阅读说明：本技术 一种灭活病毒阻断感染汽化疗法的中药组方 (Traditional Chinese medicine formula for inactivating virus and blocking infection vaporization therapy ) 是由 张文举 张嘉馨 张嘉乐 王皓 于 2020-04-01 设计创作，主要内容包括：本发明是一种以病毒传播感染途径为追踪路径进行病毒灭活,同时辅助人体受病毒感染损伤器官、组织维持正常功能以抵抗感染症状恶化,避免“免疫风暴”发生的纯中草药汽化疗法的组方。通过口鼻粘膜吸收药物有效成分并最终作用于肺脏。不仅在治疗时间上抢先病毒感染速度,还能够在感染期间起到辅助增强肺脏各项功能恢复。(The invention relates to a prescription of a pure Chinese herbal medicine gasification therapy, which carries out virus inactivation by taking a virus transmission infection path as a tracking path, and simultaneously assists the organs and tissues of a human body which are infected by virus to maintain normal functions so as to resist the worsening of infection symptoms and avoid the occurrence of immune storm. The effective components of the medicine are absorbed through oral and nasal mucosa and finally act on the lung. Not only preempts the virus infection speed in the treatment time, but also plays a role in assisting and enhancing the recovery of various functions of the lung during the infection period.)

1. The invention relates to a traditional Chinese medicine formula for an inactivated virus blocking infection vaporization therapy, in particular to a traditional Chinese medicine formula for a mouth-nose inhalation type inactivated virus blocking infection vaporization therapy. The formula comprises the following components in percentage by weight: 20-35% of rhizoma atractylodis, 20-30% of pogostemon cablin, 15-25% of orange peel, 8-15% of platycodon grandiflorum, 5-15% of divaricate saposhnikovia root, 5-15% of polygala tenuifolia, 5-15% of rhodiola rosea and pure grain brewed white spirit (the specific dosage is based on the medicines soaked in the wine).

2. According to claim 1: the invention relates to a traditional Chinese medicine formula for an inactivated virus blocking infection vaporization therapy, in particular to a traditional Chinese medicine formula for a mouth-nose inhalation type inactivated virus blocking infection vaporization therapy. When the formula is used, Chinese herbal medicines with aromatic odor, such as schizonepeta, sandalwood, lavender, roses, lemon grass and mint, can be added according to the needs of users.

Technical Field

The invention relates to a traditional Chinese medicine formula for a vaporization therapy, in particular to a traditional Chinese medicine formula for a vaporization therapy for inactivating viruses and blocking infection.

Technical Field

The clinical manifestations of patients after infection with the novel coronavirus are: (1) fever, weakness, dry cough, and gradually dyspnea; some patients have slight symptoms of illness and even no obvious fever. The severe symptoms are: dyspnea or hypoxemia, acute respiratory distress syndrome, septic shock, uncorrectable metabolic acidosis, procoagulant dysfunction, (2) has pneumographic features: the early stage shows many small spots and changes of the interstitium, which is obvious in the extrapulmonary zone. Further developing into double lung multiple abrasion glass shadow and infiltration shadow, and severe patients can have lung excess change; (3) the total number of leukocytes in the early stages of onset is normal or reduced, or the lymphocyte count is reduced. Some patients also present with gastrointestinal symptoms such as diarrhea or keratitis. The new coronary pneumonia has the prominent characteristics that: the small airway has much mucus and high viscosity, which obstructs the airway to be unobstructed, thereby causing secondary infection and more serious infection. The death causes of the infection of the patients with the novel coronavirus are 4 types:

(1) the reduction of various functions of the body caused by excessive fear after the generation of infection reaction

(2) Aggravating the basic disease attack of internal organ injury after infection of virus

(3) The function of the respiratory system is reduced after the infection of virus, and the sputum thrombus blocks the respiratory tract to cause respiratory failure so as to reduce the blood oxygen content

(4) Acute respiratory distress syndrome and multiple organ failure caused by immune storm

Of the four causes of death, the death caused by the 'immune storm' is the most number of death patients, and the 'immune storm' is also the stage in which any treatment method cannot be reversed in the later stage of the novel coronavirus infection.

