阅读说明：本技术 一种低粘度的海盐口腔护理漱口水 (Low-viscosity sea salt oral care mouth wash ) 是由 蓝一蕊 梁小琪 于 2020-07-21 设计创作，主要内容包括：本发明提供了一种低粘度的海盐口腔护理漱口水,包括山梨醇5-7份,甘油0.8-1.2份,PEG-40氢化蓖麻油2.0-2.6份,(1R,2S,5R)-N-(4-(氰基甲基)苯基)-2-异丙基-5-甲基环己烷甲酰胺0.05-0.10份,薄荷香精0.08-0.11份,丁香油0.009-0.011份,丹皮酚0.04-0.06份,葡萄香精0.13-0.15份,山梨酸钾0.4-0.6份,木糖醇2-4份,长芦精盐1.0-1.4份,柠檬酸0.01-0.03份,野菊花提取液0.3-0.5份,甘草提取液0.3-0.4份,绿茶提取液0.3-0.4份,薄荷提取物0.3-0.4份,增稠物0.2-2份以及蜂胶粉0.05-0.1份,水83-85份。本发明研发的口腔护理漱口水,其是低粘度溶液,通过配方组分选择和含量优化,具有高悬浮力与高流动性。配方中不含酒精,对于难溶于水的固态物质可悬浮在漱口水中,加大了漱口水的应用范围和使用体验。(The invention provides a low-viscosity sea salt oral care mouthwash, which comprises 5-7 parts of sorbitol, 0.8-1.2 parts of glycerol, 2.0-2.6 parts of PEG-40 hydrogenated castor oil, (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 0.05-0.10 part of mint essence, 0.08-0.11 part of mint essence, 0.009-0.011 part of clove oil, 0.04-0.06 part of paeonol, 0.13-0.15 part of grape essence, 0.4-0.6 part of potassium sorbate, 2-4 parts of xylitol, 1.0-1.4 parts of radix rhapontici Japonici refined salt, 0.01-0.03 part of citric acid, 0.3-0.5 part of wild chrysanthemum flower extract, 0.3-0.4 part of licorice extract, 0.3-0.4 part of green tea extract, 0.3-0.4 part of mint extract, 0.2-2.05-0.05 part of propolis thickener and 0.05-0.6 part of propolis powder, and 83-85 parts of water. The oral care mouth wash developed by the invention is a low-viscosity solution, has high suspension force and high fluidity through formula component selection and content optimization. The formula does not contain alcohol, and solid substances which are difficult to dissolve in water can be suspended in the mouthwash, so that the application range and the use experience of the mouthwash are enlarged.)

1. A low-viscosity sea salt oral care mouth wash is characterized by comprising the following raw materials in parts by weight: 5-7 parts of sorbitol, 0.8-1.2 parts of glycerol, 2.0-2.6 parts of PEG-40 hydrogenated castor oil, (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 0.05-0.10 part of mint essence, 0.08-0.11 part of clove oil, 0.009-0.011 part of paeonol, 0.04-0.06 part of paeonol, 0.13-0.15 part of grape essence, 0.4-0.6 part of potassium sorbate, 2-4 parts of xylitol, 1.0-1.4 parts of long reed rhizome salt, 0.01-0.03 part of citric acid, 0.3-0.5 part of wild chrysanthemum flower extract, 0.3-0.4 part of liquorice extract, 0.3-0.4 part of green tea extract, 0.3-0.4 part of mint extract, 0.2-2 parts of thickener, 0.05-0.1.83-85 parts of anti-inflammatory bactericidal component and water;

the thickener is prepared by mixing hyaluronic acid, xanthan gum and hydroxyethyl cellulose, wherein the mass ratio of the hyaluronic acid to the xanthan gum to the hydroxyethyl cellulose is 1.5-4: 1: 0.5 to 2; the anti-inflammatory and bactericidal component is propolis powder which is prepared by fully mixing a pure propolis extract subjected to lead removal with microcrystalline cellulose, and crushing and sieving.

2. The low viscosity sea salt oral care mouth rinse of claim 1 wherein the rhaponticum salt is a seawater salt produced by the Tianjin rhaponticum.

3. The low viscosity sea salt oral care mouth rinse of claim 1 wherein the thickener is a mixture of hyaluronic acid and xanthan gum, hydroxyethyl cellulose in a mass ratio of 2: 1: 0.8 of the components.

