according to the novel oral rehydration salt powder provided by the invention, trehalose and the burdock root freeze-dried powder are used for replacing part of glucose, the burdock root freeze-dried powder is rich in potassium and other mineral substances, and simultaneously contains part of starch and multiple enzymes, so that the gastrointestinal function is improved, the gastrointestinal mucosa repair is facilitated to be adjusted, and compared with the direct use of glucose, the starch in the burdock root freeze-dried powder can achieve the effects of shortening the diarrhea time and reducing the defecation amount; trehalose compensates for the loss of sweetness after glucose reduction and is difficult to hydrolyze by salivary and small intestine digestive enzymes, providing sweetness with little conversion to fat. Meanwhile, the trehalose and the burdock root freeze-dried powder are stable in form, the obtained novel oral rehydration salt powder is powder, the states of sodium chloride, potassium chloride, sodium citrate and anhydrous glucose cannot be influenced in the storage process, and the oral rehydration salt powder can be directly taken with warm water. The novel oral rehydration salt powder can relieve mild and moderate dehydration problems caused by diarrhea, effectively shorten diarrhea time, reduce defecation amount, enhance gastrointestinal repair function, and is favorable for accelerating recovery of diarrhea patients.

Further, the novel oral rehydration salt powder comprises, by weight, 6.4 parts of sodium chloride, 3.47 parts of potassium chloride, 7.13 parts of sodium citrate, 19.75 parts of anhydrous glucose, 5.6 parts of trehalose and 17.65 parts of burdock root freeze-dried powder.

The invention provides a preparation method of novel oral rehydration salt powder, which comprises the following steps:

step 1, crushing the dried trehalose and the burdock root freeze-dried powder, and sieving the crushed powder with a sieve of 80-100 meshes for later use;

step 2, respectively crushing the dried sodium chloride, potassium chloride, sodium citrate and anhydrous glucose into powder with the particle size of less than 40 meshes, wherein particles with the particle size of less than 120 meshes account for 8-15%;

and 3, sequentially adding 18.20-20.33 parts by weight of anhydrous glucose, 17.08-17.94 parts by weight of burdock root freeze-dried powder, 6.98-7.25 parts by weight of sodium citrate, 6.2-6.5 parts by weight of sodium chloride, 5.5-6.2 parts by weight of trehalose and 3.58-3.75 parts by weight of potassium chloride into the multidirectional motion mixer, and mixing to obtain a mixture.

From the above description, the beneficial effects of the present invention are: the novel oral rehydration salt powder is powder, the problems of agglomeration and uneven dispersion are easy to occur in the preparation process, the smaller the granularity of the material is, the poorer the fluidity of the material is, but the overlarge granularity can influence the solubility of the material in water, particles smaller than 120 meshes are controlled within 8-15% by crushing the sodium chloride, the potassium chloride, the sodium citrate and the anhydrous glucose into 40 meshes and sieving the particles, and the mixture is matched with a method for gradually adding and mixing the raw materials in sequence in distribution, so that the fluidity of the mixture can be obviously improved, and the mixing uniformity and the good solubility of the obtained powder are ensured.

Further, the water content of the trehalose, the burdock root freeze-dried powder in the step 1 and the water content of the anhydrous glucose, the sodium citrate, the sodium chloride and the potassium chloride which are processed in the step 2 are all less than 0.5 percent.

Further, the mixing time in the step 3 is 40 min.

Further, the preparation method of the novel oral rehydration salt powder also comprises a step 4 of subpackaging the mixture obtained in the step 3 according to 5.754 to 6.197 g/bag.