According to the respiratory system structure of human body, the path of virus entering human body through respiration and infecting is: nasal cavity, pharynx, laryngeal cavity, trachea, bronchi, lungs. Among them, the viscous liquid secreted from goblet cells in the trachea and bronchi in the respiratory system plays a role in moistening the air entering the lungs and adhering dust and microorganisms in the air. Ciliated cells gradually push mucus, which contains dust and microorganisms, to the pharynx by swinging in order. Subsequently, the mucus is expectorated by the body or swallowed into the stomach. However, when the virus invades respiratory tract to cause inflammation, the congestion and edema of the mucous membranes of the trachea and the bronchus are caused, and the secretion of mucus is increased; the immune system of the human body will be antiviral. In confrontation, DNA "leaks" out after damaged cells are damaged; the free DNA, after binding to mucin in the mucus, becomes a viscous substance. The viscosity is increased, and ciliated cells cannot normally swing to clean the ciliated cells, so that the sputum stops storing and coagulating. This is often referred to as sputum. Thus normal persons are normally free of sputum. The reason why sputum actually causes diseases is because sputum has the characteristic of 'traveling along with qi without place'. The sputum also can be pushed to move along with the transportation and transformation of the air in the human body, and the blockage at any position can cause the corresponding tissues to block the organs to generate pathological changes, and the respiratory tract blockage can cause respiratory failure.

The disease mainly affects cellular immunity in two aspects: problem of latent infection: the virus is proliferated when entering a human body, firstly, the proliferation results in low immunity and abnormal immunity in lymphocytes and tissues, and then lung damage occurs, and fever and cough occur. ② the mixed nature and complexity of lung infection, which is often seen in patients with low immunity. The current treatment for "immune storms" is by hormonal or antibiotic treatment, both of which ultimately cause irreversible life-long harm to the patient.

In conclusion, the last fatal attack of the novel coronavirus on patients is caused by excessive immune response of human body. Because of the differences in constitution among individuals, the time and extent from the onset of viral infection to the development of an "immune storm" vary. The treatment period is therefore calculated based on the current time of day the patient responded to the virus infection. This period from infection by the virus to the onset of an "immune storm" is the incubation and progression of the virus in humans. As can be seen from the real-time cases, the shortest time from the positive detection of infection in the hospital to the death is about one week. Plus at least about ten days from the onset of symptoms of infection to hospital examinations. At least ten days before the "immune storm" occurs can be used to prevent the infection from worsening, calculated on the basis of the time of the patient with the fastest rate of infection, ten days with a correct and effective treatment being sufficient to avoid life risks.

Depending on the route and symptoms of the viral infection, it can be attributed:

(1) infection from the mucosal tissues of the oral cavity, nasal cavity or conjunctiva of the eye enters the respiratory system or directly from the surface of damaged skin into the blood. The immune response in the human body at this time is: mild immune reactions such as fever, dry cough and hypodynamia.

(2) The virus enters the lung and then becomes difficult to breathe, fails to breathe and has reduced blood oxygen content

(3) Patients with severe infection develop symptoms such as respiratory failure, shock, renal insufficiency, etc.

All patients had fixed pathways for viral infection and invasive organs, all from the nasal cavity into the respiratory system to the lungs. In the respiratory system, the structure in the nasal cavity of a human body is very complex, and viruses can exist in places where air can enter. The conventional nasal cavity cleaning and administration mode can only be used at the superficial part of the nasal cavity, and the medicine cannot be delivered to the deep part of the nasal cavity and cannot be applied to the fine part in the nasal cavity. Therefore, the treatment mode of utilizing the gas medicine is only one mode which can directly reach the lung through the nasal cavity, and the medicine can act on any one fine part of the whole nasal cavity, and no danger can be caused in the process that the gas medicine reaches the lung and acts.