4. The low viscosity sea salt oral care mouth rinse of claim 1, wherein the mouth rinse is comprised of the following raw materials in parts by weight: 5-7 parts of sorbitol, 0.8-1.2 parts of glycerol, 2.0-2.6 parts of PEG-40 hydrogenated castor oil, (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 0.05-0.10 part of mint essence, 0.08-0.11 part of clove oil, 0.009-0.011 part of paeonol, 0.04-0.06 part of paeonol, 0.13-0.15 part of grape essence, 0.4-0.6 part of potassium sorbate, 2-4 parts of xylitol, 1.0-1.4 parts of long reed rhizome salt, 0.01-0.03 part of citric acid, 0.3-0.5 part of wild chrysanthemum flower extract, 0.3-0.4 part of liquorice extract, 0.3-0.4 part of green tea extract, 0.3-0.4 part of mint extract, 0.2-2 parts of thickener, 0.05-0.83-85 parts of anti-inflammatory bactericidal component and water.

5. The low viscosity sea salt oral care mouth rinse of claim 4, wherein the mouth rinse is comprised of the following raw materials in parts by weight: 6 parts of sorbitol, 1.0 part of glycerol, 2.3 parts of PEG-40 hydrogenated castor oil, (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 0.105 part of mint essence, 0.01 part of clove oil, 0.05 part of paeonol, 0.14 part of grape essence, 0.5 part of potassium sorbate, 3 parts of xylitol, 1.2 parts of rhaponticum uniflorum salt, 0.02 part of citric acid, 0.4 part of wild chrysanthemum flower extract, 0.3 part of liquorice extract, 0.3 part of green tea extract, 0.3 part of mint extract, 1.0 part of thickener, 0.08 part of anti-inflammatory and bactericidal component and 84 parts of water.

6. The low-viscosity sea salt oral care mouth wash of claim 1, wherein the propolis powder comprises 90-70 wt% of propolis extract and 10-30 wt% of microcrystalline cellulose.

7. The low viscosity sea salt oral care mouth rinse of claim 6 wherein the propolis powder is prepared by a process comprising the steps of:

s1, fully mixing the pure propolis extract subjected to lead removal with microcrystalline cellulose to obtain a mixture;

s2, circularly crushing the mixture through airflow, wherein the flow rate of the airflow is 8-12m³Min, the exhaust pressure is 1.0 Mpa;

s3, screening, namely screening the crushed mixture by using a screening tool;

s4, placing the sieved mixture into a mixer, and uniformly stirring the mixture to obtain the propolis powder with the fineness of 200-250 meshes.

8. The low viscosity sea salt oral care mouth rinse of claim 1 wherein the wild chrysanthemum extract, licorice extract, green tea extract and mint extract are all liquid and have good compatibility with water.

9. The low viscosity sea salt oral care mouth rinse of claim 1 wherein the mouth rinse has a viscosity of less than 280mpa.s at a rheometer speed of 7 r/min.

10. A process for preparing a low viscosity sea salt oral care mouth rinse of any of claims 1 to 9 comprising the steps of:

adding sorbitol, glycerol and PEG-40 hydrogenated castor oil into water in a sterile room, uniformly stirring, adding (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, mint essence, clove oil, paeonol, grape essence, potassium sorbate, xylitol, rhaponticum uniflorum salt, citric acid, wild chrysanthemum flower extract, liquorice extract, green tea extract and mint extract, fully dissolving and uniformly stirring, finally adding an anti-inflammatory and bactericidal component and a thickening agent, and uniformly stirring to obtain the low-viscosity sea salt oral care mouthwash.

Technical Field

The invention belongs to the technical field of oral cleaning products, and particularly relates to a sea salt oral care mouthwash with low viscosity and a preparation method thereof.

Background

The oral health status is a mirror reflecting the quality of life and health. In recent years, oral hygiene issues have become more and more important. The focus of oral hygiene is to control plaque, eliminate dirt and food debris, enhance physiological stimulation, and provide a clean and healthy environment for the oral cavity, thereby exerting its physiological functions and maintaining oral health. The oral cavity which is contacted with food every day is a hotbed of bacteria, and the bacteria in the oral cavity easily cause common oral diseases such as tooth decay and periodontal disease. More than six hundred kinds of bacteria exist in the oral cavity, and common carbon dioxide sputogenes (Capnocytophaga sputigena), Lactobacillus brevis (Lactobacillus brevis), Staphylococcus aureus (Staphylococcus aureus), Streptococcus mutans (Streptococcus mutans), Streptococcus oralis (Streptococcus oralis), Escherichia coli (Escherichia coli), Pseudomonas aeruginosa (Pseudomonas aeruginosa), and Streptococcus thermophilus (Streptococcus thermophilus), etc. However, toothbrushes only clean 50% of the tooth surface, while other parts require the assistance of dental floss and mouthwash. The mouthwash can penetrate into various parts of the oral cavity, reduce bacteria and bacterial plaque causing halitosis, and improve the health of the gum.