The surface area of the human nasal mucosa is about 150cm²The mucosa has a plurality of micro fluff, which greatly increases the effective area of drug absorption; the mucous membrane layer of the nasal cavity is very thin, abundant blood vessels and lymphatic vessels exist under the mucous membrane, and drug molecules are easy to absorb through the mucous membrane of the nasal cavity; in addition, the metabolic action of enzymes in the nasal cavity is very small. The nasal mucosa immunity is different from other part immunity, not only can induce local mucosa immune response, but also can induce system immune response, and the immune effect is similar to that of subcutaneous injection immunity. The medicine can directly enter human body circulation after being absorbed through nasal mucosa. Therefore, the speed of nasal mucosa absorption is far higher than the pathogenic speed of virus infection, and the mucosal absorption metabolic process is different from the liver metabolic process, so that the negative factors of drug absorption such as the first pass effect of the liver, gastrointestinal damage and other drug interaction can be avoided, and the drugs can be fully absorbed and utilized.

The invention uses ethanol to dissolve out the effective components in the medicine, and can be dispersed in the air by virtue of the volatilization potential of the ethanol and enter the lung through a respiratory tract. Modern medicine proves that ethanol can dissolve the mantle of new coronavirus to inactivate the virus, and ethanol molecules enter the lung through the respiratory system inhaled by a human body through the same path as the virus infection path, so that the ethanol can inhibit and inactivate the virus to a certain extent in the inhalation process. Ethanol inhaled by mouth and nose does not undergo the process of metabolic transformation of internal organs, and acetaldehyde is not generated, so that the human body is not damaged by the inhalation of mouth and nose.

In the process of inactivating viruses by ethanol, the effective components of the medicine are fully separated out by the ethanol and then are inhaled into the nasal cavity along with ethanol molecules through a respiratory system to act on mucosal tissues, and the effect of assisting the lung to maintain a normal working state is achieved after the absorption by a human body, so that the symptoms of unsmooth respiration, blood oxygen content reduction and the like caused by phlegm stagnation formed by lung dysfunction are avoided, and finally the fatal risk of 'immune storm' is avoided.

Disclosure of Invention

The invention relates to a Chinese herbal medicine formula for vaporization therapy, which carries out virus inactivation by taking a virus transmission infection way as a tracking path, simultaneously assists the damaged organs of a human body to maintain normal functions, eliminates free radicals and avoids immune storm. The effective components of the medicine are inhaled and absorbed through mouth and nose and finally act on the lung. Not only preempts the virus infection speed in time, but also can assist and strengthen various functions of the lung during the infection period, and can not cause damage to any organ or tissue. The main raw materials involved in the invention are: rhizoma atractylodis, pogostemon cablin, orange peel, platycodon grandiflorum, radix sileris, polygala tenuifolia, rhodiola rosea and the like. The formula comprises the following components in percentage by weight: 20-35% of rhizoma atractylodis, 20-30% of pogostemon cablin, 15-25% of orange peel, 8-15% of platycodon grandiflorum, 5-15% of divaricate saposhnikovia root, 5-15% of polygala tenuifolia and 5-15% of rhodiola rosea

As a preferred embodiment: when the formula is implemented specifically, Chinese herbal medicines with aromatic odor such as herba schizonepetae, sandalwood, lavender, rose, lemon grass and mint can be added according to the needs of users.

Rhizoma atractylodis: as early as in the Han dynasty, Zhang Zhongjing says that rhizoma Atractylodis can avoid all bad breath, and Ming Dynasty Li Shizhen also records that rhizoma Atractylodis can remove bad breath, diseases and senile denier, and tends to burn rhizoma Atractylodis to avoid pathogenic qi when entering home, so that the disease of epidemic is used more. The record of Zhang shan Lei (materia Medica) in recent times: cang Zhu is fragrant and can avoid foul smell and surpass the qi of four seasons, so it is used for epidemic diseases. Most effectively removing foul and foul smell. In the area of haze, it is advisable to burn the material in a long-term open room and then live in the house.

And (3) jojoba leaf: the volatile oil in herba Agastaches has effects of stimulating gastric mucosa, promoting gastric secretion, and promoting digestion. The flavonoids in herba Agastaches have antiviral effect, and the components separated from herba Agastaches can inhibit growth and reproduction of virus as pathogen in digestive tract and upper respiratory tract. The invention can treat diarrhea caused by virus infection to intestines and stomach, and can inhibit the growth and reproduction of virus in respiratory tract and digestive tract.