Propolis (proplis) is a gum solid with aromatic odor, which is obtained by collecting the bud secretion of the plant or the resin flowing out of the wound of a bee, and mixing the bud secretion with the jaw gland secretion. Propolis contains a large amount of flavonoids, aromatic acids, fatty acids and terpene compounds. The propolis contains effective substances such as flavonoids, flavonol, terpenes, enzymes, multiple vitamins, polyphenols, polysaccharides, resins, organic acids and the like, and has good effects in improving immunity, preventing tumors, resisting oxidation, protecting liver, reducing blood fat, reducing blood sugar, resisting bacteria, diminishing inflammation, resisting viruses, treating various skin diseases, digestive and urinary system diseases, bronchitis, tumors, oral ulcer and the like. However, propolis is applied to mouthwash, is suitable for alcohol-containing mouthwash due to its poor solubility, and is easily precipitated. Patent CN201611012377.4 discloses a propolis type plant antibacterial mouth wash and a preparation method thereof, which comprises the following raw materials by mass percent: 2-5% of supercritical propolis extract, 15-25% of Chinese herbal medicine extract, 0.3-0.5% of essential oil mixture, 10-20% of edible ethanol, 4-8% of synergist vitamin complex and the balance of deionized water; adding the compound essential oil and the propolis extract into edible ethanol, and uniformly mixing to obtain a mixture A; adding the compound vitamin into deionized water, adding the Chinese herbal medicine extract, and uniformly stirring to obtain a mixture B; mixing the mixture A, B, adding deionized water, and stirring to obtain collutory. In the formula of the mouthwash, alcohol is used, the irritation to the oral cavity is large, the propolis needs to be subjected to supercritical extraction to obtain a liquid extract, the process is complex, and the cost is high.

When propolis which is difficult to dissolve in water is added into the nonalcoholic mouthwash, a proper suspension system is required to be uniformly dispersed in the mouthwash; however, the prior art cannot give consideration to better suspending of propolis in a mouthwash system and ensuring the fluidity of the mouthwash. Therefore, the research and development of the oral care mouthwash with low viscosity have certain viscosity, ensure the fluidity of the mouthwash and have great market value.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a sea salt oral care mouthwash with low viscosity, which has certain viscosity, ensures the fluidity of the mouthwash and can suspend insoluble substances. The formula of the mouthwash provided by the invention does not contain alcohol, contains various active ingredients, and can sterilize and diminish inflammation and protect oral health.

In order to achieve the purpose, the invention adopts the following technical scheme:

a low viscosity sea salt oral care mouth rinse comprising the following raw materials in parts by weight: 5-7 parts of sorbitol, 0.8-1.2 parts of glycerol, 2.0-2.6 parts of PEG-40 hydrogenated castor oil, (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 0.05-0.10 part of mint essence, 0.08-0.11 part of clove oil, 0.009-0.011 part of paeonol, 0.04-0.06 part of paeonol, 0.13-0.15 part of grape essence, 0.4-0.6 part of potassium sorbate, 2-4 parts of xylitol, 1.0-1.4 parts of long reed rhizome salt, 0.01-0.03 part of citric acid, 0.3-0.5 part of wild chrysanthemum flower extract, 0.3-0.4 part of liquorice extract, 0.3-0.4 part of green tea extract, 0.3-0.4 part of mint extract, 0.2-2 parts of thickener, 0.05-0.1.83-85 parts of anti-inflammatory bactericidal component and water;

the thickener is prepared by mixing hyaluronic acid, xanthan gum and hydroxyethyl cellulose, wherein the mass ratio of the hyaluronic acid to the xanthan gum to the hydroxyethyl cellulose is 1.5-4: 1: 0.5 to 2; the anti-inflammatory and bactericidal component is propolis powder which is prepared by fully mixing a pure propolis extract subjected to lead removal with microcrystalline cellulose, and crushing and sieving.

In the formula of the mouthwash disclosed by the invention, (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide is a substance capable of bringing long-acting cooling, mint essence can bring cooling and fragrance of mint, clove oil has the effects of diminishing inflammation and stopping bleeding, and paeonol has the effects of diminishing inflammation, relieving swelling and pain, resisting allergy, resisting viruses and the like. The grape essence improves the fragrance and taste of the mouthwash, the rhaponticum uniflorum refined salt has the effects of resisting bacteria, reducing internal heat and diminishing inflammation, the wild chrysanthemum flower extracting solution has the effects of dispelling wind and clearing heat, reducing swelling and detoxifying, the liquorice extracting solution treats swollen sore throat and peptic ulcer, the green tea extracting solution has the medicinal effects of refreshing and clearing away the heart-fire, clearing away summer-heat, helping digestion and reducing phlegm, removing greasiness and losing weight, clearing away the heart-fire and relieving restlessness, detoxifying and sobering up, promoting the production of body fluid to quench thirst, reducing internal heat and improving eyesight, stopping dysentery and removing. Effective substances in propolis, such as flavonoids, flavonols, terpenes, enzymes, various vitamins, polyphenols, polysaccharides, resins, organic acids and the like, are widely applied to the fields of antibacterial and anti-inflammatory toothpaste, antibacterial soap, cosmetics and the like. The propolis powder can sterilize, disinfect and inhibit bacteria, has no side effect, can promote cell tissue regeneration, particularly has good repairing effect on oral diseases, and can also be used for treating oral ulcer. The selection and content setting of the components are that the components are mutually matched through different action mechanisms to achieve the purposes of resisting bacteria, diminishing inflammation, clearing heat, purging fire and detoxifying.

The oral care mouth wash developed by the invention is a low-viscosity solution, has high suspension force and high fluidity through formula component selection and content optimization. The mouthwash needs better fluidity and lower viscosity to have no sticky feeling, but the propolis powder cannot be suspended if the suspension force is small, and the propolis powder can settle to the bottom of the mouthwash. If the suspending force of the mouthwash is increased to enable the mouthwash to suspend the propolis powder, the viscosity of the mouthwash can be increased, so that the mouth feel of the mouthwash is not moist and thick and refreshing. Through long-term experiments, the inventor finds that a certain amount of hyaluronic acid, xanthan gum and hydroxyethyl cellulose are added into the mouthwash for compounding and adjusting, so that the mouthwash can meet the requirement of low viscosity and can suspend the xanthan gum powder, and the mass ratio of the hyaluronic acid to the xanthan gum to the hydroxyethyl cellulose is 1.5-4: 1: the effect is excellent when the dosage is 0.5-2.

Preferably, the thickener is prepared by mixing hyaluronic acid, xanthan gum and hydroxyethyl cellulose according to a mass ratio of 2: 1: 0.8 of the components. The mass ratio of hyaluronic acid to xanthan gum to hydroxyethyl cellulose is 2: 1: when 0.8, the mouthwash can uniformly suspend the propolis powder, the propolis powder is optimally uniformly distributed, and the influence of the fluidity of the mouthwash is small.

Preferably, the mouthwash consists of the following raw materials in parts by weight: 5-7 parts of sorbitol, 0.8-1.2 parts of glycerol, 2.0-2.6 parts of PEG-40 hydrogenated castor oil, (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 0.05-0.10 part of mint essence, 0.08-0.11 part of clove oil, 0.009-0.011 part of paeonol, 0.04-0.06 part of paeonol, 0.13-0.15 part of grape essence, 0.4-0.6 part of potassium sorbate, 2-4 parts of xylitol, 1.0-1.4 parts of long reed rhizome salt, 0.01-0.03 part of citric acid, 0.3-0.5 part of wild chrysanthemum flower extract, 0.3-0.4 part of liquorice extract, 0.3-0.4 part of green tea extract, 0.3-0.4 part of mint extract, 0.2-2 parts of thickener, 0.05-0.83-85 parts of anti-inflammatory bactericidal component and water. The ingredient selection and the content proportion of the formula are obtained by long-term experimental adjustment of the inventor, and the prepared mouthwash achieves the purposes of resisting bacteria, diminishing inflammation, clearing heat, purging fire and detoxifying through the mutual cooperation of the ingredients through different action mechanisms.