Orange peel: the formula of the invention has the functions of regulating qi and freeing lung, and can achieve the effect of assisting the recovery of lung function. The orange peel contains a large amount of vitamin C, has an antioxidation effect, and can resist the damage of oxygen radicals to infected organs in the virus reproduction process.

Balloon flower: disperse lung qi, dispel phlegm.

Wind prevention: the formula of the invention has the functions of removing dampness, relieving pain and resisting virus.

Polygala root: polygala tenuifolia has the effect of eliminating phlegm, and researches show that saponin contained in the polygala tenuifolia can stimulate gastric mucosa so as to reflectively promote the increase of bronchial secretion, thereby achieving the effect of improving cough and eliminating phlegm.

Rhodiola root: has effects in inhibiting center, tonifying heart, relieving inflammation, resisting virus, regulating gastrointestinal function, clearing lung-heat, and relieving cough. The rhodiola rosea can effectively treat cough caused by lung heat, accompanied by thick and yellow phlegm, asthma, coarse cough, high fever, thirst, dysphoria, even fantasy nasal wings, epistaxis, hemoptysis and the like. Therefore, the rhodiola rosea has the effect of treating the pulmonary tuberculosis. In recent years, intensive research on rhodiola rosea has been carried out by pharmaceutical workers at home and abroad, and it is proposed that rhodiola rosea has the function of ' adapting to original shape ' similar to ginseng ' for strengthening body resistance and consolidating constitution, is superior to ginseng in certain aspects, and does not have the defect of over-strong excitation function of ginseng. The effective components of radix Rhodiolae have effects of tonifying heart, tranquilizing mind, regulating metabolism, regulating nervous system and endocrine system, and regulating blood sugar and blood pressure, and can be used for treating cerebrovascular diseases, senile myocardial failure, diabetes, hypotension, asthenia after illness, senile asthenia, and neurasthenia. The modern practical materia Medica says that the action of the Chinese herbal medicine is seven, namely, the action of inhibiting the central nervous system. Secondly, the anti-fatigue effect. Thirdly, strengthening the heart. Fourthly, anti-inflammatory action. And fifthly, inhibiting the blood sugar rise. Sixthly, resisting peroxidation. Seventhly, microwave radiation resisting effect. Rhodiola rosea promotes the tolerance of people to an anoxic environment. The rhodiola rosea can help us to improve the effect of combining hemoglobin and oxygen, so that the rhodiola rosea can also help us to improve the blood oxygen saturation, and can adjust a human body and adapt to the oxygen-deficient environment to improve the body discomfort caused by oxygen deficiency in the oxygen-deficient environment. The invention can avoid the lung dysfunction and the symptom of cardiovascular and cerebrovascular diseases caused by virus infection, and can relieve the symptom of blood oxygen content reduction of patients after virus infection. The intervention form is used for assisting to improve the virus resistance of the patient after infection.

Herba schizonepetae: the formula of the invention has the effects of dispersing lung qi, eliminating dampness, transporting and transforming spleen and stomach, and the like.

The invention relates to a pure traditional Chinese medicine inactivation infection blocking formula absorbed by mucosa and a using method thereof, and the action mechanism is as follows:

1. the effective components of the medicine are directly absorbed by mucosa tissues directly contacting the outside, enter blood and directly reach focuses and act on the focuses. In the process, viruses entering the human body through the mucosa are subjected to targeted inactivation and virus propagation is inhibited, the burden of immune response of the human body is relieved, and mucus secretion of a respiratory system is reduced.

2. Dispersing lung qi, eliminating phlegm, and increasing blood oxygen content. The lung is assisted by the effective components of the medicine to recover the function of the lung, effectively accelerate the discharge of sputum, dredge qi activity and recover oxygen transportation to avoid oxygen deficiency.

3. Strengthening the spleen and stomach, recovering diet and supplementing nutrition, ensuring sufficient energy to assist the immune system to resist virus, and recovering the normal operation of various functions of the human body.

The efficacy of the medicines for resisting epidemic diseases is obtained by ancient medical experience, and then the medicines are prepared by the inventor according to the virus transmission path and infection symptoms and the innovative combination of the disease-causing prescription.

Detailed description of the preferred embodiments