Further preferably, the mouthwash consists of the following raw materials in parts by weight: 6 parts of sorbitol, 1.0 part of glycerol, 2.3 parts of PEG-40 hydrogenated castor oil, (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 0.105 part of mint essence, 0.01 part of clove oil, 0.05 part of paeonol, 0.14 part of grape essence, 0.5 part of potassium sorbate, 3 parts of xylitol, 1.2 parts of rhaponticum uniflorum salt, 0.02 part of citric acid, 0.4 part of wild chrysanthemum flower extract, 0.3 part of liquorice extract, 0.3 part of green tea extract, 0.3 part of mint extract, 1.0 part of thickener, 0.08 part of anti-inflammatory and bactericidal component and 84 parts of water. Through a plurality of tests, the inventor finds that the obtained mouth wash has the optimal performance under the condition of the content of the components.

Preferably, the viscosity of the mouthwash of the invention is less than 280mpa.s at a rheometer speed of 7 r/min.

In the present invention, preferably, the rhaponticum uniflorum salt is a seawater salt produced from Tianjin rhaponticum uniflorum. The refined salt has high bactericidal activity, contains multiple minerals beneficial to human body, has antibacterial and bactericidal effects, and can clean teeth, inhibit bacteria, diminish inflammation, reduce halitosis source, and help solve oral problems.

Preferably, in the propolis powder, the weight percentage of the propolis extract is 90-70%; the weight percentage of the microcrystalline cellulose is 10-30%. Because the propolis extract has strong viscosity, the propolis extract is easy to crush when the temperature is lower than 15 ℃, and is softened when the temperature is higher than 35 ℃, auxiliary materials are required to be added when the propolis extract is crushed to prepare the propolis powder so as to prevent the propolis powder from caking, and the propolis health-care food preparation is convenient to prepare. The microcrystalline cellulose has good effect as an auxiliary material, no additional anticaking agent is needed, and the problem of SiO in the conventional propolis powder product is solved₂Auxiliary material stationPotential safety hazards are brought.

Specifically, the preparation method of the propolis powder comprises the following steps:

s1, fully mixing the pure propolis extract subjected to lead removal with microcrystalline cellulose to obtain a mixture;

s2, circularly crushing the mixture through airflow, wherein the flow rate of the airflow is 8-12m³Min, the exhaust pressure is 1.0 Mpa;

s3, screening, namely screening the crushed mixture by using a screening tool;

s4, placing the sieved mixture into a mixer, and uniformly stirring the mixture to obtain the propolis powder with the fineness of 200-250 meshes. The preparation method of the propolis powder is convenient to operate; especially, the mixture of the propolis extract and the microcrystalline cellulose is crushed by airflow, so that a drying process is avoided, the processing time is shortened, and the production efficiency is improved.

In the invention, the wild chrysanthemum flower extract, the liquorice extract, the green tea extract and the mint extract are all in liquid state and have good compatibility with water. The wild chrysanthemum flower extract, the liquorice extract, the green tea extract and the mint extract can be prepared by adopting the conventional means in the prior art.

The invention also provides a preparation method of the low-viscosity sea salt oral care mouth wash, which comprises the following steps:

adding sorbitol, glycerol and PEG-40 hydrogenated castor oil into water in a sterile room, uniformly stirring, adding (1R,2S,5R) -N- (4- (cyanomethyl) phenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, mint essence, clove oil, paeonol, grape essence, potassium sorbate, xylitol, rhaponticum uniflorum salt, citric acid, wild chrysanthemum flower extract, liquorice extract, green tea extract and mint extract, fully dissolving and uniformly stirring, finally adding an anti-inflammatory and bactericidal component and a thickening agent, and uniformly stirring to obtain the low-viscosity sea salt oral care mouthwash.

Compared with the prior art, the invention has the beneficial effects that:

1. the low-viscosity sea salt oral care mouth wash provided by the invention achieves the purposes of resisting bacteria, diminishing inflammation, clearing heat, purging fire and detoxifying in oral cavity through the selection and content setting of the components and the mutual cooperation of the components through different action mechanisms.

2. The oral care mouth wash developed by the invention is a low-viscosity solution, has high suspension force and high fluidity through formula component selection and content optimization. The formula does not contain alcohol, and solid substances which are difficult to dissolve in water can be suspended in the mouthwash, so that the application range and the use experience of the mouthwash are enlarged.

3. A certain amount of hyaluronic acid is added into the mouthwash to be compounded and adjusted with the xanthan gum and the hydroxyethyl cellulose, so that the mouthwash can meet the requirement of lower viscosity and can suspend the propolis powder, and the propolis powder can suspend uniformly without sedimentation.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments, but the scope of the present invention is not limited to the embodiments.

The starting materials used in the following examples are all commercially available.